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Bernd Groner

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
22
Hynes, Nancy
21
Wels, Winfried
17
Gouilleux, Fabrice
12
Moriggl, Richard
10
Stöcklin, E
9
Schmidt, Manfred
8
Berchtold, S
7
Borghouts, Corina
7
Kunz, Christian
6
Altenschmidt, U
6
Azemar, Marc
6
Friis, Robert
6
Schnierle, Barbara
6
Wissler, Manuela
5
Saurer, Susanne

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Publications

TOP 3
Groner Bernd; Vafaizadeh Vida; Brill Boris; Klemmt Petra
Mammary epithelial and breast cancer stem cells.
Humar Matjaz; Maurer Martina; Azemar Marc; Groner Bernd
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis.
Groner Bernd; Lucks Peter; Borghouts Corina
The function of Stat3 in tumor cells and their microenvironment.

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All Publications

2009: Groner Bernd; Vafaizadeh Vida; Brill Boris; Klemmt Petra
Mammary epithelial and breast cancer stem cells.
European journal of cancer (Oxford, England : 1990) 2009;45 Suppl 1():186-93.
2009: Humar Matjaz; Maurer Martina; Azemar Marc; Groner Bernd
DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis.
Journal of cancer research and clinical oncology 2009;135(4):567-80.
2008: Groner Bernd; Lucks Peter; Borghouts Corina
The function of Stat3 in tumor cells and their microenvironment.
Seminars in cell & developmental biology 2008;19(4):341-50.
2008: Borghouts Corina; Kunz Christian; Groner Bernd
Peptide aptamer libraries.
Combinatorial chemistry & high throughput screening 2008;11(2):135-45.
2008: Borghouts Corina; Kunz Christian; Delis Natalia; Groner Bernd
Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition.
Molecular cancer research : MCR 2008;6(2):267-81.
2008: Brill B; Boecher N; Groner B; Shemanko C S
A sparing procedure to clear the mouse mammary fat pad of epithelial components for transplantation analysis.
Laboratory animals 2008;42(1):104-10.
2007: Eilon Tali; Groner Bernd; Barash Itamar
Tumors caused by overexpression and forced activation of Stat5 in mammary epithelial cells of transgenic mice are parity-dependent and developed in aged, postestropausal females.
International journal of cancer. Journal international du cancer 2007;121(9):1892-902.
2007: Desrivières Sylvane; Kuhn Karsten; Müller Jörg; Gläser Melanie; Laria Nahomi Castro-Palomino; Korder Jutta; Sonnentag Michael; Neumann Thomas; Schwarz Josef; Schäfer Jürgen; Hamon Christian; Groner Bernd; Prinz Thorsten
Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation.
Proteomics 2007;7(12):2019-37.
2007: Groner Bernd
Introduction: the rationale for the development of targeted drugs in cancer therapy.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;172():1-3.
2006: Kunz Christian; Borghouts Corina; Buerger Claudia; Groner Bernd
Peptide aptamers with binding specificity for the intracellular domain of the ErbB2 receptor interfere with AKT signaling and sensitize breast cancer cells to Taxol.
Molecular cancer research : MCR 2006;4(12):983-98.
2006: Jankiewicz Marcin; Groner Bernd; Desrivières Sylvane
Mammalian target of rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional differentiation through Id2.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2369-81.
2006: Iavnilovitch Elena; Eilon Tali; Groner Bernd; Barash Itamar
Expression of a carboxy terminally truncated Stat5 with no transactivation domain in the mammary glands of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion, and induces apoptosis upon involution.
Molecular reproduction and development 2006;73(7):841-9.
2006: Desrivières Sylvane; Kunz Christian; Barash Itamar; Vafaizadeh Vida; Borghouts Corina; Groner Bernd
The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition.
Journal of mammary gland biology and neoplasia 2006;11(1):75-87.
2005: Wittig Ilka; Groner Bernd
Signal transducer and activator of transcription 5 (STAT5), a crucial regulator of immune and cancer cells.
Current drug targets. Immune, endocrine and metabolic disorders 2005;5(4):449-63.
2005: Borghouts Corina; Kunz Christian; Groner Bernd
Current strategies for the development of peptide-based anti-cancer therapeutics.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(11):713-26.
2005: Borghouts Corina; Kunz Christian; Groner Bernd
Peptide aptamers: recent developments for cancer therapy.
Expert opinion on biological therapy 2005;5(6):783-97.
2005: Bähr Corinna; Groner Bernd
The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function.
Growth factors (Chur, Switzerland) 2005;23(1):1-14.
2004: Iavnilovitch Elena; Cardiff Robert D; Groner Bernd; Barash Itamar
Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice.
International journal of cancer. Journal international du cancer 2004;112(4):607-19.
2004: Groner Bernd; Hartmann Cord; Wels Winfried
Therapeutic antibodies.
Current molecular medicine 2004;4(5):539-47.
2004: Bähr Corinna; Groner Bernd
The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2004;14(4):287-95.
2004: Nagel-Wolfrum Kerstin; Buerger Claudia; Wittig Ilka; Butz Karin; Hoppe-Seyler Felix; Groner Bernd
The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells.
Molecular cancer research : MCR 2004;2(3):170-82.
2004: Gewinner Christina; Hart Gerald; Zachara Natasha; Cole Robert; Beisenherz-Huss Christian; Groner Bernd
The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5.
The Journal of biological chemistry 2004;279(5):3563-72.
2003: Azemar Marc; Djahansouzi Sirus; Jäger Elke; Solbach Christine; Schmidt Mathias; Maurer Alexander B; Mross Klaus; Unger Clemens; von Minckwitz Gunter; Dall Peter; Groner Bernd; Wels Winfried S
Regression of cutaneous tumor lesions in patients intratumorally injected with a recombinant single-chain antibody-toxin targeted to ErbB2/HER2.
Breast cancer research and treatment 2003;82(3):155-64.
2003: Buerger Claudia; Groner Bernd
Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling.
Journal of cancer research and clinical oncology 2003;129(12):669-75.
2003: Desrivières Sylvane; Prinz Thorsten; Castro-Palomino Laria Nahomi; Meyer Markus; Boehm Gitte; Bauer Ute; Schäfer Jürgen; Neumann Thomas; Shemanko Carrie; Groner Bernd
Comparative proteomic analysis of proliferating and functionally differentiated mammary epithelial cells.
Molecular & cellular proteomics : MCP 2003;2(10):1039-54.
2003: Buerger Claudia; Nagel-Wolfrum Kerstin; Kunz Christian; Wittig Ilka; Butz Karin; Hoppe-Seyler Felix; Groner Bernd
Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.
The Journal of biological chemistry 2003;278(39):37610-21.
2003: Krämer Oliver H; Zhu Ping; Ostendorff Heather P; Golebiewski Martin; Tiefenbach Jens; Peters Marvin A; Brill Boris; Groner Bernd; Bach Ingolf; Heinzel Thorsten; Göttlicher Martin
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2.
The EMBO journal 2003;22(13):3411-20.
2003: Belaus Andrea; Merkle Christian; Fritsche Michael; Groner Bernd
Crosstalk between the extracellular domain of the ErbB2 receptor and IGF-1 receptor signaling.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):105-15.
2002: Iavnilovitch Elena; Groner Bernd; Barash Itamar
Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis.
Molecular cancer research : MCR 2002;1(1):32-47.
2002: Groner Bernd
Transcription factor regulation in mammary epithelial cells.
Domestic animal endocrinology 2002;23(1-2):25-32.
2002: Maurer Alexander B; Wichmann Christian; Gross Alexandra; Kunkel Hana; Heinzel Thorsten; Ruthardt Martin; Groner Bernd; Grez Manuel
The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex.
Blood 2002;99(8):2647-52.
2002: Groner B; Shemanko C
Cooperation of nuclear transcription factors regulated by steroid and peptide hormones.
Ernst Schering Research Foundation workshop 2002;(40):213-31.
2001: Beisenherz-Huss C; Mundt M; Herrala A; Vihko P; Schubert A; Groner B
Specific DNA binding and transactivation potential of recombinant, purified Stat5.
Molecular and cellular endocrinology 2001;183(1-2):101-12.
2001: Uherek C; Groner B; Wels W
Chimeric antigen receptors for the retargeting of cytotoxic effector cells.
Journal of hematotherapy & stem cell research 2001;10(4):523-34.
2001: Schmidt M; McWatters A; White R A; Groner B; Wels W; Fan Z; Bast R C
Synergistic interaction between an anti-p185HER-2 pseudomonas exotoxin fusion protein [scFv(FRP5)-ETA] and ionizing radiation for inhibiting growth of ovarian cancer cells that overexpress HER-2.
Gynecologic oncology 2001;80(2):145-55.
2000: Groner B; Fritsche M; Stöcklin E; Berchtold S; Merkle C; Moriggl R; Pfitzner E
Regulation of the trans-activation potential of STAT5 through its DNA-binding activity and interactions with heterologous transcription factors.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10 Suppl B():S15-20.
2000: Azemar M; Schmidt M; Arlt F; Kennel P; Brandt B; Papadimitriou A; Groner B; Wels W
Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and cause rapid tumor regression in vivo.
International journal of cancer. Journal international du cancer 2000;86(2):269-75.
2000: Groner B; Hennighausen L
Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium.
Breast cancer research : BCR 2000;2(3):149-53.
1999: Gerstmayer B; Groner B; Wels W; Schnierle B S
Stable expression of the ecotropic retrovirus receptor in amphotropic packaging cells facilitates the transfer of recombinant vectors and enhances the yield of retroviral particles.
Journal of virological methods 1999;81(1-2):71-5.
1999: Höhne M; Thaler S; Dudda J C; Groner B; Schnierle B S
Truncation of the human immunodeficiency virus-type-2 envelope glycoprotein allows efficient pseudotyping of murine leukemia virus retroviral vector particles.
Virology 1999;261(1):70-8.
1999: Gingras S; Simard J; Groner B; Pfitzner E
p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6.
Nucleic acids research 1999;27(13):2722-9.
1999: Stoecklin E; Wissler M; Schaetzle D; Pfitzner E; Groner B
Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):195-204.
1999: Schmidt M; Maurer-Gebhard M; Groner B; Köhler G; Brochmann-Santos G; Wels W
Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors.
Oncogene 1999;18(9):1711-21.
1999: Maurer-Gebhard M; Schmidt M; Azemar M; Stöcklin E; Wels W; Groner B
A novel animal model for the evaluation of the efficacy of drugs directed against the ErbB2 receptor on metastasis formation.
Hybridoma 1999;18(1):69-75.
1999: Gingras S; Moriggl R; Groner B; Simard J
Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.
Molecular endocrinology (Baltimore, Md.) 1999;13(1):66-81.
1998: Merkle C; Fritsche M; Mundt M; Jähne R; Groner B
Transcriptional regulation and induction of apoptosis: implications for the use of monomeric p53 variants in gene therapy.
Gene therapy 1998;5(12):1631-41.
1998: Lischke A; Moriggl R; Brändlein S; Berchtold S; Kammer W; Sebald W; Groner B; Liu X; Hennighausen L; Friedrich K
The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain.
The Journal of biological chemistry 1998;273(47):31222-9.
1998: Pfitzner E; Jähne R; Wissler M; Stoecklin E; Groner B
p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response.
Molecular endocrinology (Baltimore, Md.) 1998;12(10):1582-93.
1998: Fritsche M; Mundt M; Merkle C; Jähne R; Groner B
p53 suppresses cytokine induced, Stat5 mediated activation of transcription.
Molecular and cellular endocrinology 1998;143(1-2):143-54.
1998: Maurer-Gebhard M; Schmidt M; Azemar M; Altenschmidt U; Stöcklin E; Wels W; Groner B
Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells.
Cancer research 1998;58(12):2661-6.
1998: Piekorz R P; Rinke R; Gouilleux F; Neumann B; Groner B; Hocke G M
Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells.
Biochimica et biophysica acta 1998;1402(3):313-23.
1998: Berchtold S; Volarevic S; Moriggl R; Mercep M; Groner B
Dominant negative variants of the SHP-2 tyrosine phosphatase inhibit prolactin activation of Jak2 (janus kinase 2) and induction of Stat5 (signal transducer and activator of transcription 5)-dependent transcription.
Molecular endocrinology (Baltimore, Md.) 1998;12(4):556-67.
1998: Moriggl R; Kristofic C; Kinzel B; Volarevic S; Groner B; Brinkmann V
Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3385-92.
1998: Spyridonidis A; Schmidt M; Bernhardt W; Papadimitriou A; Azemar M; Wels W; Groner B; Henschler R
Purging of mammary carcinoma cells during ex vivo culture of CD34+ hematopoietic progenitor cells with recombinant immunotoxins.
Blood 1998;91(5):1820-7.
1998: Moriggl R; Erhardt I; Kammer W; Berchtold S; Schnarr B; Lischke A; Groner B; Friedrich K
Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.
European journal of biochemistry / FEBS 1998;251(1-2):25-35.
1998: Altiok S; Groner B
Regulation of gene expression in mammary epithelial cells by cellular confluence and sequence-specific DNA binding factors.
Biochemical Society symposium 1998;63():115-31.
1997: Altenschmidt U; Klundt E; Groner B
Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5509-15.
1997: Berchtold S; Moriggl R; Gouilleux F; Silvennoinen O; Beisenherz C; Pfitzner E; Wissler M; Stöcklin E; Groner B
Cytokine receptor-independent, constitutively active variants of STAT5.
The Journal of biological chemistry 1997;272(48):30237-43.
1997: Stoecklin E; Wissler M; Moriggl R; Groner B
Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription.
Molecular and cellular biology 1997;17(11):6708-16.
1997: Wick B; Groner B
Evaluation of cell surface antigens as potential targets for recombinant tumor toxins.
Cancer letters 1997;118(2):161-72.
1997: Altenschmidt U; Schmidt M; Groner B; Wels W
Targeted therapy of schwannoma cells in immunocompetent rats with an erbB2-specific antibody-toxin.
International journal of cancer. Journal international du cancer 1997;73(1):117-24.
1997: Schnierle B S; Stitz J; Bosch V; Nocken F; Merget-Millitzer H; Engelstädter M; Kurth R; Groner B; Cichutek K
Pseudotyping of murine leukemia virus with the envelope glycoproteins of HIV generates a retroviral vector with specificity of infection for CD4-expressing cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8640-5.
1997: Mundt M; Hupp T; Fritsche M; Merkle C; Hansen S; Lane D; Groner B
Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential.
Oncogene 1997;15(2):237-44.
1997: Moriggl R; Berchtold S; Friedrich K; Standke G J; Kammer W; Heim M; Wissler M; Stöcklin E; Gouilleux F; Groner B
Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells.
Molecular and cellular biology 1997;17(7):3663-78.
1997: Hansen J A; Hansen L H; Wang X; Kopchick J J; Gouilleux F; Groner B; Nielsen J H; Møldrup A; Galsgaard E D; Billestrup N
The role of GH receptor tyrosine phosphorylation in Stat5 activation.
Journal of molecular endocrinology 1997;18(3):213-21.
1997: Altenschmidt U; Moritz D; Groner B
Specific cytotoxic T lymphocytes in gene therapy.
Journal of molecular medicine (Berlin, Germany) 1997;75(4):259-66.
1997: Groner B; Wick B; Jeschke M; Fiebig H H; Dengler W; Runau T; Mihatsch M; Kahl R; Schmidt M; Wels W; Stöcklin E
Intra-tumoral application of a heregulin-exotoxin-a fusion protein causes rapid tumor regression without adverse systemic or local effects.
International journal of cancer. Journal international du cancer 1997;70(6):682-7.
1997: Altenschmidt U; Kahl R; Klundt E; Stöcklin E; Mihatsch M; Weindel K; Groner B
Schwannoma cells induce a tumor-cell-specific cytotoxic-T-cell response upon transplantation into syngeneic rats but escape elimination through the secretion of immunosuppressive factors.
International journal of cancer. Journal international du cancer 1997;70(5):542-50.
1996: Schnierle B S; Groner B
Retroviral targeted delivery.
Gene therapy 1996;3(12):1069-73.
1996: Wartmann M; Cella N; Hofer P; Groner B; Liu X; Hennighausen L; Hynes N E
Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activity.
The Journal of biological chemistry 1996;271(50):31863-8.
1996: Hekele A; Dall P; Moritz D; Wels W; Groner B; Herrlich P; Ponta H
Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera.
International journal of cancer. Journal international du cancer 1996;68(2):232-8.
1996: Stöcklin E; Wissler M; Gouilleux F; Groner B
Functional interactions between Stat5 and the glucocorticoid receptor.
Nature 1996;383(6602):726-8.
1996: Wehinger J; Gouilleux F; Groner B; Finke J; Mertelsmann R; Weber-Nordt R M
IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes.
FEBS letters 1996;394(3):365-70.
1996: Moriggl R; Gouilleux-Gruart V; Jähne R; Berchtold S; Gartmann C; Liu X; Hennighausen L; Sotiropoulos A; Groner B; Gouilleux F
Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.
Molecular and cellular biology 1996;16(10):5691-700.
1996: Kammer W; Lischke A; Moriggl R; Groner B; Ziemiecki A; Gurniak C B; Berg L J; Friedrich K
Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling.
The Journal of biological chemistry 1996;271(39):23634-7.
1996: Altenschmidt U; Kahl R; Moritz D; Schnierle B S; Gerstmayer B; Wels W; Groner B
Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):1001-8.
1996: Gobert S; Chretien S; Gouilleux F; Muller O; Pallard C; Dusanter-Fourt I; Groner B; Lacombe C; Gisselbrecht S; Mayeux P
Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.
The EMBO journal 1996;15(10):2434-41.
1996: Schnierle B S; Moritz D; Jeschke M; Groner B
Expression of chimeric envelope proteins in helper cell lines and integration into Moloney murine leukemia virus particles.
Gene therapy 1996;3(4):334-42.
1996: Gouilleux-Gruart V; Gouilleux F; Desaint C; Claisse J F; Capiod J C; Delobel J; Weber-Nordt R; Dusanter-Fourt I; Dreyfus F; Groner B; Prin L
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.
Blood 1996;87(5):1692-7.
1996: Schmidt M; Hynes N E; Groner B; Wels W
A bivalent single-chain antibody-toxin specific for ErbB-2 and the EGF receptor.
International journal of cancer. Journal international du cancer 1996;65(4):538-46.
1996: Wels W; Groner B; Hynes N E
Intervention in receptor tyrosine kinase-mediated pathways: recombinant antibody fusion proteins targeted to ErbB2.
Current topics in microbiology and immunology 1996;213 ( Pt 3)():113-28.
1995: Gouilleux F; Moritz D; Humar M; Moriggl R; Berchtold S; Groner B
Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor.
Endocrinology 1995;136(12):5700-8.
1995: Moritz D; Groner B
A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity.
Gene therapy 1995;2(8):539-46.
1995: Pallard C; Gouilleux F; Charon M; Groner B; Gisselbrecht S; Dusanter-Fourt I
Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells.
The Journal of biological chemistry 1995;270(27):15942-5.
1995: Hynes N E; Groner B
A target for tumour-directed therapy.
Nature medicine 1995;1(7):631.
1995: Pallard C; Gouilleux F; Bénit L; Cocault L; Souyri M; Levy D; Groner B; Gisselbrecht S; Dusanter-Fourt I
Thrombopoietin activates a STAT5-like factor in hematopoietic cells.
The EMBO journal 1995;14(12):2847-56.
1995: Wels W; Moritz D; Schmidt M; Jeschke M; Hynes N E; Groner B
Biotechnological and gene therapeutic strategies in cancer treatment.
Gene 1995;159(1):73-80.
1995: Gouilleux F; Pallard C; Dusanter-Fourt I; Wakao H; Haldosen L A; Norstedt G; Levy D; Groner B
Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.
The EMBO journal 1995;14(9):2005-13.
1995: Wood T J; Sliva D; Lobie P E; Pircher T J; Gouilleux F; Wakao H; Gustafsson J A; Groner B; Norstedt G; Haldosén L A
Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5.
The Journal of biological chemistry 1995;270(16):9448-53.
1995: Jeschke M; Wels W; Dengler W; Imber R; Stöcklin E; Groner B
Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins.
International journal of cancer. Journal international du cancer 1995;60(5):730-9.
1995: Wakao H; Gouilleux F; Groner B
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.
The EMBO journal 1995;14(4):854-5.
1995: Wels W; Beerli R; Hellmann P; Schmidt M; Marte B M; Kornilova E S; Hekele A; Mendelsohn J; Groner B; Hynes N E
EGF receptor and p185erbB-2-specific single-chain antibody toxins differ in their cell-killing activity on tumor cells expressing both receptor proteins.
International journal of cancer. Journal international du cancer 1995;60(1):137-44.
1995: Marte B M; Jeschke M; Graus-Porta D; Taverna D; Hofer P; Groner B; Yarden Y; Hynes N E
Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells.
Molecular endocrinology (Baltimore, Md.) 1995;9(1):14-23.
1994: Messerle K; Schlegel J; Hynes N E; Groner B
NIH/3T3 cells transformed with the activated erbB-2 oncogene can be phenotypically reverted by a kinase deficient, dominant negative erbB-2 variant.
Molecular and cellular endocrinology 1994;105(1):1-10.
1994: Altiok S; Groner B
beta-Casein mRNA sequesters a single-stranded nucleic acid-binding protein which negatively regulates the beta-casein gene promoter.
Molecular and cellular biology 1994;14(9):6004-12.
1994: Gouilleux F; Wakao H; Mundt M; Groner B
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
The EMBO journal 1994;13(18):4361-9.
1994: Moritz D; Wels W; Mattern J; Groner B
Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4318-22.
1994: Wakao H; Gouilleux F; Groner B
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.
The EMBO journal 1994;13(9):2182-91.
1994: Groner B; Altiok S; Meier V
Hormonal regulation of transcription factor activity in mammary epithelial cells.
Molecular and cellular endocrinology 1994;100(1-2):109-14.
1994: Standke G J; Meier V S; Groner B
Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential.
Molecular endocrinology (Baltimore, Md.) 1994;8(4):469-77.
1994: Meier V S; Groner B
The nuclear factor YY1 participates in repression of the beta-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction.
Molecular and cellular biology 1994;14(1):128-37.
1993: Happ B; Groner B
The activated mammary gland specific nuclear factor (MGF) enhances in vitro transcription of the beta-casein gene promoter.
The Journal of steroid biochemistry and molecular biology 1993;47(1-6):21-30.
1993: Altiok S; Groner B
Interaction of two sequence-specific single-stranded DNA-binding proteins with an essential region of the beta-casein gene promoter is regulated by lactogenic hormones.
Molecular and cellular biology 1993;13(12):7303-10.
1993: Stöcklin E; Botteri F; Groner B
An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice.
The Journal of cell biology 1993;122(1):199-208.
1993: Happ B; Hynes N E; Groner B
Ha-ras and v-raf oncogenes, but not int-2 and c-myc, interfere with the lactogenic hormone dependent activation of the mammary gland specific transcription factor.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(1):9-15.
1992: Schmitt-Ney M; Happ B; Hofer P; Hynes N E; Groner B
Mammary gland-specific nuclear factor activity is positively regulated by lactogenic hormones and negatively by milk stasis.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):1988-97.
1992: Wels W; Harwerth I M; Mueller M; Groner B; Hynes N E
Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor.
Cancer research 1992;52(22):6310-7.
1992: Wels W; Harwerth I M; Zwickl M; Hardman N; Groner B; Hynes N E
Construction, bacterial expression and characterization of a bifunctional single-chain antibody-phosphatase fusion protein targeted to the human erbB-2 receptor.
Bio/technology (Nature Publishing Company) 1992;10(10):1128-32.
1992: Wels W; Harwerth I M; Hynes N E; Groner B
Diminution of antibodies directed against tumor cell surface epitopes: a single chain Fv fusion molecule specifically recognizes the extracellular domain of the c-erbB-2 receptor.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):1-7.
1992: Wakao H; Schmitt-Ney M; Groner B
Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa.
The Journal of biological chemistry 1992;267(23):16365-70.
1992: Groner B
Oncogene expression in mammary epithelial cells.
Journal of cellular biochemistry 1992;49(2):128-36.
1992: Schmitt-Ney M; Happ B; Ball R K; Groner B
Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3130-4.
1992: Buck K; Vanek M; Groner B; Ball R K
Multiple forms of prolactin receptor messenger ribonucleic acid are specifically expressed and regulated in murine tissues and the mammary cell line HC11.
Endocrinology 1992;130(3):1108-14.
1992: Hoeck W; Hofer P; Groner B
Overexpression of the glucocorticoid receptor represses transcription from hormone responsive and non-responsive promoters.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):283-9.
1991: Doppler W; Villunger A; Jennewein P; Brduscha K; Groner B; Ball R K
Lactogenic hormone and cell type-specific control of the whey acidic protein gene promoter in transfected mouse cells.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1624-32.
1991: Schmitt-Ney M; Doppler W; Ball R K; Groner B
Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor.
Molecular and cellular biology 1991;11(7):3745-55.
1991: Taverna D; Groner B; Hynes N E
Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(3):145-54.
1990: Groner B
Transcriptional control and cellular transformation.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1990;1(5):321-5.
1990: Hynes N E; Taverna D; Harwerth I M; Ciardiello F; Salomon D S; Yamamoto T; Groner B
Epidermal growth factor receptor, but not c-erbB-2, activation prevents lactogenic hormone induction of the beta-casein gene in mouse mammary epithelial cells.
Molecular and cellular biology 1990;10(8):4027-34.
1990: Richner J; Gerber H A; Locher G W; Goldhirsch A; Gelber R D; Gullick W J; Berger M S; Groner B; Hynes N E
c-erbB-2 protein expression in node negative breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1990;1(4):263-8.
1990: Schoenenberger C A; Zuk A; Groner B; Jones W; Andres A C
Induction of the endogenous whey acidic protein (Wap) gene and a Wap-myc hybrid gene in primary murine mammary organoids.
Developmental biology 1990;139(2):327-37.
1990: Doppler W; Höck W; Hofer P; Groner B; Ball R K
Prolactin and glucocorticoid hormones control transcription of the beta-casein gene by kinetically distinct mechanisms.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):912-9.
1990: Groner B; Hynes N E
Mutations in human breast cancer cells: dominantly-acting oncogenes and tumor suppressor genes suggest strategies for targeted interference.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1990;5():40-6.
1989: Bütler M T; Ziemiecki A; Groner B; Friis R R
Characterization of a membrane-associated phosphotyrosyl protein phosphatase from the A431 human epidermoid carcinoma cell line.
European journal of biochemistry / FEBS 1989;185(2):475-83.
1989: Jaggi R; Höck W; Ziemiecki A; Klemenz R; Friis R; Groner B
Oncogene mediated repression of glucocorticoid hormone response elements and glucocorticoid receptor levels.
Cancer research 1989;49(8 Suppl):2266s-2274s.
1989: Reichmann E; Ball R; Groner B; Friis R R
New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally.
The Journal of cell biology 1989;108(3):1127-38.
1989: Hynes N E; Gerber H A; Saurer S; Groner B
Overexpression of the c-erbB-2 protein in human breast tumor cell lines.
Journal of cellular biochemistry 1989;39(2):167-73.
1989: Doppler W; Groner B; Ball R K
Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):104-8.
1989: Höck W; Martin F; Jaggi R; Groner B
Regulation of glucocorticoid receptor activity.
Journal of steroid biochemistry 1989;34(1-6):71-8.
1988: Andres A C; van der Valk M A; Schönenberger C A; Flückiger F; LeMeur M; Gerlinger P; Groner B
Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.
Genes & development 1988;2(11):1486-95.
1988: Ball R K; Friis R R; Schoenenberger C A; Doppler W; Groner B
Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line.
The EMBO journal 1988;7(7):2089-95.
1988: Jaggi R; Friis R; Groner B
Oncogenes modulate cellular gene expression and repress glucocorticoid regulated gene transcription.
Journal of steroid biochemistry 1988;29(5):457-63.
1988: Redmond S M; Reichmann E; Müller R G; Friis R R; Groner B; Hynes N E
The transformation of primary and established mouse mammary epithelial cells by p21-ras is concentration dependent.
Oncogene 1988;2(3):259-65.
1988: Berger M S; Locher G W; Saurer S; Gullick W J; Waterfield M D; Groner B; Hynes N E
Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.
Cancer research 1988;48(5):1238-43.
1988: Ball R K; Ziemiecki A; Schönenberger C A; Reichmann E; Redmond S M; Groner B
v-myc alters the response of a cloned mouse mammary epithelial cell line to lactogenic hormones.
Molecular endocrinology (Baltimore, Md.) 1988;2(2):133-42.
1988: Kozma S C; Redmond S M; Fu X C; Saurer S M; Groner B; Hynes N E
Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences.
The EMBO journal 1988;7(1):147-54.
1988: Schoenenberger C A; Andres A C; Groner B; van der Valk M; LeMeur M; Gerlinger P
Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.
The EMBO journal 1988;7(1):169-75.
1988: Groner B; Hynes N E; Kozma S; Redmond S; Saurer S; Schmitt-Ney M; Ball R; Reichmann E; Shöenberger C; Andres A C
Identification of oncogenes in breast tumors and their effects on growth and differentiation.
Cancer treatment and research 1988;40():67-92.
1987: Kozma S C; Bogaard M E; Buser K; Saurer S M; Bos J L; Groner B; Hynes N E
The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.
Nucleic acids research 1987;15(15):5963-71.
1987: Andres A C; Schönenberger C A; Groner B; Hennighausen L; LeMeur M; Gerlinger P
Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(5):1299-303.
1986: Jaggi R; Salmons B; Muellener D; Groner B
The v-mos and H-ras oncogene expression represses glucocorticoid hormone-dependent transcription from the mouse mammary tumor virus LTR.
The EMBO journal 1986;5(10):2609-16.
1986: Salmons B; Groner B; Friis R; Muellener D; Jaggi R
Expression of anti-sense mRNA in H-ras transfected NIH/3T3 cells does not suppress the transformed phenotype.
Gene 1986;45(2):215-20.
1985: Hynes N E; Jaggi R; Kozma S C; Ball R; Muellener D; Wetherall N T; Davis B W; Groner B
New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line.
Molecular and cellular biology 1985;5(1):268-72.

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