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Douglas Grosenbach

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Publications

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Marina Zaitseva; Stephanie Cruz; Claudia G Diaz; Douglas W Grosenbach; Robert A Jordan; Lisa R King; Jody Manischewitz; John Scott; Elisabeth Shotwell; Hana Golding
Effects of Postchallenge Administration of ST-246 on Dissemination of IHD-J-Luc Vaccinia Virus in Normal Mice and in Immune-Deficient Mice Reconstituted with T Cells.
Chelsea M Byrd; Kara B Cardwell; Dongcheng Dai; Kathleen P Fuller; Douglas W Grosenbach; Chris Harver; Dennis E Hruby; Kevin F Jones; Janet M Leeds; Candace Lovejoy; Jessica Page; Christine Schneider; Eric Stavale; Melialani A Stone; Shanthakumar Tyavanagimatt; Kristin A Wineinger; Guang Yang; Aklile Berhanu; Robert Jordan
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Janet M Leeds; Jean-Francois Marier; Mohamad-Samer Mouksassi; Shanthakumar R Tyavanagimatt; Nastya Kassir; Yali Chen; Jarasvech Chinsangaram; Frederique Fenneteau; Annie E Frimm; Nathalie H Gosselin; Douglas W Grosenbach; Kady M Honeychurch; Dennis E Hruby; Robert Jordan
Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.

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All Publications

2013: Marina Zaitseva; Stephanie Cruz; Claudia G Diaz; Douglas W Grosenbach; Robert A Jordan; Lisa R King; Jody Manischewitz; John Scott; Elisabeth Shotwell; Hana Golding
Effects of Postchallenge Administration of ST-246 on Dissemination of IHD-J-Luc Vaccinia Virus in Normal Mice and in Immune-Deficient Mice Reconstituted with T Cells.
Journal of virology 2013;87(10):5564-76.
2013: Chelsea M Byrd; Kara B Cardwell; Dongcheng Dai; Kathleen P Fuller; Douglas W Grosenbach; Chris Harver; Dennis E Hruby; Kevin F Jones; Janet M Leeds; Candace Lovejoy; Jessica Page; Christine Schneider; Eric Stavale; Melialani A Stone; Shanthakumar Tyavanagimatt; Kristin A Wineinger; Guang Yang; Aklile Berhanu; Robert Jordan
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Antimicrobial agents and chemotherapy 2013;57(4):1902-12.
2013: Janet M Leeds; Jean-Francois Marier; Mohamad-Samer Mouksassi; Shanthakumar R Tyavanagimatt; Nastya Kassir; Yali Chen; Jarasvech Chinsangaram; Frederique Fenneteau; Annie E Frimm; Nathalie H Gosselin; Douglas W Grosenbach; Kady M Honeychurch; Dennis E Hruby; Robert Jordan
Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.
Antimicrobial agents and chemotherapy 2013;57(3):1136-43.
2013: Chelsea M Byrd; Kara B Cardwell; Dongcheng Dai; Douglas W Grosenbach; Chris Harver; Dennis E Hruby; Kevin F Jones; Jessica M Page; Pietro Scaturro; Christine Schneider; Eric Stavale; Melialani A Stone; Shanthakumar Tyavanagimatt; Kristin A Wineinger; Ralf Bartenschlager; Aklile Berhanu; Robert Jordan
A novel inhibitor of dengue virus replication that targets the capsid protein.
Antimicrobial agents and chemotherapy 2013;57(1):15-25.
2010: Aklile Berhanu; David S King; Stacie Mosier; Robert Jordan; Kevin F Jones; Dennis E Hruby; Douglas W Grosenbach
Impact of ST-246® on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice.
Vaccine 2010;29(2):289-303.
2010: Douglas W Grosenbach; Aklile Berhanu; David S King; Stacie Mosier; Kevin F Jones; Robert A Jordan; Tove' C Bolken; Dennis E Hruby
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):838-43.
2009: Aklile Berhanu; David S King; Stacie Mosier; Robert Jordan; Kevin F Jones; Dennis E Hruby; Douglas W Grosenbach
ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.
Antimicrobial agents and chemotherapy 2009;53(12):4999-5009.
2008: Aklile Berhanu; Rebecca L Wilson; Dana L Kirkwood-Watts; David S King; Travis K Warren; Susan A Lund; Lindsay L Brown; Alex K Krupkin; Erin Vandermay; Will Weimers; Kady M Honeychurch; Douglas W Grosenbach; Kevin F Jones; Dennis E Hruby
Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge.
Journal of virology 2008;82(7):3517-29.
2008: Douglas W Grosenbach; Robert Jordan; David S King; Aklile Berhanu; Travis K Warren; Dana L Kirkwood-Watts; Shanthakumar Tyavanagimatt; Ying Tan; Rebecca L Wilson; Kevin F Jones; Dennis E Hruby
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination.
Vaccine 2008;26(7):933-46.
2007: Mary Litzinger; Romaine Fernando; Tyler J Curiel; Douglas W Grosenbach; Jeffrey Schlom; Claudia Palena
IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity.
Blood 2007;110(9):3192-201.
2007: Philip M Arlen; Lisa Skarupa; Mary Pazdur; Mahesh Seetharam; Kwong-Yok Tsang; Douglas W Grosenbach; Jarett Feldman; Diane J Poole; Mary Litzinger; Seth M Steinberg; Elizabeth Jones; Clara Chen; Jennifer Marte; Howard L Parnes; John Wright; William Dahut; Jeffrey Schlom; James L Gulley
Clinical safety of a viral vector based prostate cancer vaccine strategy.
The Journal of urology 2007;178(4 Pt 1):1515-20.
2006: Philip M Arlen; James L Gulley; Catherine Parker; Lisa Skarupa; Mary Pazdur; Dennis Panicali; Patricia Beetham; Kwong-Yok Tsang; Douglas W Grosenbach; Jarett Feldman; Seth M Steinberg; Elizabeth Jones; Clara Chen; Jennifer Marte; Jeffrey Schlom; William Dahut
A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(4):1260-9.
2006: Charlie T Garnett; John W Greiner; Kwong-Yok Tsang; Chie Kudo-Saito; Douglas W Grosenbach; Mala Chakraborty; James L Gulley; Philip M Arlen; Jeffrey Schlom; James W Hodge
TRICOM vector based cancer vaccines.
Current pharmaceutical design 2006;12(3):351-61.
2006: James W Hodge; John W Greiner; Kwong-Yok Tsang; Helen Sabzevari; Chie Kudo-Saito; Douglas W Grosenbach; James L Gulley; Philip M Arlen; John L Marshall; Dennis Panicali; Jeffrey Schlom
Costimulatory molecules as adjuvants for immunotherapy.
Frontiers in bioscience : a journal and virtual library 2006;11():788-803.
2005: Sixun Yang; James W Hodge; Douglas W Grosenbach; Jeffrey Schlom
Vaccines with enhanced costimulation maintain high avidity memory CTL.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3715-23.
2005: Philip M Arlen; James L Gulley; Nushin Todd; Ronald Lieberman; Seth M Steinberg; Steve Morin; Anne Bastian; Jennifer Marte; Kwong-Yok Tsang; Patricia Beetham; Douglas W Grosenbach; Jeffrey Schlom; William Dahut
Antiandrogen, vaccine and combination therapy in patients with nonmetastatic hormone refractory prostate cancer.
The Journal of urology 2005;174(2):539-46.
2005: John L Marshall; James L Gulley; Philip M Arlen; Patricia Beetham; Kwong-Yok Tsang; Rebecca Slack; James W Hodge; Sandra Doren; Douglas W Grosenbach; Jimmy Hwang; Evelyn Fox; Lauretta Odogwu; Susie Park; Dennis Panicali; Jeffrey Schlom
Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(4):720-31.
2004: Jeffrey Schlom; Claudia Palena; John W Greiner; Kwong-Yok Tsang; Douglas W Grosenbach; Helen Sabzevari; James L Gulley; Philip M Arlen; Erik S Kass; James W Hodge
Combinatorial vaccine strategies and the use of molecular arrays to characterize T-cell activation.
Developments in biologicals 2004;116():27-47.
2003: Jeffrey Schlom; Helen Sabzevari; Douglas W Grosenbach; James W Hodge
A triad of costimulatory molecules synergize to amplify T-cell activation in both vector-based and vector-infected dendritic cell vaccines.
Artificial cells, blood substitutes, and immobilization biotechnology 2003;31(2):193-228.
2003: James W Hodge; Douglas W Grosenbach; Wilhelmina M Aarts; Diane J Poole; Jeffrey Schlom
Vaccine therapy of established tumors in the absence of autoimmunity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1837-49.
2003: Douglas W Grosenbach; Jeffrey Schlom; Linda Gritz; Alicia Gómez-Yafal; James W Hodge
A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production.
Cellular immunology 2003;222(1):45-57.
2002: James W Hodge; Douglas W Grosenbach; Jeffrey Schlom
Vector-based delivery of tumor-associated antigens and T-cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity.
Cancer detection and prevention 2002;26(4):275-91.
2001: Douglas W Grosenbach; J C Barrientos; Jeffrey Schlom; James W Hodge
Synergy of vaccine strategies to amplify antigen-specific immune responses and antitumor effects.
Cancer research 2001;61(11):4497-505.
2001: James W Hodge; Douglas W Grosenbach; Ariel Rad; Mariateresa Giuliano; Helen Sabzevari; Jeffrey Schlom
Enhancing the potency of peptide-pulsed antigen presenting cells by vector-driven hyperexpression of a triad of costimulatory molecules.
Vaccine 2001;19(25-26):3552-67.
2000: James W Hodge; Ariel Rad; Douglas W Grosenbach; Helen Sabzevari; Alicia Gómez Yafal; Linda Gritz; Jeffrey Schlom
Enhanced activation of T cells by dendritic cells engineered to hyperexpress a triad of costimulatory molecules.
Journal of the National Cancer Institute 2000;92(15):1228-39.