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Richard Gross

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Michael A Kiebish; Xinping Liu; David J Mancuso; Harold F Sims; Kui Yang; Zhongdan Zhao; W Todd Cade; Rebekah Cerqua; Shaoping Guan; Xianlin Han; Richard W Gross
Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome.
Andreu Viader; Cayce S Workman; Kui Yang; Richard W Gross; Sungsu Kim; Yo Sasaki; Amy Strickland; Jeffrey Milbrandt
Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.
Dipanjan Pan; Nibedita Sanyal; Anne H Schmieder; Angana Senpan; Samuel A Wickline; Xiaoxia Yang; John S Allen; Richard W Gross; Grace Hu; Benjamin Kim; Gregory M Lanza
Antiangiogenic nanotherapy with lipase-labile Sn-2 fumagillin prodrug.

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2013: Michael A Kiebish; Xinping Liu; David J Mancuso; Harold F Sims; Kui Yang; Zhongdan Zhao; W Todd Cade; Rebekah Cerqua; Shaoping Guan; Xianlin Han; Richard W Gross
Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome.
Journal of lipid research 2013;54(5):1312-25.
2013: Andreu Viader; Cayce S Workman; Kui Yang; Richard W Gross; Sungsu Kim; Yo Sasaki; Amy Strickland; Jeffrey Milbrandt
Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.
Neuron 2013;77(5):886-98.
2012: Dipanjan Pan; Nibedita Sanyal; Anne H Schmieder; Angana Senpan; Samuel A Wickline; Xiaoxia Yang; John S Allen; Richard W Gross; Grace Hu; Benjamin Kim; Gregory M Lanza
Antiangiogenic nanotherapy with lipase-labile Sn-2 fumagillin prodrug.
Nanomedicine (London, England) 2012;7(10):1507-19.
2012: Sung Ho Moon; Harold F Sims; Christopher M Jenkins; Michael A Kiebish; david mancuso; Richard W Gross
Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release.
The Journal of biological chemistry 2012;287(35):29837-50.
2012: Michael A Kiebish; Xinping Liu; david mancuso; Harold F Sims; Kui Yang; Zhongdan Zhao; Dana R Abendschein; Shaoping Guan; Xianlin Han; Christopher M Jenkins; Richard W Gross
Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
The Journal of biological chemistry 2012;287(30):25086-97.
2012: Sung Ho Moon; Shaoping Guan; Christopher M Jenkins; Xinping Liu; david mancuso; Richard W Gross
Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.
The Journal of biological chemistry 2012;287(18):14880-95.
2011: Kui Yang; Xiaoling Fang; Richard W Gross; Xianlin Han
A practical approach for determination of mass spectral baselines.
Journal of the American Society for Mass Spectrometry 2011;22(11):2090-9.
2011: Kui Yang; Zhongdan Zhao; Richard W Gross; Xianlin Han
Identification and quantitation of unsaturated fatty acid isomers by electrospray ionization tandem mass spectrometry: a shotgun lipidomics approach.
Analytical chemistry 2011;83(11):4243-50.
2011: Richard W Gross; Xianlin Han
Lipidomics at the interface of structure and function in systems biology.
Chemistry & biology 2011;18(3):284-91.
2010: David J Mancuso; Harold F Sims; Kui Yang; Michael A Kiebish; Xiong Su; Christopher M Jenkins; Shaoping Guan; Sung Ho Moon; Terri Pietka; Fatiha Nassir; Timothy Schappe; Kristin Moore; Xianlin Han; Nada A Abumrad; Richard W Gross
Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
The Journal of biological chemistry 2010;285(47):36495-510.
2010: Michael A Kiebish; Rob Bell; Kui Yang; Toan Phan; Zhongdan Zhao; William Ames; Thomas N Seyfried; Richard W Gross; Jeffrey H Chuang; Xianlin Han
Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics.
Journal of lipid research 2010;51(8):2153-70.
2010: Hans H Dietrich; Dana R Abendschein; Sung Ho Moon; Neema Nayeb-Hashemi; david mancuso; Christopher M Jenkins; Kevin M Kaltenbronn; Kendall J Blumer; John Turk; Richard W Gross
Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.
American journal of physiology. Heart and circulatory physiology 2010;298(6):H2208-20.
2010: Hua Cheng; Gang Sun; Kui Yang; Richard W Gross; Xianlin Han
Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix.
Journal of lipid research 2010;51(6):1599-609.
2010: Meng Chen; Xiong Su; Jingyue Yang; Christopher M Jenkins; Ari M Cedars; Richard W Gross
Facile identification and quantitation of protein phosphorylation via beta-elimination and Michael addition with natural abundance and stable isotope labeled thiocholine.
Analytical chemistry 2010;82(1):163-71.
2009: david mancuso; PT Kotzbauer; David F Wozniak; Harold F Sims; Christopher M Jenkins; Shaoping Guan; Xianlin Han; Kui Yang; Gang Sun; Ibrahim Malik; Sara Conyers; Karen G Green; Robert E Schmidt; Richard W Gross
Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.
The Journal of biological chemistry 2009;284(51):35632-44.
2009: Kui Yang; Zhongdan Zhao; Richard W Gross; Xianlin Han
Systematic analysis of choline-containing phospholipids using multi-dimensional mass spectrometry-based shotgun lipidomics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(26):2924-36.
2009: Richard W Gross; Xianlin Han
Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E297-303.
2009: Kui Yang; Hua Cheng; Richard W Gross; Xianlin Han
Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics.
Analytical chemistry 2009;81(11):4356-68.
2009: Christopher M Jenkins; Ari Cedars; Richard W Gross
Eicosanoid signalling pathways in the heart.
Cardiovascular research 2009;82(2):240-9.
2009: Ari Cedars; Christopher M Jenkins; david mancuso; Richard W Gross
Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction.
Journal of cardiovascular pharmacology 2009;53(4):277-89.
2009: Matthew C Gropler; Thurl E Harris; Angela M Hall; Nathan E Wolins; Richard W Gross; Xianlin Han; Zhouji Chen; Brian N Finck
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
The Journal of biological chemistry 2009;284(11):6763-72.
2008: Gang Sun; Kui Yang; Zhongdan Zhao; Shaoping Guan; Xianlin Han; Richard W Gross
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte-matrix interactions.
Analytical chemistry 2008;80(19):7576-85.
2008: Xianlin Han; Kui Yang; Richard W Gross
Microfluidics-based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: development of an automated high-throughput platform for shotgun lipidomics.
Rapid communications in mass spectrometry : RCM 2008;22(13):2115-24.
2008: John J Lehman; Sihem Boudina; Natasha Hausler Banke; Nandakumar Sambandam; Xianlin Han; Deanna M Young; Teresa C Leone; Richard W Gross; E Douglas Lewandowski; E Dale Abel; Daniel P Kelly
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H185-96.
2008: hua cheng; david mancuso; Xuntian Jiang; Shaoping Guan; Jingyue Yang; Kui Yang; Gang Sun; Richard W Gross; Xianlin Han
Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.
Biochemistry 2008;47(21):5869-80.
2008: Ibrahim Malik; John Turk; david mancuso; Laura Montier; Mary Wohltmann; David F Wozniak; Robert E Schmidt; Richard W Gross; Paul T Kotzbauer
Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations.
The American journal of pathology 2008;172(2):406-16.
2007: Xuntian Jiang; hua cheng; Kui Yang; Richard W Gross; Xianlin Han
Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low-abundance regime of cellular sphingolipids.
Analytical biochemistry 2007;371(2):135-45.
2007: Eileen M Burkart; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Carolyn M Gierasch; Kooresh Shoghi; Michael J Welch; Daniel P Kelly
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart.
The Journal of clinical investigation 2007;117(12):3930-9.
2007: david mancuso; Harold F Sims; Xianlin Han; Christopher M Jenkins; Shao Ping Guan; Kui Yang; Sung Ho Moon; Terri Pietka; Nada A Abumrad; Paul H Schlesinger; Richard W Gross
Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
The Journal of biological chemistry 2007;282(48):34611-22.
2007: Gang Sun; Kui Yang; Zhongdan Zhao; Shaoping Guan; Xianlin Han; Richard W Gross
Shotgun metabolomics approach for the analysis of negatively charged water-soluble cellular metabolites from mouse heart tissue.
Analytical chemistry 2007;79(17):6629-40.
2007: Fatiha Nassir; Brody Wilson; Xianlin Han; Richard W Gross; Nada A Abumrad
CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine.
The Journal of biological chemistry 2007;282(27):19493-501.
2007: Xianlin Han; Jingyue Yang; Kui Yang; Zhongdan Zhao; Dana R Abendschein; Richard W Gross
Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes: a shotgun lipidomics study.
Biochemistry 2007;46(21):6417-28.
2007: John Yang; Nandakumar Sambandam; Xianlin Han; Richard W Gross; Michael Courtois; Attila Kovacs; Maria Febbraio; Brian N Finck; Daniel P Kelly
CD36 deficiency rescues lipotoxic cardiomyopathy.
Circulation research 2007;100(8):1208-17.
2007: david mancuso; Xianlin Han; Christopher M Jenkins; John J Lehman; Nandakumar Sambandam; Harold F Sims; Jingyue Yang; Wei Yan; Kui Yang; Karen Green; Dana R Abendschein; Jeffrey E Saffitz; Richard W Gross
Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
The Journal of biological chemistry 2007;282(12):9216-27.
2007: Kui Yang; Zhongdan Zhao; Richard W Gross; Xianlin Han
Shotgun lipidomics identifies a paired rule for the presence of isomeric ether phospholipid molecular species.
PloS one 2007;2(12):e1368.
2007: Richard W Gross; Xianlin Han
Lipidomics in diabetes and the metabolic syndrome.
Methods in enzymology 2007;433():73-90.
2006: Christopher M Jenkins; Wei Yan; david mancuso; Richard W Gross
Highly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity.
The Journal of biological chemistry 2006;281(23):15615-24.
2006: Xianlin Han; Kui Yang; Jingyue Yang; hua cheng; Richard W Gross
Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples.
Journal of lipid research 2006;47(4):864-79.
2006: Xianlin Han; Kui Yang; Jingyue Yang; Kora N Fikes; hua cheng; Richard W Gross
Factors influencing the electrospray intrasource separation and selective ionization of glycerophospholipids.
Journal of the American Society for Mass Spectrometry 2006;17(2):264-74.
2005: Xianlin Han; Jingyue Yang; hua cheng; Kui Yang; Dana R Abendschein; Richard W Gross
Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction.
Biochemistry 2005;44(50):16684-94.
2005: Dominique Langin; Andrea Dicker; Geneviève Tavernier; Johan Hoffstedt; Aline Mairal; Mikael Rydén; Erik Arner; Audrey Sicard; Christopher M Jenkins; Nathalie Viguerie; Vanessa van Harmelen; Richard W Gross; Cecilia Holm; Peter Arner
Adipocyte lipases and defect of lipolysis in human obesity.
Diabetes 2005;54(11):3190-7.
2005: Jingyue Yang; Beverly Gibson; Jacqueline Snider; Christopher M Jenkins; Xianlin Han; Richard W Gross
Submicromolar concentrations of palmitoyl-CoA specifically thioesterify cysteine 244 in glyceraldehyde-3-phosphate dehydrogenase inhibiting enzyme activity: a novel mechanism potentially underlying fatty acid induced insulin resistance.
Biochemistry 2005;44(35):11903-12.
2005: Richard W Gross; Christopher M Jenkins; Jingyue Yang; david mancuso; Xianlin Han
Functional lipidomics: the roles of specialized lipids and lipid-protein interactions in modulating neuronal function.
Prostaglandins & other lipid mediators 2005;77(1-4):52-64.
2005: Wei Yan; Christopher M Jenkins; Xianlin Han; david mancuso; Harold F Sims; Kui Yang; Richard W Gross
The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.
The Journal of biological chemistry 2005;280(29):26669-79.
2005: Xianlin Han; Kui Yang; hua cheng; Kora N Fikes; Richard W Gross
Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization.
Journal of lipid research 2005;46(7):1548-60.
2005: Xianlin Han; Richard W Gross
Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples.
Mass spectrometry reviews 2005;24(3):367-412.
2005: Rose A Gubitosi-Klug; david mancuso; Richard W Gross
The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):5964-8.
2005: Xiong Su; Xianlin Han; david mancuso; Dana R Abendschein; Richard W Gross
Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.
Biochemistry 2005;44(13):5234-45.
2005: Zhepeng Wang; Sasanka Ramanadham; Zhongmin Alex Ma; Shunzhong Bao; david mancuso; Richard W Gross; John Turk
Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.
The Journal of biological chemistry 2005;280(8):6840-9.
2004: Xianlin Han; hua cheng; david mancuso; Richard W Gross
Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium.
Biochemistry 2004;43(49):15584-94.
2004: david mancuso; Christopher M Jenkins; Harold F Sims; Joshua M Cohen; Jingyue Yang; Richard W Gross
Complex transcriptional and translational regulation of iPLAgamma resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization.
European journal of biochemistry / FEBS 2004;271(23-24):4709-24.
2004: Ian S Harris; Ilya Treskov; Michael W Rowley; Scott P Heximer; Kevin M Kaltenbronn; Brian N Finck; Richard W Gross; Daniel P Kelly; Kendall J Blumer; Anthony J Muslin
G-protein signaling participates in the development of diabetic cardiomyopathy.
Diabetes 2004;53(12):3082-90.
2004: Christopher M Jenkins; david mancuso; Wei Yan; Harold F Sims; Beverly Gibson; Richard W Gross
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
The Journal of biological chemistry 2004;279(47):48968-75.
2004: Xianlin Han; Jingyue Yang; hua cheng; Hongping Ye; Richard W Gross
Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry.
Analytical biochemistry 2004;330(2):317-31.
2004: Xiong Su; david mancuso; Perry E Bickel; Christopher M Jenkins; Richard W Gross
Small interfering RNA knockdown of calcium-independent phospholipases A2 beta or gamma inhibits the hormone-induced differentiation of 3T3-L1 preadipocytes.
The Journal of biological chemistry 2004;279(21):21740-8.
2004: Xiong Su; Xianlin Han; Jingyue Yang; david mancuso; Jeannie Chen; Perry E Bickel; Richard W Gross
Sequential ordered fatty acid alpha oxidation and Delta9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes.
Biochemistry 2004;43(17):5033-44.
2003: Elizabeth P Newberry; Yan Xie; Susan Kennedy; Xianlin Han; Kimberly Buhman; Jianyang Luo; Richard W Gross; Nicholas O Davidson
Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene.
The Journal of biological chemistry 2003;278(51):51664-72.
2003: Christopher M Jenkins; Xianlin Han; Jingyue Yang; david mancuso; Harold F Sims; Anthony J Muslin; Richard W Gross
Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis.
Biochemistry 2003;42(40):11798-807.
2003: Jingyue Yang; Xianlin Han; Richard W Gross
Identification of hepatic peroxisomal phospholipase A(2) and characterization of arachidonic acid-containing choline glycerophospholipids in hepatic peroxisomes.
FEBS letters 2003;546(2-3):247-50.
2003: david mancuso; Dana R Abendschein; Christopher M Jenkins; Xianlin Han; Jeffrey E Saffitz; Richard B Schuessler; Richard W Gross
Cardiac ischemia activates calcium-independent phospholipase A2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiologic phenotype by mechanism-based inhibition.
The Journal of biological chemistry 2003;278(25):22231-6.
2003: Brian N Finck; Xianlin Han; Michael Courtois; Franck Aimond; Jeanne M Nerbonne; Attila Kovacs; Richard W Gross; Daniel P Kelly
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1226-31.
2002: Paul E Glaser; Xianlin Han; Richard W Gross
Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: Implications for the coordinated regulation of glycolysis and membrane fusion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14104-9.
2002: Christopher M Jenkins; Xianlin Han; david mancuso; Richard W Gross
Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s.
The Journal of biological chemistry 2002;277(36):32807-14.
2002: Brian N Finck; John J Lehman; Teresa C Leone; Michael J Welch; Michael J Bennett; Attila Kovacs; Xianlin Han; Richard W Gross; Ray Kozak; Gary D Lopaschuk; Daniel P Kelly
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.
The Journal of clinical investigation 2002;109(1):121-30.
2001: Xianlin Han; Richard W Gross
Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry.
Analytical biochemistry 2001;295(1):88-100.
2001: Christopher M Jenkins; M J Wolf; david mancuso; Richard W Gross
Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta. implications for structure and function.
The Journal of biological chemistry 2001;276(10):7129-35.
2000: Xianlin Han; Dana R Abendschein; J G Kelley; Richard W Gross
Diabetes-induced changes in specific lipid molecular species in rat myocardium.
The Biochemical journal 2000;352 Pt 1():79-89.
2000: david mancuso; Christopher M Jenkins; Richard W Gross
The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2).
The Journal of biological chemistry 2000;275(14):9937-45.
1998: Xianlin Han; Sasanka Ramanadham; J Turk; Richard W Gross
Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes: catalysis by a protein constituent recognized by monoclonal antibodies directed against glyceraldehyde-3-phosphate dehydrogenase.
Biochimica et biophysica acta 1998;1414(1-2):95-107.
1998: Y Zeng; Xianlin Han; P Schlesinger; Richard W Gross
Nonesterified fatty acids induce transmembrane monovalent cation flux: host-guest interactions as determinants of fatty acid-induced ion transport.
Biochemistry 1998;37(26):9497-508.
1998: Y Zeng; Xianlin Han; Richard W Gross
Phospholipid subclass specific alterations in the passive ion permeability of membrane bilayers: separation of enthalpic and entropic contributions to transbilayer ion flux.
Biochemistry 1998;37(8):2346-55.
1997: M J Wolf; J Wang; John Turk; Richard W Gross
Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization.
The Journal of biological chemistry 1997;272(3):1522-6.
1996: R A Gubitosi-Klug; Richard W Gross
Fatty acid ethyl esters, nonoxidative metabolites of ethanol, accelerate the kinetics of activation of the human brain delayed rectifier K+ channel, Kv1.1.
The Journal of biological chemistry 1996;271(51):32519-22.
1996: M J Wolf; Richard W Gross
Expression, purification, and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2.
The Journal of biological chemistry 1996;271(48):30879-85.
1996: M J Wolf; Richard W Gross
The calcium-dependent association and functional coupling of calmodulin with myocardial phospholipase A2. Implications for cardiac cycle-dependent alterations in phospholipolysis.
The Journal of biological chemistry 1996;271(35):20989-92.
1996: David A Ford; X Han; C C Horner; Richard W Gross
Accumulation of unsaturated acylcarnitine molecular species during acute myocardial ischemia: metabolic compartmentalization of products of fatty acyl chain elongation in the acylcarnitine pool.
Biochemistry 1996;35(24):7903-9.
1996: X Han; R A Gubitosi-Klug; B J Collins; Richard W Gross
Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-induced platelet phospholipid hydrolysis.
Biochemistry 1996;35(18):5822-32.
1996: Sasanka Ramanadham; M J Wolf; Zhongmin Ma; B Li; J Wang; Richard W Gross; John Turk
Evidence for association of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein.
Biochemistry 1996;35(17):5464-71.
1996: Guim Kwon; Alan Bohrer; X Han; John A Corbett; Zhongmin Ma; Richard W Gross; Michael L McDaniel; John Turk
Characterization of the sphingomyelin content of isolated pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide.
Biochimica et biophysica acta 1996;1300(1):63-72.
1996: Zhongmin Ma; Sasanka Ramanadham; John A Corbett; Alan Bohrer; Richard W Gross; Michael L McDaniel; John Turk
Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism.
The Journal of biological chemistry 1996;271(2):1029-42.
1995: M J Wolf; Y Izumi; C F Zorumski; Richard W Gross
Long-term potentiation requires activation of calcium-independent phospholipase A2.
FEBS letters 1995;377(3):358-62.
1995: P E Glaser; Richard W Gross
Rapid plasmenylethanolamine-selective fusion of membrane bilayers catalyzed by an isoform of glyceraldehyde-3-phosphate dehydrogenase: discrimination between glycolytic and fusogenic roles of individual isoforms.
Biochemistry 1995;34(38):12193-203.
1995: Richard W Gross; A E Rudolph; J Wang; C D Sommers; M J Wolf
Nitric oxide activates the glucose-dependent mobilization of arachidonic acid in a macrophage-like cell line (RAW 264.7) that is largely mediated by calcium-independent phospholipase A2.
The Journal of biological chemistry 1995;270(25):14855-8.
1995: X Chen; Richard W Gross
Potassium flux through gramicidin ion channels is augmented in vesicles comprised of plasmenylcholine: correlations between gramicidin conformation and function in chemically distinct host bilayer matrices.
Biochemistry 1995;34(22):7356-64.
1995: R A Gubitosi-Klug; Shan Ping Yu; Dennis Choi; Richard W Gross
Concomitant acceleration of the activation and inactivation kinetics of the human delayed rectifier K+ channel (Kv1.1) by Ca(2+)-independent phospholipase A2.
The Journal of biological chemistry 1995;270(7):2885-8.
1994: X Chen; Richard W Gross
Phospholipid subclass-specific alterations in the kinetics of ion transport across biologic membranes.
Biochemistry 1994;33(46):13769-74.
1994: X Han; Richard W Gross
Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10635-9.
1994: Sasanka Ramanadham; M J Wolf; P A Jett; Richard W Gross; John Turk
Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor.
Biochemistry 1994;33(23):7442-52.
1994: K K Kruszka; Richard W Gross
The ATP- and CoA-independent synthesis of arachidonoylethanolamide. A novel mechanism underlying the synthesis of the endogenous ligand of the cannabinoid receptor.
The Journal of biological chemistry 1994;269(20):14345-8.
1994: P E Glaser; Richard W Gross
Plasmenylethanolamine facilitates rapid membrane fusion: a stopped-flow kinetic investigation correlating the propensity of a major plasma membrane constituent to adopt an HII phase with its ability to promote membrane fusion.
Biochemistry 1994;33(19):5805-12.
1994: S L Hazen; M J Wolf; David A Ford; Richard W Gross
The rapid and reversible association of phosphofructokinase with myocardial membranes during myocardial ischemia.
FEBS letters 1994;339(3):213-6.
1994: David A Ford; Richard W Gross
The discordant rates of sn-1 aliphatic chain and polar head group incorporation into plasmalogen molecular species demonstrate the fundamental importance of polar head group remodeling in plasmalogen metabolism in rabbit myocardium.
Biochemistry 1994;33(5):1216-22.
1993: Sasanka Ramanadham; Alan Bohrer; Richard W Gross; John Turk
Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes.
Biochemistry 1993;32(49):13499-509.
1993: J J Lehman; K A Brown; Sasanka Ramanadham; John Turk; Richard W Gross
Arachidonic acid release from aortic smooth muscle cells induced by [Arg8]vasopressin is largely mediated by calcium-independent phospholipase A2.
The Journal of biological chemistry 1993;268(28):20713-6.
1993: S L Hazen; C R Hall; David A Ford; Richard W Gross
Isolation of a human myocardial cytosolic phospholipase A2 isoform. Fast atom bombardment mass spectroscopic and reverse-phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates.
The Journal of clinical investigation 1993;91(6):2513-22.
1993: Sasanka Ramanadham; Alan Bohrer; M Mueller; P Jett; Richard W Gross; John Turk
Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.
Biochemistry 1993;32(20):5339-51.
1993: Stanley L Hazen; Richard W Gross
The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis.
The Journal of biological chemistry 1993;268(13):9892-900.
1993: John Turk; Richard W Gross; S Ramanadham
Amplification of insulin secretion by lipid messengers.
Diabetes 1993;42(3):367-74.
1993: Sasanka Ramanadham; Richard W Gross; X Han; John Turk
Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentration.
Biochemistry 1993;32(1):337-46.
1993: Richard W Gross; Sasanka Ramanadham; K K Kruszka; X Han; John Turk
Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells.
Biochemistry 1993;32(1):327-36.
1993: L A Zupan; R H Weiss; S L Hazen; B L Parnas; K W Aston; P J Lennon; Daniel P Getman; Richard W Gross
Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2.
Journal of medicinal chemistry 1993;36(1):95-100.
1992: R Miyake; Richard W Gross
Multiple phospholipase A2 activities in canine vascular smooth muscle.
Biochimica et biophysica acta 1992;1165(2):167-76.
1992: X Han; Richard W Gross
Nonmonotonic alterations in the fluorescence anisotropy of polar head group labeled fluorophores during the lamellar to hexagonal phase transition of phospholipids.
Biophysical journal 1992;63(2):309-16.
1992: David A Ford; K B Rosenbloom; Richard W Gross
The primary determinant of rabbit myocardial ethanolamine phosphotransferase substrate selectivity is the covalent nature of the sn-1 aliphatic group of diradyl glycerol acceptors.
The Journal of biological chemistry 1992;267(16):11222-8.
1992: L A Zupan; D L Steffens; C A Berry; M Landt; Richard W Gross
Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis.
The Journal of biological chemistry 1992;267(13):8707-10.
1992: Richard W Gross
Myocardial phospholipases A(2) and their membrane substrates.
Trends in cardiovascular medicine 1992;2(3):115-21.
1992: J H Pak; X Han; Richard W Gross
Differential molecular dynamics and transmembrane fluidity gradients in canine myocardial sarcolemma and sarcoplasmic reticulum.
Chemistry and physics of lipids 1992;61(2):111-9.
1992: S L Hazen; Richard W Gross
Identification and characterization of human myocardial phospholipase A2 from transplant recipients suffering from end-stage ischemic heart disease.
Circulation research 1992;70(3):486-95.
1992: X L Han; L A Zupan; S L Hazen; Richard W Gross
Semisynthesis and purification of homogeneous plasmenylcholine molecular species.
Analytical biochemistry 1992;200(1):119-24.
1991: X L Han; Richard W Gross
Alterations in membrane dynamics elicited by amphiphilic compounds are augmented in plasmenylcholine bilayers.
Biochimica et biophysica acta 1991;1069(1):37-45.
1991: S L Hazen; Richard W Gross
ATP-dependent regulation of rabbit myocardial cytosolic calcium-independent phospholipase A2.
The Journal of biological chemistry 1991;266(22):14526-34.
1991: David A Ford; S L Hazen; J E Saffitz; Richard W Gross
The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia.
The Journal of clinical investigation 1991;88(1):331-5.
1991: L A Zupan; K K Kruszka; Richard W Gross
Calcium is sufficient but not necessary for activation of sheep platelet cytosolic phospholipase A2.
FEBS letters 1991;284(1):27-30.
1991: S L Hazen; L A Zupan; R H Weiss; Daniel P Getman; Richard W Gross
Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2.
The Journal of biological chemistry 1991;266(11):7227-32.
1991: S L Hazen; David A Ford; Richard W Gross
Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate.
The Journal of biological chemistry 1991;266(9):5629-33.
1991: X L Han; Richard W Gross
Proton nuclear magnetic resonance studies on the molecular dynamics of plasmenylcholine/cholesterol and phosphatidylcholine/cholesterol bilayers.
Biochimica et biophysica acta 1991;1063(1):129-36.
1990: Y Miyazaki; Richard W Gross; B E Sobel; Jeffrey E Saffitz
Selective turnover of sarcolemmal phospholipids with lethal cardiac myocyte injury.
The American journal of physiology 1990;259(2 Pt 1):C325-31.
1990: X L Han; Richard W Gross
Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs.
Biochemistry 1990;29(20):4992-6.
1990: David A Ford; Richard W Gross
Activation of myocardial protein kinase C by plasmalogenic diglycerides.
The American journal of physiology 1990;258(1 Pt 1):C30-6.
1989: D A Ford; R Miyake; P E Glaser; Richard W Gross
Activation of protein kinase C by naturally occurring ether-linked diglycerides.
The Journal of biological chemistry 1989;264(23):13818-24.
1989: L A Scherrer; Richard W Gross
Subcellular distribution, molecular dynamics and catabolism of plasmalogens in myocardium.
Molecular and cellular biochemistry 1989;88(1-2):97-105.
1989: D A Ford; Richard W Gross
Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3479-83.
1989: D A Ford; Richard W Gross
Differential accumulation of diacyl and plasmalogenic diglycerides during myocardial ischemia.
Circulation research 1989;64(1):173-7.
1988: D A Ford; Richard W Gross
Identification of endogenous 1-O-alk-1'-enyl-2-acyl-sn-glycerol in myocardium and its effective utilization by choline phosphotransferase.
The Journal of biological chemistry 1988;263(6):2644-50.