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Frank Grosveld

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Rejane Hughes Carvalho; Frank Grosveld; Vanja Haberle; Jun Hou; Boris Lenhard; Joachim Aerts; Sjaak Philipsen
Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas.
Farzin Pourfarzad; Wilfred van Ijcken; Marieke von Lindern; Azita Azarkeivan; Fatemehsadat Esteghamat; Jun Hou; Sima Kheradmand Kia; Hossein Najmabadi; Sjaak Philipsen; Frank Grosveld
Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.
Athina Mylona; Eric Soler; Supat Thongjuea; Wilfred van Ijcken; Jun Hou; Ruud Jorna; Christel Kockx; Boris Lenhard; Andrea Martella; Charlotte Andrieu-Soler; Frank Grosveld
Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis.

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All Publications

2013: Rejane Hughes Carvalho; Frank Grosveld; Vanja Haberle; Jun Hou; Boris Lenhard; Joachim Aerts; Sjaak Philipsen
Genomewide DNA methylation analysis identifies novel methylated genes in non-small-cell lung carcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(5):562-73.
2013: Farzin Pourfarzad; Wilfred van Ijcken; Marieke von Lindern; Azita Azarkeivan; Fatemehsadat Esteghamat; Jun Hou; Sima Kheradmand Kia; Hossein Najmabadi; Sjaak Philipsen; Frank Grosveld
Hydroxyurea responsiveness in β-thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity.
Haematologica 2013;98(5):696-704.
2013: Athina Mylona; Eric Soler; Supat Thongjuea; Wilfred van Ijcken; Jun Hou; Ruud Jorna; Christel Kockx; Boris Lenhard; Andrea Martella; Charlotte Andrieu-Soler; Frank Grosveld
Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis.
Blood 2013;121(15):2902-13.
2013: Fatemehsadat Esteghamat; Nynke Gillemans; Frank Grosveld; Ursula Klingmüller; Ivan Bilic; Thamar Bryn van Dijk; Meinrad Busslinger; Ileana Cantù; Emile van den Akker; Teus van Gent; Kirsten van Lom; Marieke von Lindern; Sjaak Philipsen
Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
Blood 2013;121(13):2553-62.
2013: Ralph Stadhouders; Anita van den Heuvel; Wilfred van Ijcken; Kerstin S Wendt; Jessica Zuin; Rutger Brouwer; Frank Grosveld; Christel Kockx; Petros Kolovos; Robert-Jan Palstra; Eric Soler
Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions.
Nature protocols 2013;8(3):509-24.
2013: Yadi Huang; Joshua Kapere Ochieng; Marjon Buscop-van Kempen; Anne Boerema-de Munck; SM Swagemakers; Dick Tibboel; Wilfred van Ijcken; Frank Grosveld; Robbert Rottier
Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.
PloS one 2013;8(2):e57695.
2012: Lalini Raghoebir; Ron Smits; SM Swagemakers; Dick Tibboel; Elvira R M Bakker; Siska Driegen; Frank Grosveld; Marjon Buscop-van Kempen; Dies Meijer; Jason C Mills; Anne Boerema-de Munck; Robbert Rottier
SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.
Journal of molecular cell biology 2012;4(6):377-85.
2012: Pavlos Fanis; Nynke Gillemans; Frank Grosveld; Sjaak Philipsen; Farzin Pourfarzad; Ratna K Vadlamudi; Ali Aghajanirefah; Jeroen A A Demmers; Fatemehsadat Esteghamat; Thamar B van Dijk
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Molecular & cellular proteomics : MCP 2012;11(11):1263-73.
2012: Ksenija Drabek; Umut Akinci; Jean-Charles Boisset; Thomas Clapes; Dubravka Drabek; Frank Grosveld; Laura Gutiérrez; Rudi W Hendriks; Joseph E Italiano; Zhe Liu; Helder Maiato; Marjolein Meinders; Clara Melo; Mieke Mommaas; Tatjana Nikolic; Sunita R Patel; Ana L Pereira; Sjaak Philipsen; Catherine Robin; Clara Sambade; Mirjam van den Hout; Jeffrey van Haren; Wilfred van Ijcken; Marcel Vermeij; Niels Galjart
The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance.
Cell reports 2012;2(4):781-8.
2012: Boet van Riel; Charlotte Andrieu-Soler; Rutger Brouwer; Jan Christian Bryne; Jeroen A A Demmers; Vedran Franke; Ruud Jorna; Boris Lenhard; Rui Monteiro; Tibor Pakozdi; Roger Patient; Erik-Jan Rijkers; Eric Soler; Kapil Tuladhar; Wilfred van Ijcken; Frank Grosveld
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
Molecular and cellular biology 2012;32(19):3814-22.
2012: Ralph Stadhouders; Anita van den Heuvel; Frank Grosveld; Ruud Jorna; Petros Kolovos; Kris Leslie; Eric Soler
Transcription regulation by distal enhancers: who's in the loop?
Transcription 2012;3(4):181-6.
2012: Ralph Stadhouders; Mary Stevens; Supat Thongjuea; Anita van den Heuvel; Mirjam van den Hout; Antoine van der Sloot; Wilfred van Ijcken; Charlotte Andrieu-Soler; Jan Christian Bryne; Ernie de Boer; Dirk Eick; Frank Grosveld; Christel Kockx; Boris Lenhard; Robert-Jan Palstra; Eric Soler
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development.
The EMBO journal 2012;31(4):986-99.
2012: Yadi Huang; Marjon Buscop-van Kempen; Poornima Mahavadi; Dies Meijer; Anne Boerema-de Munck; SM Swagemakers; Dick Tibboel; Peter van der Spek; Wilfred van Ijcken; Siska Driegen; Frank Grosveld; Andreas Günther; Robbert Rottier
Hypoxia-inducible factor 2α plays a critical role in the formation of alveoli and surfactant.
American journal of respiratory cell and molecular biology 2012;46(2):224-32.
2012: Petros Papadopoulos; George P Patrinos; Sjaak Philipsen; Reinier van der Linden; Dubravka Drabek; Laura Gutiérrez; John Kong-A-San; Alex Maas; Frank Grosveld
A dual reporter mouse model of the human β-globin locus: applications and limitations.
PloS one 2012;7(12):e51272.
2012: Robert-Jan Palstra; Frank Grosveld
Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux.
Frontiers in genetics 2012;3():195.
2012: Frank Sleutels; Widia Soochit; Suzanne van de Nobelen; Michael van der Reijden; Wilfred van Ijcken; J Anton Grootegoed; Frank Grosveld; Helen Heath; Boris Lenhard; Rainer Renkawitz; Manuel Rosa-Garrido; Marek Bartkuhn; Philipp Bergmaier; Jan Christian Bryne; Lisa Caesar; M Dolores Delgado; Sven Dienstbach; Vedran Franke; Niels Galjart
The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.
Epigenetics & chromatin 2012;5(1):8.
2011: Claudia Ribeiro de Almeida; Eric Soler; Ralph Stadhouders; Supat Thongjuea; Wilfred van Ijcken; Ingrid M Bergen; Marjolein J W de Bruijn; Niels Galjart; Frank Grosveld; Boris Lenhard; Rudi W Hendriks
The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus.
Immunity 2011;35(4):501-13.
2011: Susanna Porcu; Valeria Sogos; Isadora Asunis; Antonio Cao; Frank Grosveld; Maria F Manchinu; Maria G Marini; Maria Franca Marongiu; Paolo Moi; Daniela Poddie; Loredana Porcu; Maria Serafina Ristaldi
Klf1 affects DNase II-alpha expression in the central macrophage of a fetal liver erythroblastic island: a non-cell-autonomous role in definitive erythropoiesis.
Molecular and cellular biology 2011;31(19):4144-54.
2011: Shuaiying Cui; Jeroen A A Demmers; James Douglas Engel; Frank Grosveld; Katarzyna E Kolodziej; Naoshi Obara; Lihong Shi; John Strouboulis; Alexandra Amaral-Psarris; Osamu Tanabe
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.
Molecular and cellular biology 2011;31(16):3298-311.
2011: Noorjahan Jagalur Basheer; Erin A Jones; Alex Maas; Wim Mandemakers; Siska Driegen; Mehrnaz Ghazvini; Frank Grosveld; Martine Jaegle; John Svaren; Dies Meijer
Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(23):8585-94.
2011: Eric Soler; Charlotte Andrieu-Soler; Ernie de Boer; Jan Christian Bryne; Supat Thongjuea; Erikjan Rijkers; Jeroen Demmers; Wilfred van Ijcken; Frank Grosveld
A systems approach to analyze transcription factors in mammalian cells.
Methods (San Diego, Calif.) 2011;53(2):151-62.
2010: Thamar Bryn van Dijk; Nynke Gillemans; Farzin Pourfarzad; Kirsten van Lom; Marieke von Lindern; Frank Grosveld; Sjaak Philipsen
Fetal globin expression is regulated by Friend of Prmt1.
Blood 2010;116(20):4349-52.
2010: Tatiana Stepanova; Ihor Smal; Jeffrey van Haren; Umut Akinci; Zhe Liu; Marja Miedema; Ronald Limpens; Marco van Ham; Michael van der Reijden; Raymond Poot; Frank Grosveld; Mieke Mommaas; Erik Meijering; Niels Galjart
History-dependent catastrophes regulate axonal microtubule behavior.
Current biology : CB 2010;20(11):1023-8.
2010: Eric Soler; Charlotte Andrieu-Soler; Ernie de Boer; Jan Christian Bryne; Supat Thongjuea; Ralph Stadhouders; Robert-Jan Palstra; Mary Stevens; Christel Kockx; Wilfred van Ijcken; Jun Hou; Christine Steinhoff; Erikjan Rijkers; Boris Lenhard; Frank Grosveld
The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation.
Genes & development 2010;24(3):277-89.
2010: Suzanne van de Nobelen; Manuel Rosa-Garrido; Jörg Leers; Helen Heath; Widia Soochit; Linda Joosen; Iris Jonkers; Jeroen Demmers; Michael van der Reijden; Verónica Torrano; Frank Grosveld; M Dolores Delgado; Rainer Renkawitz; Niels Galjart; Frank Sleutels
CTCF regulates the local epigenetic state of ribosomal DNA repeats.
Epigenetics & chromatin 2010;3(1):19.
2010: Jun Hou; Joachim Aerts; Bianca den Hamer; Wilfred van Ijcken; Michael A Den Bakker; Peter Riegman; Cor van der Leest; Peter van der Spek; John A Foekens; Henk C Hoogsteden; Frank Grosveld; Sjaak Philipsen
Gene expression-based classification of non-small cell lung carcinomas and survival prediction.
PloS one 2010;5(4):e10312.
2010: Ton de Wit; Sylvia Dekker; Alex Maas; Guido Breedveld; Tobias A Knoch; An Langeveld; Dorota Szumska; Roger Craig; Shoumo Bhattacharya; Frank Grosveld; Dubravka Drabek
Tagged mutagenesis by efficient Minos-based germ line transposition.
Molecular and cellular biology 2010;30(1):68-77.
2010: Thamar B van Dijk; Nynke Gillemans; Claudia Stein; Pavlos Fanis; Jeroen A A Demmers; Mariëtte van de Corput; Jeroen Essers; Frank Grosveld; Uta-Maria Bauer; Sjaak Philipsen
Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
Molecular and cellular biology 2010;30(1):260-72.
2009: Iris Jonkers; Tahsin Stefan Barakat; Eskeatnaf Mulugeta Achame; Kim Monkhorst; Annegien Kenter; Eveline Rentmeester; Frank Grosveld; J Anton Grootegoed; Joost Gribnau
RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation.
Cell 2009;139(5):999-1011.
2009: Rien van Haperen; Hannelore Samyn; Teus van Gent; Adri J Zonneveld; matthijs moerland; Frank Grosveld; Hans Jansen; Geesje M Dallinga-Thie; Arie Van Tol; Rini de Crom
Novel roles of hepatic lipase and phospholipid transfer protein in VLDL as well as HDL metabolism.
Biochimica et biophysica acta 2009;1791(10):1031-6.
2009: Jeffrey van Haren; Katharina Dragestein; Nanda Keijzer; Jan Pieter Abrahams; Frank Grosveld; Pieter Johan Peeters; Dieder Moechars; Niels Galjart
Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions.
Cell motility and the cytoskeleton 2009;66(10):824-38.
2009: Hannelore Samyn; matthijs moerland; Teus van Gent; Rien van Haperen; Frank Grosveld; Arie Van Tol; Rini de Crom
Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice.
Atherosclerosis 2009;204(2):429-34.
2009: Claudia Ribeiro de Almeida; Helen Heath; Sanja Krpic; Gemma M Dingjan; Jan Piet Van Hamburg; Ingrid Bergen; Suzanne van de Nobelen; Frank Sleutels; Frank Grosveld; Niels Galjart; Rudolf W Hendriks
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):999-1010.
2009: Kim Monkhorst; Bas de Hoon; Iris Jonkers; Eskeatnaf Mulugeta Achame; Wouter Monkhorst; Jos W Hoogerbrugge; Eveline Rentmeester; Hans V Westerhoff; Frank Grosveld; J Anton Grootegoed; Joost Gribnau
The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.
PloS one 2009;4(5):e5616.
2009: Katarzyna E Kolodziej; Farzin Pourfarzad; Ernie de Boer; Sanja Krpic; Frank Grosveld; John Strouboulis
Optimal use of tandem biotin and V5 tags in ChIP assays.
BMC molecular biology 2009;10():6.
2008: Hannelore Samyn; matthijs moerland; Teus van Gent; Rien van Haperen; Jari Metso; Frank Grosveld; Matti Jauhiainen; Arie Van Tol; Rini de Crom
Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study.
Journal of lipid research 2008;49(12):2504-12.
2008: Helen Heath; Claudia Ribeiro de Almeida; Frank Sleutels; Gemma Dingjan; Suzanne van de Nobelen; Iris Jonkers; Kam-Wing Ling; Joost Gribnau; Rainer Renkawitz; Frank Grosveld; Rudolf W Hendriks; Niels Galjart
CTCF regulates cell cycle progression of alphabeta T cells in the thymus.
The EMBO journal 2008;27(21):2839-50.
2008: Iris Jonkers; Kim Monkhorst; Eveline Rentmeester; J Anton Grootegoed; Frank Grosveld; Joost Gribnau
Xist RNA is confined to the nuclear territory of the silenced X chromosome throughout the cell cycle.
Molecular and cellular biology 2008;28(18):5583-94.
2008: matthijs moerland; Hannelore Samyn; Teus van Gent; Rien van Haperen; Geesje M Dallinga-Thie; Frank Grosveld; Arie Van Tol; Rini de Crom
Acute elevation of plasma PLTP activity strongly increases pre-existing atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1277-82.
2008: Cristina Gontan; Anne de Munck; Marcel Vermeij; Frank Grosveld; Dick Tibboel; Robbert Rottier
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.
Developmental biology 2008;317(1):296-309.
2008: Katharina Dragestein; Wiggert A van Cappellen; Jeffrey van Haren; george tsibidis; Anna Akhmanova; Tobias A Knoch; Frank Grosveld; Niels Galjart
Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends.
The Journal of cell biology 2008;180(4):729-37.
2008: Kim Monkhorst; Iris Jonkers; Eveline Rentmeester; Frank Grosveld; Joost Gribnau
X inactivation counting and choice is a stochastic process: evidence for involvement of an X-linked activator.
Cell 2008;132(3):410-21.
2008: Rien van Haperen; Hannelore Samyn; matthijs moerland; Teus van Gent; Marian Peeters; Frank Grosveld; Arie Van Tol; Rini de Crom
Elevated expression of phospholipid transfer protein in bone marrow derived cells causes atherosclerosis.
PloS one 2008;3(5):e2255.
2008: Wouter de Laat; Petra Klous; Jurgen Kooren; Daan Noordermeer; Robert-Jan Palstra; Marieke Simonis; Erik Splinter; Frank Grosveld
Three-dimensional organization of gene expression in erythroid cells.
Current topics in developmental biology 2008;82():117-39.
2008: Robert-Jan Palstra; Wouter de Laat; Frank Grosveld
Beta-globin regulation and long-range interactions.
Advances in genetics 2008;61():107-42.
2007: Pieter Fokko Van Loo; Edris A F Mahtab; Lambertus J Wisse; Jun Hou; Frank Grosveld; Guntram Suske; Sjaak Philipsen; Adriana C Gittenberger-De Groot
Transcription factor Sp3 knockout mice display serious cardiac malformations.
Molecular and cellular biology 2007;27(24):8571-82.
2007: matthijs moerland; Hannelore Samyn; Teus van Gent; Matti Jauhiainen; Jari Metso; Rien van Haperen; Frank Grosveld; Arie Van Tol; Rini de Crom
Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice.
Journal of lipid research 2007;48(12):2622-31.
2007: Adamantia Papachatzopoulou; Polynikis Kaimakis; Farzin Pourfarzad; Panayiotis G Menounos; Panagiota Evangelakou; Panagoula Kollia; Frank Grosveld; George P Patrinos
Increased gamma-globin gene expression in beta-thalassemia intermedia patients correlates with a mutation in 3'HS1.
American journal of hematology 2007;82(11):1005-9.
2007: Wouter de Laat; Frank Grosveld
Inter-chromosomal gene regulation in the mammalian cell nucleus.
Current opinion in genetics & development 2007;17(5):456-64.
2007: Laura Gutiérrez; Tatjana Nikolic; Thamar B van Dijk; Hamida Hammad; Nanda Vos; Monique Willart; Frank Grosveld; Sjaak Philipsen; Bart N Lambrecht
Gata1 regulates dendritic-cell development and survival.
Blood 2007;110(6):1933-41.
2007: Ilya Grigoriev; Daniël Splinter; Nanda Keijzer; Phebe Wulf; Jeroen A A Demmers; Toshihisa Ohtsuka; Mauro Modesti; Ivan V Maly; Frank Grosveld; Casper C Hoogenraad; Anna Akhmanova
Rab6 regulates transport and targeting of exocytotic carriers.
Developmental cell 2007;13(2):305-14.
2007: matthijs moerland; Nora Anghelescu; Hannelore Samyn; Rien van Haperen; Teus van Gent; John Strouboulis; Arie Van Tol; Frank Grosveld; Rini de Crom
Inducible expression of phospholipid transfer protein (PLTP) in transgenic mice: acute effects of PLTP on lipoprotein metabolism.
Transgenic research 2007;16(4):503-13.
2007: Rita Ferreira; Albert W K Wai; Ritsuko Shimizu; Nynke Gillemans; Robbert Rottier; Marieke von Lindern; Kinuko Ohneda; Frank Grosveld; Masayuki Yamamoto; Sjaak Philipsen
Dynamic regulation of Gata factor levels is more important than their identity.
Blood 2007;109(12):5481-90.
2007: Jurgen Kooren; Robert-Jan Palstra; Petra Klous; Erik Splinter; Marieke von Lindern; Frank Grosveld; Wouter de Laat
Beta-globin active chromatin Hub formation in differentiating erythroid cells and in p45 NF-E2 knock-out mice.
The Journal of biological chemistry 2007;282(22):16544-52.
2007: Marie-Liesse Asselin-Labat; Kate D Sutherland; Holly Barker; Richard Thomas; Mark Shackleton; Natasha C Forrest; Lynne Hartley; Lorraine Robb; Frank Grosveld; Jacqueline van der Wees; Geoffrey J Lindeman; Jane E Visvader
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.
Nature cell biology 2007;9(2):201-9.
2007: Maria Markaki; Dubravka Drabek; Ioannis Livadaras; Roger K Craig; Frank Grosveld; Charalambos Savakis
Stable expression of human growth hormone over 50 generations in transgenic insect larvae.
Transgenic research 2007;16(1):99-107.
2007: Eleni Z Katsantoni; Nora E Anghelescu; Robbert Rottier; matthijs moerland; Michael Antoniou; Rini de Crom; Frank Grosveld; John Strouboulis
Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island.
BMC developmental biology 2007;7():108.
2007: Dorota Kurek; george garinis; J Hikke van Doorninck; Jacqueline van der Wees; Frank Grosveld
Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.
Development (Cambridge, England) 2007;134(2):261-72.
2006: Natalia Meier; Sanja Krpic; Patrick Rodriguez; John Strouboulis; Maria Monti; Jeroen Krijgsveld; Martin Gering; Roger Patient; Arnd Hostert; Frank Grosveld
Novel binding partners of Ldb1 are required for haematopoietic development.
Development (Cambridge, England) 2006;133(24):4913-23.
2006: Ksenija Drabek; Marco van Ham; Tatiana Stepanova; Katharina Dragestein; Remco van Horssen; Carmen Laura Sayas; Anna Akhmanova; Timo L M ten Hagen; Ron Smits; Riccardo Fodde; Frank Grosveld; Niels Galjart
Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.
Current biology : CB 2006;16(22):2259-64.
2006: Rick Janssens; Sylvia Dekker; Rudolf W Hendriks; George Panayotou; Alexandra Van Remoortere; John Kong-a San; Frank Grosveld; Dubravka Drabek
Generation of heavy-chain-only antibodies in mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15130-5.
2006: Erik Splinter; Helen Heath; Jurgen Kooren; Robert-Jan Palstra; Petra Klous; Frank Grosveld; Niels Galjart; Wouter de Laat
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus.
Genes & development 2006;20(17):2349-54.
2006: Gideon Lansbergen; Ilya Grigoriev; Yuko Mimori-Kiyosue; Toshihisa Ohtsuka; Susumu Higa; Isao Kitajima; Jeroen A A Demmers; Niels Galjart; Adriaan B Houtsmuller; Frank Grosveld; Anna Akhmanova
CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.
Developmental cell 2006;11(1):21-32.
2006: caroline cheng; Dennie Tempel; Rien van Haperen; Arjen van der Baan; Frank Grosveld; Mat J A P Daemen; Rob Krams; Rini de Crom
Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress.
Circulation 2006;113(23):2744-53.
2006: Jennifer L Y Tam; Kostas Triantaphyllopoulos; Helen Todd; Selina Raguz; Ton de Wit; Jennifer E Morgan; Terence A Partridge; Eleni Makrinou; Frank Grosveld; Michael Antoniou
The human desmin locus: gene organization and LCR-mediated transcriptional control.
Genomics 2006;87(6):733-46.
2006: Pascal van der Wegen; Rogier Louwen; Ali M Imam; Ruvalic M Buijs-Offerman; Maarten Sinaasappel; Frank Grosveld; Bob J Scholte
Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(2):374-81.
2006: Patrick Rodriguez; Harald Braun; Katarzyna E Kolodziej; Ernie de Boer; Jennifer Campbell; Edgar Bonte; Frank Grosveld; Sjaak Philipsen; John Strouboulis
Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads.
Methods in molecular biology (Clifton, N.J.) 2006;338():305-23.
2006: Sebastiaan Horsman; Michael J Moorhouse; Victor C L de Jager; Peter van der Spek; Frank Grosveld; John Strouboulis; Eleni Z Katsantoni
TF Target Mapper: a BLAST search tool for the identification of Transcription Factor target genes.
BMC bioinformatics 2006;7():120.
2005: Yulia Komarova; Gideon Lansbergen; Niels Galjart; Frank Grosveld; Gary G Borisy; Anna Akhmanova
EB1 and EB3 control CLIP dissociation from the ends of growing microtubules.
Molecular biology of the cell 2005;16(11):5334-45.
2005: Anna Akhmanova; Anne-Laure Mausset-Bonnefont; Wiggert A van Cappellen; Nanda Keijzer; Casper C Hoogenraad; Tatiana Stepanova; Ksenija Drabek; Jacqueline van der Wees; Mieke Mommaas; Jos J M Onderwater; Hans van der Meulen; Marvin Tanenbaum; René H Medema; Jos W Hoogerbrugge; Jan Vreeburg; Evert-Jan Uringa; J Anton Grootegoed; Frank Grosveld; Niels Galjart
The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.
Genes & development 2005;19(20):2501-15.
2005: Laura Gutiérrez; Fokke Lindeboom; Rita Ferreira; Roy Drissen; Frank Grosveld; David Whyatt; Sjaak Philipsen
A hanging drop culture method to study terminal erythroid differentiation.
Experimental hematology 2005;33(10):1083-91.
2005: Siska Driegen; Rita Ferreira; Arend van Zon; John Strouboulis; Martine Jaegle; Frank Grosveld; Sjaak Philipsen; Dies Meijer
A generic tool for biotinylation of tagged proteins in transgenic mice.
Transgenic research 2005;14(4):477-82.
2005: Patrick Rodriguez; Edgar Bonte; Jeroen Krijgsveld; Katarzyna E Kolodziej; Boris Guyot; albert heck; Paresh Vyas; Ernie de Boer; Frank Grosveld; John Strouboulis
GATA-1 forms distinct activating and repressive complexes in erythroid cells.
The EMBO journal 2005;24(13):2354-66.
2005: Roy Drissen; Marieke von Lindern; Andrea Kolbus; Siska Driegen; Peter Steinlein; Hartmut Beug; Frank Grosveld; Sjaak Philipsen
The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.
Molecular and cellular biology 2005;25(12):5205-14.
2005: Yuko Mimori-Kiyosue; Ilya Grigoriev; Gideon Lansbergen; Hiroyuki Sasaki; Chiyuki Matsui; Fedor Severin; Niels Galjart; Frank Grosveld; Ivan A Vorobjev; Shoichiro Tsukita; Anna Akhmanova
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.
The Journal of cell biology 2005;168(1):141-53.
2005: Frank Grosveld; Patrick Rodriguez; Natalia Meier; Sanja Krpic; Farzin Pourfarzad; Petros Papadopoulos; Katarzyna E Kolodziej; George P Patrinos; Arnd Hostert; John Strouboulis
Isolation and characterization of hematopoietic transcription factor complexes by in vivo biotinylation tagging and mass spectrometry.
Annals of the New York Academy of Sciences 2005;1054():55-67.
2005: Marta Canis Parera; Marieke van Dooren; Marjon van Kempen; Ronald R de Krijger; Frank Grosveld; Dick Tibboel; Robbert Rottier
Distal angiogenesis: a new concept for lung vascular morphogenesis.
American journal of physiology. Lung cellular and molecular physiology 2005;288(1):L141-9.
2004: Roy Drissen; Robert-Jan Palstra; Nynke Gillemans; Erik Splinter; Frank Grosveld; Sjaak Philipsen; Wouter de Laat
The active spatial organization of the beta-globin locus requires the transcription factor EKLF.
Genes & development 2004;18(20):2485-90.
2004: Gideon Lansbergen; Yulia Komarova; Mauro Modesti; Claire Wyman; Casper C Hoogenraad; Holly V Goodson; Régis P Lemaitre; David N Drechsel; Erik van Munster; Theodorus W J Gadella; Frank Grosveld; Niels Galjart; Gary G Borisy; Anna Akhmanova
Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization.
The Journal of cell biology 2004;166(7):1003-14.
2004: Aysel Darbas; Martine Jaegle; Erik T Walbeehm; Hans van den Burg; Siska Driegen; Ludo Broos; Matthijs Uyl; Pim Visser; Frank Grosveld; Dies Meijer
Cell autonomy of the mouse claw paw mutation.
Developmental biology 2004;272(2):470-82.
2004: Laura Gutiérrez; Fokke Lindeboom; An Langeveld; Frank Grosveld; Sjaak Philipsen; David Whyatt
Homotypic signalling regulates Gata1 activity in the erythroblastic island.
Development (Cambridge, England) 2004;131(13):3183-93.
2004: George P Patrinos; Mariken de Krom; Ernie de Boer; An Langeveld; A M Ali Imam; John Strouboulis; Wouter de Laat; Frank Grosveld
Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.
Genes & development 2004;18(12):1495-509.
2004: Jacqueline van der Wees; Marjolein A J van Looij; Martijn M de Ruiter; Helineth Elias; Hans van der Burg; Su-San Liem; Dorota Kurek; James Douglas Engel; Alar Karis; Bert G A Van Zanten; Chris I De Zeeuw; Frank Grosveld; J Hikke van Doorninck
Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder.
Neurobiology of disease 2004;16(1):169-78.
2004: Eleni Z Katsantoni; Mariken de Krom; John Kong-A-San; A M Ali Imam; Frank Grosveld; Nicholas P Anagnou; John Strouboulis
An embryonic-specific repressor element located 3' to the Agamma-globin gene influences transcription of the human beta-globin locus in transgenic mice.
Experimental hematology 2004;32(2):224-33.
2004: Erik Splinter; Frank Grosveld; Wouter de Laat
3C technology: analyzing the spatial organization of genomic loci in vivo.
Methods in enzymology 2004;375():493-507.
2003: Casper C Hoogenraad; Phebe Wulf; Natalia Schiefermeier; Tatiana Stepanova; Niels Galjart; J Victor Small; Frank Grosveld; Chris I De Zeeuw; Anna Akhmanova
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport.
The EMBO journal 2003;22(22):6004-15.
2003: Sylvia Dekker; Wendy Toussaint; George Panayotou; Ton de Wit; Pim Visser; Frank Grosveld; Dubravka Drabek
Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses.
Journal of virology 2003;77(22):12132-9.
2003: Eleni Z Katsantoni; An Langeveld; Albert W K Wai; Dubravka Drabek; Frank Grosveld; Nicholas P Anagnou; John Strouboulis
Persistent gamma-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences.
Blood 2003;102(9):3412-9.
2003: Robert-Jan Palstra; Bas Tolhuis; Erik Splinter; Rian Nijmeijer; Frank Grosveld; Wouter de Laat
The beta-globin nuclear compartment in development and erythroid differentiation.
Nature genetics 2003;35(2):190-4.
2003: Fokke Lindeboom; Nynke Gillemans; Alar Karis; Martine Jaegle; Dies Meijer; Frank Grosveld; Sjaak Philipsen
A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse.
Nucleic acids research 2003;31(18):5405-12.
2003: Albert W K Wai; Nynke Gillemans; Selina Raguz-Bolognesi; Sara Pruzina; Gaetano Zafarana; Dies Meijer; Sjaak Philipsen; Frank Grosveld
HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells.
The EMBO journal 2003;22(17):4489-500.
2003: Pieter Fokko Van Loo; Peter Bouwman; Kam-Wing Ling; Sabine Middendorp; Guntram Suske; Frank Grosveld; Elaine Dzierzak; Sjaak Philipsen; Rudolf W Hendriks
Impaired hematopoiesis in mice lacking the transcription factor Sp3.
Blood 2003;102(3):858-66.
2003: Ernie de Boer; Patrick Rodriguez; Edgar Bonte; Jeroen Krijgsveld; Eleni Z Katsantoni; Albert Heck; Frank Grosveld; John Strouboulis
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7480-5.
2003: Martine Jaegle; Mehrnaz Ghazvini; Wim Mandemakers; Marko Piirsoo; Siska Driegen; Francoise Levavasseur; Smiriti Raghoenath; Frank Grosveld; Dies Meijer
The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.
Genes & development 2003;17(11):1380-91.
2003: Tatiana Stepanova; Jennifer E Slemmer; Casper C Hoogenraad; Gideon Lansbergen; Bjorn Dortland; Chris I De Zeeuw; Frank Grosveld; Gert van Cappellen; Anna Akhmanova; Niels Galjart
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(7):2655-64.
2003: Nynke Gillemans; Tara McMorrow; Rita Tewari; Albert W K Wai; Carola Burgtorf; Dubravka Drabek; Nicki Ventress; An Langeveld; Douglas Higgs; Kian-Cheng Tan-Un; Frank Grosveld; Sjaak Philipsen
Functional and comparative analysis of globin loci in pufferfish and humans.
Blood 2003;101(7):2842-9.
2003: Dubravka Drabek; Laskaro Zagoraiou; Ton deWit; An Langeveld; Chariklea Roumpaki; Clio Mamalaki; Charalambos Savakis; Frank Grosveld
Transposition of the Drosophila hydei Minos transposon in the mouse germ line.
Genomics 2003;81(2):108-11.
2003: Wouter de Laat; Frank Grosveld
Spatial organization of gene expression: the active chromatin hub.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2003;11(5):447-59.
2002: Rien van Haperen; Arie Van Tol; Teus van Gent; Leo Scheek; Pim Visser; Arthur van der Kamp; Frank Grosveld; Rini de Crom
Increased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein.
The Journal of biological chemistry 2002;277(50):48938-43.
2002: Rien van Haperen; Monique de Waard; Elza D van Deel; Barend Mees; Michael J B Kutryk; Thijs van Aken; Jaap Hamming; Frank Grosveld; Dirk J Duncker; Rini de Crom
Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide.
The Journal of biological chemistry 2002;277(50):48803-7.
2002: Bas Tolhuis; Robert-Jan Palstra; Erik Splinter; Frank Grosveld; Wouter de Laat
Looping and interaction between hypersensitive sites in the active beta-globin locus.
Molecular cell 2002;10(6):1453-65.
2002: Theodoros Matanis; Anna Akhmanova; Phebe Wulf; Elaine Del Nery; Thomas Weide; Tatiana Stepanova; Niels Galjart; Frank Grosveld; Bruno Goud; Chris I De Zeeuw; Angelika Barnekow; Casper C Hoogenraad
Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.
Nature cell biology 2002;4(12):986-92.
2002: Mehrnaz Ghazvini; Wim Mandemakers; Martine Jaegle; Marko Piirsoo; Siska Driegen; Manoussos Koutsourakis; Xsander Smit; Frank Grosveld; Dies Meijer
A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.
The EMBO journal 2002;21(17):4612-20.
2002: Casper C Hoogenraad; Bas Koekkoek; Anna Akhmanova; Harm J Krugers; Bjorn Dortland; Marja Miedema; Arjan van Alphen; Werner M Kistler; Martine Jaegle; Manoussos Koutsourakis; Nadja Van Camp; Marleen Verhoye; Annemie Van der Linden; Irina Kaverina; Frank Grosveld; Chris I De Zeeuw; Niels Galjart
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
Nature genetics 2002;32(1):116-27.
2002: Ton de Wit; Frank Grosveld; Dubravka Drabek
The tomato RNA-directed RNA polymerase has no effect on gene silencing by RNA interference in transgenic mice.
Transgenic research 2002;11(3):305-10.
2002: Mariken de Krom; Mariette van de Corput; Marieke von Lindern; Frank Grosveld; John Strouboulis
Stochastic patterns in globin gene expression are established prior to transcriptional activation and are clonally inherited.
Molecular cell 2002;9(6):1319-26.
2002: C-M Chow; Aglaia Athanassiadou; Selina Raguz; Lambrini Psiouri; Lee Harland; M Malik; M A Aitken; Frank Grosveld; Michael Antoniou
LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectors.
Gene therapy 2002;9(5):327-36.
2002: David Whyatt; Frank Grosveld
Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes.
EMBO reports 2002;3(2):130-5.
2001: Itamar Simon; T Tenzen; Raul Mostoslavsky; Eitan Fibach; L Lande; E Milot; J Gribnau; Frank Grosveld; P Fraser; Howard Cedar
Developmental regulation of DNA replication timing at the human beta globin locus.
The EMBO journal 2001;20(21):6150-7.
2001: Laskaro Zagoraiou; Dubravka Drabek; S Alexaki; J A Guy; Apostolos Klinakis; An Langeveld; G Skavdis; Clio Mamalaki; Frank Grosveld; Charalambos Savakis
In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11474-8.
2001: Maria Serafina Ristaldi; Dubravka Drabek; J Gribnau; Daniela Poddie; N Yannoutsous; Antonio Cao; Frank Grosveld; A M Ali Imam
The role of the -50 region of the human gamma-globin gene in switching.
The EMBO journal 2001;20(18):5242-9.
2001: Mariette van de Corput; Frank Grosveld
Fluorescence in situ hybridization analysis of transcript dynamics in cells.
Methods (San Diego, Calif.) 2001;25(1):111-8.
2001: H Göllner; Peter Bouwman; M Mangold; Alar Karis; Harald Braun; I Rohner; Adriana del Rey; Hugo O Besedovsky; A Meinhardt; M van den Broek; T Cutforth; Frank Grosveld; Sjaak Philipsen; Guntram Suske
Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(8):689-97.
2001: Casper C Hoogenraad; Anna Akhmanova; S A Howell; Bjorn Dortland; Chris I De Zeeuw; Rob Willemsen; Pim Visser; Frank Grosveld; Niels Galjart
Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.
The EMBO journal 2001;20(15):4041-54.
2001: MC Nawijn; Gemma M Dingjan; Rita Ferreira; Bart N Lambrecht; Alar Karis; Frank Grosveld; Huub F J Savelkoul; Rudolf W Hendriks
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):724-32.
2001: MC Nawijn; Rita Ferreira; Gemma M Dingjan; O Kahre; Dubravka Drabek; Alar Karis; Frank Grosveld; Rudolf W Hendriks
Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):715-23.
2001: Manoussos Koutsourakis; Richard Keijzer; Pim Visser; Martin Post; Dick Tibboel; Frank Grosveld
Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression.
Mechanisms of development 2001;105(1-2):105-14.
2001: Gemma M Dingjan; Sabine Middendorp; Katarina Dahlenborg; Alex Maas; Frank Grosveld; Rudolf W Hendriks
Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse.
The Journal of experimental medicine 2001;193(10):1169-78.
2001: Anna Akhmanova; Casper C Hoogenraad; Ksenija Drabek; Tatiana Stepanova; Bjorn Dortland; T Verkerk; Wim Vermeulen; Boudewijn M T Burgering; Chris I De Zeeuw; Frank Grosveld; Niels Galjart
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
Cell 2001;104(6):923-35.
2001: Richard Keijzer; Minke Van Tuyl; Carel Meijers; Martin Post; Dick Tibboel; Frank Grosveld; Manoussos Koutsourakis
The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development.
Development (Cambridge, England) 2001;128(4):503-11.
2001: Alar Karis; I Pata; J Hikke van Doorninck; Frank Grosveld; Chris I De Zeeuw; D de Caprona; B Fritzsch
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear.
The Journal of comparative neurology 2001;429(4):615-30.
2001: N D van Loo; E Fortunati; E Ehlert; M Rabelink; Frank Grosveld; Bob J Scholte
Baculovirus infection of nondividing mammalian cells: mechanisms of entry and nuclear transport of capsids.
Journal of virology 2001;75(2):961-70.
2000: Anna Akhmanova; T Verkerk; An Langeveld; Frank Grosveld; Niels Galjart
Characterisation of transcriptionally active and inactive chromatin domains in neurons.
Journal of cell science 2000;113 Pt 24():4463-74.
2000: Keiji Tanimoto; Q Liu; Frank Grosveld; Jörg Bungert; James Douglas Engel
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.
Genes & development 2000;14(21):2778-94.
2000: Gaetano Zafarana; Robbert Rottier; Frank Grosveld; Sjaak Philipsen
Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesis.
The EMBO journal 2000;19(21):5856-63.
2000: Tara McMorrow; A van den Wijngaard; A Wollenschlaeger; Mariette van de Corput; K Monkhorst; T Trimborn; P Fraser; Maarten van Lohuizen; T Jenuwein; Malek Djabali; Sjaak Philipsen; Frank Grosveld; E Milot
Activation of the beta globin locus by transcription factors and chromatin modifiers.
The EMBO journal 2000;19(18):4986-96.
2000: E Fortunati; E Ehlert; N D van Loo; C Wyman; J A Eble; Frank Grosveld; Bob J Scholte
A multi-domain protein for beta1 integrin-targeted DNA delivery.
Gene therapy 2000;7(17):1505-15.
2000: David Whyatt; Fokke Lindeboom; Alar Karis; Rita Ferreira; E Milot; Rudolf W Hendriks; M de Bruijn; An Langeveld; J Gribnau; Frank Grosveld; Sjaak Philipsen
An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.
Nature 2000;406(6795):519-24.
2000: M G van Dixhoorn; Sylvia Dekker; R W Janssen; Caroline A E Verbakel; Frank Grosveld
Human CD46 rather than CD55 is a key element in protection against complement activation in vitro.
Transplantation proceedings 2000;32(5):916-8.
2000: Caroline A E Verbakel; Fred Bonthuis; S E Eerhart; M van Dixhoorn; Frank Grosveld; Richard L Marquet; Jan N M Ijzermans
Relative roles of hCD46 and hCD55 in the regulation of hyperacute rejection.
Transplantation proceedings 2000;32(5):903-4.
2000: A M Ali Imam; George P Patrinos; Mariken de Krom; S Bottardi; R J Janssens; Eleni Z Katsantoni; A W Wai; D J Sherratt; Frank Grosveld
Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli.
Nucleic acids research 2000;28(12):E65.
2000: Wim Mandemakers; R Zwart; Martine Jaegle; Erik T Walbeehm; Pim Visser; Frank Grosveld; Dies Meijer
A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration.
The EMBO journal 2000;19(12):2992-3003.
2000: Kim-Chew Lim; G Lakshmanan; S E Crawford; Y Gu; Frank Grosveld; James Douglas Engel
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.
Nature genetics 2000;25(2):209-12.
2000: Casper C Hoogenraad; Anna Akhmanova; Frank Grosveld; C I De Zeeuw; Niels Galjart
Functional analysis of CLIP-115 and its binding to microtubules.
Journal of cell science 2000;113 ( Pt 12)():2285-97.
2000: Rien van Haperen; Arie Van Tol; P Vermeulen; Matti Jauhiainen; Teus van Gent; P van den Berg; Sonja Jaari; Frank Grosveld; Arthur van der Kamp; Rini de Crom
Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):1082-8.
2000: Peter Bouwman; H Göllner; Hans-Peter Elsässer; G Eckhoff; Alar Karis; Frank Grosveld; Sjaak Philipsen; Guntram Suske
Transcription factor Sp3 is essential for post-natal survival and late tooth development.
The EMBO journal 2000;19(4):655-61.
1999: I Pata; M Studer; J Hikke van Doorninck; J Briscoe; S Kuuse; James Douglas Engel; Frank Grosveld; Alar Karis
The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4.
Development (Cambridge, England) 1999;126(23):5523-31.
1999: J Hikke van Doorninck; Jacqueline van der Wees; Alar Karis; E Goedknegt; James Douglas Engel; Michiel Coesmans; Mandy Rutteman; Frank Grosveld; Chris I De Zeeuw
GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(12):RC12.
1999: Rudolf W Hendriks; MC Nawijn; James Douglas Engel; H van Doorninck; Frank Grosveld; Alar Karis
Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus.
European journal of immunology 1999;29(6):1912-8.
1999: Alex Maas; Gemma M Dingjan; Frank Grosveld; Rudolf W Hendriks
Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter region.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6526-33.
1999: Noélia Custódio; Maria Carmo-Fonseca; Finola Geraghty; H S Pereira; Frank Grosveld; Michael Antoniou
Inefficient processing impairs release of RNA from the site of transcription.
The EMBO journal 1999;18(10):2855-66.
1999: Manoussos Koutsourakis; An Langeveld; Roger Patient; R Beddington; Frank Grosveld
The transcription factor GATA6 is essential for early extraembryonic development.
Development (Cambridge, England) 1999;126(9):723-32.
1999: J Guy; R Willemsen; An Langeveld; Frank Grosveld; Dubravka Drabek
Murine MHC class II locus control region drives expression of human beta-glucocerebrosidase in antigen presenting cells of transgenic mice.
Gene therapy 1999;6(4):498-507.
1999: Frank Grosveld
Activation by locus control regions?
Current opinion in genetics & development 1999;9(2):152-7.
1999: Rini de Crom; Rien van Haperen; R Janssens; Pim Visser; Rob Willemsen; Frank Grosveld; Arthur van der Kamp
Gp96/GRP94 is a putative high density lipoprotein-binding protein in liver.
Biochimica et biophysica acta 1999;1437(3):378-92.
1999: R Calzolari; Tara McMorrow; N Yannoutsos; An Langeveld; Frank Grosveld
Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression.
The EMBO journal 1999;18(4):949-58.
1999: Manoussos Koutsourakis; An Langeveld; Roger Patient; R Beddington; Frank Grosveld
The transcription factor GATA6 is essential for early extraembryonic development.
Development (Cambridge, England) 1999;126(4):723-32.
1999: G Lakshmanan; Kenneth Lieuw; Kim-Chew Lim; Y Gu; Frank Grosveld; James Douglas Engel; Alar Karis
Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus.
Molecular and cellular biology 1999;19(2):1558-68.
1999: T Trimborn; J Gribnau; Frank Grosveld; P Fraser
Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci.
Genes & development 1999;13(1):112-24.
1998: G Lakshmanan; Kenneth Lieuw; Frank Grosveld; James Douglas Engel
Partial rescue of GATA-3 by yeast artificial chromosome transgenes.
Developmental biology 1998;204(2):451-63.
1998: Casper C Hoogenraad; Bert H J Eussen; An Langeveld; Rien van Haperen; S Winterberg; Cokkie H Wouters; Frank Grosveld; Chris I De Zeeuw; Niels Galjart
The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region.
Genomics 1998;53(3):348-58.
1998: J Gribnau; E de Boer; T Trimborn; M Wijgerde; E Milot; Frank Grosveld; P Fraser
Chromatin interaction mechanism of transcriptional control in vivo.
The EMBO journal 1998;17(20):6020-7.
1998: Nynke Gillemans; Rita Tewari; Fokke Lindeboom; Robbert Rottier; Ton de Wit; M Wijgerde; Frank Grosveld; Sjaak Philipsen
Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
Genes & development 1998;12(18):2863-73.
1998: Gemma M Dingjan; Alex Maas; MC Nawijn; L Smit; Jane S A Voerman; Frank Grosveld; Rudolf W Hendriks
Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase.
The EMBO journal 1998;17(18):5309-20.
1998: Frank Grosveld; E de Boer; Niall Dillon; J Gribnau; E Milot; T Trimborn; M Wijgerde; P Fraser
The dynamics of globin gene expression and gene therapy vectors.
Annals of the New York Academy of Sciences 1998;850():18-27.
1998: F Levavasseur; Wim Mandemakers; Pim Visser; Ludo Broos; Frank Grosveld; D Zivkovic; Dies Meijer
Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse.
Mechanisms of development 1998;74(1-2):89-98.
1998: P Fraser; Frank Grosveld
Locus control regions, chromatin activation and transcription.
Current opinion in cell biology 1998;10(3):361-5.
1998: Rita Tewari; Nynke Gillemans; M Wijgerde; B Nuez; Marieke von Lindern; Frank Grosveld; Sjaak Philipsen
Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.
The EMBO journal 1998;17(8):2334-41.
1998: E Payen; T Verkerk; D Michalovich; Sandra D Dreyer; Andreas Winterpacht; Brendan Lee; Chris I De Zeeuw; Frank Grosveld; Niels Galjart
The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains.
The Journal of biological chemistry 1998;273(15):9099-109.
1998: Frank Grosveld; E de Boer; Niall Dillon; P Fraser; J Gribnau; E Milot; T Trimborn; M Wijgerde
The dynamics of globin gene expression and gene therapy vectors.
Seminars in hematology 1998;35(2):105-11.
1998: D A Kleinjan; Sylvia Dekker; J A Guy; Frank Grosveld
Cloning and sequencing of the CRABP-I locus from chicken and pufferfish: analysis of the promoter regions in transgenic mice.
Transgenic research 1998;7(2):85-94.
1998: Michael Antoniou; Finola Geraghty; J Hurst; Frank Grosveld
Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction.
Nucleic acids research 1998;26(3):721-9.
1998: Ton de Wit; Dubravka Drabek; Frank Grosveld
Microinjection of cre recombinase RNA induces site-specific recombination of a transgene in mouse oocytes.
Nucleic acids research 1998;26(2):676-8.
1998: Frank Grosveld; E de Boer; Niall Dillon; J Gribnau; Tara McMorrow; E Milot; T Trimborn; M Wijgerde; P Fraser
The dynamics of globin gene expression and position effects.
Novartis Foundation symposium 1998;214():67-79; discussion 79-86.
1997: Niall Dillon; T Trimborn; J Strouboulis; P Fraser; Frank Grosveld
The effect of distance on long-range chromatin interactions.
Molecular cell 1997;1(1):131-9.
1997: Chris I De Zeeuw; Casper C Hoogenraad; E Goedknegt; E Hertzberg; A Neubauer; Frank Grosveld; Niels Galjart
CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies.
Neuron 1997;19(6):1187-99.
1997: D A Kleinjan; Sylvia Dekker; M J Vaessen; Frank Grosveld
Regulation of the CRABP-I gene during mouse embryogenesis.
Mechanisms of development 1997;67(2):157-69.
1997: Alex Maas; Gemma M Dingjan; Huub F J Savelkoul; C Kinnon; Frank Grosveld; Rudolf W Hendriks
The X-linked immunodeficiency defect in the mouse is corrected by expression of human Bruton's tyrosine kinase from a yeast artificial chromosome transgene.
European journal of immunology 1997;27(9):2180-7.
1997: Kenneth Lieuw; G l Li; Yinghui Zhou; Frank Grosveld; James Douglas Engel
Temporal and spatial control of murine GATA-3 transcription by promoter-proximal regulatory elements.
Developmental biology 1997;188(1):1-16.
1997: S K E Koekkoek; A M v Alphen; J vd Burg; Frank Grosveld; Niels Galjart; Chris I De Zeeuw
Gain adaptation and phase dynamics of compensatory eye movements in mice.
Genes and function 1997;1(3):175-90.
1997: M Marin; Alar Karis; P Visser; Frank Grosveld; Sjaak Philipsen
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.
Cell 1997;89(4):619-28.
1997: David Whyatt; Alar Karis; I C Harkes; A Verkerk; Nynke Gillemans; Andrew G Elefanty; G Vairo; Rob E Ploemacher; Frank Grosveld; Sjaak Philipsen
The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery.
Genes and function 1997;1(1):11-24.
1997: Dubravka Drabek; J Guy; R Craig; Frank Grosveld
The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.
Gene therapy 1997;4(2):93-100.
1997: L G Wilming; C A Snoeren; A van Rijswijk; Frank Grosveld; Carel Meijers
The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.
Human molecular genetics 1997;6(2):247-58.
1997: GT Ma; M E Roth; J C Groskopf; F Y Tsai; Stuart H Orkin; Frank Grosveld; James Douglas Engel; Daniel I H Linzer
GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
Development (Cambridge, England) 1997;124(4):907-14.
1997: Dubravka Drabek; S Raguz; Ton de Wit; Gemma M Dingjan; Huub F J Savelkoul; Frank Grosveld; Rudolf W Hendriks
Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):610-5.
1996: R Tewari; Nynke Gillemans; A Harper; M Wijgerde; G Zafarana; Dubravka Drabek; Frank Grosveld; Sjaak Philipsen
The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene.
Development (Cambridge, England) 1996;122(12):3991-9.
1996: M Wijgerde; J Gribnau; T Trimborn; B Nuez; Sjaak Philipsen; Frank Grosveld; P Fraser
The role of EKLF in human beta-globin gene competition.
Genes & development 1996;10(22):2894-902.
1996: E Milot; J Strouboulis; T Trimborn; M Wijgerde; E de Boer; An Langeveld; K Tan-Un; W Vergeer; N Yannoutsos; Frank Grosveld; P Fraser
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.
Cell 1996;87(1):105-14.
1996: Rudolf W Hendriks; M F de Bruijn; Alex Maas; Gemma M Dingjan; Alar Karis; Frank Grosveld
Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.
The EMBO journal 1996;15(18):4862-72.
1996: M Jaegle; Wim Mandemakers; L Broos; R Zwart; Alar Karis; Pim Visser; Frank Grosveld; Dies Meijer
The POU factor Oct-6 and Schwann cell differentiation.
Science (New York, N.Y.) 1996;273(5274):507-10.
1996: N Mazarakis; D Michalovich; Alar Karis; Frank Grosveld; Niels Galjart
Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS.
Genomics 1996;33(2):247-57.
1996: N Yannoutsos; Jan N M Ijzermans; C Harkes; Fred Bonthuis; C Y Zhou; D White; Richard L Marquet; Frank Grosveld
A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(4):409-19.
1996: E Milot; P Fraser; Frank Grosveld
Position effects and genetic disease.
Trends in genetics : TIG 1996;12(4):123-6.
1996: James Ellis; K C Tan-Un; A Harper; D Michalovich; N Yannoutsos; Sjaak Philipsen; Frank Grosveld
A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.
The EMBO journal 1996;15(3):562-8.
1996: A G Elefanty; Michael Antoniou; N Custodio; Maria Carmo-Fonseca; Frank Grosveld
GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.
The EMBO journal 1996;15(2):319-33.
1996: A Ronchi; M Berry; S Raguz; A Imam; N Yannoutsos; S Ottolenghi; Frank Grosveld; Niall Dillon
Role of the duplicated CCAAT box region in gamma-globin gene regulation and hereditary persistence of fetal haemoglobin.
The EMBO journal 1996;15(1):143-9.
1996: N D Mazarakis; N Yannoutsos; J N el-Jabbour; W Hatton; R Fletcher; Frank Grosveld
Neurocristopathy resembling neurofibromatosis type 1 in an NGF-SV40 transgenic line.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(1):125-37.
1995: X Y Zhou; Hans Morreau; Robbert Rottier; D Davis; Erik J Bonten; Nynke Gillemans; D Wenger; Frank Grosveld; Peter C Doherty; K Suzuki; G C Grosveld; A d'Azzo
Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells.
Genes & development 1995;9(21):2623-34.
1995: M Wijgerde; Frank Grosveld; P Fraser
Transcription complex stability and chromatin dynamics in vivo.
Nature 1995;377(6546):209-13.
1995: Michael Antoniou; E de Boer; E Spanopoulou; A Imam; Frank Grosveld
TBP binding and the rate of transcription initiation from the human beta-globin gene.
Nucleic acids research 1995;23(17):3473-80.
1995: Pier Paolo Pandolfi; M E Roth; A Karis; M W Leonard; E Dzierzak; Frank Grosveld; James Douglas Engel; M H Lindenbaum
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
Nature genetics 1995;11(1):40-4.
1995: B Nuez; D Michalovich; Anne Elisabeth Bygrave; Rob E Ploemacher; Frank Grosveld
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene.
Nature 1995;375(6529):316-8.
1994: S Pruzina; Michael Antoniou; J Hurst; Frank Grosveld; Sjaak Philipsen
Transcriptional activation by hypersensitive site three of the human beta-globin locus control region in murine erythroleukemia cells.
Biochimica et biophysica acta 1994;1219(2):351-60.
1994: K M George; M W Leonard; M E Roth; Kenneth Lieuw; D Kioussis; Frank Grosveld; James Douglas Engel
Embryonic expression and cloning of the murine GATA-3 gene.
Development (Cambridge, England) 1994;120(9):2673-86.
1994: K P Foley; S Pruzina; J D Winick; James Douglas Engel; Frank Grosveld; P Fraser
The chicken beta/epsilon-globin enhancer directs autonomously regulated, high-level expression of the chicken epsilon-globin gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7252-6.
1994: M C Tiveron; M Nosten-Bertrand; H Jani; D Garnett; E M Hirst; Frank Grosveld; R J Morris
The mode of anchorage to the cell surface determines both the function and the membrane location of Thy-1 glycoprotein.
Journal of cell science 1994;107 ( Pt 7)():1783-96.
1994: A M Müller; Alexander L Medvinsky; J Strouboulis; Frank Grosveld; Elaine Dzierzak
Development of hematopoietic stem cell activity in the mouse embryo.
Immunity 1994;1(4):291-301.
1994: Niall Dillon; Frank Grosveld
Chromatin domains as potential units of eukaryotic gene function.
Current opinion in genetics & development 1994;4(2):260-4.
1993: D J Whyatt; E deBoer; Frank Grosveld
The two zinc finger-like domains of GATA-1 have different DNA binding specificities.
The EMBO journal 1993;12(13):4993-5005.
1993: J Wijnholds; Sjaak Philipsen; S Pruzina; P Fraser; Frank Grosveld; G Ab
Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice.
Nucleic acids research 1993;21(7):1629-35.
1993: Niall Dillon; Frank Grosveld
Transcriptional regulation of multigene loci: multilevel control.
Trends in genetics : TIG 1993;9(4):134-7.
1993: Sjaak Philipsen; S Pruzina; Frank Grosveld
The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.
The EMBO journal 1993;12(3):1077-85.
1993: Frank Grosveld; Niall Dillon; D Higgs
The regulation of human globin gene expression.
Baillière's clinical haematology 1993;6(1):31-55.
1993: Frank Grosveld; Michael Antoniou; M Berry; E de Boer; Niall Dillon; J Ellis; P Fraser; O Hanscombe; J Hurst; A Imam
The regulation of human globin gene switching.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;339(1288):183-91.
1993: K Yazdanbakhsh; P Fraser; Dimitris Kioussis; M Vidal; Frank Grosveld; M Lindenbaum
Functional analysis of the human neurofilament light chain gene promoter.
Nucleic acids research 1993;21(3):455-61.
1993: J Ellis; D Talbot; Niall Dillon; Frank Grosveld
Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.
The EMBO journal 1993;12(1):127-34.
1993: P Fraser; S Pruzina; Michael Antoniou; Frank Grosveld
Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.
Genes & development 1993;7(1):106-13.
1993: Frank Grosveld; Michael Antoniou; M Berry; E de Boer; Niall Dillon; J Ellis; P Fraser; J Hurst; A Imam; D Meijer
Regulation of human globin gene switching.
Cold Spring Harbor symposia on quantitative biology 1993;58():7-13.
1992: J Strouboulis; Niall Dillon; Frank Grosveld
Efficient joining of large DNA fragments for transgenesis.
Nucleic acids research 1992;20(22):6109-10.
1992: J Strouboulis; Niall Dillon; Frank Grosveld
Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.
Genes & development 1992;6(10):1857-64.
1992: M Berry; Frank Grosveld; Niall Dillon
A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin.
Nature 1992;358(6386):499-502.
1992: M C Tiveron; Erminia Barboni; F B Pliego Rivero; A M Gormley; P J Seeley; Frank Grosveld; R Morris
Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein.
Nature 1992;355(6362):745-8.
1991: O Hanscombe; D Whyatt; P Fraser; N Yannoutsos; D Greaves; Niall Dillon; Frank Grosveld
Importance of globin gene order for correct developmental expression.
Genes & development 1991;5(8):1387-94.
1991: D Talbot; Frank Grosveld
The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.
The EMBO journal 1991;10(6):1391-8.
1991: S Pruzina; O Hanscombe; D Whyatt; Frank Grosveld; Sjaak Philipsen
Hypersensitive site 4 of the human beta globin locus control region.
Nucleic acids research 1991;19(7):1413-9.
1991: E Spanopoulou; V Giguere; Frank Grosveld
The functional domains of the murine Thy-1 gene promoter.
Molecular and cellular biology 1991;11(4):2216-28.
1991: Niall Dillon; Frank Grosveld
Human gamma-globin genes silenced independently of other genes in the beta-globin locus.
Nature 1991;350(6315):252-4.
1990: M H Lindenbaum; Frank Grosveld
An in vitro globin gene switching model based on differentiated embryonic stem cells.
Genes & development 1990;4(12A):2075-85.
1990: D Talbot; Sjaak Philipsen; P Fraser; Frank Grosveld
Detailed analysis of the site 3 region of the human beta-globin dominant control region.
The EMBO journal 1990;9(7):2169-77.
1990: Sjaak Philipsen; D Talbot; P Fraser; Frank Grosveld
The beta-globin dominant control region: hypersensitive site 2.
The EMBO journal 1990;9(7):2159-67.
1990: P Fraser; J Hurst; P Collis; Frank Grosveld
DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.
Nucleic acids research 1990;18(12):3503-8.
1990: Michael Antoniou; Frank Grosveld
beta-globin dominant control region interacts differently with distal and proximal promoter elements.
Genes & development 1990;4(6):1007-13.
1990: M Vidal; C Wrighton; S Eccles; J Burke; Frank Grosveld
Differences in human cell lines to support stable replication of Epstein-Barr virus-based vectors.
Biochimica et biophysica acta 1990;1048(2-3):171-7.
1990: M Vidal; R Morris; Frank Grosveld; E Spanopoulou
Tissue-specific control elements of the Thy-1 gene.
The EMBO journal 1990;9(3):833-40.
1990: David Greaves; P Fraser; M A Vidal; M J Hedges; D Ropers; L Luzzatto; Frank Grosveld
A transgenic mouse model of sickle cell disorder.
Nature 1990;343(6254):183-5.
1990: P Collis; Michael Antoniou; Frank Grosveld
Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.
The EMBO journal 1990;9(1):233-40.
1990: Frank Grosveld; D Greaves; Sjaak Philipsen; D Talbot; S Pruzina; E deBoer; O Hanscombe; P Belhumeur; J Hurst; P Fraser
The dominant control region of the human beta-globin domain.
Annals of the New York Academy of Sciences 1990;612():152-9.
1989: E Spanopoulou; A Early; J Elliott; N Crispe; H Ladyman; M Ritter; S Watt; Frank Grosveld; Dimitris Kioussis
Complex lymphoid and epithelial thymic tumours in Thy1-myc transgenic mice.
Nature 1989;342(6246):185-9.
1989: O Hanscombe; M Vidal; J Kaeda; L Luzzatto; David Greaves; Frank Grosveld
High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.
Genes & development 1989;3(10):1572-81.
1989: F Catala; E deBoer; Gaston Habets; Frank Grosveld
Nuclear protein factors and erythroid transcription of the human A gamma-globin gene.
Nucleic acids research 1989;17(10):3811-27.
1989: G Blom van Assendelft; O Hanscombe; Frank Grosveld; David Greaves
The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner.
Cell 1989;56(6):969-77.
1989: D Talbot; P Collis; Michael Antoniou; M Vidal; Frank Grosveld; David Greaves
A dominant control region from the human beta-globin locus conferring integration site-independent gene expression.
Nature 1989;338(6213):352-5.
1989: V Mignotte; L Wall; E deBoer; Frank Grosveld; P H Romeo
Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene.
Nucleic acids research 1989;17(1):37-54.
1989: D R Greaves; Michael Antoniou; G B van Assendelft; P Collis; Niall Dillon; O Hanscombe; J Hurst; M Lindenbaum; D Talbot; Frank Grosveld
The beta-globin dominant control region.
Progress in clinical and biological research 1989;316A():37-46.
1989: L Wall; F Catala; Michael Antoniou; E deBoer; Frank Grosveld
The regulation of the human gamma- and beta -globin domain.
Progress in clinical and biological research 1989;316A():1-13.
1989: P H Romeo; V Mignotte; N Raich; Anne Dubart; D Beaupain; M Romana; C Chabret; L Wall; E deBoer; Frank Grosveld
Regulated expression of the erythroid-specific-promoter of the human PBG-D gene during erythroid differentiation.
Progress in clinical and biological research 1989;316A():359-66.
1989: R Morris; Frank Grosveld
Expression of Thy-1 in the nervous system of the rat and mouse.
Immunology series 1989;45():121-48.
1988: E deBoer; Michael Antoniou; V Mignotte; L Wall; Frank Grosveld
The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.
The EMBO journal 1988;7(13):4203-12.
1988: Jean-Pierre Julien; F Côté; L Beaudet; M Sidky; D Flavell; Frank Grosveld; Walter E Mushynski
Sequence and structure of the mouse gene coding for the largest neurofilament subunit.
Gene 1988;68(2):307-14.
1988: E Spanopoulou; V Giguere; Frank Grosveld
Transcriptional unit of the murine Thy-1 gene: different distribution of transcription initiation sites in brain.
Molecular and cellular biology 1988;8(9):3847-56.
1988: L Wall; E deBoer; Frank Grosveld
The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.
Genes & development 1988;2(9):1089-100.
1988: Michael Antoniou; E deBoer; Gaston Habets; Frank Grosveld
The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.
The EMBO journal 1988;7(2):377-84.
1988: N Wrighton; Frank Grosveld
A novel in vivo transcription assay demonstrates the presence of globin-inducing trans-acting factors in uninduced murine erythroleukemia cells.
Molecular and cellular biology 1988;8(1):130-7.
1987: Frank Grosveld; G B van Assendelft; David Greaves; G Kollias
Position-independent, high-level expression of the human beta-globin gene in transgenic mice.
Cell 1987;51(6):975-85.
1987: G Kollias; D J Evans; M Ritter; J Beech; R Morris; Frank Grosveld
Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities.
Cell 1987;51(1):21-31.
1987: E J Murray; Frank Grosveld
Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression.
The EMBO journal 1987;6(8):2329-35.
1987: G Kollias; J Hurst; E deBoer; Frank Grosveld
The human beta-globin gene contains a downstream developmental specific enhancer.
Nucleic acids research 1987;15(14):5739-47.
1987: Jean-Pierre Julien; Frank Grosveld; K Yazdanbaksh; D Flavell; D Meijer; Walter E Mushynski
The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family.
Biochimica et biophysica acta 1987;909(1):10-20.
1987: Frank Grosveld; Michael Antoniou; G B van Assendelft; E de Boer; J Hurst; G Kollias; F MacFarlane; N Wrighton
The regulation of expression of human beta-globin genes.
Progress in clinical and biological research 1987;251():133-44.
1987: J Hurst; D Flavell; Jean-Pierre Julien; D Meijer; Walter E Mushynski; Frank Grosveld
The human neurofilament gene (NEFL) is located on the short arm of chromosome 8.
Cytogenetics and cell genetics 1987;45(1):30-2.
1986: Jean-Pierre Julien; D Meyer; D Flavell; J Hurst; Frank Grosveld
Cloning and developmental expression of the murine neurofilament gene family.
Brain research 1986;387(3):243-50.
1986: Khashayarsha Khazaie; Fotini Gounari; Michael Antoniou; E deBoer; Frank Grosveld
Beta-globin gene promoter generates 5' truncated transcripts in the embryonic/fetal erythroid environment.
Nucleic acids research 1986;14(18):7199-212.
1986: R Taramelli; D Kioussis; E Vanin; K Bartram; J Groffen; J Hurst; Frank Grosveld
Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster.
Nucleic acids research 1986;14(17):7017-29.
1986: G Kollias; N Wrighton; J Hurst; Frank Grosveld
Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns.
Cell 1986;46(1):89-94.
1985: D Kioussis; F Wilson; Khashayarsha Khazaie; Frank Grosveld
Differential expression of human globin genes introduced in K562 cells.
The EMBO journal 1985;4(4):927-31.
1983: D Kioussis; E Vanin; T deLange; R A Flavell; Frank Grosveld
Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia.
Nature 1983;306(5944):662-6.
1983: E F Vanin; P S Henthorn; D Kioussis; Frank Grosveld; Oliver Smithies
Unexpected relationships between four large deletions in the human beta-globin gene cluster.
Cell 1983;35(3 Pt 2):701-9.
1983: Eric R Fearon; Haig Kazazian ; P G Waber; J I Lee; S E Antonarakis; Stuart H Orkin; E F Vanin; P S Henthorn; Frank Grosveld; Alan F Scott; G R Buchanan
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia.
Blood 1983;61(6):1269-74.