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Gerard Grosveld

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Ayten Kandilci; Geoffrey Neale; Jacqueline Surtel; Sabrina Terranova; Laura Janke; Gerard C Grosveld
Mapping of MN1 Sequences Necessary for Myeloid Transformation.
Amy D Marshall; Martijn A van der Ent; Gerard C Grosveld
PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.
Amy D Marshall; Gerard C Grosveld
Alveolar rhabdomyosarcoma - The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis.

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All Publications

2013: Ayten Kandilci; Geoffrey Neale; Jacqueline Surtel; Sabrina Terranova; Laura Janke; Gerard C Grosveld
Mapping of MN1 Sequences Necessary for Myeloid Transformation.
PloS one 2013;8(4):e61706.
2012: Amy D Marshall; Martijn A van der Ent; Gerard C Grosveld
PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.
Molecular carcinogenesis 2012;51(10):807-15.
2012: Amy D Marshall; Gerard C Grosveld
Alveolar rhabdomyosarcoma - The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis.
Skeletal muscle 2012;2(1):25.
2012: W Martijn ter Haar; Karel H M van Wely; Jacqueline Bonten; Bart Geverts; Gerard C Grosveld; Adriaan B Houtsmuller; Marjolein J F W Janssen; Magda A Meester-Smoor; Claudia C M M Schot; Ellen C Zwarthoff
The leukemia-associated fusion protein MN1-TEL blocks TEL-specific recognition sequences.
PloS one 2012;7(9):e46085.
2011: Fabrizio Picchione; Colin Pritchard; Irina Lagutina; Laura Janke; Gerard C Grosveld
IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS).
Carcinogenesis 2011;32(4):452-61.
2009: Ayten Kandilci; Gerard C Grosveld
Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.
Blood 2009;114(8):1596-606.
2008: Magda A Meester-Smoor; Marjolein J F W Janssen; Gerard C Grosveld; Annelies de Klein; Wilfred F J van Ijcken; Hannie Douben; Ellen C Zwarthoff
MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression.
Carcinogenesis 2008;29(10):2025-34.
2007: Hiroyuki Kawagoe; Ayten Kandilci; Tanya A Kranenburg; Gerard C Grosveld
Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice.
Cancer research 2007;67(22):10677-85.
2007: Gerard C Grosveld
MN1, a novel player in human AML.
Blood cells, molecules & diseases 2007;39(3):336-9.
2007: Karel H M van Wely; Magda A Meester-Smoor; M J F W Janssen; A-J Aarnoudse; Gerard C Grosveld; Ellen C Zwarthoff
The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription.
Oncogene 2007;26(39):5733-40.
2007: Ugur Ozbek; Ayten Kandilci; Sjozef van Baal; Jacqueline Bonten; Kelli Boyd; Patrick Franken; Riccardo Fodde; Gerard C Grosveld
SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice.
The American journal of pathology 2007;171(2):654-66.
2007: cintia carella; Jacqueline Bonten; Sema Sirma; T A Kranenburg; S Terranova; R Klein-Geltink; Sheila A Shurtleff; James R Downing; Ellen C Zwarthoff; P P Liu; Gerard C Grosveld
MN1 overexpression is an important step in the development of inv(16) AML.
Leukemia 2007;21(8):1679-90.
2007: Christine Hartford; Erick Vasquez; Matthias Schwab; Mathew J Edick; Jerold E Rehg; Gerard C Grosveld; Ching-Hon Pui; William Evans; Mary Relling
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.
Cancer research 2007;67(10):4965-72.
2007: Magda A Meester-Smoor; Anco C Molijn; Yixian Zhao; Nicole A Groen; Cora A H Groffen; Merel Boogaard; Diny van Dalsum-Verbiest; Gerard C Grosveld; Ellen C Zwarthoff
The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence.
Journal of molecular endocrinology 2007;38(1-2):113-25.
2006: Morgan Sammons; Shan Shan Wan; Nancy L Vogel; Edwin J Mientjes; Gerard C Grosveld; Brian P Ashburner
Negative regulation of the RelA/p65 transactivation function by the product of the DEK proto-oncogene.
The Journal of biological chemistry 2006;281(37):26802-12.
2006: cintia carella; Jacqueline Bonten; Jerold E Rehg; Gerard C Grosveld
MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice.
Leukemia 2006;20(9):1582-92.
2006: cintia carella; Mark Potter; Jacqueline Bonten; Jerold E Rehg; Geoffrey A M Neale; Gerard C Grosveld
The ETS factor TEL2 is a hematopoietic oncoprotein.
Blood 2006;107(3):1124-32.
2005: Hiroyuki Kawagoe; Gerard C Grosveld
Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9.
Blood 2005;106(13):4269-77.
2005: Hiroyuki Kawagoe; Gerard C Grosveld
MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice.
Blood 2005;106(13):4278-86.
2005: Philippe R J Bois; Kamel Izeradjene; Peter J Houghton; John L Cleveland; Janet A Houghton; Gerard C Grosveld
FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.
The Journal of cell biology 2005;170(6):903-12.
2005: Philippe R J Bois; Vanessa F Brochard; Adèle V A Salin-Cantegrel; John L Cleveland; Gerard C Grosveld
FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion.
Molecular and cellular biology 2005;25(17):7645-56.
2005: Ayten Kandilci; Gerard C Grosveld
SET-induced calcium signaling and MAPK/ERK pathway activation mediate dendritic cell-like differentiation of U937 cells.
Leukemia 2005;19(8):1439-45.
2005: Monica Cardone; Ayten Kandilci; cintia carella; Jonas A Nilsson; Jennifer A Brennan; Sema Sirma; Ugur Ozbek; Kelli Boyd; John L Cleveland; Gerard C Grosveld
The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.
Molecular and cellular biology 2005;25(6):2395-405.
2004: Hiroyuki Kawagoe; Mark Potter; John Ellis; Gerard C Grosveld
TEL2, an ETS factor expressed in human leukemia, regulates monocytic differentiation of U937 Cells and blocks the inhibitory effect of TEL1 on ras-induced cellular transformation.
Cancer research 2004;64(17):6091-100.
2004: Licia Selleri; Jorge F DiMartino; Jan M A van Deursen; Andrea Brendolan; Mrinmoy Sanyal; Elles Boon; Terence D Capellini; Kevin S Smith; Joon Rhee; Heike Pöpperl; Gerard C Grosveld; Michael L Cleary
The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.
Molecular and cellular biology 2004;24(12):5324-31.
2004: Ayten Kandilci; Edwin J Mientjes; Gerard C Grosveld
Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937.
Leukemia 2004;18(2):337-40.
2003: Philippe R J Bois; Gerard C Grosveld
FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts.
The EMBO journal 2003;22(5):1147-57.
2003: Colin Pritchard; Gerard C Grosveld; Andrew D Hollenbach
Alternative splicing of Pax3 produces a transcriptionally inactive protein.
Gene 2003;305(1):61-9.
2003: Karel H M van Wely; Anco C Molijn; Arjan Buijs; Magda A Meester-Smoor; Albert Jan Aarnoudse; Anita J C G M Hellemons; Pim den Besten; Gerard C Grosveld; Ellen C Zwarthoff
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription.
Oncogene 2003;22(5):699-709.
2002: Irina Lagutina; Simon J Conway; Jack Sublett; Gerard C Grosveld
Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.
Molecular and cellular biology 2002;22(20):7204-16.
2002: Andrew D Hollenbach; Craig J McPherson; Edwin J Mientjes; Rekha Iyengar; Gerard C Grosveld
Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
Journal of cell science 2002;115(Pt 16):3319-30.
2002: Andrew D Hollenbach; Craig J McPherson; Irina Lagutina; Gerard C Grosveld
The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3.
Biochimica et biophysica acta 2002;1574(3):321-8.
2002: Jeffrey T Wigle; Natasha Harvey; Michael Detmar; Irina Lagutina; Gerard C Grosveld; Michael D Gunn; David G Jackson; Guillermo Oliver
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.
The EMBO journal 2002;21(7):1505-13.
2002: L van Rompaey; Eric C Holland; Gerard C Grosveld
TEL Induces Aggregation in Transformed Cells and Induces Tube Formation in NIH3T3-UCLA Cells.
Biochemical and biophysical research communications 2002;291(4):820-8.
2001: S Zhou; John D Schuetz; Kevin D Bunting; A M Colapietro; Janardhan Sampath; J J Morris; Irina Lagutina; Gerard C Grosveld; M Osawa; H Nakauchi; Brian P Sorrentino
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.
Nature medicine 2001;7(9):1028-34.
2000: Arjan Buijs; L van Rompaey; Anco C Molijn; James Davis; A C Vertegaal; M D Potter; C Adams; Sjozef van Baal; Ellen C Zwarthoff; Martine F Roussel; Gerard C Grosveld
The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.
Molecular and cellular biology 2000;20(24):9281-93.
2000: L V Rompaey; M Potter; C Adams; Gerard C Grosveld
Tel induces a G1 arrest and suppresses Ras-induced transformation.
Oncogene 2000;19(46):5244-50.
2000: T McGarvey; Emanuel Rosonina; Susan McCracken; Q Li; R Arnaout; Edwin J Mientjes; Jeffrey A Nickerson; Donald E Awrey; Jack Greenblatt; Gerard C Grosveld; Benjamin J Blencowe
The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes.
The Journal of cell biology 2000;150(2):309-20.
2000: M D Potter; Arjan Buijs; B Kreider; L van Rompaey; Gerard C Grosveld
Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6.
Blood 2000;95(11):3341-8.
2000: Frederique Zindy; Jan M A van Deursen; Gerard C Grosveld; Charles J Sherr; Martine F Roussel
INK4d-deficient mice are fertile despite testicular atrophy.
Molecular and cellular biology 2000;20(1):372-8.
1999: L van Rompaey; W Dou; Arjan Buijs; Gerard C Grosveld
Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components.
Neoplasia (New York, N.Y.) 1999;1(6):526-36.
1999: Andrew D Hollenbach; J E Sublett; Craig J McPherson; Gerard C Grosveld
The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx.
The EMBO journal 1999;18(13):3702-11.
1999: Richard Moriggl; David J Topham; S Teglund; Veronika Sexl; Catriona McKay; Denan Wang; Angelika Hoffmeyer; Jan M A van Deursen; Mark Y Sangster; Kevin D Bunting; Gerard C Grosveld; James N Ihle
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Immunity 1999;10(2):249-59.
1998: S Teglund; Catriona McKay; E Schuetz; Jan M A van Deursen; D Stravopodis; Denan Wang; M Brown; S Bodner; Gerard C Grosveld; James N Ihle
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.
Cell 1998;93(5):841-50.
1998: Evan Parganas; Denan Wang; D Stravopodis; David J Topham; Jean-Christophe Marine; S Teglund; E F Vanin; S Bodner; Oscar R Colamonici; Jan M A van Deursen; Gerard C Grosveld; James N Ihle
Jak2 is essential for signaling through a variety of cytokine receptors.
Cell 1998;93(3):385-95.
1998: JM Boer; J Bonten-Surtel; Gerard C Grosveld
Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis.
Molecular and cellular biology 1998;18(3):1236-47.
1997: Susana C Raimondi; Sheila A Shurtleff; James R Downing; Jeffrey E Rubnitz; S Mathew; M Hancock; Ching-Hon Pui; Jaime Rivera; Gerard C Grosveld; Frederick G. Behm
12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia.
Blood 1997;90(11):4559-66.
1997: T Kamijo; Frederique Zindy; Martine F Roussel; Dawn E Quelle; James R Downing; RA Ashmun; Gerard C Grosveld; Charles J Sherr
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.
Cell 1997;91(5):649-59.
1997: Maarten Fornerod; Sjozef van Baal; V Valentine; D N Shapiro; Gerard C Grosveld
Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32.
Genomics 1997;42(3):538-40.
1997: JM Boer; Jan M A van Deursen; Huib Croes; Jack Fransen; Gerard C Grosveld
The nucleoporin CAN/Nup214 binds to both the cytoplasmic and the nucleoplasmic sides of the nuclear pore complex in overexpressing cells.
Experimental cell research 1997;232(1):182-5.
1997: Jeffrey E Rubnitz; James R Downing; Ching-Hon Pui; Sheila A Shurtleff; Susana C Raimondi; William Evans; DR Head; William M Crist; Jaime Rivera; Michael L Hancock; James M Boyett; Arjan Buijs; Gerard C Grosveld; Frederick G. Behm
TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(3):1150-7.
1997: Maarten Fornerod; Jan M A van Deursen; Sjozef van Baal; A Reynolds; D Davis; K G Murti; J Fransen; Gerard C Grosveld
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.
The EMBO journal 1997;16(4):807-16.
1997: JM Boer; Hazem H Mahmoud; S Raimondi; Gerard C Grosveld; Robert A Krance
Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukemia following chemotherapy and allogeneic bone marrow transplantation.
Leukemia 1997;11(2):299-300.
1996: Erik J Bonten; A van der Spoel; Maarten Fornerod; Gerard C Grosveld; Alessandra d'Azzo
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
Genes & development 1996;10(24):3156-69.
1996: Maarten Fornerod; J Boer; Sjozef van Baal; Hans Morreau; Gerard C Grosveld
Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN.
Oncogene 1996;13(8):1801-8.
1996: Jan M A van Deursen; J Boer; Lawryn H Kasper; Gerard C Grosveld
G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214.
The EMBO journal 1996;15(20):5574-83.
1996: William E Thierfelder; Jan M A van Deursen; K Yamamoto; Ralph A Tripp; S R Sarawar; RT Carson; Mark Y Sangster; Dario A A Vignali; Peter C Doherty; Gerard C Grosveld; James N Ihle
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.
Nature 1996;382(6587):171-4.
1996: K Shimoda; Jan M A van Deursen; Mark Y Sangster; S R Sarawar; RT Carson; Ralph A Tripp; C Chu; F W Quelle; T Nosaka; Dario A A Vignali; Peter C Doherty; Gerard C Grosveld; William Paul; James N Ihle
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Nature 1996;380(6575):630-3.
1996: Scott W Hiebert; W Sun; James Davis; Todd R Golub; Sheila A Shurtleff; Arjan Buijs; James R Downing; Gerard C Grosveld; M F Roussell; D Gary Gilliland; Noel Lenny; S Meyers
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.
Molecular and cellular biology 1996;16(4):1349-55.
1996: R Zwart; L Broos; Gerard C Grosveld; Dies Meijer
The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system.
Mechanisms of development 1996;54(2):185-94.
1996: T Okuda; Jan M A van Deursen; S W Hiebert; Gerard C Grosveld; James R Downing
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
Cell 1996;84(2):321-30.
1995: Sheila A Shurtleff; Arjan Buijs; Frederick G. Behm; Jeffrey E Rubnitz; Susana C Raimondi; Michael L Hancock; G C Chan; Ching-Hon Pui; Gerard C Grosveld; James R Downing
TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.
Leukemia 1995;9(12):1985-9.
1995: T Nosaka; Jan M A van Deursen; Ralph A Tripp; William E Thierfelder; bruce witthuhn; A P McMickle; Peter C Doherty; Gerard C Grosveld; James N Ihle
Defective lymphoid development in mice lacking Jak3.
Science (New York, N.Y.) 1995;270(5237):800-2.
1995: Y Yang; E F Vanin; M A Whitt; Maarten Fornerod; R Zwart; R D Schneiderman; Gerard C Grosveld; A W Nienhuis
Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis virus G envelope protein.
Human gene therapy 1995;6(9):1203-13.
1995: Jan M A van Deursen; Maarten Fornerod; B Van Rees; Gerard C Grosveld
Cre-mediated site-specific translocation between nonhomologous mouse chromosomes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7376-80.
1995: Maarten Fornerod; J Boer; Sjozef van Baal; M Jaeglé; Marieke von Lindern; K G Murti; D Davis; J Bonten; Arjan Buijs; Gerard C Grosveld
Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.
Oncogene 1995;10(9):1739-48.
1994: J van Denderen; P ten Hacken; P Berendes; N Zegers; W Boersma; Gerard C Grosveld; Willem van Ewijk
Recognition of the ALL-specific BCR-ABL junction in P190bcr-abl by monoclonal antibody ER-FP1.
Leukemia 1994;8(9):1503-9.
1993: Anne Hagemeijer; Arjan Buijs; E Smit; Bart Janssen; G J Creemers; D Van der Plas; Gerard C Grosveld
Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia.
Genes, chromosomes & cancer 1993;8(4):237-45.
1992: J van Denderen; P ten Hacken; P Berendes; N Zegers; W Boersma; Gerard C Grosveld; Willem van Ewijk
Antibody recognition of the tumor-specific b3-a2 junction of bcr-abl chimeric proteins in Philadelphia-chromosome-positive leukemias.
Leukemia 1992;6(11):1107-12.
1992: Marieke von Lindern; DA Breems; Sjozef van Baal; H Adriaansen; Gerard C Grosveld
Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia.
Genes, chromosomes & cancer 1992;5(3):227-34.
1992: Marieke von Lindern; Maarten Fornerod; N Soekarman; Sjozef van Baal; M Jaegle; Anne Hagemeijer; Dirk Bootsma; Gerard C Grosveld
Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene.
Baillière's clinical haematology 1992;5(4):857-79.
1992: Marieke von Lindern; Sjozef van Baal; J Wiegant; A Raap; Anne Hagemeijer; Gerard C Grosveld
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.
Molecular and cellular biology 1992;12(8):3346-55.
1992: D Soekarman; Marieke von Lindern; S Daenen; B de Jong; C Fonatsch; Barbara Heinze; C Bartram; Anne Hagemeijer; Gerard C Grosveld
The translocation (6;9) (p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features.
Blood 1992;79(11):2990-7.
1992: Dies Meijer; A Graus; Gerard C Grosveld
Mapping the transactivation domain of the Oct-6 POU transcription factor.
Nucleic acids research 1992;20(9):2241-7.
1992: Marieke von Lindern; Maarten Fornerod; Sjozef van Baal; M Jaegle; Ton de Wit; Arjan Buijs; Gerard C Grosveld
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.
Molecular and cellular biology 1992;12(4):1687-97.
1992: Jan M A van Deursen; Jan Schepens; W Peters; Dies Meijer; Gerard C Grosveld; Wiljan Hendriks; Bé Wieringa
Genetic variability of the murine creatine kinase B gene locus and related pseudogenes in different inbred strains of mice.
Genomics 1992;12(2):340-9.
1991: D C van der Plas; D Soekarman; A M van Gent; Gerard C Grosveld; Anne Hagemeijer
bcr-abl mRNA lacking abl exon a2 detected by polymerase chain reaction in a chronic myelogeneous leukemia patient.
Leukemia 1991;5(6):457-61.
1991: D C van der Plas; Gerard C Grosveld; Anne Hagemeijer
Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML.
Cancer genetics and cytogenetics 1991;52(2):143-56.
1990: Dies Meijer; A Graus; R Kraay; An Langeveld; M P Mulder; Gerard C Grosveld
The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells.
Nucleic acids research 1990;18(24):7357-65.
1990: Marieke von Lindern; Annemarie Poustka; H Lerach; Gerard C Grosveld
The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.
Molecular and cellular biology 1990;10(8):4016-26.
1990: J van Denderen; D van der Plas; T Meeuwsen; N Zegers; W Boersma; Gerard C Grosveld; Willem van Ewijk
Immunologic characterization of the tumor-specific bcr-abl junction in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Blood 1990;76(1):136-41.
1990: D Soekarman; J van Denderen; Lies Hoefsloot; M Moret; T Meeuwsen; J van Baal; Anne Hagemeijer; Gerard C Grosveld
A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Leukemia 1990;4(6):397-403.
1990: L Selleri; Marieke von Lindern; A Hermans; Dies Meijer; G Torelli; Gerard C Grosveld
Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript.
Blood 1990;75(5):1146-53.
1990: Anne Hagemeijer; D C van der Plas; D Soekarman; J van Denderen; Gerard C Grosveld
The Philadelphia translocation in CML and ALL: recent investigations, new detection methods.
Nouvelle revue française d'hématologie 1990;32(1):83-6.
1989: D C van der Plas; A B Hermans; D Soekarman; Elisabeth M E Smit; A de Klein; Nicole Véronique Smadja; G Alimena; R Goudsmit; Gerard C Grosveld; Anne Hagemeijer
Cytogenetic and molecular analysis in Philadelphia negative CML.
Blood 1989;73(4):1038-44.
1989: J Groffen; A Hermans; Gerard C Grosveld; N Heisterkamp
Molecular analysis of chromosome breakpoints.
Progress in nucleic acid research and molecular biology 1989;36():281-300.
1989: Marieke von Lindern; Ton van Agthoven; Anne Hagemeijer; H Adriaansen; Gerard C Grosveld
The human pim-1 gene is not directly activated by the translocation (6;9) in acute nonlymphocytic leukemia.
Oncogene 1989;4(1):75-9.
1989: J van Denderen; A Hermans; T Meeuwsen; C Troelstra; N Zegers; W Boersma; Gerard C Grosveld; Willem van Ewijk
Antibody recognition of the tumor-specific bcr-abl joining region in chronic myeloid leukemia.
The Journal of experimental medicine 1989;169(1):87-98.
1988: A Hermans; L Selleri; J Gow; Gerard C Grosveld
Absence of alternative splicing in bcr-abl mRNA in chronic myeloid leukemia cell lines.
Blood 1988;72(6):2066-9.
1988: A Hermans; J Gow; L Selleri; Marieke von Lindern; Anne Hagemeijer; LM Wiedemann; Gerard C Grosveld
bcr-abl oncogene activation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Leukemia 1988;2(10):628-33.
1987: Dies Meijer; A Hermans; Marieke von Lindern; Ton van Agthoven; Annelies de Klein; P Mackenbach; A Grootegoed; D Talarico; G Della Valle; Gerard C Grosveld
Molecular characterization of the testis specific c-abl mRNA in mouse.
The EMBO journal 1987;6(13):4041-8.
1987: Annelies de Klein; C R Bartram; A Hagemeijer; N Heisterkamp; K Stam; J Groffen; Gerard C Grosveld
The c-abl oncogene in chronic myelogenous leukemia.
Haematologica 1987;72(6 Suppl):19-22.
1987: A Hermans; N Heisterkamp; M von Linden; Sjozef van Baal; Dies Meijer; D van der Plas; LM Wiedemann; J Groffen; Dirk Bootsma; Gerard C Grosveld
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.
Cell 1987;51(1):33-40.
1987: Gerard C Grosveld; A Hermans; Annelies de Klein; Dirk Bootsma; N Heisterkamp; J Groffen
The role of the Philadelphia translocation in chronic myelocytic leukemia.
Annals of the New York Academy of Sciences 1987;511():262-9.
1986: Annelies de Klein; Ton van Agthoven; C Groffen; N Heisterkamp; J Groffen; Gerard C Grosveld
Molecular analysis of both translocation products of a Philadelphia-positive CML patient.
Nucleic acids research 1986;14(17):7071-82.
1986: Gerard C Grosveld; T Verwoerd; Ton van Agthoven; Annelies de Klein; K L Ramachandran; N Heisterkamp; K Stam; J Groffen
The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.
Molecular and cellular biology 1986;6(2):607-16.
1986: Annelies de Klein; A Hermans; Dirk Bootsma; Gerard C Grosveld; N Heisterkamp; K Stam; J Groffen
The role of the Philadelphia translocation in chronic myelocytic leukemia.
Annals of clinical research 1986;18(5-6):278-83.
1985: K Stam; N Heisterkamp; Gerard C Grosveld; Annelies de Klein; R S Verma; M Coleman; H Dosik; J Groffen
Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.
The New England journal of medicine 1985;313(23):1429-33.
1985: Anne Hagemeijer; A de Klein; E Gödde-Salz; C Turc-Carel; Elisabeth M E Smit; Ton van Agthoven; Gerard C Grosveld
Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.
Cancer genetics and cytogenetics 1985;18(2):95-104.
1985: N Heisterkamp; K Stam; J Groffen; Annelies de Klein; Gerard C Grosveld
Structural organization of the bcr gene and its role in the Ph' translocation.
Nature 1985;315(6022):758-61.
1984: J Groffen; J R Stephenson; N Heisterkamp; C Bartram; A de Klein; Gerard C Grosveld
The human c-abl oncogene in the Philadelphia translocation.
Journal of cellular physiology. Supplement 1984;3():179-91.
1983: C R Bartram; Annelies de Klein; Anne Hagemeijer; Ton van Agthoven; A Geurts van Kessel; Dirk Bootsma; Gerard C Grosveld; M A Ferguson-Smith; T Davies; M Stone
Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.
Nature 1983;306(5940):277-80.