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Darlene Groth

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Kurt Giles; David V Glidden; Smita Patel; Carsten Korth; Darlene Groth; Azucena Lemus; Stephen J DeArmond; Stanley B Prusiner
Human prion strain selection in transgenic mice.
David W Colby; Qiang Zhang; Shuyi Wang; Darlene Groth; Giuseppe Legname; Detlev Riesner; Stanley B Prusiner
Prion detection by an amyloid seeding assay.
Jiri G Safar; Klaus Kellings; Ana Serban; Darlene Groth; James E Cleaver; Stanley B Prusiner; Detlev Riesner
Search for a prion-specific nucleic acid.

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All Publications

2010: Kurt Giles; David V Glidden; Smita Patel; Carsten Korth; Darlene Groth; Azucena Lemus; Stephen J DeArmond; Stanley B Prusiner
Human prion strain selection in transgenic mice.
Annals of neurology 2010;68(2):151-61.
2007: David W Colby; Qiang Zhang; Shuyi Wang; Darlene Groth; Giuseppe Legname; Detlev Riesner; Stanley B Prusiner
Prion detection by an amyloid seeding assay.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20914-9.
2005: Jiri G Safar; Klaus Kellings; Ana Serban; Darlene Groth; James E Cleaver; Stanley B Prusiner; Detlev Riesner
Search for a prion-specific nucleic acid.
Journal of virology 2005;79(16):10796-806.
2004: Patrick Tremblay; Haydn L Ball; Kiyotoshi Kaneko; Darlene Groth; Ramanujan S Hegde; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Jiri G Safar
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
Journal of virology 2004;78(4):2088-99.
2003: Carsten Korth; Kiyotoshi Kaneko; Darlene Groth; Norbert Heye; Glenn C Telling; James A Mastrianni; Piero Parchi; Pierluigi Gambetti; Robert Will; James Ironside; Cornelia Heinrich; Patrick Tremblay; Stephen J DeArmond; Stanley B Prusiner
Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4784-9.
2002: Jiri G Safar; Michael Scott; Jeff Monaghan; Camille Deering; Svetlana Didorenko; Julie Vergara; Haydn Ball; Giuseppe Legname; Estelle Leclerc; Laura Solforosi; Hana Serban; Darlene Groth; Dennis R Burton; Stanley B Prusiner; R Anthony Williamson
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.
Nature biotechnology 2002;20(11):1147-50.
2001: Yoichi Matsunaga; David Peretz; A Williamson; D Burton; IR Mehlhorn; Darlene Groth; Fred Cohen; Stanley B Prusiner; Michael A Baldwin
Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH.
Proteins 2001;44(2):110-8.
2001: Jesús R Requena; Darlene Groth; Giuseppe Legname; Earl R Stadtman; Stanley B Prusiner; Rodney L Levine
Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7170-5.
2001: David Peretz; Michael R Scott; Darlene Groth; R Anthony Williamson; Dennis R Burton; Fred Cohen; Stanley B Prusiner
Strain-specified relative conformational stability of the scrapie prion protein.
Protein science : a publication of the Protein Society 2001;10(4):854-63.
2000: D A Stephenson; K Chiotti; C Ebeling; Darlene Groth; Stephen J DeArmond; Stanley B Prusiner; George A Carlson
Quantitative trait loci affecting prion incubation time in mice.
Genomics 2000;69(1):47-53.
2000: Ilia Baskakov; C Aagaard; IR Mehlhorn; Holger Wille; Darlene Groth; Michael A Baldwin; Stanley B Prusiner; Fred Cohen
Self-assembly of recombinant prion protein of 106 residues.
Biochemistry 2000;39(10):2792-804.
2000: Kiyotoshi Kaneko; Haydn L Ball; Holger Wille; Hui Zhang; Darlene Groth; M Torchia; Patrick Tremblay; Jiri G Safar; Stanley B Prusiner; Stephen J DeArmond; Michael A Baldwin; Fred Cohen
A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.
Journal of molecular biology 2000;295(4):997-1007.
1999: Ramanujan S Hegde; Patrick Tremblay; Darlene Groth; Stephen J DeArmond; Stanley B Prusiner; Vishwanath R Lingappa
Transmissible and genetic prion diseases share a common pathway of neurodegeneration.
Nature 1999;402(6763):822-6.
1999: Jörg Tatzelt; Darlene Groth; M Torchia; Stanley B Prusiner; Stephen J DeArmond
Kinetics of prion protein accumulation in the CNS of mice with experimental scrapie.
Journal of neuropathology and experimental neurology 1999;58(12):1244-9.
1999: Pauline M Rudd; T Endo; Cristina Colominas; Darlene Groth; Susan F Wheeler; David Harvey; Mark R Wormald; Hana Serban; Stanley B Prusiner; Akira Kobata; Raymond A Dwek
Glycosylation differences between the normal and pathogenic prion protein isoforms.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13044-9.
1999: H Liu; Shauna Farr-Jones; Nikolai B Ulyanov; M Llinas; Susan Marqusee; Darlene Groth; Fred Cohen; Stanley B Prusiner; Tom L James
Solution structure of Syrian hamster prion protein rPrP(90-231).
Biochemistry 1999;38(17):5362-77.
1998: Jiri G Safar; Holger Wille; V Itri; Darlene Groth; Hana Serban; M Torchia; Fred Cohen; Stanley B Prusiner
Eight prion strains have PrP(Sc) molecules with different conformations.
Nature medicine 1998;4(10):1157-65.
1997: Michael R Scott; Jiri G Safar; Glenn C Telling; O Nguyen; Darlene Groth; M Torchia; R Koehler; Patrick Tremblay; Dirk Walther; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14279-84.
1997: DG Donne; JH Viles; Darlene Groth; IR Mehlhorn; Tom L James; Fred Cohen; Stanley B Prusiner; Peter Wright; H Jane Dyson
Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13452-7.
1997: Stephen J DeArmond; H Sánchez; F Yehiely; Y Qiu; A Ninchak-Casey; V Daggett; A P Camerino; J Cayetano; M Rogers; Darlene Groth; M Torchia; Patrick Tremblay; Michael R Scott; Fred Cohen; Stanley B Prusiner
Selective neuronal targeting in prion disease.
Neuron 1997;19(6):1337-48.
1997: Michael R Scott; Darlene Groth; Jörg Tatzelt; M Torchia; Patrick Tremblay; Stephen J DeArmond; Stanley B Prusiner
Propagation of prion strains through specific conformers of the prion protein.
Journal of virology 1997;71(12):9032-44.
1997: Tom L James; H Liu; Nikolai B Ulyanov; Shauna Farr-Jones; Hui Zhang; DG Donne; Kiyotoshi Kaneko; Darlene Groth; IR Mehlhorn; Stanley B Prusiner; Fred Cohen
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10086-91.
1997: Hui Zhang; J Stockel; IR Mehlhorn; Darlene Groth; Michael A Baldwin; Stanley B Prusiner; Tom L James; Fred Cohen
Physical studies of conformational plasticity in a recombinant prion protein.
Biochemistry 1997;36(12):3543-53.
1997: George A Carlson; S Banks; D Lund; CM Reichert; Darlene Groth; M Torchia; Stephen J DeArmond; Stanley B Prusiner
Failure to transmit disease from gray tremor mutant mice.
Journal of virology 1997;71(3):2342-5.
1996: Margarita Diez; J Koistinaho; Stephen J DeArmond; A P Camerino; Darlene Groth; J C Caytano; Stanley B Prusiner; Tomas Hökfelt
Aberrant induction of neuropeptide Y mRNA in hippocampal CA3 pyramidal neurones in scrapie-infected mice.
Neuroreport 1996;7(12):1887-92.
1996: IR Mehlhorn; Darlene Groth; J Stöckel; Barbara Moffat; D Reilly; D Yansura; W S Willett; M Baldwin; Robert J Fletterick; Fred Cohen; Richard Vandlen; D Henner; Stanley B Prusiner
High-level expression and characterization of a purified 142-residue polypeptide of the prion protein.
Biochemistry 1996;35(17):5528-37.
1996: Detlev Riesner; K Kellings; K Post; Holger Wille; Hana Serban; Darlene Groth; Michael A Baldwin; Stanley B Prusiner
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.
Journal of virology 1996;70(3):1714-22.
1994: KK Hsiao; Darlene Groth; Michael Scott; S L Yang; Hana Serban; D Rapp; D Foster; M Torchia; Stephen J DeArmond; Stanley B Prusiner
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):9126-30.
1994: G A Carlson; C Ebeling; S L Yang; Glenn C Telling; M Torchia; Darlene Groth; David Westaway; Stephen J DeArmond; Stanley B Prusiner
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5690-4.
1994: Michael A Baldwin; K M Pan; J Nguyen; Z Huang; Darlene Groth; A Serban; M Gasset; IR Mehlhorn; Robert J Fletterick; Fred Cohen
Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):435-41.
1994: Stephen J DeArmond; S L Yang; J Cayetano-Canlas; Darlene Groth; Stanley B Prusiner
The neuropathological phenotype in transgenic mice expressing different prion protein constructs.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):415-23.
1994: David Westaway; Stephen J DeArmond; J Cayetano-Canlas; Darlene Groth; D Foster; S L Yang; M Torchia; G A Carlson; Stanley B Prusiner
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins.
Cell 1994;76(1):117-29.
1993: K M Pan; M Baldwin; J Nguyen; M Gasset; A Serban; Darlene Groth; IR Mehlhorn; Z Huang; Robert J Fletterick; Fred Cohen
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):10962-6.
1993: Stanley B Prusiner; Darlene Groth; A Serban; R Koehler; D Foster; M Torchia; D Burton; S L Yang; Stephen J DeArmond
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10608-12.
1993: Stephen J DeArmond; S L Yang; A Lee; R Bowler; A Taraboulos; Darlene Groth; Stanley B Prusiner
Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6449-53.
1993: Michael Scott; Darlene Groth; D Foster; M Torchia; S L Yang; Stephen J DeArmond; Stanley B Prusiner
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.
Cell 1993;73(5):979-88.
1993: Stanley B Prusiner; Darlene Groth; A Serban; Neil stahl; Ruth Gabizon
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2793-7.
1991: N Meyer; V Rosenbaum; B Schmidt; K Gilles; C Mirenda; Darlene Groth; Stanley B Prusiner; Detlev Riesner
Search for a putative scrapie genome in purified prion fractions reveals a paucity of nucleic acids.
The Journal of general virology 1991;72 ( Pt 1)():37-49.
1991: Karen K. Hsiao Ashe; Michael Scott; D Foster; Stephen J DeArmond; Darlene Groth; Hana Serban; Stanley B Prusiner
Spontaneous neurodegeneration in transgenic mice with prion protein codon 101 proline----leucine substitution.
Annals of the New York Academy of Sciences 1991;640():166-70.
1990: KK Hsiao; Michael Scott; D Foster; Darlene Groth; Stephen J DeArmond; Stanley B Prusiner
Spontaneous neurodegeneration in transgenic mice with mutant prion protein.
Science (New York, N.Y.) 1990;250(4987):1587-90.
1990: Stanley B Prusiner; Michael Scott; D Foster; K M Pan; Darlene Groth; C Mirenda; M Torchia; S L Yang; D Serban; G A Carlson
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.
Cell 1990;63(4):673-86.
1990: M Rogers; A Taraboulos; Michael Scott; Darlene Groth; Stanley B Prusiner
Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites.
Glycobiology 1990;1(1):101-9.
1989: Michael Scott; D Foster; C Mirenda; D Serban; F Coufal; M Wälchli; M Torchia; Darlene Groth; G Carlson; S J DeArmond; D Westaway; S B Prusiner
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.
Cell 1989;59(5):847-57.
1989: T Haraguchi; S Fisher; S Olofsson; T Endo; Darlene Groth; AL Tarentino; David R Borchelt; David B Teplow; L Hood; Al L Burlingame
Asparagine-linked glycosylation of the scrapie and cellular prion proteins.
Archives of biochemistry and biophysics 1989;274(1):1-13.
1989: Ruth Gabizon; M P McKinley; Darlene Groth; David Westaway; Stephen J DeArmond; G A Carlson; Stanley B Prusiner
Immunoaffinity purification and neutralization of scrapie prions.
Progress in clinical and biological research 1989;317():583-600.
1988: Ruth Gabizon; M P McKinley; Darlene Groth; Stanley B Prusiner
Immunoaffinity purification and neutralization of scrapie prion infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6617-21.
1988: C G Bellinger-Kawahara; E Kempner; Darlene Groth; Ruth Gabizon; Stanley B Prusiner
Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da.
Virology 1988;164(2):537-41.
1988: Ruth Gabizon; M P McKinley; Darlene Groth; L Kenaga; Stanley B Prusiner
Properties of scrapie prion protein liposomes.
The Journal of biological chemistry 1988;263(10):4950-5.