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Richard Grucza

Research Profile

Disorders

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Physiology

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Publications

TOP 3
Andrew D Plunk; Laura J Bierut; Patricia Cavazaos-Rehg; Richard A Grucza
The persistent effects of minimum legal drinking age laws on drinking patterns later in life.
Patricia A Cavazos-Rehg; Frank J Chaloupka; Richard A Grucza; Melissa J Krauss; Mario Schootman; Edward L Spitznagel; Laura J Bierut
Associations between selected state laws and teenagers' drinking and driving behaviors.
Jaime Derringer; Danielle M Dick; Howard J Edenberg; Alison M Goate; Richard A Grucza; Victor M Hesselbrock; John R Kramer; Robert F Krueger; Peng Lin; Rosalind J Neuman; John I Nurnberger; John P Rice; Scott Saccone; Jay A Tischfield; Arpana Agrawal; Fazil Aliev; Laura J Bierut
The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach.

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All Publications

2013: Andrew D Plunk; Laura J Bierut; Patricia Cavazaos-Rehg; Richard A Grucza
The persistent effects of minimum legal drinking age laws on drinking patterns later in life.
Alcoholism, clinical and experimental research 2013;37(3):463-9.
2012: Patricia A Cavazos-Rehg; Frank J Chaloupka; Richard A Grucza; Melissa J Krauss; Mario Schootman; Edward L Spitznagel; Laura J Bierut
Associations between selected state laws and teenagers' drinking and driving behaviors.
Alcoholism, clinical and experimental research 2012;36(9):1647-52.
2012: Jaime Derringer; Danielle M Dick; Howard J Edenberg; Alison M Goate; Richard A Grucza; Victor M Hesselbrock; John R Kramer; Robert F Krueger; Peng Lin; Rosalind J Neuman; John I Nurnberger; John P Rice; Scott Saccone; Jay A Tischfield; Arpana Agrawal; Fazil Aliev; Laura J Bierut
The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach.
Behavior genetics 2012;42(4):626-35.
2012: Li-Shiun Chen; Richard A Grucza; Dorothy Hatsukami; Eric O Johnson; Nancy L Saccone; Jen C Wang; Hong Xian; Naomi Breslau; Laura J Bierut
Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.
Drug and alcohol dependence 2012;123 Suppl 1():S42-51.
2012: Li-Shiun Chen; Alison M Goate; Richard A Grucza; Dorothy Hatsukami; Eric O Johnson; John P Rice; Nancy L Saccone; Scott F Saccone; Stevens S Smith; Jen C Wang; Timothy B Baker; Naomi Breslau; Laura J Bierut
Dissection of the phenotypic and genotypic associations with nicotinic dependence.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2012;14(4):425-33.
2012: Laura J Bierut; N Breslau; Kathleen K Bucholz; A Agrawal; Sarah Bertelsen; T Foroud; Louis Fox; Alison Goate; Richard A Grucza; Victor Hesselbrock; E O Johnson; J Kramer; Samuel Kuperman; John Nurnberger; Bernice Porjesz; John P Rice; Nancy L Saccone; Marc Schuckit; Jay Tischfield; Jen C Wang; Howard J Edenberg
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.
Molecular psychiatry 2012;17(4):445-50.
2012: Patricia A Cavazos-Rehg; Linda Cottler; Richard A Grucza; Martin Iguchi; Melissa J Krauss; Mario Schootman; Edward L Spitznagel; Laura Jean Bierut
Associations between sexuality education in schools and adolescent birthrates: a state-level longitudinal model.
Archives of pediatrics & adolescent medicine 2012;166(2):134-40.
2012: Richard A Grucza; Pamela R Hipp; Karen E Norberg; Laura Rundell; Patricia Cavazos-Rehg; Anastasia Evanoff; Laura J Bierut
The legacy of minimum legal drinking age law changes: long-term effects on suicide and homicide deaths among women.
Alcoholism, clinical and experimental research 2012;36(2):377-84.
2011: Robert C Culverhouse; Nancy L Saccone; Jerry A Stitzel; Jen C Wang; Joseph H Steinbach; Alison Goate; Tae-Hwi Schwantes-An; Richard A Grucza; Victoria L Stevens; Laura J Bierut
Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.
Human genetics 2011;129(2):177-88.
2010: Richard A Grucza; Robert F Krueger; Susan B Racette; Karen E Norberg; Pamela R Hipp; Laura J Bierut
The emerging link between alcoholism risk and obesity in the United States.
Archives of general psychiatry 2010;67(12):1301-8.
2010: Eric O Johnson; Li-Shiun Chen; Naomi Breslau; Dorothy Hatsukami; Tania Robbins; Nancy L Saccone; Richard A Grucza; Laura J Bierut
Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
Addiction (Abingdon, England) 2010;105(11):2014-22.
2010: Jaime Derringer; Robert F Krueger; Danielle M Dick; Scott Saccone; Richard A Grucza; Arpana Agrawal; Peng Lin; Laura A Almasy; Howard J Edenberg; Tatiana Foroud; John I Nurnberger; Victor M Hesselbrock; John R Kramer; Samuel Kuperman; Bernice Porjesz; Marc A Schuckit; Laura J Bierut
Predicting sensation seeking from dopamine genes. A candidate-system approach.
Psychological science 2010;21(9):1282-90.
2010: Richard A Grucza; Eric O Johnson; Robert F Krueger; Naomi Breslau; Nancy L Saccone; Li-Shiun Chen; Jaime Derringer; Arpana Agrawal; michael lynskey; Laura J Bierut
Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.
Addiction biology 2010;15(3):346-57.
2010: Silvia S Martins; Katherine Margaret Keyes; Carla Storr; Hong Zhu; Richard A Grucza
Birth-cohort trends in lifetime and past-year prescription opioid-use disorder resulting from nonmedical use: results from two national surveys.
Journal of studies on alcohol and drugs 2010;71(4):480-7.
2009: Karen E Norberg; Laura J Bierut; Richard A Grucza
Long-term effects of minimum drinking age laws on past-year alcohol and drug use disorders.
Alcoholism, clinical and experimental research 2009;33(12):2180-90.
2009: Arpana Agrawal; Carolyn E Sartor; michael lynskey; Julia D Grant; Michele L Pergadia; Richard A Grucza; Kathleen K Bucholz; Elliot C Nelson; Pamela A F Madden; Nicholas G Martin; Andrew C Heath
Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms.
Alcoholism, clinical and experimental research 2009;33(12):2047-56.
2009: Nancy L Saccone; Jen C Wang; Naomi Breslau; Eric O Johnson; Dorothy Hatsukami; Scott F Saccone; Richard A Grucza; Lingwei Sun; Weimin Duan; John Budde; Robert C Culverhouse; Louis Fox; Anthony L Hinrichs; Joseph Henry Steinbach; Meng Wu; John P Rice; Alison Goate; Laura J Bierut
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
Cancer research 2009;69(17):6848-56.
2009: Jen C Wang; Carlos Cruchaga; Nancy L Saccone; Sarah Bertelsen; Pengyuan Liu; John Budde; Weimin Duan; Louis Fox; Richard A Grucza; Jason Kern; Kevin Mayo; Oliver Reyes; John Rice; Scott F Saccone; Noah Spiegel; Joseph H Steinbach; Jerry A Stitzel; Marshall W Anderson; Ming You; Victoria L Stevens; Laura J Bierut; Alison Goate
Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
Human molecular genetics 2009;18(16):3125-35.
2009: Richard A Grucza; Karen E Norberg; Laura J Bierut
Binge drinking among youths and young adults in the United States: 1979-2006.
Journal of the American Academy of Child and Adolescent Psychiatry 2009;48(7):692-702.
2009: Nancy L Saccone; Scott F Saccone; Anthony L Hinrichs; Jerry A Stitzel; Weimin Duan; Michele L Pergadia; Arpana Agrawal; Naomi Breslau; Richard A Grucza; Dorothy Hatsukami; Eric O Johnson; Pamela A F Madden; Gary E Swan; Jen C Wang; Alison Goate; John P Rice; Laura J Bierut
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(4):453-66.
2009: Vivia V McCutcheon; Andrew C Heath; Howard J Edenberg; Richard A Grucza; Victor M Hesselbrock; John R Kramer; Laura J Bierut; Kathleen K Bucholz
Alcohol criteria endorsement and psychiatric and drug use disorders among DUI offenders: greater severity among women and multiple offenders.
Addictive behaviors 2009;34(5):432-9.
2009: Jen C Wang; Richard A Grucza; C Cruchaga; Anthony L Hinrichs; Sarah Bertelsen; John Budde; Louis Fox; E Goldstein; O Reyes; Nancy L Saccone; Scott F Saccone; Xiaoling Xuei; Kathleen K Bucholz; Samuel Kuperman; John Nurnberger; John P Rice; Marc Schuckit; Jay Tischfield; Victor Hesselbrock; Bernice Porjesz; Howard J Edenberg; Laura J Bierut; Alison Goate
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.
Molecular psychiatry 2009;14(5):501-10.
2008: Richard A Grucza; Jen C Wang; Jerry A Stitzel; Anthony L Hinrichs; Scott F Saccone; Nancy L Saccone; Kathleen K Bucholz; C Robert Cloninger; Rosalind J Neuman; John Budde; Louis Fox; Sarah Bertelsen; John Kramer; Victor Hesselbrock; Jay Tischfield; John I Nurnberger; Laura A Almasy; Bernice Porjesz; Samuel Kuperman; Marc A Schuckit; Howard J Edenberg; John P Rice; Alison Goate; Laura J Bierut
A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence.
Biological psychiatry 2008;64(11):922-9.
2008: Richard A Grucza; Karen Norberg; Kathleen K Bucholz; Laura J Bierut
Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States.
Alcoholism, clinical and experimental research 2008;32(8):1493-501.
2008: Richard A Grucza; Kathleen K Bucholz; John P Rice; Laura J Bierut
Secular trends in the lifetime prevalence of alcohol dependence in the United States: a re-evaluation.
Alcoholism, clinical and experimental research 2008;32(5):763-70.
2008: Danielle M Dick; Fazil Aliev; Jen C Wang; Richard A Grucza; Marc Schuckit; Samuel Kuperman; John Kramer; Anthony L Hinrichs; Sarah Bertelsen; John Budde; Victor Hesselbrock; Bernice Porjesz; Howard J Edenberg; Laura J Bierut; Alison Goate
Using dimensional models of externalizing psychopathology to aid in gene identification.
Archives of general psychiatry 2008;65(3):310-8.
2008: Arpana Agrawal; Anthony L Hinrichs; Gerald Dunn; Sarah Bertelsen; Danielle M Dick; Scott F Saccone; Nancy L Saccone; Richard A Grucza; Jen C Wang; C Robert Cloninger; Howard J Edenberg; Tatiana Foroud; Victor Hesselbrock; John Kramer; Kathleen K Bucholz; Samuel Kuperman; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Alison Goate; Laura J Bierut
Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample.
Drug and alcohol dependence 2008;93(1-2):12-20.
2008: Nancy L Saccone; Scott F Saccone; Alison Goate; Richard A Grucza; Anthony L Hinrichs; John P Rice; Laura J Bierut
In search of causal variants: refining disease association signals using cross-population contrasts.
BMC genetics 2008;9():58.
2008: Richard A Grucza; Thomas R Przybeck; C Robert Cloninger
Screening for alcohol problems: an epidemiological perspective and implications for primary care.
Missouri medicine 2008;105(1):67-71.
2007: Richard A Grucza; Lewis R Goldberg
The comparative validity of 11 modern personality inventories: predictions of behavioral acts, informant reports, and clinical indicators.
Journal of personality assessment 2007;89(2):167-87.
2007: Richard A Grucza; Anna M Abbacchi; Thomas R Przybeck; Joseph C Gfroerer
Discrepancies in estimates of prevalence and correlates of substance use and disorders between two national surveys.
Addiction (Abingdon, England) 2007;102(4):623-9.
2007: Richard A Grucza; Thomas R Przybeck; C Robert Cloninger
Prevalence and correlates of binge eating disorder in a community sample.
Comprehensive psychiatry 2007;48(2):124-31.
2006: Richard A Grucza; Laura J Bierut
Cigarette smoking and the risk for alcohol use disorders among adolescent drinkers.
Alcoholism, clinical and experimental research 2006;30(12):2046-54.
2006: Richard A Grucza; C Robert Cloninger; Kathleen K Bucholz; John N Constantino; Marc I Schuckit; Danielle M Dick; Laura J Bierut
Novelty seeking as a moderator of familial risk for alcohol dependence.
Alcoholism, clinical and experimental research 2006;30(7):1176-83.
2006: Richard A Grucza; Laura J Bierut
Co-occurring risk factors for alcohol dependence and habitual smoking: update on findings from the Collaborative Study on the Genetics of Alcoholism.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2006;29(3):172-8.
2005: Renee M Cunningham-Williams; Richard A Grucza; Linda B Cottler; Sharon B Womack; Samantha J Books; Thomas R Przybeck; Edward L Spitznagel; C Robert Cloninger
Prevalence and predictors of pathological gambling: results from the St. Louis personality, health and lifestyle (SLPHL) study.
Journal of psychiatric research 2005;39(4):377-90.
2005: Richard A Grucza; Thomas R Przybeck; C Robert Cloninger
Personality as a mediator of demographic risk factors for suicide attempts in a community sample.
Comprehensive psychiatry 2005;46(3):214-22.
2003: Sangaralingam Kumaran; Richard A Grucza; Gabriel Waksman
The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14828-33.
2003: Richard A Grucza; Thomas R Przybeck; Edward L Spitznagel; C Robert Cloninger
Personality and depressive symptoms: a multi-dimensional analysis.
Journal of affective disorders 2003;74(2):123-30.
2000: Richard A Grucza; J Michael Bradshaw; V Mitaxov; Gabriel Waksman
Role of electrostatic interactions in SH2 domain recognition: salt-dependence of tyrosyl-phosphorylated peptide binding to the tandem SH2 domain of the Syk kinase and the single SH2 domain of the Src kinase.
Biochemistry 2000;39(33):10072-81.
1999: Richard A Grucza; J Michael Bradshaw; Klaus Fütterer; Gabriel Waksman
SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
Medicinal research reviews 1999;19(4):273-93.
1999: Richard A Grucza; Klaus Fütterer; A C Chan; Gabriel Waksman
Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide: evidence for two conformers.
Biochemistry 1999;38(16):5024-33.
1998: Klaus Fütterer; J Wong; Richard A Grucza; A C Chan; Gabriel Waksman
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
Journal of molecular biology 1998;281(3):523-37.
1998: J Michael Bradshaw; Richard A Grucza; John E Ladbury; Gabriel Waksman
Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.
Biochemistry 1998;37(25):9083-90.
1996: Stéphane Réty; Klaus Fütterer; Richard A Grucza; C M Munoz; W A Frazier; Gabriel Waksman
pH-Dependent self-association of the Src homology 2 (SH2) domain of the Src homologous and collagen-like (SHC) protein.
Protein science : a publication of the Protein Society 1996;5(3):405-13.