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Tilman Grune

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Chemicals & Drugs

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Konstantinos Grintzalis; Tilman Grune; Daniela Weber; Dimitrios Zisimopoulos; Christos D Georgiou
Method for the simultaneous determination of free/protein malondialdehyde and lipid/protein hydroperoxides.
Marc Kästle; Esther Woschee; Tilman Grune
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
Stefanie Grimm; Annika Höhn; Melanie Hörlacher; Christiane Ott; Daniela Weber; Tilman Grune
Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1.

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All Publications

2013: Konstantinos Grintzalis; Tilman Grune; Daniela Weber; Dimitrios Zisimopoulos; Christos D Georgiou
Method for the simultaneous determination of free/protein malondialdehyde and lipid/protein hydroperoxides.
Free radical biology & medicine 2013;59():27-35.
2012: Marc Kästle; Esther Woschee; Tilman Grune
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
Free radical biology & medicine 2012;53(11):2092-101.
2012: Stefanie Grimm; Annika Höhn; Melanie Hörlacher; Christiane Ott; Daniela Weber; Tilman Grune
Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1.
The Biochemical journal 2012;448(1):127-39.
2012: Annika Höhn; Tobias Jung; Anna Sittig; Stefanie Grimm; Tilman Grune
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.
Free radical biology & medicine 2012;53(9):1760-9.
2012: Marc Kästle; Sandra Reeg; Adelina Rogowska-Wrzesinska; Tilman Grune
Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress.
Free radical biology & medicine 2012;53(7):1468-77.
2012: Jose Pedro Castro; Tilman Grune; Tobias Jung; Christiane Ott; Henrique Almeida
Carbonylation of the cytoskeletal protein actin leads to aggregate formation.
Free radical biology & medicine 2012;53(4):916-25.
2012: Tobias Jung; Tilman Grune
Experimental basis for discriminating between thermal and athermal effects of water-filtered infrared A irradiation.
Annals of the New York Academy of Sciences 2012;1259():33-8.
2012: Stefanie Grimm; Annika Hoehn; Melanie Horlacher; Thomas Reinheckel; Betül Catalgol; Tilman Grune
Cathepsins D and L reduce the toxicity of advanced glycation end products.
Free radical biology & medicine 2012;52(6):1011-23.
2012: Helmut Sies; Wilhelm Stahl; Hans K Biesalski; Tilman Grune; Peter C H Hollman; Gary Williamson
Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference.
Advances in nutrition (Bethesda, Md.) 2012;3(2):217-21.
2012: Daniela Weber; Nicole Kneschke; Ina Bergheim; Nicolle Breusing; Stefanie Grimm; Tilman Grune
Rapid and sensitive determination of protein-nitrotyrosine by ELISA: Application to human plasma.
Free radical research 2012;46(3):276-85.
2012: Tobias Jung; Anne-Marie Lau; Helmut Piazena; Annika Höhn; Tilman Grune
An experimental setup for the measurement of nonthermal effects during water-filtered infrared A-irradiation of mammalian cell cultures.
Photochemistry and photobiology 2012;88(2):371-80.
2012: Banu Bayram; Insa M A Ernst; Jan Frank; Stefanie Grimm; Tilman Grune; Beraat Ozcelik; Thomas Roeder; Charlotte Schrader; Anika E Wagner; Gerald Rimbach
A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression.
Rejuvenation research 2012;15(1):71-81.
2012: Daniela Weber; Tilman Grune
The contribution of β-carotene to vitamin A supply of humans.
Molecular nutrition & food research 2012;56(2):251-8.
2012: Tilman Grune
Preface.
Progress in molecular biology and translational science 2012;109():xi-xiii.
2012: Betul Catalgol; Tilman Grune
Proteasome and neurodegeneratıve diseases.
Progress in molecular biology and translational science 2012;109():397-414.
2012: Marc Kästle; Tilman Grune
Interactions of the proteasomal system with chaperones: protein triage and protein quality control.
Progress in molecular biology and translational science 2012;109():113-60.
2012: Tobias Jung; Tilman Grune
Structure of the proteasome.
Progress in molecular biology and translational science 2012;109():1-39.
2011: Tilman Grune; Anke Licht; Jenny K Ngo; Andrew M Pickering; Betül Catalgol; Gennady Ermak; Kelvin J A Davies
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress.
Free radical biology & medicine 2011;51(7):1355-64.
2011: Marc Kästle; Tilman Grune
Proteins bearing oxidation-induced carbonyl groups are not preferentially ubiquitinated.
Biochimie 2011;93(6):1076-9.
2011: Annika Höhn; Tobias Jung; Stefanie Grimm; Betül Catalgol; Daniela Weber; Tilman Grune
Lipofuscin inhibits the proteasome by binding to surface motifs.
Free radical biology & medicine 2011;50(5):585-91.
2011: Marc Kästle; Stefanie Grimm; Rena Nagel; Nicolle Breusing; Tilman Grune
Combination of PDT and inhibitor treatment affects melanoma cells and spares keratinocytes.
Free radical biology & medicine 2011;50(2):305-12.
2011: Miguel Roehrs; Juliana Valentini; Natália Brucker; Rachel Bulcão; Geni Burg; Mariele Charão; Marta Duarte; Fernando Freitas; Tilman Grune; Mirna Leal; Angela Moro; Clóvis Paniz; Solange C Garcia
The relationships between exogenous and endogenous antioxidants with the lipid profile and oxidative damage in hemodialysis patients.
BMC nephrology 2011;12():59.
2011: Stefanie Grimm; Dagmar Mvondo; Tilman Grune; Nicolle Breusing
The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1.
BioFactors (Oxford, England) 2011;37(1):17-24.
2011: Edina Bakondi; Betul Catalgol; Istvan Bak; Tobias Jung; Perinur Bozaykut; Mehmet Bayramicli; Nesrin Kartal Ozer; Tilman Grune
Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity.
Free radical biology & medicine 2011;50(1):86-92.
2011: Stefanie Grimm; Annika Hoehn; Kelvin J Davies; Tilman Grune
Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease.
Free radical research 2011;45(1):73-88.
2010: Andrew M Pickering; Alison L Koop; Cheryl Y Teoh; Gennady Ermak; Tilman Grune; Kelvin J A Davies
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes.
The Biochemical journal 2010;432(3):585-94.
2010: Tilman Grune; Georg Lietz; Andreu Palou; A Catharine Ross; Wilhelm Stahl; Guangweng Tang; David I Thurnham; Shi-an Yin; Hans K Biesalski
Beta-carotene is an important vitamin A source for humans.
The Journal of nutrition 2010;140(12):2268S-2285S.
2010: Christina Schiborr; Gunter P Eckert; Jakob Weissenberger; Walter E Müller; Dorothea Schwamm; Tilman Grune; Gerald Rimbach; Jan Frank
Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake.
Current pharmaceutical biotechnology 2010;11(8):861-7.
2010: Werner Siems; Carlo Crifo; Elisabetta Capuozzo; Koji Uchida; Tilman Grune; Costantino Salerno
Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes.
Archives of biochemistry and biophysics 2010;503(2):248-52.
2010: Anne Negre-Salvayre; Nathalie Auge; Victoria Ayala; Huveyda Basaga; Jordi Boada; Rainer Brenke; Sarah Chapple; gUY Cohen; Janos Feher; Tilman Grune; Gabriella Lengyel; Giovanni E Mann; Reinald Pamplona; Giuseppe Poli; Manuel Portero-Otin; Yael Riahi; Robert Salvayre; Shlomo Sasson; Jose Serrano; Ofer Shamni; Werner Siems; Richard C M Siow; Ingrid Wiswedel; Kamelija Zarkovic; Neven Zarkovic
Pathological aspects of lipid peroxidation.
Free radical research 2010;44(10):1125-71.
2010: Tilman Grune; Neven Zarkovic; Kostelidou Kalliopi
Lipid peroxidation research in Europe and the COST B35 action 'Lipid Peroxidation Associated Disorders'.
Free radical research 2010;44(10):1095-7.
2010: Nicolle Breusing; Tilman Grune
Biomarkers of protein oxidation from a chemical, biological and medical point of view.
Experimental gerontology 2010;45(10):733-7.
2010: Hans K Biesalski; Tilman Grune; Jana Tinz; Iris Zöllner; Jeffrey B Blumberg
Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials.
Nutrients 2010;2(9):929-49.
2010: Stefanie Grimm; Lisa Ernst; Nicole Grötzinger; Annika Höhn; Nicolle Breusing; Thomas Reinheckel; Tilman Grune
Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins.
Free radical research 2010;44(9):1013-26.
2010: Tilman Grune; Diana Botzen; Martina Engels; Peter Voss; Barbara Kaiser; Tobias Jung; Stefanie Grimm; Gennady Ermak; Kelvin J A Davies
Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions.
Archives of biochemistry and biophysics 2010;500(2):181-8.
2010: Annika Höhn; Tobias Jung; Stefanie Grimm; Tilman Grune
Lipofuscin-bound iron is a major intracellular source of oxidants: role in senescent cells.
Free radical biology & medicine 2010;48(8):1100-8.
2010: Nicolle Breusing; Stefanie Grimm; Dagmar Mvondo; Andrea Flaccus; Hans Konrad Biesalski; Tilman Grune
Light-induced cytotoxicity after aminolevulinic acid treatment is mediated by heme and not by iron.
Journal of photochemistry and photobiology. B, Biology 2010;99(1):36-43.
2010: Betul Catalgol; Brigitte Wendt; Stephanie Grimm; Nicolle Breusing; Nesrin Kartal Ozer; Tilman Grune
Chromatin repair after oxidative stress: role of PARP-mediated proteasome activation.
Free radical biology & medicine 2010;48(5):673-80.
2010: Tobias Jung; Annika Höhn; Tilman Grune
Lipofuscin: detection and quantification by microscopic techniques.
Methods in molecular biology (Clifton, N.J.) 2010;594():173-93.
2010: Tobias Jung; Annika Höhn; Helmut Piazena; Tilman Grune
Effects of water-filtered infrared A irradiation on human fibroblasts.
Free radical biology & medicine 2010;48(1):153-60.
2009: Nicolle Breusing; Jana Arndt; Peter Voss; Nicolaus Bresgen; Ingrid Wiswedel; Andreas Gardemann; Werner Siems; Tilman Grune
Inverse correlation of protein oxidation and proteasome activity in liver and lung.
Mechanisms of ageing and development 2009;130(11-12):748-53.
2009: Betul Catalgol; Isabella Ziaja; Nicolle Breusing; Tobias Jung; Annika Höhn; Buket Alpertunga; Peter Schroeder; Niki Chondrogianni; Efstathios S Gonos; Isabelle Petropoulos; Bertrand Friguet; Lars-Oliver Klotz; Jean Krutmann; Tilman Grune
The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression.
The Journal of biological chemistry 2009;284(44):30076-86.
2009: Olaf Sommerburg; Nicole Karius; Werner Siems; Claus-Dieter Langhans; Michael Leichsenring; Nicolle Breusing; Tilman Grune
Proteasomal degradation of beta-carotene metabolite--modified proteins.
BioFactors (Oxford, England) 2009;35(5):449-59.
2009: Lucia Rackova; Vladimír Snirc; Tobias Jung; Milan Stefek; Cimen Karasu; Tilman Grune
Metabolism-induced oxidative stress is a mediator of glucose toxicity in HT22 neuronal cells.
Free radical research 2009;43(9):876-86.
2009: Tobias Jung; Betül Catalgol; Tilman Grune
The proteasomal system.
Molecular aspects of medicine 2009;30(4):191-296.
2009: Miguel Roehrs; Juliana Valentini; Rachel Bulcão; José Cláudio Moreira; Hanz Biesalski; Renata P Limberger; Tilman Grune; Solange C Garcia
The plasma retinol levels as pro-oxidant/oxidant agents in haemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(7):2212-8.
2009: Miriam Strosova; Jana Karlovska; Corinne M Spickett; Tilman Grune; Zuzana Orszagova; Lubica Horakova
Oxidative injury induced by hypochlorous acid to Ca-ATPase from sarcoplasmic reticulum of skeletal muscle and protective effect of trolox.
General physiology and biophysics 2009;28(2):195-209.
2009: Albrecht Stroh; Johannes Boltze; Katharina Sieland; Katharina Hild; Cindy Gutzeit; Tobias Jung; Jenny Kressel; Susann Hau; Doreen Reich; Tilman Grune; Claus Zimmer
Impact of magnetic labeling on human and mouse stem cells and their long-term magnetic resonance tracking in a rat model of Parkinson disease.
Molecular imaging 2009;8(3):166-78.
2009: Tobias Jung; Annika Höhn; Betul Catalgol; Tilman Grune
Age-related differences in oxidative protein-damage in young and senescent fibroblasts.
Archives of biochemistry and biophysics 2009;483(1):127-35.
2009: B Catalgol; Tilman Grune
Protein pool maintenance during oxidative stress.
Current pharmaceutical design 2009;15(26):3043-51.
2008: Tobias Jung; Tilman Grune
The proteasome and its role in the degradation of oxidized proteins.
IUBMB life 2008;60(11):743-52.
2008: Peter Voss; Martina Engels; Miriam Strosova; Tilman Grune; Lubica Horakova
Protective effect of antioxidants against sarcoplasmic reticulum (SR) oxidation by Fenton reaction, however without prevention of Ca-pump activity.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(7):1726-33.
2008: Miriam Strosova; Peter Voss; Martina Engels; Lubica Horakova; Tilman Grune
Limited degradation of oxidized calmodulin by proteasome: formation of peptides.
Archives of biochemistry and biophysics 2008;475(1):50-4.
2008: Thomas Kueper; Tilman Grune; Gesa-Meike Muhr; Holger Lenz; Klaus-Peter Wittern; Horst Wenck; Franz Stäb; Thomas Blatt
Modification of vimentin: a general mechanism of nonenzymatic glycation in human skin.
Annals of the New York Academy of Sciences 2008;1126():328-32.
2008: Nicolle Breusing; Tilman Grune
Regulation of proteasome-mediated protein degradation during oxidative stress and aging.
Biological chemistry 2008;389(3):203-9.
2008: Nurgül Aytan; Tobias Jung; Faruk Tamtürk; Tilman Grune; Nesrin Kartal Ozer
Oxidative stress related changes in the brain of hypercholesterolemic rabbits.
BioFactors (Oxford, England) 2008;33(3):225-36.
2008: Helen R Griffiths; Tilman Grune; Efstathios Gonos; Nesrin Kartal Ozer
Report of Society for Free Radical Research Europe Summer School.
BioFactors (Oxford, England) 2008;33(2):157-60.
2007: Clóvis Paniz; André Bairros; Juliana Valentini; Mariele Charão; Rachel Bulcão; Angélica V Moro; Tilman Grune; Solange C Garcia
The influence of the serum vitamin C levels on oxidative stress biomarkers in elderly women.
Clinical biochemistry 2007;40(18):1367-72.
2007: Tilman Grune; Mette M Berger
Markers of oxidative stress in ICU clinical settings: present and future.
Current opinion in clinical nutrition and metabolic care 2007;10(6):712-7.
2007: Tobias Jung; Nicolle Breusing; Tilman Grune
Lipofuscin: formation, distribution, and metabolic consequences.
Annals of the New York Academy of Sciences 2007;1119():97-111.
2007: Nicolle Breusing; Tobias Jung; Tilman Grune
The proteasome and its role in nuclear protein maintenance.
Experimental gerontology 2007;42(9):864-70.
2007: Thomas Kueper; Tilman Grune; Stefanie Prahl; Holger Lenz; Vivienne Welge; Tanja Biernoth; Yvonne Vogt; Gesa-Meike Muhr; Astrid Gaemlich; Tobias Jung; Gerrit Boemke; Hans-Peter Elsässer; Klaus-Peter Wittern; Horst Wenck; Franz Stäb; Thomas Blatt
Vimentin is the specific target in skin glycation. Structural prerequisites, functional consequences, and role in skin aging.
The Journal of biological chemistry 2007;282(32):23427-36.
2007: Rebecca Widmer; Barbara Kaiser; Martina Engels; Tobias Jung; Tilman Grune
Hyperammonemia causes protein oxidation and enhanced proteasomal activity in response to mitochondria-mediated oxidative stress in rat primary astrocytes.
Archives of biochemistry and biophysics 2007;464(1):1-11.
2007: Tobias Jung; Nicolle Breusing; Tilman Grune
Oxidized proteins: intracellular distribution and recognition by the proteasome.
Archives of biochemistry and biophysics 2007;462(2):231-7.
2007: Peter Voss; Hossein Hajimiragha; Martina Engels; Carsten Ruhwiedel; Christian Calles; Peter Schroeder; Tilman Grune
Irradiation of GAPDH: a model for environmentally induced protein damage.
Biological chemistry 2007;388(6):583-92.
2007: Yvonne Steffen; Tobias Jung; Lars-Oliver Klotz; Tankred Schewe; Tilman Grune; Helmut Sies
Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin.
Free radical biology & medicine 2007;42(7):955-70.
2007: Tobias Jung; Martina Engels; Lars-Oliver Klotz; Klaus-Dietrich Kröncke; Tilman Grune
Nitrotyrosine and protein carbonyls are equally distributed in HT22 cells after nitrosative stress.
Free radical biology & medicine 2007;42(6):773-86.
2007: Rebecca Widmer; Martina Engels; Peter Voss; Tilman Grune
Postanoxic damage of microglial cells is mediated by xanthine oxidase and cyclooxygenase.
Free radical research 2007;41(2):145-52.
2007: Boris Görg; Natalia Qvartskhava; Peter Voss; Tilman Grune; Dieter Häussinger; Freimut Schliess
Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration.
FEBS letters 2007;581(1):84-90.
2007: Diana Botzen; Tilman Grune
Degradation of HNE-modified proteins--possible role of ubiquitin.
Redox report : communications in free radical research 2007;12(1):63-7.
2007: Peter Voss; Tilman Grune
The nuclear proteasome and the degradation of oxidatively damaged proteins.
Amino acids 2007;32(4):527-34.
2006: Diana Poppek; Susi Keck; Gennady Ermak; Tobias Jung; Alexandra Stolzing; Oliver Ullrich; Kelvin J A Davies; Tilman Grune
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress.
The Biochemical journal 2006;400(3):511-20.
2006: Rebecca Widmer; Isabella Ziaja; Tilman Grune
Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.
Free radical research 2006;40(12):1259-68.
2006: Nicolle Breusing; Tilman Grune
Protein oxidation and proteolysis.
Biological chemistry 2006;387(10-11):1351-5.
2006: Jana Mehlhase; Jeanette Gieche; Rebecca Widmer; Tilman Grune
Ferritin levels in microglia depend upon activation: modulation by reactive oxygen species.
Biochimica et biophysica acta 2006;1763(8):854-9.
2006: Peter Voss; Lubica Horakova; Manuela Jakstadt; Daniela Kiekebusch; Tilman Grune
Ferritin oxidation and proteasomal degradation: protection by antioxidants.
Free radical research 2006;40(7):673-83.
2006: Alexandra Stolzing; Rebecca Widmer; Tobias Jung; Peter Voss; Tilman Grune
Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material.
Free radical biology & medicine 2006;40(12):2126-35.
2006: Ivonne Petermann; Christian Mayer; Jörg Stypmann; Martin L Biniossek; Desmond J Tobin; Markus A Engelen; Thomas Dandekar; Tilman Grune; Lorenz Schild; Christoph Peters; Thomas Reinheckel
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1266-8.
2006: Lizette Gil; Werner Siems; Birgit Mazurek; Johann Gross; Peter Schroeder; Peter Voss; Tilman Grune
Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes.
Free radical research 2006;40(5):495-505.
2006: Tobias Jung; Martina Engels; Barbara Kaiser; Diana Poppek; Tilman Grune
Intracellular distribution of oxidized proteins and proteasome in HT22 cells during oxidative stress.
Free radical biology & medicine 2006;40(8):1303-12.
2006: Alexandra Stolzing; Rebecca Widmer; Tobias Jung; Peter Voss; Tilman Grune
Degradation of glycated bovine serum albumin in microglial cells.
Free radical biology & medicine 2006;40(6):1017-27.
2006: Diana Poppek; Tilman Grune
Proteasomal defense of oxidative protein modifications.
Antioxidants & redox signaling 2006;8(1-2):173-84.
2006: Michele Mishto; Elena Bellavista; Aurelia Santoro; Alexandra Stolzing; Claudia Ligorio; Benedetta Nacmias; Liana Spazzafumo; Martina Chiappelli; Federico Licastro; Sandro Sorbi; Andrea Pession; Thomas Ohm; Tilman Grune; Claudio Franceschi
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains.
Neurobiology of aging 2006;27(1):54-66.
2005: Tilman Grune; Katrin Merker; Tobias Jung; Nicolle Sitte; Kelvin J A Davies
Protein oxidation and degradation during postmitotic senescence.
Free radical biology & medicine 2005;39(9):1208-15.
2005: Mohammad Reza Lornejad-Schäfer; Ute Albrecht; Diana Poppek; Thor Gehrmann; Tilman Grune; Johannes Bode; Dieter Häussinger; Freimut Schliess
Osmotic regulation of STAT3 stability in H4IIE rat hepatoma cells.
FEBS letters 2005;579(25):5791-7.
2005: Jana Mehlhase; Grit Sandig; Kostas Pantopoulos; Tilman Grune
Oxidation-induced ferritin turnover in microglial cells: role of proteasome.
Free radical biology & medicine 2005;38(2):276-85.
2005: Werner Siems; Stephan Quast; Daniela Peter; Wolfgang Augustin; francesco carluccio; Tilman Grune; Alex Sevanian; Hannelore Hampl; Ingrid Wiswedel
Oxysterols are increased in plasma of end-stage renal disease patients.
Kidney & blood pressure research 2005;28(5-6):302-6.
2005: Werner Siems; francesco carluccio; Sonja Radenkovic; Tilman Grune; Hannelore Hampl
Oxidative stress in renal anemia of hemodialysis patients is mitigated by epoetin treatment.
Kidney & blood pressure research 2005;28(5-6):295-301.
2005: Oleksii A Skorokhod; Evelin Schwarzer; Tilman Grune; Paolo Arese
Role of 4-hydroxynonenal in the hemozoin-mediated inhibition of differentiation of human monocytes to dendritic cells induced by GM-CSF/IL-4.
BioFactors (Oxford, England) 2005;24(1-4):283-9.
2005: Werner Siems; Tilman Grune; Peter Voss; Rainer Brenke
Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite.
BioFactors (Oxford, England) 2005;24(1-4):275-82.
2005: Katrin Merker; Doreen Hapke; Kristian Reckzeh; Hartmut Schmidt; Herbert Lochs; Tilman Grune
Copper related toxic effects on cellular protein metabolism in human astrocytes.
BioFactors (Oxford, England) 2005;24(1-4):255-61.
2005: Rebecca Widmer; Tilman Grune
Iron uptake of the normoxic, anoxic and postanoxic microglial cell line RAW 264.7.
BioFactors (Oxford, England) 2005;24(1-4):247-54.
2005: Tobias Jung; Martina Engels; Barbara Kaiser; Tilman Grune
Distribution of oxidized and HNE-modified proteins in U87 cells.
BioFactors (Oxford, England) 2005;24(1-4):165-70.
2005: Werner Siems; Tilman Grune; Olaf Sommerburg; Leopold Flohé; Enrique Cadenas
HNE and Further Lipid Peroxidation Products.
BioFactors (Oxford, England) 2005;24(1-4):1-4.
2005: Mohammad Lornejad-Schafer; Christine Schafer; Lisa Richter; Tilman Grune; Dieter Haussinger; Freimut Schliess
Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;16(4-6):193-206.
2005: Alexandra Stolzing; Sebastian Sethe; Tilman Grune
Chronically active: activation of microglial proteolysis in ageing and neurodegeneration.
Redox report : communications in free radical research 2005;10(4):207-13.
2005: Lizette Gil; Daniel Pérez; Rolando Tápanes; Jorge Pérez; Tilman Grune
Does mitochondrial dysfunction during antiretroviral therapy in human immunodeficiency virus infection suggest antioxidant supplementation as a beneficial option?
Redox report : communications in free radical research 2005;10(3):113-9.
2004: Tilman Grune; Tobias Jung; Katrin Merker; Kelvin J A Davies
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.
The international journal of biochemistry & cell biology 2004;36(12):2519-30.
2004: Ursula Felderhoff-Mueser; Petra Bittigau; Marco Sifringer; Bozena Jarosz; Elzbieta Korobowicz; Lieselotte Mahler; Turid Piening; Axel Moysich; Tilman Grune; Friederike Thor; Rolf Heumann; Christoph Bührer; Chrysanthy Ikonomidou
Oxygen causes cell death in the developing brain.
Neurobiology of disease 2004;17(2):273-82.
2004: Albrecht Stroh; Claus Zimmer; Cindy Gutzeit; Manuela Jakstadt; Franziska Marschinke; Tobias Jung; Herbert Pilgrimm; Tilman Grune
Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages.
Free radical biology & medicine 2004;36(8):976-84.
2004: Alexandra Stolzing; Tilman Grune
Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(6):743-5.
2004: Andrea Ernst; Alexandra Stolzing; Grit Sandig; Tilman Grune
Protein oxidation and the degradation of oxidized proteins in the rat oligodendrocyte cell line OLN 93-antioxidative effect of the intracellular spin trapping agent PBN.
Brain research. Molecular brain research 2004;122(2):126-32.
2004: Sharon Judge; Andrew R Judge; Tilman Grune; Christiaan Leeuwenburgh
Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(2):R254-9.
2004: Klaus Schäfer; Antonios Kyriakopoulos; Hildegard Gessner; Tilman Grune; Dietrich Behne
Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2004;18(1):89-97.
2004: Andrea Ernst; Alexandra Stolzing; Grit Sandig; Tilman Grune
Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells.
Archives of biochemistry and biophysics 2004;421(1):54-60.
2003: Marcus Clauss; Karin Lason; Janin Gehrke; Matthias Lechner-Doll; Joerns Fickel; Tilman Grune; W Jürgen Streich
Captive roe deer (Capreolus capreolus) select for low amounts of tannic acid but not quebracho: fluctuation of preferences and potential benefits.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;136(2):369-82.
2003: Katrin Merker; Oliver Ullrich; Hartmut Schmidt; Nicolle Sitte; Tilman Grune
Stability of the nuclear protein turnover during cellular senescence of human fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1963-5.
2003: Tilman Grune
[Protein oxidation in the aging of skin fibroblasts].
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete 2003;54(9):818-21.
2003: Tilman Grune; Kelvin J A Davies
The proteasomal system and HNE-modified proteins.
Molecular aspects of medicine 2003;24(4-5):195-204.
2003: Werner Siems; Tilman Grune
Intracellular metabolism of 4-hydroxynonenal.
Molecular aspects of medicine 2003;24(4-5):167-75.
2003: Thorsten R Doeppner; Tilman Grune; Herbert de Groot; Ursula Rauen
Cold-induced apoptosis of rat liver endothelial cells: involvement of the proteasome.
Transplantation 2003;75(12):1946-53.
2003: Tilman Grune; Katrin Merker; Grit Sandig; Kelvin J A Davies
Selective degradation of oxidatively modified protein substrates by the proteasome.
Biochemical and biophysical research communications 2003;305(3):709-18.
2003: Susi Keck; Robert Nitsch; Tilman Grune; Oliver Ullrich
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease.
Journal of neurochemistry 2003;85(1):115-22.
2003: Darius P Buchczyk; Tilman Grune; Helmut Sies; Lars-Oliver Klotz
Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome.
Biological chemistry 2003;384(2):237-41.
2003: Alexandra Stolzing; Tilman Grune
Impairment of protein homeostasis and decline of proteasome activity in microglial cells from adult Wistar rats.
Journal of neuroscience research 2003;71(2):264-71.
2003: Reshma Shringarpure; Tilman Grune; Jana Mehlhase; Kelvin J A Davies
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.
The Journal of biological chemistry 2003;278(1):311-8.
2003: Hans K Biesalski; M Berneburg; Tilman Grune; Martina Kerscher; J Krutmann; W Raab; J Reimann; Tilmann Reuther; L Robert; T Schwarz
Hohenheimer Consensus Talk. Oxidative and premature skin ageing.
Experimental dermatology 2003;12 Suppl 3():3-15.
2003: L'ubica Horáková; Anke Licht; Grit Sandig; Manuela Jakstadt; Zdenka Duracková; Tilman Grune
Standardized extracts of flavonoids increase the viability of PC12 cells treated with hydrogen peroxide: effects on oxidative injury.
Archives of toxicology 2003;77(1):22-9.
2002: Werner G Siems; R Brenke; A Beier; Tilman Grune
Oxidative stress in chronic lymphoedema.
QJM : monthly journal of the Association of Physicians 2002;95(12):803-9.
2002: Jenny Arnold; Tilman Grune
PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation?
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(11):1060-5.
2002: Tilman Grune; Thomas Reinheckel; James A North; Rui Li; Paloma B Bescos; Reshma Shringarpure; Kelvin J A Davies
Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1602-10.
2002: Matthias Pirlich; Karoline Kiok; Grit Sandig; Herbert Lochs; Tilman Grune
Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells.
Neuroscience letters 2002;328(2):93-6.
2002: Matthias Pirlich; Cornelia Müller; Grit Sandig; Manuela Jakstadt; Nicolle Sitte; Herbert Lochs; Tilman Grune
Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells.
Free radical biology & medicine 2002;33(2):283-91.
2002: Colin Selman; Tilman Grune; Alexandra Stolzing; Manuela Jakstadt; Jane S McLaren; John R Speakman
The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis.
Free radical biology & medicine 2002;33(2):259-65.
2002: Olaf Sommerburg; Tilman Grune; Jochen H H Ehrich; Werner G Siems
Adaptation of glutathion-peroxidase activity to oxidative stress occurs in children but not in adult patients with end-stage renal failure undergoing hemodialysis.
Clinical nephrology 2002;58 Suppl 1():S31-6.
2002: francesco carluccio; Werner Siems; G Stefanelli; Olaf Sommerburg; Tilman Grune; Eberhard Riedel; Hannelore Hampl
Homocysteine in chronic renal failure in relation to renal anemia and to oxidative stress parameters 4-hydroxynonenal and malondialdehyde.
Clinical nephrology 2002;58 Suppl 1():S26-30.
2002: Werner Siems; francesco carluccio; Tilman Grune; M Jakstadt; Stephan Quast; Hannelore Hampl; Olaf Sommerburg
Elevated serum concentration of cardiotoxic lipid peroxidation products in chronic renal failure in relation to severity of renal anemia.
Clinical nephrology 2002;58 Suppl 1():S20-5.
2002: Alexandra Stolzing; Antje Wengner; Tilman Grune
Degradation of oxidized extracellular proteins by microglia.
Archives of biochemistry and biophysics 2002;400(2):171-9.
2002: Jana Mehlhase; Tilman Grune
Proteolytic response to oxidative stress in mammalian cells.
Biological chemistry 2002;383(3-4):559-67.
2002: Tilman Grune; Thomas Reinheckel; Rui Li; James A North; Kelvin J A Davies
Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells.
Archives of biochemistry and biophysics 2002;397(2):407-13.
2001: Alexandra Stolzing; Tilman Grune
The proteasome and its function in the ageing process.
Clinical and experimental dermatology 2001;26(7):566-72.
2001: Oliver Ullrich; Tilman Grune
Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells.
Free radical biology & medicine 2001;31(7):887-93.
2001: Tilman Grune; Klaus Krämer; Peter P Hoppe; W Siems
Enrichment of eggs with n-3 polyunsaturated fatty acids: effects of vitamin E supplementation.
Lipids 2001;36(8):833-8.
2001: Oliver Ullrich; Antje Diestel; Ingo Bechmann; M Homberg; Tilman Grune; Ralf Hass; Robert Nitsch
Turnover of oxidatively damaged nuclear proteins in BV-2 microglial cells is linked to their activation state by poly-ADP-ribose polymerase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(8):1460-2.
2001: Katrin Merker; Alexandra Stolzing; Tilman Grune
Proteolysis, caloric restriction and aging.
Mechanisms of ageing and development 2001;122(7):595-615.
2001: Jeanette Gieche; Jana Mehlhase; A Licht; T Zacke; Nicolle Sitte; Tilman Grune
Protein oxidation and proteolysis in RAW264.7 macrophages: effects of PMA activation.
Biochimica et biophysica acta 2001;1538(2-3):321-8.
2001: Nicolle Sitte; Katrin Merker; Tilman Grune; Thomas von Zglinicki
Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress.
Experimental gerontology 2001;36(3):475-86.
2000: Nicolle Sitte; Katrin Merker; Thomas von Zglinicki; Kelvin J A Davies; Tilman Grune
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II--aging of nondividing cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2503-10.
2000: Nicolle Sitte; Katrin Merker; Thomas von Zglinicki; Tilman Grune; Kelvin J A Davies
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2495-502.
2000: Jana Mehlhase; Jeanette Gieche; Oliver Ullrich; Nicolle Sitte; Tilman Grune
LPS-induced protein oxidation and proteolysis in BV-2 microglial cells.
IUBMB life 2000;50(4-5):331-5.
2000: Katrin Merker; Tilman Grune
Proteolysis of oxidised proteins and cellular senescence.
Experimental gerontology 2000;35(6-7):779-86.
2000: M Rudeck; T Volk; Nicolle Sitte; Tilman Grune
Ferritin oxidation in vitro: implication of iron release and degradation by the 20S proteasome.
IUBMB life 2000;49(5):451-6.
2000: T Reinheckel; Oliver Ullrich; Nicolle Sitte; Tilman Grune
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress.
Archives of biochemistry and biophysics 2000;377(1):65-8.
2000: Nicolle Sitte; Katrin Merker; Thomas von Zglinicki; Tilman Grune
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts.
Free radical biology & medicine 2000;28(5):701-8.
2000: Katrin Merker; Nicolle Sitte; Tilman Grune
Hydrogen peroxide-mediated protein oxidation in young and old human MRC-5 fibroblasts.
Archives of biochemistry and biophysics 2000;375(1):50-4.
2000: K Ludat; Olaf Sommerburg; Tilman Grune; Werner G Siems; Eberhard Riedel; Hannelore Hampl
Oxidation parameters in complete correction of renal anemia.
Clinical nephrology 2000;53(1 Suppl):S30-5.
2000: Olaf Sommerburg; Tilman Grune; Hannelore Hampl; Eberhard Riedel; Jochen H H Ehrich; Werner G Siems
Does treatment of renal anemia with recombinant erythropoietin influence oxidative stress in hemodialysis patients?
Clinical nephrology 2000;53(1 Suppl):S23-9.
2000: Tilman Grune; Olaf Sommerburg; Werner G Siems
Oxidative stress in anemia.
Clinical nephrology 2000;53(1 Suppl):S18-22.
2000: Werner G Siems; Olaf Sommerburg; Tilman Grune
Erythrocyte free radical and energy metabolism.
Clinical nephrology 2000;53(1 Suppl):S9-17.
1999: Oliver Ullrich; T Reinheckel; Nicolle Sitte; Tilman Grune
Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome.
Free radical biology & medicine 1999;27(5-6):487-92.
1999: P Mayer-Kuckuk; O Ullrich; Mathias Ziegler; Tilman Grune; Manfred Schweiger
Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro.
Biochemical and biophysical research communications 1999;259(3):576-81.
1999: Oliver Ullrich; T Reinheckel; Nicolle Sitte; Ralf Hass; Tilman Grune; Kelvin J A Davies
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6223-8.
1999: Werner G Siems; R Brenke; Olaf Sommerburg; Tilman Grune
Improved antioxidative protection in winter swimmers.
QJM : monthly journal of the Association of Physicians 1999;92(4):193-8.
1999: Oliver Ullrich; Nicolle Sitte; Olaf Sommerburg; V Sandig; Kelvin J A Davies; Tilman Grune
Influence of DNA binding on the degradation of oxidized histones by the 20S proteasome.
Archives of biochemistry and biophysics 1999;362(2):211-6.
1999: Bernd Luther; C Lehmann; Tilman Grune; R Meyer; G Schwenke; H Beutel; K Bürger
[Controlled reperfusion of ischemic extremity musculature to prevent free radical induced lesions].
Zentralblatt für Chirurgie 1999;124(4):336-43.
1998: Nicolle Sitte; Katrin Merker; Tilman Grune
Proteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts.
FEBS letters 1998;440(3):399-402.
1998: T Reinheckel; Nicolle Sitte; Oliver Ullrich; U Kuckelkorn; Kelvin J A Davies; Tilman Grune
Comparative resistance of the 20S and 26S proteasome to oxidative stress.
The Biochemical journal 1998;335 ( Pt 3)():637-42.
1998: K Mertsch; Tilman Grune; S Kunstmann; Burkhard Wiesner; A M Ladhoff; W G Siems; Reiner F Haseloff; Ingolf E Blasig
Protective effects of the thiophosphate amifostine (WR 2721) and a lazaroid (U83836E) on lipid peroxidation in endothelial cells during hypoxia/reoxygenation.
Biochemical pharmacology 1998;56(8):945-54.
1998: Olaf Sommerburg; Tilman Grune; Hannelore Hampl; Eberhard Riedel; Frederik J G M van Kuijk; Jochen H H Ehrich; Werner G Siems
Does long-term treatment of renal anaemia with recombinant erythropoietin influence oxidative stress in haemodialysed patients?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(10):2583-7.
1998: Olaf Sommerburg; Oliver Ullrich; Nicolle Sitte; D von Zglinicki; Werner Siems; Tilman Grune
Dose- and wavelength-dependent oxidation of crystallins by UV light--selective recognition and degradation by the 20S proteasome.
Free radical biology & medicine 1998;24(9):1369-74.
1998: Tilman Grune; Ingolf E Blasig; Nicolle Sitte; Birgit Roloff; Reiner F Haseloff; Kelvin J A Davies
Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome.
The Journal of biological chemistry 1998;273(18):10857-62.
1998: Werner G Siems; A M Pimenov; H Esterbauer; Tilman Grune
Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in thymocytes as an effective secondary antioxidative defense mechanism.
Journal of biochemistry 1998;123(3):534-9.
1997: Werner G Siems; Elisabetta Capuozzo; D Verginelli; Costantino Salerno; Carlo Crifò; Tilman Grune
Inhibition of NADPH oxidase-mediated superoxide radical formation in PMA-stimulated human neutrophils by 4-hydroxynonenal--binding to -SH and -NH2 groups.
Free radical research 1997;27(4):353-8.
1997: Oliver Ullrich; Tilman Grune
Detection of 8-hydroxydeoxyguanosine in K562 human hematopoietic cells by high-performance capillary electrophoresis.
Journal of chromatography. B, Biomedical sciences and applications 1997;697(1-2):243-9.
1997: Tilman Grune; Werner G Siems; T Petras
Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney.
Journal of lipid research 1997;38(8):1660-5.
1997: A Schwendel; Tilman Grune; Herrman G Holzhütter; Werner G Siems
Models for the regulation of purine metabolism in rat hepatocytes: evaluation of tracer kinetic experiments.
The American journal of physiology 1997;273(1 Pt 1):G239-46.
1997: Tilman Grune; Thomas Reinheckel; Kelvin J A Davies
Degradation of oxidized proteins in mammalian cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(7):526-34.
1997: Werner G Siems; H Zollner; Tilman Grune; H Esterbauer
Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product.
Journal of lipid research 1997;38(3):612-22.
1997: Tilman Grune; P Michel; N Sitte; W Eggert; H Albrecht-Nebe; H Esterbauer; Werner G Siems
Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases.
Free radical biology & medicine 1997;23(3):357-60.
1996: S Kunstmann; K Mertsch; I E Blasig; Tilman Grune
High metabolic rates of 4-hydroxynonenal in brain capillary endothelial cells during hypoxia/reoxygenation.
Brain research 1996;740(1-2):353-5.
1996: Tilman Grune; T Reinheckel; Kelvin J A Davies
Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome.
The Journal of biological chemistry 1996;271(26):15504-9.
1996: Evelin Schwarzer; O Müller; Paolo Arese; W G Siems; Tilman Grune
Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. A possible clue for hemozoin toxicity.
FEBS letters 1996;388(2-3):119-22.
1995: T Petras; Werner G Siems; Tilman Grune
4-hydroxynonenal is degraded to mercapturic acid conjugate in rat kidney.
Free radical biology & medicine 1995;19(5):685-8.
1995: I E Blasig; Tilman Grune; K Schönheit; E Rohde; M Jakstadt; Reiner F Haseloff; Werner G Siems
4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium.
The American journal of physiology 1995;269(1 Pt 2):H14-22.
1995: K Mertsch; Tilman Grune; Werner G Siems; A Ladhoff; N Saupe; I E Blasig
Hypoxia and reoxygenation of brain endothelial cells in vitro: a comparison of biochemical and morphological response.
Cellular and molecular biology (Noisy-le-Grand, France) 1995;41(2):243-53.
1995: Tilman Grune; T Reinheckel; M Joshi; Kelvin J A Davies
Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome.
The Journal of biological chemistry 1995;270(5):2344-51.
1995: Tilman Grune; Olaf Sommerburg; T Petras; Werner G Siems
Postanoxic formation of aldehydic lipid peroxidation products in human renal tubular cells.
Free radical biology & medicine 1995;18(1):21-7.
1995: Werner G Siems; Tilman Grune; H Esterbauer
4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine.
Life sciences 1995;57(8):785-9.
1994: I E Blasig; K Mertsch; A Ladhoff; Tilman Grune
Lipid peroxidation and lipofuscin granula in brain endothelial cell cultures during reoxygenation.
Annals of the New York Academy of Sciences 1994;738():374-7.
1994: Tilman Grune; Werner G Siems; H Zollner; H Esterbauer
Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages.
Cancer research 1994;54(19):5231-5.
1994: A Schwendel; Werner G Siems; Tilman Grune; Herrman G Holzhütter
Transitions of hepatic purine metabolism of Ehrlich ascites tumor bearing mice in different phases of tumor growth.
Biochemistry and molecular biology international 1994;34(3):457-63.
1994: A Beier; W Siems; R Brenke; Tilman Grune
[Increased formation of free radicals in chronic lymphedema].
Zeitschrift für Lymphologie. Journal of lymphology 1994;18(1):8-11.
1994: Tilman Grune; K Schönheit; I Blasig; W Siems
Reduced 4-hydroxynonenal degradation in hearts of spontaneously hypertensive rats during normoxia and postischemic reperfusion.
Cell biochemistry and function 1994;12(2):143-7.
1994: Werner G Siems; A Schwendel; Tilman Grune; Herrman G Holzhütter; R Uhlig
Estimation of metabolic flux rates in liver purine catabolism of tumour-bearing mice by computer simulation of radioactive tracer experiments.
Cell biochemistry and function 1994;12(1):1-9.
1994: Werner G Siems; Tilman Grune; A Schwendel
Adenine nucleotide levels and lipid peroxidation at hypoxia and reoxygenation in different cell types.
Advances in experimental medicine and biology 1994;370():313-8.
1994: A Schwendel; Herrman G Holzhütter; Tilman Grune; W Siems
A study of anoxia in rat hepatocytes.
Advances in experimental medicine and biology 1994;370():307-11.
1994: Tilman Grune; R Mueller; M Jakstadt; H Schmidt; Werner G Siems
Is hypoxanthine a useful marker of perinatal hypoxia?
Advances in experimental medicine and biology 1994;370():295-8.
1993: Werner G Siems; Tilman Grune; H Schmidt; Y V Tikhonov; A M Pimenov
Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor.
Cancer research 1993;53(21):5143-7.
1993: K Müller; Tilman Grune; S Klee; C Jochmann; Fritz Rupert Ungemach; W Siems
Trichlorobromomethane-induced changes of purine nucleotides in hepatocytes.
Biochemistry and molecular biology international 1993;31(3):405-12.
1993: Herrman G Holzhütter; A Schwendel; Tilman Grune; J Quedenau; W Siems
Estimation of steady-state flux rates in metabolic systems by computer simulations of radioactive tracer experiments.
Computer applications in the biosciences : CABIOS 1993;9(5):573-80.
1993: Tilman Grune; W Schneider; Werner G Siems
Reoxygenation injury of rat hepatocytes: evaluation of nucleotide depletion and oxidative stress as causal components.
Cellular and molecular biology (Noisy-le-Grand, France) 1993;39(6):635-50.
1993: Tilman Grune; Werner G Siems
Reversed-phase high-performance liquid chromatography of purine compounds for investigation of biomedical problems: application to different tissues and body fluids.
Journal of chromatography 1993;618(1-2):15-40.
1993: Tilman Grune; G A Ross; H Schmidt; W Siems; D Perrett
Optimized separation of purine bases and nucleosides in human cord plasma by capillary zone electrophoresis.
Journal of chromatography 1993;636(1):105-11.
1993: Tilman Grune; Werner G Siems; K Schönheit; I E Blasig
Release of 4-hydroxynonenal, an aldehydic mediator of inflammation, during postischaemic reperfusion of the myocardium.
International journal of tissue reactions 1993;15(4):145-50.
1992: K Müller; Werner G Siems; Tilman Grune; H David; W Henke; Klaus Jung
Adaptational increase of liver glutathione content during long-term application of cyclosporine A may attenuate toxic side effects.
Cellular and molecular biology (Noisy-le-Grand, France) 1992;38(7):729-38.
1992: Werner G Siems; Tilman Grune; A Werner; G Gerber; P Buntrock; W Schneider
Protective influence of oxypurinol on the trinitrobenzene sulfonic acid(TNB) model of inflammatory bowel disease in rats.
Cellular and molecular biology 1992;38(2):189-99.
1992: Tilman Grune; W Siems; R Uhlig; M Jakstadt
Adenine metabolism of Ehrlich mouse ascites cells in proliferating and resting phase of tumor growth.
Biochemistry international 1992;26(2):199-209.
1992: Werner G Siems; Tilman Grune; B Beierl; H Zollner; H Esterbauer
The metabolism of 4-hydroxynonenal, a lipid peroxidation product, is dependent on tumor age in Ehrlich mouse ascites cells.
EXS 1992;62():124-35.
1991: Tilman Grune; W Siems; J Kowalewski; H Zollner; H Esterbauer
Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by enterocytes of rat small intestine.
Biochemistry international 1991;25(5):963-71.
1991: Tilman Grune; Werner G Siems; G Gerber; R Uhlig
Determination of the ultraviolet absorbance and radioactivity of purine compounds separated by high-performance liquid chromatography. Application to metabolic flux rate analysis.
Journal of chromatography 1991;553(1-2):193-9.
1991: Tilman Grune; W Siems; G Gerber; Y V Tikhonov; A M Pimenov; R T Toguzov
Changes of nucleotide patterns in liver, muscle and blood during the growth of Ehrlich ascites cells: application of the reversed-phase and ion-pair reversed-phase high-performance liquid chromatography with radial compression column.
Journal of chromatography 1991;563(1):53-61.
1991: W Siems; Tilman Grune; A Werner; G Gerber; P Buntrock; W Schneider
Influence of oxypurinol on colitis induced in rat colon by trinitrobenzene sulfonic acid treatment.
Advances in experimental medicine and biology 1991;309A():365-8.
1991: G Gerber; W Siems; A Werner; Wolfgang Dubiel; Tilman Grune; W Henke; W Schneider; M Ziegler
Dynamics in the purine nucleotides of liver during various periods of hypoxia/ischaemia and reoxygenation.
Advances in experimental medicine and biology 1991;309A():259-64.
1991: Werner G Siems; Tilman Grune; H Schmidt; R Uhlig; G Gerber; Y V Tikhonov; A M Pimenov; R T Toguzov
Purine nucleotides, nucleosides and nucleobases of liver, skeletal muscle, blood and tumor cells during the growth of Ehrlich ascites tumor in mice.
Advances in experimental medicine and biology 1991;309A():113-6.
1991: Tilman Grune; W Siems; R Uhlig; P Langen; G Gerber
Changes of purine nucleotide metabolism of Ehrlich ascites cells during transition of tumour growth.
Advances in experimental medicine and biology 1991;309A():109-12.
1990: Tilman Grune; W Siems; A Werner; G Gerber; M Kostić; H Esterbauer
Aldehyde and nucleotide separations by high-performance liquid chromatography. Application to phenylhydrazine-induced damage of erythrocytes and reticulocytes.
Journal of chromatography 1990;520():411-7.
1990: W Schneider; W Siems; Tilman Grune
Balancing of energy-consuming processes of rat hepatocytes.
Cell biochemistry and function 1990;8(4):227-32.
1990: Iu V Tikhonov; A M Pimenov; R T Toguzov; V Zims; Tilman Grune; Kh Shmidt; G Gerber
[Metabolic pool of purine compounds in erythrocytes of mice during growth of transplanted tumors].
Biulleten' eksperimental'noĭ biologii i meditsiny 1990;110(7):39-40.
1990: A Werner; W Siems; Tilman Grune; C Schreiter
Interrelation between nucleotide degradation and aldehyde formation in red blood cells. Influence of xanthine oxidase on metabolism: an application of nucleotide and aldehyde analyses by high-performance liquid chromatography.
Journal of chromatography 1990;507():311-9.
1990: Y V Tikhonov; A M Pimenov; R T Toguzov; Tilman Grune; W Siems; H Schmidt; G Gerber
Metabolism of purine and pyrimidine compounds in erythrocytes of tumor-bearing mice.
Biomedica biochimica acta 1990;49(2-3):S125-8.
1990: W Siems; C Gärtner; D Kranz; W Schneider; Tilman Grune; J Schimke; S Gau; U Wege; G Gerber
Long term effects of monthly low dose whole body irradiation on the glutathione status and thiobarbituric acid-reactive substances in different organs of male Wistar rats.
Radiobiologia, radiotherapia 1990;31(3):257-63.
1989: W Schneider; Tilman Grune; W Siems; A Werner; G Gerber
Nucleotide concentrations in hepatocytes during anoxia and reoxygenation in presence of allopurinol and oxypurinol.
Biomedica biochimica acta 1989;48(2-3):S40-3.