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Renate Grünert

Research Profile

Chemicals & Drugs

Anatomy

Tumor Cell Line

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Physiology

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Publications

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Aron F Westendorf; Julie A Woods; Virginia Appleyard; Nicola J Farrer; Renate Grünert; Katharina Korpis; Karen Murray; Kim Robinson; Peter J Sadler; Luca Salassa; Alastair M Thompson; Patrick J Bednarski
Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism.
Elzbieta Pomarnacka; Maria Gdaniec; Renate Grünert; Maike Heinrichs; Anita Kornicka; Anna Kuchnio; Patrick J Bednarski
Synthesis, cytotoxicity testing, and structure-activity relationships of novel 6-chloro-7-(4-phenylimino-4H-3,1-benzoxazin-2-yl)-3-(substituted)-1,4,2-benzodithiazine 1,1-dioxides.
Fanny Riechert-Krause; Andrea Eick; Renate Grünert; Patrick J Bednarski; Klaus Weisz
In vitro anticancer activity and evaluation of DNA duplex binding affinity of phenyl-substituted indoloquinolines.

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All Publications

2012: Aron F Westendorf; Julie A Woods; Virginia Appleyard; Nicola J Farrer; Renate Grünert; Katharina Korpis; Karen Murray; Kim Robinson; Peter J Sadler; Luca Salassa; Alastair M Thompson; Patrick J Bednarski
Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: a light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism.
Molecular cancer therapeutics 2012;11(9):1894-904.
2011: Elzbieta Pomarnacka; Maria Gdaniec; Renate Grünert; Maike Heinrichs; Anita Kornicka; Anna Kuchnio; Patrick J Bednarski
Synthesis, cytotoxicity testing, and structure-activity relationships of novel 6-chloro-7-(4-phenylimino-4H-3,1-benzoxazin-2-yl)-3-(substituted)-1,4,2-benzodithiazine 1,1-dioxides.
Archiv der Pharmazie 2011;344(7):431-41.
2011: Fanny Riechert-Krause; Andrea Eick; Renate Grünert; Patrick J Bednarski; Klaus Weisz
In vitro anticancer activity and evaluation of DNA duplex binding affinity of phenyl-substituted indoloquinolines.
Bioorganic & medicinal chemistry letters 2011;21(8):2380-3.
2009: Ralph Holl; Bettina Jung; Dirk Schepmann; Hans-Ulrich Humpf; Renate Grünert; Patrick J Bednarski; Werner Englberger; Bernhard Wünsch
Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring.
ChemMedChem 2009;4(12):2111-22.
2009: C Willemann; Renate Grünert; Patrick J Bednarski; Reinhard Troschütz
Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines.
Bioorganic & medicinal chemistry 2009;17(13):4406-19.
2009: Ralph Holl; Dirk Schepmann; Roland Fröhlich; Renate Grünert; Patrick J Bednarski; Bernhard Wünsch
Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity.
Journal of medicinal chemistry 2009;52(7):2126-37.
2009: Ralph Holl; Dirk Schepmann; Patrick J Bednarski; Renate Grünert; Bernhard Wünsch
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity.
Bioorganic & medicinal chemistry 2009;17(4):1445-55.
2009: Ralph Holl; Dirk Schepmann; Renate Grünert; Patrick J Bednarski; Bernhard Wünsch
Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity.
Bioorganic & medicinal chemistry 2009;17(2):777-93.
2007: Christian Geiger; Christel Zelenka; Manuela Weigl; Roland Fröhlich; Birgit Wibbeling; Kirstin Lehmkuhl; Dirk Schepmann; Renate Grünert; Patrick J Bednarski; Bernhard Wünsch
Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.
Journal of medicinal chemistry 2007;50(24):6144-53.
2007: R A A Mothana; Renate Grünert; Ulrike Lindequist; Patrick J Bednarski
Study of the anticancer potential of Yemeni plants used in folk medicine.
Die Pharmazie 2007;62(4):305-7.
2007: Karin Bracht; Manuel Liebeke; Christoph A Ritter; Renate Grünert; Patrick J Bednarski
Correlations between the activities of 19 standard anticancer agents, antioxidative enzyme activities and the expression of ATP-binding cassette transporters: comparison with the National Cancer Institute data.
Anti-cancer drugs 2007;18(4):389-404.
2007: Zdzislaw Brzozowski; Franciszek Saczewski; Jarosław Sławiński; Patrick J Bednarski; Renate Grünert; Maria Gdaniec
Synthesis, structural characterization, and in vitro antitumor activity of novel N-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)arylsulfonamides.
Bioorganic & medicinal chemistry 2007;15(7):2560-72.
2006: Bernd Dotzauer; Renate Grünert; Patrick J Bednarski; Harald Lanig; Jens Landwehr; Reinhard Troschütz
2,4-Diamino-9H-pyrimido[4,5-b]indol-5-ols: synthesis, in vitro cytotoxic activity, and QSAR investigations.
Bioorganic & medicinal chemistry 2006;14(21):7282-92.
2006: Franciszek Saczewski; Ewa Dziemidowicz-Borys; Patrick J Bednarski; Renate Grünert; Maria Gdaniec; Piotr Tabin
Synthesis, crystal structure and biological activities of copper(II) complexes with chelating bidentate 2-substituted benzimidazole ligands.
Journal of inorganic biochemistry 2006;100(8):1389-98.
2006: Patrick J Bednarski; Renate Grünert; Michael Zielzki; Anja Wellner; Fiona S Mackay; Peter J Sadler
Light-activated destruction of cancer cell nuclei by platinum diazide complexes.
Chemistry & biology 2006;13(1):61-7.
2006: Karin Bracht; Renate Grünert; Patrick J Bednarski
Correlations between the activities of 19 anti-tumor agents and the intracellular glutathione concentrations in a panel of 14 human cancer cell lines: comparisons with the National Cancer Institute data.
Anti-cancer drugs 2006;17(1):41-51.
2004: Karin Bracht; Christian Neumann; Renate Grünert; Patrick J Bednarski
No correlation between GSH levels in human cancer cell lines and the cell growth inhibitory activities of platinum diamine complexes.
Archiv der Pharmazie 2004;337(12):668-71.
2004: Franciszek Saczewski; Przemyslaw Reszka; Maria Gdaniec; Renate Grünert; Patrick J Bednarski
Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Journal of medicinal chemistry 2004;47(13):3438-49.
2003: Christian Neumann; Renate Grünert; Patrick J Bednarski
Nicotinamide adenine dinucleotide phosphate-regenerating system coupled to a glutathione-reductase microtiter method for determination of total glutathione concentrations in adherent growing cancer cell lines.
Analytical biochemistry 2003;320(2):170-8.
2003: Daniel Kushev; Renate Grünert; Nadejda Spassovska; Evgeny Golovinsky; Patrick J Bednarski
Unusual reactivity of cytotoxic cis-dihydrazide Pt(II) complexes in aqueous solution.
Journal of inorganic biochemistry 2003;96(4):469-77.
2001: K Rinke; Renate Grünert; Patrick J Bednarski
New synthetic route to [bis-1,2-(aminomethyl)benzene]dichloroplatinum(II) complexes, screening for cytotoxic activity in cisplatin-sensitive and resistant human cancer cell lines, and reaction with glutathione.
Die Pharmazie 2001;56(10):763-9.