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Grzegorz Grynkiewicz

Research Profile

Chemicals & Drugs

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Mouse

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High Pressure Liquid Chromatography

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Mariusz M Gruza; Piotr Cmoch; Tomasz Giller; Kamil Jatczak; Katarzyna Koziak; Marta Laszcz; Maura Malińska; Krzysztof Woźniak; Bogdan Zagrodzki; Oliwia Zegrocka-Stendel; Grzegorz Grynkiewicz
Preparation, purification and regioselective functionalization of protoescigenin-the main aglycone of escin complex.
Katarzyna Goj; Radosław Kitel; Roman Komor; Aleksandra Rusin; Wiesław Szeja; Grzegorz Grynkiewicz
Synthesis of genistein 2,3-anhydroglycoconjugates -- potential antiproliferative agents.
Anna Adamska; Grzegorz Grynkiewicz; Ewelina Król; Agnieszka B Olejniczak; Wojciech J Szczepek; Bogusław Szewczyk; Krzysztof Zwoliński; Zbigniew J Leśnikowski
Oseltamivir analog with boron cluster modulator.

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All Publications

2013: Mariusz M Gruza; Piotr Cmoch; Tomasz Giller; Kamil Jatczak; Katarzyna Koziak; Marta Laszcz; Maura Malińska; Krzysztof Woźniak; Bogdan Zagrodzki; Oliwia Zegrocka-Stendel; Grzegorz Grynkiewicz
Preparation, purification and regioselective functionalization of protoescigenin-the main aglycone of escin complex.
Molecules (Basel, Switzerland) 2013;18(4):4389-402.
2012: Katarzyna Goj; Radosław Kitel; Roman Komor; Aleksandra Rusin; Wiesław Szeja; Grzegorz Grynkiewicz
Synthesis of genistein 2,3-anhydroglycoconjugates -- potential antiproliferative agents.
Acta poloniae pharmaceutica 2012;69(6):1239-47.
2012: Anna Adamska; Grzegorz Grynkiewicz; Ewelina Król; Agnieszka B Olejniczak; Wojciech J Szczepek; Bogusław Szewczyk; Krzysztof Zwoliński; Zbigniew J Leśnikowski
Oseltamivir analog with boron cluster modulator.
Acta poloniae pharmaceutica 2012;69(6):1218-23.
2012: Teresa Brodniewicz; Grzegorz Grynkiewicz
Plant phenolics as drug leads -- what is missing?
Acta poloniae pharmaceutica 2012;69(6):1203-17.
2012: Karolina Swiatek-Machado; Piotr Swierk; Wiesław Szeja; Slawomir Szymanski; Aleksandra Ellert-Miklaszewska; Izabela Fokt; Grzegorz Grynkiewicz; Bogdan Lesyng; Jakub Mieczkowski; Waldemar Priebe; Stanislaw Skora; Bozena Kaminska
Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells.
Cancer biology & therapy 2012;13(8):657-70.
2012: Anna Kloska; Magdalena Narajczyk; Wiesław Szeja; Magdalena Gabig-Cimińska; Grzegorz Grynkiewicz; Joanna Jakóbkiewicz-Banecka; Grzegorz Węgrzyn
Synthetic genistein derivatives as modulators of glycosaminoglycan storage.
Journal of translational medicine 2012;10():153.
2012: Grzegorz Grynkiewicz; Piotr Ślifirski
Curcumin and curcuminoids in quest for medicinal status.
Acta biochimica Polonica 2012;59(2):201-12.
2011: Graham Lappin; Yoko Shishikura; Roeline Jochemsen; Richard John Weaver; Charlotte Gesson; J Brian Houston; Berend Oosterhuis; Ole J Bjerrum; Grzegorz Grynkiewicz; Jane Alder; Malcolm Rowland; Colin Garner
Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;43(3):141-50.
2011: Aleksandra Rusin; Jadwiga Zawisza-Puchałka; Katarzyna Kujawa; Agnieszka Gogler-Pigłowska; Joanna Wietrzyk; Marta Switalska; Magdalena Głowala-Kosińska; Aleksandra Gruca; Wiesław Szeja; Zdzislaw Krawczyk; Grzegorz Grynkiewicz
Synthetic conjugates of genistein affecting proliferation and mitosis of cancer cells.
Bioorganic & medicinal chemistry 2011;19(1):295-305.
2010: Teresa Brodniewicz; Grzegorz Grynkiewicz
Preclinical drug development.
Acta poloniae pharmaceutica 2010;67(6):578-85.
2010: Jerzy Gubernator; Grzegorz Chwastek; Mariola Korycińska; Maria Stasiuk; Grzegorz Grynkiewicz; Felicitas Lewrick; Regine Süss; Arkadiusz Kozubek
The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2010;146(1):68-75.
2010: Ewelina Krol; Ilona Wandzik; Wieslaw Szeja; Grzegorz Grynkiewicz; Boguslaw Szewczyk
In vitro antiviral activity of some uridine derivatives of 2-deoxy sugars against classical swine fever virus.
Antiviral research 2010;86(2):154-62.
2010: Marcelina Malinowska; Fiona L Wilkinson; Kia J Langford-Smith; Alexander Langford-Smith; Jillian R Brown; Brett E Crawford; marie T vanier; Grzegorz Grynkiewicz; Robert F Wynn; J Ed Wraith; Grzegorz Wegrzyn; Brian W Bigger
Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease.
PloS one 2010;5(12):e14192.
2010: Aleksandra Rusin; Zdzislaw Krawczyk; Grzegorz Grynkiewicz; Agnieszka Gogler; Jadwiga Zawisza-Puchałka; Wiesław Szeja
Synthetic derivatives of genistein, their properties and possible applications.
Acta biochimica Polonica 2010;57(1):23-34.
2009: Aleksandra Rusin; Agnieszka Gogler; Magdalena Głowala-Kosińska; Daria Bochenek; Aleksandra Gruca; Grzegorz Grynkiewicz; Jadwiga Zawisza; Wiesław Szeja; Zdzislaw Krawczyk
Unsaturated genistein disaccharide glycoside as a novel agent affecting microtubules.
Bioorganic & medicinal chemistry letters 2009;19(17):4939-43.
2009: J Maniewska; Grzegorz Grynkiewicz; W Szeja; Andrzej B Hendrich
Interaction of genistein benzyl derivatives with lipid bilayers--fluorescence spectroscopic and calorimetric study.
Bioorganic & medicinal chemistry 2009;17(6):2592-7.
2008: Kamila Sroda; Krystyna Michalak; Jadwiga Maniewska; Grzegorz Grynkiewicz; Wiesław Szeja; Jadwiga Zawisza; Andrzej B Hendrich
Genistein derivatives decrease liposome membrane integrity--calcein release and molecular modeling study.
Biophysical chemistry 2008;138(3):78-82.
2008: Grzegorz Grynkiewicz; Wiesław Szeja; Jerzy Boryski
Synthetic analogs of natural glycosides in drug discovery and development.
Acta poloniae pharmaceutica 2008;65(6):655-76.
2008: Grzegorz Grynkiewicz; Maria Gadzikowska
Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.
Pharmacological reports : PR 2008;60(4):439-63.
2005: Anna Kasprzycka; Wiesław Szeja; Grzegorz Grynkiewicz
Glycosylation of acid sensitive acceptors. Synthesis of (2,3-epoxy-1-propyl) glycosides.
Carbohydrate research 2005;340(15):2443-6.
2005: Barbara Łania-Pietrzak; Krystyna Michalak; Andrzej B Hendrich; Daniela Mosiadz; Grzegorz Grynkiewicz; Noboru Motohashi; Yoshiaki Shirataki
Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.
Life sciences 2005;77(15):1879-91.
2005: Joanna Wietrzyk; Grzegorz Grynkiewicz; Adam Opolski
Phytoestrogens in cancer prevention and therapy--mechanisms of their biological activity.
Anticancer research 2005;25(3c):2357-66.
2005: Leszek Sliwiński; Joanna Folwarczna; Waldemar Janiec; Grzegorz Grynkiewicz; Katarzyna Kuzyk
Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro.
Pharmacological reports : PR 2005;57(3):352-9.
2004: Joanna Wietrzyk; Maria Mazurkiewicz; Janusz A Madej; Stanislaw Dzimira; Grzegorz Grynkiewicz; Czeslaw Radzikowski; Adam Opolski
Genistein alone or combined with cyclophosphamide may stimulate 16/C transplantable mouse mammary cancer growth.
Medical science monitor : international medical journal of experimental and clinical research 2004;10(11):BR414-9.
2004: Czeslaw Radzikowski; Joanna Wietrzyk; Grzegorz Grynkiewicz; Adam Opolski
[Genistein: a soy isoflavone revealing a pleiotropic mechanism of action - clinical implications in the treatment and prevention of cancer].
Postȩpy higieny i medycyny doświadczalnej (Online) 2004;58():128-39.
2004: Hanna Ksycińska; Barbara Sobik; Joanna Popiołkiewicz; Krzysztof Polkowski; Piotr Krzeczyński; Jan Ramza; Wieslaw Pucko; Grzegorz Grynkiewicz
Determination of new derivatives of genistein in culture media by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;799(2):217-31.
2004: Krzysztof Polkowski; Joanna Popiołkiewicz; Piotr Krzeczyński; Jan Ramza; Wiesław Pucko; Oliwia Zegrocka-Stendel; Jerzy Boryski; Janusz S Skierski; Aleksander P Mazurek; Grzegorz Grynkiewicz
Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines.
Cancer letters 2004;203(1):59-69.
2003: Jacek Zielonka; Jerzy Gebicki; Grzegorz Grynkiewicz
Radical scavenging properties of genistein.
Free radical biology & medicine 2003;35(8):958-65.
2003: Piotr Slifirski; Wieslaw Szelejewski; Grzegorz Grynkiewicz; Jerzy Gubernator; Arkadiusz Kozubek
Liposomal formulation of idarubicin.
Acta poloniae pharmaceutica 2003;60(2):138-40.
2003: Ewa Jagiełło-Wójtowicz; Anna Chodkowska; Maria Gadzikowska; Ewa Chojecka-Koryn; Grzegorz Grynkiewicz
Preliminary evaluation of CNS effects of 6-O-substituted chelidonine derivatives.
Acta poloniae pharmaceutica 2003;60(2):133-8.
2002: Maria Gadzikowska; Grzegorz Grynkiewicz
Tropane alkaloids in pharmaceutical and phytochemical analysis.
Acta poloniae pharmaceutica 2002;59(2):149-60.
2001: Maria Gadzikowska; Grzegorz Grynkiewicz
Tropane alkaloids in pharmaceutical and phytochemical analysis.
Acta poloniae pharmaceutica 2001;58(6):481-92.
2001: Joanna Wietrzyk; Janusz Boratynski; Grzegorz Grynkiewicz; A Ryczynski; Czeslaw Radzikowski; Adam Opolski
Antiangiogenic and antitumour effects in vivo of genistein applied alone or combined with cyclophosphamide.
Anticancer research 2001;21(6A):3893-6.
2001: Grzegorz Grynkiewicz; E Chojecka-Koryn; Maria Gadzikowska; Anna Chodkowska; E Jagiełło-Wójtowicz
Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives.
European journal of medicinal chemistry 2001;36(11-12):951-60.