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Zbigniew Grzonka

Research Profile

Genes & Molecular Sequences

Amino Acid Sequences

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Magnetic Resonance Spectroscopy

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Magdalena Rowinska-Zyrek; Daniela Valensin; Lukasz Szyrwiel; Zbigniew Grzonka; Henryk Kozlowski
Specific interactions of Bi(III) with the Cys-Xaa-Cys unit of a peptide sequence.
Aneta Szymańska; Adrianna Radulska; Paulina Czaplewska; Anders Grubb; Zbigniew Grzonka; Sylwia Rodziewicz-Motowidło
Governing the monomer-dimer ratio of human cystatin c by single amino acid substitution in the hinge region.
Teresa Kowalik-Jankowska; Anna Rajewska; Elzbieta Jankowska; Zbigniew Grzonka
Products of Cu(II)-catalyzed oxidation of alpha-synuclein fragments containing M1-D2 and H50 residues in the presence of hydrogen peroxide.

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All Publications

2009: Magdalena Rowinska-Zyrek; Daniela Valensin; Lukasz Szyrwiel; Zbigniew Grzonka; Henryk Kozlowski
Specific interactions of Bi(III) with the Cys-Xaa-Cys unit of a peptide sequence.
Dalton transactions (Cambridge, England : 2003) 2009;(42):9131-40.
2009: Aneta Szymańska; Adrianna Radulska; Paulina Czaplewska; Anders Grubb; Zbigniew Grzonka; Sylwia Rodziewicz-Motowidło
Governing the monomer-dimer ratio of human cystatin c by single amino acid substitution in the hinge region.
Acta biochimica Polonica 2009;56(3):455-63.
2008: Teresa Kowalik-Jankowska; Anna Rajewska; Elzbieta Jankowska; Zbigniew Grzonka
Products of Cu(II)-catalyzed oxidation of alpha-synuclein fragments containing M1-D2 and H50 residues in the presence of hydrogen peroxide.
Dalton transactions (Cambridge, England : 2003) 2008;(6):832-8.
2008: Elena Gaggelli; Zbigniew Grzonka; Henryk Kozłowski; Caterina Migliorini; Elena Molteni; Daniela Valensin; Gianni Valensin
Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment.
Chemical communications (Cambridge, England) 2008;(3):341-3.
2007: Kinga Kulon; Dagmara Woźniak; Katarzyna Wegner; Zbigniew Grzonka; Henryk Kozłowski
Specific interactions of metal ions with Cys-Xaa-Cys unit inserted into the peptide sequence.
Journal of inorganic biochemistry 2007;101(11-12):1699-706.
2007: Paweł Stańczak; Paulina Juszczyk; Zbigniew Grzonka; Henryk Kozłowski
The whole hexapeptide repeats domain from avian PrP displays untypical hallmarks in aspect of the Cu2+ complexes formation.
FEBS letters 2007;581(23):4544-8.
2007: Sylwia Rodziewicz-Motowidło; Paulina Juszczyk; Aleksandra S Kołodziejczyk; Emilia Sikorska; Agnieszka Skwierawska; Marta Oleszczuk; Zbigniew Grzonka
Conformational solution studies of the SDS micelle-bound 11-28 fragment of two Alzheimer's beta-amyloid variants (E22K and A21G) using CD, NMR, and MD techniques.
Biopolymers 2007;87(1):23-39.
2007: Michał Manturewicz; Zbigniew Grzonka; Lenka Borovicková; Jirina Slaninová
Oxytocin analogues with amide groups substituted by tetrazole groups in position 4, 5 or 9.
Acta biochimica Polonica 2007;54(4):805-11.
2006: Teresa Kowalik-Jankowska; Anna Rajewska; Elzbieta Jankowska; Zbigniew Grzonka
Copper(II) binding by fragments of alpha-synuclein containing M1-D2- and -H50-residues; a combined potentiometric and spectroscopic study.
Dalton transactions (Cambridge, England : 2003) 2006;(42):5068-76.
2006: Pawel Stanczak; Daniela Valensin; Elena Porciatti; Elzbieta Jankowska; Zbigniew Grzonka; Elena Molteni; Elena Gaggelli; Gianni Valensin; Henryk Kozlowski
Tandem repeat-like domain of "similar to prion protein" (StPrP) of Japanese pufferfish binds Cu(II) as effectively as the mammalian protein.
Biochemistry 2006;45(40):12227-39.
2006: Teresa Kowalik-Jankowska; Anna Rajewska; Elzbieta Jankowska; Kornelia Wiśniewska; Zbigniew Grzonka
Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen peroxide.
Journal of inorganic biochemistry 2006;100(10):1623-31.
2006: Sylwia Rodziewicz-Motowidło; Maria Wahlbom; Xin Wang; Justyna Lagiewka; Robert Janowski; Mariusz Jaskólski; Anders Grubb; Zbigniew Grzonka
Checking the conformational stability of cystatin C and its L68Q variant by molecular dynamics studies: why is the L68Q variant amyloidogenic?
Journal of structural biology 2006;154(1):68-78.
2005: Ewa Wieczerzak; Elzbieta Jankowska; S Rodziewicz-Motowidło; A Giełdoń; J Lagiewka; Zbigniew Grzonka; Magnus Abrahamson; Anders Grubb; D Brömme
Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B.
The journal of peptide research : official journal of the American Peptide Society 2005;66 Suppl 1():1-11.
2005: Teresa Kowalik-Jankowska; Anna Rajewska; Kornelia Wiśniewska; Zbigniew Grzonka; Julia Jezierska
Coordination abilities of N-terminal fragments of alpha-synuclein towards copper(II) ions: a combined potentiometric and spectroscopic study.
Journal of inorganic biochemistry 2005;99(12):2282-91.
2005: Pawel Stanczak; Daniela Valensin; Paulina Juszczyk; Zbigniew Grzonka; Caterina Migliorini; Elena Molteni; Gianni Valensin; Elena Gaggelli; Henryk Kozlowski
Structure and stability of the CuII complexes with tandem repeats of the chicken prion.
Biochemistry 2005;44(39):12940-54.
2005: Paweł Stańczak; Daniela Valensin; Paulina Juszczyk; Zbigniew Grzonka; Gianni Valensin; Francesca Bernardi; Elena Molteni; Elena Gaggelli; Henryk Kozłowski
Fine tuning the structure of the Cu2+ complex with the prion protein chicken repeat by proline isomerization.
Chemical communications (Cambridge, England) 2005;(26):3298-300.
2005: Roman Kaliszan; Tomasz Baczek; Anna Cimochowska; Paulina Juszczyk; Kornelia Wiśniewska; Zbigniew Grzonka
Prediction of high-performance liquid chromatography retention of peptides with the use of quantitative structure-retention relationships.
Proteomics 2005;5(2):409-15.
2005: Paulina Juszczyk; Aleksandra S Kołodziejczyk; Zbigniew Grzonka
Circular dichroism and aggregation studies of amyloid beta (11-8) fragment and its variants.
Acta biochimica Polonica 2005;52(2):425-31.
2005: Tomasz Baczek; Michał P Marszałł; Roman Kaliszan; Lukasz Walijewski; Wanda Makowiecka; Barbara Sparzak; Zbigniew Grzonka; Kornelia Wiśniewska; Paulina Juszczyk
Behavior of peptides and computer-assisted optimization of peptides separations in a normal-phase thin-layer chromatography system with and without the addition of ionic liquid in the eluent.
Biomedical chromatography : BMC 2005;19(1):1-8.
2004: Robert Janowski; Maciej Kozak; Elzbieta Jankowska; Zbigniew Grzonka; Mariusz Jaskólski
Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor.
The journal of peptide research : official journal of the American Peptide Society 2004;64(4):141-50.
2004: Elzbieta Jankowska; Wieslaw Wiczk; Zbigniew Grzonka
Thermal and guanidine hydrochloride-induced denaturation of human cystatin C.
European biophysics journal : EBJ 2004;33(5):454-61.
2004: Pawel Stańczak; Marek Łuczkowski; Paulina Juszczyk; Zbigniew Grzonka; Henryk Kozłowski
Interactions of Cu2+ ions with chicken prion tandem repeats.
Dalton transactions (Cambridge, England : 2003) 2004;(14):2102-7.
2004: Maria Nilsson; Xin Wang; Sylwia Rodziewicz-Motowidlo; Robert Janowski; Veronica Lindström; Patrik Onnerfjord; Gunilla Westermark; Zbigniew Grzonka; Mariusz Jaskolski; Anders Grubb
Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C.
The Journal of biological chemistry 2004;279(23):24236-45.
2004: Krystyna Stachowiak; Sylwia Rodziewicz-Motowidło; Renata Sosnowska; Franciszek Kasprzykowski; Leszek Łankiewicz; Anders Grubb; Zbigniew Grzonka
Effect of antisense peptide binding on the dimerization of human cystatin C--gel electrophoresis and molecular modeling studies.
Acta biochimica Polonica 2004;51(1):153-60.
2002: Ewa Wieczerzak; Piotr Drabik; Leszek Łankiewicz; Stanisław Ołdziej; Zbigniew Grzonka; Magnus Abrahamson; Anders Grubb; Dieter Brömme
Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases.
Journal of medicinal chemistry 2002;45(19):4202-11.
2002: Sylwia Rodziewicz-Motowidło; Igor Zhukov; Franciszek Kasprzykowski; Zbigniew Grzonka; Jerzy Ciarkowski; Jacek Wójcik
Conformational solution studies of (Sar7)desamino- and (MeAla7)desamino-vasopressin analogues using NMR spectroscopy.
Journal of peptide science : an official publication of the European Peptide Society 2002;8(7):347-64.
2002: Elzbieta Jankowska; Miroslaw Gilski; Mariusz Jaskólski; Zbigniew Grzonka; Leszek Łankiewicz
O-Benzyl-N-tert-butoxycarbonyl-N-methyl-L-tyrosine.
Acta crystallographica. Section C, Crystal structure communications 2002;58(Pt 6):o353-4.
2001: Robert Janowski; Maciej Kozak; Elzbieta Jankowska; Zbigniew Grzonka; Anders Grubb; Magnus Abrahamson; Mariusz Jaskolski
Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping.
Nature structural biology 2001;8(4):316-20.
2001: Zbigniew Grzonka; Elzbieta Jankowska; Franciszek Kasprzykowski; Regina Kasprzykowska; Leszek Lankiewicz; Wieslaw Wiczk; Ewa Wieczerzak; Jerzy Ciarkowski; Piotr Drabik; Robert Janowski; Maciej Kozak; Mariusz Jaskólski; Anders Grubb
Structural studies of cysteine proteases and their inhibitors.
Acta biochimica Polonica 2001;48(1):1-20.
2000: L Johansson; Anders Grubb; Magnus Abrahamson; Franciszek Kasprzykowski; Regina Kasprzykowska; Zbigniew Grzonka; Ulf H Lerner
A peptidyl derivative structurally based on the inhibitory center of cystatin C inhibits bone resorption in vitro.
Bone 2000;26(5):451-9.
2000: M Jasionowski; Zbigniew Grzonka; Leszek Lankiewicz
[G protein-coupled receptors (GPCR), ligand-receptor interaction studies].
Postepy biochemii 2000;46(1):60-72.
1999: Maciej Kozak; Elzbieta Jankowska; Robert Janowski; Zbigniew Grzonka; Anders Grubb; Marcia Alvarez-Fernandez; Magnus Abrahamson; Mariusz Jaskolski
Expression of a selenomethionyl derivative and preliminary crystallographic studies of human cystatin C.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 11):1939-42.
1999: Cezary Czaplewski; Zbigniew Grzonka; Mariusz Jaskólski; Franciszek Kasprzykowski; Maciej Kozak; E Politowska; Jerzy Ciarkowski
Binding modes of a new epoxysuccinyl-peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity?
Biochimica et biophysica acta 1999;1431(2):290-305.
1998: YJ Cao; Elzbieta Kojro; M Jasionowski; Leszek Lankiewicz; Zbigniew Grzonka; Falk Fahrenholz
Identification of binding domains of pituitary adenylate cyclase activating polypeptide (PACAP) for its type 1 receptor by photoaffinity labeling.
Annals of the New York Academy of Sciences 1998;865():82-91.
1997: Maciej Kozak; E Kozian; Zbigniew Grzonka; Mariusz Jaskólski
Crystallization and preliminary crystallographic studies of a new crystal form of papain from Carica papaya.
Acta biochimica Polonica 1997;44(3):601-5.
1997: Wieslaw Wiczk; Leszek Lankiewicz; Franciszek Kasprzykowski; S Ołdziej; Henryk Szmacinski; Joseph R Lakowicz; Zbigniew Grzonka
Fluorescence study of neurohypophyseal hormones and their analogues. Distance distributions in a series of arginine-vasopressin analogues.
European biophysics journal : EBJ 1997;26(2):183-93.
1996: Gianni Valensin; A Maccotta; Elena Gaggelli; Zbigniew Grzonka; Franciszek Kasprzykowski; H Kozlowski
1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide.
European journal of biochemistry / FEBS 1996;240(1):118-24.
1996: Adam Liwo; A Tempczyk; S Ołdziej; MD Shenderovich; V J Hruby; S Talluri; Jerzy Ciarkowski; Franciszek Kasprzykowski; Leszek Lankiewicz; Zbigniew Grzonka
Exploration of the conformational space of oxytocin and arginine-vasopressin using the electrostatically driven Monte Carlo and molecular dynamics methods.
Biopolymers 1996;38(2):157-75.
1995: Stanislaw Oldziej; Jerzy Ciarkowski; Adam Liwo; MD Shenderovich; Zbigniew Grzonka
Conformational aspects of differences in requirements for oxytocin and vasopressin receptors.
Journal of receptor and signal transduction research 1995;15(1-4):703-13.
1992: Maurice Manning; J Przybylski; Zbigniew Grzonka; E Nawrocka; Bernard Lammek; A Misicka; Ling Ling Cheng; WY Chan; Nga Ching Wo; William H Sawyer
Potent V2/V1a vasopressin antagonists with C-terminal ethylenediamine-linked retro-amino acids.
Journal of medicinal chemistry 1992;35(21):3895-904.
1992: B Okopień; L Lubkowska; Zbigniew Grzonka; Henryk I Trzeciak
Vascular action of natural vasopressin-like peptides in isolated rat tail artery.
Polish journal of pharmacology and pharmacy 1992;44(2):173-7.
1992: M Tarnowska; Stanislaw Oldziej; Adam Liwo; Zbigniew Grzonka; Edward Borowski
Investigation of the inhibition pathway of glucosamine synthase by N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid by semiempirical quantum mechanical and molecular mechanics methods.
European biophysics journal : EBJ 1992;21(4):273-80.
1992: M Tarnowska; Stanislaw Oldziej; Adam Liwo; P Kania; Franciszek Kasprzykowski; Zbigniew Grzonka
MNDO study of the mechanism of the inhibition of cysteine proteinases by diazomethyl ketones.
European biophysics journal : EBJ 1992;21(3):217-22.
1991: J M Schmidt; O Ohlenschläger; Heinz Rüterjans; Zbigniew Grzonka; Elzbieta Kojro; Imre Pavo; Falk Fahrenholz
Conformation of [8-arginine]vasopressin and V1 antagonists in dimethyl sulfoxide solution derived from two-dimensional NMR spectroscopy and molecular dynamics simulation.
European journal of biochemistry / FEBS 1991;201(2):355-71.
1991: Zbigniew Grzonka; Franciszek Kasprzykowski; L Lubkowska; K Darłak; T A Hahn; Arno F Spatola
In vitro degradation of some arginine-vasopressin analogs by homogenates of rat kidney, liver and serum.
Peptide research 1991;4(5):270-4.
1991: H Miszta; Franciszek Kasprzykowski; Zbigniew Grzonka; Leszek Lankiewicz
Effect of vasopressin, oxytocin and LHRH on the proliferation and metabolism of rat bone marrow stromal cells in culture.
Endocrine regulations 1991;25(3):177-80.
1990: Anders Grubb; Magnus Abrahamson; Isleifur Olafsson; J Trojnar; R Kasprzykowska; Franciszek Kasprzykowski; Zbigniew Grzonka
Synthesis of cysteine proteinase inhibitors structurally based on the proteinase interacting N-terminal region of human cystatin C.
Biological chemistry Hoppe-Seyler 1990;371 Suppl():137-44.
1989: Adam Liwo; A Tempczyk; Zbigniew Grzonka
Theoretical studies of the mechanism of the action of the neurohypophyseal hormones. I. Molecular electrostatic potential (MEP) and molecular electrostatic field (MEF) maps of some vasopressin analogues.
Journal of computer-aided molecular design 1989;3(3):261-84.
1989: Adam Liwo; A Tempczyk; Zbigniew Grzonka
Molecular mechanics calculations on deaminooxytocin and on deamino-arginine-vasopressin and its analogues.
Journal of computer-aided molecular design 1989;2(4):281-309.
1988: K Darlak; D E Benovitz; Arno F Spatola; Zbigniew Grzonka
Dermorphin analogs: resistance to in vitro enzymatic degradation is not always increased by additional D-amino acid substitutions.
Biochemical and biophysical research communications 1988;156(1):125-30.
1988: Zbigniew Grzonka; E Gwizdała; Franciszek Kasprzykowski; Leszek Lankiewicz
Circular dichroism studies of some arginine-vasopressin analogues.
Biophysical chemistry 1988;31(1-2):87-100.
1987: Elzbieta Kojro; I Willhardt; A Römbach; Zbigniew Grzonka; P Hermann
Tetrazole analogs of amino acids as constituents of modifiers of carboxypeptidase A catalysis.
FEBS letters 1987;212(1):83-6.
1986: Falk Fahrenholz; Elzbieta Kojro; M Müller; R Boer; R Löhr; Zbigniew Grzonka
Iodinated photoreactive vasopressin antagonists: labelling of hepatic vasopressin receptor subunits.
European journal of biochemistry / FEBS 1986;161(2):321-8.
1986: Zbigniew Grzonka; Franciszek Kasprzykowski; Elzbieta Kojro; K Darlak; P Melin; Falk Fahrenholz; P Crause; R Boer
Arginine-vasopressin analogues with high antidiuretic/vasopressor selectivity. Synthesis, biological activity, and receptor binding affinity of arginine-vasopressin analogues with substitutions in positions 1, 2, 4, 7, and 8.
Journal of medicinal chemistry 1986;29(1):96-9.
1985: F Toma; Vincent Dive; Serge Fermandjian; K Darlak; Zbigniew Grzonka
Preferred solution and calculated conformations of dermorphin and analysis of structure-conformation-activity relationships in the series [Alan]-dermorphin.
Biopolymers 1985;24(12):2417-30.
1984: K Darłak; Zbigniew Grzonka; P Krzaścik; P Janicki; S W Gumułka
Structure-activity studies of dermorphin. The role of side chains of amino acid residues on the biological activity of dermorphin.
Peptides 1984;5(4):687-9.
1984: Falk Fahrenholz; R Boer; P Crause; G Fritzsch; Zbigniew Grzonka
Interactions of vasopressin agonists and antagonists with membrane receptors.
European journal of pharmacology 1984;100(1):47-58.
1984: D Gazis; I L Schwartz; Bernard Lammek; Zbigniew Grzonka
Influence of sarcosine or N-methylalanine in position 7 on the antagonistic properties of [1-deaminopenicillamine]- and [1-(beta-mercapto-beta, beta-cyclopentylmethylene-propionic acid)]-vasopressin.
International journal of peptide and protein research 1984;23(1):78-83.
1983: Zbigniew Grzonka; Bernard Lammek; D Gazis; I L Schwartz
Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin.
Journal of medicinal chemistry 1983;26(12):1786-7.
1983: K Darłak; Zbigniew Grzonka; P Janicki; A Członkowski; S W Gumułka
Structure-activity studies of dermorphin. Synthesis and some pharmacological data of dermorphin and its 1-substituted analogues.
Journal of medicinal chemistry 1983;26(10):1445-7.
1983: Zbigniew Grzonka; Bernard Lammek; Franciszek Kasprzykowski; D Gazis; I L Schwartz
Synthesis and some pharmacological properties of oxytocin and vasopressin analogues with sarcosine or N-methyl-L-alanine in position 7.
Journal of medicinal chemistry 1983;26(4):555-9.