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Michael Gschwendt

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Chemicals & Drugs

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Mouse

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Phosphorylation

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TOP 3
Michael Gschwendt; Luise Stempka
Expression and purification of protein kinase Cdelta from bacteria.
Etienne Meylan; Fabio Martinon; Margot Thome; Michael Gschwendt; Jürg Tschopp
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.
C Bhr; A Rohwer; Luise Stempka; Gabriele Rincke; Friedrich Marks; Michael Gschwendt
DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis.

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All Publications

2003: Michael Gschwendt; Luise Stempka
Expression and purification of protein kinase Cdelta from bacteria.
Methods in molecular biology (Clifton, N.J.) 2003;233():35-42.
2002: Etienne Meylan; Fabio Martinon; Margot Thome; Michael Gschwendt; Jürg Tschopp
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.
EMBO reports 2002;3(12):1201-8.
2000: C Bhr; A Rohwer; Luise Stempka; Gabriele Rincke; Friedrich Marks; Michael Gschwendt
DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis.
The Journal of biological chemistry 2000;275(46):36350-7.
2000: Jerzy Ostrowski; Daniel S Schullery; Oleg Denisenko; Yuji Higaki; J Watts; Ruedi Aebersold; Luise Stempka; Michael Gschwendt; Karol Bomsztyk
Role of tyrosine phosphorylation in the regulation of the interaction of heterogenous nuclear ribonucleoprotein K protein with its protein and RNA partners.
The Journal of biological chemistry 2000;275(5):3619-28.
1999: S Häussermann; W Kittstein; Gabriele Rincke; FJ Johannes; Friedrich Marks; Michael Gschwendt
Proteolytic cleavage of protein kinase Cmu upon induction of apoptosis in U937 cells.
FEBS letters 1999;462(3):442-6.
1999: A Rohwer; W Kittstein; Friedrich Marks; Michael Gschwendt
Cloning, expression and characterization of an A6-related protein.
European journal of biochemistry / FEBS 1999;263(2):518-25.
1999: Daniel S Schullery; Jerzy Ostrowski; Oleg Denisenko; Luise Stempka; Maria Shnyreva; Hideaki Suzuki; Michael Gschwendt; Karol Bomsztyk
Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein.
The Journal of biological chemistry 1999;274(21):15101-9.
1999: Luise Stempka; Martina Schnölzer; S Radke; Gabriele Rincke; Friedrich Marks; Michael Gschwendt
Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643.
The Journal of biological chemistry 1999;274(13):8886-92.
1999: Michael Gschwendt
Protein kinase C delta.
European journal of biochemistry / FEBS 1999;259(3):555-64.
1998: U von Reyher; Jörn Sträter; W Kittstein; Michael Gschwendt; P H Krammer; Peter Möller
Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.
Cancer research 1998;58(3):526-34.
1998: Michael Gschwendt; W Kittstein; FJ Johannes
Differential effects of suramin on protein kinase C isoenzymes. A novel tool for discriminating protein kinase C activities.
FEBS letters 1998;421(2):165-8.
1997: Michael Gschwendt; FJ Johannes; W Kittstein; Friedrich Marks
Regulation of protein kinase Cmu by basic peptides and heparin. Putative role of an acidic domain in the activation of the kinase.
The Journal of biological chemistry 1997;272(33):20742-6.
1997: Luise Stempka; Anne Girod; H J Müller; Gabriele Rincke; Friedrich Marks; Michael Gschwendt; Dirk Bossemeyer
Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form.
The Journal of biological chemistry 1997;272(10):6805-11.
1996: J Rennecke; F J Johannes; Karl Hartmut Richter; W Kittstein; Friedrich Marks; Michael Gschwendt
Immunological demonstration of protein kinase C mu in murine tissues and various cell lines. Differential recognition of phosphorylated forms and lack of down-regulation upon 12-O-tetradecanoylphorphol-13-acetate treatment of cells.
European journal of biochemistry / FEBS 1996;242(2):428-32.
1996: Michael Gschwendt; S Dieterich; J Rennecke; W Kittstein; H J Mueller; F J Johannes
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
FEBS letters 1996;392(2):77-80.
1995: K Kielbassa; H J Müller; H E Meyer; Friedrich Marks; Michael Gschwendt
Protein kinase C delta-specific phosphorylation of the elongation factor eEF-alpha and an eEF-1 alpha peptide at threonine 431.
The Journal of biological chemistry 1995;270(11):6156-62.
1995: Michael Gschwendt; W Kittstein; K Kielbassa; Friedrich Marks
Protein kinase C delta accepts GTP for autophosphorylation.
Biochemical and biophysical research communications 1995;206(2):614-20.
1995: Michael Gschwendt; Gerhard Fürstenberger; H Leibersperger; W Kittstein; D Lindner; C Rudolph; H Barth; J Kleinschroth; D Marmé; C Schächtele
Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo.
Carcinogenesis 1995;16(1):107-11.
1994: R Zang; H J Müller; K Kielbassa; Friedrich Marks; Michael Gschwendt
Partial purification of a type eta protein kinase C from murine brain: separation from other protein kinase C isoenzymes and characterization.
The Biochemical journal 1994;304 ( Pt 2)():641-7.
1994: Michael Gschwendt; K Kielbassa; W Kittstein; Friedrich Marks
Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta.
FEBS letters 1994;347(1):85-9.
1994: Michael Gschwendt; H J Müller; K Kielbassa; R Zang; W Kittstein; Gabriele Rincke; Friedrich Marks
Rottlerin, a novel protein kinase inhibitor.
Biochemical and biophysical research communications 1994;199(1):93-8.
1994: Michael Gschwendt; W Kittstein; Friedrich Marks
Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine.
FEBS letters 1994;338(1):85-8.
1993: Michael Gschwendt; W Kittstein; Friedrich Marks
Protein kinase C forms a complex with and phosphorylates the GTPase activating protein GAP: phosphorylation by PKC is dependent on tyrosine phosphorylation of GAP and/or a GAP-associated protein.
Biochemical and biophysical research communications 1993;194(1):571-6.
1992: Michael Gschwendt; W Kittstein; D Lindner; Friedrich Marks
Differential inhibition by staurosporine of phorbol ester, bryostatin and okadaic acid effects on mouse skin.
Cancer letters 1992;66(2):139-46.
1992: Michael Gschwendt; H Leibersperger; W Kittstein; Friedrich Marks
Protein kinase C zeta and eta in murine epidermis. TPA induces down-regulation of PKC eta but not PKC zeta.
FEBS letters 1992;307(2):151-5.
1992: D Lindner; Michael Gschwendt; Friedrich Marks
Phorbol ester-induced down-regulation of the 80-kDa myristoylated alanine-rich C-kinase substrate-related protein in Swiss 3T3 fibroblasts. Inhibition by staurosporine.
The Journal of biological chemistry 1992;267(1):24-6.
1991: Michael Gschwendt; H Leibersperger; Gabriele Rincke; Friedrich Marks
Immunological demonstration of epsilon PKC. Murine tissue distribution, ontogeny, cellular localization and translocation.
FEBS letters 1991;290(1-2):115-8.
1991: H Leibersperger; Michael Gschwendt; M Gernold; Friedrich Marks
Immunological demonstration of a calcium-unresponsive protein kinase C of the delta-type in different species and murine tissues. Predominance in epidermis.
The Journal of biological chemistry 1991;266(22):14778-84.
1991: D Lindner; Michael Gschwendt; Friedrich Marks
Down-regulation of protein kinase C in Swiss 3T3 fibroblasts is independent of its phosphorylating activity.
Biochemical and biophysical research communications 1991;176(3):1227-31.
1991: Michael Gschwendt; W Kittstein; F Marks
Protein kinase C activation by phorbol esters: do cysteine-rich regions and pseudosubstrate motifs play a role?
Trends in biochemical sciences 1991;16(5):167-9.
1990: H Leibersperger; Michael Gschwendt; Friedrich Marks
Purification and characterization of a calcium-unresponsive, phorbol ester/phospholipid-activated protein kinase from porcine spleen.
The Journal of biological chemistry 1990;265(27):16108-15.
1989: Michael Gschwendt; H Leibersperger; Friedrich Marks
Differentiative action of K252a on protein kinase C and a calcium-unresponsive, phorbol ester/phospholipid-activated protein kinase.
Biochemical and biophysical research communications 1989;164(3):974-82.
1989: Michael Gschwendt; W Kittstein; G Mieskes; Friedrich Marks
A type 2A protein phosphatase dephosphorylates the elongation factor 2 and is stimulated by the phorbol ester TPA in mouse epidermis in vivo.
FEBS letters 1989;257(2):357-60.
1989: Michael Gschwendt; W Kittstein; Friedrich Marks
Cyclosporine A suppresses an early process in phorbol ester action.
Cancer letters 1989;46(2):113-5.
1989: Michael Gschwendt; W Kittstein; F Horn; H Leibersperger; Friedrich Marks
A phorbol ester and phospholipid-activated, calcium-unresponsive protein kinase in mouse epidermis: characterization and separation from protein kinase C.
Journal of cellular biochemistry 1989;40(3):295-307.
1989: Michael Gschwendt; W Kittstein; Friedrich Marks
The immunosuppressant FK-506, like cyclosporins and didemnin B, inhibits calmodulin-dependent phosphorylation of the elongation factor 2 in vitro and biological effects of the phorbol ester TPA on mouse skin in vivo.
Immunobiology 1989;179(1):1-7.
1988: Michael Gschwendt; W Kittstein; F Marks
Sequence similarity between cyclophilin and elongation factor 2.
The Biochemical journal 1988;256(3):1061.
1988: Michael Gschwendt; W Kittstein; Friedrich Marks
Effect of tumor promoting phorbol ester TPA on epidermal protein synthesis: stimulation of an elongation factor 2 phosphatase activity by TPA in vivo.
Biochemical and biophysical research communications 1988;153(3):1129-35.
1988: Michael Gschwendt; Gerhard Fürstenberger; S Rose-John; M Rogers; W Kittstein; George R Pettit; C L Herald; Friedrich Marks
Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro.
Carcinogenesis 1988;9(4):555-62.
1988: Michael Gschwendt; W Kittstein; Friedrich Marks
The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
Biochemical and biophysical research communications 1988;150(2):545-51.
1988: Michael Gschwendt; W Kittstein; Friedrich Marks
Ciclosporin inhibits phorbol-ester-induced hyperplastic transformation and tumor promotion in mouse skin probably by suppression of Ca2+/calmodulin-dependent processes such as phosphorylation of elongation factor 2.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1988;1(2):84-92.
1987: Michael Gschwendt; W Kittstein; F Marks
Didemnin B inhibits biological effects of tumor promoting phorbol esters on mouse skin, as well as phosphorylation of a 100 kD protein in mouse epidermis cytosol.
Cancer letters 1987;34(2):187-91.
1987: Michael Gschwendt; W Kittstein; F Marks
Cyclosporin A inhibits phorbol ester-induced cellular proliferation and tumor promotion as well as phosphorylation of a 100-kd protein in mouse epidermis.
Carcinogenesis 1987;8(2):203-7.
1986: Michael Gschwendt; W Kittstein; F Marks
A novel type of phorbol ester-dependent protein phosphorylation in the particulate fraction of mouse epidermis.
Biochemical and biophysical research communications 1986;137(2):766-74.
1986: Michael Gschwendt; Gerhard Fürstenberger; W Kittstein; E Besemfelder; W E Hull; H Hagedorn; H J Opferkuch; Friedrich Marks
Generation of the arachidonic acid metabolite 8-HETE by extracts of mouse skin treated with phorbol ester in vivo; identification by 1H-n.m.r. and GC-MS spectroscopy.
Carcinogenesis 1986;7(3):449-55.
1985: Michael Gschwendt; W Kittstein; F Horn; F Marks
Cyclosporin A inhibits biological effects of tumor promoting phorbol esters.
Biochemical and biophysical research communications 1985;126(1):327-32.
1984: Michael Gschwendt; W Kittstein; G Fürstenberger; F Marks
The mouse ear edema: a quantitatively evaluable assay for tumor promoting compounds and for inhibitors of tumor promotion.
Cancer letters 1984;25(2):177-85.
1984: Michael Gschwendt; F Horn; W Kittstein; Gerhard Fürstenberger; E Besemfelder; Friedrich Marks
Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds.
Biochemical and biophysical research communications 1984;124(1):63-8.
1984: Michael Gschwendt; W Kittstein; F Marks
Stimulation of alkaline phosphatase activity in mouse epidermis by tumor promoters.
Cancer letters 1984;22(2):219-25.
1983: Michael Gschwendt; F Horn; W Kittstein; F Marks
Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.
Biochemical and biophysical research communications 1983;117(2):444-7.
1983: Michael Gschwendt; F Horn; W Kittstein; G Fürstenberger; F Marks
Soluble phorbol ester binding sites and phospholipid- and calcium-dependent protein kinase activity in cytosol of chick oviduct.
FEBS letters 1983;162(1):147-50.
1983: Michael Gschwendt; W Kittstein
Soluble phorbol ester binding sites in cytosol of chick liver and brain--activation by phosphatidylserine.
Cancer letters 1983;19(2):159-64.
1983: Michael Gschwendt; Gabriele Rincke; T Schuster
Inhibition of the estrogen-induced synthesis of vitellogenin mRNA in chick liver by tamoxifen.
Biochemical and biophysical research communications 1983;112(2):425-30.
1983: Michael Gschwendt; W Kittstein
Disactivation and inhibition of activation of the estrogen receptor from chick oviduct by periodate - comparison with the effects of molybdate and o-phenanthroline.
Journal of receptor research 1983;3(3):377-92.
1982: Michael Gschwendt; Gabriele Rincke; T Schuster
The estrogen-induced vitellogenin synthesis in chicken liver after estrogen withdrawal or antiestrogen treatment.
Molecular and cellular endocrinology 1982;26(1-2):231-42.
1980: Michael Gschwendt; W Kittstein
Transformation of the estrogen-receptor complex from chick oviduct in 2 steps.
Molecular and cellular endocrinology 1980;20(3):251-60.