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Ting-Lei Gu

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Taro Hitosugi; Peng Jin; Hee-Bum Kang; Sumin Kang; Yibin Kang; Hanna J Khoury; Fadlo R Khuri; Gary Leroy; Sagar Lonial; Jae-Ho Seo; Changliang Shan; Dong M Shin; Yi Wang; Jianxin Xie; Liang Zhang; Lu Zhou; Masa Alečković; Martha L Arellano; Titus Boggon; Georgia Z Chen; Shannon Elf; Jun Fan; Weimin Gong; Ting-Lei Gu; Chuan He; Jing Chen
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Victoria M Rimkunas; Matthew R Silver; Xinmin Zhou; Katherine E Crosby; Ting-Lei Gu; Yerong Hu; Meghan E Kelly; Daiqiang Li; Jennifer S Mack; Herbert Haack
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion.
Hong Ren; Jian-Min Ren; John Rush; Zhi-Ping Tan; Yi-Feng Yang; Yi Zhang; Xin-Min Zhou; Xin Zhu; Katherine Crosby; Ting-Lei Gu; Herbert Haack; Gregory Innocenti; Albrecht Moritz; Sean Beausoleil; Michael J Comb
Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.

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All Publications

2013: Taro Hitosugi; Peng Jin; Hee-Bum Kang; Sumin Kang; Yibin Kang; Hanna J Khoury; Fadlo R Khuri; Gary Leroy; Sagar Lonial; Jae-Ho Seo; Changliang Shan; Dong M Shin; Yi Wang; Jianxin Xie; Liang Zhang; Lu Zhou; Masa Alečković; Martha L Arellano; Titus Boggon; Georgia Z Chen; Shannon Elf; Jun Fan; Weimin Gong; Ting-Lei Gu; Chuan He; Jing Chen
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Nature communications 2013;4():1790.
2012: Victoria M Rimkunas; Matthew R Silver; Xinmin Zhou; Katherine E Crosby; Ting-Lei Gu; Yerong Hu; Meghan E Kelly; Daiqiang Li; Jennifer S Mack; Herbert Haack
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(16):4449-57.
2012: Hong Ren; Jian-Min Ren; John Rush; Zhi-Ping Tan; Yi-Feng Yang; Yi Zhang; Xin-Min Zhou; Xin Zhu; Katherine Crosby; Ting-Lei Gu; Herbert Haack; Gregory Innocenti; Albrecht Moritz; Sean Beausoleil; Michael J Comb
Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer.
Cancer research 2012;72(13):3312-23.
2012: Hong-ling Peng; Chong-wen Dai; Ting-Lei Gu; Guang-sen Zhang; Jian Yu
[Screen of phosphopeptide specific for acute leukemia].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2012;33(3):163-8.
2011: Jun Fan; Qingyuan Ge; Ting-Lei Gu; Taro Hitosugi; Sumin Kang; Fadlo R Khuri; Sagar Lonial; Roberto D Polakiewicz; Jianxin Xie; Titus Boggon; Georgia Z Chen; Tae-Wook Chung; Jing Chen
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
Molecular and cellular biology 2011;31(24):4938-50.
2011: Chiara Pighi; Ting-Lei Gu; Irene Dalai; Stefano Barbi; Claudia Parolini; Anna Bertolaso; Serena Pedron; Alice Parisi; Jianmin Ren; Daniela Cecconi; Marco Chilosi; Fabio Menestrina; Alberto Zamò
Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling.
Cellular oncology (Dordrecht) 2011;34(2):141-53.
2011: Ting-Lei Gu; Julie Nardone; Yi Wang; Marc Loriaux; Judit Villén; Sean Beausoleil; Meghan Tucker; Jon Kornhauser; Jianmin Ren; Joan MacNeill; Steven P Gygi; Brian J Druker; Michael C Heinrich; John Rush; Roberto D Polakiewicz
Survey of activated FLT3 signaling in leukemia.
PloS one 2011;6(4):e19169.
2011: Ting-Lei Gu; Xiaxing Deng; Feizhou Huang; Meghan Tucker; Katherine Crosby; Victoria Rimkunas; Yi Wang; Gang Deng; Lei Zhu; Zhiping Tan; Yerong Hu; Chunlin Wu; Julie Nardone; Joan MacNeill; Jianmin Ren; Cynthia Reeves; Gregory Innocenti; Brett Norris; Jin Yuan; Jian Yu; Herbert Haack; Baiyong Shen; Chenghong Peng; Hongwei Li; Xinmin Zhou; Xunyang Liu; John Rush; Michael J Comb
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma.
PloS one 2011;6(1):e15640.
2010: Julian Carretero; Takeshi Shimamura; Klarisa Rikova; Autumn L Jackson; Matthew D Wilkerson; Christa L Borgman; Matthew S Buttarazzi; Benjamin A Sanofsky; Kate McNamara; Kathleyn A Brandstetter; Zandra E Walton; Ting-Lei Gu; Jeffrey C Silva; Katherine Crosby; Geoffrey I Shapiro; Sauveur-Michel Maira; Hongbin Ji; Diego H Castrillon; Carla F Kim; Carlos García-Echeverría; Nabeel Bardeesy; Norman E Sharpless; Neil D Hayes; William Y Kim; Jeffrey A Engelman; Kwok-Kin Wong
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Cancer cell 2010;17(6):547-59.
2010: Sumin Kang; Shannon Elf; Katherine Lythgoe; Taro Hitosugi; Jack Taunton; Wei Zhou; Li Xiong; Dongsheng Wang; Susan Muller; Songqing Fan; Shi-Yong Sun; Adam I Marcus; Ting-Lei Gu; Roberto D Polakiewicz; Zhuo Georgia Chen; Fadlo R Khuri; Dong M Shin; Jing Chen
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
The Journal of clinical investigation 2010;120(4):1165-77.
2010: Melodie L Knowlton; Laura M Selfors; Carolyn N Wrobel; Ting-Lei Gu; Bryan A Ballif; Steven P Gygi; Roberto Polakiewicz; Joan S Brugge
Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.
PloS one 2010;5(10):e13587.
2009: Chitta Kasyapa; Ting-Lei Gu; Lalitha Nagarajan; Lalitha Natarajan; Roberto Polakiewicz; John Kenneth Cowell
Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS.
Proteomics 2009;9(16):3979-88.
2009: Jian Yu; Susan Kane; Jiong Wu; Elisa Benedettini; Daiqiang Li; Cynthia Reeves; Gregory Innocenti; Randy Wetzel; Katherine Crosby; Alison Becker; Michelle Ferrante; Wan Cheung Cheung; Xiqiang Hong; Lucian R Chirieac; Lynette M Sholl; Herbert Haack; Bradley L Smith; Roberto D Polakiewicz; Yi Tan; Ting-Lei Gu; Massimo Loda; Xinmin Zhou; Michael J Comb
Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(9):3023-8.
2009: Sumin Kang; Shannon Elf; Shaozhong Dong; Taro Hitosugi; Katherine Lythgoe; Ailan Guo; Hong Ruan; Sagar Lonial; Hanna J Khoury; Ifor Williams; Benjamin H Lee; Johannes L Roesel; Gerard Karsenty; André Hanauer; Jack Taunton; Titus Boggon; Ting-Lei Gu; Jing Chen
Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
Molecular and cellular biology 2009;29(8):2105-17.
2009: Taro Hitosugi; Sumin Kang; Matthew G Vander Heiden; Tae-Wook Chung; Shannon Elf; Katherine Lythgoe; Shaozhong Dong; Sagar Lonial; Xu Wang; Georgia Z Chen; Jianxin Xie; Ting-Lei Gu; Roberto D Polakiewicz; Johannes L Roesel; Titus Boggon; Fadlo R Khuri; D Gary Gilliland; Lewis C Cantley; Jonathan Kaufman; Jing Chen
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Science signaling 2009;2(97):ra73.
2008: Winnie F Tam; Ting-Lei Gu; Jing Chen; Benjamin H Lee; Lars Bullinger; Stefan Fröhling; Zhuang Wang; Stefano Monti; Todd R Golub; D Gary Gilliland
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.
Blood 2008;112(5):1981-92.
2008: Sumin Kang; Shaozhong Dong; Ailan Guo; Hong Ruan; Sagar Lonial; Hanna Jean Khoury; Ting-Lei Gu; Jing Chen
Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.
The Journal of biological chemistry 2008;283(8):4652-7.
2007: Klarisa Rikova; Ailan Guo; Qingfu Zeng; Anthony Possemato; Jian Yu; Herbert Haack; Julie Nardone; Kimberly Lee; Cynthia Reeves; Yu Li; Yerong Hu; Zhiping Tan; Matthew Stokes; Laura Sullivan; Jeffrey Mitchell; Randy Wetzel; Joan MacNeill; Jian Min Ren; Jin Yuan; Corey E Bakalarski; Judit Villen; Jon M Kornhauser; Bradley Smith; Daiqiang Li; Xinmin Zhou; Steven P Gygi; Ting-Lei Gu; Roberto D Polakiewicz; John Rush; Michael J Comb
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Cell 2007;131(6):1190-203.
2007: Sumin Kang; Shaozhong Dong; Ting-Lei Gu; Ailan Guo; Michael S Cohen; Sagar Lonial; Hanna Jean Khoury; Doriano Fabbro; D Gary Gilliland; P Leif Bergsagel; Jack Taunton; Roberto D Polakiewicz; Jing Chen
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
Cancer cell 2007;12(3):201-14.
2007: Shaozhong Dong; Sumin Kang; Ting-Lei Gu; Sean Kardar; Haian Fu; Sagar Lonial; Hanna Jean Khoury; Fadlo R Khuri; Jing Chen
14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.
Blood 2007;110(1):360-9.
2007: Ting-Lei Gu; Thomas Mercher; Jeffrey W Tyner; Valerie L Goss; Denise K Walters; Melanie G Cornejo; Cynthia Reeves; Lana Popova; Kimberly Lee; Michael C Heinrich; John Rush; Masanori Daibata; Isao Miyoshi; D Gary Gilliland; Brian J Druker; Roberto D Polakiewicz
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
Blood 2007;110(1):323-33.
2007: Ting-Lei Gu; Lana Popova; Cynthia Reeves; Julie Nardone; Joan MacNeill; John Rush; Stephen D Nimer; Roberto D Polakiewicz
Phosphoproteomic analysis identifies the M0-91 cell line as a cellular model for the study of TEL-TRKC fusion-associated leukemia.
Leukemia 2007;21(3):563-6.
2007: Christina J Matheny; Maren E Speck; Patrick R Cushing; Yunpeng Zhou; Takeshi Corpora; Michael Regan; Miki Newman; Liya Roudaia; Caroline L Speck; Ting-Lei Gu; Stephen M Griffey; John H Bushweller; Nancy A Speck
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.
The EMBO journal 2007;26(4):1163-75.
2006: Ting-Lei Gu; Valerie L Goss; Cynthia Reeves; Lana Popova; Julie Nardone; Joan MacNeill; Denise K Walters; Yi Wang; John Rush; Michael J Comb; Brian J Druker; Roberto D Polakiewicz
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.
Blood 2006;108(13):4202-4.
2006: Thomas Mercher; Gerlinde Wernig; Sandra A Moore; Ross Levine; Ting-Lei Gu; Stefan Fröhling; Dana Cullen; Roberto D Polakiewicz; Olivier A Bernard; Titus Boggon; Benjamin H Lee; D Gary Gilliland
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.
Blood 2006;108(8):2770-9.
2006: Denise K Walters; Valerie L Goss; Eric P Stoffregen; Ting-Lei Gu; Kimberly Lee; Julie Nardone; Laura McGreevey; Michael C Heinrich; Michael W N Deininger; Roberto D Polakiewicz; Brian J Druker
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes.
Leukemia research 2006;30(9):1097-104.
2006: Denise K Walters; Thomas Mercher; Ting-Lei Gu; Thomas O'Hare; Jeffrey W Tyner; Marc Loriaux; Valerie L Goss; Kimberly A Lee; Christopher A Eide; Matthew Wong; Eric P Stoffregen; Laura McGreevey; Julie Nardone; Sandra A Moore; John Crispino; Titus Boggon; Michael C Heinrich; Michael W N Deininger; Roberto D Polakiewicz; D Gary Gilliland; Brian J Druker
Activating alleles of JAK3 in acute megakaryoblastic leukemia.
Cancer cell 2006;10(1):65-75.
2004: Ting-Lei Gu; Zuzana Tothova; Blanca Scheijen; James D Griffin; D Gary Gilliland; David W Sternberg
NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.
Blood 2004;103(12):4622-9.
2004: M Golam Mohi; Christina L Boulton; Ting-Lei Gu; David W Sternberg; Donna Neuberg; James D Griffin; D Gary Gilliland; Benjamin G Neel
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3130-5.
2000: Ting-Lei Gu; TL Goetz; Barbara J Graves; Nancy A Speck
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).
Molecular and cellular biology 2000;20(1):91-103.
2000: TL Goetz; Ting-Lei Gu; Nancy A Speck; Barbara J Graves
Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.
Molecular and cellular biology 2000;20(1):81-90.
1999: Trista E North; Ting-Lei Gu; Terryl Stacy; Qingru Wang; L Howard; Michael Binder; M Marín-Padilla; Nancy A Speck
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.
Development (Cambridge, England) 1999;126(11):2563-75.
1999: Nancy A Speck; Terryl Stacy; Qingru Wang; Trista E North; Ting-Lei Gu; J Miller; Michael Binder; M Marín-Padilla
Core-binding factor: a central player in hematopoiesis and leukemia.
Cancer research 1999;59(7 Suppl):1789s-1793s.
1996: Qingru Wang; Terryl Stacy; J D Miller; A F Lewis; Ting-Lei Gu; X Huang; John H Bushweller; J C Bories; F W Alt; G Ryan; P Paul Liu; Anthony Wynshaw-Boris; Michael Binder; M Marín-Padilla; A H Sharpe; Nancy A Speck
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
Cell 1996;87(4):697-708.