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Leonardo Guasti

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Leonardo Guasti; W C Candy Sze; Richard Grose; Tristan McKay; Peter J King
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.
Eirini Meimaridou; Li F Chan; J Paul Chapple; Adrian J L Clark; Leonardo Guasti; Claire R Hughes; Peter J King; Julia Kowalczyk; Louise A Metherell
Familial glucocorticoid deficiency: New genes and mechanisms.
Eirini Meimaridou; Peter Nürnberg; H Nurcin Saka; Florian Wagner; Ritwik Banerjee; J Paul Chapple; Adrian J L Clark; Peter Frommolt; Leonardo Guasti; Claire R Hughes; Peter J King; Julia Kowalczyk; Nicholas P Mann; Louise A Metherell
Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.

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All Publications

2013: Leonardo Guasti; W C Candy Sze; Richard Grose; Tristan McKay; Peter J King
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.
Molecular and cellular endocrinology 2013;371(1-2):182-8.
2013: Eirini Meimaridou; Li F Chan; J Paul Chapple; Adrian J L Clark; Leonardo Guasti; Claire R Hughes; Peter J King; Julia Kowalczyk; Louise A Metherell
Familial glucocorticoid deficiency: New genes and mechanisms.
Molecular and cellular endocrinology 2013;371(1-2):195-200.
2012: Eirini Meimaridou; Peter Nürnberg; H Nurcin Saka; Florian Wagner; Ritwik Banerjee; J Paul Chapple; Adrian J L Clark; Peter Frommolt; Leonardo Guasti; Claire R Hughes; Peter J King; Julia Kowalczyk; Nicholas P Mann; Louise A Metherell
Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.
Nature genetics 2012;44(7):740-2.
2011: Sadani Cooray; Leonardo Guasti; Adrian J L Clark
The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor.
Endocrinology 2011;152(11):4224-31.
2011: Rebecca J Gorrigan; Leonardo Guasti; Peter King; Adrian J Clark; Li F Chan
Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland.
Journal of molecular endocrinology 2011;46(3):227-32.
2011: Leonardo Guasti; Alex Paul; Ed Laufer; Peter King
Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex.
Molecular and cellular endocrinology 2011;336(1-2):117-22.
2010: Susana Igreja; Harvinder S Chahal; Peter King; Graeme B Bolger; Umasuthan Srirangalingam; Leonardo Guasti; J Paul Chapple; Giampaolo Trivellin; Maria Gueorguiev; Katie Guegan; Karen Stals; Bernard Khoo; Ajith V Kumar; Sian Ellard; Ashley B Grossman; Márta Korbonits
Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.
Human mutation 2010;31(8):950-60.
2009: Li F Chan; Tom R Webb; Teng-Teng Chung; Eirini Meimaridou; Sadani Cooray; Leonardo Guasti; J Paul Chapple; Michaela Egertová; Maurice R Elphick; Michael Cheetham; Louise A Metherell; Adrian J L Clark
MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6146-51.
2009: Leonardo Guasti; Denise Richardson; Maulik D Jhaveri; Khalil Eldeeb; David Barrett; Maurice R Elphick; S P H Alexander; David Kendall; Gregory J Michael; Victoria Chapman
Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain.
Molecular pain 2009;5():35.
2008: Mauro Pessia; Ilenio Servettini; R Panichi; Leonardo Guasti; Silvarosa Grassi; Annarosa Arcangeli; Enzo Wanke; Vito Enrico Pettorossi
ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones.
The Journal of physiology 2008;586(Pt 20):4877-90.
2008: Peter J King; Leonardo Guasti; Ed Laufer
Hedgehog signalling in endocrine development and disease.
The Journal of endocrinology 2008;198(3):439-50.
2008: Leonardo Guasti; Olivia Crociani; Elisa Redaelli; Serena Pillozzi; Simone Polvani; Marika Masselli; Tommaso Mello; Andrea Galli; Amedeo Amedei; Randy S Wymore; Enzo Wanke; Annarosa Arcangeli
Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells.
Molecular and cellular biology 2008;28(16):5043-60.
2007: Francesco Furlan; Giuliano Taccola; Micaela Grandolfo; Leonardo Guasti; Annarosa Arcangeli; Andrea Nistri; Laura Ballerini
ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):919-28.
2006: Rita Restano-Cassulini; Yuliya V Korolkova; Sylvie Diochot; Georgina B Gurrola; Leonardo Guasti; Lourival D Possani; Michel Lazdunski; Eugene V Grishin; Annarosa Arcangeli; Enzo Wanke
Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system.
Molecular pharmacology 2006;69(5):1673-83.
2005: Leonardo Guasti; Emanuele Cilia; Olivia Crociani; Giovanna Hofmann; Simone Polvani; Andrea Becchetti; Enzo Wanke; Filippo Tempia; Annarosa Arcangeli
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits.
The Journal of comparative neurology 2005;491(2):157-74.
2005: Alessia Cherubini; Giovanna Hofmann; Serena Pillozzi; Leonardo Guasti; Olivia Crociani; Emanuele Cilia; Paola Di Stefano; Simona Degani; Manuela Balzi; Massimo Olivotto; Enzo Wanke; Andrea Becchetti; Paola Defilippi; Randy S Wymore; Annarosa Arcangeli
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling.
Molecular biology of the cell 2005;16(6):2972-83.
2005: Francesco Furlan; Leonardo Guasti; D Avossa; Andrea Becchetti; Emanuele Cilia; Laura Ballerini; Annarosa Arcangeli
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro.
Neuroscience 2005;135(4):1179-92.
2004: Annarosa Arcangeli; Andrea Becchetti; Alessia Cherubini; Olivia Crociani; Paola Defilippi; Leonardo Guasti; Giovanna Hofmann; Serena Pillozzi; Massimo Olivotto; Enzo Wanke
Physical and functional interaction between integrins and hERG potassium channels.
Biochemical Society transactions 2004;32(Pt 5):826-7.
2004: Elena Lastraioli; Leonardo Guasti; Olivia Crociani; Simone Polvani; Giovanna Hofmann; Harry J Witchel; Lapo Bencini; Massimo Calistri; Luca Messerini; Marco Scatizzi; Renato Moretti; Enzo Wanke; Massimo Olivotto; Gabriele Mugnai; Annarosa Arcangeli
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.
Cancer research 2004;64(2):606-11.
2003: Francesca Gullo; Eva Ales; Barbara Rosati; Marzia Lecchi; Alessio Masi; Leonardo Guasti; Maria Francisca Cano-Abad; Annarosa Arcangeli; Manuela G Lopez; Enzo Wanke
ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):330-2.
2003: Olivia Crociani; Leonardo Guasti; Manuela Balzi; Andrea Becchetti; Enzo Wanke; Massimo Olivotto; Randy S Wymore; Annarosa Arcangeli
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells.
The Journal of biological chemistry 2003;278(5):2947-55.
2002: Alessia Cherubini; Serena Pillozzi; Giovanna Hofmann; Olivia Crociani; Leonardo Guasti; Elena Lastraioli; Simone Polvani; Alessio Masi; Andrea Becchetti; Enzo Wanke; Massimo Olivotto; Annarosa Arcangeli
HERG K+ channels and beta1 integrins interact through the assembly of a macromolecular complex.
Annals of the New York Academy of Sciences 2002;973():559-61.
2002: Serena Pillozzi; Maria Felice Brizzi; Manuela Balzi; Olivia Crociani; Alessia Cherubini; Leonardo Guasti; Benedetta Bartolozzi; Andrea Becchetti; Enzo Wanke; Pietro Antonio Bernabei; Massimo Olivotto; Luigi Pegoraro; Annarosa Arcangeli
HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.
Leukemia 2002;16(9):1791-8.
2001: Giovanna Hofmann; Pietro Antonio Bernabei; Olivia Crociani; Alessia Cherubini; Leonardo Guasti; Serena Pillozzi; Elena Lastraioli; Simone Polvani; Benedetta Bartolozzi; Vera Solazzo; Laura Gragnani; Paola Defilippi; Barbara Rosati; Enzo Wanke; Massimo Olivotto; Annarosa Arcangeli
HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1.
The Journal of biological chemistry 2001;276(7):4923-31.