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Josy Gubbens-Stibbe

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Sandra A G Visser; F L C Wolters; Josy M Gubbens-Stibbe; EJ Tukker; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations.
Klaas P Zuideveld; Nicoline Treijtel; Hugo J Maas; Josy M Gubbens-Stibbe; Lambertus A Peletier; Piet H van Der Graaf; Meindert Danhof
A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia.
M Garrido; Josy M Gubbens-Stibbe; EJ Tukker; E Cox; J von Frijtag; D Künzel; Adriaan P IJzerman; Meindert Danhof; Piet H van Der Graaf
Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo.

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All Publications

2003: Sandra A G Visser; F L C Wolters; Josy M Gubbens-Stibbe; EJ Tukker; Piet H van Der Graaf; Lambertus A Peletier; Meindert Danhof
Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations.
The Journal of pharmacology and experimental therapeutics 2003;304(1):88-101.
2002: Klaas P Zuideveld; Nicoline Treijtel; Hugo J Maas; Josy M Gubbens-Stibbe; Lambertus A Peletier; Piet H van Der Graaf; Meindert Danhof
A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia.
The Journal of pharmacology and experimental therapeutics 2002;300(1):330-8.
2000: M Garrido; Josy M Gubbens-Stibbe; EJ Tukker; E Cox; J von Frijtag; D Künzel; Adriaan P IJzerman; Meindert Danhof; Piet H van Der Graaf
Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo.
Pharmaceutical research 2000;17(6):653-9.
1999: EH Cox; MW Langemeijer; Josy M Gubbens-Stibbe; K T Muir; Meindert Danhof
The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model.
Anesthesiology 1999;90(2):535-44.
1998: Ronald van der Geest; Theo van Laar; P P Kruger; Josy M Gubbens-Stibbe; Harry E Boddé; Raymund A C Roos; Meindert Danhof
Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease.
Clinical neuropharmacology 1998;21(3):159-68.
1997: Ronald van der Geest; Theo van Laar; Josy M Gubbens-Stibbe; Harry E Boddé; Meindert Danhof
Iontophoretic delivery of apomorphine. II: An in vivo study in patients with Parkinson's disease.
Pharmaceutical research 1997;14(12):1804-10.
1997: Ronald van der Geest; P Kruger; Josy M Gubbens-Stibbe; Theo van Laar; H E Bodde; Meindert Danhof
Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronide and sulfate conjugates in plasma and urine of patients with Parkinson's disease.
Journal of chromatography. B, Biomedical sciences and applications 1997;702(1-2):131-41.
1997: EA van Schaick; R A Math-ot; Josy M Gubbens-Stibbe; MW Langemeijer; H C Roelen; Adriaan P IJzerman; Meindert Danhof
8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo.
The Journal of pharmacology and experimental therapeutics 1997;283(2):800-8.
1995: R A Mathôt; Josy M Gubbens-Stibbe; Willem Soudijn; Kenneth Alan Jacobson; Adriaan P IJzerman; Meindert Danhof
Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine.
The Journal of pharmacology and experimental therapeutics 1995;275(1):245-53.
1991: JW Mandema; Josy M Gubbens-Stibbe; Meindert Danhof
Stability and pharmacokinetics of flumazenil in the rat.
Psychopharmacology 1991;103(3):384-7.