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Andrei Gudkov

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Chemicals & Drugs

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Lyudmila G Burdelya; Alexander L Gintsburg; Ilya I Gitlin; Anatoli Gleiberman; Shyam Allamaneni; Nataliya M Artemicheva; Semra Aygun-Sunar; Craig M Brackett; Gary J Haderski; Christopher Johnson; Bojidar Kojouharov; Katerina I Leonova; Denis Y Logunov; Sergei S Makarov; Elena Martsen; Alexander Medvedev; Boris S Naroditsky; Dmitry Scheblyakov; Joseph Skitzki; Patricia Stanhope-Baker; Jean Veith; Ming Zeng; Andrei V Gudkov
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist.
Katerina I Leonova; Brittany Lipchick; Liliya Novototskaya; Mahadeb Pal; Ganes C Sen; Leonid Brodsky; Alex A Chenchik; Elena A Komarova; Andrei V Gudkov
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.
Sudha Mannava; Christopher K Mathews; Kalyana C Moparthy; Albert E Berman; Anna Bianchi-Smiraglia; Sheryl Flanagan; Andrei V Gudkov; Katerina I Leonova; Donna S Shewach; Joseph A Wawrzyniak; Linda J Wheeler; Nathalie C Zeitouni; Mikhail Nikiforov
Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.

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All Publications

2013: Lyudmila G Burdelya; Alexander L Gintsburg; Ilya I Gitlin; Anatoli Gleiberman; Shyam Allamaneni; Nataliya M Artemicheva; Semra Aygun-Sunar; Craig M Brackett; Gary J Haderski; Christopher Johnson; Bojidar Kojouharov; Katerina I Leonova; Denis Y Logunov; Sergei S Makarov; Elena Martsen; Alexander Medvedev; Boris S Naroditsky; Dmitry Scheblyakov; Joseph Skitzki; Patricia Stanhope-Baker; Jean Veith; Ming Zeng; Andrei V Gudkov
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(20):E1857-66.
2013: Katerina I Leonova; Brittany Lipchick; Liliya Novototskaya; Mahadeb Pal; Ganes C Sen; Leonid Brodsky; Alex A Chenchik; Elena A Komarova; Andrei V Gudkov
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):E89-98.
2012: Sudha Mannava; Christopher K Mathews; Kalyana C Moparthy; Albert E Berman; Anna Bianchi-Smiraglia; Sheryl Flanagan; Andrei V Gudkov; Katerina I Leonova; Donna S Shewach; Joseph A Wawrzyniak; Linda J Wheeler; Nathalie C Zeitouni; Mikhail Nikiforov
Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.
Aging 2012;4(12):917-22.
2012: Xilai Ding; Andrei V Gudkov; Nicholas D Leigh; Hong Liu; Philip L McCarthy; Jingxin Qiu; Semra Aygun-Sunar; Guanglin Bian; Lyudmila G Burdelya; Xuefang Cao
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4719-27.
2012: Vadim I Krivokrysenko; Ratan K Maitra; Andrei Purmal; Alexander N Shakhov; Inna Shyshynova; Vijay K Singh; Mark H Whitnall; Frederick Bone; Alec Cheney; Andrei V Gudkov; Yevgeniy Kononov; Elena Feinstein
Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure.
The Journal of pharmacology and experimental therapeutics 2012;343(2):497-508.
2012: Elena A Komarova; Olga V Leontieva; Liliya R Novototskaya; Geraldine Paszkiewicz; Marina P Antoch; Mikhail V Blagosklonny; Olga B Chernova; Andrei V Gudkov
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.
Aging 2012;4(10):709-14.
2012: Maria Comas; Andrei V Gudkov; KK Kuropatwinski; Alexander Polinsky; Ilia Toshkov; Mikhail V Blagosklonny; Olga B Chernova; Marina P Antoch
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.
Aging 2012;4(10):715-22.
2012: Mary L Spengler; Natalia M Artemicheva; Maria Comas; Krysta A Deluca; Natalia Fedtsova; Alexander V Gasparian; Ilya I Gitlin; Anatoli Gleiberman; Andrei V Gudkov; KK Kuropatwinski; Marina P Antoch
Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):E2457-65.
2012: Olga V Leontieva; Venkatesh Natarajan; Lyudmila G Burdelya; Zoya N Demidenko; Andrei V Gudkov; Mikhail V Blagosklonny
Hypoxia suppresses conversion from proliferative arrest to cellular senescence.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(33):13314-8.
2012: Igor E Koman; Song Liu; Carl Morrison; Srabani Pal; Geraldine Paszkiewicz; Andrei A Purmal; Alfiya Safina; Ilya Toshkov; Dan Wang; Mairead Commane; Andrei V Gudkov; Bhupinder Hoonjan; Katerina V Gurova
Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.
Cancer prevention research (Philadelphia, Pa.) 2012;5(8):1025-35.
2012: Vijay K Singh; Vera V Shakhova; Pankaj K Singh; Darren S Brown; Elizabeth J Ducey; Oluseyi O Fatanmi; Elena Feinstein; Andrei V Gudkov; Andrei Purmal; Alexander Shakhov
CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure.
Radiation research 2012;177(5):628-42.
2012: Lyudmila G Burdelya; Elena Feinstein; Anatoli S Gleiberman; Semra Aygun-Sunar; Meghana Bapardekar; David A Bellnier; Vadim I Krivokrysenko; Patricia Manderscheid-Kern; Ilia Toshkov; Andrei V Gudkov
Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy.
International journal of radiation oncology, biology, physics 2012;83(1):228-34.
2011: Yan Hu; Marilyn Jackson; KK Kuropatwinski; Youcef M Rustum; Mary L Spengler; Mikhail V Chernov; Maria Comas-Soberats; Natalia Fedtsova; Anatoly S Gleiberman; Andrei V Gudkov; Marina P Antoch
Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.
Oncotarget 2011;2(12):1279-90.
2011: Nobuyuki Fukuzawa; Andrei V Gudkov; Marianne Petro; William M Baldwin; Robert L Fairchild
A TLR5 agonist inhibits acute renal ischemic failure.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3831-9.
2011: Alexander V Gasparian; Andrei V Gudkov; Dmitry A Bosykh; Leonid Brodsky; Catherine A Burkhart; Mairead Commane; Olga A Guryanova; Igor E Koman; Anton A Komar; Mahadeb Pal; Srabani Pal; Andrei A Purmal; Alfiya Safina; Madhi Saranadasa; Sergey Sviridov; Jean Veith; Katerina V Gurova
Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.
Science translational medicine 2011;3(95):95ra74.
2011: Andrei V Gudkov; Katerina V Gurova; Elena A Komarova
Inflammation and p53: A Tale of Two Stresses.
Genes & cancer 2011;2(4):503-16.
2011: Nickolay Neznanov; Andrei P Komarov; Lubov Neznanova; Patricia Stanhope-Baker; Andrei V Gudkov
Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib.
Oncotarget 2011;2(3):209-21.
2011: Olga V Leontieva; Zoya N Demidenko; Andrei V Gudkov; Mikhail V Blagosklonny
Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin.
PloS one 2011;6(10):e26126.
2010: Olga V Leontieva; Andrei V Gudkov; Mikhail V Blagosklonny
Weak p53 permits senescence during cell cycle arrest.
Cell cycle (Georgetown, Tex.) 2010;9(21):4323-7.
2010: A I Tukhvatulin; D Yu Logunov; D N Shcherbinin; M M Shmarov; B S Naroditsky; Andrei V Gudkov; A L Gintsburg
Toll-like receptors and their adapter molecules.
Biochemistry. Biokhimii͡a 2010;75(9):1098-114.
2010: Alexander V Gasparian; Nickolay Neznanov; Sujata Jha; Oleksandr Galkin; John J Moran; Andrei V Gudkov; Katerina V Gurova; Anton A Komar
Inhibition of encephalomyocarditis virus and poliovirus replication by quinacrine: implications for the design and discovery of novel antiviral drugs.
Journal of virology 2010;84(18):9390-7.
2010: Andrei V Gudkov; Elena A Komarova
Pathologies associated with the p53 response.
Cold Spring Harbor perspectives in biology 2010;2(7):a001180.
2010: Lioubov G Korotchkina; Olga V Leontieva; Elena I Bukreeva; Zoya N Demidenko; Andrei V Gudkov; Mikhail V Blagosklonny
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.
Aging 2010;2(6):344-52.
2010: Zoya N Demidenko; Lioubov G Korotchkina; Andrei V Gudkov; Mikhail V Blagosklonny
Paradoxical suppression of cellular senescence by p53.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9660-4.
2010: Katerina I Leonova; Jelena Shneyder; Marina P Antoch; Illia A Toshkov; Liliya R Novototskaya; Pavel G Komarov; Elena A Komarova; Andrei V Gudkov
A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.
Cell cycle (Georgetown, Tex.) 2010;9(7):1434-43.
2010: Tao Lu; Mark Jackson; Benlian Wang; Maojing Yang; Mark R Chance; Masaru Miyagi; Andrei V Gudkov; George R Stark
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):46-51.
2009: Natalia V Narizhneva; Natalia D Tararova; Petro Ryabokon; Inna Shyshynova; Anatoly Prokvolit; Pavel G Komarov; Andrei A Purmal; Andrei V Gudkov; Katerina V Gurova
Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer.
Cell cycle (Georgetown, Tex.) 2009;8(24):4155-67.
2009: Tatiana V Pospelova; Zoya N Demidenko; Elena I Bukreeva; Valery A Pospelov; Andrei V Gudkov; Mikhail V Blagosklonny
Pseudo-DNA damage response in senescent cells.
Cell cycle (Georgetown, Tex.) 2009;8(24):4112-8.
2009: Nickolay Neznanov; Anton V Gorbachev; Lubov Neznanova; Andrei P Komarov; Katerina V Gurova; Alexander V Gasparian; Amiya K Banerjee; alex almasan; Robert L Fairchild; Andrei V Gudkov
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.
Cell cycle (Georgetown, Tex.) 2009;8(23):3960-70.
2009: Lioubov G Korotchkina; Zoya N Demidenko; Andrei V Gudkov; Mikhail V Blagosklonny
Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.
Cell cycle (Georgetown, Tex.) 2009;8(22):3777-81.
2009: Tao Lu; Mark Jackson; Aatur D Singhi; Eugene S Kandel; Maojing Yang; Yi Zhang; Andrei V Gudkov; George R Stark
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16339-44.
2009: Catherine A Burkhart; Fujiko Watt; Jayne Murray; Marina Pajic; Anatoly Prokvolit; Chengyuan Xue; Claudia Flemming; Janice Smith; Andrei Purmal; Nadezhda Isachenko; Pavel G Komarov; Katerina V Gurova; Alan C Sartorelli; Glenn M Marshall; Murray D Norris; Andrei V Gudkov; Michelle Haber
Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.
Cancer research 2009;69(16):6573-80.
2008: Andrei P Komarov; Oskar W Rokhlin; Chang-An Yu; Andrei V Gudkov
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14453-8.
2008: Julia E Kravchenko; Galina V Ilyinskaya; Pavel G Komarov; Larissa S Agapova; D V Kochetkov; E Strom; E I Frolova; I Kovriga; Andrei V Gudkov; Elena Feinstein; Peter Chumakov
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6302-7.
2008: Lyudmila G Burdelya; Vadim I Krivokrysenko; Thomas C Tallant; Evguenia Strom; Anatoly S Gleiberman; Damodar Gupta; Oleg V Kurnasov; Farrel L Fort; Andrei Osterman; Joseph A Didonato; Elena Feinstein; Andrei V Gudkov
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.
Science (New York, N.Y.) 2008;320(5873):226-30.
2008: Nickolay Neznanov; Anna A Kondratova; Konstantin Chumakov; Lubov Neznanova; Roman Kondratov; Amiya Banerja; Andrei V Gudkov
Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin.
DNA and cell biology 2008;27(4):191-8.
2008: Nickolay Neznanov; Eugenia M Dragunsky; Konstantin Chumakov; Lubov Neznanova; Ronald C Wek; Andrei V Gudkov; Amiya Banerja
Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication.
PloS one 2008;3(4):e1887.
2007: Natalia D Tararova; Natalya Narizhneva; Vadim Krivokrisenko; Andrei V Gudkov; Katerina V Gurova
Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity.
The Prostate 2007;67(16):1801-15.
2007: Chengyuan Xue; Michelle Haber; Claudia Flemming; Glenn M Marshall; Richard B Lock; Karen L MacKenzie; Katerina V Gurova; Murray D Norris; Andrei V Gudkov
p53 determines multidrug sensitivity of childhood neuroblastoma.
Cancer research 2007;67(21):10351-60.
2007: Anton V Gorbachev; Alexander V Gasparian; Katerina V Gurova; Andrei V Gudkov; Robert L Fairchild
Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation.
European journal of immunology 2007;37(8):2257-67.
2007: Andrei V Gudkov; Elena A Komarova
Dangerous habits of a security guard: the two faces of p53 as a drug target.
Human molecular genetics 2007;16 Spec No 1():R67-72.
2006: Lyudmila G Burdelya; Elena A Komarova; Jason E Hill; Timothy Browder; Natalia D Tararova; Lori Mavrakis; Paul E DiCorleto; Judah Folkman; Andrei V Gudkov
Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice.
Cancer research 2006;66(19):9356-61.
2006: Kenichi Chikamori; Jason E Hill; Dale R Grabowski; E Zarkhin; A G Grozav; Susan A J Vaziri; J Wang; Andrei V Gudkov; Lisa R Rybicki; Ronald M Bukowski; A Yen; M Tanimoto; Mahrukh K Ganapathi; Ram Ganapathi
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Leukemia 2006;20(10):1809-18.
2006: Evguenia Strom; Swati Sathe; Pavel G Komarov; Olga B Chernova; Ivanda Pavlovska; Inna Shyshynova; Dmitry A Bosykh; Lyudmila G Burdelya; Roger M Macklis; Rami Skaliter; Elena A Komarova; Andrei V Gudkov
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
Nature chemical biology 2006;2(9):474-9.
2006: John T Patton; Lindsey D Mayo; Aatur D Singhi; Andrei V Gudkov; George R Stark; Mark Jackson
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.
Cancer research 2006;66(6):3169-76.
2006: Julia V Kichina; M Zeremski; L Aris; Katerina V Gurova; E Walker; Roberta Franks; Alexander Nikitin; Hiroaki Kiyokawa; Andrei V Gudkov
Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas.
Oncogene 2006;25(6):857-66.
2006: Alexander D. Boiko; Sarah Porteous; Olga V Razorenova; Vadim I Krivokrysenko; Bryan R G Williams; Andrei V Gudkov
A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.
Genes & development 2006;20(2):236-52.
2005: Susan A J Vaziri; Jason Hill; Kenichi Chikamori; Dale R Grabowski; Nagio Takigawa; Mamta Chawla-Sarkar; Lisa R Rybicki; Andrei V Gudkov; Tarek Mekhail; Ronald M Bukowski; Mahrukh K Ganapathi; Ram Ganapathi
Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Molecular cancer therapeutics 2005;4(12):1880-90.
2005: Nickolay Neznanov; Lubov Neznanova; Brigitte Angres; Andrei V Gudkov
Serologically defined colon cancer antigen 3 is necessary for the presentation of TNF receptor 1 on cell surface.
DNA and cell biology 2005;24(12):777-85.
2005: Katerina V Gurova; Jason E Hill; Canhui Guo; Anatoly Prokvolit; Lyudmila G Burdelya; Eugenia Samoylova; Anna V Khodyakova; Ram Ganapathi; Mahrukh K Ganapathi; Natalia D Tararova; Dmitry Bosykh; Dmitriy Lvovskiy; Thomas R Webb; George R Stark; Andrei V Gudkov
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17448-53.
2005: Anna A Kondratova; Nickolay Neznanov; Roman V Kondratov; Andrei V Gudkov
Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division.
Cell cycle (Georgetown, Tex.) 2005;4(10):1403-10.
2005: Nickolay Neznanov; Konstantin Chumakov; Lubov Neznanova; alex almasan; Amiya Banerja; Andrei V Gudkov
Proteolytic cleavage of the p65-RelA subunit of NF-kappaB during poliovirus infection.
The Journal of biological chemistry 2005;280(25):24153-8.
2005: Andrei V Gudkov; Elena A Komarova
Prospective therapeutic applications of p53 inhibitors.
Biochemical and biophysical research communications 2005;331(3):726-36.
2005: Elena A Komarova; Vadim I Krivokrysenko; Kaihua Wang; Nickolay Neznanov; Mikhail V Chernov; Pavel G Komarov; Marie-Luise Brennan; Tatyana V Golovkina; Oskar W Rokhlin; Dmitry V Kuprash; Sergei A Nedospasov; Stanley L Hazen; Elena Feinstein; Andrei V Gudkov
p53 is a suppressor of inflammatory response in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):1030-2.
2005: Victoria Y Gorbacheva; Roman V Kondratov; Renliang Zhang; Srujana Cherukuri; Andrei V Gudkov; Joseph S Takahashi; Marina P Antoch
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3407-12.
2004: Aatur D Singhi; Roman V Kondratov; Nickolay Neznanov; Mikhail V Chernov; Andrei V Gudkov
Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9327-32.
2004: Tao Lu; Lyudmila G Burdelya; Shannon M Swiatkowski; Alexander D. Boiko; Philip H Howe; George R Stark; Andrei V Gudkov
Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7112-7.
2004: Elena A Komarova; Roman V Kondratov; Kaihua Wang; Konstantin Christov-Tzelkov; Tatyana V Golovkina; John R Goldblum; Andrei V Gudkov
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.
Oncogene 2004;23(19):3265-71.
2004: Katerina V Gurova; Jason E Hill; Olga V Razorenova; Peter Chumakov; Andrei V Gudkov
p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.
Cancer research 2004;64(6):1951-8.
2004: Nickolay Neznanov; Lubov Neznanova; Roman V Kondratov; Donald M O'Rourke; Axel Ullrich; Andrei V Gudkov
The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha.
DNA and cell biology 2004;23(3):175-82.
2003: Roman V Kondratov; Mikhail V Chernov; Anna A Kondratova; Victoria Y Gorbacheva; Andrei V Gudkov; Marina P Antoch
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.
Genes & development 2003;17(15):1921-32.
2003: Julia V Kichina; Sikha Rauth; Tapas K Das Gupta; Andrei V Gudkov
Melanoma cells can tolerate high levels of transcriptionally active endogenous p53 but are sensitive to retrovirus-transduced p53.
Oncogene 2003;22(31):4911-7.
2003: Katerina V Gurova; Oskar W Rokhlin; Andrei V Budanov; Lyudmila G Burdelya; Peter Chumakov; Michael B Cohen; Andrei V Gudkov
Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells.
Cancer research 2003;63(11):2905-12.
2003: Elena A Komarova; Nickolay Neznanov; Pavel G Komarov; Mikhail V Chernov; Kaihua Wang; Andrei V Gudkov
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.
The Journal of biological chemistry 2003;278(18):15465-8.
2003: Nickolay Neznanov; Lubov Neznanova; Roman V Kondratov; Lyudmila G Burdelya; Eugene S Kandel; Donald M O'Rourke; Axel Ullrich; Andrei V Gudkov
Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.
The Journal of biological chemistry 2003;278(6):3809-15.
2003: Andrei V Gudkov; Elena A Komarova
The role of p53 in determining sensitivity to radiotherapy.
Nature reviews. Cancer 2003;3(2):117-29.
2003: Igor B Roninson; Andrei V Gudkov
Genetic suppressor elements in the characterization and identification of tumor suppressor genes.
Methods in molecular biology (Clifton, N.J.) 2003;222():413-36.
2003: Katerina V Gurova; Andrei V Gudkov
Paradoxical role of apoptosis in tumor progression.
Journal of cellular biochemistry 2003;88(1):128-37.
2002: Xianghong Zou; Dipankar Ray; Aileen Aziyu; Konstantin Christov-Tzelkov; Alexander D. Boiko; Andrei V Gudkov; Hiroaki Kiyokawa
Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.
Genes & development 2002;16(22):2923-34.
2002: Nickolay Neznanov; Konstantin P Chumakov; Axel Ullrich; Vadim I Agol; Andrei V Gudkov
Unstable receptors disappear from cell surface during poliovirus infection.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(10):BR391-6.
2002: Oskar W Rokhlin; Rebecca A Glover; Agshin F Taghiyev; Natalya V Guseva; Richard E B Seftor; Inna Shyshynova; Andrei V Gudkov; Michael B Cohen
Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription.
The Journal of biological chemistry 2002;277(36):33213-9.
2002: Andrei V Budanov; Tzipora Shoshani; Alexander Faerman; Elena Zelin; Iris Kamer; Hagar Kalinski; Svetlana Gorodin; Alla Fishman; Ayelet Chajut; Paz Einat; Rami Skaliter; Andrei V Gudkov; Peter Chumakov; Elena Feinstein
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.
Oncogene 2002;21(39):6017-31.
2002: Katerina V Gurova; Oskar W Roklin; Vadim I Krivokrysenko; Peter Chumakov; Michael B Cohen; Elena Feinstein; Andrei V Gudkov
Expression of prostate specific antigen (PSA) is negatively regulated by p53.
Oncogene 2002;21(1):153-7.
2002: Katerina V Gurova; Serena S S Kwek; Igor E Koman; Andrei P Komarov; Eugene Kandel; Mikhail Nikiforov; Andrei V Gudkov
Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor.
Cancer biology & therapy 2002;1(1):39-44.
2001: Igor Garkavtsev; N Kley; IA Grigorian; Andrei V Gudkov
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
Oncogene 2001;20(57):8276-80.
2001: Roman V Kondratov; Pavel G Komarov; Y Becker; Ariel Ewenson; Andrei V Gudkov
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14078-83.
2001: Nickolay Neznanov; Anna A Kondratova; Konstantin Chumakov; B Angres; B Zhumabayeva; Vadim I Agol; Andrei V Gudkov
Poliovirus protein 3A inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface.
Journal of virology 2001;75(21):10409-20.
2001: Elena A Komarova; Andrei V Gudkov
Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors.
Biochemical pharmacology 2001;62(6):657-67.
2001: Vladimir A Botchkarev; Elena A Komarova; Frank Siebenhaar; Natalia V Botchkareva; Andrey A Sharov; Pavel G Komarov; Marcus Maurer; Andrei V Gudkov; Barbara A Gilchrest
p53 Involvement in the control of murine hair follicle regression.
The American journal of pathology 2001;158(6):1913-9.
2001: Serena S S Kwek; Jason J Derry; Angela L Tyner; Z Shen; Andrei V Gudkov
Functional analysis and intracellular localization of p53 modified by SUMO-1.
Oncogene 2001;20(20):2587-99.
2001: Dorota Skowyra; M Zeremski; Nickolay Neznanov; M Li; Youngsok Choi; Motonari Uesugi; Craig A Hauser; W Gu; Andrei V Gudkov; Jun Qin
Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.
The Journal of biological chemistry 2001;276(12):8734-9.
2001: Sarah S Bacus; Andrei V Gudkov; M Lowe; Ljuba Lyass; Y Yung; A P Komarov; Khandan Keyomarsi; Yosef Yarden; Rony Seger
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.
Oncogene 2001;20(2):147-55.
2000: Vladimir A Botchkarev; Elena A Komarova; Frank Siebenhaar; Natalia V Botchkareva; Pavel G Komarov; Marcus Maurer; Barbara A Gilchrest; Andrei V Gudkov
p53 is essential for chemotherapy-induced hair loss.
Cancer research 2000;60(18):5002-6.
2000: Elena A Komarova; Konstantin Christov-Tzelkov; Alexander Faerman; Andrei V Gudkov
Different impact of p53 and p21 on the radiation response of mouse tissues.
Oncogene 2000;19(33):3791-8.
2000: Oskar W Rokhlin; Andrei V Gudkov; Serena S S Kwek; Rebecca A Glover; Andreas Gewies; Michael B Cohen
p53 is involved in tumor necrosis factor-alpha-induced apoptosis in the human prostatic carcinoma cell line LNCaP.
Oncogene 2000;19(15):1959-68.
2000: Sarah S Bacus; Andrei V Gudkov; Francisco J Esteva; Yosef Yarden
Expression of erbB receptors and their ligands in breast cancer: implications to biological behavior and therapeutic response.
Breast disease 2000;11():63-75.
2000: Elena A Komarova; Andrei V Gudkov
Suppression of p53: a new approach to overcome side effects of antitumor therapy.
Biochemistry. Biokhimii͡a 2000;65(1):41-8.
1999: M Zeremski; J E Hill; Serena S S Kwek; IA Grigorian; Katerina V Gurova; Igor Garkavtsev; Luda Diatchenko; E V Koonin; Andrei V Gudkov
Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function.
The Journal of biological chemistry 1999;274(45):32172-81.
1999: Pavel G Komarov; Elena A Komarova; Roman V Kondratov; K Christov-Tselkov; John S Coon; Mikhail V Chernov; Andrei V Gudkov
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Science (New York, N.Y.) 1999;285(5434):1733-7.
1999: J M Mittelman; Andrei V Gudkov
Generation of p53 suppressor peptide from the fragment of p53 protein.
Somatic cell and molecular genetics 1999;25(3):115-28.
1999: G R Stark; Andrei V Gudkov
Forward genetics in mammalian cells: functional approaches to gene discovery.
Human molecular genetics 1999;8(10):1925-38.
1998: Elena A Komarova; Luda Diatchenko; Oskar W Rokhlin; J E Hill; Z J Wang; Vadim I Krivokrysenko; Elena Feinstein; Andrei V Gudkov
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.
Oncogene 1998;17(9):1089-96.
1998: Sergey A Axenovich; A R Kazarov; Alexander D. Boiko; G Armin; Igor B Roninson; Andrei V Gudkov
Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response.
Cancer research 1998;58(15):3423-8.
1998: G J Deichman; Valentina A Matveeva; Lydia M Kashkina; Natalya A Dyakova; EN Uvarova; Mikhail Nikiforov; Andrei V Gudkov
Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes.
International journal of cancer. Journal international du cancer 1998;75(2):277-83.
1998: Elena A Komarova; Andrei V Gudkov
Could p53 be a target for therapeutic suppression?
Seminars in cancer biology 1998;8(5):389-400.
1997: Mikhail Nikiforov; Serena S S Kwek; Rajendra Mehta; James E Artwohl; Scott W Lowe; T D Gupta; G I Deichman; Andrei V Gudkov
Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence.
Oncogene 1997;15(25):3007-12.
1997: Elena A Komarova; CR Zelnick; D Chin; M Zeremski; A S Gleiberman; Sarah S Bacus; Andrei V Gudkov
Intracellular localization of p53 tumor suppressor protein in gamma-irradiated cells is cell cycle regulated and determined by the nucleus.
Cancer research 1997;57(23):5217-20.
1997: Oskar W Rokhlin; Bruce S Hostager; Gail A Bishop; S P Sidorenko; Rebecca A Glover; Andrei V Gudkov; Michael B Cohen
Dominant nature of the resistance to Fas- and tumor necrosis factor-alpha-mediated apoptosis in human prostatic carcinoma cell lines.
Cancer research 1997;57(18):3941-3.
1997: ES Kandel; Bey-Dih Chang; B Schott; Alexander A Shtil; Andrei V Gudkov; Igor B Roninson
Applications of green fluorescent protein as a marker of retroviral vectors.
Somatic cell and molecular genetics 1997;23(5):325-40.
1997: M Zeremski; stephen horrigan; IA Grigorian; Carol A Westbrook; Andrei V Gudkov
Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34.
Somatic cell and molecular genetics 1997;23(3):233-6.
1997: Elena A Komarova; Mikhail V Chernov; Roberta Franks; K Wang; G Armin; CR Zelnick; Dot Mon Chin; Sarah S Bacus; George R Stark; Andrei V Gudkov
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.
The EMBO journal 1997;16(6):1391-400.
1997: Andrei V Gudkov; Igor B Roninson
Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors.
Methods in molecular biology (Clifton, N.J.) 1997;69():221-40.
1996: Mikhail Nikiforov; K Hagen; V S Ossovskaya; T M Connor; Scott W Lowe; Galina I Deichman; Andrei V Gudkov
p53 modulation of anchorage independent growth and experimental metastasis.
Oncogene 1996;13(8):1709-19.
1996: V S Ossovskaya; Ilya Mazo; Mikhail V Chernov; Olga Chernova; Z Strezoska; R Kondratov; George R Stark; Peter Chumakov; Andrei V Gudkov
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10309-14.
1996: Galina I Deichman; Lydia M Kashkina; O A Mizenina; E G Gorojanskaya; Mikhail Nikiforov; Andrei V Gudkov; Natalya A Dyakova; A V Komelkov; M O Prilutskaya; N E Kushlinsky; Alexander Tatosyan
Mechanisms of unusually high antioxidant activity of RSV-SR-transformed cells and of its suppression by activated p21ras.
International journal of cancer. Journal international du cancer 1996;66(6):747-52.
1995: Igor B Roninson; Andrei V Gudkov; Tatyana A Holzmayer; D J Kirschling; A R Kazarov; C R Zelnick; Ilya Mazo; S Axenovich; R Thimmapaya
Genetic suppressor elements: new tools for molecular oncology--thirteenth Cornelius P. Rhoads Memorial Award Lecture.
Cancer research 1995;55(18):4023-8.
1994: Andrei V Gudkov; A R Kazarov; R Thimmapaya; S A Axenovich; Ilya Mazo; Igor B Roninson
Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3744-8.
1994: Mikhail Nikiforov; Andrei V Gudkov
ART-CH: a VL30 in chickens?
Journal of virology 1994;68(2):846-53.
1993: Sarah S Bacus; Andrei V Gudkov; C R Zelnick; D Chin; R Stern; I Stancovski; Elior Peles; N Ben-Baruch; H Farbstein; R Lupu
Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumors.
Cancer research 1993;53(21):5251-61.
1993: Andrei V Gudkov; C R Zelnick; A R Kazarov; R Thimmapaya; D P Suttle; William T Beck; Igor B Roninson
Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3231-5.
1992: Andrei V Gudkov; Elena A Komarova; Mikhail Nikiforov; T E Zaitsevskaya
ART-CH, a new chicken retroviruslike element.
Journal of virology 1992;66(3):1726-36.
1991: Andrei Thomas-Tikhonenko; A V Polotskaya; N S Vassetzky; Tatyana V Golovkina; Andrei V Gudkov
Long terminal repeats of dwarf hamster endogenous retrovirus are highly diverged and do not maintain efficient transcription.
Virology 1991;181(1):367-70.
1990: Tatyana V Golovkina; Andrei Thomas-Tikhonenko; N S Vassetzky; B I Sheftel; Andrei V Gudkov
Distribution of mouse mammary tumor virus-related sequences does not correlate with the taxonomic position of their hosts.
Virus genes 1990;4(1):85-92.
1990: Andrei Thomas-Tikhonenko; N S Vassetzky; Tatyana V Golovkina; Andrei V Gudkov
Molecular cloning and primary structure analysis of the mouse mammary tumor virus-related element from dwarf hamster genome.
Virus genes 1990;3(3):259-61.
1990: T E Zaĭtsevskaia; Mikhail V Chernov; Elena A Komarova; IA Grigorian; R A Denisova; I Heinar; I Nechiba; J Svoboda; Andrei V Gudkov
[The tissue specificity of the expression of the avian sarcoma-leukosis complex viruses].
Doklady Akademii nauk SSSR 1990;313(4):983-6.
1990: Tatyana V Golovkina; Andrei Thomas-Tikhonenko; N S Vasetskiĭ; B I Sheftel'; Andrei V Gudkov
[Sequences homologous to mouse mammary cancer virus are common in mammalian and avian genomes].
Molekuliarnaia biologiia 1990;24(1):127-33.
1989: Andrei V Gudkov; K N Kashkin; T E Zaitsevskaya; S M Troyanovsky
Histo-blotting: hybridization in situ detection of specific RNAs on tissue sections transferred on nitrocellulose.
International journal of cancer. Journal international du cancer 1989;44(6):1052-6.
1989: N S Vasetskiĭ; Andrei Thomas-Tikhonenko; Tatyana V Golovkina; Andrei V Gudkov
[Cloning and analysis of the primary structure of an element, related to the murine mammary cancer virus, from the genome of the Djungarian hamster].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1989;(10):16-9.
1988: O I Sokova; E Iu Siianova; Andrei V Gudkov; Boris P Kopnin
[Amplification of regions of the genome in the somatic cells of mammals resistant to colchicine. VII. Localization of the initial and amplified copies of gene mdr in one and the same segment of chromosome 4 of the Djungarian hamster].
Genetika 1988;24(5):836-41.
1987: Andrei V Gudkov; O B Chernova; A R Kazarov; Boris P Kopnin
Cloning and characterization of DNA sequences amplified in multidrug-resistant Djungarian hamster and mouse cells.
Somatic cell and molecular genetics 1987;13(6):609-19.
1987: N S Demidova; S A Goncharova; O B Chernova; Boris P Kopnin; Andrei V Gudkov
[Gene amplification in murine leukemia cells with multiple drug resistance acquired in vivo].
Genetika 1987;23(10):1797-806.
1987: K N Kashkin; S M Troianovskiĭ; Andrei V Gudkov
[Detection of tissue-specific gene expression using an in situ hybridization method of histoblotting].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1987;(9):16-8.
1987: Andrei Thomas-Tikhonenko; Andrei V Gudkov
[Endogenous proretroviruses and other autonomous retroposons: traces of viral origin or decay?].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1987;(7):3-11.
1987: Andrei V Gudkov; O B Chernova; A R Kazarov; B P Kopnin
[Pattern of evolution of amplicons during the development of multiple drug resistance in Djungarian hamster cells].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1987;(6):33-8.
1987: O B Chernova; V I Shifrin; O I Sokova; B P Kopnin; Andrei V Gudkov
[Cloning and characteristics of DNA sequences amplified in Djungarian hamster cells with multidrug resistance].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1987;(4):14-9.
1986: Mikhail V Chernov; Andrei V Gudkov; I B Obukh; R A Denisova; N S Gorbacheva
[Characteristics of new loci of endogenous proviruses in chickens].
Voprosy virusologii 1986;31(2):216-20.
1986: Andrei V Gudkov; O B Chernova; E Iu Sianova; O I Sokova; Boris P Kopnin
[Isolation of DNA probes for the detection of sequences amplified in colchicine-resistant cells].
Molekuliarnaia biologiia 1986;20(1):146-53.
1986: Andrei V Gudkov; Mikhail V Chernov; Andrei Thomas-Tikhonenko; I B Obukh; I Hlozánek
Methylation of endogenous proviruses of Brown Leghorn chickens.
Folia biologica 1986;32(1):73-7.
1986: Andrei V Gudkov; E Korec; Mikhail V Chernov; Andrei Thomas-Tikhonenko; I B Obukh; I Hlozánek
Genetic structure of the endogenous proviruses and expression of the gag gene in Brown Leghorn chickens.
Folia biologica 1986;32(1):65-72.
1985: Boris P Kopnin; J S Massino; Andrei V Gudkov
Regular pattern of karyotypic alterations accompanying gene amplification in Djungarian hamster cells: study of colchicine, adriablastin, and methotrexate resistance.
Chromosoma 1985;92(1):25-36.
1985: Andrei Thomas-Tikhonenko; Mikhail V Chernov; I B Obukh; Andrei V Gudkov
[Possible mechanisms of the occurrence of new loci of defective endogenous proviruses].
Doklady Akademii nauk SSSR 1985;282(5):1259-62.
1985: Andrei V Gudkov; J S Massino; O B Chernova; Boris P Kopnin
Gene amplification in Djungarian hamster cell lines possessing decreased plasma membrane permeability for colchicine and some other drugs.
Chromosoma 1985;92(1):16-24.
1984: Mikhail V Chernov; Andrei V Gudkov; I B Obukh
Variations of endogenous chicken proviruses: characterization of new loci of endogenous proviruses in the genome of Italian partridge chickens.
Folia biologica 1984;30(5):342-8.
1983: Andrei V Gudkov; I B Obukh; S M Serov
Localization of provirus DNA of Rous sarcoma virus in the DNA of infected, transformed and tumour cells of chickens.
Folia biologica 1983;29(3):221-9.
1981: Andrei V Gudkov; I B Obukh; S M Serov; B S Naroditsky
Variety of endogenous proviruses in the genomes of chickens of different breeds.
The Journal of general virology 1981;57(Pt 1):85-94.
1981: Andrei V Gudkov; S M Serov; I B Obukh; B S Naroditskiĭ
[New endogenous proviruses in the genome of brown Leghorn chickens].
Voprosy virusologii 1981;(2):225-8.