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Daniel Guénard

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Zhi-Wei Chen; Daniel Guénard; Françoise Guéritte; Adil Jaafar; Florence Lederer; Bernard Lévy; Caroline Vignaud; F Scott Mathews
High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.
Quoc Anh Ngo; Fanny Roussi; Anthony Cormier; Sylviane Thoret; Marcel Knossow; Daniel Guénard; Françoise Guéritte
Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids.
Anne-Laure Larroque; Joëlle Dubois; Sylviane Thoret; Geneviève Aubert; Angèle Chiaroni; Françoise Guéritte; Daniel Guénard
Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 2: synthesis and biological activities of docetaxel analogues with a peptide side chain at C2 and their macrocyclic derivatives.

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All Publications

2012: Zhi-Wei Chen; Daniel Guénard; Françoise Guéritte; Adil Jaafar; Florence Lederer; Bernard Lévy; Caroline Vignaud; F Scott Mathews
High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.
Biochimie 2012;94(5):1172-9.
2009: Quoc Anh Ngo; Fanny Roussi; Anthony Cormier; Sylviane Thoret; Marcel Knossow; Daniel Guénard; Françoise Guéritte
Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids.
Journal of medicinal chemistry 2009;52(1):134-42.
2007: Anne-Laure Larroque; Joëlle Dubois; Sylviane Thoret; Geneviève Aubert; Angèle Chiaroni; Françoise Guéritte; Daniel Guénard
Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 2: synthesis and biological activities of docetaxel analogues with a peptide side chain at C2 and their macrocyclic derivatives.
Bioorganic & medicinal chemistry 2007;15(1):563-74.
2006: Grégory Dupeyre; Guy G Chabot; Sylviane Thoret; Xavier Cachet; Johanne Seguin; Daniel Guénard; François Tillequin; Daniel Scherman; Michel Koch; Sylvie Michel
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.
Bioorganic & medicinal chemistry 2006;14(13):4410-26.
2006: Sylviane Thoret; Françoise Guéritte; Daniel Guénard; Joëlle Dubois
Semisynthesis and biological evaluation of a novel D-seco docetaxel analogue.
Organic letters 2006;8(11):2301-4.
2006: Anne Décor; Barbara Monse; Marie-Thérèse Martin; Angèle Chiaroni; Sylviane Thoret; Daniel Guénard; Françoise Guéritte; Olivier Baudoin
Synthesis and biological evaluation of B-ring analogues of (-)-rhazinilam.
Bioorganic & medicinal chemistry 2006;14(7):2314-32.
2005: Anne-Laure Larroque; Joëlle Dubois; Sylviane Thoret; Geneviève Aubert; Daniel Guénard; Françoise Guéritte
Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 1: Synthesis and biological activities of docetaxel analogues with a peptide side chain at C3'.
Bioorganic & medicinal chemistry letters 2005;15(21):4722-6.
2005: Christine Borrel; Sylviane Thoret; Xavier Cachet; Daniel Guénard; François Tillequin; Michel Koch; Sylvie Michel
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.
Bioorganic & medicinal chemistry 2005;13(11):3853-64.
2005: Frank Büttner; Silke Bergemann; Daniel Guénard; Ronald Gust; Gunther Seitz; Sylviane Thoret
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity.
Bioorganic & medicinal chemistry 2005;13(10):3497-511.
2005: Phuong Mai Le; Marie-Thérèse Martin; Nguyen Van Hung; Daniel Guénard; Thierry Sévenet; Nicole Platzer
NMR study of quinolizidine alkaloids: relative configurations, conformations.
Magnetic resonance in chemistry : MRC 2005;43(4):283-93.
2005: Shai Rubnov; Camille Chevallier; Odile Thoison; Cécile Debitus; Olivier Laprevote; Daniel Guénard; Thierry Sévenet
Echinosulfonic acid D: an ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp.
Natural product research 2005;19(1):75-9.
2004: Harry M Greenblatt; Catherine Guillou; Daniel Guénard; Anat Argaman; Simone Botti; Bernard Badet; Claude Thal; Israel Silman; Joel Sussman
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
Journal of the American Chemical Society 2004;126(47):15405-11.
2004: Olivier Querolle; Joëlle Dubois; Sylviane Thoret; Fanny Roussi; Françoise Guéritte; Daniel Guénard
Synthesis of C2-C3'N-linked macrocyclic taxoids. Novel docetaxel analogues with high tubulin activity.
Journal of medicinal chemistry 2004;47(24):5937-44.
2004: Camille Chevallier; Olivier Laprévote; Jérôme Bignon; Cécile Debitus; Daniel Guénard; Thierry Sévenet
Isolation of cytotoxic chondropsins, macrolide lactams from the New-Caledonian marine sponge Psammoclemma sp. and electrospray ion trap multiple stage MS study of these macrolides.
Natural product research 2004;18(5):479-84.
2003: Vaishali Deka; Joëlle Dubois; Sylviane Thoret; Françoise Guéritte; Daniel Guénard
Deletion of the oxetane ring in docetaxel analogues: synthesis and biological evaluation.
Organic letters 2003;5(26):5031-4.
2003: Olivier Querolle; Joëlle Dubois; Sylviane Thoret; Fanny Roussi; Sara Montiel-Smith; Françoise Guéritte; Daniel Guénard
Synthesis of novel macrocyclic docetaxel analogues. Influence of their macrocyclic ring size on tubulin activity.
Journal of medicinal chemistry 2003;46(17):3623-30.
2003: Audrey Herrbach; Angela Marinetti; Olivier Baudoin; Daniel Guénard; Françoise Guéritte
Asymmetric synthesis of an axially chiral antimitotic biaryl via an atropo-enantioselective Suzuki cross-coupling.
The Journal of organic chemistry 2003;68(12):4897-905.
2003: Silke Bergemann; René Brecht; Frank Büttner; Daniel Guénard; Ronald Gust; Gunther Seitz; Milton T Stubbs; Sylviane Thoret
Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity.
Bioorganic & medicinal chemistry 2003;11(7):1269-81.
2002: Olivier Baudoin; Fabien Claveau; Sylviane Thoret; Audrey Herrbach; Daniel Guénard; Françoise Guéritte
Synthesis and biological evaluation of A-ring biaryl-carbamate analogues of rhazinilam.
Bioorganic & medicinal chemistry 2002;10(11):3395-400.
2002: Olivier Baudoin; Michèle Cesario; Daniel Guénard; Françoise Guéritte
Application of the palladium-catalyzed borylation/Suzuki coupling (BSC) reaction to the synthesis of biologically active biaryl lactams.
The Journal of organic chemistry 2002;67(4):1199-207.
2002: Le Phuong Mai; Daniel Guénard; Marc Franck; Tri Mai Van; Christiane Gaspard; Thierry Sévenet
New cytotoxic cucurbitacins from the pericarps of Trichosanthes tricuspidata fruits.
Natural product letters 2002;16(1):15-9.
2001: L P Mai; Françoise Guéritte; Vincent Dumontet; MV Tri; B Hill; Odile Thoison; Daniel Guénard; Thierry Sévenet
Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis.
Journal of natural products 2001;64(9):1162-8.
2001: L Mercklé; Joëlle Dubois; E Place; Sylviane Thoret; Françoise Guéritte; Daniel Guénard; Christiane Poupat; Alain Ahond; Pierre Potier
Semisynthesis of D-ring modified taxoids: novel thia derivatives of docetaxel.
The Journal of organic chemistry 2001;66(15):5058-65.
2001: E Pasquinet; P Rocca; S Richalot; Françoise Guéritte; Daniel Guénard; A Godard; Francis Marsais; Guy Quéguiner
First total synthesis of phenylpyridine analogues of the antimitotic rhazinilam.
The Journal of organic chemistry 2001;66(8):2654-61.
2000: Olivier Baudoin; Daniel Guénard; Françoise Guéritte
Palladium-catalyzed borylation of ortho-substituted phenyl halides and application to the one-pot synthesis of 2,2'-disubstituted biphenyls.
The Journal of organic chemistry 2000;65(26):9268-71.
2000: Christiane Poupat; I Hook; Françoise Guéritte; Alain Ahond; Daniel Guénard; Marie-Thérèse Adeline; X P Wang; D Dempsey; S Breuillet; Pierre Potier
Neutral and basic taxoid contents in the needles of Taxus species.
Planta medica 2000;66(6):580-4.
2000: D Roux; Hamid A Hadi; Sylviane Thoret; Daniel Guénard; Odile Thoison; M Païs; Thierry Sévenet
Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system.
Journal of natural products 2000;63(8):1070-6.
2000: René Brecht; Gunther Seitz; Daniel Guénard; Sylviane Thoret
Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly.
Bioorganic & medicinal chemistry 2000;8(3):557-62.
2000: Daniel Guénard; Sylviane Thoret; Joëlle Dubois; Marie-Thérèse Adeline; Q Wang; Françoise Guéritte
Effects of the hydrophobicity of taxoids on their interaction with tubulin.
Bioorganic & medicinal chemistry 2000;8(1):145-56.
1999: C Dupont; Daniel Guénard; L Tchertanov; Sylviane Thoret; Françoise Guéritte
D-ring substituted rhazinilam analogues: semisynthesis and evaluation of antitubulin activity.
Bioorganic & medicinal chemistry 1999;7(12):2961-9.