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Peter Guengerich
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80
Shimada, Tsutomu
43
Yamazaki, H
28
Gillam, Elizabeth
17
Harris, Thomas
15
Eoff, Robert
15
Ueng, YF
14
Rizzo, Carmelo
14
Inoue, Kiyoshi
13
Martin, Martha
12
Johnson, William
11
Egli, Martin
11
Oda, Yoshimitsu
11
Zang, Hong
10
Parikh, A
10
Choi, Jeong-Yun
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All Publications
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2009: Wu Zhong-Liu; Qiao Jing; Zhang Zhi-Gang; Guengerich F Peter; Liu Yan; Pei Xiao-Qiong
Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression.
Biotechnology letters 2009;31(10):1589-93.
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2009: Deweese Joseph E; Guengerich F Peter; Burgin Alex B; Osheroff Neil
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.
Biochemistry 2009;48(38):8940-7.
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2009: Zhang Huidong; Bren Urban; Kozekov Ivan D; Rizzo Carmelo J; Stec Donald F; Guengerich F Peter
Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases.
Journal of molecular biology 2009;392(2):251-69.
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2009: Grobe Nadja; Zhang Baichen; Fisinger Ursula; Kutchan Toni M; Zenk Meinhart H; Guengerich F Peter
Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis.
The Journal of biological chemistry 2009;284(36):24425-31.
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2009: Irimia Adriana; Eoff Robert L; Guengerich F Peter; Egli Martin
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct.
The Journal of biological chemistry 2009;284(33):22467-80.
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2009: Eoff Robert L; Stafford Jennifer B; Szekely Jozsef; Rizzo Carmelo J; Egli Martin; Guengerich F Peter; Marnett Lawrence J
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2009;48(30):7079-88.
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2009: Shimada Tsutomu; Tanaka Katsuhiro; Takenaka Shigeo; Foroozesh Maryam K; Murayama Norie; Yamazaki Hiroshi; Guengerich F Peter; Komori Masayuki
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.
Chemical research in toxicology 2009;22(7):1325-33.
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2009: Eoff Robert L; Sanchez-Ponce Raymundo; Guengerich F Peter
Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4.
The Journal of biological chemistry 2009;284(31):21090-9.
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2009: Chowdhury Goutam; Guengerich F Peter
Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments.
Chemical research in toxicology 2009;22(7):1310-9.
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2009: Sangar Michelle Cook; Anandatheerthavarada Hindupur K; Tang Weigang; Prabu Subbuswamy K; Martin Martha V; Dostalek Miroslav; Guengerich F Peter; Avadhani Narayan G
Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism.
The FEBS journal 2009;276(13):3440-53.
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2009: Voehler Markus W; Eoff Robert L; McDonald W Hayes; Guengerich F Peter; Stone Michael P
Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.
The Journal of biological chemistry 2009;284(27):18434-44.
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2009: Guengerich F Peter
Thematic minireview series: metals in biology.
The Journal of biological chemistry 2009;284(28):18557.
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2009: Zhang Huidong; Eoff Robert L; Kozekov Ivan D; Rizzo Carmelo J; Egli Martin; Guengerich F Peter
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes.
The Journal of biological chemistry 2009;284(26):17687-99.
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2009: Christov Plamen P; Angel Karen C; Guengerich F Peter; Rizzo Carmelo J
Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry.
Chemical research in toxicology 2009;22(6):1086-95.
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2009: Choi Jeong-Yun; Lim Seonhee; Eoff Robert L; Guengerich F Peter
Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota.
Journal of molecular biology 2009;389(2):264-74.
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2009: Loecken Elisabeth M; Dasari Surendra; Hill Salisha; Tabb David L; Guengerich F Peter
The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems.
Chemical research in toxicology 2009;22(6):1069-76.
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2009: Brown Kyle L; Bren Urban; Stone Michael P; Guengerich F Peter
Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysis.
Chemical research in toxicology 2009;22(5):913-7.
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2009: Tang Zhongmei; Martin Martha V; Guengerich F Peter
Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches.
Analytical chemistry 2009;81(8):3071-8.
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2009: Guengerich F Peter
Introduction: Human metabolites in safety testing (MIST) issue.
Chemical research in toxicology 2009;22(2):237-8.
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2009: Knutson Charles G; Rubinson Emily H; Akingbade Dapo; Anderson Carolyn S; Stec Donald F; Petrova Katya V; Kozekov Ivan D; Guengerich F Peter; Rizzo Carmelo J; Marnett Lawrence J
Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.
Biochemistry 2009;48(4):800-9.
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2009: Zhang Huidong; Eoff Robert L; Kozekov Ivan D; Rizzo Carmelo J; Egli Martin; Guengerich F Peter
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts.
The Journal of biological chemistry 2009;284(6):3563-76.
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2009: Stafford Jennifer B; Eoff Robert L; Kozekova Albena; Rizzo Carmelo J; Guengerich F Peter; Marnett Lawrence J
Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one.
Biochemistry 2009;48(2):471-80.
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2009: Guengerich F Peter
Thematic series: metals in biology.
The Journal of biological chemistry 2009;284(2):709.
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2009: Cheng Qian; Sohl Christal D; Guengerich F Peter
High-throughput fluorescence assay of cytochrome P450 3A4.
Nature protocols 2009;4(9):1258-61.
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2009: Sohl Christal D; Cheng Qian; Guengerich F Peter
Chromatographic assays of drug oxidation by human cytochrome P450 3A4.
Nature protocols 2009;4(9):1252-7.
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2009: Guengerich F Peter; Martin Martha V; Sohl Christal D; Cheng Qian
Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase.
Nature protocols 2009;4(9):1245-51.
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2009: Nagashima Satomi; Shimizu Makiko; Yano Hiroshi; Murayama Norie; Kumai Toshio; Kobayashi Shinichi; Guengerich F Peter; Yamazaki Hiroshi
Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors.
Drug metabolism and pharmacokinetics 2009;24(3):218-25.
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2008: Shimada Tsutomu; Murajama Norie; Tanaka Katsuhiro; Takenaka Shigeo; Imai Yoshio; Hopkins Nancy E; Foroozesh Maryam K; Alworth Willam L; Yamazaki Hiroshi; Guengerich F Peter; Komori Masayuki
Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity.
Chemical research in toxicology 2008;21(12):2313-23.
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2008: Miyazaki Mitsue; Nakamura Katsunori; Fujita Yukiyoshi; Guengerich F Peter; Horiuchi Ryuya; Yamamoto Koujirou
Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2287-91.
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2008: Isin Emre M; Guengerich F Peter
Substrate binding to cytochromes P450.
Analytical and bioanalytical chemistry 2008;392(6):1019-30.
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2008: Fang Qingming; Noronha Anne M; Murphy Sebastian P; Wilds Christopher J; Tubbs Julie L; Tainer John A; Chowdhury Goutam; Guengerich F Peter; Pegg Anthony E
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 2008;47(41):10892-903.
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2008: Shanmugam Ganesh; Kozekov Ivan D; Guengerich F Peter; Rizzo Carmelo J; Stone Michael P
Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2.
Chemical research in toxicology 2008;21(9):1795-805.
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2008: Stark Katarina; Wu Zhong-Liu; Bartleson Cheryl J; Guengerich F Peter
mRNA distribution and heterologous expression of orphan cytochrome P450 20A1.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(9):1930-7.
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2008: Choi Jeong-Yun; Guengerich F Peter
Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1.
The Journal of biological chemistry 2008;283(35):23645-55.
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2008: Stark Katarina; Dostalek Miroslav; Guengerich F P
Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide.
The FEBS journal 2008;275(14):3706-17.
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2008: Dostalek Miroslav; Hardy Klarissa D; Milne Ginger L; Morrow Jason D; Chen Chi; Gonzalez Frank J; Gu Jun; Ding Xinxin; Johnson Delinda A; Johnson Jeffrey A; Martin Martha V; Guengerich F Peter
Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems.
The Journal of biological chemistry 2008;283(25):17147-57.
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2008: Bodreddigari Sridevi; Jones Laundette Knight; Egner Patricia A; Groopman John D; Sutter Carrie Hayes; Roebuck Bill D; Guengerich F Peter; Kensler Thomas W; Sutter Thomas R
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.
Chemical research in toxicology 2008;21(5):1134-42.
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2008: Isin Emre M; Sohl Christal D; Eoff Robert L; Guengerich F Peter
Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene.
Archives of biochemistry and biophysics 2008;473(1):69-75.
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2008: Sohl Christal D; Isin Emre M; Eoff Robert L; Marsch Glenn A; Stec Donald F; Guengerich F Peter
Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.
The Journal of biological chemistry 2008;283(11):7293-308.
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2008: Loecken Elisabeth M; Guengerich F Peter
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.
Chemical research in toxicology 2008;21(2):453-8.
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2008: Kim Dong-Hyun; Kim Keon-Hee; Isin Emre M; Guengerich F Peter; Chae Ho Zoon; Ahn Taeho; Yun Chul-Ho
Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli.
Protein expression and purification 2008;57(2):188-200.
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2008: Guengerich F Peter
Cytochrome p450 and chemical toxicology.
Chemical research in toxicology 2008;21(1):70-83.
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2008: Dimitri Alexandra; Goodenough Angela K; Guengerich F Peter; Broyde Suse; Scicchitano David A
Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase.
Journal of molecular biology 2008;375(2):353-66.
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2008: Chowdhury Goutam; Guengerich F Peter
Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry.
Angewandte Chemie (International ed. in English) 2008;47(2):381-4.
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2007: Lamb David C; Waterman Michael R; Kelly Steven L; Guengerich F Peter
Cytochromes P450 and drug discovery.
Current opinion in biotechnology 2007;18(6):504-12.
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2007: Irimia Adriana; Eoff Robert L; Pallan Pradeep S; Guengerich F Peter; Egli Martin
Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene.
The Journal of biological chemistry 2007;282(50):36421-33.
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2007: Dostalek Miroslav; Brooks Joshua D; Hardy Klarissa D; Milne Ginger L; Moore Megan M; Sharma Sameer; Morrow Jason D; Guengerich F Peter
In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers.
Molecular pharmacology 2007;72(6):1419-24.
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2007: Shanmugam Ganesh; Goodenough Angela K; Kozekov Ivan D; Guengerich F Peter; Rizzo Carmelo J; Stone Michael P
Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6.
Chemical research in toxicology 2007;20(11):1601-11.
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2007: Watanabe Kengo; Liberman Rosa G; Skipper Paul L; Tannenbaum Steven R; Guengerich F Peter
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates.
Chemical research in toxicology 2007;20(11):1594-600.
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2007: Bren Urban; Guengerich F Peter; Mavri Janez
Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations.
Chemical research in toxicology 2007;20(8):1134-40.
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2007: Amunom Immaculate; Stephens Laura J; Tamasi Viola; Cai Jian; Pierce William M; Conklin Daniel J; Bhatnagar Aruni; Srivastava S; Martin Martha V; Guengerich F Peter; Prough Russell A
Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes.
Archives of biochemistry and biophysics 2007;464(2):187-96.
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2007: Eoff Robert L; Irimia Adriana; Angel Karen C; Egli Martin; Guengerich F Peter
Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4.
The Journal of biological chemistry 2007;282(27):19831-43.
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2007: Chun Young-Jin; Shimada Tsutomu; Sanchez-Ponce Raymundo; Martin Martha V; Lei Li; Zhao Bin; Kelly Steven L; Waterman Michael R; Lamb David C; Guengerich F Peter
Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2).
The Journal of biological chemistry 2007;282(24):17486-500.
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2007: Sanchez-Ponce Raymundo; Guengerich F Peter
Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes.
Analytical chemistry 2007;79(9):3355-62.
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2007: Eoff Robert L; Angel Karen C; Egli Martin; Guengerich F Peter
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing.
The Journal of biological chemistry 2007;282(18):13573-84.
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2007: Guengerich F Peter; MacDonald James S
Applying mechanisms of chemical toxicity to predict drug safety.
Chemical research in toxicology 2007;20(3):344-69.
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2007: Shimada Tsutomu; Murayama Norie; Okada Kazushi; Funae Yoshihiko; Yamazaki Hiroshi; Guengerich F Peter
Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.
Chemical research in toxicology 2007;20(3):489-96.
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2007: Isin Emre M; Guengerich F Peter
Complex reactions catalyzed by cytochrome P450 enzymes.
Biochimica et biophysica acta 2007;1770(3):314-29.
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2007: Isin Emre M; Guengerich F Peter
Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4.
The Journal of biological chemistry 2007;282(9):6863-74.
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2007: Liu Liping; Watanabe Kengo; Fang Qingming; Williams Kevin M; Guengerich F Peter; Pegg Anthony E
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Chemical research in toxicology 2007;20(1):155-63.
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2007: Warzecha Heribert; Frank Andreas; Peer Markus; Gillam Elizabeth M J; Guengerich F Peter; Unger Matthias
Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures.
Plant biotechnology journal 2007;5(1):185-91.
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2007: Eoff Robert L; Irimia Adriana; Egli Martin; Guengerich F Peter
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred.
The Journal of biological chemistry 2007;282(2):1456-67.
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2007: Guengerich F Peter
Mechanisms of cytochrome P450 substrate oxidation: MiniReview.
Journal of biochemical and molecular toxicology 2007;21(4):163-8.
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2007: Stark Katarina; Guengerich F Peter
Characterization of orphan human cytochromes P450.
Drug metabolism reviews 2007;39(2-3):627-37.
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2006: Choi Jeong-Yun; Chowdhury Goutam; Zang Hong; Angel Karen C; Vu Choua C; Peterson Lisa A; Guengerich F Peter
Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases.
The Journal of biological chemistry 2006;281(50):38244-56.
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2006: Stover James S; Chowdhury Goutam; Zang Hong; Guengerich F Peter; Rizzo Carmelo J
Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases.
Chemical research in toxicology 2006;19(11):1506-17.
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2006: Oda Yoshimitsu; Totsuka Yukari; Wakabayashi Keiji; Guengerich F Peter; Shimada Tsutomu
Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains.
Mutagenesis 2006;21(6):411-6.
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2006: Guengerich F Peter
A malleable catalyst dominates the metabolism of drugs.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13565-6.
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2006: Choi Jeong-Yun; Stover James S; Angel Karen C; Chowdhury Goutam; Rizzo Carmelo J; Guengerich F Peter
Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site.
The Journal of biological chemistry 2006;281(35):25297-306.
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2006: Watanabe Kengo; Guengerich F Peter
Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane.
Chemical research in toxicology 2006;19(8):1091-6.
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2006: Choi Jeong-Yun; Angel Karen C; Guengerich F Peter
Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa.
The Journal of biological chemistry 2006;281(30):21062-72.
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2006: Choi Jeong-Yun; Zang Hong; Angel Karen C; Kozekov Ivan D; Goodenough Angela K; Rizzo Carmelo J; Guengerich F Peter
Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases.
Chemical research in toxicology 2006;19(6):879-86.
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2006: Zang Hong; Chowdhury Goutam; Angel Karen C; Harris Thomas M; Guengerich F Peter
Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4.
Chemical research in toxicology 2006;19(6):859-67.
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2006: Wu Zhong-Liu; Sohl Christal D; Shimada Tsutomu; Guengerich F Peter
Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1.
Molecular pharmacology 2006;69(6):2007-14.
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2006: Bren Urban; Zupan Mateja; Guengerich F Peter; Mavri Janez
Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and guanine.
The Journal of organic chemistry 2006;71(11):4078-84.
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2006: Irimia Adriana; Zang Hong; Loukachevitch Lioudmila V; Eoff Robert L; Guengerich F Peter; Egli Martin
Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4.
Biochemistry 2006;45(19):5949-56.
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2006: Kim Keon-Hee; Isin Emre M; Yun Chul-Ho; Kim Dong-Hyun; Guengerich F P
Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.
The FEBS journal 2006;273(10):2223-31.
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2006: Jiang Zhengwen; Dragin Nadine; Jorge-Nebert Lucia F; Martin Martha V; Guengerich F Peter; Aklillu Eleni; Ingelman-Sundberg Magnus; Hammons George J; Lyn-Cook Beverly D; Kadlubar Fred F; Saldana Shannon N; Sorter Michael; Vinks Alexander A; Nassr Nassr; von Richter Oliver; Jin Li; Nebert Daniel W
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.
Pharmacogenetics and genomics 2006;16(5):359-67.
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2006: Choi Jeong-Yun; Guengerich F Peter
Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota.
The Journal of biological chemistry 2006;281(18):12315-24.
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2006: Isin Emre M; Guengerich F Peter
Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.
The Journal of biological chemistry 2006;281(14):9127-36.
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2006: Lamb David C; Guengerich F Peter; Kelly Steven L; Waterman Michael R
Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery.
Expert opinion on drug metabolism & toxicology 2006;2(1):27-40.
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2006: Shimada Tsutomu; Guengerich F Peter
Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons.
Chemical research in toxicology 2006;19(2):288-94.
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2006: Guengerich F Peter
Interactions of carcinogen-bound DNA with individual DNA polymerases.
Chemical reviews 2006;106(2):420-52.
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2006: Wu Zhong-Liu; Bartleson Cheryl J; Ham Amy-Joan L; Guengerich F Peter
Heterologous expression, purification, and properties of human cytochrome P450 27C1.
Archives of biochemistry and biophysics 2006;445(1):138-46.
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2006: Zang Hong; Irimia Adriana; Choi Jeong-Yun; Angel Karen C; Loukachevitch Lioudmila V; Egli Martin; Guengerich F Peter
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4.
The Journal of biological chemistry 2006;281(4):2358-72.
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2006: Guengerich F Peter; Martin Martha V
Purification of cytochromes P450: products of bacterial recombinant expression systems.
Methods in molecular biology (Clifton, N.J.) 2006;320():31-7.
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2006: Guengerich F Peter
Cytochrome P450s and other enzymes in drug metabolism and toxicity.
The AAPS journal 2006;8(1):E101-11.
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2005: Zhao Bin; Guengerich F Peter; Voehler Markus; Waterman Michael R
Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer.
The Journal of biological chemistry 2005;280(51):42188-97.
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2005: Wu Zhong-Liu; Podust Larissa M; Guengerich F Peter
Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis.
The Journal of biological chemistry 2005;280(49):41090-100.
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2005: Kim Donghak; Wu Zhong-Liu; Guengerich F Peter
Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.
The Journal of biological chemistry 2005;280(48):40319-27.
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2005: Guengerich F Peter; Wu Zhong-Liu; Bartleson Cheryl J
Function of human cytochrome P450s: characterization of the orphans.
Biochemical and biophysical research communications 2005;338(1):465-9.
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2005: Goodenough Angela K; Kozekov Ivan D; Zang Hong; Choi Jeong-Yun; Guengerich F Peter; Harris Thomas M; Rizzo Carmelo J
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.
Chemical research in toxicology 2005;18(11):1701-14.
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2005: Guengerich F Peter
How I became a biochemist.
IUBMB life 2005;57(10):705-7.
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2005: Choi Jeong-Yun; Guengerich F Peter
Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta.
Journal of molecular biology 2005;352(1):72-90.
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2005: Zang Hong; Fang Qingming; Pegg Anthony E; Guengerich F Peter
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.
The Journal of biological chemistry 2005;280(35):30873-81.
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2005: Guengerich F Peter
Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase.
Archives of biochemistry and biophysics 2005;440(2):204-11.
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2005: Zang Hong; Goodenough Angela K; Choi Jeong-Yun; Irimia Adriana; Loukachevitch Lioudmila V; Kozekov Ivan D; Angel Karen C; Rizzo Carmelo J; Egli Martin; Guengerich F Peter
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.
The Journal of biological chemistry 2005;280(33):29750-64.
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2005: Liebler Daniel C; Guengerich F Peter
Elucidating mechanisms of drug-induced toxicity.
Nature reviews. Drug discovery 2005;4(5):410-20.
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2005: Krauser Joel A; Guengerich F Peter
Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.
The Journal of biological chemistry 2005;280(20):19496-506.
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2005: Dueckershoff Katharina; Unger Matthias; Frank Andreas; Gillam Elizabeth M J; Guengerich F Peter; Warzecha Heribert
Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA.
FEBS letters 2005;579(11):2480-4.
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2005: VanderVeen Laurie A; Druckova Alexandra; Riggins James N; Sorrells Jennifer L; Guengerich F Peter; Marnett Lawrence J
Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2005;44(13):5024-33.
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2005: Yun Chul-Ho; Kim Keon-Hee; Calcutt M Wade; Guengerich F Peter
Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.
The Journal of biological chemistry 2005;280(13):12279-91.
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2005: Vélez-Cruz Renier; Riggins James N; Daniels J Scott; Cai Hongliang; Guengerich F Peter; Marnett Lawrence J; Osheroff Neil
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
Biochemistry 2005;44(10):3972-81.
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2005: Shimada Tsutomu; Mernaugh Raymond L; Guengerich F Peter
Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes.
Archives of biochemistry and biophysics 2005;435(1):207-16.
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2005: Zhao Bin; Guengerich F Peter; Bellamine Aouatef; Lamb David C; Izumikawa Miho; Lei Li; Podust Larissa M; Sundaramoorthy Munirathinam; Kalaitzis John A; Reddy L Manmohan; Kelly Steven L; Moore Bradley S; Stec Donald; Voehler Markus; Falck John R; Shimada Tsutomu; Waterman Michael R
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.
The Journal of biological chemistry 2005;280(12):11599-607.
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2005: Zang Hong; Harris Thomas M; Guengerich F Peter
Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase.
Chemical research in toxicology 2005;18(2):389-400.
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2005: Wu Zhongliu-Liu; Aryal Pramod; Lozach Olivier; Meijer Laurent; Guengerich F Peter
Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.
Chemistry & biodiversity 2005;2(1):51-65.
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2005: Guengerich F Peter
Life and times in biochemical toxicology.
International journal of toxicology 2005;24(1):5-21.
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2005: Guengerich F Peter
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation.
Archives of biochemistry and biophysics 2005;433(2):369-78.
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2005: Zang Hong; Harris Thomas M; Guengerich F Peter
Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase.
The Journal of biological chemistry 2005;280(2):1165-78.
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2005: Guengerich F Peter
Activation of alkyl halides by glutathione transferases.
Methods in enzymology 2005;401():342-53.
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2005: Guengerich F Peter
Generation of reactive intermediates.
Journal of biochemical and molecular toxicology 2005;19(3):173-4.
-
2005: Kim Donghak; Guengerich F Peter
Cytochrome P450 activation of arylamines and heterocyclic amines.
Annual review of pharmacology and toxicology 2005;45():27-49.
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2004: Kim Donghak; Guengerich F Peter
Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding.
Archives of biochemistry and biophysics 2004;432(1):102-8.
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2004: Kim Eun-Young; Kim Joon-Sik; Kim Min-Young; Koh Woo-Suk; Guengerich F Peter; Yun Chul-Ho
Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin.
Toxicology letters 2004;153(2):239-46.
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2004: Guengerich F Peter
Where is toxicology headed in the future?
Drug metabolism reviews 2004;36(3-4):475-86.
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2004: Krauser Joel A; Voehler Markus; Tseng Li-Hong; Schefer Alexandre B; Godejohann Markus; Guengerich F Peter
Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.
European journal of biochemistry / FEBS 2004;271(19):3962-9.
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2004: Kim James H; Sherman Mark E; Curriero Frank C; Guengerich F Peter; Strickland Paul T; Sutter Thomas R
Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers.
Toxicology and applied pharmacology 2004;199(3):210-9.
-
2004: Guengerich F Peter; Krauser Joel A; Johnson William W
Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2.
Biochemistry 2004;43(33):10775-88.
-
2004: Sun Yuan-Wan; Guengerich F Peter; Sharma Arun K; Boyiri Telih; Amin Shantu; el-Bayoumy Karam
Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines.
Chemical research in toxicology 2004;17(8):1077-85.
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2004: Valadez J Gerardo; Liu Liping; Loktionova Natalia A; Pegg Anthony E; Guengerich F Peter
Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
Chemical research in toxicology 2004;17(7):972-82.
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2004: Liu Liping; Williams Kevin M; Guengerich F Peter; Pegg Anthony E
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
Chemical research in toxicology 2004;17(6):742-52.
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2004: Guengerich F Peter; Sorrells Jennifer L; Schmitt Sophie; Krauser Joel A; Aryal Pramod; Meijer Laurent
Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.
Journal of medicinal chemistry 2004;47(12):3236-41.
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2004: Vaclavikova Radka; Soucek Pavel; Svobodova Lenka; Anzenbacher Pavel; Simek Petr; Guengerich F Peter; Gut Ivan
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):666-74.
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2004: Galijatovic Alema; Beaton Deirdre; Nguyen Nghia; Chen Shujuan; Bonzo Jessica; Johnson Randall; Maeda Shin; Karin Michael; Guengerich F Peter; Tukey Robert H
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice.
The Journal of biological chemistry 2004;279(23):23969-76.
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2004: Guengerich F Peter
Cytochrome P450: what have we learned and what are the future issues?
Drug metabolism reviews 2004;36(2):159-97.
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2004: Kim Donghak; Kadlubar Fred F; Teitel Candee H; Guengerich F Peter
Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines.
Chemical research in toxicology 2004;17(4):529-36.
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2004: Andrieux Lise; Langouët Sophie; Fautrel Alain; Ezan Fréderic; Krauser Joel A; Savouret Jean F; Guengerich F Peter; Baffet Georges; Guillouzo André
Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes.
Molecular pharmacology 2004;65(4):934-43.
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2004: Choi Jeong-Yun; Guengerich F Peter
Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase.
The Journal of biological chemistry 2004;279(18):19217-29.
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2004: Valadez J Gerardo; Guengerich F Peter
S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair rates more than sites of initial dna damage.
The Journal of biological chemistry 2004;279(14):13435-46.
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2004: Kim Donghak; Guengerich F Peter
Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation.
Biochemistry 2004;43(4):981-8.
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2004: Zhou Huijia; Josephy P David; Kim Donghak; Guengerich F Peter
Functional characterization of four allelic variants of human cytochrome P450 1A2.
Archives of biochemistry and biophysics 2004;422(1):23-30.
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2004: Liu Liping; Hachey David L; Valadez Gerardo; Williams Kevin M; Guengerich F Peter; Loktionova Natalia A; Kanugula Sreenivas; Pegg Anthony E
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
The Journal of biological chemistry 2004;279(6):4250-9.
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2004: Marsch Glenn A; Botta Sisir; Martin Martha V; McCormick W Andrew; Guengerich F Peter
Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes.
Chemical research in toxicology 2004;17(1):45-54.
-
2003: Guengerich F Peter; McCormick W Andrew; Wheeler James B
Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases.
Chemical research in toxicology 2003;16(11):1493-9.
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2003: Kiyotani Kazuma; Yamazaki Hiroshi; Fujieda Masaki; Iwano Shunsuke; Matsumura Keiko; Satarug Soisungwan; Ujjin Pailin; Shimada Tsutomu; Guengerich F Peter; Parkinson Andrew; Honda Goro; Nakagawa Kazuko; Ishizaki Takashi; Kamataki Tetsuya
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).
Pharmacogenetics 2003;13(11):689-95.
-
2003: Kimzey Amy L; Weitz Karl K; Guengerich F Peter; Zangar Richard C
Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate.
Biochemistry 2003;42(43):12691-9.
-
2003: Guengerich F Peter; Fang Qingming; Liu Liping; Hachey David L; Pegg Anthony E
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
Biochemistry 2003;42(37):10965-70.
-
2003: Guengerich F Peter
Cytochromes P450, drugs, and diseases.
Molecular interventions 2003;3(4):194-204.
-
2003: Guengerich F Peter; Hanna Imad H; Martin Martha V; Gillam Elizabeth M J
Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
Biochemistry 2003;42(5):1245-53.
-
2003: Yun Chul-Ho; Lee Hye Suk; Lee Hee-Yong; Yim Sung-Kun; Kim Keon-Hee; Kim Eunhee; Yea Sung-Su; Guengerich F Peter
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin.
Toxicology letters 2003;137(3):143-50.
-
2003: Guengerich F Peter
Activation of dihaloalkanes by thiol-dependent mechanisms.
Journal of biochemistry and molecular biology 2003;36(1):20-7.
-
2003: Guengerich F Peter
Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions.
Archives of biochemistry and biophysics 2003;409(1):59-71.
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2002: Guengerich F Peter; Wheeler James B; Chun Young-Jin; Kim Donghak; Shimada Tsutomu; Aryal Pramod; Oda Yoshimitsu; Gillam Elizabeth M J
Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays.
Toxicology 2002;181-182():261-4.
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2002: Yoshioka Tadao; Krauser Joel A; Guengerich F Peter
Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide.
Chemical research in toxicology 2002;15(11):1414-20.
-
2002: Guengerich F Peter
Rate-limiting steps in cytochrome P450 catalysis.
Biological chemistry 2002;383(10):1553-64.
-
2002: Liu Liping; Pegg Anthony E; Williams Kevin M; Guengerich F Peter
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
The Journal of biological chemistry 2002;277(40):37920-8.
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2002: Turesky Robert J; Guengerich F Peter; Guillouzo André; Langouët Sophie
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.
Mutation research 2002;506-507():187-95.
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2002: Guengerich F Peter; Miller Grover P; Hanna Imad H; Martin Martha V; Léger Serge; Black Cameron; Chauret Nathalie; Silva José M; Trimble Laird A; Yergey James A; Nicoll-Griffith Deborah A
Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
Biochemistry 2002;41(36):11025-34.
-
2002: Guengerich F Peter; Miller Grover P; Hanna Imad H; Sato Hideaki; Martin Martha V
Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.
The Journal of biological chemistry 2002;277(37):33711-9.
-
2002: Guengerich F Peter
N-hydroxyarylamines.
Drug metabolism reviews 2002;34(3):607-23.
-
2002: Yoshioka Tadao; Krauser Joel A; Guengerich F Peter
Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine.
Chemical research in toxicology 2002;15(8):1096-105.
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2002: Saparbaev Murat; Langouët Sophie; Privezentzev Cyril V; Guengerich F Peter; Cai Hongliang; Elder Rhoderick H; Laval Jacques
1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase.
The Journal of biological chemistry 2002;277(30):26987-93.
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2002: Guengerich F Peter; Voehler Markus; Williams Kevin M; Deng Zhengwu; Harris Thomas M
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine.
Chemical research in toxicology 2002;15(6):793-8.
-
2002: Guengerich F Peter; Arneson Kyle O; Williams Kevin M; Deng Zhengwu; Harris Thomas M
Reaction of aflatoxin B(1) oxidation products with lysine.
Chemical research in toxicology 2002;15(6):780-92.
-
2002: Guengerich F Peter
Cytochrome P450 enzymes in the generation of commercial products.
Nature reviews. Drug discovery 2002;1(5):359-66.
-
2002: Yamazaki Hiroshi; Nakamura Mami; Komatsu Tomoko; Ohyama Katsuhiro; Hatanaka Naoya; Asahi Satoru; Shimada Noriaki; Guengerich F Peter; Shimada Tsutomu; Nakajima Miki; Yokoi Tsuyoshi
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Protein expression and purification 2002;24(3):329-37.
-
2002: Ueng Yune-Fang; Jan Woan-Ching; Lin Lie-Chwen; Chen Ta-Liang; Guengerich F Peter; Chen Chieh-Fu
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):349-53.
-
2002: Guengerich F Peter
Update information on human P450s.
Drug metabolism reviews 2002;34(1-2):7-15.
-
2002: Woodside Adrienne M; Guengerich F Peter
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes.
Biochemistry 2002;41(3):1039-50.
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2002: Woodside Adrienne M; Guengerich F Peter
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine.
Biochemistry 2002;41(3):1027-38.
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2002: Kiyotani Kazuma; Fujieda Masaki; Yamazaki Hiroshi; Shimada Tsutomu; Guengerich F Peter; Parkinson Andrew; Nakagawa Kazuko; Ishizaki Takashi; Kamataki Tetsuya
Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians.
Drug metabolism and pharmacokinetics 2002;17(5):482-7.
-
2002: Kim Donghak; Guengerich F Peter
Random mutagenesis by whole-plasmid PCR amplification.
Methods in molecular biology (Clifton, N.J.) 2002;192():241-5.
-
2001: Gillam E M; Guengerich F P
Exploiting the versatility of human cytochrome P450 enzymes: the promise of blue roses from biotechnology.
IUBMB life 2001;52(6):271-7.
-
2001: Miller G P; Hanna I H; Nishimura Y; Guengerich F P
Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis.
Biochemistry 2001;40(47):14215-23.
-
2001: Nakamura K; Martin M V; Guengerich F P
Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products.
Archives of biochemistry and biophysics 2001;395(1):25-31.
-
2001: Hatanaka N; Yamazaki H; Oda Y; Guengerich F P; Nakajima M; Yokoi T
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay.
Mutation research 2001;497(1-2):223-33.
-
2001: Hanna I H; Krauser J A; Cai H; Kim M S; Guengerich F P
Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.
The Journal of biological chemistry 2001;276(43):39553-61.
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2001: Hanna I H; Kim M S; Guengerich F P
Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity.
Archives of biochemistry and biophysics 2001;393(2):255-61.
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2001: Shimada T; Oda Y; Gillam E M; Guengerich F P; Inoue K
Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(9):1176-82.
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2001: Wheeler J B; Stourman N V; Thier R; Dommermuth A; Vuilleumier S; Rose J A; Armstrong R N; Guengerich F P
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalomethanes.
Chemical research in toxicology 2001;14(8):1118-27.
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2001: Wheeler J B; Stourman N V; Armstrong R N; Guengerich F P
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal dihaloethanes.
Chemical research in toxicology 2001;14(8):1107-17.
-
2001: Yamazaki H; Shimada T; Martin M V; Guengerich F P
Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.
The Journal of biological chemistry 2001;276(33):30885-91.
-
2001: Turesky R J; Parisod V; Huynh-Ba T; Langouët S; Guengerich F P
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.
Chemical research in toxicology 2001;14(7):901-11.
-
2001: Guengerich F P
Forging the links between metabolism and carcinogenesis.
Mutation research 2001;488(3):195-209.
-
2001: Guengerich F P
Uncommon P450-catalyzed reactions.
Current drug metabolism 2001;2(2):93-115.
-
2001: Guengerich F P; Cai H; McMahon M; Hayes J D; Sutter T R; Groopman J D; Deng Z; Harris T M
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.
Chemical research in toxicology 2001;14(6):727-37.
-
2001: Guengerich F P
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.
Chemical research in toxicology 2001;14(6):611-50.
-
2001: Miller G P; Guengerich F P
Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: evidence for two binding sites.
Biochemistry 2001;40(24):7262-72.
-
2001: Yueh M F; Nguyen N; Famourzadeh M; Strassburg C P; Oda Y; Guengerich F P; Tukey R H
The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Carcinogenesis 2001;22(6):943-50.
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2001: Oda Y; Aryal P; Terashita T; Gillam E M; Guengerich F P; Shimada T
Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase.
Mutation research 2001;492(1-2):81-90.
-
2001: Marsch G A; Mundkowski R G; Morris B J; Manier M L; Hartman M K; Guengerich F P
Characterization of nucleoside and DNA adducts formed by S-(1-acetoxymethyl)glutathione and implications for dihalomethane-glutathione conjugates.
Chemical research in toxicology 2001;14(5):600-8.
-
2001: Nakamura K; Hanna I H; Cai H; Nishimura Y; Williams K M; Guengerich F P
Coumarin substrates for cytochrome P450 2D6 fluorescence assays.
Analytical biochemistry 2001;292(2):280-6.
-
2001: Cai H; Guengerich F P
Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification.
Chemical research in toxicology 2001;14(4):451-8.
-
2001: Yun C H; Miller G P; Guengerich F P
Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis.
Biochemistry 2001;40(14):4521-30.
-
2001: Shimada T; Watanabe J; Inoue K; Guengerich F P; Gillam E M
Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(3):163-76.
-
2001: Shimada T; Tsumura F; Yamazaki H; Guengerich F P; Inoue K
Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.
Pharmacogenetics 2001;11(2):143-56.
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2001: Langouët S; Welti D H; Kerriguy N; Fay L B; Huynh-Ba T; Markovic J; Guengerich F P; Guillouzo A; Turesky R J
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.
Chemical research in toxicology 2001;14(2):211-21.
-
2001: Einolf H J; Guengerich F P
Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysis.
The Journal of biological chemistry 2001;276(6):3764-71.
-
2001: Cai H; Guengerich F P
Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions.
Chemical research in toxicology 2001;14(1):54-61.
-
2001: Gautier J; Richoz J; Welti D H; Markovic J; Gremaud E; Guengerich F P; Turesky R J
Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes.
Chemical research in toxicology 2001;14(1):34-45.
-
2001: Guengerich F P; Cai H; Johnson W W; Parikh A
Reactive intermediates in biological systems: what have we learned and where are we going?
Advances in experimental medicine and biology 2001;500():639-50.
-
2001: Langouët S; Welti D H; Kerriguy N; Fay L B; Guengerich F P; Guillouzo A; Turesky R J
Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes.
Advances in experimental medicine and biology 2001;500():459-62.
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2000: Yamazaki H; Hatanaka N; Kizu R; Hayakawa K; Shimada N; Guengerich F P; Nakajima M; Yokoi T
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.
Mutation research 2000;472(1-2):129-38.
-
2000: Gillam E M; Notley L M; Cai H; De Voss J J; Guengerich F P
Oxidation of indole by cytochrome P450 enzymes.
Biochemistry 2000;39(45):13817-24.
-
2000: Komatsu T; Yamazaki H; Asahi S; Gillam E M; Guengerich F P; Nakajima M; Yokoi T
Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(11):1361-8.
-
2000: Shimada T; Tsumura F; Gillam E M; Guengerich F P; Inoue K
Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli.
Protein expression and purification 2000;20(1):73-80.
-
2000: Yun C H; Miller G P; Guengerich F P
Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.
Biochemistry 2000;39(37):11319-29.
-
2000: Guengerich F P; Parikh A; Yun C H; Kim D; Nakamura K; Notley L M; Gillam E M
What makes P450s work? Searches for answers with known and new P450s.
Drug metabolism reviews 2000;32(3-4):267-81.
-
2000: Wandel C; Kim R B; Guengerich F P; Wood A J
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):895-8.
-
2000: Hanna I H; Dawling S; Roodi N; Guengerich F P; Parl F F
Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity.
Cancer research 2000;60(13):3440-4.
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2000: Hosea N A; Miller G P; Guengerich F P
Elucidation of distinct ligand binding sites for cytochrome P450 3A4.
Biochemistry 2000;39(20):5929-39.
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2000: Cai H; Guengerich F P
Acylation of protein lysines by trichloroethylene oxide.
Chemical research in toxicology 2000;13(5):327-35.
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2000: Einolf H J; Guengerich F P
Kinetic analysis of nucleotide incorporation by mammalian DNA polymerase delta.
The Journal of biological chemistry 2000;275(21):16316-22.
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2000: Langouët S; Furge L L; Kerriguy N; Nakamura K; Guillouzo A; Guengerich F P
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Chemical research in toxicology 2000;13(4):245-52.
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2000: Plastaras J P; Guengerich F P; Nebert D W; Marnett L J
Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.
The Journal of biological chemistry 2000;275(16):11784-90.
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2000: Hanna I H; Reed J R; Guengerich F P; Hollenberg P F
Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver.
Archives of biochemistry and biophysics 2000;376(1):206-16.
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2000: Guengerich F P
Metabolism of chemical carcinogens.
Carcinogenesis 2000;21(3):345-51.
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2000: Aryal P; Terashita T; Guengerich F P; Shimada T; Oda Y
Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay.
Environmental and molecular mutagenesis 2000;36(2):121-6.
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1999: Gillam E M; Aguinaldo A M; Notley L M; Kim D; Mundkowski R G; Volkov A A; Arnold F H; Soucek P; DeVoss J J; Guengerich F P
Formation of indigo by recombinant mammalian cytochrome P450.
Biochemical and biophysical research communications 1999;265(2):469-72.
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1999: Yamazaki H; Shibata A; Suzuki M; Nakajima M; Shimada N; Guengerich F P; Yokoi T
Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(11):1260-6.
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1999: Josephy P D; Evans D H; Williamson V; Henry T; Guengerich F P
Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines.
Mutation research 1999;429(2):199-208.
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1999: Guengerich F P; Mundkowski R G; Voehler M; Kadlubar F F
Formation and reactions of N(7)-aminoguanosine and derivatives.
Chemical research in toxicology 1999;12(10):906-16.
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1999: Turesky R J; Constable A; Fay L B; Guengerich F P
Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2.
Cancer letters 1999;143(2):109-12.
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1999: Yamazaki H; Nakajima M; Nakamura M; Asahi S; Shimada N; Gillam E M; Guengerich F P; Shimada T; Yokoi T
Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(9):999-1004.
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1999: Bell-Parikh L C; Guengerich F P
Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde.
The Journal of biological chemistry 1999;274(34):23833-40.
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1999: Shimada T; Watanabe J; Kawajiri K; Sutter T R; Guengerich F P; Gillam E M; Inoue K
Catalytic properties of polymorphic human cytochrome P450 1B1 variants.
Carcinogenesis 1999;20(8):1607-13.
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1999: Guengerich F P; Parikh A; Turesky R J; Josephy P D
Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype.
Mutation research 1999;428(1-2):115-24.
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1999: Shimada T; Gillam E M; Oda Y; Tsumura F; Sutter T R; Guengerich F P; Inoue K
Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.
Chemical research in toxicology 1999;12(7):623-9.
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1999: Aryal P; Yoshikawa K; Terashita T; Guengerich F P; Shimada T; Oda Y
Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase.
Mutation research 1999;442(2):113-20.
-
1999: Akasaka S; Guengerich F P
Mutagenicity of site-specifically located 1,N2-ethenoguanine in Chinese hamster ovary cell chromosomal DNA.
Chemical research in toxicology 1999;12(6):501-7.
-
1999: Parikh A; Josephy P D; Guengerich F P
Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties.
Biochemistry 1999;38(17):5283-9.
-
1999: Furge L L; Guengerich F P
Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex.
Biochemistry 1999;38(15):4818-25.
-
1999: Guengerich F P; Johnson W W
Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication.
Drug metabolism reviews 1999;31(1):141-58.
-
1999: Guengerich F P
The Vanderbilt University Center in Molecular Toxicology: the first 30 years.
Drug metabolism reviews 1999;31(1):1-11.
-
1999: Guengerich F P; Langouët S; Mican A N; Akasaka S; Müller M; Persmark M
Formation of etheno adducts and their effects on DNA polymerases.
IARC scientific publications 1999;(150):137-45.
-
1999: Guengerich F P
Cytochrome P-450 3A4: regulation and role in drug metabolism.
Annual review of pharmacology and toxicology 1999;39():1-17.
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1998: Guengerich F P; Hosea N A; Parikh A; Bell-Parikh L C; Johnson W W; Gillam E M; Shimada T
Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(12):1175-8.
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1998: Shimada T; Yamazaki H; Foroozesh M; Hopkins N E; Alworth W L; Guengerich F P
Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.
Chemical research in toxicology 1998;11(9):1048-56.
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1998: Einolf H J; Schnetz-Boutaud N; Guengerich F P
Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases.
Biochemistry 1998;37(38):13300-12.
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1998: Shimada T; Wunsch R M; Hanna I H; Sutter T R; Guengerich F P; Gillam E M
Recombinant human cytochrome P450 1B1 expression in Escherichia coli.
Archives of biochemistry and biophysics 1998;357(1):111-20.
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1998: Turesky R J; Constable A; Richoz J; Varga N; Markovic J; Martin M V; Guengerich F P
Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.
Chemical research in toxicology 1998;11(8):925-36.
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1998: Yamazaki H; Inoue K; Chiba K; Ozawa N; Kawai T; Suzuki Y; Goldstein J A; Guengerich F P; Shimada T
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes.
Biochemical pharmacology 1998;56(2):243-51.
-
1998: Guengerich F P
The Environmental Genome Project: functional analysis of polymorphisms.
Environmental health perspectives 1998;106(7):365-8.
-
1998: Guengerich F P; Johnson W W; Shimada T; Ueng Y F; Yamazaki H; Langouët S
Activation and detoxication of aflatoxin B1.
Mutation research 1998;402(1-2):121-8.
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1998: Yamazaki H; Shaw P M; Guengerich F P; Shimada T
Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes.
Chemical research in toxicology 1998;11(6):659-65.
-
1998: Guengerich F P; Shimada T
Activation of procarcinogens by human cytochrome P450 enzymes.
Mutation research 1998;400(1-2):201-13.
-
1998: Hosea N A; Guengerich F P
Oxidation of nonionic detergents by cytochrome P450 enzymes.
Archives of biochemistry and biophysics 1998;353(2):365-73.
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1998: Kim M S; Guengerich F P
Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione.
Chemical research in toxicology 1998;11(4):311-6.
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1998: Langouët S; Mican A N; Müller M; Fink S P; Marnett L J; Muhle S A; Guengerich F P
Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine.
Biochemistry 1998;37(15):5184-93.
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1998: Furge L L; Guengerich F P
Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-.
Biochemistry 1998;37(10):3567-74.
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1998: Josephy P D; Evans D H; Parikh A; Guengerich F P
Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli.
Chemical research in toxicology 1998;11(1):70-4.
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1998: Guengerich F P; Hosea N A; Martin M V
Purification of cytochromes P450: products of bacterial recombinant expression systems.
Methods in molecular biology (Clifton, N.J.) 1998;107():77-83.
-
1998: Guengerich F P; Martin M V
Purification of cytochromes P450. Rat and human hepatic forms.
Methods in molecular biology (Clifton, N.J.) 1998;107():35-53.
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1997: Guengerich F P; Johnson W W
Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.
Biochemistry 1997;36(48):14741-50.
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1997: Bell L C; Guengerich F P
Oxidation kinetics of ethanol by human cytochrome P450 2E1. Rate-limiting product release accounts for effects of isotopic hydrogen substitution and cytochrome b5 on steady-state kinetics.
The Journal of biological chemistry 1997;272(47):29643-51.
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1997: Shimada T; El-Bayoumy K; Upadhyaya P; Sutter T R; Guengerich F P; Yamazaki H
Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds.
Cancer research 1997;57(21):4757-64.
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1997: Yamazaki H; Inoue K; Shaw P M; Checovich W J; Guengerich F P; Shimada T
Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
The Journal of pharmacology and experimental therapeutics 1997;283(2):434-42.
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1997: Guengerich F P; Parikh A; Johnson E F; Richardson T H; von Wachenfeldt C; Cosme J; Jung F; Strassburg C P; Manns M P; Tukey R H; Pritchard M; Fournel-Gigleux S; Burchell B
Heterologous expression of human drug-metabolizing enzymes.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1234-41.
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1997: Guengerich F P; Parikh A
Expression of drug-metabolizing enzymes.
Current opinion in biotechnology 1997;8(5):623-8.
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1997: Kim M S; Guengerich F P
Synthesis of oligonucleotides containing the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione at a single site.
Chemical research in toxicology 1997;10(10):1133-43.
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1997: Gillam E M; Wunsch R M; Ueng Y F; Shimada T; Reilly P E; Kamataki T; Guengerich F P
Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase.
Archives of biochemistry and biophysics 1997;346(1):81-90.
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1997: Parikh A; Gillam E M; Guengerich F P
Drug metabolism by Escherichia coli expressing human cytochromes P450.
Nature biotechnology 1997;15(8):784-8.
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1997: Johnson W W; Yamazaki H; Shimada T; Ueng Y F; Guengerich F P
Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.
Chemical research in toxicology 1997;10(6):672-6.
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1997: Yamazaki H; Gillam E M; Dong M S; Johnson W W; Guengerich F P; Shimada T
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
Archives of biochemistry and biophysics 1997;342(2):329-37.
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1997: Johnson W W; Guengerich F P
Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6121-5.
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1997: Furge L L; Guengerich F P
Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics.
Biochemistry 1997;36(21):6475-87.
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1997: Langouët S; Müller M; Guengerich F P
Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcriptase, and rat polymerase beta.
Biochemistry 1997;36(20):6069-79.
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1997: Anderson K E; Hammons G J; Kadlubar F F; Potter J D; Kaderlik K R; Ilett K F; Minchin R F; Teitel C H; Chou H C; Martin M V; Guengerich F P; Barone G W; Lang N P; Peterson L A
Metabolic activation of aromatic amines by human pancreas.
Carcinogenesis 1997;18(5):1085-92.
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1997: Shimada T; Gillam E M; Sutter T R; Strickland P T; Guengerich F P; Yamazaki H
Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(5):617-22.
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1997: Inoue K; Yamazaki H; Imiya K; Akasaka S; Guengerich F P; Shimada T
Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations.
Pharmacogenetics 1997;7(2):103-13.
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1997: Parikh A; Guengerich F P
Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:rat NADPH-cytochrome P450 reductase fusion protein.
Protein expression and purification 1997;9(3):346-54.
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1997: Johnson W W; Ueng Y F; Widersten M; Mannervik B; Hayes J D; Sherratt P J; Ketterer B; Guengerich F P
Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters.
Biochemistry 1997;36(11):3056-60.
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1997: Müller M; Belas F J; Blair I A; Guengerich F P
Analysis of 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in DNA treated with 2-chlorooxirane by high performance liquid chromatography/electrospray mass spectrometry and comparison of amounts to other DNA adducts.
Chemical research in toxicology 1997;10(2):242-7.
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1997: Yamazaki H; Inoue K; Turvy C G; Guengerich F P; Shimada T
Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(2):168-74.
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1997: Foroozesh M; Primrose G; Guo Z; Bell L C; Alworth W L; Guengerich F P
Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes.
Chemical research in toxicology 1997;10(1):91-102.
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1997: Guengerich F P; Vaz A D; Raner G N; Pernecky S J; Coon M J
Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes.
Molecular pharmacology 1997;51(1):147-51.
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1997: Ueng Y F; Kuwabara T; Chun Y J; Guengerich F P
Cooperativity in oxidations catalyzed by cytochrome P450 3A4.
Biochemistry 1997;36(2):370-81.
-
1997: Tateishi T; Soucek P; Caraco Y; Guengerich F P; Wood A J
Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.
Biochemical pharmacology 1997;53(1):111-6.
-
1997: Guengerich F P
Role of cytochrome P450 enzymes in drug-drug interactions.
Advances in pharmacology (San Diego, Calif.) 1997;43():7-35.
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1997: Guengerich F P; Kim M S; Müller M; Lowe L G
Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():49-63.
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1996: Yamazaki H; Johnson W W; Ueng Y F; Shimada T; Guengerich F P
Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
The Journal of biological chemistry 1996;271(44):27438-44.
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1996: Guengerich F P; Yun C H; Macdonald T L
Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates.
The Journal of biological chemistry 1996;271(44):27321-9.
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1996: Müller M; Hutchinson L K; Guengerich F P
Addition of deoxyribose to guanine and modified DNA based by Lactobacillus helveticus trans-N-deoxyribosylase.
Chemical research in toxicology 1996;9(7):1140-4.
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1996: Kim R B; Yamazaki H; Chiba K; O'Shea D; Mimura M; Guengerich F P; Ishizaki T; Shimada T; Wilkinson G R
In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.
The Journal of pharmacology and experimental therapeutics 1996;279(1):4-11.
-
1996: Guengerich F P; Gillam E M; Shimada T
New applications of bacterial systems to problems in toxicology.
Critical reviews in toxicology 1996;26(5):551-83.
-
1996: Dong M S; Bell L C; Guo Z; Phillips D R; Blair I A; Guengerich F P
Identification of retained N-formylmethionine in bacterial recombinant mammalian cytochrome P450 proteins with the N-terminal sequence MALLLAVFL...: roles of residues 3-5 in retention and membrane topology.
Biochemistry 1996;35(31):10031-40.
-
1996: Caraco Y; Tateishi T; Guengerich F P; Wood A J
Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):761-4.
-
1996: Lowe L G; Guengerich F P
Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-.
Biochemistry 1996;35(30):9840-9.
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1996: Yamazaki H; Nakano M; Gillam E M; Bell L C; Guengerich F P; Shimada T
Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes.
Biochemical pharmacology 1996;52(2):301-9.
-
1996: Shimada T; Hayes C L; Yamazaki H; Amin S; Hecht S S; Guengerich F P; Sutter T R
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
Cancer research 1996;56(13):2979-84.
-
1996: Chun Y J; Shimada T; Guengerich F P
Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.
Archives of biochemistry and biophysics 1996;330(1):48-58.
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1996: Guengerich F P; Johnson W W; Ueng Y F; Yamazaki H; Shimada T
Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer.
Environmental health perspectives 1996;104 Suppl 3():557-62.
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1996: Shimada T; Yamazaki H; Mimura M; Wakamiya N; Ueng Y F; Guengerich F P; Inui Y
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(5):515-22.
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1996: Nakhgevany R; Bonsu O; Barber J; Mabrouk P A; Ueng Y F; Bell L C; Guengerich F P
Preparation, purification, and spectrophotometric characterization of cytochrome P450 1A2 conjugated with polyethylene glycol monomethyl ether.
Biochemical and biophysical research communications 1996;222(2):406-9.
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1996: Shimada T; Yamazaki H; Guengerich F P
Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(4):395-403.
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1996: Dong M S; Yamazaki H; Guo Z; Guengerich F P
Recombinant human cytochrome P450 1A2 and an N-terminal-truncated form: construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase.
Archives of biochemistry and biophysics 1996;327(1):11-9.
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1996: Oda Y; Yamazaki H; Thier R; Ketterer B; Guengerich F P; Shimada T
A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system.
Carcinogenesis 1996;17(2):297-302.
-
1996: Anzenbacher P; Niwa T; Tolbert L M; Sirimanne S R; Guengerich F P
Oxidation of 9-alkylanthracenes by cytochrome P450 2B1, horseradish peroxidase, and iron tetraphenylporphine/iodosylbenzene systems: anaerobic and aerobic mechanisms.
Biochemistry 1996;35(8):2512-20.
-
1996: Yamazaki H; Inoue K; Mimura M; Oda Y; Guengerich F P; Shimada T
7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.
Biochemical pharmacology 1996;51(3):313-9.
-
1996: Shimada T; Yamazaki H; Oda Y; Hiratsuka A; Watabe T; Guengerich F P
Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004.
Chemical research in toxicology 1996;9(1):333-40.
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1996: Tateishi T; Krivoruk Y; Ueng Y F; Wood A J; Guengerich F P; Wood M
Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.
Anesthesia and analgesia 1996;82(1):167-72.
-
1996: Thier R; Pemble S E; Kramer H; Taylor J B; Guengerich F P; Ketterer B
Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium.
Carcinogenesis 1996;17(1):163-6.
-
1996: Yamazaki H; Nakano M; Imai Y; Ueng Y F; Guengerich F P; Shimada T
Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes.
Archives of biochemistry and biophysics 1996;325(2):174-82.
-
1996: Chang M S; Boeglin W E; Guengerich F P; Brash A R
Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products.
Biochemistry 1996;35(2):464-71.
-
1996: Lang C C; Brown R M; Kinirons M T; Deathridge M A; Guengerich F P; Kelleher D; O'Briain D S; Ghishan F K; Wood A J
Decreased intestinal CYP3A in celiac disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism.
Clinical pharmacology and therapeutics 1996;59(1):41-6.
-
1996: Müller M; Belas F; Ueno H; Guengerich F P
Development of a mass spectrometric assay for 5,6,7,9-tetrahydro-7-hydroxy-9-oximidazo[1,2-alpha] purine in DNA modified by 2-chloro-oxirane.
Advances in experimental medicine and biology 1996;387():31-6.
-
1996: Guengerich F P; Ueng Y F; Kim B R; Langouet S; Coles B; Iyer R S; Thier R; Harris T M; Shimada T; Yamazaki H; Ketterer B; Guillouzo A
Activation of toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1.
Advances in experimental medicine and biology 1996;387():7-15.
-
1996: Guengerich F P; Martin M V; Guo Z; Chun Y J
Purification of functional recombinant P450s from bacteria.
Methods in enzymology 1996;272():35-44.
-
1995: Soucek P; Martin M V; Ueng Y F; Guengerich F P
Identification of a common cytochrome P450 epitope near the conserved heme-binding petide with antibodies raised against recombinant cytochrome P450 family 2 proteins.
Biochemistry 1995;34(49):16013-21.
-
1995: Tateishi T; Wood A J; Guengerich F P; Wood M
Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol.
Biochemical pharmacology 1995;50(11):1921-4.
-
1995: Yamazaki H; Inui Y; Wrighton S A; Guengerich F P; Shimada T
Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes.
Carcinogenesis 1995;16(9):2167-70.
-
1995: Yamazaki H; Ueng Y F; Shimada T; Guengerich F P
Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.
Biochemistry 1995;34(26):8380-9.
-
1995: Guengerich F P; Okazaki O; Seto Y; Macdonald T L
Radical cation intermediates in N-dealkylation reactions.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(7):689-709.
-
1995: Guengerich F P
Cytochrome P450 proteins and potential utilization in biodegradation.
Environmental health perspectives 1995;103 Suppl 5():25-8.
-
1995: Gillam E M; Guo Z; Martin M V; Jenkins C M; Guengerich F P
Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization.
Archives of biochemistry and biophysics 1995;319(2):540-50.
-
1995: Thier R; Müller M; Taylor J B; Pemble S E; Ketterer B; Guengerich F P
Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase.
Chemical research in toxicology 1995;8(3):465-72.
-
1995: Gillam E M; Guo Z; Ueng Y F; Yamazaki H; Cock I; Reilly P E; Hooper W D; Guengerich F P
Expression of cytochrome P450 3A5 in Escherichia coli: effects of 5' modification, purification, spectral characterization, reconstitution conditions, and catalytic activities.
Archives of biochemistry and biophysics 1995;317(2):374-84.
-
1995: Ueng Y F; Shimada T; Yamazaki H; Guengerich F P
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes.
Chemical research in toxicology 1995;8(2):218-25.
-
1995: Yamazaki H; Guo Z; Guengerich F P
Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(3):438-40.
-
1995: Bauer E; Guo Z; Ueng Y F; Bell L C; Zeldin D; Guengerich F P
Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes.
Chemical research in toxicology 1995;8(1):136-42.
-
1995: Guengerich F P; Humphreys W G; Yun C H; Hammons G J; Kadlubar F F; Seto Y; Okazaki O; Martin M V
Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues.
Princess Takamatsu symposia 1995;23():78-84.
-
1995: Guengerich F P; Bell L C; Okazaki O
Interpretations of cytochrome P450 mechanisms from kinetic studies.
Biochimie 1995;77(7-8):573-80.
-
1995: Guengerich F P; Thier R; Persmark M; Taylor J B; Pemble S E; Ketterer B
Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk.
Pharmacogenetics 1995;5 Spec No():S103-7.
-
1994: Shimada T; Gillam E M; Sandhu P; Guo Z; Tukey R H; Guengerich F P
Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays.
Carcinogenesis 1994;15(11):2523-9.
-
1994: Guengerich F P; Shimada T; Yun C H; Yamazaki H; Raney K D; Thier R; Coles B; Harris T M
Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes.
Environmental health perspectives 1994;102 Suppl 9():49-53.
-
1994: Yamazaki H; Guo Z; Persmark M; Mimura M; Inoue K; Guengerich F P; Shimada T
Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
Molecular pharmacology 1994;46(3):568-77.
-
1994: Inoue K; Inazawa J; Suzuki Y; Shimada T; Yamazaki H; Guengerich F P; Abe T
Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1.
The Japanese journal of human genetics 1994;39(3):337-43.
-
1994: Guo Z; Gillam E M; Ohmori S; Tukey R H; Guengerich F P
Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties.
Archives of biochemistry and biophysics 1994;312(2):436-46.
-
1994: Persmark M; Guengerich F P
Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements.
Biochemistry 1994;33(29):8662-72.
-
1994: Shimada T; Yamazaki H; Mimura M; Inui Y; Guengerich F P
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
The Journal of pharmacology and experimental therapeutics 1994;270(1):414-23.
-
1994: Gillam E M; Guo Z; Guengerich F P
Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.
Archives of biochemistry and biophysics 1994;312(1):59-66.
-
1994: Guengerich F P; Persmark M
Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde.
Chemical research in toxicology 1994;7(2):205-8.
-
1994: Yamazaki H; Mimura M; Oda Y; Gonzalez F J; el-Bayoumy K; Chae Y H; Guengerich F P; Shimada T
Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450.
Carcinogenesis 1994;15(3):465-70.
-
1994: Sandhu P; Guo Z; Baba T; Martin M V; Tukey R H; Guengerich F P
Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.
Archives of biochemistry and biophysics 1994;309(1):168-77.
-
1994: Guengerich F P
Mechanisms of formation of DNA adducts from ethylene dihalides, vinyl halides, and arylamines.
Drug metabolism reviews 1994;26(1-2):47-66.
-
1994: Guengerich F P
Metabolism and genotoxicity of dihaloalkanes.
Advances in pharmacology (San Diego, Calif.) 1994;27():211-36.
-
1994: Guengerich F P; Min K S; Persmark M; Kim M S; Humphreys W G; Cmarik J M; Thier R
Dihaloalkanes and polyhaloalkenes.
IARC scientific publications 1994;(125):57-72.
-
1994: Persmark M; Humphreys W G; Okazaki O; Raney V M; Guengerich F P
Mechanisms of formation of 1,N6-ethenoadenine, 3,N4-ethenocytosine, 1,N2-ethenoguanine and N2,3-ethenoguanine DNA adducts from substituted oxiranes.
IARC scientific publications 1994;(125):437-41.
-
1993: Sandhu P; Baba T; Guengerich F P
Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity.
Archives of biochemistry and biophysics 1993;306(2):443-50.
-
1993: Kim M S; Guengerich F P
Interactions of N7-guanyl methyl- and thioether-substituted d(CATGCCT) derivatives with d(AGGNATG).
Chemical research in toxicology 1993;6(6):900-5.
-
1993: Mimura M; Baba T; Yamazaki H; Ohmori S; Inui Y; Gonzalez F J; Guengerich F P; Shimada T
Characterization of cytochrome P-450 2B6 in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1048-56.
-
1993: Guengerich F P; Gillam E M; Ohmori S; Sandhu P; Brian W R; Sari M A; Iwasaki M
Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity.
Toxicology 1993;82(1-3):21-37.
-
1993: Thier R; Taylor J B; Pemble S E; Humphreys W G; Persmark M; Ketterer B; Guengerich F P
Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8576-80.
-
1993: Guengerich F P; Persmark M; Humphreys W G
Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine.
Chemical research in toxicology 1993;6(5):635-48.
-
1993: Seto Y; Guengerich F P
Liquid chromatographic determination of para-substituted N,N-dialkylaniline N-oxides.
Journal of chromatography 1993;619(1):71-7.
-
1993: Gillam E M; Baba T; Kim B R; Ohmori S; Guengerich F P
Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.
Archives of biochemistry and biophysics 1993;305(1):123-31.
-
1993: Yamazaki H; Mimura M; Oda Y; Inui Y; Shiraga T; Iwasaki K; Guengerich F P; Shimada T
Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes.
Carcinogenesis 1993;14(7):1271-8.
-
1993: Karara A; Makita K; Jacobson H R; Falck J R; Guengerich F P; DuBois R N; Capdevila J H
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase.
The Journal of biological chemistry 1993;268(18):13565-70.
-
1993: Seto Y; Guengerich F P
Partitioning between N-dealkylation and N-oxygenation in the oxidation of N,N-dialkylarylamines catalyzed by cytochrome P450 2B1.
The Journal of biological chemistry 1993;268(14):9986-97.
-
1993: Yun C H; Okerholm R A; Guengerich F P
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(3):403-9.
-
1993: Okazaki O; Persmark M; Guengerich F P
N-nitroso-N-methylvinylamine: reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule.
Chemical research in toxicology 1993;6(2):168-73.
-
1993: Okazaki O; Guengerich F P
Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase. Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases.
The Journal of biological chemistry 1993;268(3):1546-52.
-
1993: Guengerich F P
The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):1-6.
-
1993: Meyer D J; Coles B; Harris J; Gilmore K S; Raney K; Harris T M; Guengerich F P; Kensler T W; Ketterer B
Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties.
Basic life sciences 1993;61():171-9.
-
1992: Shimada T; Yamazaki H; Mimura M; Guengerich F P
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens.
Mutation research 1992;284(2):233-41.
-
1992: Guengerich F P; Shimada T; Raney K D; Yun C H; Meyer D J; Ketterer B; Harris T M; Groopman J D; Kadlubar F F
Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
Environmental health perspectives 1992;98():75-80.
-
1992: Yun C H; Hammons G J; Jones G; Martin M V; Hopkins N E; Alworth W L; Guengerich F P
Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl.
Biochemistry 1992;31(43):10556-63.
-
1992: Yamazaki H; Inui Y; Yun C H; Guengerich F P; Shimada T
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes.
Carcinogenesis 1992;13(10):1789-94.
-
1992: Capdevila J H; Wei S; Yan J; Karara A; Jacobson H R; Falck J R; Guengerich F P; DuBois R N
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.
The Journal of biological chemistry 1992;267(30):21720-6.
-
1992: Yun C H; Wood M; Wood A J; Guengerich F P
Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance.
Anesthesiology 1992;77(3):467-74.
-
1992: Humphreys W G; Kadlubar F F; Guengerich F P
Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8278-82.
-
1992: Raney K D; Meyer D J; Ketterer B; Harris T M; Guengerich F P
Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases.
Chemical research in toxicology 1992;5(4):470-8.
-
1992: Yamazaki H; Oda Y; Funae Y; Imaoka S; Inui Y; Guengerich F P; Shimada T
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
Carcinogenesis 1992;13(6):979-85.
-
1992: Inoue K; Inazawa J; Nakagawa H; Shimada T; Yamazaki H; Guengerich F P; Abe T
Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization.
The Japanese journal of human genetics 1992;37(2):133-8.
-
1992: Fleming C M; Branch R A; Wilkinson G R; Guengerich F P
Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.
Molecular pharmacology 1992;41(5):975-80.
-
1992: Shimada T; Yun C H; Yamazaki H; Gautier J C; Beaune P H; Guengerich F P
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.
Molecular pharmacology 1992;41(5):856-64.
-
1992: Raney K D; Coles B; Guengerich F P; Harris T M
The endo-8,9-epoxide of aflatoxin B1: a new metabolite.
Chemical research in toxicology 1992;5(3):333-5.
-
1992: Cmarik J L; Humphreys W G; Bruner K L; Lloyd R S; Tibbetts C; Guengerich F P
Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide.
The Journal of biological chemistry 1992;267(10):6672-9.
-
1992: Yun C H; Shimada T; Guengerich F P
Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.
Cancer research 1992;52(7):1868-74.
-
1992: Raney K D; Shimada T; Kim D H; Groopman J D; Harris T M; Guengerich F P
Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1.
Chemical research in toxicology 1992;5(2):202-10.
-
1992: Yun C H; Shimada T; Guengerich F P
Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline).
Carcinogenesis 1992;13(2):217-22.
-
1992: Guengerich F P
Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]
Chemical research in toxicology 1992;5(1):2-5.
-
1992: Guengerich F P
Characterization of human cytochrome P450 enzymes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):745-8.
-
1992: Guengerich F P
Cytochrome P450: advances and prospects.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):667-8.
-
1992: Guengerich F P; Raney K D; Kim D H; Shimada T; Meyer D J; Ketterer B; Harris T M
Oxidation and conjugation of aflatoxins by humans and experimental animals.
Progress in clinical and biological research 1992;374():157-65.
-
1992: Guengerich F P
Human cytochrome P-450 enzymes.
Life sciences 1992;50(20):1471-8.
-
1992: Guengerich F P
Metabolic activation of carcinogens.
Pharmacology & therapeutics 1992;54(1):17-61.
-
1991: Yun C H; Shimada T; Guengerich F P
Purification and characterization of human liver microsomal cytochrome P-450 2A6.
Molecular pharmacology 1991;40(5):679-85.
-
1991: Humphreys W G; Guengerich F P
Structure of formamidopyrimidine adducts as determined by NMR using specifically 15N-labeled guanosine.
Chemical research in toxicology 1991;4(6):632-6.
-
1991: Shimada T; Guengerich F P
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.
Cancer research 1991;51(19):5284-91.
-
1991: Oida T; Humphreys W G; Guengerich F P
Preparation and characterization of oligonucleotides containing S-[2-(N7-guanyl)ethyl]glutathione.
Biochemistry 1991;30(43):10513-22.
-
1991: Humphreys W G; Kim D H; Guengerich F P
Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane.
Chemical research in toxicology 1991;4(4):445-53.
-
1991: Guengerich F P; Kim D H
Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine.
Chemical research in toxicology 1991;4(4):413-21.
-
1991: Guengerich F P; Shimada T
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes.
Chemical research in toxicology 1991;4(4):391-407.
-
1991: Srivastava P K; Yun C H; Beaune P H; Ged C; Guengerich F P
Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
Molecular pharmacology 1991;40(1):69-79.
-
1991: Guengerich F P; Brian W R; Iwasaki M; Sari M A; Bäärnhielm C; Berntsson P
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.
Journal of medicinal chemistry 1991;34(6):1838-44.
-
1991: Guengerich F P
Reactions and significance of cytochrome P-450 enzymes.
The Journal of biological chemistry 1991;266(16):10019-22.
-
1991: Guengerich F P; Turvy C G
Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.
The Journal of pharmacology and experimental therapeutics 1991;256(3):1189-94.
-
1991: Guengerich F P; Kim D H; Iwasaki M
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
Chemical research in toxicology 1991;4(2):168-79.
-
1991: Ketterer B; Meyer D J; Lalor E; Johnson P; Guengerich F P; Distlerath L M; Reilly P E; Kadlubar F F; Flammang T J; Yamazoe Y
A comparison of levels of glutathione transferases, cytochromes P450 and acetyltransferases in human livers.
Biochemical pharmacology 1991;41(4):635-8.
-
1991: Yamazaki H; Degawa M; Funae Y; Imaoka S; Inui Y; Guengerich F P; Shimada T
Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes.
Carcinogenesis 1991;12(1):133-9.
-
1991: Guengerich F P; Shimada T; Bondon A; Macdonald T L
Cytochrome P-450 oxidations and the generation of biologically reactive intermediates.
Advances in experimental medicine and biology 1991;283():1-11.
-
1991: Oida T; Humphreys W G; Guengerich F P
Effects of adduct formation derived from ethylene dibromide on DNA conformation.
Nucleic acids symposium series 1991;(25):135-6.
-
1991: Guengerich F P; Brian W R; Sari M A; Ross J T
Expression of mammalian cytochrome P450 enzymes using yeast-based vectors.
Methods in enzymology 1991;206():130-45.
-
1990: Brian W R; Sari M A; Iwasaki M; Shimada T; Kaminsky L S; Guengerich F P
Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.
Biochemistry 1990;29(51):11280-92.
-
1990: Guengerich F P; Kim D H
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.
Carcinogenesis 1990;11(12):2275-9.
-
1990: Guengerich F P
Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs.
American journal of obstetrics and gynecology 1990;163(6 Pt 2):2159-63.
-
1990: Humphreys W G; Kim D H; Cmarik J L; Shimada T; Guengerich F P
Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives.
Biochemistry 1990;29(45):10342-50.
-
1990: Kim D H; Humphreys W G; Guengerich F P
Characterization of S-[2-(N1-adenyl)ethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane.
Chemical research in toxicology 1990;3(6):587-94.
-
1990: Wrighton S A; Brian W R; Sari M A; Iwasaki M; Guengerich F P; Raucy J L; Molowa D T; Vandenbranden M
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).
Molecular pharmacology 1990;38(2):207-13.
-
1990: Guengerich F P
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene.
Chemical research in toxicology 1990;3(4):363-71.
-
1990: Cmarik J L; Inskeep P B; Meredith M J; Meyer D J; Ketterer B; Guengerich F P
Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes.
Cancer research 1990;50(9):2747-52.
-
1990: Guengerich F P; MacDonald T L
Mechanisms of cytochrome P-450 catalysis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(8):2453-9.
-
1990: Shimada T; Guengerich F P
Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.
Cancer research 1990;50(7):2036-43.
-
1990: Kim D H; Guengerich F P
Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation.
Carcinogenesis 1990;11(3):419-24.
-
1990: Shimada T; Yamazaki H; Shimura H; Tanaka R; Guengerich F P
Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes.
Carcinogenesis 1990;11(1):103-10.
-
1990: Guengerich F P
Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism.
Chemical research in toxicology 1990;3(1):21-6.
-
1990: Guengerich F P
Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue.
Pharmacology & therapeutics 1990;45(3):299-307.
-
1990: Guengerich F P; Shimada T; Iwasaki M; Butler M A; Kadlubar F F
Activation of carcinogens by human liver cytochromes P-450.
Basic life sciences 1990;53():381-96.
-
1990: Guengerich F P
Metabolism of 17 alpha-ethynylestradiol in humans.
Life sciences 1990;47(22):1981-8.
-
1990: Guengerich F P; Shimada T; Iwasaki M; Martin M V
Activation of mutagens by human cytochrome P-450 enzymes.
Progress in clinical and biological research 1990;340B():87-96.
-
1990: Guengerich F P; Humphreys W G; Kim D H; Oida T; Cmarik J L
DNA-glutathione adducts derived from vic-dihaloalkanes: mechanisms of mutagenesis.
Princess Takamatsu symposia 1990;21():101-7.
-
1989: Kim D H; Guengerich F P
Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetylcysteine in urine following administration of ethylene dibromide to rats.
Cancer research 1989;49(21):5843-7.
-
1989: Hammons G J; Alworth W L; Hopkins N E; Guengerich F P; Kadlubar F F
2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine.
Chemical research in toxicology 1989;2(6):367-74.
-
1989: Shimada T; Martin M V; Pruess-Schwartz D; Marnett L J; Guengerich F P
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
Cancer research 1989;49(22):6304-12.
-
1989: Guengerich F P
Oxidation of halogenated compounds by cytochrome P-450, peroxidases, and model metalloporphyrins.
The Journal of biological chemistry 1989;264(29):17098-205.
-
1989: Brian W R; Srivastava P K; Umbenhauer D R; Lloyd R S; Guengerich F P
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
Biochemistry 1989;28(12):4993-9.
-
1989: Shimada T; Iwasaki M; Martin M V; Guengerich F P
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.
Cancer research 1989;49(12):3218-28.
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1989: Baertschi S W; Raney K D; Shimada T; Harris T M; Guengerich F P
Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses.
Chemical research in toxicology 1989;2(2):114-2.
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1989: Bondon A; Macdonald T L; Harris T M; Guengerich F P
Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation.
The Journal of biological chemistry 1989;264(4):1988-97.
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1989: Shimada T; Guengerich F P
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):462-5.
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1989: Bork R W; Muto T; Beaune P H; Srivastava P K; Lloyd R S; Guengerich F P
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
The Journal of biological chemistry 1989;264(2):910-9.
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1989: Brian W R; Ged C; Bellew T M; Srivastava P K; Bork R W; Umbenhauer D R; Lloyd R S; Guengerich F P
Human liver mephenytoin 4'-hydroxylase cytochrome P-450 proteins and genes.
Drug metabolism reviews 1989;20(2-4):449-65.
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1989: Wilkinson G R; Guengerich F P; Branch R A
Genetic polymorphism of S-mephenytoin hydroxylation.
Pharmacology & therapeutics 1989;43(1):53-76.
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1988: Ged C; Umbenhauer D R; Bellew T M; Bork R W; Srivastava P K; Shinriki N; Lloyd R S; Guengerich F P
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
Biochemistry 1988;27(18):6929-40.
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1988: Knodell R G; Dubey R K; Wilkinson G R; Guengerich F P
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
The Journal of pharmacology and experimental therapeutics 1988;245(3):845-9.
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1988: Guengerich F P; Peterson L A; Böcker R H
Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.
The Journal of biological chemistry 1988;263(17):8176-83.
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1988: Guengerich F P; Böcker R H
Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines.
The Journal of biological chemistry 1988;263(17):8168-75.
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1988: Guengerich F P
Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.
Cancer research 1988;48(11):2946-54.
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1988: Guengerich F P
Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.
Molecular pharmacology 1988;33(5):500-8.
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1988: Gozakara E M; Guengerich F P; Gelboin H V
Cell-catalyzed binding of 3H-(-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to cellular and exogenous DNA and the role of purified human liver epoxide hydrolase.
Pharmacology 1988;37(3):154-64.
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1987: Flammang T J; Yamazoe Y; Guengerich F P; Kadlubar F F
The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype.
Carcinogenesis 1987;8(12):1967-70.
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1987: Guengerich F P; Peterson L A; Cmarik J L; Koga N; Inskeep P B
Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts.
Environmental health perspectives 1987;76():15-8.
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1987: Guengerich F P; Churchill P F; Jung C Y; Fleischer S
Target inactivation analysis applied to determination of molecular weights of rat liver proteins in the purified state and in microsomal membranes.
Biochimica et biophysica acta 1987;915(2):246-53.
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1987: Guengerich F P; Beaune P H; Umbenhauer D R; Churchill P F; Bork R W; Dannan G A; Knodell R G; Lloyd R S; Martin M V
Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans.
Biochemical Society transactions 1987;15(4):576-8.
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1987: Guengerich F P; Umbenhauer D R; Churchill P F; Beaune P H; Böcker R; Knodell R G; Martin M V; Lloyd R S
Polymorphism of human cytochrome P-450.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(3):311-6.
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1987: Wolff T; Distlerath L M; Worthington M T; Guengerich F P
Human liver debrisoquine 4-hydroxylase: test for specificity toward various monooxygenase substrates and model of the active site.
Archives of toxicology 1987;60(1-3):89-90.
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1986: Beaune P H; Umbenhauer D R; Bork R W; Lloyd R S; Guengerich F P
Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8064-8.
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1986: Inskeep P B; Koga N; Cmarik J L; Guengerich F P
Covalent binding of 1,2-dihaloalkanes to DNA and stability of the major DNA adduct, S-[2-(N7-guanyl)ethyl]glutathione.
Cancer research 1986;46(6):2839-44.
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1986: Guengerich F P; Distlerath L M; Reilly P E; Wolff T; Shimada T; Umbenhauer D R; Martin M V
Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation.
Xenobiotica; the fate of foreign compounds in biological systems 1986;16(5):367-78.
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1986: Guengerich F P; Shimada T; Umbenhauer D R; Martin M V; Misono K S; Distlerath L M; Reilly P E; Wolff T
Structure and function of cytochrome P-450.
Advances in experimental medicine and biology 1986;197():83-94.
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1985: Distlerath L M; Reilly P E; Martin M V; Davis G G; Wilkinson G R; Guengerich F P
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.
The Journal of biological chemistry 1985;260(15):9057-67.
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1985: Wolff T; Distlerath L M; Worthington M T; Groopman J D; Hammons G J; Kadlubar F F; Prough R A; Martin M V; Guengerich F P
Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.
Cancer research 1985;45(5):2116-22.
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