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A Guglietta

Research Profile

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Chemicals & Drugs

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Publications

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Yuntao Song; David T Connor; AD Sercel; Roderick J Sorenson; R Doubleday; Paul C Unangst; Bruce D Roth; V G Beylin; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Yuntao Song; David T Connor; R Doubleday; Roderick J Sorenson; AD Sercel; Paul C Unangst; Bruce D Roth; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Charles Lesch; E R Kraus; B Sanchez; RB Gilbertsen; A Guglietta
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.

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All Publications

1999: Yuntao Song; David T Connor; AD Sercel; Roderick J Sorenson; R Doubleday; Paul C Unangst; Bruce D Roth; V G Beylin; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Journal of medicinal chemistry 1999;42(7):1161-9.
1999: Yuntao Song; David T Connor; R Doubleday; Roderick J Sorenson; AD Sercel; Paul C Unangst; Bruce D Roth; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Journal of medicinal chemistry 1999;42(7):1151-60.
1999: Charles Lesch; E R Kraus; B Sanchez; RB Gilbertsen; A Guglietta
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.
Methods and findings in experimental and clinical pharmacology 1999;21(2):99-104.
1998: Charles Lesch; RB Gilbertsen; Yuntao Song; Richard D Dyer; DJ Schrier; E R Kraus; B Sanchez; A Guglietta
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
The Journal of pharmacology and experimental therapeutics 1998;287(1):301-6.
1997: VM Baragi; Luping Qiu; Z Gunja-Smith; J Frederick Woessner; Charles Lesch; A Guglietta
Role of metalloproteinases in the development and healing of acetic acid-induced gastric ulcer in rats.
Scandinavian journal of gastroenterology 1997;32(5):419-26.
1996: Nywana Sizemore; R C Dudeck; C M Barksdale; G D Nordblom; W Thomas Mueller; Patrick McConnell; DS Wright; A Guglietta; B S Kuo
Development and validation of two solid-phase enzyme immunoassays (ELISA) for quantitation of human epidermal growth factors (hEGFs).
Pharmaceutical research 1996;13(7):1088-94.
1996: M Romano; Charles Lesch; Katherine S Meise; M Veljaca; B Sanchez; E R Kraus; C R Boland; A Guglietta; Robert J Coffey
Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats.
Gastroenterology 1996;110(5):1448-55.
1995: A Guglietta; P B Sullivan
Clinical applications of epidermal growth factor.
European journal of gastroenterology & hepatology 1995;7(10):945-50.
1995: M Veljaca; Charles Lesch; R Pllana; B Sanchez; K Chan; A Guglietta
BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.
The Journal of pharmacology and experimental therapeutics 1995;272(1):417-22.
1994: A Guglietta; Charles Lesch; M Romano; R W McClure; Robert J Coffey
Effect of transforming growth factor-alpha on gastric acid secretion in rats and monkeys.
Digestive diseases and sciences 1994;39(1):177-82.
1993: A Guglietta; Charles Lesch
Effect of h-EGF and h-EGF 1-48 on histamine-stimulated gastric acid secretion in rats and monkeys.
Journal of physiology, Paris 1993;87(6):343-7.
1992: A Guglietta; T Hervada; R V Nardi; Charles Lesch
Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.
Scandinavian journal of gastroenterology 1992;27(8):673-6.
1990: A Guglietta; T Hervada; R V Nardi
Computer-based quantitative morphometric analysis of the dynamic characteristics of indomethacin and ethanol-induced gastric lesions in the rat.
Journal of pharmacological methods 1990;24(1):73-8.
1990: Lawrence H Lazarus; W E Wilson; A Guglietta; R de Castiglione
Dermorphin interaction with rat brain opioid receptors: involvement of hydrophobic sites in the binding domain.
Molecular pharmacology 1990;37(6):886-92.
1990: A Guglietta; T Hervada; R V Nardi
The use of a thymidine incorporation assay in the evaluation of the healing process following ethanol or indomethacin-induced gastric damage in rats.
Methods and findings in experimental and clinical pharmacology 1990;12(3):163-6.
1989: A Guglietta; B J Irons; Lawrence H Lazarus; R de Castiglione; Pietro Melchiorri
Dimeric dermorphin peptides: central administration suppresses gastric acid secretion through interaction with mu-type opioid receptor.
Methods and findings in experimental and clinical pharmacology 1989;11(11):663-70.
1989: A Guglietta; R V Nardi; Lawrence H Lazarus
Indomethacin (i.c.v.) reverses the inhibitory action of peptides on gastric secretion.
European journal of pharmacology 1989;170(1-2):87-90.
1989: Lawrence H Lazarus; W E Wilson; R de Castiglione; A Guglietta
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors.
The Journal of biological chemistry 1989;264(6):3047-50.
1989: Lawrence H Lazarus; A Guglietta; W E Wilson; B J Irons; R de Castiglione
Dimeric dermorphin analogues as mu-receptor probes on rat brain membranes. Correlation between central mu-receptor potency and suppression of gastric acid secretion.
The Journal of biological chemistry 1989;264(1):354-62.
1988: A Guglietta; B J Irons; Lawrence H Lazarus; S P Sivam
Effects and mechanism of action of lithium chloride on gastric acid secretion in rats.
Gastroenterology 1988;95(6):1454-9.
1988: A Guglietta; B J Irons; Lawrence H Lazarus
Effect of bombesin, dermorphin and salmon calcitonin on gastric acid secretion in rats.
Methods and findings in experimental and clinical pharmacology 1988;10(8):481-5.
1988: Lawrence H Lazarus; B J Irons; L M Grimes; W E Wilson; A Guglietta; H Yajima
Assessment of neuromedin B polyclonal antibodies as molecular probes in neural tissue.
Journal of neuroscience methods 1988;23(2):161-72.
1988: Lawrence H Lazarus; A Guglietta; W E Wilson; L M Grimes; B J Irons; H Yajima
Neuromedin B: physiological and pharmacological perturbations.
Annals of the New York Academy of Sciences 1988;547():404-14.
1987: A Guglietta; B J Irons; Lawrence H Lazarus; Pietro Melchiorri
Structure-activity relationship of dermorphin on gastric secretion.
Endocrinology 1987;120(5):2137-43.
1985: A Guglietta; C L Strunk; B J Irons; Lawrence H Lazarus
Central neuromodulation of gastric acid secretion by bombesin-like peptides.
Peptides 1985;6 Suppl 3():75-81.
1985: Lawrence H Lazarus; W E Wilson; Giovanni Gaudino; B J Irons; A Guglietta
Evolutionary relationship between nonmammalian and mammalian peptides.
Peptides 1985;6 Suppl 3():295-307.
1982: Pietro Melchiorri; G F Erspamer; Vittorio Erspamer; A Guglietta; R De Castiglione; F Faoro; G Perseo; S Piani; F Santangelo
Synthetic peptides related to the dermorphins. II. Synthesis and biological activities of new analogues.
Peptides 1982;3(5):745-8.
1981: R de Castiglione; F Faoro; G Perseo; S Piani; F Santangelo; Pietro Melchiorri; Giuliana Falconieri-Erspamer; Vittorio Erspamer; A Guglietta
Synthetic peptides related to the dermorphins. I. Synthesis and biological activities of the shorter homologues and of analogues of the heptapeptides.
Peptides 1981;2(3):265-9.