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Jih-Hwa Guh

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Prostatic Neoplasms

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Publications

TOP 3
Konstantin V Kudryavtsev; Andrei V Churakov; Jih-Hwa Guh
2-(1H-Imidazol-1-yl)-4-[3-(trifluoro-meth-yl)phen-yl]-1,3-thia-zole.
Chun-Liang Chen; Tsung-Chih Chen; Jih-Hwa Guh; Hsi-Hsien Hsieh; Fong-Chun Huang; Kuo-Feng Huang; Chia-Chung Lee; Jing-Jer Lin; Deh-Ming Chang; Hsu-Shan Huang
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
Chia-Chun Yu; Hsun-Shuo Chang; Yu-Jia Chang; Ih-Sheng Chen; Yunn-Fang Ho; Jui-Ling Hsu; Lih-Ching Hsu; Ping-Jung Wu; Jih-Hwa Guh
Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.

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2013: Konstantin V Kudryavtsev; Andrei V Churakov; Jih-Hwa Guh
2-(1H-Imidazol-1-yl)-4-[3-(trifluoro-meth-yl)phen-yl]-1,3-thia-zole.
Acta crystallographica. Section E, Structure reports online 2013;69(Pt 2):o238.
2013: Chun-Liang Chen; Tsung-Chih Chen; Jih-Hwa Guh; Hsi-Hsien Hsieh; Fong-Chun Huang; Kuo-Feng Huang; Chia-Chung Lee; Jing-Jer Lin; Deh-Ming Chang; Hsu-Shan Huang
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
European journal of medicinal chemistry 2013;60():29-41.
2013: Chia-Chun Yu; Hsun-Shuo Chang; Yu-Jia Chang; Ih-Sheng Chen; Yunn-Fang Ho; Jui-Ling Hsu; Lih-Ching Hsu; Ping-Jung Wu; Jih-Hwa Guh
Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.
The Prostate 2013;73(2):133-45.
2012: Chia-Chun Yu; Peini Chen; Po-Cheng Chiang; Mao-Tien Kuo; Pin-Hsuan Lu; Wu-Che Wen; Jih-Hwa Guh
Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.
The Journal of nutritional biochemistry 2012;23(8):900-7.
2012: Jui-Ling Hsu; Lih-Ching Hsu; Tsai-Kun Li; Ching-Shih Chen; Yunn-Fang Ho; Jih-Hwa Guh
Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.
Biochemical pharmacology 2012;84(1):59-67.
2012: Jui-Ling Hsu; Lih-Ching Hsu; Pui-Kei Leong; Pin-Hsuan Lu; Ching-Shih Chen; Yunn-Fang Ho; Jih-Hwa Guh
Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.
Cancer letters 2012;319(2):214-22.
2012: Yuan-Wei Liu; Ji-Shu Tsai; Won-Bo Wang; Chung-Hsiung Chen; Yuan-Bin Cheng; Jih-Hwa Guh; Tsong-Long Hwang; Chih-Chuang Liaw; Ya-Ching Shen
Bioactive diterpenes from Callicarpa longissima.
Journal of natural products 2012;75(4):689-93.
2012: Che-Jen Hsiao; George Hsiao; Shih-Hsin Hsiao; Tzong-Huei Lee; Yen-Ju Chan; Wei-Lin Chen; Jih-Hwa Guh; Chi-Li Chung
Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells.
Chemico-biological interactions 2012;197(1):23-30.
2012: Chun-Han Chen; Jih-Hwa Guh; Cho-Hwa Liao; Shiow-Lin Pan; Ya-Ling Chang; Che-Ming Teng
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines.
Cancer letters 2012;315(1):1-11.
2012: Chia-Chung Lee; Jing-Jer Lin; Pen-Yuan Lin; Kuo-Feng Huang; Chun-Liang Chen; Tsung-Chih Chen; Jih-Hwa Guh; Fong-Chun Huang; Hsu-Shan Huang
Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.
European journal of medicinal chemistry 2012;47(1):323-36.
2011: Yi-Cheng Chen; Jui-Ling Hsu; Pin-Hsuan Lu; Chia-Chun Yu; Jih-Hwa Guh
ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers.
Toxicology and applied pharmacology 2011;257(3):412-9.
2011: Pin-Hsuan Lu; Chia-Chun Yu; Yi-Cheng Chen; Po-Cheng Chiang; Yunn-Fang Ho; Fan-Lu Kung; Jih-Hwa Guh
Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer.
The Journal of urology 2011;186(6):2434-41.
2011: Kuen-Haur Lee; Charles L Shapiro; Dasheng Wang; Hsiao-Ching Yang; Jih-Hwa Guh; En-Chi Hsu; Samuel K Kulp; Ching-Shih Chen
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator.
The Journal of biological chemistry 2011;286(45):39247-58.
2011: Wei-Jan Huang; Chiao-I Kuo; Yun-Chieh Lin; Chen-Yui Yang; Ping Yang; Chia-Chun Yu; Shi-Wei Chao; Ching-Chow Chen; Jih-Hwa Guh; Chung-I Chang
Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.
European journal of medicinal chemistry 2011;46(9):4042-9.
2011: Chun-Hou Liao; Jih-Hwa Guh; Shih-Chieh Chueh; Hong-Jeng Yu
Anti-angiogenic effects and mechanism of prazosin.
The Prostate 2011;71(9):976-84.
2011: Jui-Ling Hsu; Shiow-Lin Pan; Yunn-Fang Ho; Tsong-Long Hwang; Fan-Lu Kung; Jih-Hwa Guh
Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.
The Journal of urology 2011;185(5):1967-74.
2011: Ting-Chun Kuo; Po-Cheng Chiang; Chia-Chun Yu; Kyoko Goto; Kenneth F Bastow; Kuo-Hsiung Lee; Jih-Hwa Guh
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.
Biochemical pharmacology 2011;81(9):1136-44.
2011: Ting-chun Kuo; Wei-jan Huang; Jih-Hwa Guh
WJ9708012 exerts anticancer activity through PKC-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells.
Acta pharmacologica Sinica 2011;32(1):89-98.
2010: Chieh-Yu Peng; Shiow-Lin Pan; Hui-Chen Pai; An-Chi Tsai; Jih-Hwa Guh; Ya-Ling Chang; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo.
Shock (Augusta, Ga.) 2010;34(6):580-5.
2010: Yu-Wei Sun; Wei-Jan Huang; Che-Jen Hsiao; Yi-Cheng Chen; Pin-Hsuan Lu; Jih-Hwa Guh
Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways.
The Prostate 2010;70(12):1295-306.
2010: Wei-Ling Chang; Chih-Shiang Chang; Po-Cheng Chiang; Yunn-Fang Ho; Ju-Fang Liu; Kai-Wei Chang; Jih-Hwa Guh
2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
British journal of pharmacology 2010;160(7):1677-89.
2010: Chiung-Hua Huang; Jih-Hwa Guh; Grace Shiahuy Chen; Pin-Hsuan Lu; Ji-Wang Chern
Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways.
Naunyn-Schmiedeberg's archives of pharmacology 2010;382(2):159-69.
2010: An-Chi Tsai; Shiow-Lin Pan; Cho-Hwa Liao; Jih-Hwa Guh; Shih-Wei Wang; Hui-Lung Sun; Yi-Nan Liu; Chien-Chih Chen; Chien-Chang Shen; Ya-Ling Chang; Che-Ming Teng
Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo.
Cancer letters 2010;292(2):163-70.
2010: Yi-Cheng Chen; Fan-Lu Kung; Ian-Lih Tsai; Tsung-Hsien Chou; Ih-Sheng Chen; Jih-Hwa Guh
Cryptocaryone, a natural dihydrochalcone, induces apoptosis in human androgen independent prostate cancer cells by death receptor clustering in lipid raft and nonraft compartments.
The Journal of urology 2010;183(6):2409-18.
2010: Jih-Hwa Guh; Wei-Ling Chang; Jian Yang; Su-Lin Lee; Shuo Wei; Dasheng Wang; Samuel K Kulp; Ching-Shih Chen
Development of novel adenosine monophosphate-activated protein kinase activators.
Journal of medicinal chemistry 2010;53(6):2552-61.
2010: Po-Cheng Chiang; Ssu-Chia Lin; Shiow-Lin Pan; Ching-Hua Kuo; I-Lin Tsai; Mao-Tien Kuo; Wu-Che Wen; Peini Chen; Jih-Hwa Guh
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.
Biochemical pharmacology 2010;79(2):162-71.
2010: Yi-Nan Liu; Shiow-Lin Pan; Chieh-Yu Peng; Der-Yi Huang; Jih-Hwa Guh; Chien-Chih Chen; Chien-Chang Shen; Che-Ming Teng
Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells.
Shock (Augusta, Ga.) 2010;33(1):70-5.
2009: Shih-Sheng Wang; Mohamed H Abd El-Razek; Yi-Cheng Chen; Ching-Te Chien; Jih-Hwa Guh; Yao-Haur Kuo; Ya-Ching Shen
abeo-taxane diterpenoids from the Taiwanese Yew Taxus sumatrana.
Chemistry & biodiversity 2009;6(12):2255-62.
2009: Jui-Ling Hsu; Po-Cheng Chiang; Jih-Hwa Guh
Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78.
Naunyn-Schmiedeberg's archives of pharmacology 2009;380(5):373-82.
2009: Yi-Nan Liu; Shiow-Lin Pan; Cho-Hwa Liao; Der-Yi Huang; Jih-Hwa Guh; Chieh-Yu Peng; Ya-Ling Chang; Che-Ming Teng
Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7.
Shock (Augusta, Ga.) 2009;32(3):263-9.
2008: Chieh-Yu Peng; Shiow-Lin Pan; Ying-Wen Huang; Jih-Hwa Guh; Ya-Ling Chang; Che-Ming Teng
Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(6):579-88.
2008: Che-Jen Hsiao; Yunn-Fang Ho; John T-A Hsu; Wei-Ling Chang; Yi-Cheng Chen; Ya-Ching Shen; Ping-Chiang Lyu; Jih-Hwa Guh
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(6):599-608.
2008: Tzu-Hsuan Chen; Shiow-Lin Pan; Jih-Hwa Guh; Chien-Chih Chen; Yao-Ting Huang; Hui-Chen Pai; Che-Ming Teng
Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(5):447-57.
2008: Shiow-Lin Pan; Kai Y Tao; Jih-Hwa Guh; Hui L Sun; Der Y Huang; Ya L Chang; Che-Ming Teng
The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion.
Shock (Augusta, Ga.) 2008;30(5):496-502.
2008: S Y Wu; Shiow-Lin Pan; T H Chen; C H Liao; D Y Huang; Jih-Hwa Guh; Y L Chang; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway.
British journal of pharmacology 2008;155(4):505-13.
2008: Yi-Nan Liu; Shiow-Lin Pan; Chieh-Yu Peng; Der-Yi Huang; Jih-Hwa Guh; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells.
Shock (Augusta, Ga.) 2008;30(3):274-9.
2008: Tzu-Hsuan Chen; Shiow-Lin Pan; Jih-Hwa Guh; Cho-Hwa Liao; Der-Yi Huang; Chien-Chih Chen; Che-Ming Teng
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4250-8.
2008: Po-Cheng Chiang; Jui-Ling Hsu; Ting-Chun Yeh; Shiow-Lin Pan; Jih-Hwa Guh
Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(2):167-77.
2008: Che-Jen Hsiao; Tsia-Kun Li; Ya-Ling Chan; Ling-Wei Hsin; Cho-Hwa Liao; Chien-Hua Lee; Ping-Chiang Lyu; Jih-Hwa Guh
WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.
Biochemical pharmacology 2008;75(4):847-56.
2008: Shih-Wei Wang; Shiow-Lin Pan; Yu-Chun Huang; Jih-Hwa Guh; Po-Cheng Chiang; Duen-Yi Huang; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Molecular cancer therapeutics 2008;7(2):350-60.
2008: Ling-Wei Hsin; Hui-Po Wang; Pi-Hung Kao; On Lee; Wan-Ru Chen; Hung-Wei Chen; Jih-Hwa Guh; Ya-Ling Chan; Chin-Ping His; Ming-Show Yang; Tsai-Kun Li; Chieh-Hua Lee
Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.
Bioorganic & medicinal chemistry 2008;16(2):1006-14.
2008: Ching-Yu Chen; Yuan-Bin Cheng; Shun-Ying Chen; Ching-Te Chien; Yao-Haur Kuo; Jih-Hwa Guh; Ashraf Taha Khalil; Ya-Ching Shen
New bioactive clerodane diterpenoids from the roots of Casearia membranacea.
Chemistry & biodiversity 2008;5(1):162-7.
2007: Shih-Wei Wang; Shiow-Lin Pan; Chieh-Yu Peng; Der-Yi Huang; An-Chi Tsai; Ya-Ling Chang; Jih-Hwa Guh; Sheng-Chu Kuo; Kuo-Hsiung Lee; Che-Ming Teng
CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.
Cancer letters 2007;257(1):87-96.
2007: Ssu-Chia Lin; Shih-Chieh Chueh; Che-Jen Hsiao; Tsia-Kun Li; Tzu-Hsuan Chen; Cho-Hwa Liao; Ping-Chiang Lyu; Jih-Hwa Guh
Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle.
Neoplasia (New York, N.Y.) 2007;9(10):830-9.
2007: Ying-Cheng Chen; Pin-Hsuan Lu; Shiow-Lin Pan; Che-Ming Teng; Sheng-Chu Kuo; Tsung-Ping Lin; Yunn-Fang Ho; Yu-Chun Huang; Jih-Hwa Guh
Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.
Biochemical pharmacology 2007;74(1):10-9.
2007: H-L Sun; Yi-Nan Liu; Yao-Ting Huang; Shiow-Lin Pan; D-Y Huang; Jih-Hwa Guh; Fang-Yu Lee; Sheng-Chu Kuo; Che-Ming Teng
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
Oncogene 2007;26(27):3941-51.
2007: Ting-Chun Yeh; Po-Cheng Chiang; Tsai-Kun Li; Jui-Ling Hsu; Chun-Jung Lin; Shih-Wei Wang; Chieh-Yu Peng; Jih-Hwa Guh
Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.
Biochemical pharmacology 2007;73(6):782-92.
2007: Pin-Hsuan Lu; Shih-Chieh Chueh; Fan-Lu Kung; Shiow-Lin Pan; Ya-Ching Shen; Jih-Hwa Guh
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway.
European journal of pharmacology 2007;556(1-3):45-54.
2006: Pin-Hsuan Lu; Fan-Lu Kung; Sheng-Chu Kuo; Shih-Chieh Chueh; Jih-Hwa Guh
Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery.
Naunyn-Schmiedeberg's archives of pharmacology 2006;374(3):223-33.
2006: Po-Cheng Chiang; Fan-Lu Kung; Dong-Ming Huang; Tsai-Kun Li; Jia-Rong Fan; Shiow-Lin Pan; Ya-Ching Shen; Jih-Hwa Guh
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells.
European journal of pharmacology 2006;542(1-3):22-30.
2006: Yao-Ting Huang; Dong-Ming Huang; Shih-Chieh Chueh; Che-Ming Teng; Jih-Hwa Guh
Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells.
Cancer letters 2006;231(2):270-8.
2006: Yi-Nan Liu; Shiow-Lin Pan; Chieh-Yu Peng; Jih-Hwa Guh; Dong-Ming Huang; Ya-Ling Chang; Chun-Hung Lin; Hui-Chen Pai; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9.
The Journal of pharmacology and experimental therapeutics 2006;316(1):35-41.
2005: Yao-Ting Huang; Shiow-Lin Pan; Jih-Hwa Guh; Ya-Ling Chang; Fang-Yu Lee; Sheng-Chu Kuo; Che-Ming Teng
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells.
Molecular cancer therapeutics 2005;4(10):1628-35.
2005: Po-Cheng Chiang; Chung-Liang Chien; Shiow-Lin Pan; Wen-Pin Chen; Che-Ming Teng; Ya-Ching Shen; Jih-Hwa Guh
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Journal of hepatology 2005;43(4):679-86.
2005: Shiow-Lin Pan; Jih-Hwa Guh; Chieh-Yu Peng; Shih-Wei Wang; Ya-Ling Chang; Fong-Chi Cheng; Jau-Hsiang Chang; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models.
The Journal of pharmacology and experimental therapeutics 2005;314(1):35-42.
2005: Shiow-Lin Pan; Jih-Hwa Guh; Chieh-Yu Peng; Ya-Ling Chang; Fong-Chi Cheng; Jau-Hsiang Chang; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models.
Thrombosis and haemostasis 2005;93(5):940-8.
2005: Cho-Hwa Liao; Shiow-Lin Pan; Jih-Hwa Guh; Ya-Ling Chang; Hui-Chen Pai; Chun-Hung Lin; Che-Ming Teng
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo.
Carcinogenesis 2005;26(5):968-75.
2005: Shih-Wei Wang; Shiow-Lin Pan; Jih-Hwa Guh; Hui-Ling Chen; Dong-Ming Huang; Ya-Ling Chang; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
The Journal of pharmacology and experimental therapeutics 2005;312(3):917-25.
2005: Yao-Ting Huang; Dong-Ming Huang; Jih-Hwa Guh; I-Li Chen; Cherng-Chyi Tzeng; Che-Ming Teng
CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.
The Journal of biological chemistry 2005;280(4):2771-9.
2005: Yu-Chun Huang; Jih-Hwa Guh; Ya-Ching Shen; Che-Ming Teng
Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia.
Journal of biomedical science 2005;12(2):335-45.
2005: Yu-Chun Huang; Jih-Hwa Guh; Che-Ming Teng
Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity.
Journal of biomedical science 2005;12(1):113-21.
2005: Ya-Ching Shen; Kuen-Ching Cheng; Yun-Chi Lin; Yuan-Bin Cheng; Ashraf Taha Khalil; Jih-Hwa Guh; Ching-Te Chien; Che-Ming Teng; Yao-To Chang
Three new taxane diterpenoids from Taxus sumatrana.
Journal of natural products 2005;68(1):90-3.
2005: Ashraf Taha Khalil; Ya-Ching Shen; Jih-Hwa Guh; Shi-Yie Cheng
Two new sesquiterpene lactones from Ixeris chinensis.
Chemical & pharmaceutical bulletin 2005;53(1):15-7.
2005: Dong-Ming Huang; Jih-Hwa Guh; Yao-Ting Huang; Shih-Chieh Chueh; Po-Cheng Chiang; Che-Ming Teng
Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine.
The Journal of urology 2005;173(1):256-61.
2004: Chieh-Yu Peng; Shiow-Lin Pan; Jih-Hwa Guh; Yi-Nan Liu; Ya-Ling Chang; Sheng-Chu Kuo; Fang-Yu Lee; Che-Ming Teng
The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury.
Thrombosis and haemostasis 2004;92(6):1232-9.
2004: Dong-Ming Huang; Ya-Ching Shen; Chi Wu; Yao-Ting Huang; Fan-Lu Kung; Che-Ming Teng; Jih-Hwa Guh
Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells.
European journal of pharmacology 2004;503(1-3):17-24.
2004: Guey-Mei Jow; Yang-Chang Wu; Jih-Hwa Guh; Che-Ming Teng
Armepavine oxalate induces cell death on CCRF-CEM leukemia cell line through an apoptotic pathway.
Life sciences 2004;75(5):549-57.
2004: Cho-Hwa Liao; Shiow-Lin Pan; Jih-Hwa Guh; Che-Ming Teng
Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells.
Biochemical pharmacology 2004;67(11):2031-8.
2004: Yu-Chun Huang; Jih-Hwa Guh; Che-Ming Teng
Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes.
Life sciences 2004;75(1):35-49.
2004: Dong-Ming Huang; Jih-Hwa Guh; Shih-Chieh Chueh; Che-Ming Teng
Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells.
The Prostate 2004;59(3):260-7.
2004: Ya-Ching Shen; Yuan-Bin Cheng; Yu-Chi Lin; Jih-Hwa Guh; Che-Ming Teng; Chin-Lien Ko
New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis.
Journal of natural products 2004;67(4):542-6.
2004: Ya-Ching Shen; Chih-Hsin Wang; Yuan-Bin Cheng; Li-Tang Wang; Jih-Hwa Guh; Ching-Te Chien; Ashraf Taha Khalil
New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea.
Journal of natural products 2004;67(3):316-21.
2004: Yao-Ting Huang; Shih-Chieh Chueh; Che-Ming Teng; Jih-Hwa Guh
Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.
Biochemical pharmacology 2004;67(4):727-33.
2004: Shiow-Lin Pan; Jih-Hwa Guh; Ya L Chang; Sheng-Chu Kuo; Fang Y Lee; Che-Ming Teng
YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells.
Cardiovascular research 2004;61(1):152-8.
2004: Ya-Ching Shen; Li-Tang Wang; Chih-Hsin Wang; Ashraf Taha Khalil; Jih-Hwa Guh
Two new cytotoxic clerodane diterpenoids from Casearia membranacea.
Chemical & pharmaceutical bulletin 2004;52(1):108-10.
2003: C C Chou; Shiow-Lin Pan; Che-Ming Teng; Jih-Hwa Guh
Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(5):403-12.
2003: Tsann-Long Hwang; Chin-Chung Wu; Jih-Hwa Guh; Che-Ming Teng
Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway.
Biochemical pharmacology 2003;66(1):149-56.
2003: Jui-Yi Chou; Shau-Yan Lai; Shiow-Lin Pan; Guey-Mei Jow; Ji-Wang Chern; Jih-Hwa Guh
Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells.
Biochemical pharmacology 2003;66(1):115-24.
2003: Shiow-Lin Pan; Ying-Wen Huang; Jih-Hwa Guh; Ya-Ling Chang; Chieh-Yu Peng; Che-Ming Teng
Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats.
Biochemical pharmacology 2003;65(11):1897-905.
2003: Shiow-Lin Pan; Jih-Hwa Guh; Ying-Wen Huang; Ji-Wang Chern; Jui-Yi Chou; Che-Ming Teng
Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells.
The Journal of urology 2003;169(2):724-9.
2002: Jin-Cherng Lien; Fang-Yu Lee; Li-Jiau Huang; Shiow-Lin Pan; Jih-Hwa Guh; Che-Ming Teng; Sheng-Chu Kuo
1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.
Journal of medicinal chemistry 2002;45(23):4947-9.
2002: Shiow-Lin Pan; Jih-Hwa Guh; Ying-Wen Huang; Ya-Ling Chang; Chiung-Yun Chang; Li-Jiau Huang; Sheng-Chu Kuo; Che-Ming Teng
Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde.
Journal of biomedical science 2002;9(6 Pt 2):622-30.
2002: Dong-Ming Huang; Jih-Hwa Guh; Yao-Ting Huang; Shih-Chieh Chueh; Hui-Po Wang; Che-Ming Teng
Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer.
Journal of biomedical science 2002;9(5):443-52.
2002: Cho-Hwa Liao; Cho-Hwa Liao; Ya-Ling Chang; Jih-Hwa Guh; Shen-Chu Kuo; Li-Jiau Huang; Che-Ming Teng
Effect of a potent cyclooxygenase inhibitor, 5-ethyl-4-methoxy-2-phenylquinoline (KTC-5), on human platelets.
The Journal of pharmacy and pharmacology 2002;54(7):967-74.
2002: Shih-Chieh Chueh; Ji-Wang Chern; Chee-Min Choong; Jih-Hwa Guh; Che-Ming Teng
Characterization of some novel alpha 1-adrenoceptor antagonists in human hyperplastic prostate.
European journal of pharmacology 2002;445(1-2):125-31.
2001: Shih-Chieh Chueh; Jih-Hwa Guh; Jun Chen; Ming-Kuen Lai; Che-Ming Teng
Dual effects of ouabain on the regulation of proliferation and apoptosis in human prostatic smooth muscle cells.
The Journal of urology 2001;166(1):347-53.
2001: Yu-Chun Huang; Jih-Hwa Guh; ZJ Cheng; Ya-Ling Chang; TL Hwang; Chang-Hui Liao; Cherng-Chyi Tzeng; Che-Ming Teng
Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: involvement of IkappaB-alpha stabilization.
European journal of pharmacology 2001;418(1-2):133-9.
2001: Yu-Chun Huang; Jih-Hwa Guh; ZJ Cheng; Ya-Ling Chang; TL Hwang; CN Lin; Che-Ming Teng
Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells.
Life sciences 2001;68(21):2435-47.
2000: Jih-Hwa Guh; Shih-Chieh Chueh; Che-Ming Teng
Effects of ouabain on tension response and [3H]noradrenaline release in human prostate.
The Journal of urology 2000;163(1):338-42.
1999: Jih-Hwa Guh; C H Hsieh; Che-Ming Teng
Investigation of the effects of some alkaloidal alpha1-adrenoceptor antagonists on human hyperplastic prostate.
European journal of pharmacology 1999;374(3):503-10.
1998: Jih-Hwa Guh; Shih-Chieh Chueh; TL Hwang; J Chen; Che-Ming Teng
Cell proliferation in human prostatic smooth muscle cells involves the modulation of protein kinase C isozymes.
European journal of pharmacology 1998;359(2-3):281-4.
1998: ZJ Cheng; Jih-Hwa Guh; F Y Lee; Sheng-Chu Kuo
Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.
The Biochemical journal 1998;335 ( Pt 1)():191.
1998: Jih-Hwa Guh; T L Hwang; F N Ko; Shih-Chieh Chueh; M K Lai; C M Teng
Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor.
Molecular pharmacology 1998;53(3):467-74.
1996: S M Yu; S Y Tsai; Jih-Hwa Guh; F N Ko; C M Teng; J T Ou
Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells.
Circulation 1996;94(3):547-54.
1996: Shih-Chieh Chueh; Jih-Hwa Guh; Jun Chen; Ming-Kuen Lai; FN Ko; C M Teng
Inhibition by tamsulosin of tension responses of human hyperplastic prostate to electrical field stimulation.
European journal of pharmacology 1996;305(1-3):177-80.
1996: Jih-Hwa Guh; FN Ko; Shih-Chieh Chueh; Ming-Kuen Lai; C M Teng
Ouabain-induced increases in resting tone of human hyperplastic prostate following repeated noradrenaline and electrical field stimulation.
British journal of pharmacology 1996;117(8):1716-20.
1996: Jih-Hwa Guh; S M Yu; FN Ko; Tian-Shung Wu; C M Teng
Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens.
European journal of pharmacology 1996;298(2):191-7.
1995: Jih-Hwa Guh; FN Ko; S M Yu; Y C Wu; C M Teng
Pharmacological evaluation of N-methyl-actinodaphnine, a new vascular alpha-adrenoceptor antagonist, isolated from Illigera luzonensis.
European journal of pharmacology 1995;279(1):33-41.
1995: Jih-Hwa Guh; Shih-Chieh Chueh; FN Ko; C M Teng
Characterization of alpha 1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation.
British journal of pharmacology 1995;115(1):142-6.
1995: Jih-Hwa Guh; FN Ko; T T Jong; C M Teng
Antiplatelet effect of gingerol isolated from Zingiber officinale.
The Journal of pharmacy and pharmacology 1995;47(4):329-32.
1995: S M Yu; ZJ Cheng; Jih-Hwa Guh; F Y Lee; Sheng-Chu Kuo
Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.
The Biochemical journal 1995;306 ( Pt 3)():787-92.
1994: C M Teng; Jih-Hwa Guh; FN Ko
Functional identification of alpha 1-adrenoceptor subtypes in human prostate: comparison with those in rat vas deferens and spleen.
European journal of pharmacology 1994;265(1-2):61-6.
1994: FN Ko; Jih-Hwa Guh; S M Yu; Y S Hou; Y C Wu; C M Teng
(-)-Discretamine, a selective alpha 1D-adrenoceptor antagonist, isolated from Fissistigma glaucescens.
British journal of pharmacology 1994;112(4):1174-80.