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Sylvie Guichard

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Maciej Kaliszczak; Dyeison Antonow; Katan I Patel; Philip Howard; Duncan I Jodrell; David E Thurston; Sylvie M Guichard
Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters.
Kate Connolly; Richard Mitter; Morwenna Muir; Duncan I Jodrell; Sylvie M Guichard
Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro.
Katan Patel; Sylvie M Guichard; Duncan I Jodrell
Simultaneous determination of decitabine and vorinostat (Suberoylanalide hydroxamic acid, SAHA) by liquid chromatography tandem mass spectrometry for clinical studies.

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All Publications

2010: Maciej Kaliszczak; Dyeison Antonow; Katan I Patel; Philip Howard; Duncan I Jodrell; David E Thurston; Sylvie M Guichard
Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters.
The AAPS journal 2010;12(4):617-27.
2009: Kate Connolly; Richard Mitter; Morwenna Muir; Duncan I Jodrell; Sylvie M Guichard
Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro.
Cancer chemotherapy and pharmacology 2009;64(2):307-16.
2008: Katan Patel; Sylvie M Guichard; Duncan I Jodrell
Simultaneous determination of decitabine and vorinostat (Suberoylanalide hydroxamic acid, SAHA) by liquid chromatography tandem mass spectrometry for clinical studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;863(1):19-25.
2008: Sylvie M Guichard; Janet S Macpherson; Iain Mayer; Eilidh Reid; M Muir; Michael Dodds; Susan Alexander; Duncan I Jodrell
Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity.
European journal of cancer (Oxford, England : 1990) 2008;44(2):310-7.
2007: Sylvie M Guichard; M L Hua; P Kang; Janet S Macpherson; Duncan I Jodrell
Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model.
Cancer chemotherapy and pharmacology 2007;60(5):651-60.
2007: Lesley Stark; Kirsten Reid; Owen J Sansom; Farhat V Din; Sylvie M Guichard; Iain Mayer; Duncan I Jodrell; Alan R Clarke; Malcolm G Dunlop
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer.
Carcinogenesis 2007;28(5):968-76.
2006: Lars M Wagner; Rebecca A Burger; Sylvie M Guichard; Susana C Raimondi; Victor M Santana; Wayne L Furman; Phillip Barnette; Mary K Danks
Pilot study to evaluate MYCN expression as a neuroblastoma cell marker to detect minimal residual disease by RT-PCR.
Journal of pediatric hematology/oncology 2006;28(10):635-41.
2006: Stéphanie Arnould; Victoria J Spanswick; Janet S Macpherson; John A Hartley; David E Thurston; Duncan I Jodrell; Sylvie M Guichard
Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.
Molecular cancer therapeutics 2006;5(6):1602-9.
2006: Janet S Macpherson; Duncan I Jodrell; Sylvie M Guichard
Validation of real-time reverse-transcription-polymerase chain reaction for quantification of capecitabine-metabolizing enzymes.
Analytical biochemistry 2006;350(1):71-80.
2006: Sylvie M Guichard; R Else; E Reid; Benjamin Zeitlin; Rhona E Aird; M Muir; M Dodds; H Fiebig; Peter J Sadler; Duncan I Jodrell
Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds.
Biochemical pharmacology 2006;71(4):408-15.
2005: Fuyi Wang; Abraha Habtemariam; Erwin P L van der Geer; Rafael Fernández; Michael Melchart; Robert J Deeth; Rhona E Aird; Sylvie M Guichard; Francesca P A Fabbiani; Patricia Lozano-Casal; Iain D H Oswald; Duncan I Jodrell; Simon Parsons; Peter J Sadler
Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18269-74.
2005: Jean-Pierre Delord; Cuider Allal; M Canal; Eliane Mery; Philippe Rochaix; Isabelle Hennebelle; Anne Pradines; Etienne Chatelut; Roland Bugat; Sylvie M Guichard; Pierre Canal
Selective inhibition of HER2 inhibits AKT signal transduction and prolongs disease-free survival in a micrometastasis model of ovarian carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(12):1889-97.
2005: Sylvie M Guichard; Iain Mayer; Duncan I Jodrell
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;826(1-2):232-7.
2005: Sylvie M Guichard; Janet S Macpherson; David E Thurston; Duncan I Jodrell
Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
European journal of cancer (Oxford, England : 1990) 2005;41(12):1811-8.
2005: Jane M Sewell; Iain Mayer; Simon P Langdon; John F Smyth; Duncan I Jodrell; Sylvie M Guichard
The mechanism of action of Kahalalide F: variable cell permeability in human hepatoma cell lines.
European journal of cancer (Oxford, England : 1990) 2005;41(11):1637-44.
2005: Richard L Hayward; Q C Schornagel; R Tente; Janet S Macpherson; Rhona E Aird; Sylvie M Guichard; Abraha Habtemariam; Peter J Sadler; Duncan I Jodrell
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175.
Cancer chemotherapy and pharmacology 2005;55(6):577-83.
2003: Stéphanie Arnould; Isabelle Hennebelle; Pierre Canal; Roland Bugat; Sylvie M Guichard
Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines.
European journal of cancer (Oxford, England : 1990) 2003;39(1):112-9.
2002: Stéphanie Arnould; Sylvie M Guichard; Isabelle Hennebelle; Georges Cassar; Roland Bugat; Pierre Canal
Contribution of apoptosis in the cytotoxicity of the oxaliplatin-irinotecan combination in the HT29 human colon adenocarcinoma cell line.
Biochemical pharmacology 2002;64(8):1215-26.
2002: Lars M Wagner; Sylvie M Guichard; Rebecca A Burger; Christopher L Morton; Charles M Straign; Richard A Ashmun; Linda C Harris; Peter J Houghton; Philip Potter; Mary K Danks
Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients.
Cancer research 2002;62(17):5001-7.
2002: Elisabeth Rouits; Sylvie M Guichard; Pierre Canal; Etienne Chatelut
Non-linear pharmacokinetics of irinotecan in mice.
Anti-cancer drugs 2002;13(6):631-5.
2001: Sylvie M Guichard; Ashraf Montazeri; Etienne Chatelut; Isabelle Hennebelle; Roland Bugat; Pierre Canal
Schedule-dependent activity of topotecan in OVCAR-3 ovarian carcinoma xenograft: pharmacokinetic and pharmacodynamic evaluation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):3222-8.
2001: Sylvie M Guichard; Stéphanie Arnould; Isabelle Hennebelle; Roland Bugat; Pierre Canal
Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo.
Anti-cancer drugs 2001;12(9):741-51.
2001: M M Meck; Monika Wierdl; Lars M Wagner; Rebecca A Burger; Sylvie M Guichard; Erik J Krull; Linda C Harris; Philip Potter; Mary K Danks
A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11.
Cancer research 2001;61(13):5083-9.
2001: J Thompson; Sylvie M Guichard; Pamela J Cheshire; LB Richmond; CA Poquette; S T Ragsdale; B Webber; R Lorsbach; Mary K Danks; Peter J Houghton
Development, characterization and therapy of a disseminated model of childhood neuroblastoma in SCID mice.
Cancer chemotherapy and pharmacology 2001;47(3):211-21.
2001: Sylvie M Guichard; Pierre Canal
[New pharmacology techniques and methods in oncology].
Bulletin du cancer 2001;88(1):85-9.
2000: Isabelle Hennebelle; C Terret; Etienne Chatelut; Roland Bugat; Pierre Canal; Sylvie M Guichard
Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity.
Anti-cancer drugs 2000;11(6):465-70.
2000: CA Pawlik; R V Iyengar; Erik J Krull; S E Mason; R Khanna; Linda C Harris; Philip Potter; Mary K Danks; Sylvie M Guichard
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;1(5 Pt 1):457-63.
2000: Rosine Guimbaud; Sylvie M Guichard; C Dusseau; V Bertrand; T Aparicio; Isabelle Lochon; Etienne Chatelut; Daniel Couturier; Roland Bugat; Stanislas Chaussade; Pierre Canal
Dihydropyrimidine dehydrogenase activity in normal, inflammatory and tumour tissues of colon and liver in humans.
Cancer chemotherapy and pharmacology 2000;45(6):477-82.
1999: Pamela P McKenzie; Sylvie M Guichard; David S Middlemas; Richard A Ashmun; Mary K Danks; Linda C Harris
Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4199-207.
1999: Sylvie M Guichard; Mary K Danks
Topoisomerase enzymes as drug targets.
Current opinion in oncology 1999;11(6):482-9.
1999: Sylvie M Guichard; C Terret; Isabelle Hennebelle; Isabelle Lochon; P Chevreau; E Frétigny; Janick Selves; Etienne Chatelut; Roland Bugat; Pierre Canal
CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues.
British journal of cancer 1999;80(3-4):364-70.
1998: Pierre Canal; Etienne Chatelut; Sylvie M Guichard
Practical treatment guide for dose individualisation in cancer chemotherapy.
Drugs 1998;56(6):1019-38.
1998: Sylvie M Guichard; Christopher L Morton; Erik J Krull; Clinton F Stewart; Mary K Danks; Philip Potter
Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):3089-94.
1998: Sylvie M Guichard; Isabelle Hennebelle; Roland Bugat; Pierre Canal
Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line.
Biochemical pharmacology 1998;55(5):667-76.
1998: Sylvie M Guichard; Etienne Chatelut; Isabelle Lochon; Roland Bugat; Mondher Mahjoubi; Pierre Canal
Comparison of the pharmacokinetics and efficacy of irinotecan after administration by the intravenous versus intraperitoneal route in mice.
Cancer chemotherapy and pharmacology 1998;42(2):165-70.
1997: Sylvie M Guichard; D Cussac; Isabelle Hennebelle; Roland Bugat; Pierre Canal
Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo.
International journal of cancer. Journal international du cancer 1997;73(5):729-34.
1995: A Nehmé; N Albin; M J Caliaro; Sylvie M Guichard; Suzanne Jozan; A M Julia; Roland Bugat; Pierre Canal
Mechanism of interaction between cisplatin and human recombinant interferon gamma in human ovarian-cancer cell lines.
International journal of cancer. Journal international du cancer 1995;61(5):643-8.
1994: M J Caliaro; C Marmouget; Sylvie M Guichard; P Mazars; Annie Valette; A Moisand; Roland Bugat; Suzanne Jozan
Response of four human ovarian carcinoma cell lines to all-trans retinoic acid: relationship with induction of differentiation and retinoic acid receptor expression.
International journal of cancer. Journal international du cancer 1994;56(5):743-8.
1993: Pierre Canal; M Attal; Etienne Chatelut; Sylvie M Guichard; F Huguet; C Muller; daniel schlaifer; G Laurent; Georges Houin; Roland Bugat
Plasma and cellular pharmacokinetics of mitoxantrone in high-dose chemotherapeutic regimen for refractory lymphomas.
Cancer research 1993;53(20):4850-4.