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Theresa Guise

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Patricia Juárez; Alain Mauviel; Ryan C McKenna; Khalid S Mohammad; Maria Niewolna; Xiang H Peng; Juan Juan Yin; John M Chirgwin; Holly W Davis; Pierrick G J Fournier; Delphine Javelaud; Theresa A Guise
Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Jeroen T Buijs; Patricia Juárez; Theresa A Guise
Therapeutic strategies to target TGF-β in the treatment of bone metastases.
Gregory A Clines; Katrina L Clines; Jessica M Grunda; C Ryan McKenna; Christopher R McKibbin; Khalid S Mohammad; Maryla Niewolna; Larry J Suva; Masashi Yanagisawa; John M Chirgwin; Theresa A Guise
Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.

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All Publications

2012: Patricia Juárez; Alain Mauviel; Ryan C McKenna; Khalid S Mohammad; Maria Niewolna; Xiang H Peng; Juan Juan Yin; John M Chirgwin; Holly W Davis; Pierrick G J Fournier; Delphine Javelaud; Theresa A Guise
Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Cancer research 2012;72(23):6247-56.
2011: Jeroen T Buijs; Patricia Juárez; Theresa A Guise
Therapeutic strategies to target TGF-β in the treatment of bone metastases.
Current pharmaceutical biotechnology 2011;12(12):2121-37.
2011: Gregory A Clines; Katrina L Clines; Jessica M Grunda; C Ryan McKenna; Christopher R McKibbin; Khalid S Mohammad; Maryla Niewolna; Larry J Suva; Masashi Yanagisawa; John M Chirgwin; Theresa A Guise
Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(10):2523-36.
2011: Delphine Javelaud; Vasileia I Alexaki; Sylviane Dennler; Theresa A Guise; Khalid S Mohammad; Alain Mauviel
TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.
Cancer research 2011;71(17):5606-10.
2011: Haixiang Liang; Shen-Ying Ma; Khalid Mohammad; Theresa A Guise; Gary Balian; Francis H Shen
The reaction of bone to tumor growth from human breast cancer cells in a rat spine single metastasis model.
Spine 2011;36(7):497-504.
2011: Khalid S Mohammad; Delphine Javelaud; Pierrick G J Fournier; Maria Niewolna; C Ryan McKenna; Xiang H Peng; Vu Duong; Lauren K Dunn; Alain Mauviel; Theresa A Guise
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Cancer research 2011;71(1):175-84.
2011: Patricia Juárez; Theresa A Guise
TGF-β in cancer and bone: implications for treatment of bone metastases.
Bone 2011;48(1):23-9.
2010: Theresa A Guise
Examining the metastatic niche: targeting the microenvironment.
Seminars in oncology 2010;37 Suppl 2():S2-14.
2010: Vasileia-Ismini Alexaki; Delphine Javelaud; Leon C L Van Kempen; Khalid S Mohammad; Sylviane Dennler; Flavie Luciani; Keith S Hoek; Patricia Juàrez; James S Goydos; Pierrick J Fournier; Claire Sibon; Corine Bertolotto; Franck Verrecchia; Simon Saule; Veronique Delmas; Robert Ballotti; Lionel Larue; philippe saiag; Theresa A Guise; Alain Mauviel
GLI2-mediated melanoma invasion and metastasis.
Journal of the National Cancer Institute 2010;102(15):1148-59.
2010: Patricia Juárez; Theresa A Guise
Tgf-Beta pathway as a therapeutic target in bone metastases.
Current pharmaceutical design 2010;16(11):1301-12.
2009: Khalid S Mohammad; Pierrick G Fournier; Theresa A Guise; John M Chirgwin
Agents targeting prostate cancer bone metastasis.
Anti-cancer agents in medicinal chemistry 2009;9(10):1079-88.
2009: Theresa A Guise; Regis O'Keefe; R Lor Randall; Richard M Terek
Molecular biology and therapeutics in musculoskeletal oncology.
The Journal of bone and joint surgery. American volume 2009;91(3):724-32.
2009: Lauren K Dunn; Khalid S Mohammad; Pierrick G J Fournier; C Ryan McKenna; Holly W Davis; Maria Niewolna; Xiang Hong Peng; John M Chirgwin; Theresa A Guise
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.
PloS one 2009;4(9):e6896.
2009: Khalid S Mohammad; Carol G Chen; Guive Balooch; Elizabeth Stebbins; C Ryan McKenna; Holly Davis; Maria Niewolna; Xiang Hong Peng; Daniel H N Nguyen; Sophi S Ionova-Martin; John W Bracey; William R Hogue; Darren H Wong; Robert O Ritchie; Larry J Suva; Rik Derynck; Theresa A Guise; Tamara Alliston
Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.
PloS one 2009;4(4):e5275.
2009: Sue A Brown; Theresa A Guise
Cancer treatment-related bone disease.
Critical reviews in eukaryotic gene expression 2009;19(1):47-60.
2008: Theresa A Guise
Antitumor effects of bisphosphonates: promising preclinical evidence.
Cancer treatment reviews 2008;34 Suppl 1():S19-24.
2008: Khalid S Mohammad; John M Chirgwin; Theresa A Guise
Assessing new bone formation in neonatal calvarial organ cultures.
Methods in molecular biology (Clifton, N.J.) 2008;455():37-50.
2008: Gregory A Clines; Theresa A Guise
Molecular mechanisms and treatment of bone metastasis.
Expert reviews in molecular medicine 2008;10():e7.
2007: John M Chirgwin; Theresa A Guise
Skeletal metastases: decreasing tumor burden by targeting the bone microenvironment.
Journal of cellular biochemistry 2007;102(6):1333-42.
2007: Sue A Brown; Gregory A Clines; Theresa A Guise
Local effects of malignancy on bone.
Current opinion in endocrinology, diabetes, and obesity 2007;14(6):436-41.
2007: Lauren A Kingsley; Pierrick G J Fournier; John M Chirgwin; Theresa A Guise
Molecular biology of bone metastasis.
Molecular cancer therapeutics 2007;6(10):2609-17.
2007: Sue A Brown; Theresa A Guise
Cancer-associated bone disease.
Current osteoporosis reports 2007;5(3):120-7.
2007: Pierrick G J Fournier; Theresa A Guise
BMP7: a new bone metastases prevention?
The American journal of pathology 2007;171(3):739-43.
2007: Lauren A Kingsley; John M Chirgwin; Theresa A Guise
Breaking new ground to build bone.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10753-4.
2007: Sue A Brown; Theresa A Guise
Drug insight: the use of bisphosphonates for the prevention and treatment of osteoporosis in men.
Nature clinical practice. Urology 2007;4(6):310-20.
2007: Delphine Javelaud; Khalid S Mohammad; Christopher R McKenna; Pierrick Fournier; Flavie Luciani; Maryla Niewolna; Jocelyne André; Véronique Delmas; Lionel Larue; Theresa A Guise; Alain Mauviel
Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis.
Cancer research 2007;67(5):2317-24.
2007: Laurent Bartholin; Lisa L Wessner; John M Chirgwin; Theresa A Guise
The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells.
Cancer letters 2007;246(1-2):230-6.
2007: Gregory A Clines; Khalid S Mohammad; Yongde Bao; Owen W Stephens; Larry J Suva; John D Shaughnessy; Jay W Fox; John M Chirgwin; Theresa A Guise
Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):486-98.
2006: V A Siclari; Theresa A Guise; John M Chirgwin
Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases.
Cancer metastasis reviews 2006;25(4):621-33.
2006: Theresa A Guise
Bone loss and fracture risk associated with cancer therapy.
The oncologist 2006;11(10):1121-31.
2006: Theresa A Guise; Khalid S Mohammad; Gregory A Clines; Elizabeth G Stebbins; Darren H Wong; Linda S Higgins; Robert L Vessella; Eva Corey; Susan Padalecki; Larry J Suva; John M Chirgwin
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 2):6213s-6216s.
2006: Allan Lipton; James R Berenson; Jean-Jacques Body; Brendan F Boyce; Oyvind S Bruland; Michael A Carducci; Charles S Cleeland; Denis R Clohisy; Robert E Coleman; Richard J Cook; Theresa A Guise; Roger N Pearse; Trevor J Powles; Michael J Rogers; David G Roodman; Matthew R Smith; Larry J Suva; Robert L Vessella; Katherine N Weilbaecher; Laura King
Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 2):6209s-6212s.
2006: Pierrick G J Fournier; John M Chirgwin; Theresa A Guise
New insights into the role of T cells in the vicious cycle of bone metastases.
Current opinion in rheumatology 2006;18(4):396-404.
2006: Theresa A Guise
Do markers of bone turnover predict clinical outcome in patients with bone metastases?
Nature clinical practice. Endocrinology & metabolism 2006;2(5):258-9.
2006: John M Chirgwin; Theresa A Guise
Does prostate-specific antigen contribute to bone metastases?
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1395-7.
2006: Enrique Zudaire; Alfredo Martínez; Mercedes Garayoa; Rubén Pío; Gurmeet Kaur; Michael R Woolhiser; Dean D Metcalfe; William A Hook; Reuben P Siraganian; Theresa A Guise; John M Chirgwin; Frank Cuttitta
Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.
The American journal of pathology 2006;168(1):280-91.
2005: Manali S Bendre; Aaron G Margulies; Brandon Walser; Nisreen S Akel; Sudeepa Bhattacharrya; Robert A Skinner; Frances L Swain; Vishnu Ramani; Khalid S Mohammad; Lisa L Wessner; Alfredo Martinez; Theresa A Guise; John M Chirgwin; Dana Gaddy; Larry J Suva
Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway.
Cancer research 2005;65(23):11001-9.
2005: Gregory A Clines; Theresa A Guise
Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone.
Endocrine-related cancer 2005;12(3):549-83.
2005: Brian Titus; Henry F Frierson; Mark Conaway; Keith Ching; Theresa A Guise; John M Chirgwin; Garret M Hampton; Dan Theodorescu
Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2.
Cancer research 2005;65(16):7320-7.
2005: Wende Kozlow; Theresa A Guise
Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy.
Journal of mammary gland biology and neoplasia 2005;10(2):169-80.
2005: Theresa A Guise; Wende M Kozlow; Ailleen Heras-Herzig; Susan Padalecki; Juan Juan Yin; John M Chirgwin
Molecular mechanisms of breast cancer metastases to bone.
Clinical breast cancer 2005;5 Suppl(2):S46-53.
2004: John M Chirgwin; Khalid S Mohammad; Theresa A Guise
Tumor-bone cellular interactions in skeletal metastases.
Journal of musculoskeletal & neuronal interactions 2004;4(3):308-18.
2004: Gregory A Clines; Theresa A Guise
Mechanisms and treatment for bone metastases.
Clinical advances in hematology & oncology : H&O 2004;2(5):295-302.
2004: Bernhard Maier; Wendy Gluba; Brian Bernier; Terry Turner; Khalid Mohammad; Theresa A Guise; Ann Sutherland; Michael O Thorner; Heidi Scrable
Modulation of mammalian life span by the short isoform of p53.
Genes & development 2004;18(3):306-19.
2004: Theresa A Guise; Khalid S Mohammad
Endothelins in bone cancer metastases.
Cancer treatment and research 2004;118():197-212.
2003: John M Chirgwin; Theresa A Guise
Interactions between tumor and bone alter the phenotypes of both.
Journal of musculoskeletal & neuronal interactions 2003;3(4):278-81; discussion 292-4.
2003: Khalid S Mohammad; Theresa A Guise
Mechanisms of osteoblastic metastases: role of endothelin-1.
Clinical orthopaedics and related research 2003;(415 Suppl):S67-74.
2003: Theresa A Guise; John M Chirgwin
Transforming growth factor-beta in osteolytic breast cancer bone metastases.
Clinical orthopaedics and related research 2003;(415 Suppl):S32-8.
2003: Theresa A Guise; John M Chirgwin
Role of bisphosphonates in prostate cancer bone metastases.
Seminars in oncology 2003;30(5):717-23.
2003: Juan Juan Yin; Khalid S Mohammad; Sanna M Käkönen; Stephen E Harris; J Ruth Wu-Wong; Jerry L Wessale; Robert J Padley; I Ross Garrett; John M Chirgwin; Theresa A Guise
A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10954-9.
2003: Susan Padalecki; K S Weldon; Xavier T Reveles; C L Buller; Barry Grubbs; Yong Cui; Juan Juan Yin; D C Hall; B T Hummer; Bernard E Weissman; Mark Dallas; Theresa A Guise; Robin J Leach; Teresa Johnson-Pais
Chromosome 18 suppresses prostate cancer metastases.
Urologic oncology 2003;21(5):366-73.
2003: Yibin Kang; Peter M Siegel; Weiping Shu; Marija Drobnjak; Sanna M Kakonen; Carlos Cordón-Cardo; Theresa A Guise; Joan Massagué
A multigenic program mediating breast cancer metastasis to bone.
Cancer cell 2003;3(6):537-49.
2003: Claudine H Kos; Andrew C Karaplis; Ji-Bin Peng; Matthias A Hediger; David Goltzman; Khalid S Mohammad; Theresa A Guise; Martin R Pollak
The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.
The Journal of clinical investigation 2003;111(7):1021-8.
2003: Theresa A Guise; Juan Juan Yin; Khalid S Mohammad
Role of endothelin-1 in osteoblastic bone metastases.
Cancer 2003;97(3 Suppl):779-84.
2002: Theresa A Guise
The vicious cycle of bone metastases.
Journal of musculoskeletal & neuronal interactions 2002;2(6):570-2.
2002: Sanna-Maria Kakonen; Katri S Selander; John M Chirgwin; Juan Juan Yin; Suzanne Burns; Wayne Rankin; Barry Grubbs; Mark Dallas; Yong Cui; Theresa A Guise
Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways.
The Journal of biological chemistry 2002;277(27):24571-8.
2002: Theresa A Guise; Juan Juan Yin; RJ Thomas; Mark Dallas; Yong Cui; Matthew T Gillespie
Parathyroid hormone-related protein (PTHrP)-(1-139) isoform is efficiently secreted in vitro and enhances breast cancer metastasis to bone in vivo.
Bone 2002;30(5):670-6.
2002: Susan Padalecki; Theresa A Guise
Actions of bisphosphonates in animal models of breast cancer.
Breast cancer research : BCR 2002;4(1):35-41.
2000: Theresa A Guise
Molecular mechanisms of osteolytic bone metastases.
Cancer 2000;88(12 Suppl):2892-8.
2000: John M Chirgwin; Theresa A Guise
Molecular mechanisms of tumor-bone interactions in osteolytic metastases.
Critical reviews in eukaryotic gene expression 2000;10(2):159-78.
1999: RJ Thomas; Theresa A Guise; Juan Juan Yin; Jan Elliott; Nicole J Horwood; T John Martin; Matthew T Gillespie
Breast cancer cells interact with osteoblasts to support osteoclast formation.
Endocrinology 1999;140(10):4451-8.
1999: BF Boyce; Toshiyuki Yoneda; Theresa A Guise
Factors regulating the growth of metastatic cancer in bone.
Endocrine-related cancer 1999;6(3):333-47.
1999: P Lemieux; J Harvey; Theresa A Guise; Mark Dallas; Steffi Oesterreich; J j Yin; Katri S Selander; S Fuqua
Low cell motility induced by hsp27 overexpression decreases osteolytic bone metastases of human breast cancer cells in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(9):1570-5.
1999: Gregory R Mundy; Theresa A Guise
Hormonal control of calcium homeostasis.
Clinical chemistry 1999;45(8 Pt 2):1347-52.
1999: Juan Juan Yin; Katri S Selander; John M Chirgwin; Mark Dallas; Barry Grubbs; R Wieser; J Massagué; Gregory R Mundy; Theresa A Guise
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.
The Journal of clinical investigation 1999;103(2):197-206.
1998: Theresa A Guise; Gregory R Mundy
Cancer and bone.
Endocrine reviews 1998;19(1):18-54.
1997: Theresa A Guise
Parathyroid hormone-related protein and bone metastases.
Cancer 1997;80(8 Suppl):1572-80.
1997: H L Uy; Gregory R Mundy; BF Boyce; Beryl Story; C R Dunstan; Juan Juan Yin; David G Roodman; Theresa A Guise
Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.
Cancer research 1997;57(15):3194-9.
1996: Theresa A Guise; Juan Juan Yin; S D Taylor; Y Kumagai; Mark Dallas; B F Boyce; Toshiyuki Yoneda; Gregory R Mundy
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.
The Journal of clinical investigation 1996;98(7):1544-9.
1996: Theresa A Guise; Gregory R Mundy
Physiological and pathological roles of parathyroid hormone-related peptide.
Current opinion in nephrology and hypertension 1996;5(4):307-15.
1996: M Alsina; Theresa A Guise; David G Roodman
Cytokine regulation of bone cell differentiation.
Vitamins and hormones 1996;52():63-98.
1995: H L Uy; Theresa A Guise; J De La Mata; S D Taylor; Beryl Story; Mark Dallas; B F Boyce; Gregory R Mundy; David G Roodman
Effects of parathyroid hormone (PTH)-related protein and PTH on osteoclasts and osteoclast precursors in vivo.
Endocrinology 1995;136(8):3207-12.
1995: J de la Mata; H L Uy; Theresa A Guise; Beryl Story; B F Boyce; Gregory R Mundy; David G Roodman
Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.
The Journal of clinical investigation 1995;95(6):2846-52.
1995: Theresa A Guise; Gregory R Mundy
Clinical review 69: Evaluation of hypocalcemia in children and adults.
The Journal of clinical endocrinology and metabolism 1995;80(5):1473-8.
1993: Theresa A Guise; Toshiyuki Yoneda; A J Yates; Gregory R Mundy
The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro.
The Journal of clinical endocrinology and metabolism 1993;77(1):40-5.
1993: I Ross Garrett; Theresa A Guise; Lynda F Bonewald; R Chizzonite; Gregory R Mundy
Evidence that interleukin-1 mediates its effects on bone resorption via the 80 kilodalton interleukin-1 receptor.
Calcified tissue international 1993;52(6):438-41.
1993: Theresa A Guise; I Ross Garrett; Lynda F Bonewald; Gregory R Mundy
Interleukin-1 receptor antagonist inhibits the hypercalcemia mediated by interleukin-1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(5):583-7.
1992: Theresa A Guise; J M Chirgwin; G Favarato; B F Boyce; Gregory R Mundy
Chinese hamster ovarian cells transfected with human parathyroid hormone-related protein cDNA cause hypercalcemia in nude mice.
Laboratory investigation; a journal of technical methods and pathology 1992;67(4):477-85.