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William Gullick

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Publications

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Edith Blackburn; Ian R Brown; Samuel K W Chan; Mariana L Murphy; Stefania Zona; William J Gullick
A monoclonal antibody to the human HER3 receptor inhibits Neuregulin 1-beta binding and co-operates with Herceptin in inhibiting the growth of breast cancer derived cell lines.
Ming Wang; Carol M Trim; William J Gullick
Localisation of Neuregulin 1-β3 to different sub-nuclear structures alters gene expression.
Nandini V L Hayes; Edith Blackburn; Mary M Boyle; Graham A Russell; Teresa M Frost; Byron J T Morgan; William J Gullick
Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility.

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All Publications

2012: Edith Blackburn; Ian R Brown; Samuel K W Chan; Mariana L Murphy; Stefania Zona; William J Gullick
A monoclonal antibody to the human HER3 receptor inhibits Neuregulin 1-beta binding and co-operates with Herceptin in inhibiting the growth of breast cancer derived cell lines.
Breast cancer research and treatment 2012;134(1):53-9.
2011: Ming Wang; Carol M Trim; William J Gullick
Localisation of Neuregulin 1-β3 to different sub-nuclear structures alters gene expression.
Experimental cell research 2011;317(4):423-32.
2011: Nandini V L Hayes; Edith Blackburn; Mary M Boyle; Graham A Russell; Teresa M Frost; Byron J T Morgan; William J Gullick
Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility.
Endocrine-related cancer 2011;18(1):39-49.
2010: Emmet McIntyre; Edith Blackburn; Philip J Brown; Colin G Johnson; William J Gullick
The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer.
Breast cancer research and treatment 2010;122(1):105-10.
2009: William J Gullick
The epidermal growth factor system of ligands and receptors in cancer.
European journal of cancer (Oxford, England : 1990) 2009;45 Suppl 1():205-10.
2008: William J Gullick; Frank E Jones
The epidermal growth factor family of ligands and receptors grows and grows.
Journal of mammary gland biology and neoplasia 2008;13(2):157.
2008: Nandini V L Hayes; William J Gullick
The neuregulin family of genes and their multiple splice variants in breast cancer.
Journal of mammary gland biology and neoplasia 2008;13(2):205-14.
2008: Nandini V L Hayes; R J Newsam; Anthony J Baines; William J Gullick
Characterization of the cell membrane-associated products of the Neuregulin 4 gene.
Oncogene 2008;27(5):715-20.
2007: Nandini V L Hayes; Edith Blackburn; Laura V Smart; Mary M Boyle; Graham A Russell; Teresa M Frost; B J T Morgan; Anthony J Baines; William J Gullick
Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3147-55.
2007: CM McClelland; William J Gullick
Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity.
British journal of cancer 2007;96(2):284-9.
2006: Nicola Normanno; William J Gullick
Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application?
Endocrine-related cancer 2006;13(1):3-6.
2006: Catherine Marshall; Edith Blackburn; Mellissa Clark; stephen humphreys; William J Gullick
Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast.
Breast cancer research and treatment 2006;96(2):163-8.
2006: Samuel K Chan; Mark E Hill; William J Gullick
The role of the epidermal growth factor receptor in breast cancer.
Journal of mammary gland biology and neoplasia 2006;11(1):3-11.
2006: Nancy E Hynes; William J Gullick
Therapeutic targeting of signal transduction pathways and proteins in breast cancer.
Journal of mammary gland biology and neoplasia 2006;11(1):1-2.
2006: S K Chan; William J Gullick; M E Hill
Mutations of the epidermal growth factor receptor in non-small cell lung cancer -- search and destroy.
European journal of cancer (Oxford, England : 1990) 2006;42(1):17-23.
2005: L A Bazley; William J Gullick
The epidermal growth factor receptor family.
Endocrine-related cancer 2005;12 Suppl 1():S17-27.
2005: Katya Chobotova; Natalia Karpovich; Janet Carver; Sanjiv Manek; William J Gullick; David H Barlow; Helen J Mardon
Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells.
The Journal of clinical endocrinology and metabolism 2005;90(2):913-9.
2004: Colin G Johnson; Jacki Goldman; William J Gullick
Simulating complex intracellular processes using object-oriented computational modelling.
Progress in biophysics and molecular biology 2004;86(3):379-406.
2004: Huai-En Huang; Suet-Feung Chin; christophe ginestier; Valérie-Jeanne Bardou; José Adélaïde; N Gopalakrishna Iyer; Maria J Garcia; Jessica C M Pole; Grace Callagy; Stephen M Hewitt; William J Gullick; Jocelyne Jacquemier; Carlos Caldas; Max Chaffanet; Daniel Birnbaum; Paul A W Edwards
A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene.
Cancer research 2004;64(19):6840-4.
2004: Matthew Golding; Christiana Ruhrberg; Jennifer Sandle; William J Gullick
Mapping nucleolar and spliceosome localization sequences of neuregulin1-beta3.
Experimental cell research 2004;299(1):110-8.
2004: Mariana Dunn; Prakash Sinha; Rebecca Campbell; Edith Blackburn; Neil Levinson; Raj Rampaul; Tom Bates; stephen humphreys; William J Gullick
Co-expression of neuregulins 1, 2, 3 and 4 in human breast cancer.
The Journal of pathology 2004;203(2):672-80.
2004: Nandini Hayes; Elodie Howard-Cofield; William J Gullick
Green fluorescent protein as a tool to study epidermal growth factor receptor function.
Cancer letters 2004;206(2):129-35.
2003: CM McClelland; William J Gullick
Identification of surrogate markers for determining drug activity using proteomics.
Biochemical Society transactions 2003;31(Pt 6):1488-90.
2003: William J Gullick
c-erbB-4/HER4: friend or foe?
The Journal of pathology 2003;200(3):279-81.
2003: Achim A Jungbluth; Elisabeth Stockert; H-J Su Huang; Vincent P Collins; Keren Coplan; Kristin Iversen; Denise Kolb; Terrance J Johns; Andrew M Scott; William J Gullick; Gerd Ritter; Leonard Cohen; Matthew J Scanlan; Webster K Cavenee; Lloyd J Old; Webster K Cavanee
A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):639-44.
2002: Lynn M R Gilmour; Kenneth G Macleod; Alison McCaig; Jane M Sewell; William J Gullick; John F Smyth; Simon P Langdon
Neuregulin expression, function, and signaling in human ovarian cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3933-42.
2002: Katya Chobotova; Mary-Elizabeth Muchmore; Janet Carver; Hyung-J Yoo; Sanjiv Manek; William J Gullick; David H Barlow; Helen J Mardon
The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-alpha.
The Journal of clinical endocrinology and metabolism 2002;87(12):5769-77.
2002: Katya Chobotova; isabella spyropoulou; Janet Carver; Sanjiv Manek; John Heath; William J Gullick; David H Barlow; Ian L Sargent; Helen J Mardon
Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst.
Mechanisms of development 2002;119(2):137-44.
2002: Antonio D'Antonio; Simona Losito; Sandro Pignata; Michele Grassi; Francesco Perrone; Antonella De Luca; Rosa Tambaro; Caterina Bianco; William J Gullick; Gibbes R Johnson; Vincenzo Rosario Iaffaioli; David S Salomon; Nicola Normanno
Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas.
International journal of oncology 2002;21(5):941-8.
2002: Terrance G Johns; Elisabeth Stockert; Gerd Ritter; Achim A Jungbluth; H-J Su Huang; Webster K Cavenee; Fiona E Smyth; Cathrine M Hall; Nadine Watson; Edouard C Nice; William J Gullick; Lloyd J Old; Antony W Burgess; Andrew M Scott
Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene.
International journal of cancer. Journal international du cancer 2002;98(3):398-408.
2002: William J Gullick
A new model for ductal carcinoma in situ suggests strategies for treatment.
Breast cancer research : BCR 2002;4(5):176-8.
2001: William J Gullick
The Type 1 growth factor receptors and their ligands considered as a complex system.
Endocrine-related cancer 2001;8(2):75-82.
2001: K Clarke; Kath Smith; William J Gullick; Adrian L Harris
Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway.
British journal of cancer 2001;84(10):1322-9.
2001: R Srinivasan; K E Leverton; H Sheldon; HC Hurst; C Sarraf; William J Gullick
Intracellular expression of the truncated extracellular domain of c-erbB-3/HER3.
Cellular signalling 2001;13(5):321-30.
2001: L M Gilmour; Kenneth G Macleod; A McCaig; William J Gullick; John F Smyth; Simon P Langdon
Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer.
Cancer research 2001;61(5):2169-76.
2001: William J Gullick
Update on HER-2 as a target for cancer therapy: alternative strategies for targeting the epidermal growth factor system in cancer.
Breast cancer research : BCR 2001;3(6):390-4.
2000: R Srinivasan; Cheryl E Gillett; D M Barnes; William J Gullick
Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers.
Cancer research 2000;60(6):1483-7.
1999: R Srinivasan; E Benton; F McCormick; H Thomas; William J Gullick
Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2877-83.
1999: H Gillham; Matthew Golding; R Pepperkok; William J Gullick
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
The Journal of cell biology 1999;146(4):869-80.
1999: William J Gullick; C Lewanski
Coronary angioplasty: an end to early closing?
Gene therapy 1999;6(6):954-5.
1998: R Srinivasan; R Poulsom; HC Hurst; William J Gullick
Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
The Journal of pathology 1998;185(3):236-45.
1998: William J Gullick; R Srinivasan
The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer.
Breast cancer research and treatment 1998;52(1-3):43-53.
1998: William J Gullick
Type I growth factor receptors: current status and future work.
Biochemical Society symposium 1998;63():193-8.
1997: H Y Leung; J Weston; William J Gullick; G Williams
A potential autocrine loop between heregulin-alpha and erbB-3 receptor in human prostatic adenocarcinoma.
British journal of urology 1997;79(2):212-6.
1996: THANGARAJAN RAJKUMAR; G W Stamp; C M Hughes; William J Gullick
c-erbB3 protein expression in ovarian cancer.
Clinical molecular pathology 1996;49(4):M199-202.
1996: William J Gullick
The c-erbB3/HER3 receptor in human cancer.
Cancer surveys 1996;27():339-49.
1995: D Hills; G Rowlinson-Busza; William J Gullick
Specific targeting of a mutant, activated FGF receptor found in glioblastoma using a monoclonal antibody.
International journal of cancer. Journal international du cancer 1995;63(4):537-43.
1994: H Y Leung; William J Gullick; Nick Lemoine
Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer.
International journal of cancer. Journal international du cancer 1994;59(5):667-75.
1994: THANGARAJAN RAJKUMAR; William J Gullick
A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines.
British journal of cancer 1994;70(3):459-65.
1994: S A Prigent; William J Gullick
Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera.
The EMBO journal 1994;13(12):2831-41.
1994: N L Tuzi; William J Gullick
eph, the largest known family of putative growth factor receptors.
British journal of cancer 1994;69(3):417-21.
1994: THANGARAJAN RAJKUMAR; William J Gullick
The type I growth factor receptors in human breast cancer.
Breast cancer research and treatment 1994;29(1):3-9.
1994: William J Gullick; A H Handyside
Pre-implantation diagnosis of inherited predisposition to cancer.
European journal of cancer (Oxford, England : 1990) 1994;30A(13):2030-2.
1993: F J Lofts; Helen C Hurst; M J Sternberg; William J Gullick
Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo.
Oncogene 1993;8(10):2813-20.
1993: THANGARAJAN RAJKUMAR; C S Gooden; Nick Lemoine; William J Gullick; C S Goden
Expression of the c-erbB-3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1.
The Journal of pathology 1993;170(3):271-8.
1992: Nick Lemoine; D M Barnes; Donal Hollywood; C M Hughes; P Smith; E Dublin; S A Prigent; William J Gullick; Helen C Hurst
Expression of the ERBB3 gene product in breast cancer.
British journal of cancer 1992;66(6):1116-21.
1992: Nick Lemoine; M Lobresco; H Leung; C Barton; C M Hughes; S A Prigent; William J Gullick; G Klöppel
The erbB-3 gene in human pancreatic cancer.
The Journal of pathology 1992;168(3):269-73.
1992: S A Prigent; Nick Lemoine; C M Hughes; G D Plowman; Clare Selden; William J Gullick
Expression of the c-erbB-3 protein in normal human adult and fetal tissues.
Oncogene 1992;7(7):1273-8.
1992: Nick Lemoine; C M Hughes; C M Barton; Richard Poulsom; R E Jeffery; G Klöppel; P A Hall; William J Gullick
The epidermal growth factor receptor in human pancreatic cancer.
The Journal of pathology 1992;166(1):7-12.
1992: William J Gullick; A C Bottomley; F J Lofts; D G Doak; D Mulvey; R Newman; M J Crumpton; M J Sternberg; Iain D Campbell
Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein.
The EMBO journal 1992;11(1):43-8.
1991: Nick Lemoine; C M Hughes; William J Gullick; C L Brown; D Wynford-Thomas
Abnormalities of the EGF receptor system in human thyroid neoplasia.
International journal of cancer. Journal international du cancer 1991;49(4):558-61.
1991: William J Gullick; C M Hughes; K Mellon; D E Neal; Nick Lemoine
Immunohistochemical detection of the epidermal growth factor receptor in paraffin-embedded human tissues.
The Journal of pathology 1991;164(4):285-9.
1991: Nick Lemoine; S Jain; F Silvestre; C Lopes; C M Hughes; E McLelland; William J Gullick; M I Filipe
Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer.
British journal of cancer 1991;64(1):79-83.
1991: G Ong; K Sikora; William J Gullick
Inactivation of the retinoblastoma gene does not lead to loss of TGF-beta receptors or response to TGF-beta in breast cancer cell lines.
Oncogene 1991;6(5):761-3.
1991: William J Gullick; S B Love; C Wright; D M Barnes; B Gusterson; Adrian L Harris; Douglas Altman
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
British journal of cancer 1991;63(3):434-8.
1991: C M Barton; P A Hall; C M Hughes; William J Gullick; Nick Lemoine
Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer.
The Journal of pathology 1991;163(2):111-6.
1991: N L Tuzi; D J Venter; S Kumar; S L Staddon; Nick Lemoine; William J Gullick
Expression of growth factor receptors in human brain tumours.
British journal of cancer 1991;63(2):227-33.
1991: A Qayum; William J Gullick; J Waxman
Gonadotrophin-releasing hormone: physiological significance and relevance to cancer.
Progress in growth factor research 1991;3(2):115-30.
1990: A Qayum; William J Gullick; K Mellon; T Krausz; D Neal; K Sikora; J Waxman
The partial purification and characterization of GnRH-like activity from prostatic biopsy specimens and prostatic cancer cell lines.
The Journal of steroid biochemistry and molecular biology 1990;37(6):899-902.
1990: J S Haldane; V Hird; C M Hughes; William J Gullick
c-erbB-2 oncogene expression in ovarian cancer.
The Journal of pathology 1990;162(3):231-7.
1990: P A Hall; C M Hughes; S L Staddon; P I Richman; William J Gullick; Nick Lemoine
The c-erb B-2 proto-oncogene in human pancreatic cancer.
The Journal of pathology 1990;161(3):195-200.
1990: William J Gullick
New developments in the molecular biology of breast cancer.
European journal of cancer (Oxford, England : 1990) 1990;26(4):509-10.
1990: G Ong; William J Gullick; K Sikora
Oncoprotein stability after tumour resection.
British journal of cancer 1990;61(4):538-42.
1990: Nick Lemoine; S Staddon; C Dickson; D M Barnes; William J Gullick
Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.
Oncogene 1990;5(2):237-9.
1990: Nick Lemoine; F S Wyllie; Johan R Lillehaug; S L Staddon; C M Hughes; Rein Aasland; J Shaw; J E Varhaug; C L Brown; William J Gullick
Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia.
European journal of cancer (Oxford, England : 1990) 1990;26(7):777-9.
1990: William J Gullick
Growth factors and oncogenes in breast cancer.
Progress in growth factor research 1990;2(1):1-13.
1989: William J Gullick
Expression of the c-erbB-2 proto-oncogene protein in human breast cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1989;113():51-6.
1988: N L Tuzi; D J Venter; J A Reidlinger; C J Dean; William J Gullick
Production and characterization of monoclonal antibodies to the c-erbB-2 proto-oncogene protein using a synthetic peptide immunogen.
Biochemical Society transactions 1988;16(5):675-7.