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Mark Gumbleton

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Ian P Matthews; Iain McDonald; Christopher J Morris; Ghaith Aljayyoussi; Clive J Gregory; Bastiaan Hoogendoorn; Mark Gumbleton
Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat.
Mathew W Smith; Ghaith Al-Jayyoussi; Mark Gumbleton
Peptide sequences mediating tropism to intact blood-brain barrier: an in vivo biodistribution study using phage display.
Ayca Yildiz; Yildiz Ozsoy; Elinor John; Ahmet Araman; James C Birchall; Kenneth J Broadley; Mark Gumbleton
Inhaled extended-release microparticles of heparin elicit improved pulmonary pharmacodynamics against antigen-mediated airway hyper-reactivity and inflammation.

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All Publications

2013: Ian P Matthews; Iain McDonald; Christopher J Morris; Ghaith Aljayyoussi; Clive J Gregory; Bastiaan Hoogendoorn; Mark Gumbleton
Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat.
Environmental toxicology and pharmacology 2013;35(3):461-4.
2012: Mathew W Smith; Ghaith Al-Jayyoussi; Mark Gumbleton
Peptide sequences mediating tropism to intact blood-brain barrier: an in vivo biodistribution study using phage display.
Peptides 2012;38(1):172-80.
2012: Ayca Yildiz; Yildiz Ozsoy; Elinor John; Ahmet Araman; James C Birchall; Kenneth J Broadley; Mark Gumbleton
Inhaled extended-release microparticles of heparin elicit improved pulmonary pharmacodynamics against antigen-mediated airway hyper-reactivity and inflammation.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(2):456-63.
2012: Christopher J Morris; David Ulaeto; Konrad Beck; Graeme C Clark; Marc A Fox; Mark Gumbleton
Pegylation of antimicrobial peptides maintains the active peptide conformation, model membrane interactions, and antimicrobial activity while improving lung tissue biocompatibility following airway delivery.
Antimicrobial agents and chemotherapy 2012;56(6):3298-308.
2012: Ghaith Aljayyoussi; Peter Griffiths; Muthanna Abdulkarim; Mark Gumbleton
Pharmaceutical nanoparticles and the mucin biopolymer barrier.
BioImpacts : BI 2012;2(4):173-4.
2011: Christopher J Morris; Mathew W Smith; Peter C Griffiths; Neil B McKeown; Mark Gumbleton
Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide.
Journal of controlled release : official journal of the Controlled Release Society 2011;151(1):83-94.
2011: Ben Forbes; Bahman Asgharian; Lea Ann Dailey; Douglas Ferguson; Per Gerde; Mark Gumbleton; Lena Gustavsson; Colin Hardy; David Hassall; Rhys Jones; Ruth Lock; Janet Maas; Tim McGovern; Gary R Pitcairn; Graham Somers; Ron K Wolff
Challenges in inhaled product development and opportunities for open innovation.
Advanced drug delivery reviews 2011;63(1-2):69-87.
2011: Mark Gumbleton; Ghaith Al-Jayyoussi; Adam Crandon-Lewis; Danielle Francombe; Katharina Kreitmeyr; Chris J Morris; Mathew W Smith
Spatial expression and functionality of drug transporters in the intact lung: objectives for further research.
Advanced drug delivery reviews 2011;63(1-2):110-8.
2010: John S Patton; Joseph D Brain; Lee A Davies; Jennifer Fiegel; Mark Gumbleton; Kwang-Jin Kim; Masahiro Sakagami; Rita Vanbever; Carsten Ehrhardt
The particle has landed--characterizing the fate of inhaled pharmaceuticals.
Journal of aerosol medicine and pulmonary drug delivery 2010;23 Suppl 2():S71-87.
2010: Nicholas B P Thomas; Iain R Hutcheson; Lee Campbell; Julia Gee; Kathryn M Taylor; Robert I Nicholson; Mark Gumbleton
Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance.
Breast cancer research and treatment 2010;119(3):575-91.
2010: Peter C Griffiths; Paola Occhipinti; Christopher Morris; Richard K Heenan; Stephen Michael King; Mark Gumbleton
PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin.
Biomacromolecules 2010;11(1):120-5.
2010: Jaleh Barar; Mark Gumbleton; Masoud Asadi; Yadollah Omidi
Barrier functionality and transport machineries of human ECV304 cells.
Medical science monitor : international medical journal of experimental and clinical research 2010;16(1):BR52-60.
2009: Lee Campbell; Rosa Nuttall; David Griffiths; Mark Gumbleton
Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma.
Cancer 2009;115(15):3457-67.
2009: Sibylle Endter; Danielle Francombe; Carsten Ehrhardt; Mark Gumbleton
RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models.
The Journal of pharmacy and pharmacology 2009;61(5):583-91.
2008: Mark Gumbleton
2008 Editors' Collection.
Advanced drug delivery reviews 2008;60(15):1569.
2008: Yadollah Omidi; Jaleh Barar; Somaieh Ahmadian; Hamid Reza Heidari; Mark Gumbleton
Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells.
Cell biochemistry and function 2008;26(3):381-91.
2008: Lee Campbell; Bharat Jasani; K Edwards; Mark Gumbleton; D F R Griffiths
Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma.
British journal of cancer 2008;98(5):931-40.
2007: Jaleh Barar; Lee Campbell; Andrew J Hollins; Nicholas P B Thomas; Mathew W Smith; Christopher J Morris; Mark Gumbleton
Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures.
Biochemical and biophysical research communications 2007;359(2):360-6.
2007: Mathew W Smith; Jonathan W Smith; Charlotte Harris; Andrea Brancale; Christopher J Allender; Mark Gumbleton
Phage display identification of functional binding peptides against 4-acetamidophenol (Paracetamol): an exemplified approach to target low molecular weight organic molecules.
Biochemical and biophysical research communications 2007;358(1):285-91.
2007: Mathew Smith; Yadollah Omidi; Mark Gumbleton
Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting.
Journal of drug targeting 2007;15(4):253-68.
2007: Elizabeth Collins; James Birchall; Julie L Williams; Mark Gumbleton
Nuclear localisation and pDNA condensation in non-viral gene delivery.
The journal of gene medicine 2007;9(4):265-74.
2007: Sibylle Endter; Ulrich Becker; Nicole Daum; Hanno Huwer; Claus-Michael Lehr; Mark Gumbleton; Carsten Ehrhardt
P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers.
Cell and tissue research 2007;328(1):77-84.
2006: Mark Gumbleton; Glyn Taylor
Challenges and innovations in effective pulmonary systemic and macromolecular drug delivery.
Advanced drug delivery reviews 2006;58(9-10):993-5.
2006: Mathew W Smith; Mark Gumbleton
Endocytosis at the blood-brain barrier: from basic understanding to drug delivery strategies.
Journal of drug targeting 2006;14(4):191-214.
2006: Masahiro Sakagami; Yadollah Omidi; Lee Campbell; Lana E Kandalaft; Christopher J Morris; Jaleh Barar; Mark Gumbleton
Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung.
Pharmaceutical research 2006;23(2):270-9.
2005: Mark Gumbleton; David J Stephens
Coming out of the dark: the evolving role of fluorescence imaging in drug delivery research.
Advanced drug delivery reviews 2005;57(1):5-15.
2004: Christopher J Von Ruhland; Lee Campbell; Mark Gumbleton; Bharat Jasani; Geoffrey R Newman
Immunolocalization of caveolin-1 in rat and human mesothelium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(11):1415-25.
2004: Abedel-Nasser G Abulrob; Marc T E Suller; Mark Gumbleton; Claire Simons; A Denver Russell
Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains.
Phytochemistry 2004;65(22):3021-7.
2004: Dario Siccardi; Mark Gumbleton; Yadollah Omidi; Christopher McGuigan
Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;22(1):25-31.
2003: Dario Siccardi; Lana E Kandalaft; Mark Gumbleton; Christopher McGuigan
Stereoselective and concentration-dependent polarized epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: an in vitro study in Caco-2 and Madin-Darby canine kidney cell monolayers.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1112-9.
2003: Lee Campbell; Mark Gumbleton; D F R Griffiths
Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma.
British journal of cancer 2003;89(10):1909-13.
2003: Arwyn T Jones; Mark Gumbleton; Ruth Duncan
Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems.
Advanced drug delivery reviews 2003;55(11):1353-7.
2003: Yadollah Omidi; Lee Campbell; Jaleh Barar; David Connell; Saeed Akhtar; Mark Gumbleton
Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies.
Brain research 2003;990(1-2):95-112.
2003: Mark Gumbleton; Andrew J Hollins; Yadollah Omidi; Lee Campbell; Glyn Taylor
Targeting caveolae for vesicular drug transport.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):139-51.
2003: Lee Campbell; Abedel-Nasser G Abulrob; Lana E Kandalaft; Steven Plummer; Andrew J Hollins; Alan Gibbs; Mark Gumbleton
Constitutive expression of p-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures.
The Journal of pharmacology and experimental therapeutics 2003;304(1):441-52.
2003: Sabine Fuchs; Andrew J Hollins; Michael Laue; Ulrich F Schaefer; Klaus Roemer; Mark Gumbleton; Claus-Michael Lehr
Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C.
Cell and tissue research 2003;311(1):31-45.
2002: Lee Campbell; P Laidler; R E B Watson; B Kirby; Christopher E M Griffiths; Mark Gumbleton
Downregulation and altered spatial pattern of caveolin-1 in chronic plaque psoriasis.
The British journal of dermatology 2002;147(4):701-9.
2002: Andrew J Hollins; Lee Campbell; Mark Gumbleton; Darrell J R Evans
Caveolin expression during chondrogenesis in the avian limb.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;225(2):205-11.
2002: BG Jones; Paul A Dickinson; Mark Gumbleton; Ian W Kellaway
Lung surfactant phospholipids inhibit the uptake of respirable microspheres by the alveolar macrophage NR8383.
The Journal of pharmacy and pharmacology 2002;54(8):1065-72.
2002: BG Jones; Paul A Dickinson; Mark Gumbleton; Ian W Kellaway
The inhibition of phagocytosis of respirable microspheres by alveolar and peritoneal macrophages.
International journal of pharmaceutics 2002;236(1-2):65-79.
2002: E Ramsay; Mark Gumbleton
Polylysine and polyornithine gene transfer complexes: a study of complex stability and cellular uptake as a basis for their differential in-vitro transfection efficiency.
Journal of drug targeting 2002;10(1):1-9.
2001: Mark Gumbleton; K L Audus
Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier.
Journal of pharmaceutical sciences 2001;90(11):1681-98.
2001: Lee Campbell; Mark Gumbleton; K Ritchie
Caveolae and the caveolins in human disease.
Advanced drug delivery reviews 2001;49(3):325-35.
2001: Mark Gumbleton
Caveolae as potential macromolecule trafficking compartments within alveolar epithelium.
Advanced drug delivery reviews 2001;49(3):281-300.
2001: Mark Gumbleton
Caveolae-mediated membrane transport.
Advanced drug delivery reviews 2001;49(3):217-21.
2001: James Birchall; C A Waterworth; C Luscombe; D A Parkins; Mark Gumbleton
Statistical modelling of the formulation variables in non-viral gene delivery systems.
Journal of drug targeting 2001;9(3):169-84.
2000: E Ramsay; Jonathan Hadgraft; James Birchall; Mark Gumbleton
Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro.
International journal of pharmaceutics 2000;210(1-2):97-107.
2000: Lee Campbell; Mark Gumbleton
Aberrant caveolin-1 expression in psoriasis: a signalling hypothesis.
IUBMB life 2000;50(6):361-4.
2000: Mark Gumbleton; A G Abulrob; Lee Campbell
Caveolae: an alternative membrane transport compartment.
Pharmaceutical research 2000;17(9):1035-48.
2000: James Birchall; C Marichal; L Campbell; A Alwan; Jonathan Hadgraft; Mark Gumbleton
Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome-plasmid DNA complexes.
International journal of pharmaceutics 2000;197(1-2):233-8.
2000: James Birchall; Ian W Kellaway; Mark Gumbleton
Physical stability and in-vitro gene expression efficiency of nebulised lipid-peptide-DNA complexes.
International journal of pharmaceutics 2000;197(1-2):221-31.
2000: BG Jones; Mark Gumbleton; Ian W Kellaway; Paul A Dickinson
Microcalorimetry does not predict the cellular phagocytosis of latex microspheres.
International journal of pharmaceutics 2000;195(1-2):17-23.
2000: Abedel-Nasser G Abulrob; M Mason; Richard Bryce; Mark Gumbleton
The effect of fatty acids and analogues upon intracellular levels of doxorubicin in cells displaying P-glycoprotein mediated multidrug resistance.
Journal of drug targeting 2000;8(4):247-56.
1999: Lee Campbell; Andrew J Hollins; A Al-Eid; Geoffrey R Newman; Christopher J Von Ruhland; Mark Gumbleton
Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures.
Biochemical and biophysical research communications 1999;262(3):744-51.
1999: A G Abulrob; Mark Gumbleton
Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein.
Biochemical and biophysical research communications 1999;262(1):121-6.
1999: Geoffrey R Newman; Lee Campbell; Christopher J Von Ruhland; Bharat Jasani; Mark Gumbleton
Caveolin and its cellular and subcellular immunolocalisation in lung alveolar epithelium: implications for alveolar epithelial type I cell function.
Cell and tissue research 1999;295(1):111-20.
1998: Christopher McGuigan; P W Sutton; D Cahard; K Turner; G O'Leary; Y Wang; Mark Gumbleton; Erik De Clercq; Jan Balzarini
Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
Antiviral chemistry & chemotherapy 1998;9(6):473-9.