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Daniela Gündisch

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Edwin G Pérez; Bruce K Cassels; Christoph Eibl; Daniela Gündisch
Synthesis and evaluation of N(1)-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands.
Jan Bucerius; Zahi A Fayad; Daniela Gündisch; Venkatesh Mani; Christoph Manka; Felix M Mottaghy; James Rudd; Joern Schmaljohann; Ullrich Wüllner; Rolf Bippus; Hans-Jürgen Biersack
Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo.
Daniela Gündisch; Christoph Eibl
Nicotinic acetylcholine receptor ligands, a patent review (2006-2011).

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All Publications

2012: Edwin G Pérez; Bruce K Cassels; Christoph Eibl; Daniela Gündisch
Synthesis and evaluation of N(1)-alkylindole-3-ylalkylammonium compounds as nicotinic acetylcholine receptor ligands.
Bioorganic & medicinal chemistry 2012;20(12):3719-27.
2012: Jan Bucerius; Zahi A Fayad; Daniela Gündisch; Venkatesh Mani; Christoph Manka; Felix M Mottaghy; James Rudd; Joern Schmaljohann; Ullrich Wüllner; Rolf Bippus; Hans-Jürgen Biersack
Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo.
JACC. Cardiovascular imaging 2012;5(5):528-36.
2011: Daniela Gündisch; Christoph Eibl
Nicotinic acetylcholine receptor ligands, a patent review (2006-2011).
Expert opinion on therapeutic patents 2011;21(12):1867-96.
2011: Paul W Elsinghorst; Daniela Gündisch; Wolfgang Härtig; Klaus Mohr; Christian Tränkle; Michael Gütschow
A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins.
Current topics in medicinal chemistry 2011;11(22):2731-48.
2011: Yann S Mineur; Yan Rao; Ramiro Salas; Alfonso Abizaid; Mariella De Biasi; Sabrina Diano; Ralph J DiLeone; Xiao-Bing Gao; Daniela Gündisch; Tamas L Horvath; Marina R Picciotto
Nicotine decreases food intake through activation of POMC neurons.
Science (New York, N.Y.) 2011;332(6035):1330-2.
2009: Yann S Mineur; Christoph Eibl; Grace Young; Christopher Kochevar; Roger L Papke; Daniela Gündisch; Marina R Picciotto
Cytisine-based nicotinic partial agonists as novel antidepressant compounds.
The Journal of pharmacology and experimental therapeutics 2009;329(1):377-86.
2008: Ullrich Wüllner; Daniela Gündisch; Hans Herzog; Martina Minnerop; Alexius Y Joe; Marc Warnecke; Frank Jessen; Christian Schütz; Michael Reinhardt; Wolfgang Eschner; Thomas Klockgether; Joern Schmaljohann
Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain.
Neuroscience letters 2008;430(1):34-7.
2007: Marianne Patt; Christoph Solbach; Ullrich Wüllner; A Blocher; Anke Stahlschmidt; Daniela Gündisch; Karl-Artur Kovar; Hans-Jürgen Machulla
Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007;10(2):312s-320s.
2006: Joern Schmaljohann; Daniela Gündisch; Martina Minnerop; Jan Bucerius; Alexius Y Joe; Michael Reinhardt; Stefan Guhlke; Hans-Jürgen Biersack; Ullrich Wüllner
In vitro evaluation of nicotinic acetylcholine receptors with 2-[18F]F-A85380 in Parkinson's disease.
Nuclear medicine and biology 2006;33(3):305-9.
2006: Darius P Zlotos; Christian Tränkle; Aliaa Abdelrahman; Daniela Gündisch; Krzysztof Radacki; Holger Braunschweig; Klaus Mohr
6H,13H-Pyrazino[1,2-a;4,5-a']diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors.
Bioorganic & medicinal chemistry letters 2006;16(6):1481-5.
2006: Jan Bucerius; Alexius Y Joe; Joern Schmaljohann; Daniela Gündisch; Martina Minnerop; Hans-Jürgen Biersack; Ullrich Wüllner; Michael Reinhardt
Feasibility of 2-deoxy-2-[18F]fluoro-D-glucose- A85380-PET for imaging of human cardiac nicotinic acetylcholine receptors in vivo.
Clinical research in cardiology : official journal of the German Cardiac Society 2006;95(2):105-9.
2005: Joern Schmaljohann; Daniela Gündisch; Martina Minnerop; Alexius Y Joe; Jan Bucerius; C Dittmar; F Jessen; Stefan Guhlke; Ullrich Wüllner
A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2005;63(4):433-5.
2005: Richard W Fitch; Yumika Kaneko; Paul Klaperski; John W Daly; Gunther Seitz; Daniela Gündisch
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry letters 2005;15(4):1221-4.
2005: Enzo Lain; Botond Penke; André Delacourte; Daniela Gündisch; Hannsjörg Schröder; Brigitte Witter
Effects of Abeta1-42 fibrils and of the tetrapeptide Pr-IIGL on the phosphorylation state of the tau-protein and on the alpha7 nicotinic acetylcholine receptor in vitro.
The European journal of neuroscience 2005;21(4):879-88.
2005: Daniela Gündisch; Andrei O KoreN; Andrew G Horti; Olga A Pavlova; Alane S Kimes; Alexey G Mukhin; Edythe D London
In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors.
Synapse (New York, N.Y.) 2005;55(2):89-97.
2005: Daniela Gündisch
[Nuclides and tracers--mechanisms and application. Radiodiagnosis for peripheral organ diseases].
Pharmazie in unserer Zeit 2005;34(6):484-9.
2004: Darius P Zlotos; Daniela Gündisch; S Ferraro; Maria Cristina Tilotta; Nikolaus Stiefl; Knut Baumann
Bisquaternary caracurine V and iso-caracurine V salts as ligands for the muscle type of nicotinic acetylcholine receptors: SAR and QSAR studies.
Bioorganic & medicinal chemistry 2004;12(23):6277-85.
2004: Joern Schmaljohann; Martina Minnerop; P Karwath; Daniela Gündisch; Peter Falkai; Stefan Guhlke; Ullrich Wüllner
Imaging of central nAChReceptors with 2-[18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2004;61(6):1235-40.
2004: Lars Peters; Anthony D Wright; Stefan Kehraus; Daniela Gündisch; Maria Cristina Tilotta; Gabriele M König
Prenylated indole alkaloids from Flustra foliacea with subtype specific binding on NAChRs.
Planta medica 2004;70(10):883-6.
2004: Daniela Gündisch; Matthias Andrä; Lenka Munoz; Maria Cristina Tilotta
Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry 2004;12(18):4953-62.
2004: S Seifert; A Stehl; Maria Cristina Tilotta; Daniela Gündisch; Gunther Seitz
Novel enantiopure ferrugininoids active as nicotinic agents: synthesis and radioligand binding studies.
Die Pharmazie 2004;59(6):427-34.
2003: Holger Gohlke; Simone Schwarz; Daniela Gündisch; Maria Cristina Tilotta; Alexander Weber; Thomas Wegge; Gunther Seitz
3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor.
Journal of medicinal chemistry 2003;46(11):2031-48.
2003: S Seifert; Daniela Gündisch; Maria Cristina Tilotta; Gunther Seitz
Improved synthesis and in vitro evaluation of quinuclidin-2-ene based ligands for the nicotinic acetylcholine receptor.
Die Pharmazie 2003;58(5):353-4.
2003: Simone Schwarz; T Kämpchen; Maria Cristina Tilotta; Daniela Gündisch; Gunther Seitz
Synthesis and nicotinic binding studies on enantiopure pinnamine variants with an 8-azabicyclo[3.2.1]octane moiety.
Die Pharmazie 2003;58(5):295-9.
2002: Holger Gohlke; Daniela Gündisch; Simone Schwarz; Gunther Seitz; Maria Cristina Tilotta; Thomas Wegge
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
Journal of medicinal chemistry 2002;45(5):1064-72.
2002: Daniela Gündisch; Thomas Kämpchen; Simone Schwarz; Gunther Seitz; Johanna Siegl; Thomas Wegge
Syntheses and evaluation of pyridazine and pyrimidine containing bioisosteres of (+/-)-pyrido[3.4-b]homotropane and pyrido-[3.4-b]tropane as novel nAChR ligands.
Bioorganic & medicinal chemistry 2002;10(1):1-9.
2001: Daniela Gündisch; K Harms; Simone Schwarz; Gunther Seitz; MT Stubbs; Thomas Wegge
Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry 2001;9(10):2683-91.
2001: P Imming; P Klaperski; MT Stubbs; Gunther Seitz; Daniela Gündisch
Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands.
European journal of medicinal chemistry 2001;36(4):375-88.
2000: A Harms; Daniela Gündisch; C E Müller; Karl-Artur Kovar
Development of a 5-hydroxytryptamine(2A) receptor binding assay for high throughput screening using 96-well microfilter plates.
Journal of biomolecular screening 2000;5(4):269-78.
2000: Daniela Gündisch
Nicotinic acetylcholine receptors and imaging.
Current pharmaceutical design 2000;6(11):1143-57.
2000: Andrew G Horti; Svetlana I Chefer; Alexey G Mukhin; Andrei O KoreN; Daniela Gündisch; Jonathan M Links; Varughese Kurian; Robert F Dannals; Edythe D London
6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors.
Life sciences 2000;67(4):463-9.
2000: Alexey G Mukhin; Daniela Gündisch; Andrew G Horti; Andrei O KoreN; Gilles Tamagnan; Alane S Kimes; J Chambers; D Bruce Vaupel; Sarah L King; Marina R Picciotto; Robert B Innis; Edythe D London
5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors.
Molecular pharmacology 2000;57(3):642-9.
1999: Svetlana I Chefer; Andrew G Horti; Andrei O KoreN; Daniela Gündisch; Jonathan M Links; Varughese Kurian; Robert F Dannals; Alexey G Mukhin; Edythe D London
2-[18F]F-A-85380: a PET radioligand for alpha4beta2 nicotinic acetylcholine receptors.
Neuroreport 1999;10(13):2715-21.
1998: Andrei O KoreN; Andrew G Horti; Alexey G Mukhin; Daniela Gündisch; Alane S Kimes; Robert F Dannals; Edythe D London
2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.
Journal of medicinal chemistry 1998;41(19):3690-8.