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Grace Guo

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Yan Zhu; Lauren M Aleksunes; Yafeng Dong; Bo Kong; Fei Li; Guodong Li; Jason R Richardson; Helen H Zhou; Grace L Guo
Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver.
Prachi Borude; Genea Edwards; Grace L Guo; Bo Kong; Feng Li; Xiaochao Ma; Chad Walesky; Udayan Apte
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice.
Bo Kong; Li Wang; Youcai Zhang; John Y L Chiang; Curtis D Klaassen; Grace L Guo
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.

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All Publications

2013: Yan Zhu; Lauren M Aleksunes; Yafeng Dong; Bo Kong; Fei Li; Guodong Li; Jason R Richardson; Helen H Zhou; Grace L Guo
Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver.
Toxicology and applied pharmacology 2013;266(2):260-6.
2012: Prachi Borude; Genea Edwards; Grace L Guo; Bo Kong; Feng Li; Xiaochao Ma; Chad Walesky; Udayan Apte
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice.
Hepatology (Baltimore, Md.) 2012;56(6):2344-52.
2012: Bo Kong; Li Wang; Youcai Zhang; John Y L Chiang; Curtis D Klaassen; Grace L Guo
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.
Hepatology (Baltimore, Md.) 2012;56(3):1034-43.
2012: Bo Kong; Xiaochao Ma; Meghan Patni; Scott Weir; Lauren M Aleksunes; Melinda Broward; Qi Chen; Iván Csanaky; Hartmut Jaeschke; Curtis D Klaassen; Grace L Guo
Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.
Toxicology and applied pharmacology 2012;261(2):189-95.
2012: Julia Yue Cui; Zidong Donna Fu; Grace L Guo; Ying Guo; Hong Lu; Yuji Tanaka; Xiao-bo Zhong; Lauren M Aleksunes; Curtis D Klaassen
Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(9):G979-96.
2012: Guodong Li; Wenwei Lin; Barbara N Timmermann; Juan J Araya; Taosheng Chen; Grace L Guo
A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.
Toxicology and applied pharmacology 2012;258(2):268-74.
2012: Jessica A Williams; Wen Xie; Le Zhan; Wen-Xing Ding; Yuka Inaba; Bo Kong; Guodong Li; Ann M Thomas; Grace L Guo
Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.
PloS one 2012;7(8):e43961.
2012: Guodong Li; Jie Liu; Ann M Thomas; Jessica A Williams; Wen Xie; Yuka Inaba; Bo Kong; Grace L Guo
Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.
PloS one 2012;7(4):e35895.
2011: Erik Pacyniak; Bruno Hagenbuch; Curtis D Klaassen; Lois Lehman-McKeeman; Grace L Guo
Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice.
Toxicology and applied pharmacology 2011;257(1):23-31.
2011: Karen M Kassel; Guodong Li; Grace L Guo; Nigel Mackman; A Phillip Owens; Cheryl E Rockwell; Bradley P Sullivan; Ossama Tawfik; Ruipeng Wang; James P Luyendyk
Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.
The American journal of pathology 2011;179(5):2278-89.
2011: James P Luyendyk; Grace L Guo
Steatosis DeLIVERs high-sensitivity C-reactive protein.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(8):1714-5.
2011: Guodong Li; Grace L Guo
Role of Class II nuclear receptors in liver carcinogenesis.
Anti-cancer agents in medicinal chemistry 2011;11(6):529-42.
2011: Andy Wolfe; Genea Edwards; Grace L Guo; Reshma Jaseja; Ann Thomas; Udayan Apte
Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice.
The Journal of pharmacology and experimental therapeutics 2011;338(1):12-21.
2011: Yan Zhu; Fei Li; Grace L Guo
Tissue-specific function of farnesoid X receptor in liver and intestine.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(4):259-65.
2011: James P Luyendyk; Karen M Kassel; Katryn Allen; Grace L Guo; Guodong Li; Glenn H Cantor; Bryan L Copple
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.
The American journal of pathology 2011;178(3):1117-25.
2011: Bo Kong; Grace L Guo
Enhanced in vitro refolding of fibroblast growth factor 15 with the assistance of SUMO fusion partner.
PloS one 2011;6(5):e20307.
2011: Yu-Kun Jennifer Zhang; Grace L Guo; Curtis D Klaassen
Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters.
PloS one 2011;6(2):e16683.
2010: Laiyou Wang; Feng Li; Jie Lu; Guodong Li; Dan Li; Xiao-bo Zhong; Grace L Guo; Xiaochao Ma
The Chinese herbal medicine Sophora flavescens activates pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(12):2226-31.
2010: Karen M Kassel; Grace L Guo; Ossama Tawfik; James P Luyendyk
Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet.
Laboratory investigation; a journal of technical methods and pathology 2010;90(12):1794-804.
2010: Guodong Li; Ann M Thomas; Steven N Hart; Xiaobo Zhong; Dequan Wu; Grace L Guo
Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner.
Molecular endocrinology (Baltimore, Md.) 2010;24(7):1404-12.
2010: Kristian W Fried; Grace L Guo; Noriko Esterly; Bo Kong; Karl K Rozman
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reverses hyperglycemia in a type II diabetes mellitus rat model by a mechanism unrelated to PPAR gamma.
Drug and chemical toxicology 2010;33(3):261-8.
2010: Erik Pacyniak; Megan Roth; Bruno Hagenbuch; Grace L Guo
Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(2):344-53.
2010: Feng Li; Laiyou Wang; Grace L Guo; Xiaochao Ma
Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(5):871-8.
2010: Ann M Thomas; Steven N Hart; Bo Kong; Jianwen Fang; Xiao-Bo Zhong; Grace L Guo
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.
Hepatology (Baltimore, Md.) 2010;51(4):1410-9.
2010: Benjamin P Weaver; Yuxia Zhang; Stephen Hiscox; Grace L Guo; Udayan Apte; Kathryn M Taylor; Christian T Sheline; li wang; Glen K Andrews
Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.
PloS one 2010;5(10):.
2010: James P Luyendyk; Bradley P Sullivan; Grace L Guo; Ruipeng Wang
Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice.
The American journal of pathology 2010;176(1):177-86.
2009: Rengasamy R M Maran; Ann Thomas; Megan Roth; Zhonghua Sheng; Noriko Esterly; David M Pinson; Xin Gao; Yawei Zhang; Vadivel Ganapathy; Frank J Gonzalez; Grace L Guo
Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development.
The Journal of pharmacology and experimental therapeutics 2009;328(2):469-77.
2008: Yuji Tanaka; Lauren M Aleksunes; Ronnie L Yeager; Maxwell Afari Gyamfi; Noriko Esterly; Grace L Guo; Curtis D Klaassen
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.
The Journal of pharmacology and experimental therapeutics 2008;325(2):655-64.
2007: Erik K Pacyniak; Xingguo Cheng; Michael L Cunningham; Kevin Crofton; Curtis D Klaassen; Grace L Guo
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):94-102.
2006: Kaori Nakamoto; Shuang Wang; Robert D Jenison; Grace L Guo; Curtis D Klaassen; Yu-Jui Yvonne Wan; Xiao-bo Zhong
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.
BMC genetics 2006;7():29.
2002: Grace L Guo; Jeff L Staudinger; Kenichiro Ogura; Curtis D Klaassen
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
Molecular pharmacology 2002;61(4):832-9.
2002: Grace L Guo; David R Johnson; Curtis D Klaassen
Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(3):283-8.
2002: Grace L Guo; Supratim Choudhuri; Curtis D Klaassen
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
The Journal of pharmacology and experimental therapeutics 2002;300(1):206-12.
2001: Grace L Guo; Curtis D Klaassen
Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake.
The Journal of pharmacology and experimental therapeutics 2001;299(2):551-7.