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Frances Arnold

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

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Sawayama Andrew M; Chen Michael M Y; Kulanthaivel Palaniappan; Kuo Ming-Shang; Hemmerle Horst; Arnold Frances H
A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.
Lewis Jared C; Bastian Sabine; Bennett Clay S; Fu Yu; Mitsuda Yuuichi; Chen Mike M; Greenberg William A; Wong Chi-Huey; Arnold Frances H
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases.
Heinzelman Pete; Snow Christopher D; Smith Matthew A; Yu Xinlin; Kannan Arvind; Boulware Kevin; Villalobos Alan; Govindarajan Sridhar; Minshull Jeremy; Arnold Frances H
SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability.

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All Publications

2009: Sawayama Andrew M; Chen Michael M Y; Kulanthaivel Palaniappan; Kuo Ming-Shang; Hemmerle Horst; Arnold Frances H
A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(43):11723-9.
2009: Lewis Jared C; Bastian Sabine; Bennett Clay S; Fu Yu; Mitsuda Yuuichi; Chen Mike M; Greenberg William A; Wong Chi-Huey; Arnold Frances H
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16550-5.
2009: Heinzelman Pete; Snow Christopher D; Smith Matthew A; Yu Xinlin; Kannan Arvind; Boulware Kevin; Villalobos Alan; Govindarajan Sridhar; Minshull Jeremy; Arnold Frances H
SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability.
The Journal of biological chemistry 2009;284(39):26229-33.
2009: Dougherty Michael J; Arnold Frances H
Directed evolution: new parts and optimized function.
Current opinion in biotechnology 2009;20(4):486-91.
2009: Bloom Jesse D; Arnold Frances H
In the light of directed evolution: pathways of adaptive protein evolution.
Proceedings of the National Academy of Sciences of the United States of America 2009;106 Suppl 1():9995-10000.
2009: Heinzelman Pete; Snow Christopher D; Wu Indira; Nguyen Catherine; Villalobos Alan; Govindarajan Sridhar; Minshull Jeremy; Arnold Frances H
A family of thermostable fungal cellulases created by structure-guided recombination.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5610-5.
2009: Tracewell Cara A; Arnold Frances H
Directed enzyme evolution: climbing fitness peaks one amino acid at a time.
Current opinion in chemical biology 2009;13(1):3-9.
2009: Koch Daniel J; Chen Mike M; van Beilen Jan B; Arnold Frances H
In vivo evolution of butane oxidation by terminal alkane hydroxylases AlkB and CYP153A6.
Applied and environmental microbiology 2009;75(2):337-44.
2008: Fasan Rudi; Meharenna Yergalem T; Snow Christopher D; Poulos Thomas L; Arnold Frances H
Evolutionary history of a specialized p450 propane monooxygenase.
Journal of molecular biology 2008;383(5):1069-80.
2008: Brenner Katie; You Lingchong; Arnold Frances H
Engineering microbial consortia: a new frontier in synthetic biology.
Trends in biotechnology 2008;26(9):483-9.
2008: Haseltine Eric L; Arnold Frances H
Implications of rewiring bacterial quorum sensing.
Applied and environmental microbiology 2008;74(2):437-45.
2007: Brenner Katie; Karig David K; Weiss Ron; Arnold Frances H
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17300-4.
2007: Li Yougen; Drummond D Allan; Sawayama Andrew M; Snow Christopher D; Bloom Jesse D; Arnold Frances H
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
Nature biotechnology 2007;25(9):1051-6.
2007: Hawkins Andrew C; Arnold Frances H; Stuermer Rainer; Hauer Bernhard; Leadbetter Jared R
Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone.
Applied and environmental microbiology 2007;73(18):5775-81.
2007: Carbone Martina N; Arnold Frances H
Engineering by homologous recombination: exploring sequence and function within a conserved fold.
Current opinion in structural biology 2007;17(4):454-9.
2007: Landwehr Marco; Carbone Martina; Otey Christopher R; Li Yougen; Arnold Frances H
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s.
Chemistry & biology 2007;14(3):269-78.
2007: Fasan Rudi; Chen Mike M; Crook Nathan C; Arnold Frances H
Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties.
Angewandte Chemie (International ed. in English) 2007;46(44):8414-8.
2007: Bloom Jesse D; Lu Zhongyi; Chen David; Raval Alpan; Venturelli Ophelia S; Arnold Frances H
Evolution favors protein mutational robustness in sufficiently large populations.
BMC biology 2007;5():29.
2007: Bloom Jesse D; Romero Philip A; Lu Zhongyi; Arnold Frances H
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.
Biology direct 2007;2():17.
2007: Bloom Jesse D; Arnold Frances H; Wilke Claus O
Breaking proteins with mutations: threads and thresholds in evolution.
Molecular systems biology 2007;3():76.
2007: Haseltine Eric L; Arnold Frances H
Synthetic gene circuits: design with directed evolution.
Annual review of biophysics and biomolecular structure 2007;36():1-19.
2006: Meyer Michelle M; Hochrein Lisa; Arnold Frances H
Structure-guided SCHEMA recombination of distantly related beta-lactamases.
Protein engineering, design & selection : PEDS 2006;19(12):563-70.
2006: Bloom Jesse D; Drummond D Allan; Arnold Frances H; Wilke Claus O
Structural determinants of the rate of protein evolution in yeast.
Molecular biology and evolution 2006;23(9):1751-61.
2006: Meyer Michelle M; Hiraga Kaori; Arnold Frances H
Combinatorial recombination of gene fragments to construct a library of chimeras.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2006;Chapter 26():Unit 26.2.
2006: Collins Cynthia H; Leadbetter Jared R; Arnold Frances H
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR.
Nature biotechnology 2006;24(6):708-12.
2006: Landwehr Marco; Hochrein Lisa; Otey Christopher R; Kasrayan Alex; Bäckvall Jan-E; Arnold Frances H
Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.
Journal of the American Chemical Society 2006;128(18):6058-9.
2006: Otey Christopher R; Landwehr Marco; Endelman Jeffrey B; Hiraga Kaori; Bloom Jesse D; Arnold Frances H
Structure-guided recombination creates an artificial family of cytochromes P450.
PLoS biology 2006;4(5):e112.
2006: Bloom Jesse D; Labthavikul Sy T; Otey Christopher R; Arnold Frances H
Protein stability promotes evolvability.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5869-74.
2006: Tobias Alexander V; Arnold Frances H
Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways.
Biochimica et biophysica acta 2006;1761(2):235-46.
2006: Otey Christopher R; Bandara Geethani; Lalonde James; Takahashi Katsuyuki; Arnold Frances H
Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.
Biotechnology and bioengineering 2006;93(3):494-9.
2006: Kubo Takafumi; Peters Matthew W; Meinhold Peter; Arnold Frances H
Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(4):1216-20.
2005: Drummond D Allan; Bloom Jesse D; Adami Christoph; Wilke Claus O; Arnold Frances H
Why highly expressed proteins evolve slowly.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14338-43.
2005: Meinhold Peter; Peters Matthew W; Chen Michael M Y; Takahashi Katsuyuki; Arnold Frances H
Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.
Chembiochem : a European journal of chemical biology 2005;6(10):1765-8.
2005: Bloom Jesse D; Meyer Michelle M; Meinhold Peter; Otey Christopher R; MacMillan Derek; Arnold Frances H
Evolving strategies for enzyme engineering.
Current opinion in structural biology 2005;15(4):447-52.
2005: Balagaddé Frederick K; You Lingchong; Hansen Carl L; Arnold Frances H; Quake Stephen R
Long-term monitoring of bacteria undergoing programmed population control in a microchemostat.
Science (New York, N.Y.) 2005;309(5731):137-40.
2005: Drummond D Allan; Iverson Brent L; Georgiou George; Arnold Frances H
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins.
Journal of molecular biology 2005;350(4):806-16.
2005: Udit Andrew K; Hindoyan Nareen; Hill Michael G; Arnold Frances H; Gray Harry B
Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3.
Inorganic chemistry 2005;44(12):4109-11.
2005: Münzer Dieter F; Meinhold Peter; Peters Matthew W; Feichtenhofer Sabine; Griengl Herfried; Arnold Frances H; Glieder Anton; de Raadt Anna
Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3.
Chemical communications (Cambridge, England) 2005;(20):2597-9.
2005: Drummond D Allan; Silberg Jonathan J; Meyer Michelle M; Wilke Claus O; Arnold Frances H
On the conservative nature of intragenic recombination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(15):5380-5.
2005: Umeno Daisuke; Tobias Alexander V; Arnold Frances H
Diversifying carotenoid biosynthetic pathways by directed evolution.
Microbiology and molecular biology reviews : MMBR 2005;69(1):51-78.
2005: Collins Cynthia H; Arnold Frances H; Leadbetter Jared R
Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones.
Molecular microbiology 2005;55(3):712-23.
2005: Bloom Jesse D; Silberg Jonathan J; Wilke Claus O; Drummond D Allan; Adami Christoph; Arnold Frances H
Thermodynamic prediction of protein neutrality.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):606-11.
2004: Udit Andrew K; Arnold Frances H; Gray Harry B
Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3.
Journal of inorganic biochemistry 2004;98(9):1547-50.
2004: Udit Andrew K; Hill Michael G; Bittner V Garrett; Arnold Frances H; Gray Harry B
Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes.
Journal of the American Chemical Society 2004;126(33):10218-9.
2004: Endelman Jeffrey B; Silberg Jonathan J; Wang Zhen-Gang; Arnold Frances H
Site-directed protein recombination as a shortest-path problem.
Protein engineering, design & selection : PEDS 2004;17(7):589-94.
2004: Bloom Jesse D; Wilke Claus O; Arnold Frances H; Adami Christoph
Stability and the evolvability of function in a model protein.
Biophysical journal 2004;86(5):2758-64.
2004: You Lingchong; Cox Robert Sidney; Weiss Ron; Arnold Frances H
Programmed population control by cell-cell communication and regulated killing.
Nature 2004;428(6985):868-71.
2004: Otey Christopher R; Silberg Jonathan J; Voigt Christopher A; Endelman Jeffrey B; Bandara Geethani; Arnold Frances H
Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach.
Chemistry & biology 2004;11(3):309-18.
2004: Alcalde Miguel; Farinas Edgardo T; Arnold Frances H
Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2004;9(2):141-6.
2004: Umeno Daisuke; Arnold Frances H
Evolution of a pathway to novel long-chain carotenoids.
Journal of bacteriology 2004;186(5):1531-6.
2004: Wong Tuck Seng; Arnold Frances H; Schwaneberg Ulrich
Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents.
Biotechnology and bioengineering 2004;85(3):351-8.
2004: Silberg Jonathan J; Endelman Jeffrey B; Arnold Frances H
SCHEMA-guided protein recombination.
Methods in enzymology 2004;388():35-42.
2003: Collins Cynthia H; Yokobayashi Yohei; Umeno Daisuke; Arnold Frances H
Engineering proteins that bind, move, make and break DNA.
Current opinion in biotechnology 2003;14(6):665.
2003: Peters Matthew W; Meinhold Peter; Glieder Anton; Arnold Frances H
Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.
Journal of the American Chemical Society 2003;125(44):13442-50.
2003: Salazar Oriana; Cirino Patrick C; Arnold Frances H
Thermostabilization of a cytochrome p450 peroxygenase.
Chembiochem : a European journal of chemical biology 2003;4(9):891-3.
2003: Cirino Patrick C; Tang Yi; Takahashi Katsuyuki; Tirrell David A; Arnold Frances H
Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity.
Biotechnology and bioengineering 2003;83(6):729-34.
2003: Collins Cynthia H; Yokobayashi Yohei; Umeno Daisuke; Arnold Frances H
Engineering proteins that bind, move, make and break DNA.
Current opinion in biotechnology 2003;14(4):371-8.
2003: Umeno Daisuke; Hiraga Kaori; Arnold Frances H
Method to protect a targeted amino acid residue during random mutagenesis.
Nucleic acids research 2003;31(16):e91.
2003: Meyer Michelle M; Silberg Jonathan J; Voigt Christopher A; Endelman Jeffrey B; Mayo Stephen L; Wang Zhen-Gang; Arnold Frances H
Library analysis of SCHEMA-guided protein recombination.
Protein science : a publication of the Protein Society 2003;12(8):1686-93.
2003: Cirino Patrick C; Arnold Frances H
A self-sufficient peroxide-driven hydroxylation biocatalyst.
Angewandte Chemie (International ed. in English) 2003;42(28):3299-301.
2003: Hiraga Kaori; Arnold Frances H
General method for sequence-independent site-directed chimeragenesis.
Journal of molecular biology 2003;330(2):287-96.
2003: Umeno Daisuke; Arnold Frances H
A C35 carotenoid biosynthetic pathway.
Applied and environmental microbiology 2003;69(6):3573-9.
2003: Wintrode Patrick L; Zhang Deqiang; Vaidehi Nagarajan; Arnold Frances H; Goddard William A
Protein dynamics in a family of laboratory evolved thermophilic enzymes.
Journal of molecular biology 2003;327(3):745-57.
2003: Bulter Thomas; Alcalde Miguel; Sieber Volker; Meinhold Peter; Schlachtbauer Christian; Arnold Frances H
Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution.
Applied and environmental microbiology 2003;69(2):987-95.
2002: Alcalde Miguel; Bulter Thomas; Arnold Frances H
Colorimetric assays for biodegradation of polycyclic aromatic hydrocarbons by fungal laccases.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2002;7(6):547-53.
2002: Yokobayashi Yohei; Weiss Ron; Arnold Frances H
Directed evolution of a genetic circuit.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16587-91.
2002: Umeno Daisuke; Tobias Alexander V; Arnold Frances H
Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway.
Journal of bacteriology 2002;184(23):6690-9.
2002: Glieder Anton; Farinas Edgardo T; Arnold Frances H
Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase.
Nature biotechnology 2002;20(11):1135-9.
2002: Sun Lianhong; Bulter Thomas; Alcalde Miguel; Petrounia Ioanna P; Arnold Frances H
Modification of galactose oxidase to introduce glucose 6-oxidase activity.
Chembiochem : a European journal of chemical biology 2002;3(8):781-3.
2002: Voigt Christopher A; Martinez Carlos; Wang Zhen-Gang; Mayo Stephen L; Arnold Frances H
Protein building blocks preserved by recombination.
Nature structural biology 2002;9(7):553-8.
2002: Fu Anne Y; Chou Hou-Pu; Spence Charles; Arnold Frances H; Quake Stephen R
An integrated microfabricated cell sorter.
Analytical chemistry 2002;74(11):2451-7.
2002: Cirino Patrick C; Arnold Frances H
Protein engineering of oxygenases for biocatalysis.
Current opinion in chemical biology 2002;6(2):130-5.
2002: Mayer Kimberly M; Arnold Frances H
A colorimetric assay to quantify dehydrogenase activity in crude cell lysates.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2002;7(2):135-40.
2002: Joern John M; Meinhold Peter; Arnold Frances H
Analysis of shuffled gene libraries.
Journal of molecular biology 2002;316(3):643-56.
2001: Farinas E T; Bulter T; Arnold F H
Directed enzyme evolution.
Current opinion in biotechnology 2001;12(6):545-51.
2001: Sun L; Petrounia I P; Yagasaki M; Bandara G; Arnold F H
Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution.
Protein engineering 2001;14(9):699-704.
2001: Wintrode P L; Miyazaki K; Arnold F H
Patterns of adaptation in a laboratory evolved thermophilic enzyme.
Biochimica et biophysica acta 2001;1549(1):1-8.
2001: Sakamoto T; Joern J M; Arisawa A; Arnold F H
Laboratory evolution of toluene dioxygenase to accept 4-picoline as a substrate.
Applied and environmental microbiology 2001;67(9):3882-7.
2001: Morawski B; Quan S; Arnold F H
Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae.
Biotechnology and bioengineering 2001;76(2):99-107.
2001: Joern J M; Sakamoto T; Arisawa A; Arnold F H
A versatile high throughput screen for dioxygenase activity using solid-phase digital imaging.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2001;6(4):219-23.
2001: Sieber V; Martinez C A; Arnold F H
Libraries of hybrid proteins from distantly related sequences.
Nature biotechnology 2001;19(5):456-60.
2001: Schwaneberg U; Otey C; Cirino P C; Farinas E; Arnold F H
Cost-effective whole-cell assay for laboratory evolution of hydroxylases in Escherichia coli.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2001;6(2):111-7.
2001: Thorsen T; Roberts R W; Arnold F H; Quake S R
Dynamic pattern formation in a vesicle-generating microfluidic device.
Physical review letters 2001;86(18):4163-6.
2001: Voigt C A; Mayo S L; Arnold F H; Wang Z G
Computational method to reduce the search space for directed protein evolution.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3778-83.
2001: Arnold F H; Wintrode P L; Miyazaki K; Gershenson A
How enzymes adapt: lessons from directed evolution.
Trends in biochemical sciences 2001;26(2):100-6.
2001: Arnold F H
Combinatorial and computational challenges for biocatalyst design.
Nature 2001;409(6817):253-7.
2001: Voigt C A; Mayo S L; Arnold F H; Wang Z G
Computationally focusing the directed evolution of proteins.
Journal of cellular biochemistry. Supplement 2001;Suppl 37():58-63.
2000: Wintrode P L; Miyazaki K; Arnold F H
Cold adaptation of a mesophilic subtilisin-like protease by laboratory evolution.
The Journal of biological chemistry 2000;275(41):31635-40.
2000: Petrounia I P; Arnold F H
Designed evolution of enzymatic properties.
Current opinion in biotechnology 2000;11(4):325-30.
2000: Morawski B; Lin Z; Cirino P; Joo H; Bandara G; Arnold F H
Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris.
Protein engineering 2000;13(5):377-84.
2000: Gershenson A; Schauerte J A; Giver L; Arnold F H
Tryptophan phosphorescence study of enzyme flexibility and unfolding in laboratory-evolved thermostable esterases.
Biochemistry 2000;39(16):4658-65.
2000: Miyazaki K; Wintrode P L; Grayling R A; Rubingh D N; Arnold F H
Directed evolution study of temperature adaptation in a psychrophilic enzyme.
Journal of molecular biology 2000;297(4):1015-26.
2000: May O; Nguyen P T; Arnold F H
Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine.
Nature biotechnology 2000;18(3):317-20.
2000: Gershenson A; Arnold F H
Enzyme stabilization by directed evolution.
Genetic engineering 2000;22():55-76.
2000: Wintrode P L; Arnold F H
Temperature adaptation of enzymes: lessons from laboratory evolution.
Advances in protein chemistry 2000;55():161-225.
1999: Miyazaki K; Arnold F H
Exploring nonnatural evolutionary pathways by saturation mutagenesis: rapid improvement of protein function.
Journal of molecular evolution 1999;49(6):716-20.
1999: Fu A Y; Spence C; Scherer A; Arnold F H; Quake S R
A microfabricated fluorescence-activated cell sorter.
Nature biotechnology 1999;17(11):1109-11.
1999: Joo H; Arisawa A; Lin Z; Arnold F H
A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases.
Chemistry & biology 1999;6(10):699-706.
1999: Volkov A A; Shao Z; Arnold F H
Recombination and chimeragenesis by in vitro heteroduplex formation and in vivo repair.
Nucleic acids research 1999;27(18):e18.
1999: Joo H; Lin Z; Arnold F H
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation.
Nature 1999;399(6737):670-3.
1999: Arnold F H; Giver L; Gershenson A; Zhao H; Miyazaki K
Directed evolution of mesophilic enzymes into their thermophilic counterparts.
Annals of the New York Academy of Sciences 1999;870():400-3.
1999: Lin Z; Thorsen T; Arnold F H
Functional expression of horseradish peroxidase in E. coli by directed evolution.
Biotechnology progress 1999;15(3):467-71.
1999: Schmidt-Dannert C; Arnold F H
Directed evolution of industrial enzymes.
Trends in biotechnology 1999;17(4):135-6.
1999: Arnold F H; Volkov A A
Directed evolution of biocatalysts.
Current opinion in chemical biology 1999;3(1):54-9.
1999: Zhao H; Arnold F H
Directed evolution converts subtilisin E into a functional equivalent of thermitase.
Protein engineering 1999;12(1):47-53.
1998: Giver L; Gershenson A; Freskgard P O; Arnold F H
Directed evolution of a thermostable esterase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12809-13.
1998: Giver L; Arnold F H
Combinatorial protein design by in vitro recombination.
Current opinion in chemical biology 1998;2(3):335-8.
1998: Zhao H; Giver L; Shao Z; Affholter J A; Arnold F H
Molecular evolution by staggered extension process (StEP) in vitro recombination.
Nature biotechnology 1998;16(3):258-61.
1998: Arnold F H
Enzyme engineering reaches the boiling point.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2035-6.
1998: Shao Z; Zhao H; Giver L; Arnold F H
Random-priming in vitro recombination: an effective tool for directed evolution.
Nucleic acids research 1998;26(2):681-3.
1997: Kuchner O; Arnold F H
Directed evolution of enzyme catalysts.
Trends in biotechnology 1997;15(12):523-30.
1997: Moore J C; Jin H M; Kuchner O; Arnold F H
Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences.
Journal of molecular biology 1997;272(3):336-47.
1997: Zhao H; Arnold F H
Combinatorial protein design: strategies for screening protein libraries.
Current opinion in structural biology 1997;7(4):480-5.
1997: Zhao H; Arnold F H
Functional and nonfunctional mutations distinguished by random recombination of homologous genes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7997-8000.
1997: Pack D W; Arnold F H
Langmuir monolayer characterization of metal chelating lipids for protein targeting to membranes.
Chemistry and physics of lipids 1997;86(2):135-52.
1997: Chen G; Guan Z; Chen C T; Fu L; Sundaresan V; Arnold F H
A glucose-sensing polymer.
Nature biotechnology 1997;15(4):354-7.
1997: Zhao H; Arnold F H
Optimization of DNA shuffling for high fidelity recombination.
Nucleic acids research 1997;25(6):1307-8.
1997: Arnold F H; Moore J C
Optimizing industrial enzymes by directed evolution.
Advances in biochemical engineering/biotechnology 1997;58():1-14.
1996: Zhao H; Li Y; Arnold F H
Strategy for the directed evolution of a peptide ligase.
Annals of the New York Academy of Sciences 1996;799():1-5.
1996: Shao Z; Arnold F H
Engineering new functions and altering existing functions.
Current opinion in structural biology 1996;6(4):513-8.
1996: Frey W; Schief W R; Pack D W; Chen C T; Chilkoti A; Stayton P; Vogel V; Arnold F H
Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4937-41.
1996: Moore J C; Arnold F H
Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents.
Nature biotechnology 1996;14(4):458-67.
1996: Johnson R D; Todd R J; Arnold F H
Multipoint binding in metal-affinity chromatography II. Effect of pH and imidazole on chromatographic retention of engineered histidine-containing cytochromes c.
Journal of chromatography. A 1996;725(2):225-35.
1996: You L; Arnold F H
Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide.
Protein engineering 1996;9(1):77-83.
1995: Plunkett S D; Arnold F H
Molecularly imprinted polymers on silica: selective supports for high-performance ligand-exchange chromatography.
Journal of chromatography. A 1995;708(1):19-29.
1994: Arnold F H; Zhang J H
Metal-mediated protein stabilization.
Trends in biotechnology 1994;12(5):189-92.
1994: Todd R J; Johnson R D; Arnold F H
Multiple-site binding interactions in metal-affinity chromatography. I. Equilibrium binding of engineered histidine-containing cytochromes c.
Journal of chromatography. A 1994;662(1):13-26.
1993: Chen K; Arnold F H
Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5618-22.
1991: Chen K Q; Arnold F H
Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media.
Bio/technology (Nature Publishing Company) 1991;9(11):1073-7.
1991: Kellis J T; Todd R J; Arnold F H
Protein stabilization by engineered metal chelation.
Bio/technology (Nature Publishing Company) 1991;9(10):994-5.
1991: Arnold F H; Haymore B L
Engineered metal-binding proteins: purification to protein folding.
Science (New York, N.Y.) 1991;252(5014):1796-7.
1991: Wuenschell G E; Wen E; Todd R; Shnek D; Arnold F H
Chiral copper-chelate complexes alter selectivities in metal affinity protein partitioning.
Journal of chromatography 1991;543(2):345-54.
1991: Chen K Q; Robinson A C; Van Dam M E; Martinez P; Economou C; Arnold F H
Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media.
Biotechnology progress 1991;7(2):125-9.
1991: Suh S S; Haymore B L; Arnold F H
Characterization of His-X3-His sites in alpha-helices of synthetic metal-binding bovine somatotropin.
Protein engineering 1991;4(3):301-5.
1991: Arnold F H
Metal-affinity separations: a new dimension in protein processing.
Bio/technology (Nature Publishing Company) 1991;9(2):151-6.
1991: Todd R J; Van Dam M E; Casimiro D; Haymore B L; Arnold F H
Cu(II)-binding properties of a cytochrome c with a synthetic metal-binding site: His-X3-His in an alpha-helix.
Proteins 1991;10(2):156-61.
1990: Arnold F H
Engineering enzymes for non-aqueous solvents.
Trends in biotechnology 1990;8(9):244-9.
1989: Van Dam M E; Wuenschell G E; Arnold F H
Metal affinity precipitation of proteins.
Biotechnology and applied biochemistry 1989;11(5):492-502.
1988: Arnold F H
Protein design for non-aqueous solvents.
Protein engineering 1988;2(1):21-5.

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