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Yiru Guo

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Kyung U Hong; Qian-Hong Li; Afsoon Moktar; Nikita S Patton; Aruni Bhatnagar; Yiru Guo; Roberto Bolli
A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice.
Chuanxi Cai; Yiru Guo; Jia-Qiang He; Qianghong Li; Gregg Rokosh; Xian-Liang Tang; Lei Teng; Duc Vu; Aruni Bhatnagar; Roberto Bolli
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release.
Yiru Guo; Qianhong Li; Wei Tan; Wen-Jian Wu; Xiaoping Zhu; Michael P Flaherty; Roberto Bolli
Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice.

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2013: Kyung U Hong; Qian-Hong Li; Afsoon Moktar; Nikita S Patton; Aruni Bhatnagar; Yiru Guo; Roberto Bolli
A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice.
Basic research in cardiology 2013;108(3):346.
2012: Chuanxi Cai; Yiru Guo; Jia-Qiang He; Qianghong Li; Gregg Rokosh; Xian-Liang Tang; Lei Teng; Duc Vu; Aruni Bhatnagar; Roberto Bolli
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release.
The Journal of biological chemistry 2012;287(40):33720-32.
2012: Yiru Guo; Qianhong Li; Wei Tan; Wen-Jian Wu; Xiaoping Zhu; Michael P Flaherty; Roberto Bolli
Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice.
Basic research in cardiology 2012;107(5):288.
2012: Yiru Guo; Yiming Huang; Suzanne T Ildstad; Qianhong Li; Santosh K Sanganalmath; Wei Tan; Wenjian Wu; Xiaoping Zhu; Roberto Bolli
Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury.
Basic research in cardiology 2012;107(2):253.
2012: Yiru Guo; Steven P Jones; Qianhong Li; Shuh Narumiya; Gregg Rokosh; Wei Tan; Deepali Nivas Tukaye; Wen-Jian Wu; Xiaoping Zhu; Michael Book; Roberto Bolli
The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning.
PloS one 2012;7(7):e41178.
2011: Qianhong Li; Li Luo; Qinghui Ou; Wei Tan; Wen-Jian Wu; Fangping Yuan; Xiaoping Zhu; Ning Chen; Buddhadeb Dawn; Yiru Guo; Gregory N Hunt; Roberto Bolli
Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences.
Basic research in cardiology 2011;106(6):1367-77.
2011: Qianhong Li; Li Luo; Erin O'Brien; Qinghui Ou; Wei Tan; Wen-Jian Wu; Fangping Yuan; Xiaoping Zhu; Ning Chen; Buddhadeb Dawn; Yiru Guo; Roberto Bolli
Gene transfer as a strategy to achieve permanent cardioprotection I: rAAV-mediated gene therapy with inducible nitric oxide synthase limits infarct size 1 year later without adverse functional consequences.
Basic research in cardiology 2011;106(6):1355-66.
2011: Qianhong Li; Li Luo; Erin O'Brien; Qinghui Ou; Tao Wang; Wen-Jian Wu; Fangping Yuan; Xiaoping Zhu; Ning Chen; Yiru Guo; Gregory N Hunt; Roberto Bolli
Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models.
Basic research in cardiology 2011;106(5):849-64.
2011: Ewa K Zuba-Surma; Yiru Guo; Hisham Taher; Santosh K Sanganalmath; Greg Hunt; Robert J Vincent; Magda Kucia; Ahmed Abdel-Latif; Xian-Liang Tang; Mariusz Z Ratajczak; Buddhadeb Dawn; Roberto Bolli
Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction.
Journal of cellular and molecular medicine 2011;15(6):1319-28.
2011: Roberto Bolli; Adam B Stein; Yiru Guo; Ou-Li Wang; Gregg Rokosh; Buddhadeb Dawn; Jeffery D Molkentin; Santosh K Sanganalmath; Yanqing Zhu; Yu-Ting Xuan
A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning.
Journal of molecular and cellular cardiology 2011;50(4):589-97.
2009: Santosh K Sanganalmath; Adam B Stein; Yiru Guo; Sumit Tiwari; Greg Hunt; Robert J Vincent; Yiming Huang; Arash Rezazadeh; Suzanne Ildstad; Buddhadeb Dawn; Roberto Bolli
The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up.
Journal of molecular and cellular cardiology 2009;47(4):528-35.
2009: Qianhong Li; Yiru Guo; Qinghui Ou; Chuanjue Cui; Wen-Jian Wu; Wei Tan; Xiaoping Zhu; Lilibeth B Lanceta; Santosh K Sanganalmath; Buddhadeb Dawn; Ken Shinmura; Gregg Rokosh; Shuyan Wang; Roberto Bolli
Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway.
Circulation 2009;120(13):1222-30.
2008: Michael P Flaherty; Yiru Guo; Sumit Tiwari; Arash Rezazadeh; Greg Hunt; Santosh K Sanganalmath; Xian-Liang Tang; Roberto Bolli; Buddhadeb Dawn
The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning.
Journal of molecular and cellular cardiology 2008;45(6):735-41.
2008: Matthew B West; Gregg Rokosh; Detlef Obal; Murugesan Velayutham; Yu-Ting Xuan; Bradford G Hill; Rachel J Keith; Jürgen Schrader; Yiru Guo; Daniel J Conklin; Sumanth D Prabhu; Jay L Zweier; Roberto Bolli; Aruni Bhatnagar
Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.
Circulation 2008;118(19):1970-8.
2008: Guang-Wu Wang; Yiru Guo; Thomas M Vondriska; Jun Zhang; Su Zhang; Linda L Tsai; Nobel C Zong; Roberto Bolli; Aruni Bhatnagar; Sumanth D Prabhu
Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection.
Journal of molecular and cellular cardiology 2008;44(6):1016-22.
2008: Buddhadeb Dawn; Sumit Tiwari; Magdalena J Kucia; Ewa K Zuba-Surma; Yiru Guo; Santosh K Sanganalmath; Ahmed Abdel-Latif; Greg Hunt; Robert J Vincent; Hisham Taher; Nathan J Reed; Mariusz Z Ratajczak; Roberto Bolli
Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction.
Stem cells (Dayton, Ohio) 2008;26(6):1646-55.
2008: Ewa K Zuba-Surma; Magda Kucia; Buddhadeb Dawn; Yiru Guo; Mariusz Z Ratajczak; Roberto Bolli
Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction.
Journal of molecular and cellular cardiology 2008;44(5):865-73.
2008: Yiru Guo; Qianhong Li; Wen-Jian Wu; Wei Tan; Xiaoping Zhu; Jingyao Mu; Roberto Bolli
Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse.
Journal of molecular and cellular cardiology 2008;44(3):496-501.
2007: Roberto Bolli; Qian-Hong Li; Xian-Liang Tang; Yiru Guo; Yu-Ting Xuan; Gregg Rokosh; Buddhadeb Dawn
The late phase of preconditioning and its natural clinical application--gene therapy.
Heart failure reviews 2007;12(3-4):189-99.
2007: Ivor J Benjamin; Yiru Guo; Sathyanarayanan Srinivasan; Sihem Boudina; Ryan P Taylor; Namakkal S Rajasekaran; Roberta Gottlieb; Eric F Wawrousek; E Dale Abel; Roberto Bolli
CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3201-9.
2007: Qianhong Li; Yiru Guo; Wei Tan; Qinghui Ou; Wen-Jian Wu; Diana Sturza; Buddhadeb Dawn; Greg Hunt; Chuanjue Cui; Roberto Bolli
Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway.
Circulation 2007;116(14):1577-84.
2007: Xiaofeng Hu; Shujing Dai; Wen-Jian Wu; Wei Tan; Xiaoping Zhu; Jingyao Mu; Yiru Guo; Roberto Bolli; Gregg Rokosh
Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis.
Circulation 2007;116(6):654-63.
2007: Yu-Ting Xuan; Yiru Guo; Yanqing Zhu; Ou-Li Wang; Gregg Rokosh; Roberto Bolli
Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1/3 pathway.
Circulation 2007;116(5):535-44.
2007: Adam B Stein; Roberto Bolli; Yiru Guo; Ou-Li Wang; Wei Tan; Wen-Jian Wu; Xiaoping Zhu; Yanqing Zhu; Yu-Ting Xuan
The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis.
Journal of molecular and cellular cardiology 2007;42(6):1075-85.
2006: Buddhadeb Dawn; Yiru Guo; Arash Rezazadeh; Yiming Huang; Adam B Stein; Greg Hunt; Sumit Tiwari; Jai Varma; Yan Gu; Sumanth D Prabhu; Jan Kajstura; Piero Anversa; Suzanne Ildstad; Roberto Bolli
Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function.
Circulation research 2006;98(8):1098-105.
2006: Qianhong Li; Yiru Guo; Wei Tan; Adam B Stein; Buddhadeb Dawn; Wen-Jian Wu; Xiaoping Zhu; Xiaoqin Lu; Xiaoming Xu; Tariq Siddiqui; Sumit Tiwari; Roberto Bolli
Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H584-9.
2005: Yiru Guo; Adam B Stein; Wen-Jian Wu; Xiaoping Zhu; Wei Tan; Qianhong Li; Roberto Bolli
Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS.
American journal of physiology. Heart and circulatory physiology 2005;289(5):H2251-7.
2005: Yu-Ting Xuan; Yiru Guo; Yanqing Zhu; Ou-Li Wang; Gregg Rokosh; Robert O Messing; Roberto Bolli
Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning.
Circulation 2005;112(13):1971-8.
2005: Faisal M Syed; Harvey S Hahn; Amy Odley; Yiru Guo; Jesus G Vallejo; Roy A Lynch; Douglas L Mann; Roberto Bolli; Gerald W Dorn
Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia.
Circulation research 2005;96(10):1103-9.
2005: Joshua Martindale; Jason A Wall; Diana M Martinez-Longoria; Prafulla Aryal; Howard A Rockman; Yiru Guo; Roberto Bolli; Christopher C Glembotski
Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.
The Journal of biological chemistry 2005;280(1):669-76.
2005: Adam B Stein; Yiru Guo; Wei Tan; Wen-Jian Wu; Xiaoping Zhu; Qianhong Li; Cheng Luo; Buddhadeb Dawn; Tony R Johnson; Roberto Motterlini; Roberto Bolli
Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction.
Journal of molecular and cellular cardiology 2005;38(1):127-34.
2004: Magda Kucia; Buddhadeb Dawn; Greg Hunt; Yiru Guo; Marcin Wysoczynski; Marcin Majka; Janina Ratajczak; Francine Rezzoug; Suzanne Ildstad; Roberto Bolli; Mariusz Z Ratajczak
Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction.
Circulation research 2004;95(12):1191-9.
2004: Adam B Stein; Xian-Liang Tang; Yiru Guo; Yu-Ting Xuan; Buddhadeb Dawn; Roberto Bolli
Delayed adaptation of the heart to stress: late preconditioning.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2676-9.
2004: Buddhadeb Dawn; Yu-Ting Xuan; Yiru Guo; Arash Rezazadeh; Adam B Stein; Greg Hunt; Wen-Jian Wu; Wei Tan; Roberto Bolli
IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.
Cardiovascular research 2004;64(1):61-71.
2004: Buddhadeb Dawn; Yiru Guo; Arash Rezazadeh; Ou-Li Wang; Adam B Stein; Greg Hunt; Jai Varma; Yu-Ting Xuan; Wen-Jian Wu; Wei Tan; Xiaoping Zhu; Roberto Bolli
Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naïve myocardium but is essential for the development of late preconditioning.
Journal of molecular and cellular cardiology 2004;37(1):51-61.
2004: Yiru Guo; Adam B Stein; Wen-Jian Wu; Wei Tan; Xiaoping Zhu; Qian-Hong Li; Buddhadeb Dawn; Roberto Motterlini; Roberto Bolli
Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1649-53.
2003: Christopher P Baines; Chang-Xu Song; Yu-Ting Zheng; Guang-Wu Wang; Jun Zhang; Ou-Li Wang; Yiru Guo; Roberto Bolli; Ernest M Cardwell; Peipei Ping
Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria.
Circulation research 2003;92(8):873-80.
2003: Yu-Ting Xuan; Yiru Guo; Yanqing Zhu; Hui Han; Robert Langenbach; Buddhadeb Dawn; Roberto Bolli
Mechanism of cyclooxygenase-2 upregulation in late preconditioning.
Journal of molecular and cellular cardiology 2003;35(5):525-37.
2003: Qianhong Li; Yiru Guo; Yu-Ting Xuan; Charles J Lowenstein; Susan C Stevenson; Sumanth D Prabhu; Wen-Jian Wu; Yanqing Zhu; Roberto Bolli
Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanism.
Circulation research 2003;92(7):741-8.
2003: Norihito Sasaki; Mitsushige Murata; Yiru Guo; Su-Hyun Jo; Andreas Ohler; Masaharu Akao; Brian O'Rourke; Rui-Ping Xiao; Roberto Bolli; Eduardo Marban
MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
Circulation 2003;107(8):1183-8.
2002: Roberto Bolli; Ken Shinmura; Xian-Liang Tang; Eitaro Kodani; Yu-Ting Xuan; Yiru Guo; Buddhadeb Dawn
Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning.
Cardiovascular research 2002;55(3):506-19.
2002: Richard G Black; Yiru Guo; Zhi-Dong Ge; Sidney S Murphree; Sumanth D Prabhu; W Keith Jones; Roberto Bolli; John A Auchampach
Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor.
Circulation research 2002;91(2):165-72.
2002: Peipei Ping; Changxu Song; Jun Zhang; Yiru Guo; Xinan Cao; Richard C X Li; Wenjian Wu; Thomas M Vondriska; Jason M Pass; Xian-Liang Tang; William M Pierce; Roberto Bolli
Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection.
The Journal of clinical investigation 2002;109(4):499-507.
2002: Yang Wang; Yiru Guo; Shelley X Zhang; Wen-Jian Wu; Jianxun Wang; Weike Bao; Roberto Bolli
Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyte.
Journal of molecular and cellular cardiology 2002;34(1):5-15.
2001: Yu-Ting Xuan; Yiru Guo; H Han; Yanqing Zhu; Roberto Bolli
An essential role of the JAK-STAT pathway in ischemic preconditioning.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9050-5.
2001: Qianhong Li; Roberto Bolli; Yumin Qiu; Xian-Liang Tang; Yiru Guo; BA French
Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction.
Circulation 2001;103(14):1893-8.
2001: Yiru Guo; Roberto Bolli; Weike Bao; Wen-Jian Wu; Richard G Black; Sidney S Murphree; C A Salvatore; M A Jacobson; John A Auchampach
Targeted deletion of the A3 adenosine receptor confers resistance to myocardial ischemic injury and does not prevent early preconditioning.
Journal of molecular and cellular cardiology 2001;33(4):825-30.
2000: Yiru Guo; Weike Bao; Wen-Jian Wu; Ken Shinmura; Xian-Liang Tang; Roberto Bolli
Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice.
Basic research in cardiology 2000;95(6):479-84.
1999: Yiru Guo; W Keith Jones; Yu-Ting Xuan; Xian-Liang Tang; Weike Bao; Wen-Jian Wu; H Han; V E Laubach; Peipei Ping; Z Yang; Yumin Qiu; Roberto Bolli
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11507-12.
1998: MD DuVall; Yiru Guo; Sadis Matalon
Hydrogen peroxide inhibits cAMP-induced Cl- secretion across colonic epithelial cells.
The American journal of physiology 1998;275(5 Pt 1):C1313-22.
1998: Roberto Bolli; Buddhadeb Dawn; Xian-Liang Tang; Yumin Qiu; Peipei Ping; Yu-Ting Xuan; W Keith Jones; Hitoshi Takano; Yiru Guo; Jun Zhang
The nitric oxide hypothesis of late preconditioning.
Basic research in cardiology 1998;93(5):325-38.
1998: Yiru Guo; Wen-Jian Wu; Yumin Qiu; Xian-Liang Tang; Z Yang; Roberto Bolli
Demonstration of an early and a late phase of ischemic preconditioning in mice.
The American journal of physiology 1998;275(4 Pt 2):H1375-87.
1998: Hitoshi Takano; Xian-Liang Tang; Yumin Qiu; Yiru Guo; BA French; Roberto Bolli
Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism.
Circulation research 1998;83(1):73-84.
1998: Yiru Guo; MD DuVall; John P Crow; Sadis Matalon
Nitric oxide inhibits Na+ absorption across cultured alveolar type II monolayers.
The American journal of physiology 1998;274(3 Pt 1):L369-77.
1997: Roberto Bolli; S Manchikalapudi; Xian-Liang Tang; Hitoshi Takano; Yumin Qiu; Yiru Guo; Qin Zhang; AK Jadoon
The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning.
Circulation research 1997;81(6):1094-107.
1997: SM Manuel; Yiru Guo; Sadis Matalon
Exosurf enhances adenovirus-mediated gene transfer to alveolar type II cells.
The American journal of physiology 1997;273(4 Pt 1):L741-8.
1997: Roberto Bolli; Z A Bhatti; Xian-Liang Tang; Yumin Qiu; Qin Zhang; Yiru Guo; AK Jadoon
Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide.
Circulation research 1997;81(1):42-52.
1997: Bakhrom K Berdiev; V Gh Shlyonsky; O Senyk; DA Keeton; Yiru Guo; Sadis Matalon; Horacio F Cantiello; Adriana G Prat; Dennis A Ausiello; Iskander I Ismailov; Dale J Benos
Protein kinase A phosphorylation and G protein regulation of type II pneumocyte Na+ channels in lipid bilayers.
The American journal of physiology 1997;272(4 Pt 1):C1262-70.