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Andreas Guse

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Chemicals & Drugs

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High Pressure Liquid Chromatography

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TOP 3
Frederike Schmid; Tim Westphal; Andreas Bauche; Ralf Fliegert; Andreas H Guse
Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.
Andreas H Guse
Linking NAADP to ion channel activity: a unifying hypothesis.
Nicole Schwarz; Annette Nicke; Sahil Adriouch; Olivier Boyer; Laurent Drouot; Ralf Fliegert; Andreas H Guse; Friedrich Haag; Friedrich Koch-Nolte
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

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All Publications

2012: Frederike Schmid; Tim Westphal; Andreas Bauche; Ralf Fliegert; Andreas H Guse
Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.
The Journal of biological chemistry 2012;287(39):32525-34.
2012: Andreas H Guse
Linking NAADP to ion channel activity: a unifying hypothesis.
Science signaling 2012;5(221):pe18.
2012: Nicole Schwarz; Annette Nicke; Sahil Adriouch; Olivier Boyer; Laurent Drouot; Ralf Fliegert; Andreas H Guse; Friedrich Haag; Friedrich Koch-Nolte
Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.
PloS one 2012;7(7):e41269.
2011: Frederike Schmid; Karin Weber; Sören Bruhn; Hans-Willi Mittrücker; Andreas H Guse
CD38: a NAADP degrading enzyme.
FEBS letters 2011;585(22):3544-8.
2011: N Qi; M Wang; Z J Yang; Andreas H Guse; K Jung; L X Na; Liang-Ren Zhang; Li-He Zhang
A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
Chemical communications (Cambridge, England) 2011;47(33):9462-4.
2010: Min Dong; Tanja Kirchberger; Xiangchen Huang; Zhen Jun Yang; Liang-Ren Zhang; Andreas H Guse; Li He Zhang
Trifluoromethylated cyclic-ADP-ribose mimic: synthesis of 8-trifluoromethyl-N(1)-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine-5',5''-cyclic pyrophosphate (8-CF(3)-cIDPRE) and its calcium release activity in T cells.
Organic & biomolecular chemistry 2010;8(20):4705-15.
2010: Santina Bruzzone; Giovanna Basile; Madhu Parakkottil Chothi; Lucilla Nobbio; Cesare Usai; Emanuela Jacchetti; Angelo Schenone; Andreas H Guse; Francesco Di Virgilio; Antonio De Flora; Elena Zocchi
Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.
The Journal of biological chemistry 2010;285(27):21165-74.
2010: Lingjun Li; Cornelia C Siebrands; Zhenjun Yang; Liangren Zhang; Andreas H Guse; Lihe Zhang
Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes.
Organic & biomolecular chemistry 2010;8(8):1843-8.
2009: Tanja Kirchberger; Christelle Moreau; Gerd K Wagner; Ralf Fliegert; Cornelia C Siebrands; Merle Nebel; Frederike Schmid; Angelika Harneit; Francesca Odoardi; Alexander Flügel; Barry V L Potter; Andreas H Guse
8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
The Biochemical journal 2009;422(1):139-49.
2009: Andreas H Guse
Second messenger signaling: multiple receptors for NAADP.
Current biology : CB 2009;19(13):R521-3.
2009: Nicole Schwarz; Ralf Fliegert; Sahil Adriouch; Michel Seman; Andreas H Guse; Friedrich Haag; Friedrich Koch-Nolte
Activation of the P2X7 ion channel by soluble and covalently bound ligands.
Purinergic signalling 2009;5(2):139-49.
2009: Friedrich Koch-Nolte; Friedrich Haag; Andreas H Guse; Frances Lund; Mathias Ziegler
Emerging roles of NAD+ and its metabolites in cell signaling.
Science signaling 2009;2(57):mr1.
2008: Sabine Windhorst; Christine Blechner; Hong-Ying Lin; Christian Elling; Marcus Nalaskowski; Tanja Kirchberger; Andreas H Guse; Georg W Mayr
Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
The Biochemical journal 2008;414(3):407-17.
2008: Sahil Adriouch; Peter Bannas; Nicole Schwarz; Ralf Fliegert; Andreas H Guse; Michel Seman; Friedrich Haag; Friedrich Koch-Nolte
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):861-9.
2008: Andreas H Guse; Hon Cheung Lee
NAADP: a universal Ca2+ trigger.
Science signaling 2008;1(44):re10.
2008: Andreas H Guse
Back from the dormant stage: second messenger cyclic ADP-ribose essential for Toxoplasma gondii pathogenicity.
Science signaling 2008;1(17):pe18.
2007: Santiago Partida-Sanchez; Andreas Gasser; Ralf Fliegert; Cornelia C Siebrands; Werner Dammermann; Guixiu Shi; Betty J Mousseau; Adriana Sumoza-Toledo; Harivadan Bhagat; Timothy F Walseth; Andreas H Guse; Frances E Lund
Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7827-39.
2007: Mareike Steen; Tanja Kirchberger; Andreas H Guse
NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes.
The Journal of biological chemistry 2007;282(26):18864-71.
2007: Ralf Fliegert; Günter Glassmeier; Frederike Schmid; Kerstin Cornils; Selda Genisyuerek; Angelika Harneit; Jürgen R Schwarz; Andreas H Guse
Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b.
The FEBS journal 2007;274(3):704-13.
2007: Ralf Fliegert; Andreas Gasser; Andreas H Guse
Regulation of calcium signalling by adenine-based second messengers.
Biochemical Society transactions 2007;35(Pt 1):109-14.
2006: T Kirchberger; G Wagner; J Xu; C Cordiglieri; P Wang; Andreas Gasser; Ralf Fliegert; S Bruhn; Alexander Flügel; Frances E Lund; L-H Zhang; Barry V L Potter; Andreas H Guse
Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.
British journal of pharmacology 2006;149(4):337-44.
2006: Jianfeng Xu; Zhenjun Yang; Werner Dammermann; Liangren Zhang; Andreas H Guse; Li-He Zhang
Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.
Journal of medicinal chemistry 2006;49(18):5501-12.
2006: Andreas Gasser; Sören Bruhn; Andreas H Guse
Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assay.
The Journal of biological chemistry 2006;281(25):16906-13.
2006: Andreas Gasser; Günter Glassmeier; Ralf Fliegert; Matthias F Langhorst; Stephan Meinke; Dörte Hein; Sylvia Krüger; Karin Weber; Inka Heiner; Norman Oppenheimer; Jürgen R Schwarz; Andreas H Guse
Activation of T cell calcium influx by the second messenger ADP-ribose.
The Journal of biological chemistry 2006;281(5):2489-96.
2005: Andreas H Guse
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
The FEBS journal 2005;272(18):4590-7.
2005: Andreas Gasser; Andreas H Guse
Determination of intracellular concentrations of the TRPM2 agonist ADP-ribose by reversed-phase HPLC.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;821(2):181-7.
2005: Takashi Kudoh; Masayoshi Fukuoka; Satoshi Ichikawa; Takashi Murayama; Yasuo Ogawa; Minako Hashii; Haruhiro Higashida; Svenja Kunerth; Karin Weber; Andreas H Guse; Barry V L Potter; Akira Matsuda; Satoshi Shuto
Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety.
Journal of the American Chemical Society 2005;127(24):8846-55.
2005: Werner Dammermann; Andreas H Guse
Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes.
The Journal of biological chemistry 2005;280(22):21394-9.
2005: Andreas H Guse; Xianfeng Gu; Liangren Zhang; Karin Weber; Elisabeth Krämer; Zhenjun Yang; Hongwei Jin; Qin Li; Lucie Carrier; Lihe Zhang
A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells.
The Journal of biological chemistry 2005;280(16):15952-9.
2004: Xianfeng Gu; Zhenjun Yang; Liangren Zhang; Svenja Kunerth; Ralf Fliegert; Karin Weber; Andreas H Guse; Lihe Zhang
Synthesis and biological evaluation of novel membrane-permeant cyclic ADP-ribose mimics: N1-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine 5',5''-cyclicpyrophosphate (cIDPRE) and 8-substituted derivatives.
Journal of medicinal chemistry 2004;47(23):5674-82.
2004: Claudia A O Stuermer; Matthias F Langhorst; Marianne F Wiechers; Daniel F Legler; Sylvia Hannbeck Von Hanwehr; Andreas H Guse; Helmut Plattner
PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1731-3.
2004: Matthias F Langhorst; Nadine Schwarzmann; Andreas H Guse
Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes.
Cellular signalling 2004;16(11):1283-9.
2004: Andreas H Guse
Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR).
Current molecular medicine 2004;4(3):239-48.
2004: Svenja Kunerth; Matthias F Langhorst; Nadine Schwarzmann; Xianfeng Gu; Lijun Huang; Zhenjun Yang; Liangren Zhang; Stephen Joseph Mills; Li-He Zhang; Barry V L Potter; Andreas H Guse
Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells.
Journal of cell science 2004;117(Pt 10):2141-9.
2004: Andreas H Guse
Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR).
Current medicinal chemistry 2004;11(7):847-55.
2003: Santina Bruzzone; Svenja Kunerth; Elena Zocchi; Antonio De Flora; Andreas H Guse
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors.
The Journal of cell biology 2003;163(4):837-45.
2003: Svenja Kunerth; Georg W Mayr; Friedrich Koch-Nolte; Andreas H Guse
Analysis of subcellular calcium signals in T-lymphocytes.
Cellular signalling 2003;15(8):783-92.
2002: Nadine Schwarzmann; Svenja Kunerth; Karin Weber; Georg W Mayr; Andreas H Guse
Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex.
The Journal of biological chemistry 2002;277(52):50636-42.
2002: Andreas H Guse; Céline Cakir-Kiefer; Masayoshi Fukuoka; Satoshi Shuto; Karin Weber; Victoria C Bailey; Akira Matsuda; Georg W Mayr; Norman Oppenheimer; Francis Schuber; Barry V L Potter
Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
Biochemistry 2002;41(21):6744-51.
2001: K Schweitzer; Georg W Mayr; Andreas H Guse
Assay for ADP-ribosyl cyclase by reverse-phase high-performance liquid chromatography.
Analytical biochemistry 2001;299(2):218-26.
2001: H Schöttelndreier; Barry V L Potter; Georg W Mayr; Andreas H Guse
Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.
Cellular signalling 2001;13(12):895-9.
2001: Martin Pfister; A Ogilvie; CP da Silva; Andreas Grahnert; Andreas H Guse; Sunna Hauschildt
NAD degradation and regulation of CD38 expression by human monocytes/macrophages.
European journal of biochemistry / FEBS 2001;268(21):5601-8.
2001: Andreas H Guse; Alexander Y Tsygankov; Klaus Weber; Georg W Mayr
Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation.
The Journal of biological chemistry 2001;276(37):34722-7.
2000: CP da Silva; Andreas H Guse
Intracellular Ca(2+) release mechanisms: multiple pathways having multiple functions within the same cell type?
Biochimica et biophysica acta 2000;1498(2-3):122-33.
2000: I Berg; Barry V L Potter; Georg W Mayr; Andreas H Guse
Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling.
The Journal of cell biology 2000;150(3):581-8.
2000: Andreas H Guse
Cyclic ADP-ribose.
Journal of molecular medicine (Berlin, Germany) 2000;78(1):26-35.
1999: Martin Hohenegger; I Berg; Lukas Weigl; Georg W Mayr; Barry V L Potter; Andreas H Guse
Pharmacological activation of the ryanodine receptor in Jurkat T-lymphocytes.
British journal of pharmacology 1999;128(6):1235-40.
1999: H Schöttelndreier; Georg W Mayr; Andreas H Guse
Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways.
Cellular signalling 1999;11(8):611-9.
1999: Andreas H Guse
Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger.
Cellular signalling 1999;11(5):309-16.
1999: Andreas H Guse; CP da Silva; I Berg; Alla Skapenko; Klaus Weber; P Heyer; Martin Hohenegger; G A Ashamu; H Schulze-Koops; Barry V L Potter; Georg W Mayr
Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
Nature 1999;398(6722):70-3.
1998: CP da Silva; K Schweitzer; P Heyer; F Malavasi; Georg W Mayr; Andreas H Guse
Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-signalling activity of cyclic ADP-ribose in T-lymphocytes are not functionally related.
FEBS letters 1998;439(3):291-6.
1998: CP da Silva; Barry V L Potter; Georg W Mayr; Andreas H Guse
Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1998;707(1-2):43-50.
1998: Andreas H Guse
Ca2+ signaling in T-lymphocytes.
Critical reviews in immunology 1998;18(5):419-48.
1997: U Bandyopadhyay; T Kaiser; M T Rudolf; C Schultz; Andreas H Guse; Georg W Mayr
Vicinal thiols are involved in inositol 1,2,3,5,6-pentakisphosphate 5-phosphatase activity from fetal calf thymus.
Biochemical and biophysical research communications 1997;240(1):146-9.
1997: Andreas H Guse; C de Wit; T Klokow; K Schweitzer; Georg W Mayr
Unique properties of the capacitative Ca(2+)-entry antagonist LU 52396: its inhibitory activity depends on the activation state of the cells.
Cell calcium 1997;22(2):91-7.
1997: Andreas H Guse; CP da Silva; Klaus Weber; C N Armah; G A Ashamu; C Schulze; Barry V L Potter; Georg W Mayr; H Hilz
1-(5-phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines.
European journal of biochemistry / FEBS 1997;245(2):411-7.
1997: Andreas H Guse; I Berg; CP da Silva; Barry V L Potter; Georg W Mayr
Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes.
The Journal of biological chemistry 1997;272(13):8546-50.
1997: M Weismann; Andreas H Guse; Lydia Sorokin; B Bröker; M Frieser; Rupert Hallmann; Georg W Mayr
Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1618-27.
1997: Andreas H Guse; CP da Silva; Barry V L Potter; Georg W Mayr
Ca(2+)-signalling in human T-lymphocytes. Potential roles for cyclic ADP-ribose and 2'-phospho-cyclic ADP-ribose.
Advances in experimental medicine and biology 1997;419():431-6.
1996: Andreas H Guse; C P Silva; Klaus Weber; G A Ashamu; B V Potter; Georg W Mayr
Regulation of cADP-ribose-induced Ca2+ release by Mg2+ and inorganic phosphate.
The Journal of biological chemistry 1996;271(39):23946-53.
1995: Andreas H Guse; A Goldwich; Klaus Weber; Georg W Mayr
Non-radioactive, isomer-specific inositol phosphate mass determinations: high-performance liquid chromatography-micro-metal-dye detection strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays.
Journal of chromatography. B, Biomedical applications 1995;672(2):189-98.
1995: Andreas H Guse; CP da Silva; Frank Emmrich; G A Ashamu; B V Potter; Georg W Mayr
Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3353-9.
1994: Andreas H Guse; E Roth; Frank Emmrich
Ca2+ release and Ca2+ entry induced by rapid cytosolic alkalinization in Jurkat T-lymphocytes.
The Biochemical journal 1994;301 ( Pt 1)():83-8.
1994: CP da Silva; Frank Emmrich; Andreas H Guse
Adriamycin inhibits inositol 1,4,5-trisphosphate 3-kinase activity in vitro and blocks formation of inositol 1,3,4,5-tetrakisphosphate in stimulated Jurkat T-lymphocytes. Does inositol 1,3,4,5-tetrakisphosphate play a role in Ca(2+)-entry?
The Journal of biological chemistry 1994;269(17):12521-6.
1994: Andreas H Guse; A D Milton; H Schulze-Koops; B Müller; E Roth; B Simmer; H Wächter; E Weiss; Frank Emmrich
Purification and analytical characterization of an anti-CD4 monoclonal antibody for human therapy.
Journal of chromatography. A 1994;661(1-2):13-23.
1993: Alexander Y Tsygankov; Barbara M Bröker; Andreas H Guse; U Meinke; E Roth; C Rossmann; Frank Emmrich
Preincubation with anti-CD4 influences activation of human T cells by subsequent co-cross-linking of CD4 with CD3.
Journal of leukocyte biology 1993;54(5):430-8.
1993: Barbara M Bröker; Alexander Y Tsygankov; I Müller-Fleckenstein; Andreas H Guse; N A Chitaev; Brigitte Biesinger; Bernhard Fleckenstein; Frank Emmrich
Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1184-92.
1993: Andreas H Guse; E Roth; Frank Emmrich
Intracellular Ca2+ pools in Jurkat T-lymphocytes.
The Biochemical journal 1993;291 ( Pt 2)():447-51.
1993: Gerd Horneff; Andreas H Guse; H Schulze-Koops; Joachim R Kalden; Gerd R Burmester; Frank Emmrich
Human CD4 modulation in vivo induced by antibody treatment.
Clinical immunology and immunopathology 1993;66(1):80-90.
1993: Andreas H Guse; Barbara M Bröker; E Roth; Frank Emmrich
Signal transduction in T lymphocytes and monocytes: effects of the anti-CD4 antibody MAX.16H5.
The Year in immunology 1993;7():175-81.
1992: Andreas H Guse; E Roth; Frank Emmrich
D-myo-inositol 1,3,4,5-tetrakisphosphate releases Ca2+ from crude microsomes and enriched vesicular plasma membranes, but not from intracellular stores of permeabilized T-lymphocytes and monocytes.
The Biochemical journal 1992;288 ( Pt 2)():489-95.
1992: Andreas H Guse; E Roth; Barbara M Bröker; Frank Emmrich
Complex inositol polyphosphate response induced by co-cross-linking of CD4 and Fc gamma receptors in the human monocytoid cell line U937.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(7):2452-8.
1992: Andreas H Guse; Frank Emmrich
Determination of inositol polyphosphates from human T-lymphocyte cell lines by anion-exchange high-performance liquid chromatography and post-column derivatization.
Journal of chromatography 1992;593(1-2):157-63.
1992: Andreas H Guse; Wieland Kiess; B Funk; U Kessler; I Berg; Günther Gercken
Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation.
Endocrinology 1992;130(1):145-51.
1991: Andreas H Guse; Frank Emmrich
T-cell receptor-mediated metabolism of inositol polyphosphates in Jurkat T-lymphocytes. Identification of a D-myo-inositol 1,2,3,4,6-pentakisphosphate-2-phosphomonoesterase activity, a D-myo-inositol 1,3,4,5,6-pentakisphosphate-1/3-phosphatase activity and a D/L-myo-inositol 1,2,4,5,6-pentakisphosphate-1/3-kinase activity.
The Journal of biological chemistry 1991;266(36):24498-502.
1991: Andreas H Guse; I Berg; Günther Gercken
Inhibition of alpha 1-adrenoceptor-mediated inositol phosphate accumulation in cultured cardiac myocytes by cyclic AMP-generating compounds.
Journal of molecular and cellular cardiology 1991;23(12):1375-82.
1991: Andreas H Guse; Günther Gercken; H Boysen; Jürgen R Schwarz; Wolfgang Meyerhof
Inositol tetrakisphosphates as second messengers induce Ca(++)-dependent chloride currents in Xenopus laevis oocytes.
Biochemical and biophysical research communications 1991;179(1):641-7.
1989: Andreas H Guse; I Berg; Günther Gercken
Metabolism of inositol phosphates in alpha 1-adrenoceptor-stimulated and homogenized cardiac myocytes of adult rats.
The Biochemical journal 1989;261(1):89-92.
1989: I Berg; Andreas H Guse; Günther Gercken
Carbamoylcholine-induced accumulation of inositol mono-, bis-, tris- and tetrakisphosphates in isolated cardiac myocytes from adult rats.
Biochimica et biophysica acta 1989;1010(1):100-7.