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Amy Arnsten

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Prefrontal Cortex

Living Beings

Chemicals & Drugs

Physiology

Concepts & Ideas

Drug Dose-Response Relationship

Disorders

Attention Deficit Disorder with Hyperactivity

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Network (preview)

Co-Publications
Name
7
Birnbaum, Shari
6
Li, Bao-Ming
6
Ramos, Brian
6
van Dyck, Christopher
5
Franowicz, Jenna
5
Goldman-Rakic, Patricia
4
Vijayraghavan, Susheel
3
Wang, Min
3
Taylor, Jane
3
Roth, Robert
3
Shansky, Rebecca
2
Paspalas, Constantinos
2
Avery, RA
2
Mao, ZM
1
Marek, Kenneth

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Publications

TOP 3
Hains Avis Brennan; Vu Mai Anh T; Maciejewski Paul K; van Dyck Christopher H; Gottron Melissa; Arnsten Amy F T
Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.
Paspalas Constantinos D; Selemon Lynn D; Arnsten Amy F T
Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex.
Arnsten Amy F T
Stress signalling pathways that impair prefrontal cortex structure and function.

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All Publications

2009: Hains Avis Brennan; Vu Mai Anh T; Maciejewski Paul K; van Dyck Christopher H; Gottron Melissa; Arnsten Amy F T
Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17957-62.
2009: Paspalas Constantinos D; Selemon Lynn D; Arnsten Amy F T
Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex.
Cerebral cortex (New York, N.Y. : 1991) 2009;19(9):2145-55.
2009: Arnsten Amy F T
Stress signalling pathways that impair prefrontal cortex structure and function.
Nature reviews. Neuroscience 2009;10(6):410-22.
2009: Brennan Avis R; Yuan Peixiong; Dickstein Dara L; Rocher Anne B; Hof Patrick R; Manji Husseini; Arnsten Amy F T
Protein kinase C activity is associated with prefrontal cortical decline in aging.
Neurobiology of aging 2009;30(5):782-92.
2009: Arnsten A F T
Ameliorating prefrontal cortical dysfunction in mental illness: inhibition of phosphotidyl inositol-protein kinase C signaling.
Psychopharmacology 2009;202(1-3):445-55.
2009: Arnsten Amy F T
Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction.
CNS drugs 2009;23 Suppl 1():33-41.
2008: Budel Stéphane; Padukkavidana Thihan; Liu Betty P; Feng Zeny; Hu Fenghua; Johnson Sam; Lauren Juha; Park James H; McGee Aaron W; Liao Ji; Stillman Althea; Kim Ji-Eun; Yang Bao-Zhu; Sodi Stefano; Gelernter Joel; Zhao Hongyu; Hisama Fuki; Arnsten Amy F T; Strittmatter Stephen M
Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(49):13161-72.
2008: van Dyck Christopher H; Avery Robert A; MacAvoy Martha G; Marek Kenneth L; Quinlan Donald M; Baldwin Ronald M; Seibyl John P; Innis Robert B; Arnsten Amy F T
Striatal dopamine transporters correlate with simple reaction time in elderly subjects.
Neurobiology of aging 2008;29(8):1237-46.
2008: Ramos Brian P; Colgan Leslie A; Nou Eric; Arnsten Amy F T
Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals.
Neurobiology of aging 2008;29(7):1060-9.
2008: Brennan Avis R; Dolinsky Beth; Vu Mai-Anh T; Stanley Marion; Yeckel Mark F; Arnsten Amy F T
Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(3):93-6.
2008: Hains Avis B; Arnsten Amy F T
Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(8):551-64.
2008: Brennan Avis R; Arnsten Amy F T
Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function.
Annals of the New York Academy of Sciences 2008;1129():236-45.
2007: Arnsten Amy F T
Catecholamine and second messenger influences on prefrontal cortical networks of "representational knowledge": a rational bridge between genetics and the symptoms of mental illness.
Cerebral cortex (New York, N.Y. : 1991) 2007;17 Suppl 1():i6-15.
2007: Wang Min; Ramos Brian P; Paspalas Constantinos D; Shu Yousheng; Simen Arthur; Duque Alvaro; Vijayraghavan Susheel; Brennan Avis; Dudley Anne; Nou Eric; Mazer James A; McCormick David A; Arnsten Amy F T
Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.
Cell 2007;129(2):397-410.
2007: Ramos Brian P; Arnsten Amy F T
Adrenergic pharmacology and cognition: focus on the prefrontal cortex.
Pharmacology & therapeutics 2007;113(3):523-36.
2007: Vijayraghavan Susheel; Wang Min; Birnbaum Shari G; Williams Graham V; Arnsten Amy F T
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory.
Nature neuroscience 2007;10(3):376-84.
2006: Ramos Brian P; Stark David; Verduzco Luis; van Dyck Christopher H; Arnsten Amy F T
Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals.
Learning & memory (Cold Spring Harbor, N.Y.) 2006;13(6):770-6.
2006: Arnsten Amy F T
Stimulants: Therapeutic actions in ADHD.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(11):2376-83.
2006: Berridge Craig W; Devilbiss David M; Andrzejewski Matthew E; Arnsten Amy F T; Kelley Ann E; Schmeichel Brooke; Hamilton Christina; Spencer Robert C
Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.
Biological psychiatry 2006;60(10):1111-20.
2006: Arnsten A F T; Vijayraghavan S
Staying in touch with methylphenidate: AHDH and sensory processing. Focus on "methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats".
Journal of neurophysiology 2006;96(2):524-5.
2006: Biederman Joseph; Arnsten Amy F T; Faraone Stephen V; Doyle Alysa E; Spencer Thomas J; Wilens Timothy E; Weiss Margaret D; Safren Steven A; Culpepper Larry
New developments in the treatment of ADHD.
The Journal of clinical psychiatry 2006;67(1):148-59.
2006: Arnsten Amy F T
Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways.
The Journal of clinical psychiatry 2006;67 Suppl 8():7-12.
2006: Shansky Rebecca M; Rubinow Katya; Brennan Avis; Arnsten Amy F T
The effects of sex and hormonal status on restraint-stress-induced working memory impairment.
Behavioral and brain functions : BBF 2006;2():8.
2005: Ramos Brian P; Colgan Lesley; Nou Eric; Ovadia Shira; Wilson Steven R; Arnsten Amy F T
The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys.
Biological psychiatry 2005;58(11):894-900.
2005: Arnsten Amy F T; Li Bao-Ming
Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions.
Biological psychiatry 2005;57(11):1377-84.
2005: Arnsten Amy F T; Ramos Brian P; Birnbaum Shari G; Taylor Jane R
Protein kinase A as a therapeutic target for memory disorders: rationale and challenges.
Trends in molecular medicine 2005;11(3):121-8.
2005: Ma Chao-Lin; Arnsten Amy F T; Li Bao-Ming
Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys.
Biological psychiatry 2005;57(2):192-5.
2004: Birnbaum S G; Yuan P X; Wang M; Vijayraghavan S; Bloom A K; Davis D J; Gobeske K T; Sweatt J D; Manji H K; Arnsten A F T
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.
Science (New York, N.Y.) 2004;306(5697):882-4.
2004: Arnsten Amy F T; Shansky Rebecca M
Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IV.
Annals of the New York Academy of Sciences 2004;1021():143-7.
2004: Arnsten Amy F T
Adrenergic targets for the treatment of cognitive deficits in schizophrenia.
Psychopharmacology 2004;174(1):25-31.
2004: Shansky R M; Glavis-Bloom C; Lerman D; McRae P; Benson C; Miller K; Cosand L; Horvath T L; Arnsten A F T
Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction.
Molecular psychiatry 2004;9(5):531-8.
2003: Ramos Brian P; Birnbaum Shari G; Lindenmayer Isabelle; Newton Samuel S; Duman Ronald S; Arnsten Amy F T
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.
Neuron 2003;40(4):835-45.
2003: Lidow Michael S; Koh Phil-Ok; Arnsten Amy F T
D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses.
Synapse (New York, N.Y.) 2003;47(2):101-8.
2002: Franowicz Jenna S; Kessler Lynn E; Borja Catherine M Dailey; Kobilka Brian K; Limbird Lee E; Arnsten Amy F T
Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8771-7.
2002: Franowicz Jenna S; Arnsten Amy F T
Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype.
Psychopharmacology 2002;162(3):304-12.
2000: Birnbaum S G; Podell D M; Arnsten A F
Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats.
Pharmacology, biochemistry, and behavior 2000;67(3):397-403.
2000: Arnsten A F; Murphy B; Merchant K
The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(4):405-10.
2000: Arnsten A F
Genetics of childhood disorders: XVIII. ADHD, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function.
Journal of the American Academy of Child and Adolescent Psychiatry 2000;39(9):1201-3.
2000: Avery R A; Franowicz J S; Studholme C; van Dyck C H; Arnsten A F
The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(3):240-9.
2000: Macy J D; Beattie T A; Morgenstern S E; Arnsten A F
Use of guanfacine to control self-injurious behavior in two rhesus macaques (Macaca mulatta) and one baboon (Papio anubis).
Comparative medicine 2000;50(4):419-25.
2000: Arnsten A F
Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms.
Progress in brain research 2000;126():183-92.
2000: Arnsten A F
Through the looking glass: differential noradenergic modulation of prefrontal cortical function.
Neural plasticity 2000;7(1-2):133-46.
1999: Birnbaum S; Gobeske K T; Auerbach J; Taylor J R; Arnsten A F
A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex.
Biological psychiatry 1999;46(9):1266-74.
1999: Mao Z M; Arnsten A F; Li B M
Local infusion of an alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys.
Biological psychiatry 1999;46(9):1259-65.
1999: Southwick S M; Bremner J D; Rasmusson A; Morgan C A; Arnsten A; Charney D S
Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder.
Biological psychiatry 1999;46(9):1192-204.
1999: Franowicz J S; Arnsten A F
Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(5):611-21.
1999: Taylor J R; Birnbaum S; Ubriani R; Arnsten A F
Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(18):RC23.
1999: Arnsten A F
Development of the cerebral cortex: XIV. Stress impairs prefrontal cortical function.
Journal of the American Academy of Child and Adolescent Psychiatry 1999;38(2):220-2.
1999: Mao Z M; Li B M; Arnsten A F
[Roles of alpha-2 adrenoceptor in prefrontal cortical cognitive functions]
Sheng li ke xue jin zhan [Progress in physiology] 1999;30(1):17-22.
1999: Arnsten A F; Mathew R; Ubriani R; Taylor J R; Li B M
Alpha-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function.
Biological psychiatry 1999;45(1):26-31.
1998: Arnsten A F
The biology of being frazzled.
Science (New York, N.Y.) 1998;280(5370):1711-2.
1998: Arnsten A F; Goldman-Rakic P S
Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism.
Archives of general psychiatry 1998;55(4):362-8.
1998: Franowicz J S; Arnsten A F
The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys.
Psychopharmacology 1998;136(1):8-14.
1998: Arnsten A F; Steere J C; Jentsch D J; Li B M
Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors.
Advances in pharmacology (San Diego, Calif.) 1998;42():764-7.
1997: Zahrt J; Taylor J R; Mathew R G; Arnsten A F
Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8528-35.
1997: Steere J C; Arnsten A F
The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.
Behavioral neuroscience 1997;111(5):883-91.
1997: Cai J X; Arnsten A F
Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.
The Journal of pharmacology and experimental therapeutics 1997;283(1):183-9.
1997: Arnsten A F; Jentsch J D
The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys.
Pharmacology, biochemistry, and behavior 1997;58(1):55-9.
1997: van Dyck C H; Lin C H; Robinson R; Cellar J; Smith E O; Nelson J C; Arnsten A F; Hoffer P B
The acetylcholine releaser linopirdine increases parietal regional cerebral blood flow in Alzheimer's disease.
Psychopharmacology 1997;132(3):217-26.
1997: Murphy B L; Roth R H; Arnsten A F
Clozapine reverses the spatial working memory deficits induced by FG7142 in monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(6):433-7.
1997: Arnsten A F; Lin C H; Van Dyck C H; Stanhope K J
The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys.
Neurobiology of aging 1997;18(1):21-8.
1997: Arnsten A F
Catecholamine regulation of the prefrontal cortex.
Journal of psychopharmacology (Oxford, England) 1997;11(2):151-62.
1996: Murphy B L; Arnsten A F; Jentsch J D; Roth R H
Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7768-75.
1996: Arnsten A F; Steere J C; Hunt R D
The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder.
Archives of general psychiatry 1996;53(5):448-55.
1996: Murphy B L; Arnsten A F; Goldman-Rakic P S; Roth R H
Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1325-9.
1995: Chappell P B; Riddle M A; Scahill L; Lynch K A; Schultz R; Arnsten A; Leckman J F; Cohen D J
Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience.
Journal of the American Academy of Child and Adolescent Psychiatry 1995;34(9):1140-6.
1995: Steere J C; Arnsten A F
Corpus callosum morphology in ADHD.
The American journal of psychiatry 1995;152(7):1105-6.
1995: Arnsten A F; Cai J X; Steere J C; Goldman-Rakic P S
Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3429-39.
1995: Hunt R D; Arnsten A F; Asbell M D
An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder.
Journal of the American Academy of Child and Adolescent Psychiatry 1995;34(1):50-4.
1994: Arnsten A F; Cai J X; Murphy B L; Goldman-Rakic P S
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys.
Psychopharmacology 1994;116(2):143-51.
1993: Arnsten A F
Catecholamine mechanisms in age-related cognitive decline.
Neurobiology of aging 1993;14(6):639-41.
1993: Arnsten A F; Cai J X
Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine.
Neurobiology of aging 1993;14(6):597-603.
1992: Arnsten A F; Contant T A
Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task.
Psychopharmacology 1992;108(1-2):159-69.
1991: Arnsten A F; Leslie F M
Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.
Neuropharmacology 1991;30(12A):1279-89.
1990: Arnsten A F; Goldman-Rakic P S
Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys.
Neurobiology of aging 1990;11(6):583-90.
1988: Arnsten A F; Cai J X; Goldman-Rakic P S
The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(11):4287-98.
1987: Arnsten A F; Goldman-Rakic P S
Noradrenergic mechanisms in age-related cognitive decline.
Journal of neural transmission. Supplementum 1987;24():317-24.

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