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Jemy Gutierrez

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Chemicals & Drugs

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Keith Clinch; Gary B Evans; Richard F G Fröhlich; Shivali A Gulab; Jemy A Gutierrez; Jennifer M Mason; Vern L Schramm; Peter C Tyler; Anthony D Woolhouse
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.
Ivan Hemeon; Meng-Chiao Ho; Jemy A Gutierrez; Vern L Schramm
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.
Maria Cassera; Richard DePinto; Gary B Evans; Jemy A Gutierrez; Keith Z Hazleton; Meng-Chiao Ho; Emilio F Merino; Andrew S Murkin; Nicanor Obaldia; Steven C Almo; Yarlagadda S Babu; Vern L Schramm
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.

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All Publications

2012: Keith Clinch; Gary B Evans; Richard F G Fröhlich; Shivali A Gulab; Jemy A Gutierrez; Jennifer M Mason; Vern L Schramm; Peter C Tyler; Anthony D Woolhouse
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.
Bioorganic & medicinal chemistry 2012;20(17):5181-7.
2011: Ivan Hemeon; Meng-Chiao Ho; Jemy A Gutierrez; Vern L Schramm
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay.
Analytical chemistry 2011;83(12):4996-5004.
2011: Maria Cassera; Richard DePinto; Gary B Evans; Jemy A Gutierrez; Keith Z Hazleton; Meng-Chiao Ho; Emilio F Merino; Andrew S Murkin; Nicanor Obaldia; Steven C Almo; Yarlagadda S Babu; Vern L Schramm
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.
PloS one 2011;6(11):e26916.
2010: Megan E Meyer; Jemy A Gutierrez; Frank M Raushel; Nigel G J Richards
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase.
Biochemistry 2010;49(43):9391-401.
2010: Alistair I Longshaw; Florian Adanitsch; Jemy A Gutierrez; Gary B Evans; Peter C Tyler; Vern L Schramm
Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase.
Journal of medicinal chemistry 2010;53(18):6730-46.
2009: Jemy A Gutierrez; Tamara Crowder; Agnes Rinaldo-Matthis; Meng-Chiao Ho; Steven C Almo; Vern L Schramm
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Nature chemical biology 2009;5(4):251-7.
2008: Vern L Schramm; Jemy A Gutierrez; Grace Cordovano; Indranil Basu; Chandan Guha; Thomas J Belbin; Gary B Evans; Peter C Tyler; Richard H Furneaux
Transition state analogues in quorum sensing and SAM recycling.
Nucleic acids symposium series (2004) 2008;(52):75-6.
2007: Jemy A Gutierrez; Minkui Luo; Vipender Singh; Lei Li; Rosemary L Brown; Gillian E Norris; Gary B Evans; Richard H Furneaux; Peter C Tyler; Gavin F Painter; Dirk H Lenz; Vern L Schramm
Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.
ACS chemical biology 2007;2(11):725-34.
2006: Jemy A Gutierrez; Yuan-Xiang Pan; Lukasz Koroniak; Jun Hiratake; Michael S Kilberg; Nigel G J Richards
An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.
Chemistry & biology 2006;13(12):1339-47.
2005: Mihai Ciustea; Jemy A Gutierrez; Susan E Abbatiello; John R Eyler; Nigel G J Richards
Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase.
Archives of biochemistry and biophysics 2005;440(1):18-27.
2003: Lukasz Koroniak; Mihai Ciustea; Jemy A Gutierrez; Nigel G J Richards
Synthesis and characterization of an N-acylsulfonamide inhibitor of human asparagine synthetase.
Organic letters 2003;5(12):2033-6.