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José María Gutiérrez

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Lethal Dose 50

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José María Gutiérrez; Bruno Lomonte; Davinia Pla; Libia Sanz; Gabriela Solano; Wan-Chih Tsai; Yamileth Angulo; Juan J Calvete
Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays.
Alvaro Segura; Mariángela Vargas; Mauren Villalta; José María Gutiérrez; María Herrera; Guillermo León
Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.
Arley Camilo Patiño; Jaime Andrés Pereañez; José María Gutiérrez; Alexandra Rucavado
Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom.

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2013: José María Gutiérrez; Bruno Lomonte; Davinia Pla; Libia Sanz; Gabriela Solano; Wan-Chih Tsai; Yamileth Angulo; Juan J Calvete
Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays.
Toxicon : official journal of the International Society on Toxinology 2013;64():60-9.
2013: Alvaro Segura; Mariángela Vargas; Mauren Villalta; José María Gutiérrez; María Herrera; Guillermo León
Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.
Biologicals : journal of the International Association of Biological Standardization 2013;41(2):93-7.
2013: Arley Camilo Patiño; Jaime Andrés Pereañez; José María Gutiérrez; Alexandra Rucavado
Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom.
Toxicon : official journal of the International Society on Toxinology 2013;63():32-43.
2013: Cristina Herrera; Alexandra Rucavado; David A Warrell; José María Gutiérrez
Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model.
Toxicon : official journal of the International Society on Toxinology 2013;63():19-31.
2013: José María Gutiérrez; Bruno Lomonte
Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins.
Toxicon : official journal of the International Society on Toxinology 2013;62():27-39.
2012: Cristiane Bregge-Silva; Sérgio de Albuquerque; Cecilia Díaz; José María Gutiérrez; Paulo Lee Ho; Inácio L M Junqueira de Azevedo; Bruno Lomonte; Maria Cristina Nonato; Alexandra Rucavado; Marcelo Ribeiro Vasconcelos Diniz; Eliane C Arantes
Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom.
Toxicon : official journal of the International Society on Toxinology 2012;60(7):1263-76.
2012: Juan Carlos Quintana; C Segura; L Vargas; A M Chacón; José María Gutiérrez; J C Alarcón
Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B.
Acta tropica 2012;124(2):126-32.
2012: Mauren Villalta; Su Lin Yang; María Herrera; Cheng Dow Lee; Guillermo León; Davinia Pla; Libia Sanz; Alvaro Segura; Mariángela Vargas; Yamileth Angulo; Juan J Calvete; Maykel Cerdas; Pei Yu Chen; Ya Fen Cheng; Jen Ron Chiang; Ricardo Estrada; José María Gutiérrez
Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: keys to understand the variable immune response in horses.
Journal of proteomics 2012;75(18):5628-45.
2012: José María Gutiérrez
Improving antivenom availability and accessibility: science, technology, and beyond.
Toxicon : official journal of the International Society on Toxinology 2012;60(4):676-87.
2012: Mariángela Vargas; Mauren Villalta; Yamileth Angulo; José María Gutiérrez; María Herrera; Guillermo León; Alvaro Segura; Thierry Burnouf
Purification of IgG and albumin from human plasma by aqueous two phase system fractionation.
Biotechnology progress 2012;28(4):1005-11.
2012: María Herrera; Simon D Jensen; Guillermo León; Teatulohi Matainaho; Owen Paiva; Mariángela Vargas; Mauren Villalta; David J Williams; Kenneth D Winkel; Álvaro Segura; Yamileth Angulo; Juan J Calvete; Julián Fernández; José María Gutiérrez
Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity.
Journal of proteomics 2012;75(7):2128-40.
2012: Bruno Lomonte; Gabriela Solano; Alejandro Solórzano; Wan-Chih Tsai; Yamileth Angulo; Fabián Bonilla; José María Gutiérrez; Juan J Calvete
Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.
Toxicon : official journal of the International Society on Toxinology 2012;59(5):592-9.
2012: Bruno Lomonte; Paola Rey-Suárez; Mahmood Sasa; Wan-Chih Tsai; Yamileth Angulo; José María Gutiérrez; Juan J Calvete
Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: toxicological and taxonomical insights.
Journal of proteomics 2012;75(5):1675-89.
2012: Rafael Otero-Patiño; Monica Perea; Andrés Pereañez; Lady Pupo; Juan Carlos Quintana; C Eugenio Ramírez; Patricia Ramírez; Alcides Rivero; Alvaro Segura; Ana María Suárez; Leidy J Vargas; Yamileth Angulo; Ana Berta Arrieta; Yobana Arroyo; Jacqueline Barona; Dalila Betancur; Nectty Lorena Conrado; Elkin A Córdoba; Abel Díaz; Sebastián Estrada; Patricia Fabra; Diego Fernández; Jorge Fernández; Juan Pablo Gómez; José María Gutiérrez; María Herrera; Guillermo León; Diana Carolina Mosquera; Rosina Ortiz
Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia.
Toxicon : official journal of the International Society on Toxinology 2012;59(2):344-55.
2011: Paola Rey-Suárez; Vitelbina Núñez; José María Gutiérrez; Bruno Lomonte
Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica.
Journal of proteomics 2011;75(2):655-67.
2011: Ileana Méndez; Yamileth Angulo; Juan J Calvete; José María Gutiérrez; Bruno Lomonte
Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom.
Toxicon : official journal of the International Society on Toxinology 2011;58(6-7):558-64.
2011: Guillermo León; Laura Sánchez; Alvaro Segura; Mauren Villalta; Ricardo Estrada; Andrés Hernández; María Herrera; José María Gutiérrez
Immune response towards snake venoms.
Inflammation & allergy drug targets 2011;10(5):381-98.
2011: José María Gutiérrez; Guillermo León; Bruno Lomonte; Yamileth Angulo
Antivenoms for snakebite envenomings.
Inflammation & allergy drug targets 2011;10(5):369-80.
2011: Teresa Escalante; Jay W Fox; Alexandra Rucavado; José María Gutiérrez
Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases.
Journal of proteomics 2011;74(9):1781-94.
2011: José Rangel; Orestes Quesada; Yamileth Angulo; José María Gutiérrez; Bruno Lomonte
Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper.
Cell biochemistry and function 2011;29(5):365-70.
2011: Mariángela Vargas; Alvaro Segura; María Herrera; Mauren Villalta; Ricardo Estrada; Maykel Cerdas; Owen Paiva; Teatulohi Matainaho; Simon D Jensen; Kenneth D Winkel; Guillermo León; José María Gutiérrez; David J Williams
Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea.
PLoS neglected tropical diseases 2011;5(5):e1144.
2011: José María Gutiérrez; Guillermo León; Thierry Burnouf
Antivenoms for the treatment of snakebite envenomings: the road ahead.
Biologicals : journal of the International Association of Biological Standardization 2011;39(3):129-42.
2011: Alexandra Rucavado; Teresa Escalante; John Shannon; José María Gutiérrez; Jay W Fox
Proteomics of wound exudate in snake venom-induced pathology: search for biomarkers to assess tissue damage and therapeutic success.
Journal of proteome research 2011;10(4):1987-2005.
2011: Julián Fernández; Alberto Alape-Girón; Yamileth Angulo; Libia Sanz; José María Gutiérrez; Juan J Calvete; Bruno Lomonte
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).
Journal of proteome research 2011;10(4):1816-27.
2011: Juan J Calvete; Libia Sanz; Alicia Pérez; Adolfo Borges; Alba M Vargas; Bruno Lomonte; Yamileth Angulo; José María Gutiérrez; Hipócrates M Chalkidis; Rosa H V Mourão; M Fatima D Furtado; Ana M Moura-Da-Silva
Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management.
Journal of proteomics 2011;74(4):510-27.
2011: Vanessa Moreira; José María Gutiérrez; Rafaela Bacci Amaral; Bruno Lomonte; Eduardo Purgatto; Catarina Teixeira
A phospholipase A₂ from Bothrops asper snake venom activates neutrophils in culture: expression of cyclooxygenase-2 and PGE₂ biosynthesis.
Toxicon : official journal of the International Society on Toxinology 2011;57(2):288-96.
2010: José María Gutiérrez; David Williams; Hui Wen Fan; David A Warrell
Snakebite envenoming from a global perspective: Towards an integrated approach.
Toxicon : official journal of the International Society on Toxinology 2010;56(7):1223-35.
2010: Ricardo Estrada; María Herrera; Alvaro Segura; Javier Araya; Carlos Boschini; José María Gutiérrez; Guillermo León
Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows.
Biologicals : journal of the International Association of Biological Standardization 2010;38(6):664-9.
2010: A Segura; M C Castillo; Vitelbina Núñez; A Yarlequé; L R C Gonçalves; M Villalta; C Bonilla; M Herrera; Maribel Vargas; M Fernández; M Y Yano; H P Araújo; M A A Boller; P León; B Tintaya; I S Sano-Martins; A Gómez; G P Fernández; P Geoghegan; Hisako Gondo Higashi; Guillermo León; José María Gutiérrez
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms.
Toxicon : official journal of the International Society on Toxinology 2010;56(6):980-9.
2010: Gabriela Solano; Alvaro Segura; María Herrera; Aarón Gómez; Mauren Villalta; José María Gutiérrez; Guillermo León
Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom.
Biologicals : journal of the International Association of Biological Standardization 2010;38(5):577-85.
2010: Julián Fernández; Bruno Lomonte; Libia Sanz; Yamileth Angulo; José María Gutiérrez; Juan J Calvete
Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose.
Journal of proteome research 2010;9(8):4234-41.
2010: Hannes G Wallnoefer; Torsten Lingott; José María Gutiérrez; Irmgard Merfort; Klaus Liedl
Backbone flexibility controls the activity and specificity of a protein-protein interface: specificity in snake venom metalloproteases.
Journal of the American Chemical Society 2010;132(30):10330-7.
2010: Juan J Calvete; Pedro Cid; Libia Sanz; Alvaro Segura; Mauren Villalta; María Herrera; Guillermo León; Robert Harrison; Nandul Durfa; Abdulsalami Nasidi; R David G Theakston; David A Warrell; José María Gutiérrez
Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.
The American journal of tropical medicine and hygiene 2010;82(6):1194-201.
2010: Julián Fernández; José María Gutiérrez; Yamileth Angulo; Libia Sanz; Paula Juárez; Juan J Calvete; Bruno Lomonte
Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization.
Biochimie 2010;92(3):273-83.
2010: Alvaro Segura; Mauren Villalta; María Herrera; Guillermo León; Robert Harrison; Nandul Durfa; Abdulsalami Nasidi; Juan J Calvete; R David G Theakston; David A Warrell; José María Gutiérrez
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa.
Toxicon : official journal of the International Society on Toxinology 2010;55(2-3):369-74.
2010: José María Gutiérrez; Libia Sanz; Marietta Flores-Díaz; Lucía Figueroa; Marvin Madrigal; María Herrera; Mauren Villalta; Guillermo León; Ricardo Estrada; Adolfo Borges; Alberto Alape-Girón; Juan J Calvete
Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: integrating antivenomics and neutralization approaches.
Journal of proteome research 2010;9(1):564-77.
2010: Juan J Calvete; Libia Sanz; Pedro Cid; Pilar de la Torre; Marietta Flores-Díaz; M Cristina Dos Santos; Adolfo Borges; Adolfo Bremo; Yamileth Angulo; Bruno Lomonte; Alberto Alape-Girón; José María Gutiérrez
Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.
Journal of proteome research 2010;9(1):528-44.
2010: José María Gutiérrez; Alexandra Rucavado; Teresa Escalante; Bruno Lomonte; Yamileth Angulo; Jay W Fox
Tissue pathology induced by snake venoms: how to understand a complex pattern of alterations from a systems biology perspective?
Toxicon : official journal of the International Society on Toxinology 2010;55(1):166-70.
2009: José María Gutiérrez
Bothrops asper: beauty and peril in the neotropics.
Toxicon : official journal of the International Society on Toxinology 2009;54(7):901-3.
2009: José María Gutiérrez; Teresa Escalante; Alexandra Rucavado
Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.
Toxicon : official journal of the International Society on Toxinology 2009;54(7):976-87.
2009: José María Gutiérrez; Alexandra Rucavado; Fernando Chaves; Cecilia Díaz; Teresa Escalante
Experimental pathology of local tissue damage induced by Bothrops asper snake venom.
Toxicon : official journal of the International Society on Toxinology 2009;54(7):958-75.
2009: Vitelbina Núñez; Pedro Cid; Libia Sanz; Pilar De La Torre; Yamileth Angulo; Bruno Lomonte; José María Gutiérrez; Juan J Calvete
Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.
Journal of proteomics 2009;73(1):57-78.
2009: Teresa Escalante; Alexandra Rucavado; Antonio F M Pinto; Renata M S Terra; José María Gutiérrez; Jay W Fox
Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins.
Journal of proteome research 2009;8(11):5120-31.
2009: María Herrera; Fabricio Meneses; José María Gutiérrez; Guillermo León
Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production.
Biologicals : journal of the International Association of Biological Standardization 2009;37(4):230-4.
2009: Juan J Calvete; Libia Sanz; Yamileth Angulo; Bruno Lomonte; José María Gutiérrez
Venoms, venomics, antivenomics.
FEBS letters 2009;583(11):1736-43.
2009: José María Gutiérrez; Hui Wen Fan; Carmen L M Silvera; Yamileth Angulo
Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop.
Toxicon : official journal of the International Society on Toxinology 2009;53(6):625-30.
2009: Alvaro Segura; María Herrera; Esteban González; Mariángela Vargas; Gabriela Solano; José María Gutiérrez; Guillermo León
Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature.
Toxicon : official journal of the International Society on Toxinology 2009;53(6):609-15.
2009: Juan J Calvete; Adolfo Borges; Alvaro Segura; Marietta Flores-Díaz; Alberto Alape-Girón; José María Gutiérrez; Nardy Diez; Leonardo De Sousa; Demetrio Kiriakos; Eladio Sánchez; José G Faks; JOSÉ ESCOLANO; Libia Sanz
Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.
Journal of proteomics 2009;72(2):227-40.
2009: José María Gutiérrez; Bruno Lomonte; Guillermo León; Alberto Alape-Girón; Marietta Flores-Díaz; Libia Sanz; Yamileth Angulo; Juan J Calvete
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.
Journal of proteomics 2009;72(2):165-82.
2009: Vanessa Moreira; José María Gutiérrez; Rafaela Bacci Amaral; Stella Regina Zamunér; Catarina de Fátima Pereira Teixeira
Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro.
Prostaglandins, leukotrienes, and essential fatty acids 2009;80(2-3):107-14.
2009: Bruno Lomonte; Yamileth Angulo; Mahmood Sasa; José María Gutiérrez
The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles.
Protein and peptide letters 2009;16(8):860-76.
2008: Alexandra Rucavado; Mónica Henríquez; Jonielle García; José María Gutiérrez
Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom.
Toxicon : official journal of the International Society on Toxinology 2008;52(7):754-9.
2008: Guillermo León; Alvaro Segura; María Herrera; Rafael Otero; Francisco Oscar de Siqueira França; Katia Cristina Barbaro; João Luiz Costa Cardoso; Fan Hui Wen; Carlos Roberto de Medeiros; José Carlos Lopes Prado; Ceila María Sant'Ana Malaque; Bruno Lomonte; José María Gutiérrez
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102(11):1115-9.
2008: José María Gutiérrez; Libia Sanz; JOSÉ ESCOLANO; Julián Fernández; Bruno Lomonte; Yamileth Angulo; Alexandra Rucavado; David A Warrell; Juan J Calvete
Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom.
Journal of proteome research 2008;7(10):4396-408.
2008: Natalia Jiménez; Teresa Escalante; José María Gutiérrez; Alexandra Rucavado
Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model.
The Journal of investigative dermatology 2008;128(10):2421-8.
2008: Pablo Fernández; José María Gutiérrez
Mortality due to snakebite envenomation in Costa Rica (1993-2006).
Toxicon : official journal of the International Society on Toxinology 2008;52(3):530-3.
2008: Vanessa Moreira; José María Gutiérrez; Andreimar Martins Soares; Stella Regina Zamunér; Eduardo Purgatto; Catarina de Fátima Pereira Teixeira
Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases.
Toxicon : official journal of the International Society on Toxinology 2008;52(3):428-39.
2008: C Montecucco; José María Gutiérrez; Bruno Lomonte
Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action.
Cellular and molecular life sciences : CMLS 2008;65(18):2897-912.
2008: Bruno Lomonte; JOSÉ ESCOLANO; Julián Fernández; Libia Sanz; Yamileth Angulo; José María Gutiérrez; Juan J Calvete
Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii.
Journal of proteome research 2008;7(6):2445-57.
2008: Yamileth Angulo; JOSÉ ESCOLANO; Bruno Lomonte; José María Gutiérrez; Libia Sanz; Juan J Calvete
Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi.
Journal of proteome research 2008;7(2):708-19.
2008: Javier Mora; Rodrigo Mora; Bruno Lomonte; José María Gutiérrez
Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation.
PLoS neglected tropical diseases 2008;2(10):e318.
2008: A V Pérez; Alexandra Rucavado; L Sanz; J J Calvete; José María Gutiérrez
Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2008;41(1):12-7.
2008: José María Gutiérrez; Luis Alberto Ponce-Soto; Sérgio Marangoni; Bruno Lomonte
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue.
Toxicon : official journal of the International Society on Toxinology 2008;51(1):80-92.
2007: Juan Carlos Villalobos; Rodrigo Mora; Bruno Lomonte; José María Gutiérrez; Yamileth Angulo
Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(8):1382-9.
2007: Guillermo León; Miguel Angel Rodríguez; Alexandra Rucavado; Bruno Lomonte; José María Gutiérrez
Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations.
Biologicals : journal of the International Association of Biological Standardization 2007;35(1):5-11.
2007: José María Gutiérrez; Bruno Lomonte; Guillermo León; Alexandra Rucavado; Fernando Chaves; Yamileth Angulo
Trends in snakebite envenomation therapy: scientific, technological and public health considerations.
Current pharmaceutical design 2007;13(28):2935-50.
2007: José María Gutiérrez; Hisako Gondo Higashi; Fan Hui Wen; Thierry Burnouf
Strengthening antivenom production in Central and South American public laboratories: report of a workshop.
Toxicon : official journal of the International Society on Toxinology 2007;49(1):30-5.
2006: Rafael Otero; Guillermo León; José María Gutiérrez; Gustavo Rojas; María Fabiola Toro; Jacqueline Barona; Verónica Rodríguez; Abel Díaz; Vitelbina Núñez; Juan Carlos Quintana; Shirley Ayala; Diana Mosquera; Lesdy L Conrado; Diego Fernández; Yobana Arroyo; Carlos A Paniagua; Mercedes López; Carlos E Ospina; Claudia Alzate; Jorge Fernández; Jazmín J Meza; Juan F Silva; Patricia Ramírez; Patricia E Fabra; Eugenio Ramírez; Elkin Córdoba; Ana B Arrieta; David A Warrell; R David G Theakston
Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(12):1173-82.
2006: Teresa Escalante; John Shannon; Ana Maria Moura da Silva; José María Gutiérrez; Jay W Fox
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study.
Archives of biochemistry and biophysics 2006;455(2):144-53.
2006: Lil Quesada; Carlos Sevcik; Bruno Lomonte; Ermila Rojas; José María Gutiérrez
Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbits.
Toxicon : official journal of the International Society on Toxinology 2006;48(3):255-63.
2006: Fernando Chaves; Catarina F P Teixeira; José María Gutiérrez
Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55(6):245-53.
2006: José María Gutiérrez; R David G Theakston; David A Warrell
Confronting the neglected problem of snake bite envenoming: the need for a global partnership.
PLoS medicine 2006;3(6):e150.
2006: Cristina Maria Fernandes; Stella R Zamuner; Juliana Pavan Zuliani; Alexandra Rucavado; José María Gutiérrez; Catarina de Fátima Pereira Teixeira
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines.
Toxicon : official journal of the International Society on Toxinology 2006;47(5):549-59.
2006: José María Gutiérrez; Javier Núñez; Teresa Escalante; Alexandra Rucavado
Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase.
Microvascular research 2006;71(1):55-63.
2006: Rodrigo Mora; Alexis Maldonado; Berta Valverde; José María Gutiérrez
Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line.
Toxicon : official journal of the International Society on Toxinology 2006;47(1):75-86.
2005: Stella R Zamuner; Juliana Pavan Zuliani; Cristina Maria Fernandes; José María Gutiérrez; Catarina de Fátima Pereira Teixeira
Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration.
Toxicon : official journal of the International Society on Toxinology 2005;46(7):806-13.
2005: María Herrera; Guillermo León; Alvaro Segura; Fabricio Meneses; Bruno Lomonte; Jean-Philippe Chippaux; José María Gutiérrez
Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs.
Toxicon : official journal of the International Society on Toxinology 2005;46(7):775-81.
2005: Juliana Pavan Zuliani; José María Gutiérrez; Luciana Lyra Casais e Silva; Sandra Coccuzzo Sampaio; Bruno Lomonte; Catarina de Fátima Pereira Teixeira
Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A(2).
Toxicon : official journal of the International Society on Toxinology 2005;46(5):523-32.
2005: Paul Gallagher; Yongde Bao; Solange M T Serrano; Gavin D Laing; R David G Theakston; José María Gutiérrez; Teresa Escalante; Paola Zigrino; Ana Maria Moura da Silva; Roswitha Nischt; Cornelia Mauch; Christopher A Moskaluk; Jay W Fox
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin.
Archives of biochemistry and biophysics 2005;441(1):1-15.
2005: Yamileth Angulo; José María Gutiérrez; Andreimar M Soares; Wonhwa Cho; Bruno Lomonte
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation.
Toxicon : official journal of the International Society on Toxinology 2005;46(3):291-6.
2005: Alexandra Rucavado; Mónica Soto; Teresa Escalante; Gilbert D Loría; Raghuvir K Arni; José María Gutiérrez
Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.
Thrombosis and haemostasis 2005;94(1):123-31.
2005: José María Gutiérrez; Alexandra Rucavado; Teresa Escalante; Cecilia Díaz
Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage.
Toxicon : official journal of the International Society on Toxinology 2005;45(8):997-1011.
2005: José María Gutiérrez; Ermila Rojas; Lil Quesada; Guillermo León; J Núñez; Gavin D Laing; M Sasa; Juan M Renjifo; A Nasidi; David A Warrell; R David G Theakston; Gustavo Rojas
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(6):468-75.
2005: Catarina F P Teixeira; Fernando Chaves; Stella R Zamunér; Cristina Maria Fernandes; Juliana Pavan Zuliani; María Alice Cruz-Hofling; Irene Fernandes; José María Gutiérrez
Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom.
International journal of experimental pathology 2005;86(2):107-15.
2005: Rodrigo Mora; Berta Valverde; Cecilia Díaz; Bruno Lomonte; José María Gutiérrez
A Lys49 phospholipase A(2) homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line.
Toxicon : official journal of the International Society on Toxinology 2005;45(5):651-60.
2005: Juliana Pavan Zuliani; Cristina Maria Fernandes; Stella R Zamuner; José María Gutiérrez; Catarina F P Teixeira
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity.
Toxicon : official journal of the International Society on Toxinology 2005;45(3):335-46.
2005: Cecilia Díaz; Lorena Valverde; Oscar Brenes; Alexandra Rucavado; José María Gutiérrez
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells.
Journal of cellular biochemistry 2005;94(3):520-8.
2005: Fernando Chaves; Catarina F P Teixeira; José María Gutiérrez
Role of TNF-alpha, IL-1beta and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice.
Toxicon : official journal of the International Society on Toxinology 2005;45(2):171-8.
2005: Ermila Rojas; Lil Quesada; Viviana Arce; Bruno Lomonte; Gustavo Rojas; José María Gutiérrez
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment.
Acta tropica 2005;93(1):85-95.
2005: Guillermo León; Bruno Lomonte; José María Gutiérrez
Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols.
Toxicon : official journal of the International Society on Toxinology 2005;45(1):123-8.
2004: Marucia Chacur; José María Gutiérrez; Erin D Milligan; Julie Wieseler Frank; Luiz R G Britto; Steven F Maier; Linda R Watkins; Yara Cury
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
Pain 2004;111(1-2):65-76.
2004: Aldo H Urdaneta; Federico Bolaños; José María Gutiérrez
Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2004;138(4):485-92.
2004: Vitelbina Núñez; Viviana Arce; José María Gutiérrez; Bruno Lomonte
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox.
Toxicon : official journal of the International Society on Toxinology 2004;44(1):91-101.
2004: Alexandra Rucavado; Teresa Escalante; José María Gutiérrez
Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation.
Toxicon : official journal of the International Society on Toxinology 2004;43(4):417-24.
2004: Marucia Chacur; Erin D Milligan; Evan M Sloan; Julie Wieseler Frank; Ruth M Barrientos; David Martin; Stephen Poole; Brono Lomonte; José María Gutiérrez; Steven F Maier; Yara Cury; Linda R Watkins
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Pain 2004;108(1-2):180-91.
2004: Teresa Escalante; Alexandra Rucavado; Aura S Kamiguti; R David G Theakston; José María Gutiérrez
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.
Toxicon : official journal of the International Society on Toxinology 2004;43(2):213-7.
2003: José María Gutiérrez; Charlotte L Ownby
Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity.
Toxicon : official journal of the International Society on Toxinology 2003;42(8):915-31.
2003: Teresa Escalante; Javier Núñez; Ana Maria Moura da Silva; Alexandra Rucavado; R David G Theakston; José María Gutiérrez
Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom.
Toxicology and applied pharmacology 2003;193(1):17-28.
2003: Catarina F P Teixeira; Stella R Zamunér; Juliana Pavan Zuliani; Cristina Maria Fernandes; M A Cruz-Hofling; I Fernandes; Fernando Chaves; José María Gutiérrez
Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom.
Muscle & nerve 2003;28(4):449-59.
2003: Leandra Watanabe; John D Shannon; Richard H Valente; Alexandra Rucavado; Alberto Alape-Girón; Aura S Kamiguti; R David G Theakston; Jay W Fox; José María Gutiérrez; Raghuvir K Arni
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.
Protein science : a publication of the Protein Society 2003;12(10):2273-81.
2003: Gilbert D Loría; Alexandra Rucavado; Aura S Kamiguti; R David G Theakston; Jay W Fox; Alberto Alape; José María Gutiérrez
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.
Archives of biochemistry and biophysics 2003;418(1):13-24.
2003: Mónica María Saldarriaga; Rafael Otero; Vitelbina Núñez; María Fabiola Toro; Abel Díaz; José María Gutiérrez
Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia.
Toxicon : official journal of the International Society on Toxinology 2003;42(4):405-11.
2003: Viviana Arce; Ermila Rojas; Charlotte L Ownby; Gustavo Rojas; José María Gutiérrez
Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes.
Toxicon : official journal of the International Society on Toxinology 2003;41(7):851-60.
2003: Marucia Chacur; Ingrid Longo; Gisele Picolo; José María Gutiérrez; B Lomonte; José Luiz Guerra; Catarina F P Teixeira; Yara Cury
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.
Toxicon : official journal of the International Society on Toxinology 2003;41(6):667-78.
2003: Fernando Chaves; Gilbert D Loría; Adriana Salazar; José María Gutiérrez
Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG.
Toxicon : official journal of the International Society on Toxinology 2003;41(2):237-44.
2003: José María Gutiérrez; Guillermo León; Bruno Lomonte
Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.
Clinical pharmacokinetics 2003;42(8):721-41.
2002: Gisele Picolo; Marucia Chacur; José María Gutiérrez; Catarina F P Teixeira; Yara Cury
Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2002;35(10):1221-8.
2002: José María Gutiérrez
[Biomedical research in Revista de Biologia Tropical].
Revista de biología tropical 2002;50(3-4):941-9.
2002: Mônica Lopes-Ferreira; Ana Maria Moura da Silva; Ana Amélia Piran-Soares; Yamileth Angulo; Bruno Lomonte; José María Gutiérrez; Sandra H P Farsky
Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment.
Toxicon : official journal of the International Society on Toxinology 2002;40(8):1141-147.
2002: José María Gutiérrez
[Understanding snake venoms: 50 years of research in Latin America].
Revista de biología tropical 2002;50(2):377-94.
2002: Mildred García; María Monge; Guillermo León; Sergio Lizano; Eduardo Segura; Gabriela Solano; Gustavo Rojas; José María Gutiérrez
Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation.
Biologicals : journal of the International Association of Biological Standardization 2002;30(2):143-51.
2002: Leandra Watanabe; Alexandra Rucavado; Aura S Kamiguti; R David G Theakston; José María Gutiérrez; Raghuvir K Arni
Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1034-5.
2002: Alexandra Rucavado; Teresa Escalante; Catarina F P Teixeira; Cristina María Fernándes; Cecilia Diaz; José María Gutiérrez
Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.
Mediators of inflammation 2002;11(2):121-8.
2002: Patricia Saravia; Ermila Rojas; Viviana Arce; Corina Guevara; Juan Carlos López; Esteban Chaves; Rubén Velásquez; Gustavo Rojas; José María Gutiérrez
Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications.
Revista de biología tropical 2002;50(1):337-46.
2001: María L Avila-Agüero; María M París; S Hu; P K Peterson; José María Gutiérrez; Bruno Lomonte; Idis Faingezicht
Systemic cytokine response in children bitten by snakes in Costa Rica.
Pediatric emergency care 2001;17(6):425-9.
2001: Stella R Zamuner; José María Gutiérrez; Marcelo N Muscará; Simone A Teixeira; Catarina F P Teixeira
Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.
Toxicon : official journal of the International Society on Toxinology 2001;39(10):1505-13.
2001: Andreimar M Soares; Adriana C Mancin; Alessandra L Cecchini; Eliane C Arantes; Suzelei C França; José María Gutiérrez; José R Giglio
Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities.
The international journal of biochemistry & cell biology 2001;33(9):877-88.
2001: Marucia Chacur; Gisele Picolo; José María Gutiérrez; Catarina F P Teixeira; Yara Cury
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 2001;39(8):1173-81.
2001: Cecilia Díaz; Guillermo León; Alexandra Rucavado; N Rojas; A J Schroit; José María Gutiérrez
Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A(2): role of negatively charged phospholipids as potential membrane binding sites.
Archives of biochemistry and biophysics 2001;391(1):56-64.
2001: Veridiana M Rodrigues; Andreimar M Soares; Sílvia H Andrião-Escarso; AM Franceschi; A Rucavado; José María Gutiérrez; José R Giglio
Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom.
Biochimie 2001;83(6):471-9.
2001: Ermila Rojas; Patricia Saravia; Yamileth Angulo; Viviana Arce; Bruno Lomonte; J J Chávez; Rubén Velásquez; Monica Thelestam; José María Gutiérrez
Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2001;129(2):151-62.
2001: Guillermo León; M Monge; Ermila Rojas; Bruno Lomonte; José María Gutiérrez
Comparison between IgG and F(ab')(2) polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions.
Toxicon : official journal of the International Society on Toxinology 2001;39(6):793-801.
2001: Alexandra Rucavado; M Soto; Aura S Kamiguti; R David G Theakston; Jay W Fox; Teresa Escalante; José María Gutiérrez
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.
Thrombosis and haemostasis 2001;85(4):710-5.
2001: Andreimar M Soares; Sílvia H Andrião-Escarso; Raquel K Bortoleto; L Rodrigues-Simioni; Raghuvir K Arni; Richard J Ward; José María Gutiérrez; José R Giglio
Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom.
Archives of biochemistry and biophysics 2001;387(2):188-96.
2001: Mônica Lopes-Ferreira; Javier Núñez; Alexandra Rucavado; Sandra H P Farsky; Bruno Lomonte; Yamileth Angulo; Ana Maria Moura da Silva; José María Gutiérrez
Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice.
International journal of experimental pathology 2001;82(1):55-64.
2001: Patricia Saravia; Ermila Rojas; Teresa Escalante; Viviana Arce; Esteban Chaves; Rubén Velásquez; Bruno Lomonte; Gustavo Rojas; José María Gutiérrez
The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms.
Toxicon : official journal of the International Society on Toxinology 2001;39(2-3):401-5.
2000: Alexandra Rucavado; Teresa Escalante; AM Franceschi; Fernando Chaves; Guillermo León; Y Cury; M Ovadia; José María Gutiérrez
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.
The American journal of tropical medicine and hygiene 2000;63(5-6):313-9.
2000: G Bogarín; JF Morais; I K Yamaguchi; MA Stephano; J R Marcelino; A K Nishikawa; R Guidolin; Gustavo Rojas; Hisako Gondo Higashi; José María Gutiérrez
Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica.
Toxicon : official journal of the International Society on Toxinology 2000;38(10):1429-41.
2000: Márcia H Borges; Andreimar M Soares; Veridiana M Rodrigues; Sílvia H Andrião-Escarso; H Diniz; Amélia Hamaguchi; Aristides Quintero; S Lizano; José María Gutiérrez; José R Giglio; Maria Inês Homsi-Brandeburgo
Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;127(1):21-30.
2000: José María Gutiérrez; Alexandra Rucavado
Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage.
Biochimie 2000;82(9-10):841-50.
2000: Sílvia H Andrião-Escarso; Andreimar M Soares; Veridiana M Rodrigues; Yamileth Angulo; C Díaz; Bruno Lomonte; José María Gutiérrez; José R Giglio
Myotoxic phospholipases A(2) in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.
Biochimie 2000;82(8):755-63.
2000: Alberto Alape-Girón; Marietta Flores-Díaz; Isabelle Guillouard; Claire E Naylor; Richard Titball; Alexandra Rucavado; Bruno Lomonte; Ajit K Basak; José María Gutiérrez; Stewart T Cole; Monica Thelestam
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.
European journal of biochemistry / FEBS 2000;267(16):5191-7.
2000: Teresa Escalante; AM Franceschi; Alexandra Rucavado; José María Gutiérrez
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake bothrops asper.
Biochemical pharmacology 2000;60(2):269-74.
2000: Andreimar M Soares; Renata Guerra-Sá; Caroline R Borja-Oliveira; Veridiana M Rodrigues; Léa Rodrigues-Simioni; Vanderlei Rodrigues; Marcos R M Fontes; Bruno Lomonte; José María Gutiérrez; José R Giglio
Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom.
Archives of biochemistry and biophysics 2000;378(2):201-9.
2000: Sergio Lizano; Yamileth Angulo; Bruno Lomonte; Jay W Fox; G Lambeau; M Lazdunski; José María Gutiérrez
Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.
The Biochemical journal 2000;346 Pt 3():631-9.
2000: Guillermo León; J M Valverde; Gustavo Rojas; Bruno Lomonte; José María Gutiérrez
Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 2000;38(2):233-44.
2000: Sandra H P Farsky; L R C Gonçalves; José María Gutiérrez; A P Correa; Alexandra Rucavado; Philippe Gasque; D V Tambourgi
Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.
Mediators of inflammation 2000;9(5):213-21.
2000: AM Franceschi; Alexandra Rucavado; N Mora; José María Gutiérrez
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.
Toxicon : official journal of the International Society on Toxinology 2000;38(1):63-77.
2000: Andreimar M Soares; Sílvia H Andrião-Escarso; Yamileth Angulo; Bruno Lomonte; José María Gutiérrez; S Marangoni; M H Toyama; Raghuvir K Arni; José R Giglio
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom.
Archives of biochemistry and biophysics 2000;373(1):7-15.
1999: Alexandra Rucavado; E Flores-Sánchez; AM Franceschi; A Magalhaes; José María Gutiérrez
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom.
Toxicon : official journal of the International Society on Toxinology 1999;37(9):1297-312.
1999: Guillermo León; B Stiles; Alberto Alape; Gustavo Rojas; José María Gutiérrez
Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.
The American journal of tropical medicine and hygiene 1999;61(2):266-71.
1999: Rafael Otero; José María Gutiérrez; Gustavo Rojas; Vitelbina Núñez; Abel Díaz; E Miranda; A F Uribe; J F Silva; Jorge Ospina; Y Medina; María Fabiola Toro; ME García; Guillermo León; M García; S Lizano; J De La Torre; J Márquez; Y Mena; N González; L C Arenas; A Puzón; N Blanco; A Sierra; M E Espinal; R Lozano
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms.
Toxicon : official journal of the International Society on Toxinology 1999;37(6):895-908.
1999: G Bogarín; M Romero; Gustavo Rojas; C Lutsch; M Casadamont; J Lang; R Otero; José María Gutiérrez
Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothírops snake venoms.
Toxicon : official journal of the International Society on Toxinology 1999;37(3):551-7.
1999: Bruno Lomonte; Yamileth Angulo; S Rufini; Wonhwa Cho; J R Giglio; M Ohno; J J Daniele; P Geoghegan; José María Gutiérrez
Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro.
Toxicon : official journal of the International Society on Toxinology 1999;37(1):145-58.
1999: Alberto Alape-Girón; Bengt Persson; Ella Cederlund; Marietta Flores-Díaz; José María Gutiérrez; Monica Thelestam; Tomas Bergman; Hans Jörnvall
Elapid venom toxins: multiple recruitments of ancient scaffolds.
European journal of biochemistry / FEBS 1999;259(1-2):225-34.
1998: Rafael Otero; M F Furtado; C Gonçalves; Vitelbina Núñez; ME García; RG Osorio; M Romero; José María Gutiérrez
Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1998;36(12):2021-7.
1998: Fernando Chaves; Guillermo León; V H Alvarado; José María Gutiérrez
Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).
Toxicon : official journal of the International Society on Toxinology 1998;36(12):1861-9.
1998: José María Gutiérrez; Guillermo León; Gustavo Rojas; Bruno Lomonte; Alexandra Rucavado; Fernando Chaves
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1529-38.
1998: Alexandra Rucavado; Javier Núñez; José María Gutiérrez
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.
International journal of experimental pathology 1998;79(4):245-54.
1998: Guillermo León; R Estrada; Fernando Chaves; Gustavo Rojas; M Ovadia; José María Gutiérrez
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: application in horse immunization for antivenom production.
Toxicon : official journal of the International Society on Toxinology 1998;36(2):321-31.
1997: Gustavo Rojas; G Bogarín; José María Gutiérrez
Snakebite mortality in Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1997;35(11):1639-43.
1997: Guillermo León; Gustavo Rojas; Bruno Lomonte; José María Gutiérrez
Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 1997;35(11):1627-37.
1997: E Amuy; Alberto Alape-Girón; Bruno Lomonte; Monica Thelestam; José María Gutiérrez
Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species).
Toxicon : official journal of the International Society on Toxinology 1997;35(11):1605-16.
1997: Sergio Lizano; Bruno Lomonte; Jay W Fox; José María Gutiérrez
Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper.
The Biochemical journal 1997;326 ( Pt 3)():853-9.
1997: Alberto Alape-Girón; K Miranda-Arrieta; X Cortes-Bratti; B G Stiles; José María Gutiérrez
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus.
Toxicon : official journal of the International Society on Toxinology 1997;35(4):573-81.
1997: Yamileth Angulo; Esteban Chaves; Alberto Alape; Alexandra Rucavado; José María Gutiérrez; Bruno Lomonte
Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica.
Archives of biochemistry and biophysics 1997;339(2):260-6.
1997: Rafael Otero; Vitelbina Núñez; José María Gutiérrez; A Robles; R Estrada; RG Osorio; G Del-Valle; R Valderrama; C A Giraldo
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1997;30(3):375-9.
1997: C Díaz-Oreiro; José María Gutiérrez
Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties.
Toxicon : official journal of the International Society on Toxinology 1997;35(2):241-52.
1997: Yamileth Angulo; R Estrada; José María Gutiérrez
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom.
Toxicon : official journal of the International Society on Toxinology 1997;35(1):81-90.
1996: Rafael Otero; José María Gutiérrez; Vitelbina Núñez; A Robles; R Estrada; E Segura; María Fabiola Toro; ME García; A Díaz; E C Ramírez; G Gómez; J Castañeda; M E Moreno
A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. The Regional Group on Antivenom Therapy Research (REGATHER).
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(6):696-700.
1996: Alexandra Rucavado; Edgardo Moreno; José María Gutiérrez
Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(10):1337-40.
1995: Alexandra Rucavado; Bruno Lomonte; M Ovadia; José María Gutiérrez
Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom.
Experimental and molecular pathology 1995;63(3):186-99.
1995: José María Gutiérrez; Bruno Lomonte
Phospholipase A2 myotoxins from Bothrops snake venoms.
Toxicon : official journal of the International Society on Toxinology 1995;33(11):1405-24.
1995: G Borkow; José María Gutiérrez; M Ovadia
In vitro activity of BaH1, the main hemorrhagic toxin of Bothrops asper snake venom on bovine endothelial cells.
Toxicon : official journal of the International Society on Toxinology 1995;33(10):1387-91.
1995: G Bogarín; E Segura; G Durán; Bruno Lomonte; Gustavo Rojas; José María Gutiérrez
(Evaluation of neutralizing ability of four commercially available antivenoms against the venom of Bothrops asper from Costa Rica)
Toxicon : official journal of the International Society on Toxinology 1995;33(9):1242-7.
1995: Alexandra Rucavado; G Borkow; M Ovadia; José María Gutiérrez
Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper.
Toxicon : official journal of the International Society on Toxinology 1995;33(8):1103-6.
1995: Rafael Otero; V Nuñez; RG Osorio; José María Gutiérrez; C A Giraldo; L E Posada
Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia).
Toxicon : official journal of the International Society on Toxinology 1995;33(6):809-15.
1995: Jens Z Pedersen; Bruno Lomonte; Renato Massoud; F Gubensek; José María Gutiérrez; S Rufini
Autocatalytic acylation of phospholipase-like myotoxins.
Biochemistry 1995;34(14):4670-5.
1995: José María Gutiérrez; M Romero; J Núñez; Fernando Chaves; G Borkow; M Ovadia
Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (Terciopelo).
Experimental and molecular pathology 1995;62(1):28-41.
1995: Fernando Chaves; M Barboza; José María Gutiérrez
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice.
Toxicon : official journal of the International Society on Toxinology 1995;33(1):31-9.
1995: José María Gutiérrez; M Romero; C Díaz; G Borkow; M Ovadia
Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo).
Toxicon : official journal of the International Society on Toxinology 1995;33(1):19-29.
1995: C Díaz; Bruno Lomonte; F Zamudio; José María Gutiérrez
Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom.
Natural toxins 1995;3(1):26-31.
1994: G Borkow; Bruno Lomonte; José María Gutiérrez; M Ovadia
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro.
Toxicon : official journal of the International Society on Toxinology 1994;32(12):1689-95.
1994: C Díaz; A Alape; Bruno Lomonte; T Olamendi; José María Gutiérrez
Cleavage of the NH2-terminal octapeptide of Bothrops asper myotoxic lysine-49 phospholipase A2 reduces its membrane-destabilizing effect.
Archives of biochemistry and biophysics 1994;312(2):336-9.
1994: L Moreira; G Borkow; M Ovadia; José María Gutiérrez
Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels.
Toxicon : official journal of the International Society on Toxinology 1994;32(8):976-87.
1994: Alberto Alape-Girón; B Gustafsson; Bruno Lomonte; Monica Thelestam; José María Gutiérrez
Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies.
Toxicon : official journal of the International Society on Toxinology 1994;32(6):695-712.
1994: Bruno Lomonte; José María Gutiérrez; G Borkow; M Ovadia; A Tarkowski; L A Hanson
Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro.
Toxicon : official journal of the International Society on Toxinology 1994;32(4):505-10.
1994: Gustavo Rojas; J M Jiménez; José María Gutiérrez
Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production.
Toxicon : official journal of the International Society on Toxinology 1994;32(3):351-63.
1993: C Díaz; José María Gutiérrez; Bruno Lomonte; J Núñez
p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities.
Toxicon : official journal of the International Society on Toxinology 1993;31(9):1202-6.
1993: G Borkow; José María Gutiérrez; M Ovadia
Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper.
Toxicon : official journal of the International Society on Toxinology 1993;31(9):1137-50.
1993: L Calderón; Bruno Lomonte; José María Gutiérrez; A Tarkowski; L A Hanson
Biological and biochemical activities of Vipera berus (European viper) venom.
Toxicon : official journal of the International Society on Toxinology 1993;31(6):743-53.
1993: Bruno Lomonte; José María Gutiérrez; M Romero; J Núñez; A Tarkowski; L A Hanson
An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies.
Journal of immunological methods 1993;161(2):231-7.
1993: Gustavo Rojas; M Vargas; A Robles; José María Gutiérrez
Turbidity of hyperimmune equine antivenom: the role of phenol and serum lipoproteins.
Toxicon : official journal of the International Society on Toxinology 1993;31(1):61-6.
1992: S Rufini; P Cesaroni; Alessandro Desideri; R Farias; F Gubensek; José María Gutiérrez; Paolo Luly; Renato Massoud; Roberto D Morero; Jens Z Pedersen
Calcium ion independent membrane leakage induced by phospholipase-like myotoxins.
Biochemistry 1992;31(49):12424-30.
1992: C Díaz; José María Gutiérrez; Bruno Lomonte
Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom.
Archives of biochemistry and biophysics 1992;298(1):135-42.
1992: José María Gutiérrez; Gustavo Rojas; N J da Silva Júnior; J Núñez
Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes).
Toxicon : official journal of the International Society on Toxinology 1992;30(10):1299-302.
1992: L Moreira; José María Gutiérrez; G Borkow; M Ovadia
Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo).
Experimental and molecular pathology 1992;57(2):124-33.
1992: Fernando Chaves; José María Gutiérrez; Fernando Brenes
Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo).
Toxicon : official journal of the International Society on Toxinology 1992;30(9):1099-109.
1992: C Valiente; Edgardo Moreno; A Sittenfeld; Bruno Lomonte; José María Gutiérrez
An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes.
Toxicon : official journal of the International Society on Toxinology 1992;30(8):815-23.
1992: R Estrada; Fernando Chaves; A Robles; E Rojas; E Segura; José María Gutiérrez
[Hematologic values and serum enzymes in horses inoculated with snake venoms for the production of antivenins in Costa Rica].
Revista de biología tropical 1992;40(1):95-9.
1992: Bruno Lomonte; José María Gutiérrez; M Ramírez; C Díaz
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies.
Toxicon : official journal of the International Society on Toxinology 1992;30(3):239-45.
1992: M C dos-Santos; L R Gonçalves; C L Fortes-Dias; Yara Cury; José María Gutiérrez; M de F Furtado
[The efficacy of the bothropic-crotalic antivenom in the neutralization of the main Bothrops jararacussu venom effects].
Revista do Instituto de Medicina Tropical de São Paulo 1992;34(2):77-83.
1992: S Quirós; J A Gené; José María Gutiérrez; M Thelestam
Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1992;101(2):433-6.
1991: C Díaz; José María Gutiérrez; Bruno Lomonte; J A Gené
The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities.
Biochimica et biophysica acta 1991;1070(2):455-60.
1991: José María Gutiérrez; J Núñez; C Díaz; A C Cintra; Maria Inês Homsi-Brandeburgo; José R Giglio
Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu.
Experimental and molecular pathology 1991;55(3):217-29.
1991: V Arce; Fernando Brenes; José María Gutiérrez
Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study.
International journal of experimental pathology 1991;72(2):211-26.
1991: Bruno Lomonte; José María Gutiérrez; Gustavo Rojas; L Calderón
Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms.
Toxicon : official journal of the International Society on Toxinology 1991;29(6):695-702.
1991: José María Gutiérrez; Gustavo Rojas; A Pérez; I Argüello; Bruno Lomonte
Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1991;24(7):701-10.
1991: José María Gutiérrez; M C dos Santos; M de F Furtado; Gustavo Rojas
Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes.
Toxicon : official journal of the International Society on Toxinology 1991;29(10):1273-7.
1991: A Sittenfeld; H Raventós; R Cruz; José María Gutiérrez
DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants.
Toxicon : official journal of the International Society on Toxinology 1991;29(10):1213-24.
1990: José María Gutiérrez; V Arce; Fernando Brenes; Fernando Chaves
Changes in myofibrillar components after skeletal muscle necrosis induced by a myotoxin isolated from the venom of the snake Bothrops asper.
Experimental and molecular pathology 1990;52(1):25-36.
1990: José María Gutiérrez; C Avila; Z Camacho; Bruno Lomonte
Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1990;28(4):419-26.
1990: Bruno Lomonte; José María Gutiérrez; E Carmona; M E Rovira
Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability.
Toxicon : official journal of the International Society on Toxinology 1990;28(4):379-84.
1990: Gustavo Rojas; M Espinoza; Bruno Lomonte; José María Gutiérrez
Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1990;28(1):101-5.
1990: José María Gutiérrez; Gustavo Rojas; Bruno Lomonte; J A Gené; Fernando Chaves; J Alvarado; E Rojas
Standardization of assays for testing the neutralizing ability of antivenoms.
Toxicon : official journal of the International Society on Toxinology 1990;28(10):1127-9; author reply 1129-32.
1990: Bruno Lomonte; José María Gutiérrez; M F Furtado; Rafael Otero; J P Rosso; O Vargas; E Carmona; M E Rovira
Isolation of basic myotoxins from Bothrops moojeni and Bothrops atrox snake venoms.
Toxicon : official journal of the International Society on Toxinology 1990;28(10):1137-46.
1990: Bruno Lomonte; Gustavo Rojas; José María Gutiérrez; G Ramírez
Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper).
Toxicon : official journal of the International Society on Toxinology 1990;28(1):75-81.
1990: Bruno Lomonte; M F Furtado; M E Rovira; E Carmona; Gustavo Rojas; R Aymerich; José María Gutiérrez
South American snake venom proteins antigenically related to Bothrops asper myotoxins.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1990;23(5):427-35.
1989: R Estrada; José María Gutiérrez; J Alvarado; A Robles; C Avila; N González
[The development of the anti-phospholipase A2 antibody response in horses inoculated with venom for the production of polyvalent antisnake serum in Costa Rica].
Revista de biología tropical 1989;37(2):187-91.
1989: Fernando Chaves; José María Gutiérrez; Bruno Lomonte; L Cerdas
Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice.
Toxicon : official journal of the International Society on Toxinology 1989;27(10):1085-93.
1989: J A Gené; A Roy; Gustavo Rojas; José María Gutiérrez; L Cerdas
Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom.
Toxicon : official journal of the International Society on Toxinology 1989;27(8):841-8.
1989: José María Gutiérrez; Fernando Chaves; J A Gené; Bruno Lomonte; Z Camacho; K Schosinsky
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1989;27(7):735-45.
1989: Bruno Lomonte; José María Gutiérrez
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).
Toxicon : official journal of the International Society on Toxinology 1989;27(7):725-33.
1988: J Alvarado; José María Gutiérrez
Anticoagulant effect of myotoxic phospholipase A2 isolated from the venom of the snake Bothrops asper (Viperidae).
Revista de biología tropical 1988;36(2B):563-5.
1988: A Solórzano; José María Gutiérrez; L Cerdas
[Bothrops ophryomegas Bocourt (Serpentes: Viperidae) in Costa Rica: distribution, lepidosis, sexual variation and karyotype].
Revista de biología tropical 1988;36(2A):187-90.
1988: José María Gutiérrez; Fernando Chaves; E Rojas; J Elizondo; C Avila; L Cerdas
Production of monovalent anti-Bothrops asper antivenom: development of immune response in horses and neutralizing ability.
Revista de biología tropical 1988;36(2B):511-7.
1988: José María Gutiérrez; C Avila; E Rojas; L Cerdas
An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):411-3.
1988: Edgardo Moreno; José María Gutiérrez
Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):403-9.
1988: Edgardo Moreno; A Alape; M Sánchez; José María Gutiérrez
A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):363-71.
1987: Gustavo Rojas; José María Gutiérrez; J A Gené; M Gómez; L Cerdas
[Neutralization of toxic and enzyme activities of 4 venoms from snakes of Guatemala and Honduras by the polyvalent antivenin produced in Costa Rica].
Revista de biología tropical 1987;35(1):59-67.
1987: José María Gutiérrez; Gustavo Rojas; L Cerdas
Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster.
Toxicon : official journal of the International Society on Toxinology 1987;25(7):713-20.
1987: O Arroyo; J P Rosso; O Vargas; José María Gutiérrez; L Cerdas
Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus.
Comparative biochemistry and physiology. B, Comparative biochemistry 1987;87(4):949-52.
1987: José María Gutiérrez; Gustavo Rojas; Bruno Lomonte; J A Gené; L Cerdas
Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum.
Toxicon : official journal of the International Society on Toxinology 1987;25(11):1244-8.
1987: Bruno Lomonte; Edgardo Moreno; José María Gutiérrez
Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.
Toxicon : official journal of the International Society on Toxinology 1987;25(9):947-55.
1986: José María Gutiérrez; Fernando Chaves; L Cerdas
Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom.
Revista de biología tropical 1986;34(2):209-14.
1986: José María Gutiérrez; O Arroyo; Fernando Chaves; Bruno Lomonte; L Cerdas
Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice.
British journal of experimental pathology 1986;67(1):1-12.
1986: José María Gutiérrez; Fernando Chaves; E Mata; L Cerdas
Skeletal muscle regeneration after myonecrosis induced by Bothrops asper (terciopelo) venom.
Toxicon : official journal of the International Society on Toxinology 1986;24(3):223-31.
1986: José María Gutiérrez; Gustavo Rojas; Bruno Lomonte; J A Gené; L Cerdas
Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1986;85(1):171-5.
1986: José María Gutiérrez; Bruno Lomonte; Fernando Chaves; E Moreno; L Cerdas
Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1986;84(1):159-64.
1985: J A Gené; Bruno Lomonte; José María Gutiérrez; L Cerdas
[Changes in the electrophoretic pattern of the venom of the bushmaster (Lachesis muta stenophrys) stored under various conditions].
Revista de biología tropical 1985;33(1):63-5.
1985: J A Gené; M Gómez; José María Gutiérrez; L Cerdas
Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom.
Toxicon : official journal of the International Society on Toxinology 1985;23(6):1015-8.
1985: José María Gutiérrez; J A Gené; Gustavo Rojas; L Cerdas
Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom.
Toxicon : official journal of the International Society on Toxinology 1985;23(6):887-93.
1984: José María Gutiérrez; A Solórzano; L Cerdas
[Karyotype study of 5 species of Costa Rican snakes of the colubrid family].
Revista de biología tropical 1984;32(2):263-7.
1983: Bruno Lomonte; J A Gené; José María Gutiérrez; L Cerdas
[Comparative study of venoms of newborn and adult rattlesnakes (Crotalus durissus durissus)].
Toxicon : official journal of the International Society on Toxinology 1983;21(3):379-84.
1982: Bruno Lomonte; L Cerdas; J A Gené; José María Gutiérrez
Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia.
Toxicon : official journal of the International Society on Toxinology 1982;20(3):571-9.
1981: José María Gutiérrez; Fernando Chaves; R Bolaños; L Cerdas; E Rojans; O Arroyo; E Portilla
[Neutralization of local effects of Bothrops asper venom by polyvalent antivenin].
Toxicon : official journal of the International Society on Toxinology 1981;19(4):493-500.
1980: José María Gutiérrez; Fernando Chaves; R Bolaños
[Comparative study of venoms of newborn and adult specimens of Bothrops asper].
Revista de biología tropical 1980;28(2):341-51.
1980: José María Gutiérrez; O Arroyo; R Bolaños
[Myonecrosis, hemorrhage and edema induced by bothrops asper venom in white mice (author's transl)].
Toxicon : official journal of the International Society on Toxinology 1980;18(5-6):603-10.
1980: José María Gutiérrez; Fernando Chaves; E Rojas; R Bolaños
[Local effects induced by Micrurus nigrocinctus venom in white mice (author's transl)].
Toxicon : official journal of the International Society on Toxinology 1980;18(5-6):633-9.