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José María Gutiérrez
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76
Lomonte, Bruno
37
Rucavado, Alexandra
33
Rojas, Gustavo
27
Chaves, Fernando
22
León, Guillermo
20
Angulo, Yamileth
16
Escalante, Teresa
10
Ovadia, M
10
Teixeira, Catarina
10
Theakston, David
9
Otero, Rafael
8
Rojas, Ermila
8
Núñez, Vitelbina
8
Soares, Andreimar
8
Alape-Girón, Alberto
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All Publications
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2009: Gutiérrez José María
Bothrops asper: beauty and peril in the neotropics.
Toxicon : official journal of the International Society on Toxinology 2009;54(7):901-3.
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2009: Gutiérrez José María; Escalante Teresa; Rucavado Alexandra
Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.
Toxicon : official journal of the International Society on Toxinology 2009;54(7):976-87.
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2009: Gutiérrez José María; Rucavado Alexandra; Chaves Fernando; Díaz Cecilia; Escalante Teresa
Experimental pathology of local tissue damage induced by Bothrops asper snake venom.
Toxicon : official journal of the International Society on Toxinology 2009;54(7):958-75.
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2009: Escalante Teresa; Rucavado Alexandra; Pinto Antonio F M; Terra Renata M S; Gutiérrez José María; Fox Jay W
Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins.
Journal of proteome research 2009;8(11):5120-31.
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2009: Núñez Vitelbina; Cid Pedro; Sanz Libia; De La Torre Pilar; Angulo Yamileth; Lomonte Bruno; Gutiérrez José María; Calvete Juan J
Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.
Journal of proteomics 2009;73(1):57-78.
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2009: Herrera María; Meneses Fabricio; Gutiérrez José María; León Guillermo
Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production.
Biologicals : journal of the International Association of Biological Standardization 2009;37(4):230-4.
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2009: Calvete Juan J; Sanz Libia; Angulo Yamileth; Lomonte Bruno; Gutiérrez José María
Venoms, venomics, antivenomics.
FEBS letters 2009;583(11):1736-43.
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2009: Gutiérrez José María; Fan Hui Wen; Silvera Carmen L M; Angulo Yamileth
Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop.
Toxicon : official journal of the International Society on Toxinology 2009;53(6):625-30.
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2009: Segura Alvaro; Herrera María; González Esteban; Vargas Mariángela; Solano Gabriela; Gutiérrez José María; León Guillermo
Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature.
Toxicon : official journal of the International Society on Toxinology 2009;53(6):609-15.
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2009: Calvete Juan J; Borges Adolfo; Segura Alvaro; Flores-Díaz Marietta; Alape-Girón Alberto; Gutiérrez José María; Diez Nardy; De Sousa Leonardo; Kiriakos Demetrio; Sánchez Eladio; Faks José G; Escolano José; Sanz Libia
Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.
Journal of proteomics 2009;72(2):227-40.
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2009: Gutiérrez José María; Lomonte Bruno; León Guillermo; Alape-Girón Alberto; Flores-Díaz Marietta; Sanz Libia; Angulo Yamileth; Calvete Juan J
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.
Journal of proteomics 2009;72(2):165-82.
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2009: Moreira Vanessa; Gutiérrez José María; Amaral Rafaela Bacci; Zamunér Stella Regina; Teixeira Catarina de Fátima Pereira
Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro.
Prostaglandins, leukotrienes, and essential fatty acids 2009;80(2-3):107-14.
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2009: Lomonte Bruno; Angulo Yamileth; Sasa Mahmood; Gutiérrez José María
The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles.
Protein and peptide letters 2009;16(8):860-76.
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2008: Rucavado Alexandra; Henríquez Mónica; García Jonielle; Gutiérrez José María
Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom.
Toxicon : official journal of the International Society on Toxinology 2008;52(7):754-9.
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2008: León Guillermo; Segura Alvaro; Herrera María; Otero Rafael; França Francisco Oscar de Siqueira; Barbaro Katia Cristina; Cardoso João Luiz Costa; Wen Fan Hui; de Medeiros Carlos Roberto; Prado José Carlos Lopes; Malaque Ceila María Sant'Ana; Lomonte Bruno; Gutiérrez José María
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102(11):1115-9.
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2008: Gutiérrez José María; Sanz Libia; Escolano José; Fernández Julián; Lomonte Bruno; Angulo Yamileth; Rucavado Alexandra; Warrell David A; Calvete Juan J
Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom.
Journal of proteome research 2008;7(10):4396-408.
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2008: Jiménez Natalia; Escalante Teresa; Gutiérrez José María; Rucavado Alexandra
Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model.
The Journal of investigative dermatology 2008;128(10):2421-8.
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2008: Fernández Pablo; Gutiérrez José María
Mortality due to snakebite envenomation in Costa Rica (1993-2006).
Toxicon : official journal of the International Society on Toxinology 2008;52(3):530-3.
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2008: Moreira Vanessa; Gutiérrez José Maria; Soares Andreimar Martins; Zamunér Stella Regina; Purgatto Eduardo; Teixeira Catarina de Fátima Pereira
Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases.
Toxicon : official journal of the International Society on Toxinology 2008;52(3):428-39.
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2008: Montecucco C; Gutiérrez J M; Lomonte B
Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action.
Cellular and molecular life sciences : CMLS 2008;65(18):2897-912.
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2008: Lomonte Bruno; Escolano José; Fernández Julián; Sanz Libia; Angulo Yamileth; Gutiérrez José María; Calvete Juan J
Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii.
Journal of proteome research 2008;7(6):2445-57.
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2008: Angulo Yamileth; Escolano José; Lomonte Bruno; Gutiérrez José María; Sanz Libia; Calvete Juan J
Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi.
Journal of proteome research 2008;7(2):708-19.
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2008: Pérez A V; Rucavado A; Sanz L; Calvete J J; Gutiérrez J M
Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2008;41(1):12-7.
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2008: Gutiérrez José María; Ponce-Soto Luis Alberto; Marangoni Sergio; Lomonte Bruno
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue.
Toxicon : official journal of the International Society on Toxinology 2008;51(1):80-92.
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2008: Mora Javier; Mora Rodrigo; Lomonte Bruno; Gutiérrez José María
Effects of Bothrops asper Snake Venom on Lymphatic Vessels: Insights into a Hidden Aspect of Envenomation.
PLoS neglected tropical diseases 2008;2(10):e318.
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2007: Villalobos Juan Carlos; Mora Rodrigo; Lomonte Bruno; Gutiérrez José María; Angulo Yamileth
Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(8):1382-9.
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2007: León Guillermo; Rodríguez Miguel Angel; Rucavado Alexandra; Lomonte Bruno; Gutiérrez José María
Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations.
Biologicals : journal of the International Association of Biological Standardization 2007;35(1):5-11.
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2007: Gutiérrez José María; Higashi Hisako Gondo; Wen Fan Hui; Burnouf Thierry
Strengthening antivenom production in Central and South American public laboratories: report of a workshop.
Toxicon : official journal of the International Society on Toxinology 2007;49(1):30-5.
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2007: Gutiérrez José María; Lomonte Bruno; León Guillermo; Rucavado Alexandra; Chaves Fernando; Angulo Yamileth
Trends in snakebite envenomation therapy: scientific, technological and public health considerations.
Current pharmaceutical design 2007;13(28):2935-50.
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2006: Otero Rafael; León Guillermo; Gutiérrez José María; Rojas Gustavo; Toro María Fabiola; Barona Jacqueline; Rodríguez Verónica; Díaz Abel; Núñez Vitelbina; Quintana Juan Carlos; Ayala Shirley; Mosquera Diana; Conrado Lesdy L; Fernández Diego; Arroyo Yobana; Paniagua Carlos A; López Mercedes; Ospina Carlos E; Alzate Claudia; Fernández Jorge; Meza Jazmín J; Silva Juan F; Ramírez Patricia; Fabra Patricia E; Ramírez Eugenio; Córdoba Elkin; Arrieta Ana B; Warrell David A; Theakston R David G
Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(12):1173-82.
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2006: Escalante Teresa; Shannon John; Moura-da-Silva Ana M; Gutiérrez José María; Fox Jay W
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study.
Archives of biochemistry and biophysics 2006;455(2):144-53.
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2006: Quesada Lil; Sevcik Carlos; Lomonte Bruno; Rojas Ermila; Gutiérrez José María
Pharmacokinetics of whole IgG equine antivenom: comparison between normal and envenomed rabbits.
Toxicon : official journal of the International Society on Toxinology 2006;48(3):255-63.
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2006: Chaves F; Teixeira C F P; Gutiérrez J M
Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55(6):245-53.
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2006: Gutiérrez José María; Theakston R David G; Warrell David A
Confronting the neglected problem of snake bite envenoming: the need for a global partnership.
PLoS medicine 2006;3(6):e150.
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2006: Fernandes Cristina Maria; Zamuner Stella Regina; Zuliani Juliana Pavan; Rucavado Alexandra; Gutiérrez José Maria; Teixeira Catarina de Fátima Pereira
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines.
Toxicon : official journal of the International Society on Toxinology 2006;47(5):549-59.
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2006: Gutiérrez José María; Núñez Javier; Escalante Teresa; Rucavado Alexandra
Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase.
Microvascular research 2006;71(1):55-63.
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2006: Mora Rodrigo; Maldonado Alexis; Valverde Berta; Gutiérrez José María
Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line.
Toxicon : official journal of the International Society on Toxinology 2006;47(1):75-86.
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2005: Zamuner Stella Regina; Zuliani Juliana Pavan; Fernandes Cristina Maria; Gutiérrez José Maria; de Fátima Pereira Teixeira Catarina
Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration.
Toxicon : official journal of the International Society on Toxinology 2005;46(7):806-13.
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2005: Herrera María; León Guillermo; Segura Alvaro; Meneses Fabricio; Lomonte Bruno; Chippaux Jean Philippe; Gutiérrez José María
Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs.
Toxicon : official journal of the International Society on Toxinology 2005;46(7):775-81.
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2005: Zuliani Juliana Pavan; Gutiérrez José María; Casais e Silva Luciana Lyra; Coccuzzo Sampaio Sandra; Lomonte Bruno; Pereira Teixeira Catarina de Fátima
Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A(2).
Toxicon : official journal of the International Society on Toxinology 2005;46(5):523-32.
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2005: Gallagher Paul; Bao Yongde; Serrano Solange M T; Laing Gavin D; Theakston R David G; Gutiérrez José M; Escalante Teresa; Zigrino Paola; Moura-da-Silva Ana M; Nischt Roswitha; Mauch Cornelia; Moskaluk Christopher; Fox Jay W
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin.
Archives of biochemistry and biophysics 2005;441(1):1-15.
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2005: Angulo Yamileth; Gutiérrez José María; Soares Andreimar M; Cho Wonhwa; Lomonte Bruno
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation.
Toxicon : official journal of the International Society on Toxinology 2005;46(3):291-6.
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2005: Rucavado Alexandra; Soto Mónica; Escalante Teresa; Loría Gilbert D; Arni Raghuvir; Gutiérrez José María
Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.
Thrombosis and haemostasis 2005;94(1):123-31.
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2005: Gutiérrez José María; Rucavado Alexandra; Escalante Teresa; Díaz Cecilia
Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage.
Toxicon : official journal of the International Society on Toxinology 2005;45(8):997-1011.
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2005: Gutiérrez J M; Rojas E; Quesada L; León G; Núñez J; Laing G D; Sasa M; Renjifo J M; Nasidi A; Warrell D A; Theakston R D G; Rojas G
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(6):468-75.
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2005: Teixeira Catarina F P; Chaves Fernando; Zamunér Stella R; Fernandes Cristina M; Zuliani Juliana P; Cruz-Hofling María Alice; Fernandes Irene; Gutiérrez José María
Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom.
International journal of experimental pathology 2005;86(2):107-15.
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2005: Mora Rodrigo; Valverde Berta; Díaz Cecilia; Lomonte Bruno; Gutiérrez José María
A Lys49 phospholipase A(2) homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line.
Toxicon : official journal of the International Society on Toxinology 2005;45(5):651-60.
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2005: Zuliani Juliana P; Fernandes Cristina M; Zamuner Stella R; Gutiérrez José M; Teixeira Catarina F P
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity.
Toxicon : official journal of the International Society on Toxinology 2005;45(3):335-46.
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2005: Chaves Fernando; Teixeira Catarina F P; Gutiérrez José María
Role of TNF-alpha, IL-1beta and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice.
Toxicon : official journal of the International Society on Toxinology 2005;45(2):171-8.
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2005: Díaz Cecilia; Valverde Lorena; Brenes Oscar; Rucavado Alexandra; Gutiérrez José María
Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells.
Journal of cellular biochemistry 2005;94(3):520-8.
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2005: Rojas Ermila; Quesada Lil; Arce Viviana; Lomonte Bruno; Rojas Gustavo; Gutiérrez José María
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment.
Acta tropica 2005;93(1):85-95.
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2005: León Guillermo; Lomonte Bruno; Gutiérrez José María
Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols.
Toxicon : official journal of the International Society on Toxinology 2005;45(1):123-8.
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2004: Chacur Marucia; Gutiérrez José Maria; Milligan Erin D; Wieseler-Frank Julie; Britto Luiz R G; Maier Steven F; Watkins Linda R; Cury Yara
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
Pain 2004;111(1-2):65-76.
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2004: Urdaneta Aldo H; Bolaños Federico; Gutiérrez José María
Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2004;138(4):485-92.
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2004: Núñez Vitelbina; Arce Viviana; Gutiérrez José María; Lomonte Bruno
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox.
Toxicon : official journal of the International Society on Toxinology 2004;44(1):91-101.
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2004: Chacur Marucia; Milligan Erin D; Sloan Evan M; Wieseler-Frank Julie; Barrientos Ruth M; Martin David; Poole Stephen; Lomonte Brono; Gutiérrez Jose Maria; Maier Steven F; Cury Yara; Watkins Linda R
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Pain 2004;108(1-2):180-91.
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2004: Rucavado Alexandra; Escalante Teresa; Gutiérrez José María
Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation.
Toxicon : official journal of the International Society on Toxinology 2004;43(4):417-24.
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2004: Escalante Teresa; Rucavado Alexandra; Kamiguti Aura S; Theakston R David G; Gutiérrez José María
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.
Toxicon : official journal of the International Society on Toxinology 2004;43(2):213-7.
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2003: Gutiérrez José María; Ownby Charlotte L
Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity.
Toxicon : official journal of the International Society on Toxinology 2003;42(8):915-31.
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2003: Escalante Teresa; Núñez Javier; Moura da Silva Ana M; Rucavado Alexandra; Theakston R David G; Gutiérrez José María
Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom.
Toxicology and applied pharmacology 2003;193(1):17-28.
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2003: Teixeira C F P; Zamunér S R; Zuliani J P; Fernandes C M; Cruz-Hofling M A; Fernandes I; Chaves F; Gutiérrez J M
Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom.
Muscle & nerve 2003;28(4):449-59.
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2003: Watanabe Leandra; Shannon John D; Valente Richard H; Rucavado Alexandra; Alape-Girón Alberto; Kamiguti Aura S; Theakston R David G; Fox Jay W; Gutiérrez José María; Arni Raghuvir K
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.
Protein science : a publication of the Protein Society 2003;12(10):2273-81.
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2003: Loría Gilbert D; Rucavado Alexandra; Kamiguti Aura S; Theakston R David G; Fox Jay W; Alape Alberto; Gutiérrez José María
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.
Archives of biochemistry and biophysics 2003;418(1):13-24.
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2003: Saldarriaga Mónica María; Otero Rafael; Núñez Vitelbina; Toro Maria Fabiola; Díaz Abel; Gutiérrez José María
Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia.
Toxicon : official journal of the International Society on Toxinology 2003;42(4):405-11.
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2003: Arce Viviana; Rojas Ermila; Ownby Charlotte L; Rojas Gustavo; Gutiérrez José María
Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes.
Toxicon : official journal of the International Society on Toxinology 2003;41(7):851-60.
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2003: Chacur M; Longo I; Picolo G; Gutiérrez J M; Lomonte B; Guerra J L; Teixeira C F P; Cury Y
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.
Toxicon : official journal of the International Society on Toxinology 2003;41(6):667-78.
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2003: Chaves Fernando; Loría Gilbert D; Salazar Adriana; Gutiérrez José María
Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG.
Toxicon : official journal of the International Society on Toxinology 2003;41(2):237-44.
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2003: Gutiérrez José María; León Guillermo; Lomonte Bruno
Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.
Clinical pharmacokinetics 2003;42(8):721-41.
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2002: Picolo G; Chacur M; Gutiérrez J M; Teixeira C F P; Cury Y
Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2002;35(10):1221-8.
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2002: Gutiérrez José María
[Biomedical research in Revista de Biologia Tropical]
Revista de biología tropical 2002;50(3-4):941-9.
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2002: Lopes-Ferreira Mônica; Moura-da-Silva Ana Maria; Piran-Soares Ana Amélia; Angulo Yamileth; Lomonte Bruno; Gutiérrez José María; Farsky Sandra H P
Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment.
Toxicon : official journal of the International Society on Toxinology 2002;40(8):1141-147.
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2002: Gutiérrez José María
[Understanding snake venoms: 50 years of research in Latin America]
Revista de biología tropical 2002;50(2):377-94.
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2002: García Mildred; Monge María; León Guillermo; Lizano Sergio; Segura Eduardo; Solano Gabriela; Rojas Gustavo; Gutiérrez José María
Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation.
Biologicals : journal of the International Association of Biological Standardization 2002;30(2):143-51.
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2002: Watanabe L; Rucavado A; Kamiguti A; Theakston R D G; Gutiérrez J M; Arni R K
Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):1034-5.
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2002: Rucavado Alexandra; Escalante Teresa; Teixeira Catarina F P; Fernándes Cristina María; Diaz Cecilia; Gutiérrez José María
Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.
Mediators of inflammation 2002;11(2):121-8.
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2002: Saravia Patricia; Rojas Ermila; Arce Viviana; Guevara Corina; López Juan Carlos; Chaves Esteban; Velásquez Rubén; Rojas Gustavo; Gutiérrez José María
Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications.
Revista de biología tropical 2002;50(1):337-46.
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2001: Avila-Agüero M L; París M M; Hu S; Peterson P K; Gutiérrez J M; Lomonte B; Faingezicht I;
Systemic cytokine response in children bitten by snakes in Costa Rica.
Pediatric emergency care 2001;17(6):425-9.
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2001: Zamuner S R; Gutiérrez J M; Muscará M N; Teixeira S A; Teixeira C F
Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.
Toxicon : official journal of the International Society on Toxinology 2001;39(10):1505-13.
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2001: Soares A M; Mancin A C; Cecchini A L; Arantes E C; França S C; Gutiérrez J M; Giglio J R
Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities.
The international journal of biochemistry & cell biology 2001;33(9):877-88.
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2001: Chacur M; Picolo G; Gutiérrez J M; Teixeira C F; Cury Y
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 2001;39(8):1173-81.
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2001: Díaz C; León G; Rucavado A; Rojas N; Schroit A J; Gutiérrez J M
Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A(2): role of negatively charged phospholipids as potential membrane binding sites.
Archives of biochemistry and biophysics 2001;391(1):56-64.
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2001: Rodrigues V M; Soares A M; Andrião-Escarso S H; Franceschi A M; Rucavado A; Gutiérrez J M; Giglio J R
Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom.
Biochimie 2001;83(6):471-9.
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2001: Rojas E; Saravia P; Angulo Y; Arce V; Lomonte B; Chávez J J; Velásquez R; Thelestam M; Gutiérrez J M
Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2001;129(2):151-62.
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2001: León G; Monge M; Rojas E; Lomonte B; Gutiérrez J M
Comparison between IgG and F(ab')(2) polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions.
Toxicon : official journal of the International Society on Toxinology 2001;39(6):793-801.
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2001: Rucavado A; Soto M; Kamiguti A S; Theakston R D; Fox J W; Escalante T; Gutiérrez J M
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.
Thrombosis and haemostasis 2001;85(4):710-5.
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2001: Soares A M; Andrião-Escarso S H; Bortoleto R K; Rodrigues-Simioni L; Arni R K; Ward R J; Gutiérrez J M; Giglio J R
Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom.
Archives of biochemistry and biophysics 2001;387(2):188-96.
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2001: Lopes-Ferreira M; Núñez J; Rucavado A; Farsky S H; Lomonte B; Angulo Y; Moura Da Silva A M; Gutiérrez J M
Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice.
International journal of experimental pathology 2001;82(1):55-64.
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2001: Saravia P; Rojas E; Escalante T; Arce V; Chaves E; Velásquez R; Lomonte B; Rojas G; Gutiérrez J M
The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms.
Toxicon : official journal of the International Society on Toxinology 2001;39(2-3):401-5.
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2000: Rucavado A; Escalante T; Franceschi A; Chaves F; León G; Cury Y; Ovadia M; Gutiérrez J M
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.
The American journal of tropical medicine and hygiene 2000;63(5-6):313-9.
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2000: Bogarín G; Morais J F; Yamaguchi I K; Stephano M A; Marcelino J R; Nishikawa A K; Guidolin R; Rojas G; Higashi H G; Gutiérrez J M
Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica.
Toxicon : official journal of the International Society on Toxinology 2000;38(10):1429-41.
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2000: Borges M H; Soares A M; Rodrigues V M; Andrião-Escarso S H; Diniz H; Hamaguchi A; Quintero A; Lizano S; Gutiérrez J M; Giglio J R; Homsi-Brandeburgo M I
Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;127(1):21-30.
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2000: Gutiérrez J M; Rucavado A
Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage.
Biochimie 2000;82(9-10):841-50.
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2000: Andrião-Escarso S H; Soares A M; Rodrigues V M; Angulo Y; Díaz C; Lomonte B; Gutiérrez J M; Giglio J R
Myotoxic phospholipases A(2) in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.
Biochimie 2000;82(8):755-63.
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2000: Alape-Girón A; Flores-Díaz M; Guillouard I; Naylor C E; Titball R W; Rucavado A; Lomonte B; Basak A K; Gutiérrez J M; Cole S T; Thelestam M
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.
European journal of biochemistry / FEBS 2000;267(16):5191-7.
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2000: Escalante T; Franceschi A; Rucavado A; Gutiérrez J M
Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake bothrops asper.
Biochemical pharmacology 2000;60(2):269-74.
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2000: Soares A M; Guerra-Sá R; Borja-Oliveira C R; Rodrigues V M; Rodrigues-Simioni L; Rodrigues V; Fontes M R; Lomonte B; Gutiérrez J M; Giglio J R
Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom.
Archives of biochemistry and biophysics 2000;378(2):201-9.
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2000: Lizano S; Angulo Y; Lomonte B; Fox J W; Lambeau G; Lazdunski M; Gutiérrez J M
Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.
The Biochemical journal 2000;346 Pt 3():631-9.
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2000: León G; Valverde J M; Rojas G; Lomonte B; Gutiérrez J M
Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 2000;38(2):233-44.
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2000: Franceschi A; Rucavado A; Mora N; Gutiérrez J M
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.
Toxicon : official journal of the International Society on Toxinology 2000;38(1):63-77.
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2000: Soares A M; Andrião-Escarso S H; Angulo Y; Lomonte B; Gutiérrez J M; Marangoni S; Toyama M H; Arni R K; Giglio J R
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom.
Archives of biochemistry and biophysics 2000;373(1):7-15.
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2000: Farsky S H; Gonçalves L R; Gutiérrez J M; Correa A P; Rucavado A; Gasque P; Tambourgi D V
Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.
Mediators of inflammation 2000;9(5):213-21.
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1999: Rucavado A; Flores-Sánchez E; Franceschi A; Magalhaes A; Gutiérrez J M
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom.
Toxicon : official journal of the International Society on Toxinology 1999;37(9):1297-312.
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1999: León G; Stiles B; Alape A; Rojas G; Gutiérrez J M
Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.
The American journal of tropical medicine and hygiene 1999;61(2):266-71.
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1999: Otero R; Gutiérrez J M; Rojas G; Núñez V; Díaz A; Miranda E; Uribe A F; Silva J F; Ospina J G; Medina Y; Toro M F; García M E; León G; García M; Lizano S; De La Torre J; Márquez J; Mena Y; González N; Arenas L C; Puzón A; Blanco N; Sierra A; Espinal M E; Lozano R
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms.
Toxicon : official journal of the International Society on Toxinology 1999;37(6):895-908.
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1999: Bogarín G; Romero M; Rojas G; Lutsch C; Casadamont M; Lang J; Otero R; Gutiérrez J M
Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothírops snake venoms.
Toxicon : official journal of the International Society on Toxinology 1999;37(3):551-7.
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1999: Lomonte B; Angulo Y; Rufini S; Cho W; Giglio J R; Ohno M; Daniele J J; Geoghegan P; Gutiérrez J M
Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro.
Toxicon : official journal of the International Society on Toxinology 1999;37(1):145-58.
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1999: Alape-Girón A; Persson B; Cederlund E; Flores-Díaz M; Gutiérrez J M; Thelestam M; Bergman T; Jörnvall H
Elapid venom toxins: multiple recruitments of ancient scaffolds.
European journal of biochemistry / FEBS 1999;259(1-2):225-34.
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1998: Otero R; Furtado M F; Gonçalves C; Núñez V; García M E; Osorio R G; Romero M; Gutiérrez J M
Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1998;36(12):2021-7.
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1998: Chaves F; León G; Alvarado V H; Gutiérrez J M
Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).
Toxicon : official journal of the International Society on Toxinology 1998;36(12):1861-9.
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1998: Gutiérrez J M; León G; Rojas G; Lomonte B; Rucavado A; Chaves F
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1529-38.
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1998: Rucavado A; Núñez J; Gutiérrez J M
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.
International journal of experimental pathology 1998;79(4):245-54.
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1998: León G; Estrada R; Chaves F; Rojas G; Ovadia M; Gutiérrez J M
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: application in horse immunization for antivenom production.
Toxicon : official journal of the International Society on Toxinology 1998;36(2):321-31.
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1997: Rojas G; Bogarín G; Gutiérrez J M
Snakebite mortality in Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1997;35(11):1639-43.
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1997: León G; Rojas G; Lomonte B; Gutiérrez J M
Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.
Toxicon : official journal of the International Society on Toxinology 1997;35(11):1627-37.
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1997: Amuy E; Alape-Girón A; Lomonte B; Thelestam M; Gutiérrez J M
Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species).
Toxicon : official journal of the International Society on Toxinology 1997;35(11):1605-16.
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1997: Lizano S; Lomonte B; Fox J W; Gutiérrez J M
Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper.
The Biochemical journal 1997;326 ( Pt 3)():853-9.
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1997: Alape-Girón A; Miranda-Arrieta K; Cortes-Bratti X; Stiles B G; Gutiérrez J M
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus.
Toxicon : official journal of the International Society on Toxinology 1997;35(4):573-81.
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1997: Otero R; Núñez V; Gutiérrez J M; Robles A; Estrada R; Osorio R G; Del-Valle G; Valderrama R; Giraldo C A
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1997;30(3):375-9.
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1997: Angulo Y; Chaves E; Alape A; Rucavado A; Gutiérrez J M; Lomonte B
Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica.
Archives of biochemistry and biophysics 1997;339(2):260-6.
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1997: Díaz-Oreiro C; Gutiérrez J M
Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties.
Toxicon : official journal of the International Society on Toxinology 1997;35(2):241-52.
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1997: Angulo Y; Estrada R; Gutiérrez J M
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom.
Toxicon : official journal of the International Society on Toxinology 1997;35(1):81-90.
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1996: Otero R; Gutiérrez J M; Núñez V; Robles A; Estrada R; Segura E; Toro M F; García M E; Díaz A; Ramírez E C; Gómez G; Castañeda J; Moreno M E
A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia. The Regional Group on Antivenom Therapy Research (REGATHER).
Transactions of the Royal Society of Tropical Medicine and Hygiene 1996;90(6):696-700.
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1996: Rucavado A; Moreno E; Gutiérrez J M
Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(10):1337-40.
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1995: Rucavado A; Lomonte B; Ovadia M; Gutiérrez J M
Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom.
Experimental and molecular pathology 1995;63(3):186-99.
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1995: Gutiérrez J M; Lomonte B
Phospholipase A2 myotoxins from Bothrops snake venoms.
Toxicon : official journal of the International Society on Toxinology 1995;33(11):1405-24.
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1995: Borkow G; Gutiérrez J M; Ovadia M
In vitro activity of BaH1, the main hemorrhagic toxin of Bothrops asper snake venom on bovine endothelial cells.
Toxicon : official journal of the International Society on Toxinology 1995;33(10):1387-91.
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1995: Bogarín G; Segura E; Durán G; Lomonte B; Rojas G; Gutiérrez J M
(Evaluation of neutralizing ability of four commercially available antivenoms against the venom of Bothrops asper from Costa Rica)
Toxicon : official journal of the International Society on Toxinology 1995;33(9):1242-7.
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1995: Rucavado A; Borkow G; Ovadia M; Gutiérrez J M
Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper.
Toxicon : official journal of the International Society on Toxinology 1995;33(8):1103-6.
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1995: Otero R; Nuñez V; Osorio R G; Gutiérrez J M; Giraldo C A; Posada L E
Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia).
Toxicon : official journal of the International Society on Toxinology 1995;33(6):809-15.
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1995: Pedersen J Z; Lomonte B; Massoud R; Gubensek F; Gutiérrez J M; Rufini S
Autocatalytic acylation of phospholipase-like myotoxins.
Biochemistry 1995;34(14):4670-5.
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1995: Gutiérrez J M; Romero M; Núñez J; Chaves F; Borkow G; Ovadia M
Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (Terciopelo).
Experimental and molecular pathology 1995;62(1):28-41.
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1995: Chaves F; Barboza M; Gutiérrez J M
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice.
Toxicon : official journal of the International Society on Toxinology 1995;33(1):31-9.
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1995: Gutiérrez J M; Romero M; Díaz C; Borkow G; Ovadia M
Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo).
Toxicon : official journal of the International Society on Toxinology 1995;33(1):19-29.
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1995: Díaz C; Lomonte B; Zamudio F; Gutiérrez J M
Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom.
Natural toxins 1995;3(1):26-31.
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1994: Borkow G; Lomonte B; Gutiérrez J M; Ovadia M
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro.
Toxicon : official journal of the International Society on Toxinology 1994;32(12):1689-95.
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1994: Díaz C; Alape A; Lomonte B; Olamendi T; Gutiérrez J M
Cleavage of the NH2-terminal octapeptide of Bothrops asper myotoxic lysine-49 phospholipase A2 reduces its membrane-destabilizing effect.
Archives of biochemistry and biophysics 1994;312(2):336-9.
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1994: Moreira L; Borkow G; Ovadia M; Gutiérrez J M
Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels.
Toxicon : official journal of the International Society on Toxinology 1994;32(8):976-87.
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1994: Alape-Girón A; Gustafsson B; Lomonte B; Thelestam M; Gutiérrez J M
Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies.
Toxicon : official journal of the International Society on Toxinology 1994;32(6):695-712.
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1994: Lomonte B; Gutiérrez J M; Borkow G; Ovadia M; Tarkowski A; Hanson L A
Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro.
Toxicon : official journal of the International Society on Toxinology 1994;32(4):505-10.
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1994: Rojas G; Jiménez J M; Gutiérrez J M
Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production.
Toxicon : official journal of the International Society on Toxinology 1994;32(3):351-63.
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1993: Díaz C; Gutiérrez J M; Lomonte B; Núñez J
p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities.
Toxicon : official journal of the International Society on Toxinology 1993;31(9):1202-6.
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1993: Borkow G; Gutiérrez J M; Ovadia M
Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper.
Toxicon : official journal of the International Society on Toxinology 1993;31(9):1137-50.
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1993: Calderón L; Lomonte B; Gutiérrez J M; Tarkowski A; Hanson L A
Biological and biochemical activities of Vipera berus (European viper) venom.
Toxicon : official journal of the International Society on Toxinology 1993;31(6):743-53.
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1993: Lomonte B; Gutiérrez J M; Romero M; Núñez J; Tarkowski A; Hanson L A
An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies.
Journal of immunological methods 1993;161(2):231-7.
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1993: Rojas G; Vargas M; Robles A; Gutiérrez J M
Turbidity of hyperimmune equine antivenom: the role of phenol and serum lipoproteins.
Toxicon : official journal of the International Society on Toxinology 1993;31(1):61-6.
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1992: Rufini S; Cesaroni P; Desideri A; Farias R; Gubensek F; Gutiérrez J M; Luly P; Massoud R; Morero R; Pedersen J Z
Calcium ion independent membrane leakage induced by phospholipase-like myotoxins.
Biochemistry 1992;31(49):12424-30.
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1992: Díaz C; Gutiérrez J M; Lomonte B
Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom.
Archives of biochemistry and biophysics 1992;298(1):135-42.
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1992: Gutiérrez J M; Rojas G; da Silva Júnior N J; Núñez J
Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes).
Toxicon : official journal of the International Society on Toxinology 1992;30(10):1299-302.
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1992: Moreira L; Gutiérrez J M; Borkow G; Ovadia M
Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo).
Experimental and molecular pathology 1992;57(2):124-33.
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1992: Chaves F; Gutiérrez J M; Brenes F
Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo).
Toxicon : official journal of the International Society on Toxinology 1992;30(9):1099-109.
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1992: Valiente C; Moreno E; Sittenfeld A; Lomonte B; Gutiérrez J M
An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes.
Toxicon : official journal of the International Society on Toxinology 1992;30(8):815-23.
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1992: Estrada R; Chaves F; Robles A; Rojas E; Segura E; Gutiérrez J M
[Hematologic values and serum enzymes in horses inoculated with snake venoms for the production of antivenins in Costa Rica]
Revista de biología tropical 1992;40(1):95-9.
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1992: Lomonte B; Gutiérrez J M; Ramírez M; Díaz C
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies.
Toxicon : official journal of the International Society on Toxinology 1992;30(3):239-45.
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1992: dos-Santos M C; Gonçalves L R; Fortes-Dias C L; Cury Y; Gutiérrez J M; Furtado M de F
[The efficacy of the bothropic-crotalic antivenom in the neutralization of the main Bothrops jararacussu venom effects]
Revista do Instituto de Medicina Tropical de São Paulo 1992;34(2):77-83.
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1992: Quirós S; Gené J A; Gutiérrez J M; Thelestam M
Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1992;101(2):433-6.
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1991: Díaz C; Gutiérrez J M; Lomonte B; Gené J A
The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities.
Biochimica et biophysica acta 1991;1070(2):455-60.
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1991: Gutiérrez J M; Núñez J; Díaz C; Cintra A C; Homsi-Brandeburgo M I; Giglio J R
Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu.
Experimental and molecular pathology 1991;55(3):217-29.
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1991: Arce V; Brenes F; Gutiérrez J M
Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study.
International journal of experimental pathology 1991;72(2):211-26.
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1991: Lomonte B; Gutiérrez J M; Rojas G; Calderón L
Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms.
Toxicon : official journal of the International Society on Toxinology 1991;29(6):695-702.
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1991: Gutiérrez J M; Rojas G; Pérez A; Argüello I; Lomonte B
Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1991;24(7):701-10.
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1991: Gutiérrez J M; dos Santos M C; Furtado M de F; Rojas G
Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes.
Toxicon : official journal of the International Society on Toxinology 1991;29(10):1273-7.
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1991: Sittenfeld A; Raventós H; Cruz R; Gutiérrez J M
DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants.
Toxicon : official journal of the International Society on Toxinology 1991;29(10):1213-24.
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1990: Gutiérrez J M; Arce V; Brenes F; Chaves F
Changes in myofibrillar components after skeletal muscle necrosis induced by a myotoxin isolated from the venom of the snake Bothrops asper.
Experimental and molecular pathology 1990;52(1):25-36.
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1990: Gutiérrez J M; Avila C; Camacho Z; Lomonte B
Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1990;28(4):419-26.
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1990: Lomonte B; Gutiérrez J M; Carmona E; Rovira M E
Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability.
Toxicon : official journal of the International Society on Toxinology 1990;28(4):379-84.
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1990: Rojas G; Espinoza M; Lomonte B; Gutiérrez J M
Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1990;28(1):101-5.
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1990: Gutiérrez J M; Rojas G; Lomonte B; Gené J A; Chaves F; Alvarado J; Rojas E
Standardization of assays for testing the neutralizing ability of antivenoms.
Toxicon : official journal of the International Society on Toxinology 1990;28(10):1127-9; author reply 1129-32.
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1990: Lomonte B; Gutiérrez J M; Furtado M F; Otero R; Rosso J P; Vargas O; Carmona E; Rovira M E
Isolation of basic myotoxins from Bothrops moojeni and Bothrops atrox snake venoms.
Toxicon : official journal of the International Society on Toxinology 1990;28(10):1137-46.
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1990: Lomonte B; Rojas G; Gutiérrez J M; Ramírez G
Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper).
Toxicon : official journal of the International Society on Toxinology 1990;28(1):75-81.
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1990: Lomonte B; Furtado M F; Rovira M E; Carmona E; Rojas G; Aymerich R; Gutiérrez J M
South American snake venom proteins antigenically related to Bothrops asper myotoxins.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1990;23(5):427-35.
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1989: Estrada R; Gutiérrez J M; Alvarado J; Robles A; Avila C; González N
[The development of the anti-phospholipase A2 antibody response in horses inoculated with venom for the production of polyvalent antisnake serum in Costa Rica]
Revista de biología tropical 1989;37(2):187-91.
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1989: Chaves F; Gutiérrez J M; Lomonte B; Cerdas L
Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice.
Toxicon : official journal of the International Society on Toxinology 1989;27(10):1085-93.
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1989: Gené J A; Roy A; Rojas G; Gutiérrez J M; Cerdas L
Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom.
Toxicon : official journal of the International Society on Toxinology 1989;27(8):841-8.
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1989: Gutiérrez J M; Chaves F; Gené J A; Lomonte B; Camacho Z; Schosinsky K
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1989;27(7):735-45.
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1989: Lomonte B; Gutiérrez J M
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).
Toxicon : official journal of the International Society on Toxinology 1989;27(7):725-33.
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1988: Alvarado J; Gutiérrez J M
Anticoagulant effect of myotoxic phospholipase A2 isolated from the venom of the snake Bothrops asper (Viperidae).
Revista de biología tropical 1988;36(2B):563-5.
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1988: Solórzano A; Gutiérrez J M; Cerdas L
[Bothrops ophryomegas Bocourt (Serpentes: Viperidae) in Costa Rica: distribution, lepidosis, sexual variation and karyotype]
Revista de biología tropical 1988;36(2A):187-90.
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1988: Gutiérrez J M; Chaves F; Rojas E; Elizondo J; Avila C; Cerdas L
Production of monovalent anti-Bothrops asper antivenom: development of immune response in horses and neutralizing ability.
Revista de biología tropical 1988;36(2B):511-7.
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1988: Gutiérrez J M; Avila C; Rojas E; Cerdas L
An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):411-3.
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1988: Moreno E; Gutiérrez J M
Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):403-9.
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1988: Moreno E; Alape A; Sánchez M; Gutiérrez J M
A new method for the detection of phospholipase A2 variants: identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes.
Toxicon : official journal of the International Society on Toxinology 1988;26(4):363-71.
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1987: Rojas G; Gutiérrez J M; Gené J A; Gómez M; Cerdas L
[Neutralization of toxic and enzyme activities of 4 venoms from snakes of Guatemala and Honduras by the polyvalent antivenin produced in Costa Rica]
Revista de biología tropical 1987;35(1):59-67.
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1987: Gutiérrez J M; Rojas G; Cerdas L
Ability of a polyvalent antivenom to neutralize the venom of Lachesis muta melanocephala, a new Costa Rican subspecies of the bushmaster.
Toxicon : official journal of the International Society on Toxinology 1987;25(7):713-20.
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1987: Arroyo O; Rosso J P; Vargas O; Gutiérrez J M; Cerdas L
Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus.
Comparative biochemistry and physiology. B, Comparative biochemistry 1987;87(4):949-52.
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1987: Gutiérrez J M; Rojas G; Lomonte B; Gené J A; Cerdas L
Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum.
Toxicon : official journal of the International Society on Toxinology 1987;25(11):1244-8.
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1987: Lomonte B; Moreno E; Gutiérrez J M
Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.
Toxicon : official journal of the International Society on Toxinology 1987;25(9):947-55.
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1986: Gutiérrez J M; Chaves F; Cerdas L
Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom.
Revista de biología tropical 1986;34(2):209-14.
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1986: Gutiérrez J M; Arroyo O; Chaves F; Lomonte B; Cerdas L
Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice.
British journal of experimental pathology 1986;67(1):1-12.
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1986: Gutiérrez J M; Chaves F; Mata E; Cerdas L
Skeletal muscle regeneration after myonecrosis induced by Bothrops asper (terciopelo) venom.
Toxicon : official journal of the International Society on Toxinology 1986;24(3):223-31.
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1986: Gutiérrez J M; Rojas G; Lomonte B; Gené J A; Cerdas L
Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1986;85(1):171-5.
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1986: Gutiérrez J M; Lomonte B; Chaves F; Moreno E; Cerdas L
Pharmacological activities of a toxic phospholipase A isolated from the venom of the snake Bothrops asper.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1986;84(1):159-64.
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1985: Gené J A; Lomonte B; Gutiérrez J M; Cerdas L
[Changes in the electrophoretic pattern of the venom of the bushmaster (Lachesis muta stenophrys) stored under various conditions]
Revista de biología tropical 1985;33(1):63-5.
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1985: Gené J A; Gómez M; Gutiérrez J M; Cerdas L
Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom.
Toxicon : official journal of the International Society on Toxinology 1985;23(6):1015-8.
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1985: Gutiérrez J M; Gené J A; Rojas G; Cerdas L
Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom.
Toxicon : official journal of the International Society on Toxinology 1985;23(6):887-93.
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1984: Gutiérrez J M; Solórzano A; Cerdas L
[Karyotype study of 5 species of Costa Rican snakes of the colubrid family]
Revista de biología tropical 1984;32(2):263-7.
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1983: Lomonte B; Gené J A; Gutiérrez J M; Cerdas L
[Comparative study of venoms of newborn and adult rattlesnakes (Crotalus durissus durissus)]
Toxicon : official journal of the International Society on Toxinology 1983;21(3):379-84.
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1982: Lomonte B; Cerdas L; Gené J A; Gutiérrez J M
Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia.
Toxicon : official journal of the International Society on Toxinology 1982;20(3):571-9.
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1981: Gutiérrez J M; Chaves F; Bolaños R; Cerdas L; Rojans E; Arroyo O; Portilla E
[Neutralization of local effects of Bothrops asper venom by polyvalent antivenin]
Toxicon : official journal of the International Society on Toxinology 1981;19(4):493-500.
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1980: Gutiérrez J M; Chaves F; Bolaños R
[Comparative study of venoms of newborn and adult specimens of Bothrops asper]
Revista de biología tropical 1980;28(2):341-51.
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1980: Gutiérrez J M; Arroyo O; Bolaños R
[Myonecrosis, hemorrhage and edema induced by bothrops asper venom in white mice (author's transl)]
Toxicon : official journal of the International Society on Toxinology 1980;18(5-6):603-10.
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1980: Gutiérrez J M; Chaves F; Rojas E; Bolaños R
[Local effects induced by Micrurus nigrocinctus venom in white mice (author's transl)]
Toxicon : official journal of the International Society on Toxinology 1980;18(5-6):633-9.
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