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David Gutmann

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
19
Guha, Abhijit
17
Perry, Arie
16
Collins, Francis
11
Haipek, Carrie
10
Uhlmann, Erik
9
Lau, Nelson
9
Hegedűs, Balázs
8
Bajenaru, Michaela
8
Garbow, Joel
7
Hedrick, Nicolé
7
Dasgupta, Biplab
7
Pulst, Stefan-M
7
Perry, Arie
7
Newsham, Irene
6
Watson, Mark

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Publications

TOP 3
Yu J; Deshmukh H; Gutmann R J; Emnett R J; Rodriguez F J; Watson M A; Nagarajan R; Gutmann D H
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Dickinson P J; Surace E I; Cambell M; Higgins R J; Leutenegger C M; Bollen A W; LeCouteur R A; Gutmann D H
Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas.
Nunley Kara S; Gao Feng; Albers Anne C; Bayliss Susan J; Gutmann David H
Predictive value of café au lait macules at initial consultation in the diagnosis of neurofibromatosis type 1.

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All Publications

2009: Yu J; Deshmukh H; Gutmann R J; Emnett R J; Rodriguez F J; Watson M A; Nagarajan R; Gutmann D H
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Neurology 2009;73(19):1526-31.
2009: Dickinson P J; Surace E I; Cambell M; Higgins R J; Leutenegger C M; Bollen A W; LeCouteur R A; Gutmann D H
Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas.
Veterinary pathology 2009;46(5):884-92.
2009: Nunley Kara S; Gao Feng; Albers Anne C; Bayliss Susan J; Gutmann David H
Predictive value of café au lait macules at initial consultation in the diagnosis of neurofibromatosis type 1.
Archives of dermatology 2009;145(8):883-7.
2009: Yeh Tu-Hsueh; Lee Da Yong; Gianino Scott M; Gutmann David H
Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation.
Glia 2009;57(11):1239-49.
2009: Tibbetts Kathleen M; Emnett Ryan J; Gao Feng; Perry Arie; Gutmann David H; Leonard Jeffrey Russell
Histopathologic predictors of pilocytic astrocytoma event-free survival.
Acta neuropathologica 2009;117(6):657-65.
2009: Hegedus Balazs; Hughes Frank W; Garbow Joel R; Gianino Scott; Banerjee Debasish; Kim Keunyoung; Ellisman Mark H; Brantley Milam A; Gutmann David H
Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma.
Journal of neuropathology and experimental neurology 2009;68(5):542-51.
2009: Albers Anne C; Gutmann David H
Gliomas in patients with neurofibromatosis type 1.
Expert review of neurotherapeutics 2009;9(4):535-9.
2009: Houshmandi S Sean; Emnett Ryan J; Giovannini Marco; Gutmann David H
The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner.
Molecular and cellular biology 2009;29(6):1472-86.
2009: Williams Virginia C; Lucas John; Babcock Michael A; Gutmann David H; Korf Bruce; Maria Bernard L
Neurofibromatosis type 1 revisited.
Pediatrics 2009;123(1):124-33.
2009: Gutmann David H
Modeling human brain tumors in mice.
Brain pathology (Zurich, Switzerland) 2009;19(1):108-11.
2009: Filion C; Motoi T; Olshen A B; Laé M; Emnett R J; Gutmann D H; Perry A; Ladanyi M; Labelle Y
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
The Journal of pathology 2009;217(1):83-93.
2008: Daginakatte Girish C; Gianino Scott M; Zhao Nina W; Parsadanian Alexander S; Gutmann David H
Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation.
Cancer research 2008;68(24):10358-66.
2008: Rodriguez Fausto J; Giannini Caterina; Asmann Yan W; Sharma Mukesh K; Perry Arie; Tibbetts Kathleen M; Jenkins Robert B; Scheithauer Bernd W; Anant Shrikant; Jenkins Sarah; Eberhart Charles G; Sarkaria Jann N; Gutmann David H
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.
Journal of neuropathology and experimental neurology 2008;67(12):1194-204.
2008: Jost Sarah C; Ackerman Joseph W; Garbow Joel R; Manwaring Linda P; Gutmann David H; McKinstry Robert C
Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma.
Pediatric radiology 2008;38(12):1293-9.
2008: Striedinger Katherine; VandenBerg Scott R; Baia Gilson S; McDermott Michael W; Gutmann David H; Lal Anita
The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.
Neoplasia (New York, N.Y.) 2008;10(11):1204-12.
2008: Tepel Martin; Roerig Peter; Wolter Marietta; Gutmann David H; Perry Arie; Reifenberger Guido; Riemenschneider Markus J
Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma.
International journal of cancer. Journal international du cancer 2008;123(9):2080-6.
2008: Cui Yijun; Costa Rui M; Murphy Geoffrey G; Elgersma Ype; Zhu Yuan; Gutmann David H; Parada Luis F; Mody Istvan; Silva Alcino J
Neurofibromin regulation of ERK signaling modulates GABA release and learning.
Cell 2008;135(3):549-60.
2008: Gutmann David H
Using neurofibromatosis-1 to better understand and treat pediatric low-grade glioma.
Journal of child neurology 2008;23(10):1186-94.
2008: Hegedus Balazs; Yeh Tu-Hsueh; Lee Da Yong; Emnett Ryan J; Li Jia; Gutmann David H
Neurofibromin regulates somatic growth through the hypothalamic-pituitary axis.
Human molecular genetics 2008;17(19):2956-66.
2008: Patil Sushama; Perry Arie; Maccollin Mia; Dong Shumin; Betensky Rebecca A; Yeh Tu-Hsueh; Gutmann David H; Stemmer-Rachamimov Anat O
Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas.
Brain pathology (Zurich, Switzerland) 2008;18(4):517-9.
2008: Drögemüller Katrin; Helmuth Ulrike; Brunn Anna; Sakowicz-Burkiewicz Monika; Gutmann David H; Mueller Werner; Deckert Martina; Schlüter Dirk
Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2683-93.
2008: Deshmukh H; Yeh T H; Yu J; Sharma M K; Perry A; Leonard J R; Watson M A; Gutmann D H; Nagarajan R
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.
Oncogene 2008;27(34):4745-51.
2008: Lau Ying-Ka Ingar; Murray Lucas B; Houshmandi Sean S; Xu Yin; Gutmann David H; Yu Qin
Merlin is a potent inhibitor of glioma growth.
Cancer research 2008;68(14):5733-42.
2008: Reilly Karlyne M; Rubin Joshua B; Gilbertson Richard J; Garbow Joel R; Roussel Martine F; Gutmann David H
Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop.
Cancer research 2008;68(14):5508-11.
2008: Elghazi Lynda; Weiss Aaron J; Gould Aaron P; Hegedus Balazs; Gutmann David H; Bernal-Mizrachi Ernesto
Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.
Genesis (New York, N.Y. : 2000) 2008;46(5):256-64.
2008: Yan Qun; Zhang Zhi-Fa; Chen Xiao-Ping; Gutmann David H; Xiong Min; Xiao Zhen-Yu; Huang Zhi-Yong
Reduced T-cadherin expression and promoter methylation are associated with the development and progression of hepatocellular carcinoma.
International journal of oncology 2008;32(5):1057-63.
2008: Zeng Ling-Hui; Xu Lin; Gutmann David H; Wong Michael
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.
Annals of neurology 2008;63(4):444-53.
2008: Rodriguez Fausto J; Perry Arie; Gutmann David H; O'Neill Brian Patrick; Leonard Jeffrey; Bryant Sandra; Giannini Caterina
Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients.
Journal of neuropathology and experimental neurology 2008;67(3):240-9.
2008: Hegedus Balazs; Banerjee Debasish; Yeh Tu-Hsueh; Rothermich Stefan; Perry Arie; Rubin Joshua B; Garbow Joel R; Gutmann David H
Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.
Cancer research 2008;68(5):1520-8.
2008: Yamanaka Koji; Chun Seung Joo; Boillee Severine; Fujimori-Tonou Noriko; Yamashita Hirofumi; Gutmann David H; Takahashi Ryosuke; Misawa Hidemi; Cleveland Don W
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.
Nature neuroscience 2008;11(3):251-3.
2008: Daginakatte Girish C; Gadzinski Adam; Emnett Ryan J; Stark Jennifer L; Gonzales Ernesto R; Yan Ping; Lee Jin-Moo; Cross Anne H; Gutmann David H
Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines.
Experimental neurology 2008;210(1):261-7.
2007: Leonard J R; Ferner R E; Thomas N; Gutmann D H
Cervical cord compression from plexiform neurofibromas in neurofibromatosis 1.
Journal of neurology, neurosurgery, and psychiatry 2007;78(12):1404-6.
2007: Lee Da Yong; Gutmann David H
Cancer stem cells and brain tumors: uprooting the bad seeds.
Expert review of anticancer therapy 2007;7(11):1581-90.
2007: Komine Okiru; Nagaoka Mai; Watase Kei; Gutmann David H; Tanigaki Kenji; Honjo Tasuku; Radtke Freddy; Saito Toshiki; Chiba Shigeru; Tanaka Kohichi
The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling.
Developmental biology 2007;311(1):238-50.
2007: Houshmandi S Sean; Gutmann David H
All in the family: using inherited cancer syndromes to understand de-regulated cell signaling in brain tumors.
Journal of cellular biochemistry 2007;102(4):811-9.
2007: Zeng Ling-Hui; Ouyang Yannan; Gazit Vered; Cirrito John R; Jansen Laura A; Ess Kevin C; Yamada Kelvin A; Wozniak David F; Holtzman David M; Gutmann David H; Wong Michael
Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex.
Neurobiology of disease 2007;28(2):184-96.
2007: Hegedus Balazs; Dasgupta Biplab; Shin Jung Eun; Emnett Ryan J; Hart-Mahon Elizabeth K; Elghazi Lynda; Bernal-Mizrachi Ernesto; Gutmann David H
Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.
Cell stem cell 2007;1(4):443-57.
2007: Tang Xiaoling; Jang Sung-Wuk; Wang Xuerong; Liu Zhixue; Bahr Scott M; Sun Shi-Yong; Brat Daniel; Gutmann David H; Ye Keqiang
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
Nature cell biology 2007;9(10):1199-207.
2007: Warrington Nicole M; Woerner B Mark; Daginakatte Girish C; Dasgupta Biplab; Perry Arie; Gutmann David H; Rubin Joshua B
Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.
Cancer research 2007;67(18):8588-95.
2007: Maurel Patrice; Einheber Steven; Galinska Jolanta; Thaker Pratik; Lam Isabel; Rubin Marina B; Scherer Steven S; Murakami Yoshinuri; Gutmann David H; Salzer James L
Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
The Journal of cell biology 2007;178(5):861-74.
2007: Spinner Robert J; Scheithauer Bernd W; Perry Arie; Amrami Kimberly K; Emnett Ryan; Gutmann David H
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report.
Journal of neurosurgery 2007;107(2):435-9.
2007: Sandsmark D K; Pelletier C; Weber J D; Gutmann D H
Mammalian target of rapamycin: master regulator of cell growth in the nervous system.
Histology and histopathology 2007;22(8):895-903.
2007: Erbayat-Altay Ebru; Zeng Ling-Hui; Xu Lin; Gutmann David H; Wong Michael
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Epilepsia 2007;48(8):1470-6.
2007: Gilbertson Richard J; Gutmann David H
Tumorigenesis in the brain: location, location, location.
Cancer research 2007;67(12):5579-82.
2007: Sandsmark Danielle K; Zhang Huabiao; Hegedus Balazs; Pelletier Corey L; Weber Jason D; Gutmann David H
Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes.
Cancer research 2007;67(10):4790-9.
2007: Daginakatte Girish C; Gutmann David H
Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth.
Human molecular genetics 2007;16(9):1098-112.
2007: Banerjee Debasish; Hegedus Balazs; Gutmann David H; Garbow Joel R
Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivo.
NeuroImage 2007;35(4):1434-7.
2007: Su Weiping; Xing Rubing; Guha Abhijit; Gutmann David H; Sherman Larry S
Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging.
Glia 2007;55(7):723-33.
2007: Listernick Robert; Ferner Rosalie E; Liu Grant T; Gutmann David H
Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations.
Annals of neurology 2007;61(3):189-98.
2007: Pelletier Corey L; Maggi Leonard B; Brady Suzanne N; Scheidenhelm Danielle K; Gutmann David H; Weber Jason D
TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation.
Cancer research 2007;67(4):1609-17.
2007: Sharma Mukesh K; Mansur David B; Reifenberger Guido; Perry Arie; Leonard Jeffrey R; Aldape Kenneth D; Albin Meredith G; Emnett Ryan J; Loeser Simon; Watson Mark A; Nagarajan Rakesh; Gutmann David H
Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.
Cancer research 2007;67(3):890-900.
2006: Houshmandi S S; Surace E I; Zhang H B; Fuller G N; Gutmann D H
Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor.
Neurology 2006;67(10):1863-6.
2006: Surace Ezequiel I; Strickland Amy; Hess Rex A; Gutmann David H; Naughton Cathy K
Tslc1 (nectin-like molecule-2) is essential for spermatozoa motility and male fertility.
Journal of andrology 2006;27(6):816-25.
2006: Leonard J R; Perry A; Rubin J B; King A A; Chicoine M R; Gutmann D H
The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1.
Neurology 2006;67(8):1509-12.
2006: Wei Qingxia; Clarke Laura; Scheidenhelm Danielle K; Qian Baoping; Tong Amanda; Sabha Nesrin; Karim Zia; Bock Nicholas A; Reti Robert; Swoboda Rolf; Purev Enkhtsetseg; Lavoie Jean-Francois; Bajenaru M Livia; Shannon Patrick; Herlyn Dorothee; Kaplan David; Henkelman R Mark; Gutmann David H; Guha Abhijit
High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.
Cancer research 2006;66(15):7429-37.
2006: Read Tracy-Ann; Hegedus Balazs; Wechsler-Reya Robert; Gutmann David H
The neurobiology of neurooncology.
Annals of neurology 2006;60(1):3-11.
2006: Gerber Mark A; Bahr Scott M; Gutmann David H
Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling.
Cancer research 2006;66(10):5295-303.
2006: Gutmann David H; Hunter-Schaedle Kim; Shannon Kevin M
Harnessing preclinical mouse models to inform human clinical cancer trials.
The Journal of clinical investigation 2006;116(4):847-52.
2006: Chadee Deborah N; Xu Dazhong; Hung Gene; Andalibi Ali; Lim David J; Luo Zhijun; Gutmann David H; Kyriakis John M
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4463-8.
2006: Miller Shyra J; Rangwala Fatima; Williams Jon; Ackerman Peter; Kong Sue; Jegga Anil G; Kaiser Sergio; Aronow Bruce J; Frahm Silke; Kluwe Lan; Mautner Victor; Upadhyaya Meena; Muir David; Wallace Margaret; Hagen Jussara; Quelle Dawn E; Watson Mark A; Perry Arie; Gutmann David H; Ratner Nancy
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer research 2006;66(5):2584-91.
2006: Mangoura D; Sun Y; Li C; Singh D; Gutmann D H; Flores A; Ahmed M; Vallianatos G
Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells.
Oncogene 2006;25(5):735-45.
2006: Yamada Daisuke; Kikuchi Shinji; Williams Yuko N; Sakurai-Yageta Mika; Masuda Mari; Maruyama Tomoko; Tomita Kyoichi; Gutmann David H; Kakizoe Tadao; Kitamura Tadaichi; Kanai Yae; Murakami Yoshinori
Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.
International journal of cancer. Journal international du cancer 2006;118(4):916-23.
2006: Sharma M K; Watson M A; Lyman M; Perry A; Aldape K D; Deák F; Gutmann D H
Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma.
Neurology 2006;66(1):127-30.
2006: Gutmann David H; Maher Elizabeth A; Van Dyke Terry
Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors.
Cancer research 2006;66(1):10-3.
2005: Jansen Laura A; Uhlmann Erik J; Crino Peter B; Gutmann David H; Wong Michael
Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes.
Epilepsia 2005;46(12):1871-80.
2005: Mawrin Christian; Schulz Stefan; Hellwig-Patyk Anja; Kirches Elmar; Roessner Albert; Lendeckel Uwe; Firsching Raimund; Vorwerk Christian K; Keilhoff Gerburg; Dietzmann Knut; Grimm Kirsten; Lindberg Guy; Gutmann David H; Scheithauer Bernd W; Perry Arie
Expression and function of somatostatin receptors in peripheral nerve sheath tumors.
Journal of neuropathology and experimental neurology 2005;64(12):1080-8.
2005: Zhu Yuan; Harada Takayuki; Liu Li; Lush Mark E; Guignard Frantz; Harada Chikako; Burns Dennis K; Bajenaru M Livia; Gutmann David H; Parada Luis F
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.
Development (Cambridge, England) 2005;132(24):5577-88.
2005: Dasgupta Biplab; Yi Yijun; Hegedus Balazs; Weber Jason D; Gutmann David H
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Cancer research 2005;65(21):9843-50.
2005: Sharma Mukesh K; Zehnbauer Barbara A; Watson Mark A; Gutmann David H
RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma.
Neurology 2005;65(8):1335-6.
2005: Shannon Patrick; Sabha Nesrin; Lau Nelson; Kamnasaran Deepak; Gutmann David H; Guha Abhijit
Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model.
The American journal of pathology 2005;167(3):859-67.
2005: Scoles Daniel R; Qin Yun; Nguyen Vu; Gutmann David H; Pulst Stefan-M
HRS inhibits EGF receptor signaling in the RT4 rat schwannoma cell line.
Biochemical and biophysical research communications 2005;335(2):385-92.
2005: Kuns Robin; Kissil Joseph L; Newsham Irene F; Jacks Tyler; Gutmann David H; Sherman Larry S
Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation.
Oncogene 2005;24(43):6502-15.
2005: Lusis Eriks A; Watson Mark A; Chicoine Michael R; Lyman Meghan; Roerig Peter; Reifenberger Guido; Gutmann David H; Perry Arie
Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma.
Cancer research 2005;65(16):7121-6.
2005: Rubin Joshua B; Gutmann David H
Neurofibromatosis type 1 - a model for nervous system tumour formation?
Nature reviews. Cancer 2005;5(7):557-64.
2005: Yang Genyan; Khalaf Waleed; van de Locht Louis; Jansen Joop H; Gao Meihua; Thompson Mary Ann; van der Reijden Bert A; Gutmann David H; Delwel Ruud; Clapp D Wade; Hiebert Scott W
Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.
Molecular and cellular biology 2005;25(14):5869-79.
2005: Rajaram Veena; Gutmann David H; Prasad Srinivas K; Mansur David B; Perry Arie
Alterations of protein 4.1 family members in ependymomas: a study of 84 cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(7):991-7.
2005: Kabbarah Omar; Sotelo Andrea K; Mallon Mary Ann; Winkeler Erin L; Fan Ming-Yu; Pfeifer John D; Shibata Darryl; Gutmann David H; Goodfellow Paul J
Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice.
International journal of cancer. Journal international du cancer 2005;115(4):666-9.
2005: Dasgupta Biplab; Gutmann David H
Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5584-94.
2005: Perry Arie; Lusis Eriks A; Gutmann David H
Meningothelial hyperplasia: a detailed clinicopathologic, immunohistochemical and genetic study of 11 cases.
Brain pathology (Zurich, Switzerland) 2005;15(2):109-15.
2005: Ess Kevin C; Kamp Christine A; Tu Benjamin P; Gutmann David H
Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.
Neurology 2005;64(8):1446-9.
2005: Dasgupta Biplab; Yi Yijun; Chen David Y; Weber Jason D; Gutmann David H
Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors.
Cancer research 2005;65(7):2755-60.
2005: Scheidenhelm Danielle K; Cresswell Jennifer; Haipek Carrie A; Fleming Timothy P; Mercer Robert W; Gutmann David H
Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.
Molecular and cellular biology 2005;25(8):3151-62.
2005: Ward Beth Ann; Gutmann David H
Neurofibromatosis 1: from lab bench to clinic.
Pediatric neurology 2005;32(4):221-8.
2005: Robb Victoria A; Gerber Mark A; Hart-Mahon Elizabeth K; Gutmann David H
Membrane localization of the U2 domain of Protein 4.1B is necessary and sufficient for meningioma growth suppression.
Oncogene 2005;24(11):1946-57.
2005: Perry Arie; Kurtkaya-Yapicier Ozlem; Scheithauer Bernd W; Robinson Shenandoah; Prayson Richard A; Kleinschmidt-DeMasters B K; Stemmer-Rachamimov Anat O; Gutmann David H
Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature.
Brain pathology (Zurich, Switzerland) 2005;15(1):55-65.
2005: Dasgupta Biplab; Li Wen; Perry Arie; Gutmann David H
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Cancer research 2005;65(1):236-45.
2005: Bajenaru M Livia; Garbow Joel R; Perry Arie; Hernandez M Rosario; Gutmann David H
Natural history of neurofibromatosis 1-associated optic nerve glioma in mice.
Annals of neurology 2005;57(1):119-27.
2004: Rong Rong; Tang Xiaoling; Gutmann David H; Ye Keqiang
Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18200-5.
2004: Lusis Eriks; Gutmann David H
Meningioma: an update.
Current opinion in neurology 2004;17(6):687-92.
2004: Perry Arie; Gutmann David H; Reifenberger Guido
Molecular pathogenesis of meningiomas.
Journal of neuro-oncology 2004;70(2):183-202.
2004: Listernick R; Ferner R E; Piersall L; Sharif S; Gutmann D H; Charrow J
Late-onset optic pathway tumors in children with neurofibromatosis 1.
Neurology 2004;63(10):1944-6.
2004: Fraser Melissa M; Zhu Xiaoyan; Kwon Chang-Hyuk; Uhlmann Erik J; Gutmann David H; Baker Suzanne J
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo.
Cancer research 2004;64(21):7773-9.
2004: Rong Rong; Surace Ezequiel I; Haipek Carrie A; Gutmann David H; Ye Keqiang
Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression.
Oncogene 2004;23(52):8447-54.
2004: Surace Ezequiel I; Lusis Eriks; Murakami Yoshinori; Scheithauer Bernd W; Perry Arie; Gutmann David H
Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival.
Journal of neuropathology and experimental neurology 2004;63(10):1015-27.
2004: Singh Vinita; Miranda Tina Branscombe; Jiang Wei; Frankel Adam; Roemer Martha E; Robb Victoria A; Gutmann David H; Herschman Harvey R; Clarke Steven; Newsham Irene F
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Oncogene 2004;23(47):7761-71.
2004: Scheidenhelm Danielle K; Gutmann David H
Mouse models of tuberous sclerosis complex.
Journal of child neurology 2004;19(9):726-33.
2004: Maria Bernard L; Deidrick Kathleen McCann; Roach E Steve; Gutmann David H
Tuberous sclerosis complex: pathogenesis, diagnosis, strategies, therapies, and future research directions.
Journal of child neurology 2004;19(9):632-42.
2004: Fedi Marco; Anne Mitchell L; Kalnins Renate M; Gutmann David H; Perry Arie; Newton Mark; Brodtmann Amy; Berkovic Samuel F
Glioneuronal tumours in neurofibromatosis type 1: MRI-pathological study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2004;11(7):745-7.
2004: Surace Ezequiel I; Lusis Eriks; Haipek Carrie A; Gutmann David H
Functional significance of S6K overexpression in meningioma progression.
Annals of neurology 2004;56(2):295-8.
2004: Uhlmann Erik J; Li Wen; Scheidenhelm Danielle K; Gau Chia-Ling; Tamanoi Fuyuhiko; Gutmann David H
Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.
Glia 2004;47(2):180-8.
2004: Watson Mark A; Perry Arie; Tihan Tarik; Prayson Richard A; Guha Abhijit; Bridge Julia; Ferner Rosalie; Gutmann David H
Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors.
Brain pathology (Zurich, Switzerland) 2004;14(3):297-303.
2004: Robb Victoria A; Li Wen; Gutmann David H
Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression.
Oncogene 2004;23(20):3589-96.
2004: Arun Deepa; Gutmann David H
Recent advances in neurofibromatosis type 1.
Current opinion in neurology 2004;17(2):101-5.
2004: Ess Kevin C; Uhlmann Erik J; Li Wen; Li Hongzhen; Declue Jeffrey E; Crino Peter B; Gutmann David H
Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology.
Glia 2004;46(1):28-40.
2004: Chen Y; Gutmann D H; Haipek C A; Martinsen B J; Bronner-Fraser M; Krull C E
Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;229(3):541-54.
2004: Spritz Richard A; Itin Peter H; Gutmann David H
Piebaldism and neurofibromatosis type 1: horses of very different colors.
The Journal of investigative dermatology 2004;122(2):xxxiv-xxxv.
2004: Su Weiping; Gutmann David H; Perry Arie; Abounader Roger; Laterra John; Sherman Larry S
CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro.
Glia 2004;45(3):297-306.
2004: Surace Ezequiel I; Haipek Carrie A; Gutmann David H
Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.
Oncogene 2004;23(2):580-7.
2003: Bajenaru M Livia; Hernandez M Rosario; Perry Arie; Zhu Yuan; Parada Luis F; Garbow Joel R; Gutmann David H
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.
Cancer research 2003;63(24):8573-7.
2003: Oh Min-Kyu; Scoles Daniel R; Haipek Carrie; Strand Andrew D; Gutmann David H; Olson James M; Pulst Stefan-M
Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays.
Journal of cellular biochemistry 2003;90(5):1068-78.
2003: Gutmann D H; James C D; Poyhonen M; Louis D N; Ferner R; Guha A; Hariharan S; Viskochil D; Perry A
Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1.
Neurology 2003;61(10):1397-400.
2003: Maldonado Michelle; Baybis Marianna; Newman David; Kolson Dennis L; Chen Wei; McKhann Guy; Gutmann David H; Crino Peter B
Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex.
Neurobiology of disease 2003;14(2):279-90.
2003: Dasgupta Biplab; Dugan Laura L; Gutmann David H
The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8949-54.
2003: King Allison; Listernick Robert; Charrow Joel; Piersall Linda; Gutmann David H
Optic pathway gliomas in neurofibromatosis type 1: the effect of presenting symptoms on outcome.
American journal of medical genetics. Part A 2003;122A(2):95-9.
2003: Tabancay Angel P; Gau Chia-Ling; Machado Iara M P; Uhlmann Erik J; Gutmann David H; Guo Lea; Tamanoi Fuyuhiko
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.
The Journal of biological chemistry 2003;278(41):39921-30.
2003: Robb Victoria A; Li Wen; Gascard Philippe; Perry Arie; Mohandas Narla; Gutmann David H
Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis.
Neurobiology of disease 2003;13(3):191-202.
2003: Wong Michael; Ess Kevin C; Uhlmann Erik J; Jansen Laura A; Li Wen; Crino Peter B; Mennerick Steven; Yamada Kelvin A; Gutmann David H
Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.
Annals of neurology 2003;54(2):251-6.
2003: Gutmann D H; Winkeler E; Kabbarah O; Hedrick N; Dudley S; Goodfellow P J; Liskay R M
Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice.
Oncogene 2003;22(29):4581-5.
2003: Gutmann David H; Baker Suzanne J; Giovannini Marco; Garbow Joel; Weiss William
Mouse models of human cancer consortium symposium on nervous system tumors.
Cancer research 2003;63(11):3001-4.
2003: Huang Zhi-Yong; Wu YanLi; Burke Stephen P; Gutmann David H
The 43000 growth-associated protein functions as a negative growth regulator in glioma.
Cancer research 2003;63(11):2933-9.
2003: Apicelli Anthony J; Uhlmann Erik J; Baldwin Rebecca L; Ding Hao; Nagy Andras; Guha Abhijit; Gutmann David H
Role of the Rap1 GTPase in astrocyte growth regulation.
Glia 2003;42(3):225-34.
2003: Ding Hao; Shannon Patrick; Lau Nelson; Wu Xiaoli; Roncari Luba; Baldwin Rebecca L; Takebayashi Hirohide; Nagy Andras; Gutmann David H; Guha Abhijit
Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.
Cancer research 2003;63(5):1106-13.
2003: Dasgupta Biplab; Gutmann David H
Neurofibromatosis 1: closing the GAP between mice and men.
Current opinion in genetics & development 2003;13(1):20-7.
2003: Baser Michael E; R Evans D Gareth; Gutmann David H
Neurofibromatosis 2.
Current opinion in neurology 2003;16(1):27-33.
2003: Huang Zhi-yong; Wu YanLi; Hedrick Nicolé; Gutmann David H
T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression.
Molecular and cellular biology 2003;23(2):566-78.
2003: Lau Nelson; Uhlmann Erik J; Von Lintig Friederike C; Nagy Andras; Boss Gerry R; Gutmann David H; Guha Abhijit
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
International journal of oncology 2003;22(1):195-200.
2002: Scoles Daniel R; Nguyen Vu D; Qin Yun; Sun Chun-Xiao; Morrison Helen; Gutmann David H; Pulst Stefan-M
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling.
Human molecular genetics 2002;11(25):3179-89.
2002: Sun Chun-Xiao; Haipek Carrie; Scoles Daniel R; Pulst Stefan M; Giovannini Marco; Komada Masayuki; Gutmann David H
Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate.
Human molecular genetics 2002;11(25):3167-78.
2002: Sun Chun-Xiao; Robb Victoria A; Gutmann David H
Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation.
Journal of cell science 2002;115(Pt 21):3991-4000.
2002: Woods Stacey A; Marmor Eric; Feldkamp Matthias; Lau Nelson; Apicelli Anthony J; Boss Gerry; Gutmann David H; Guha Abhijit
Aberrant G protein signaling in nervous system tumors.
Journal of neurosurgery 2002;97(3):627-42.
2002: Gutmann D H; Rasmussen S A; Wolkenstein P; MacCollin M M; Guha A; Inskip P D; North K N; Poyhonen M; Birch P H; Friedman J M
Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1).
Neurology 2002;59(5):759-61.
2002: Chan Chi-Chao; Koch Christian A; Kaiser-Kupfer Muriel I; Parry Dilys M; Gutmann David H; Zhuang Zhengping; Vortmeyer Alexander O
Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2.
The Journal of pathology 2002;198(1):14-20.
2002: Uhlmann Erik J; Wong Michael; Baldwin Rebecca L; Bajenaru M Livia; Onda Hiroaki; Kwiatkowski David J; Yamada Kelvin; Gutmann David H
Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.
Annals of neurology 2002;52(3):285-96.
2002: Lynch Timothy M; Gutmann David H
Neurofibromatosis 1.
Neurologic clinics 2002;20(3):841-65.
2002: Gutmann David H
Neurofibromin in the brain.
Journal of child neurology 2002;17(8):592-601; discussion 602-4, 646-51.
2002: Watson Mark A; Gutmann David H; Peterson Kelly; Chicoine Michael R; Kleinschmidt-DeMasters Bette K; Brown Henry G; Perry Arie
Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays.
The American journal of pathology 2002;161(2):665-72.
2002: Perry Arie; Kunz Sarah N; Fuller Christine E; Banerjee Ruma; Marley Edith F; Liapis Helen; Watson Mark A; Gutmann David H
Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms.
Journal of neuropathology and experimental neurology 2002;61(8):702-9.
2002: Yu Tingxi; Robb Victoria A; Singh Vinita; Gutmann David H; Newsham Irene F
The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.
The Biochemical journal 2002;365(Pt 3):783-9.
2002: Baser M E; De Rienzo A; Altomare D; Balsara B R; Hedrick N M; Gutmann D H; Pitts L H; Jackler R K; Testa J R
Neurofibromatosis 2 and malignant mesothelioma.
Neurology 2002;59(2):290-1.
2002: Gutmann David H; Giovannini Marco
Mouse models of neurofibromatosis 1 and 2.
Neoplasia (New York, N.Y.) 2002;4(4):279-90.
2002: Bajenaru Michaela Livia; Zhu Yuan; Hedrick Nicolé M; Donahoe Jessica; Parada Luis F; Gutmann David H
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.
Molecular and cellular biology 2002;22(14):5100-13.
2002: Uhlmann Erik J; Apicelli Anthony J; Baldwin Rebecca L; Burke Stephen P; Bajenaru M Livia; Onda Hiroaki; Kwiatkowski David; Gutmann David H
Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
Oncogene 2002;21(25):4050-9.
2002: Friedman J M; Arbiser Jack; Epstein Jonathan A; Gutmann David H; Huot Stephen J; Lin Angela E; McManus Bruce; Korf Bruce R
Cardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force.
Genetics in medicine : official journal of the American College of Medical Genetics 2002;4(3):105-11.
2002: Packer R J; Gutmann D H; Rubenstein A; Viskochil D; Zimmerman R A; Vezina G; Small J; Korf B
Plexiform neurofibromas in NF1: toward biologic-based therapy.
Neurology 2002;58(10):1461-70.
2002: Singh Pratima K; Gutmann David H; Fuller Christine E; Newsham Irene F; Perry Arie
Differential involvement of protein 4.1 family members DAL-1 and NF2 in intracranial and intraspinal ependymomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2002;15(5):526-31.
2002: Kalamarides Michel; Niwa-Kawakita Michiko; Leblois Hélène; Abramowski Vincent; Perricaudet Michel; Janin Anne; Thomas Gilles; Gutmann David H; Giovannini Marco
Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse.
Genes & development 2002;16(9):1060-5.
2002: Gutmann David H; Hedrick Nicolé M; Li Jun; Nagarajan Rakesh; Perry Arie; Watson Mark A
Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas.
Cancer research 2002;62(7):2085-91.
2002: Ferner Rosalie E; Gutmann David H
International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis.
Cancer research 2002;62(5):1573-7.
2002: Gutmann David H; Huang Zhi-yong; Hedrick Nicolé M; Ding Hao; Guha Abhijit; Watson Mark A
Mouse glioma gene expression profiling identifies novel human glioma-associated genes.
Annals of neurology 2002;51(3):393-405.
2002: Huang Zhi-yong; Baldwin Rebecca L; Hedrick Nicolé M; Gutmann David H
Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo.
Oncogene 2002;21(9):1325-34.
2001: Gutmann D H; Wu Y L; Hedrick N M; Zhu Y; Guha A; Parada L F
Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes.
Human molecular genetics 2001;10(26):3009-16.
2001: Sherman L S; Gutmann D H
Merlin: hanging tumor suppression on the Rac.
Trends in cell biology 2001;11(11):442-4.
2001: Perry A; Giannini C; Raghavan R; Scheithauer B W; Banerjee R; Margraf L; Bowers D C; Lytle R A; Newsham I F; Gutmann D H
Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases.
Journal of neuropathology and experimental neurology 2001;60(10):994-1003.
2001: Kyin R; Hua Y; Baybis M; Scheithauer B; Kolson D; Uhlmann E; Gutmann D; Crino P B
Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex.
The American journal of pathology 2001;159(4):1541-54.
2001: Arbiser J L; Yeung R; Weiss S W; Arbiser Z K; Amin M B; Cohen C; Frank D; Mahajan S; Herron G S; Yang J; Onda H; Zhang H B; Bai X; Uhlmann E; Loehr A; Northrup H; Au P; Davis I; Fisher D E; Gutmann D H
The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms.
The American journal of pathology 2001;159(2):483-91.
2001: Listernick R; Charrow J; Gutmann D H
Comments on neurofibromatosis 1 and optic pathway tumors.
American journal of medical genetics 2001;102(1):105.
2001: Gutmann D H; Hirbe A C; Haipek C A
Functional analysis of neurofibromatosis 2 (NF2) missense mutations.
Human molecular genetics 2001;10(14):1519-29.
2001: Scherer S S; Xu T; Crino P; Arroyo E J; Gutmann D H
Ezrin, radixin, and moesin are components of Schwann cell microvilli.
Journal of neuroscience research 2001;65(2):150-64.
2001: Perry A; Roth K A; Banerjee R; Fuller C E; Gutmann D H
NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors.
The American journal of pathology 2001;159(1):57-61.
2001: MacCollin M; Gutmann D H; Korf B; Finkelstein R
Establishing priorities in neurofibromatosis research: a workshop summary.
Genetics in medicine : official journal of the American College of Medical Genetics 2001;3(3):212-7.
2001: Ding H; Roncari L; Shannon P; Wu X; Lau N; Karaskova J; Gutmann D H; Squire J A; Nagy A; Guha A
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.
Cancer research 2001;61(9):3826-36.
2001: Morrison H; Sherman L S; Legg J; Banine F; Isacke C; Haipek C A; Gutmann D H; Ponta H; Herrlich P
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.
Genes & development 2001;15(8):968-80.
2001: Gutmann D H; Hirbe A C; Huang Z Y; Haipek C A
The protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion.
Neurobiology of disease 2001;8(2):266-78.
2001: Li J; Perry A; James C D; Gutmann D H
Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas.
Neurology 2001;56(7):885-90.
2001: Reed N; Gutmann D H
Tumorigenesis in neurofibromatosis: new insights and potential therapies.
Trends in molecular medicine 2001;7(4):157-62.
2001: Gutmann D H; Haipek C A; Burke S P; Sun C X; Scoles D R; Pulst S M
The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility.
Human molecular genetics 2001;10(8):825-34.
2001: Gutmann D H
The neurofibromatoses: when less is more.
Human molecular genetics 2001;10(7):747-55.
2001: Bajenaru M L; Donahoe J; Corral T; Reilly K M; Brophy S; Pellicer A; Gutmann D H
Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes.
Glia 2001;33(4):314-23.
2001: Uhlmann E J; Gutmann D H
Tumor suppressor gene regulation of cell growth: recent insights into neurofibromatosis 1 and 2 gene function.
Cell biochemistry and biophysics 2001;34(1):61-78.
2000: Perry A; Cai D X; Scheithauer B W; Swanson P E; Lohse C M; Newsham I F; Weaver A; Gutmann D H
Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases.
Journal of neuropathology and experimental neurology 2000;59(10):872-9.
2000: Lau N; Feldkamp M M; Roncari L; Loehr A H; Shannon P; Gutmann D H; Guha A
Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.
Journal of neuropathology and experimental neurology 2000;59(9):759-67.
2000: King A A; Debaun M R; Riccardi V M; Gutmann D H
Malignant peripheral nerve sheath tumors in neurofibromatosis 1.
American journal of medical genetics 2000;93(5):388-92.
2000: Gutmann D H; Donahoe J; Brown T; James C D; Perry A
Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.
Neuropathology and applied neurobiology 2000;26(4):361-7.
2000: Scoles D R; Huynh D P; Chen M S; Burke S P; Gutmann D H; Pulst S M
The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.
Human molecular genetics 2000;9(11):1567-74.
2000: Lim D J; Rubenstein A E; Evans D G; Jacks T; Seizinger B G; Baser M E; Beebe D; Brackmann D E; Chiocca E A; Fehon R G; Giovannini M; Glazer R; Gusella J F; Gutmann D H; Korf B; Lieberman F; Martuza R; McClatchey A I; Parry D M; Pulst S M; Ramesh V; Ramsey W J; Ratner N; Rutkowski J L; Ruttledge M; Weinstein D E
Advances in neurofibromatosis 2 (NF2): a workshop report.
Journal of neurogenetics 2000;14(2):63-106.
2000: Gutmann D H; Donahoe J; Perry A; Lemke N; Gorse K; Kittiniyom K; Rempel S A; Gutierrez J A; Newsham I F
Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas.
Human molecular genetics 2000;9(10):1495-500.
2000: Waggoner D J; Towbin J; Gottesman G; Gutmann D H
Clinic-based study of plexiform neurofibromas in neurofibromatosis 1.
American journal of medical genetics 2000;92(2):132-5.
2000: Rutkowski J L; Wu K; Gutmann D H; Boyer P J; Legius E
Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1.
Human molecular genetics 2000;9(7):1059-66.
2000: Gutmann D H; Zhang Y; Hasbani M J; Goldberg M P; Plank T L; Petri Henske E
Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues.
Acta neuropathologica 2000;99(3):223-30.
2000: King A; Gutmann D H
The question of familial meningiomas and schwannomas: NF2B or not to be?
Neurology 2000;54(1):4-5.
1999: Gutmann D H; Haipek C A; Hoang Lu K
Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations.
Journal of neuroscience research 1999;58(5):706-16.
1999: Gutmann D H
Learning disabilities in neurofibromatosis 1: sizing up the brain.
Archives of neurology 1999;56(11):1322-3.
1999: Gutmann D H; Zhang Y; Hirbe A
Developmental regulation of a neuron-specific neurofibromatosis 1 isoform.
Annals of neurology 1999;46(5):777-82.
1999: Liapis H; Dehner L P; Gutmann D H
Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors.
The American journal of surgical pathology 1999;23(9):1156-8.
1999: Vogelbaum M A; Tong J X; Perugu R; Gutmann D H; Rich K M
Overexpression of bax in human glioma cell lines.
Journal of neurosurgery 1999;91(3):483-9.
1999: Dugan L L; Kim J S; Zhang Y; Bart R D; Sun Y; Holtzman D M; Gutmann D H
Differential effects of cAMP in neurons and astrocytes. Role of B-raf.
The Journal of biological chemistry 1999;274(36):25842-8.
1999: Strauss B L; Gutmann D H; Dehner L P; Hirbe A; Zhu X; Marley E F; Liapis H
Molecular analysis of malignant triton tumors.
Human pathology 1999;30(8):984-8.
1999: Gutmann D H; Loehr A; Zhang Y; Kim J; Henkemeyer M; Cashen A
Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation.
Oncogene 1999;18(31):4450-9.
1999: Listernick R; Charrow J; Gutmann D H
Intracranial gliomas in neurofibromatosis type 1.
American journal of medical genetics 1999;89(1):38-44.
1999: Hung G; Faudoa R; Li X; Xeu Z; Brackmann D E; Hitselberg W; Saleh E; Lee F; Gutmann D H; Slattery W; Rhim J S; Lim D
Establishment of primary vestibular schwannoma cultures from neurofibromatosis type-2 patients.
International journal of oncology 1999;14(3):409-15.
1999: Gutmann D H; Sherman L; Seftor L; Haipek C; Hoang Lu K; Hendrix M
Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.
Human molecular genetics 1999;8(2):267-75.
1998: Gutmann D H
Parallels between tuberous sclerosis complex and neurofibromatosis 1: common threads in the same tapestry.
Seminars in pediatric neurology 1998;5(4):276-86.
1998: Feldkamp M M; Gutmann D H; Guha A
Neurofibromatosis type 1: piecing the puzzle together.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1998;25(3):181-91.
1998: Gutmann D H
Recent insights into neurofibromatosis type 1: clear genetic progress.
Archives of neurology 1998;55(6):778-80.
1998: Gutmann D H; Geist R T; Xu H m; Kim J S; Saporito-Irwin S
Defects in neurofibromatosis 2 protein function can arise at multiple levels.
Human molecular genetics 1998;7(3):335-45.
1998: Xu H M; Gutmann D H
Merlin differentially associates with the microtubule and actin cytoskeleton.
Journal of neuroscience research 1998;51(3):403-15.
1998: Vogelbaum M A; Tong J X; Higashikubo R; Gutmann D H; Rich K M
Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside.
Journal of neurosurgery 1998;88(1):99-105.
1997: Vogelbaum M A; Tong J X; Higashikubo R; Gutmann D H; Rich K M
Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside.
Neurosurgical focus 1997;3(5):Article3.
1997: Sherman L; Xu H M; Geist R T; Saporito-Irwin S; Howells N; Ponta H; Herrlich P; Gutmann D H
Interdomain binding mediates tumor growth suppression by the NF2 gene product.
Oncogene 1997;15(20):2505-9.
1997: Gutmann D H; Saporito-Irwin S; DeClue J E; Wienecke R; Guha A
Alterations in the rap1 signaling pathway are common in human gliomas.
Oncogene 1997;15(13):1611-6.
1997: Saporito-Irwin S M; Geist R T; Gutmann D H
Ammonium acetate protocol for the preparation of plasmid DNA suitable for mammalian cell transfections.
BioTechniques 1997;23(3):424-7.
1997: Wienecke R; Guha A; Maize J C; Heideman R L; DeClue J E; Gutmann D H
Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas.
Annals of neurology 1997;42(2):230-5.
1997: Gutmann D H; Giordano M J; Fishback A S; Guha A
Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas.
Neurology 1997;49(1):267-70.
1997: Gutmann D H; Aylsworth A; Carey J C; Korf B; Marks J; Pyeritz R E; Rubenstein A; Viskochil D
The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2.
JAMA : the journal of the American Medical Association 1997;278(1):51-7.
1997: Xu H; Gutmann D H
Mutations in the GAP-related domain impair the ability of neurofibromin to associate with microtubules.
Brain research 1997;759(1):149-52.
1997: Listernick R; Louis D N; Packer R J; Gutmann D H
Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force.
Annals of neurology 1997;41(2):143-9.
1997: Gutmann D H
Molecular insights into neurofibromatosis 2.
Neurobiology of disease 1997;3(4):247-61.
1996: Scherer S S; Gutmann D H
Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells.
Journal of neuroscience research 1996;46(5):595-605.
1996: Gutmann D H; Gurney J G; Shannon K M
Juvenile xanthogranuloma, neurofibromatosis 1, and juvenile chronic myeloid leukemia.
Archives of dermatology 1996;132(11):1390-1.
1996: McDonald J W; Bautista R E; Gutmann D H
Pseudocervical cord syndrome: a deceptive flumazenil reversible manifestation of hepatic encephalopathy.
Archives of neurology 1996;53(10):956.
1996: Platten M; Giordano M J; Dirven C M; Gutmann D H; Louis D N
Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas.
The American journal of pathology 1996;149(2):621-7.
1996: Geist R T; Gutmann D H
Expression of a developmentally-regulated neuron-specific isoform of the neurofibromatosis 1 (NF1) gene.
Neuroscience letters 1996;211(2):85-8.
1996: Gutmann D H; Giordano M J; Mahadeo D K; Lau N; Silbergeld D; Guha A
Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.
Oncogene 1996;12(10):2121-7.
1996: Feldkamp M M; Lau N; Provias J P; Gutmann D H; Guha A
Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1: a pathological and molecular explanation. Case report.
Journal of neurosurgery 1996;84(5):867-73.
1996: Geist R T; Reddy A J; Zhang J; Gutmann D H
Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues.
Neurobiology of disease 1996;3(2):111-20.
1996: Guha A; Lau N; Huvar I; Gutmann D; Provias J; Pawson T; Boss G
Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.
Oncogene 1996;12(3):507-13.
1996: Giordano M J; Mahadeo D K; He Y Y; Geist R T; Hsu C; Gutmann D H
Increased expression of the neurofibromatosis 1 (NF1) gene product, neurofibromin, in astrocytes in response to cerebral ischemia.
Journal of neuroscience research 1996;43(2):246-53.
1996: Norton K K; Mahadeo D K; Geist R T; Gutmann D H
Expression of the neurofibromatosis 1 (NF1) gene during growth arrest.
Neuroreport 1996;7(2):601-4.
1995: Gutmann D H
Tumor suppressor genes as negative growth regulators in development and differentiation.
The International journal of developmental biology 1995;39(6):895-908.
1995: Geist R T; Gutmann D H
The tuberous sclerosis 2 gene is expressed at high levels in the cerebellum and developing spinal cord.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1477-83.
1995: Norton K K; Carey J C; Gutmann D H
Oculodentodigital dysplasia with cerebral white matter abnormalities in a two-generation family.
American journal of medical genetics 1995;57(3):458-61.
1995: Hewett S J; Choi D W; Gutmann D H
Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro.
Neuroreport 1995;6(11):1565-8.
1995: Gutmann D H; Geist R T; Rose K; Wallin G; Moley J F
Loss of neurofibromatosis type I (NF1) gene expression in pheochromocytomas from patients without NF1.
Genes, chromosomes & cancer 1995;13(2):104-9.
1995: Gutmann D H; Wright D E; Geist R T; Snider W D
Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development.
Human molecular genetics 1995;4(3):471-8.
1995: Gutmann D H; Geist R T; Wright D E; Snider W D
Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(3):315-23.
1995: Gutmann D H; Geist R T; Rose K; Wright D E
Expression of two new protein isoforms of the neurofibromatosis type 1 gene product, neurofibromin, in muscle tissues.
Developmental dynamics : an official publication of the American Association of Anatomists 1995;202(3):302-11.
1995: Norton K K; Xu J; Gutmann D H
Expression of the neurofibromatosis I gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle.
Neurobiology of disease 1995;2(1):13-21.
1995: Gutmann D H; Silos-Santiago I; Geist R T; Daras M; Rutkowski J L
Lack of NF1 expression in a sporadic schwannoma from a patient without neurofibromatosis.
Journal of neuro-oncology 1995;25(2):103-11.
1995: Gutmann D H; Cole J L; Collins F S
Expression of the neurofibromatosis type 1 (NF1) gene during mouse embryonic development.
Progress in brain research 1995;105():327-35.
1994: Yousem D M; Gutmann D H; Lenkinski R
Limitations of magnetic resonance spectroscopy in patients with white matter disease.
Annals of neurology 1994;36(6):932-3.
1994: Gutmann D H; Cole J L; Stone W J; Ponder B A; Collins F S
Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type I.
Genes, chromosomes & cancer 1994;10(1):55-8.
1994: Gutmann D H
New insights into the neurofibromatoses.
Current opinion in neurology 1994;7(2):166-71.
1994: Nakamura T; Nemoto T; Arai M; Yamazaki Y; Kasuga T; Gutmann D H; Collins F S; Ishikawa T
Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.
The American journal of pathology 1994;144(3):549-55.
1994: Boyer M J; Gutmann D H; Collins F S; Bar-Sagi D
Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP.
Oncogene 1994;9(2):349-57.
1994: Gutmann D H; Cole J L; Collins F S
Modulation of neurofibromatosis type 1 gene expression during in vitro myoblast differentiation.
Journal of neuroscience research 1994;37(3):398-405.
1993: Gutmann D H; Collins F S
Neurofibromatosis type 1. Beyond positional cloning.
Archives of neurology 1993;50(11):1185-93.
1993: Gutmann D H; Tennekoon G I; Cole J L; Collins F S; Rutkowski J L
Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation.
Journal of neuroscience research 1993;36(2):216-23.
1993: Gregory P E; Gutmann D H; Mitchell A; Park S; Boguski M; Jacks T; Wood D L; Jove R; Collins F S
Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules.
Somatic cell and molecular genetics 1993;19(3):265-74.
1993: Gutmann D H; Collins F S
The neurofibromatosis type 1 gene and its protein product, neurofibromin.
Neuron 1993;10(3):335-43.
1993: Gutmann D H; Boguski M; Marchuk D; Wigler M; Collins F S; Ballester R
Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.
Oncogene 1993;8(3):761-9.
1993: Andersen L B; Fountain J W; Gutmann D H; Tarlé S A; Glover T W; Dracopoli N C; Housman D E; Collins F S
Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines.
Nature genetics 1993;3(2):118-21.
1993: Andersen L B; Ballester R; Marchuk D A; Chang E; Gutmann D H; Saulino A M; Camonis J; Wigler M; Collins F S
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
Molecular and cellular biology 1993;13(1):487-95.
1992: Gutmann D H; Collins F S
Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis.
Annals of neurology 1992;31(5):555-61.
1992: Basu T N; Gutmann D H; Fletcher J A; Glover T W; Collins F S; Downward J
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients.
Nature 1992;356(6371):713-5.
1991: Gutmann D H; Marino P L
An alternative apnea test for the evaluation of brain death.
Annals of neurology 1991;30(6):852-3.
1991: Marchuk D A; Saulino A M; Tavakkol R; Swaroop M; Wallace M R; Andersen L B; Mitchell A L; Gutmann D H; Boguski M; Collins F S
cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product.
Genomics 1991;11(4):931-40.
1991: Gutmann D H; Wood D L; Collins F S
Identification of the neurofibromatosis type 1 gene product.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9658-62.
1991: Gutmann D H; Zackai E H; McDonald-McGinn D M; Fischbeck K H; Kamholz J
Oculodentodigital dysplasia syndrome associated with abnormal cerebral white matter.
American journal of medical genetics 1991;41(1):18-20.
1991: Yousem D M; Gutmann D H; Milestone B N; Lenkinski R E
Integrated MR imaging and proton nuclear magnetic resonance spectroscopy in a family with an X-linked spastic paraparesis.
AJNR. American journal of neuroradiology 1991;12(4):785-9.
1991: Gutmann D H
Chromosome 11q23.3-qter deletion and Alexander disease.
American journal of medical genetics 1991;39(2):226-7.
1991: Gutmann D H; Brooks M L; Emanuel B S; McDonald-McGinn D M; Zackai E H
Congenital nystagmus in a (46,XX/45,X) mosaic woman from a family with X-linked congenital nystagmus.
American journal of medical genetics 1991;39(2):167-9.
1990: Gutmann D H; Cantor C R; Piacente G J; McCluskey L F
Cerebral vasculopathy and infarction in a woman with carcinomatous meningitis.
Journal of neuro-oncology 1990;9(2):183-5.
1990: Gutmann D H; Fischbeck K H; Kamholz J
Complicated hereditary spastic paraparesis with cerebral white matter lesions.
American journal of medical genetics 1990;36(2):251-7.
1990: Gutmann D H; Grossman R I; Mollman J E
Personality changes associated with thalamic infiltration.
Journal of neuro-oncology 1990;8(3):263-7.
1989: Gutmann D H; Scherer S
Magnetic resonance imaging of ataxic hemiparesis localized to the corona radiata.
Stroke; a journal of cerebral circulation 1989;20(11):1571-3.
1989: Gutmann D H; Fischbeck K H; Sergott R C
Hereditary retinal vasculopathy with cerebral white matter lesions.
American journal of medical genetics 1989;34(2):217-20.
1989: Raps E C; Gutmann D H; Brorson J R; O'Connor M; Hurtig H I
Symptomatic hydrocephalus and reversible spinal cord compression in Listeria monocytogenes meningitis. Case report.
Journal of neurosurgery 1989;71(4):620-2.
1989: Gutmann D H; Fischbeck K H
Molecular biology of Duchenne and Becker's muscular dystrophy: clinical applications.
Annals of neurology 1989;26(2):189-94.
1988: Gutmann D H; Beard B A; Collinge M L
Nonfatal disseminated mucocutaneous herpes simplex type 2 infection in a healthy woman.
Obstetrics and gynecology 1988;72(3 Pt 2):506-8.
1985: Gutmann D H; Niederhuber J E
Separation of the immune response genes for LDH-B and MOPC-173. III. Evidence that the failure of B10.BASR1 to respond to LDH-B is due to an antigen-presenting cell defect.
Transplantation 1985;40(5):556-62.
1985: Gutmann D H; Niederhuber J E
Major histocompatibility complex regulation of the immune response.
The Journal of surgical research 1985;39(2):172-81.
1984: Schook L B; Gutmann D H; Marlin L E; Niederhuber J E
In-vitro-derived bone marrow macrophages. Expression of Ia antigens during macrophage differentiation.
Transplantation 1984;37(6):585-90.
1984: Gutmann D H; Niederhuber J E
Separation of the immune response genes for LDH-B and MOPC-173. II. Description of an immune response defect in B10.ASR7.
Journal of immunology (Baltimore, Md. : 1950) 1984;132(4):1955-9.
1984: Allen P M; Gutmann D H; Sher M R; Niederhuber J E
Characterization of three new intra-I region recombinant mouse strains, B10.ASR7 (H-2as3), B10.BAR4 (H-2h6), and B10.BASR1 (H-2as4).
Immunogenetics 1984;19(2):175-8.
1983: Gutmann D H; Allen P M; Niederhuber J E
Separation of the immune response genes for LDH-B and MOPC-173. I. Description of an immune response defect in B10.BASR1.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(6):2919-23.
1983: Gutmann D H
Restriction endonucleases.
The American journal of medical technology 1983;49(1):60.
1982: Schook L B; Bingham E L; Gutmann D H; Niederhuber J E
Characterization and expression of H-21 region gene products on bone marrow-derived macrophages.
European journal of immunology 1982;12(12):991-7.
1982: Gutmann D H
The use of restriction endonucleases in the prenatal diagnosis of hemoglobinopathies.
The American journal of medical technology 1982;48(5):361-6.
1982: Schook L B; Gutmann D H; Niederhuber J E
Characterization of bone marrow derived macrophage as Ia-bearing accessory cells.
Advances in experimental medicine and biology 1982;149():429-33.

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