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Mark Guttman

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Janet Williams; Anthony L Vaccarino; Nancy Downing; Mark Guttman; Jane S Paulsen
Self Reports of Day-to-Day Function in a Small Cohort of People with Prodromal and Early HD.
Stephen J Kish; Jason Lerch; Yoshiaki Furukawa; Junchao Tong; Tina McCluskey; Diana Wilkins; Sylvain Houle; Jeffrey Meyer; Emanuela Mundo; Alan Wilson; Pablo Rusjan; Jean A Saint-Cyr; Mark Guttman; D Louis Collins; Colin Shapiro; Jerry J Warsh; Isabelle Boileau
Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.
Isabelle Boileau; Mark Guttman; Pablo Rusjan; John R Adams; Sylvain Houle; Junchao Tong; Oleh Hornykiewicz; Yoshiaki Furukawa; Alan Wilson; Shitij Kapur; Stephen J Kish
Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease.

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All Publications

2011: Janet Williams; Anthony L Vaccarino; Nancy Downing; Mark Guttman; Jane S Paulsen
Self Reports of Day-to-Day Function in a Small Cohort of People with Prodromal and Early HD.
PLoS currents 2011;3():RRN1254.
2010: Stephen J Kish; Jason Lerch; Yoshiaki Furukawa; Junchao Tong; Tina McCluskey; Diana Wilkins; Sylvain Houle; Jeffrey Meyer; Emanuela Mundo; Alan Wilson; Pablo Rusjan; Jean A Saint-Cyr; Mark Guttman; D Louis Collins; Colin Shapiro; Jerry J Warsh; Isabelle Boileau
Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.
Brain : a journal of neurology 2010;133(Pt 6):1779-97.
2009: Isabelle Boileau; Mark Guttman; Pablo Rusjan; John R Adams; Sylvain Houle; Junchao Tong; Oleh Hornykiewicz; Yoshiaki Furukawa; Alan Wilson; Shitij Kapur; Stephen J Kish
Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease.
Brain : a journal of neurology 2009;132(Pt 5):1366-75.
2008: Isabelle Boileau; Pablo Rusjan; Sylvain Houle; Diana Wilkins; Junchao Tong; Peter Selby; Mark Guttman; Jean A Saint-Cyr; Alan Wilson; Stephen J Kish
Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(39):9850-6.
2008: Isabelle Boileau; Jerry J Warsh; Mark Guttman; Jean A Saint-Cyr; Tina McCluskey; Pablo Rusjan; Sylvain Houle; Alan Wilson; Jeffrey H Meyer; Stephen J Kish
Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB.
Movement disorders : official journal of the Movement Disorder Society 2008;23(12):1776-80.
2008: Jane S Paulsen; Douglas R Langbehn; Julie C Stout; Elizabeth H Aylward; Christopher A Ross; Martha Nance; Mark Guttman; S Johnson; Marcy E MacDonald; Leigh J Beglinger; Kevin Duff; Elise Kayson; K Biglan; Ira Shoulson; David Oakes; Michael R Hayden
Detection of Huntington's disease decades before diagnosis: the Predict-HD study.
Journal of neurology, neurosurgery, and psychiatry 2008;79(8):874-80.
2008: Yvonne Bombard; Elizabeth Penziner; Oksana Suchowersky; Mark Guttman; Jane S Paulsen; Joan L Bottorff; Michael R Hayden
Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease.
European journal of human genetics : EJHG 2008;16(3):279-89.
2008: Stephen J Kish; Junchao Tong; Oleh Hornykiewicz; Ali H Rajput; Li-Jan Chang; Mark Guttman; Yoshiaki Furukawa
Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease.
Brain : a journal of neurology 2008;131(Pt 1):120-31.
2007: Shannon A Johnson; Julie C Stout; Andrea C Solomon; Douglas R Langbehn; Elizabeth H Aylward; Christina B Cruce; Christopher A Ross; Martha Nance; Elise Kayson; Elaine Julian-Baros; Michael R Hayden; Karl Kieburtz; Mark Guttman; David Oakes; Ira Shoulson; Leigh J Beglinger; Kevin Duff; Elizabeth Penziner; Jane S Paulsen
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease.
Brain : a journal of neurology 2007;130(Pt 7):1732-44.
2007: Andrea C Solomon; Julie C Stout; Shannon A Johnson; Douglas R Langbehn; Elizabeth H Aylward; Jason Brandt; Christopher A Ross; Leigh J Beglinger; Michael R Hayden; Karl Kieburtz; Elise Kayson; Elaine Julian-Baros; Kevin Duff; Mark Guttman; Martha Nance; David Oakes; Ira Shoulson; Elizabeth Penziner; Jane S Paulsen
Verbal episodic memory declines prior to diagnosis in Huntington's disease.
Neuropsychologia 2007;45(8):1767-76.
2007: Jennifer E Tobin; Jing Cui; Jemma B Wilk; Jeanne C Latourelle; Jason M Laramie; Ann McKee; Mark Guttman; Samer Karamohamed; Anita L DeStefano; Richard H Myers
Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.
Brain research 2007;1139():42-7.
2007: Yvonne Bombard; Elizabeth Penziner; J Decolongon; M L N Klimek; Susan Creighton; Oksana Suchowersky; Mark Guttman; Jane S Paulsen; J L Bottorff; Michael R Hayden
Managing genetic discrimination: strategies used by individuals found to have the Huntington disease mutation.
Clinical genetics 2007;71(3):220-31.
2006: Jane S Paulsen; Michael R Hayden; Julie C Stout; Douglas R Langbehn; Elizabeth H Aylward; Christopher A Ross; Mark Guttman; Martha Nance; Karl Kieburtz; David Oakes; Ira Shoulson; Elise Kayson; Shannon Johnson; Elizabeth Penziner
Preparing for preventive clinical trials: the Predict-HD study.
Archives of neurology 2006;63(6):883-90.
2005: Mark Stacy; Annette Bowron; Mark Guttman; Robert A Hauser; Kim Hughes; Jan Petter Larsen; Peter LeWitt; Wolfgang H Oertel; Niall Quinn; Kapil D Sethi; Fabrizio Stocchi
Identification of motor and nonmotor wearing-off in Parkinson's disease: comparison of a patient questionnaire versus a clinician assessment.
Movement disorders : official journal of the Movement Disorder Society 2005;20(6):726-33.
2004: C Warren Olanow; Yves Agid; Yoshikuni Mizuno; Alberto Albanese; Ubaldo Bonuccelli; U Bonucelli; Philippe Damier; Justo De Yebenes; Oscar S Gershanik; Mark Guttman; Francisco Grandas; Mark Hallett; Oleh Hornykiewicz; Peter Jenner; Regina Katzenschlager; William J Langston; Peter LeWitt; Eldad Melamed; M A Mena; Patrick P Michel; Catherine Mytilineou; Jose A Obeso; Werner Poewe; Niall Quinn; Rita Raisman-Vozari; Ali H Rajput; Olivier Rascol; Cristina Sampaio; Fabrizio Stocchi
Levodopa in the treatment of Parkinson's disease: current controversies.
Movement disorders : official journal of the Movement Disorder Society 2004;19(9):997-1005.
2004: Mark Guttman; Pamela M Slaughter; Marc-Erick Theriault; Donald P DeBoer; C David Naylor
Parkinsonism in Ontario: comorbidity associated with hospitalization in a large cohort.
Movement disorders : official journal of the Movement Disorder Society 2004;19(1):49-53.
2004: Junchao Tong; Paul S Fitzmaurice; Lee Cyn Ang; Yoshiaki Furukawa; Mark Guttman; Stephen J Kish
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Annals of neurology 2004;55(1):125-9.
2003: Paul S Fitzmaurice; Lee Ang; Mark Guttman; Ali H Rajput; Yoshiaki Furukawa; Stephen J Kish
Nigral glutathione deficiency is not specific for idiopathic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2003;18(9):969-76.
2003: Yoshiaki Furukawa; Mark Guttman; Henry Wong; S A Farrell; Sarah Furtado; Stephen J Kish
Serum prolactin in symptomatic and asymptomatic dopa-responsive dystonia due to a GCH1 mutation.
Neurology 2003;61(2):269-70.
2003: Raúl de La Fuente-Fernández; Sarah Furtado; Mark Guttman; Yoshiaki Furukawa; Chong S Lee; Donald B Calne; Thomas J Ruth; A Jon Stoessl
VMAT2 binding is elevated in dopa-responsive dystonia: visualizing empty vesicles by PET.
Synapse (New York, N.Y.) 2003;49(1):20-8.
2003: Mark Guttman; Pamela M Slaughter; Marc-Erick Theriault; Donald P DeBoer; C David Naylor
Burden of parkinsonism: a population-based study.
Movement disorders : official journal of the Movement Disorder Society 2003;18(3):313-9.
2003: Mark Guttman; Stephen J Kish; Yoshiaki Furukawa
Current concepts in the diagnosis and management of Parkinson's disease.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2003;168(3):293-301.
2002: Mark Guttman; Pamela M Slaughter; Marc-Erick Theriault; Donald P DeBoer; C David Naylor
Parkinsonism in Ontario: physician utilization.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2002;29(3):221-6.
2002: Paul S Fitzmaurice; C L Bamsey; Lee Ang; Mark Guttman; Ali H Rajput; Yoshiaki Furukawa; Stephen J Kish
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Neurology 2002;59(1):137-8.
2002: Yoshiaki Furukawa; Sophie Vigouroux; Henry Wong; Mark Guttman; Ali H Rajput; Lee Ang; Marièle Briand; Stephen J Kish; Yves Briand
Brain proteasomal function in sporadic Parkinson's disease and related disorders.
Annals of neurology 2002;51(6):779-82.
2002: NE Maher; Lawrence I Golbe; Alice Lazzarini; Margery H Mark; Lillian J Currie; G Frederick Wooten; Marie H Saint-Hilaire; Jemma B Wilk; Jeannine Volcjak; J E Maher; Robert G Feldman; Mark Guttman; Mark Lew; C H Waters; S Schuman; Oksana Suchowersky; Anne-Louise Lafontaine; Nancy Labelle; Peter Vieregge; P P Pramstaller; Christine Klein; Jean P Hubble; C Reider; John H Growdon; Ray L Watts; E Montgomery; K Baker; Carlos Singer; Mark Stacy; Richard H Myers
Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study.
Neurology 2002;58(1):79-84.
2001: Mark Guttman; Pamela M Slaughter; Marc-Erick Theriault; Donald P DeBoer; C David Naylor
Parkinsonism in Ontario: increased mortality compared with controls in a large cohort study.
Neurology 2001;57(12):2278-82.
2001: Anita L DeStefano; Lawrence I Golbe; Margery H Mark; Alice Lazzarini; NE Maher; Marie H Saint-Hilaire; Robert G Feldman; Mark Guttman; Ray L Watts; Oksana Suchowersky; Anne-Louise Lafontaine; Nancy Labelle; Mark Lew; C H Waters; John H Growdon; Carlos Singer; Lillian J Currie; G Frederick Wooten; Peter Vieregge; P P Pramstaller; Christine Klein; Jean P Hubble; Mark Stacy; E Montgomery; Marcy E MacDonald; James Gusella; Richard H Myers
Genome-wide scan for Parkinson's disease: the GenePD Study.
Neurology 2001;57(6):1124-6.
2001: Jane S Paulsen; H Zhao; Julie C Stout; Ryan R Brinkman; Mark Guttman; Christopher A Ross; Peter G Como; C Manning; Michael R Hayden; Ira Shoulson
Clinical markers of early disease in persons near onset of Huntington's disease.
Neurology 2001;57(4):658-62.
2001: Stephen J Kish; Kathryn S Kalasinsky; Gregory A Schmunk; Yoshiaki Furukawa; Mark Guttman; Lee Ang
Dopaminergic changes in human brain following acute exposure to gamma-hydroxybutyrate.
Neurology 2001;56(11):1602-3.
2001: Mark Guttman; D Stewart; D Hussey; A Wilson; S Houle; Stephen J Kish
Influence of L-dopa and pramipexole on striatal dopamine transporter in early PD.
Neurology 2001;56(11):1559-64.
2001: Stephen J Kish; Kathryn S Kalasinsky; P Derkach; Gregory A Schmunk; Mark Guttman; Lee Ang; Vernard Adams; Yoshiaki Furukawa; John W Haycock
Striatal dopaminergic and serotonergic markers in human heroin users.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(5):561-7.
2001: Kathryn S Kalasinsky; Thomas Z Bosy; Gregory A Schmunk; G Reiber; R M Anthony; Yoshiaki Furukawa; Mark Guttman; Stephen J Kish
Regional distribution of methamphetamine in autopsied brain of chronic human methamphetamine users.
Forensic science international 2001;116(2-3):163-9.
2000: J N Worsley; Anna Moszczynska; P Falardeau; Kathryn S Kalasinsky; Gregory A Schmunk; Mark Guttman; Yoshiaki Furukawa; Lee Ang; Vernard Adams; G Reiber; R A Anthony; Dennis J Wickham; Stephen J Kish
Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users.
Molecular psychiatry 2000;5(6):664-72.
2000: Kathryn S Kalasinsky; Thomas Z Bosy; Gregory A Schmunk; Lee Ang; Vernard Adams; S B Gore; John E Smialek; Yoshiaki Furukawa; Mark Guttman; Stephen J Kish
Regional distribution of cocaine in postmortem brain of chronic human cocaine users.
Journal of forensic sciences 2000;45(5):1041-8.
2000: Yoshiaki Furukawa; Mark Guttman; S P Sparagana; JM Trugman; Keith Hyland; P Wyatt; Anthony E Lang; G A Rouleau; M Shimadzu; Stephen J Kish
Dopa-responsive dystonia due to a large deletion in the GTP cyclohydrolase I gene.
Annals of neurology 2000;47(4):517-20.
1999: Mark Guttman; Oksana Suchowersky
Parkinson's disease management: towards a new paradigm.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1999;26 Suppl 2():S53-7.
1999: Stephen J Kish; F Mastrogiacomo; Mark Guttman; Yoshiaki Furukawa; J W Taanman; S Dozić; Massimo Pandolfo; JB Lamarche; L DiStefano; Li-Jan Chang
Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?
Journal of neurochemistry 1999;72(2):700-7.
1999: Stephen J Kish; Kathryn S Kalasinsky; Yoshiaki Furukawa; Mark Guttman; Lee Ang; Ling Li; Vernard Adams; G Reiber; R A Anthony; W Anderson; John E Smialek; L DiStefano
Brain choline acetyltransferase activity in chronic, human users of cocaine, methamphetamine, and heroin.
Molecular psychiatry 1999;4(1):26-32.
1998: Stephen J Kish; I Lopes-Cendes; Mark Guttman; Yoshiaki Furukawa; Massimo Pandolfo; G A Rouleau; Brian M Ross; Martha Nance; Lawrence J Schut; Lee Ang; L DiStefano
Brain glyceraldehyde-3-phosphate dehydrogenase activity in human trinucleotide repeat disorders.
Archives of neurology 1998;55(10):1299-304.
1998: Yoshiaki Furukawa; Anthony E Lang; JM Trugman; Thomas D Bird; A Hunter; M Sadeh; T Tagawa; Peter St George-Hyslop; Mark Guttman; L W Morris; Oleh Hornykiewicz; M Shimadzu; Stephen J Kish
Gender-related penetrance and de novo GTP-cyclohydrolase I gene mutations in dopa-responsive dystonia.
Neurology 1998;50(4):1015-20.
1997: Mark Guttman
Double-blind comparison of pramipexole and bromocriptine treatment with placebo in advanced Parkinson's disease. International Pramipexole-Bromocriptine Study Group.
Neurology 1997;49(4):1060-5.
1997: Mark Guttman; J Burkholder; Stephen J Kish; D Hussey; A Wilson; Jean N DaSilva; S Houle
[11C]RTI-32 PET studies of the dopamine transporter in early dopa-naive Parkinson's disease: implications for the symptomatic threshold.
Neurology 1997;48(6):1578-83.
1997: Stephen J Kish; Mark Guttman; Y Robitaille; M el-Awar; Li-Jan Chang; Allan Levey
Striatal dopamine nerve terminal markers but not nigral cellularity are reduced in spinocerebellar ataxia type 1.
Neurology 1997;48(4):1109-11.
1996: J M Wilson; Allan Levey; Alex Rajput; Lee Ang; Mark Guttman; K Shannak; Hyman B Niznik; Oleh Hornykiewicz; C Pifl; Stephen J Kish
Differential changes in neurochemical markers of striatal dopamine nerve terminals in idiopathic Parkinson's disease.
Neurology 1996;47(3):718-26.