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Denis Guttridge

Research Profile

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TOP 3
Kenneth C H Fearon; David J Glass; Denis C Guttridge
Cancer cachexia: mediators, signaling, and metabolic pathways.
Jeremy S Tilstra; Arvydas Usas; Nam Vo; Jin Wang; Yinsheng Wang; Simon C Watkins; Andria R Robinson; Claudette M St Croix; Donna B Stolz; Cheryl L Clauson; Paula R Clemens; George A Garinis; Siobhán Q Gregg; Denis C Guttridge; Johnny Huard; Luigi A Nasto; Laura J Niedernhofer; Daniel P Reay; Paul D Robbins
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
Aiping Lu; Laura J Niedernhofer; Jonathan D Proto; Paul D Robbins; Ying Tang; Jeremy S Tilstra; Bing Wang; Lulin Guo; Denis C Guttridge; Mitra Lavasani; Johnny Huard
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.

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All Publications

2012: Kenneth C H Fearon; David J Glass; Denis C Guttridge
Cancer cachexia: mediators, signaling, and metabolic pathways.
Cell metabolism 2012;16(2):153-66.
2012: Jeremy S Tilstra; Arvydas Usas; Nam Vo; Jin Wang; Yinsheng Wang; Simon C Watkins; Andria R Robinson; Claudette M St Croix; Donna B Stolz; Cheryl L Clauson; Paula R Clemens; George A Garinis; Siobhán Q Gregg; Denis C Guttridge; Johnny Huard; Luigi A Nasto; Laura J Niedernhofer; Daniel P Reay; Paul D Robbins
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
The Journal of clinical investigation 2012;122(7):2601-12.
2012: Aiping Lu; Laura J Niedernhofer; Jonathan D Proto; Paul D Robbins; Ying Tang; Jeremy S Tilstra; Bing Wang; Lulin Guo; Denis C Guttridge; Mitra Lavasani; Johnny Huard
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(3):661-8.
2012: Nadine Bakkar; Naresh C Bal; Benjamin D Canan; Paul Janssen; Katherine J Ladner; Qiutang Li; Sandya Liyanarachchi; Meghna Pant; Muthu Periasamy; Denis C Guttridge
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
The Journal of cell biology 2012;196(4):497-511.
2012: Maura H Parker; Julia von Maltzahn; Ban Al-Joubori; Nadine Bakkar; Denis C Guttridge; Jeff Ishibashi; Michael A Rudnicki
MyoD-dependent regulation of NF-κB activity couples cell-cycle withdrawal to myogenic differentiation.
Skeletal muscle 2012;2(1):6.
2012: Jason M Dahlman; Denis C Guttridge
Detection of NF-κB activity in skeletal muscle cells by electrophoretic mobility shift analysis.
Methods in molecular biology (Clifton, N.J.) 2012;798():505-16.
2011: Daniel P Reay; Khaleel K Rehman; Paul D Robbins; Jon F Watchko; Michele Yang; Monica J Daood; Denis C Guttridge; Terrence L O'Day; Paula R Clemens
Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.
Neurobiology of disease 2011;43(3):598-608.
2011: Bethany L Mundy-Bosse; Gregory Young; Kristen Benninger; Abhik Ray Chaudhury; Kristan Guenterberg; Denis C Guttridge; Alena C Jaime-Ramirez; Mahmood Khan; Sri Vidya Kondadasula; Melanie Kreiner; Periannan Kuppusamy; Krista M La Perle; Gregory B Lesinski; William E Carson
Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice.
Cancer research 2011;71(15):5101-10.
2011: Tohru Hosoyama; Jinu Abraham; Mohammed Imran Aslam; Denis C Guttridge; Joel Michalek; Laura D Nelon; Koichi Nishijo; Suresh Prajapati; Brian P Rubin; Lee Ann Zarzabal; Charles Keller
IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2757-66.
2011: Jennifer M Peterson; Jill A Rafael-Fortney; Daniel J Ricca; Paul D Robbins; Brian Kaspar; Pravin Kaumaya; William Kline; Joe N Kornegay; Jerry R Mendell; Albert S Baldwin; Benjamin D Canan; Paula R Clemens; Dawn A Delfín; Kelly DiRienzo; Pat Flood; Michael Freitas; Denis C Guttridge; Paul Janssen
Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):508-15.
2011: Denis C Guttridge
Making muscles grow by g protein-coupled receptor signaling.
Science signaling 2011;4(201):pe45.
2011: Dalia H A Abdelaziz; Basant A Abdulrahman; Anwari Akhter; Simranjit S Bedi; Kyle Caution; Andrea I Doseff; Fathia Z El-Sharkawi; Mikhail Gavrilin; M. Elba Gonzalez-Mejia; Denis C Guttridge; Zeinab A Hassan; Thirumala-Devi Kanneganti; Arwa Abu Khweek; Sheetal Kotrange; Katherine J Ladner; Clay B Marsh; Mahmoud Mostafa; Mark D Wewers; Amal O Amer
Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages.
Frontiers in microbiology 2011;2():18.
2011: Scott Shadfar; Lisa J Weinstein; Xiaoying Yin; Marion E Couch; Denis C Guttridge; Kibwei A McKinney; Jessica E Rodríguez; Monte Willis
Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo.
Nutrition and cancer 2011;63(5):749-62.
2011: Jennifer M Peterson; Nadine Bakkar; Denis C Guttridge
NF-κB signaling in skeletal muscle health and disease.
Current topics in developmental biology 2011;96():85-119.
2011: Dawn A Delfín; Denis C Guttridge; Jennifer M Peterson; Jill A Rafael-Fortney; Ying Xu; Paul Janssen
Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy.
Journal of translational medicine 2011;9():68.
2010: Shengying Bao; Ming-Jie Liu; Bryan Lee; Beth Besecker; Ju-Ping Lai; Denis C Guttridge; Daren L Knoell
Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB.
American journal of physiology. Lung cellular and molecular physiology 2010;298(6):L744-54.
2010: Nadine Bakkar; Denis C Guttridge
NF-kappaB signaling: a tale of two pathways in skeletal myogenesis.
Physiological reviews 2010;90(2):495-511.
2010: Richard J E Skipworth; Grant D Stewart; Mishaim Bhana; Jennifer Christie; Catharine M Sturgeon; Denis C Guttridge; Andrew D Cronshaw; Kenneth C H Fearon; James A Ross
Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine.
International journal of oncology 2010;36(4):973-82.
2010: Jason M Dahlman; Nadine Bakkar; Wei He; Denis C Guttridge
NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development.
The Journal of biological chemistry 2010;285(8):5479-87.
2010: Swarnali Acharyya; Sudarshana M Sharma; Alfred S L Cheng; Katherine J Ladner; Wei He; William Kline; Huating Wang; Michael C Ostrowski; Hui-Ming (Tim) Huang; Denis C Guttridge
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.
PloS one 2010;5(8):e12479.
2010: Nathan A Stephens; Iain J Gallagher; Olav Rooyackers; Richard J E Skipworth; Ben H Tan; Troels Marstrand; James A Ross; Denis C Guttridge; Lars Lundell; Kenneth C H Fearon; James A Timmons
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia.
Genome medicine 2010;2(1):1.
2009: Jingxin Wang; Naduparambil K Jacob; Katherine J Ladner; Amer A Beg; James D Perko; Stephan M Tanner; Sandya Liyanarachchi; Richard Fishel; Denis C Guttridge
RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair.
EMBO reports 2009;10(11):1272-8.
2009: shih-shih chen; Aparna Raval; Amy J Johnson; Erin Hertlein; Te-Hui Liu; Victor X Jin; Mara H Sherman; Shu-Jun Liu; David W Dawson; Katie E Williams; Mark Lanasa; Sandya Liyanarachchi; Thomas S Lin; Guido Marcucci; yuri pekarsky; Ramana V Davuluri; Carlo M Croce; Denis C Guttridge; Michael A Teitell; John C Byrd; Christoph Plass
Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13433-8.
2009: Eri Taniguchi; Min Jung Cho; Benjamin R Arenkiel; Mark S Hansen; Omar J Rivera; Amanda T McCleish; Stephen J Qualman; Denis C Guttridge; Matthew P Scott; Mario R Capecchi; Charles Keller
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.
Pediatric blood & cancer 2009;53(2):136-44.
2009: Huating Wang; Hao Sun; Denis C Guttridge
microRNAs: novel components in a muscle gene regulatory network.
Cell cycle (Georgetown, Tex.) 2009;8(12):1833-7.
2009: Raquel M Raices; Yashaswini Kannan; Vedavathi Bellamkonda-Athmaram; Sudarshan Seshadri; Huating Wang; Denis C Guttridge; Mark D Wewers
A novel role for IkappaBzeta in the regulation of IFNgamma production.
PloS one 2009;4(8):e6776.
2009: Jason M Dahlman; Jingxin Wang; Nadine Bakkar; Denis C Guttridge
The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis.
Journal of cellular biochemistry 2009;106(1):42-51.
2008: Huating Wang; Ramiro Garzon; Hao Sun; Katherine J Ladner; Ravi Singh; Jason Dahlman; Alfred Cheng; Brett M Hall; Stephen J Qualman; Dawn Chandler; Carlo M Croce; Denis C Guttridge
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.
Cancer cell 2008;14(5):369-81.
2008: Gregory B Lesinski; Ene T Raig; Kristan Guenterberg; Lloyd Brown; Michael R Go; Nisha N Shah; Adrian Lewis; Megan Quimper; Erinn Hade; Gregory Young; Abhik Ray Chaudhury; Katherine J Ladner; Denis C Guttridge; Page Bouchard; William E Carson
IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis.
Cancer research 2008;68(20):8351-60.
2008: Louise Y Y Fong; Yubao Jiang; Maurisa Riley; Xianglan Liu; Karl J. Smalley; Denis C Guttridge; John L Farber
Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2.
International journal of cancer. Journal international du cancer 2008;122(5):978-89.
2008: Trinitia Cannon; Carol G Shores; Xiaoying Yin; Jason Dahlman; Denis C Guttridge; Victor Lai; Jonathan George; Petra Buzkova; Marion Couch
Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma.
Head & neck 2008;30(3):320-6.
2008: Nadine Bakkar; Jingxin Wang; Katherine J Ladner; Huating Wang; Jason M Dahlman; Micheal Carathers; Swarnali Acharyya; Michael A Rudnicki; Andrew D Hollenbach; Denis C Guttridge
IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis.
The Journal of cell biology 2008;180(4):787-802.
2008: W James Waldman; Marshall V Williams; Stanley Lemeshow; Philip Binkley; Denis C Guttridge; Janice K Kiecolt-Glaser; Deborah A Knight; Katherine J Ladner; Ronald Glaser
Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk.
Brain, behavior, and immunity 2008;22(2):215-23.
2008: Jennifer M Peterson; Denis C Guttridge
Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention.
International reviews of immunology 2008;27(5):375-87.
2007: Trinitia Y Cannon; Denis C Guttridge; Jason Dahlman; Jonathan R George; Victor Lai; Carol G Shores; Petra Buzková; Marion Couch
The effect of altered Toll-like receptor 4 signaling on cancer cachexia.
Archives of otolaryngology--head & neck surgery 2007;133(12):1263-9.
2007: Trinitia Cannon; Marion Couch; Xiaoying Yin; Denis C Guttridge; Victor Lai; Carol G Shores
Comparison of animal models for head and neck cancer cachexia.
The Laryngoscope 2007;117(12):2152-8.
2007: Courtney Nicholas; SANJAY BATRA; Melissa A Vargo; Oliver H Voss; Mikhail Gavrilin; Mark D Wewers; Denis C Guttridge; Erich Grotewold; Andrea I Doseff
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7121-7.
2007: Shashi Madhavan; Mirela Anghelina; Danen Sjostrom; Anar Dossumbekova; Denis C Guttridge; Sudha Agarwal
Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6246-54.
2007: M V P Nadella; Wessel P Dirksen; Kiran S Nadella; S Shu; Alfred S L Cheng; J A Morgenstern; Virgile Richard; Soledad A Fernandez; Hui-Ming (Tim) Huang; Denis C Guttridge; Thomas J Rosol
Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma.
Leukemia 2007;21(8):1752-62.
2007: Huating Wang; Erin Hertlein; Nadine Bakkar; Hao Sun; Swarnali Acharyya; Jingxin Wang; Micheal Carathers; Ramana V Davuluri; Denis C Guttridge
NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes.
Molecular and cellular biology 2007;27(12):4374-87.
2007: Jonathan George; Trinitia Cannon; Victor Lai; Luke M Richey; Adam M Zanation; David Hayes; Carol G Shores; Denis C Guttridge; Marion Couch
Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology.
Head & neck 2007;29(5):497-507.
2007: Swarnali Acharyya; S Armando Villalta; Nadine Bakkar; Tepmanas Bupha-Intr; Paul Janssen; Micheal Carathers; Zhi-Wei Li; Amer A Beg; Sankar Ghosh; Zarife Sahenk; Michael Weinstein; Katherine L Gardner; Jill A Rafael-Fortney; Michael Karin; James G Tidball; Albert S Baldwin; Denis C Guttridge
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
The Journal of clinical investigation 2007;117(4):889-901.
2007: Marion Couch; Victor Lai; Trinitia Cannon; Denis C Guttridge; Adam M Zanation; Jonathan George; David Hayes; Steven H Zeisel; Carol G Shores
Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment.
Head & neck 2007;29(4):401-11.
2007: Swarnali Acharyya; Denis C Guttridge
Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1356-61.
2006: Richard J E Skipworth; Grant Stewart; James A Ross; Denis C Guttridge; Kenneth C H Fearon
The molecular mechanisms of skeletal muscle wasting: implications for therapy.
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 2006;4(5):273-83.
2006: J Paul Monk; Gary Phillips; Ross Waite; John Kuhn; Larry J Schaaf; Gregory A Otterson; Denis C Guttridge; Chris A Rhoades; Manisha Shah; Tamara Criswell; Michael A Caligiuri; Miguel A Villalona-Calero
Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(12):1852-9.
2006: Anasuya Sarkar; Michelle Duncan; Judy Hart; Erin Hertlein; Denis C Guttridge; Mark D Wewers
ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4979-86.
2005: Swarnali Acharyya; Matthew E R Butchbach; Zarife Sahenk; Huating Wang; Motoyasu Saji; Micheal Carathers; Matthew D Ringel; Richard J E Skipworth; Kenneth C H Fearon; Michael A Hollingsworth; Peter Muscarella; Arthur H M Burghes; Jill A Rafael-Fortney; Denis C Guttridge
Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.
Cancer cell 2005;8(5):421-32.
2005: Erin Hertlein; Jingxin Wang; Katherine J Ladner; Nadine Bakkar; Denis C Guttridge
RelA/p65 regulation of IkappaBbeta.
Molecular and cellular biology 2005;25(12):4956-68.
2004: Swarnali Acharyya; Katherine J Ladner; Lori L Nelsen; Jeffrey Damrauer; Peter J Reiser; Steven Swoap; Denis C Guttridge
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.
The Journal of clinical investigation 2004;114(3):370-8.
2004: Matthew G Hartman; Dan Lu; Mi-Lyang Kim; Gary J Kociba; Tala Shukri; Jean Buteau; Xiaozhong Wang; Wendy L Frankel; Denis C Guttridge; Marc Prentki; Shane T Grey; David Ron; Tsonwin Hai
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis.
Molecular and cellular biology 2004;24(13):5721-32.
2004: Denis C Guttridge
Signaling pathways weigh in on decisions to make or break skeletal muscle.
Current opinion in clinical nutrition and metabolic care 2004;7(4):443-50.
2003: Patricia C Cogswell; David Kashatus; Jayne A Keifer; Denis C Guttridge; Julie Y Reuther; Cindy Bristow; Sophie Roy; Donald W Nicholson; Albert S Baldwin
NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B.
The Journal of biological chemistry 2003;278(5):2963-8.
2003: Katherine J Ladner; Michael A Caligiuri; Denis C Guttridge
Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products.
The Journal of biological chemistry 2003;278(4):2294-303.
2002: Zongbing You; Daniel Saims; Shaoqiong Chen; Zhaocheng Zhang; Denis C Guttridge; Kun-Liang Guan; Ormond A MacDougald; Anthony M C Brown; Gerard Evan; Jan Kitajewski; Cun-Yu Wang
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.
The Journal of cell biology 2002;157(3):429-40.
2001: Shiming Chen; Denis C Guttridge; Eric D Tang; Songtao Shi; Kunliang Guan; Cun-Yu Wang
Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling.
The Journal of biological chemistry 2001;276(42):39259-63.
2001: J A Keifer; Denis C Guttridge; BP Ashburner; Albert S Baldwin
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity.
The Journal of biological chemistry 2001;276(25):22382-7.
2001: Shiming Chen; Denis C Guttridge; Zongbing You; Zhaocheng Zhang; Andrew Fribley; Marty W Mayo; Jan Kitajewski; Cun-Yu Wang
Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription.
The Journal of cell biology 2001;152(1):87-96.
2000: Denis C Guttridge; Marty W Mayo; Lee V Madrid; Cun-Yu Wang; Albert S Baldwin
NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.
Science (New York, N.Y.) 2000;289(5488):2363-6.
2000: Lee V Madrid; Cun-Yu Wang; Denis C Guttridge; Arndt Schottelius; Albert S Baldwin; Marty W Mayo
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.
Molecular and cellular biology 2000;20(5):1626-38.
2000: Patricia C Cogswell; Denis C Guttridge; William K Funkhouser; Albert S Baldwin
Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3.
Oncogene 2000;19(9):1123-31.
1999: C Y Wang; Denis C Guttridge; Marty W Mayo; Albert S Baldwin
NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis.
Molecular and cellular biology 1999;19(9):5923-9.
1999: R K Batra; Denis C Guttridge; David A Brenner; S M Dubinett; Albert S Baldwin; Richard C Boucher
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
American journal of respiratory cell and molecular biology 1999;21(2):238-45.
1999: Denis C Guttridge; C Albanese; Julie Y Reuther; R G Pestell; Albert S Baldwin
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
Molecular and cellular biology 1999;19(8):5785-99.