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Kiplin Guy

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Jong Yeon Hwang; Marcel Kaiser; David Smithson; Fangyi Zhu; Reto Brun; MC Connelly; Gloria Holbrook; R Kiplin Guy
Optimization of Chloronitrobenzamides (CNBs) as Therapeutic Leads for Human African Trypanosomiasis (HAT).
Jong Yeon Hwang; Ramy R Attia; Angela K Carrillo; MC Connelly; R Kiplin Guy
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.
Liying Zhang; Hao Zhu; Julie Clark; MC Connelly; Sean Ekins; Denis Fourches; Alexander Golbraikh; Armand Guiguemde; R Kiplin Guy; Dena Hodges; Alexander Sedykh; Martina Sigal; Alexander Tropsha
Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening.

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All Publications

2013: Jong Yeon Hwang; Marcel Kaiser; David Smithson; Fangyi Zhu; Reto Brun; MC Connelly; Gloria Holbrook; R Kiplin Guy
Optimization of Chloronitrobenzamides (CNBs) as Therapeutic Leads for Human African Trypanosomiasis (HAT).
Journal of medicinal chemistry 2013;56(7):2850-60.
2013: Jong Yeon Hwang; Ramy R Attia; Angela K Carrillo; MC Connelly; R Kiplin Guy
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.
Bioorganic & medicinal chemistry letters 2013;23(6):1891-5.
2013: Liying Zhang; Hao Zhu; Julie Clark; MC Connelly; Sean Ekins; Denis Fourches; Alexander Golbraikh; Armand Guiguemde; R Kiplin Guy; Dena Hodges; Alexander Sedykh; Martina Sigal; Alexander Tropsha
Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening.
Journal of chemical information and modeling 2013;53(2):475-92.
2012: David Lowes; Jon Mirsalis; Toufan Parman; Anupam Pradhan; Martina Sigal; Liang Tang; Emily Wilson; Fangyi Zhu; Julie A Clark; MC Connelly; Joe L DeRisi; Anna Furimsky; Jason Gow; W Armand Guiguemde; Lalitha V Iyer; Dennis E Kyle; Andrew S Lemoff; R Kiplin Guy
Lead optimization of antimalarial propafenone analogues.
Journal of medicinal chemistry 2012;55(13):6087-93.
2012: W Armand Guiguemde; R Kiplin Guy
An all-purpose antimalarial drug target.
Cell host & microbe 2012;11(6):555-7.
2012: Premchendar Nandhikonda; Dana Pearson; Nina Y Yuan; Tahniyath Ara; Athena M Baranowski; Daniel D Bikle; R Kiplin Guy; Wen Z Lynt; Megan M McCallum; Leggy A Arnold
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.
Journal of medicinal chemistry 2012;55(10):4640-51.
2012: Yiqun Zhang; Fangyi Zhu; Julie A Clark; MC Connelly; Farah El Mazouni; Anna Furimsky; Jason Gow; W Armand Guiguemde; Lalitha Iyer; Dennis E Kyle; Jaeki Min; Jon Mirsalis; Toufan Parman; Margaret A Phillips; Anupam Pradhan; R Kiplin Guy
Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.
Journal of medicinal chemistry 2012;55(9):4205-19.
2012: Jong Yeon Hwang; Cynthia Jeffries; Andrew S Lemoff; Lei Yang; Fangyi Zhu; Ramy R Attia; MC Connelly; R Kiplin Guy
Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.
Journal of medicinal chemistry 2012;55(5):2301-10.
2012: W Armand Guiguemde; Thierry T Diagana; Francisco-Javier Gamo; Jose F Garcia-Bustos; Anang A Shelat; R Kiplin Guy
Global phenotypic screening for antimalarials.
Chemistry & biology 2012;19(1):116-29.
2012: Michal Bista; Grzegorz Dubin; Michael A Dyer; Kristin Finch; Sylwia Kedracka-Krok; Jaeki Min; Aleksandra Pecak; Artur Pirog; Katarzyna Pustelny; Gabriella Salinas; David Smithson; Brett Waddell; Benedykt Wladyka; Michal Zdzalik; R Kiplin Guy
On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53.
PloS one 2012;7(6):e37518.
2011: David J Lowes; Martina S Sigal; Emily B Wilson; Fangyi Zhu; Julie A Clark; MC Connelly; Joe L DeRisi; W Armand Guiguemde; Andrew S Lemoff; R Kiplin Guy
Optimization of propafenone analogues as antimalarial leads.
Journal of medicinal chemistry 2011;54(21):7477-85.
2011: Jong Yeon Hwang; Takashi Kawasuji; David J Lowes; Martina S Sigal; Emily B Wilson; Fangyi Zhu; Julie A Clark; MC Connelly; Joseph L Derisi; W Armand Guiguemde; R Kiplin Guy
Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.
Journal of medicinal chemistry 2011;54(20):7084-93.
2011: Prabodh Sadana; Leggy Arnold; Ramy R Attia; Jong Yeon Hwang; Geoffrey Neale; R Kiplin Guy
Similarities and differences between two modes of antagonism of the thyroid hormone receptor.
ACS chemical biology 2011;6(10):1096-106.
2011: Jennifer M Atkinson; Nidal Boulos; Angel Montero Carcaboso; Chris Eden; David W Ellison; Clementine Féau; Amar Gajjar; Paul Gibson; R Kiplin Guy; Robert A Johnson; Dimpy Koul; Tanya A Kranenburg; Kumarasamypet M Mohankumar; Timothy Phoenix; Helen M Poppleton; Waldemar Priebe; Anang A Shelat; Clinton F Stewart; Yiai Tong; Karen Wright; W K Alfred Yung; Liqin Zhu; Leggy Arnold; Richard J Gilbertson
An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.
Cancer cell 2011;20(3):384-99.
2011: Johanny Tonos De Leon; Clementine Feau; Robert J Fletterick; Yenni Garcia; Kristine Garza; R Kiplin Guy; Aki Iwai; Sunmin Lee; Leonard M Neckers; Yang-Min Ning; Daniel L Riggs; Cheryl L Storer; Raquel M Suro; Jane B Trepel; Yeong Sang Kim; Heather A Balsiger; Yu Chen; Marc Cox
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):11878-83.
2011: Ronald L Johnson; Jennifer Wichterman; Jong Yeon Hwang; James Inglese; Leggy Arnold; Indre Augustinaite; Christopher P Austin; R Kiplin Guy; Ruili Huang; Wenwei Huang
A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2.
Journal of biomolecular screening 2011;16(6):618-27.
2011: Jong Yeon Hwang; Wenwei Huang; Leggy Arnold; Ruili Huang; Ramy R Attia; Michele Connelly; Jennifer Wichterman; Fangyi Zhu; Indre Augustinaite; Christopher P Austin; James Inglese; Ronald L Johnson; R Kiplin Guy
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.
The Journal of biological chemistry 2011;286(14):11895-908.
2011: Clémentine Féau; Leggy Arnold; Aaron Kosinski; R Kiplin Guy
Ligand competition binding assay for the androgen receptor.
Methods in molecular biology (Clifton, N.J.) 2011;776():59-68.
2011: Fan Zhang; Michael Tagen; Stacy Throm; Jeremy Mallari; Laura Miller; R Kiplin Guy; Michael A Dyer; Richard T Williams; Martine F Roussel; Katie Nemeth; Fangyi Zhu; Jiakun Zhang; Min Lu; John C Panetta; Nidal Boulos; Clinton F Stewart
Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):15-21.
2010: Jeremy P Mallari; Fangyi Zhu; Andrew Lemoff; Marcel Kaiser; Min Lu; Reto Brun; R Kiplin Guy
Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.
Bioorganic & medicinal chemistry 2010;18(23):8302-9.
2010: David Smithson; Jeongmi Lee; Anang A Shelat; Margaret A Phillips; R Kiplin Guy
Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase.
The Journal of biological chemistry 2010;285(22):16771-81.
2010: Sunetra Ray; Peter B Madrid; Paul Catz; Susanna E LeValley; MJ Furniss; Linda L Rausch; R Kiplin Guy; Joseph L DeRisi; Lalitha V Iyer; Carol E Green; Jon C Mirsalis
Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.
Journal of medicinal chemistry 2010;53(9):3685-95.
2010: Damon Reed; Ying Shen; Anang A Shelat; Leggy A Arnold; Antonio M Ferreira; Fangyi Zhu; Nicholas Mills; David Smithson; Catherine A Regni; Donald Bashford; Samantha A. Cicero; Brenda A Schulman; Aart G Jochemsen; R Kiplin Guy; Michael A Dyer
Identification and characterization of the first small molecule inhibitor of MDMX.
The Journal of biological chemistry 2010;285(14):10786-96.
2010: Yiqun Zhang; W Armand Guiguemde; Martina Sigal; Fangyi Zhu; MC Connelly; Solomon Nwaka; R Kiplin Guy
Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.
Bioorganic & medicinal chemistry 2010;18(7):2756-66.
2010: David Smithson; Anang A Shelat; Jeffrey Baldwin; Margaret A Phillips; R Kiplin Guy
Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.
Assay and drug development technologies 2010;8(2):175-85.
2010: Md Jashim Uddin; David Smithson; Kristin M Brown; Brenda C Crews; Michele Connelly; Fangyi Zhu; Lawrence J Marnett; R Kiplin Guy
Podophyllotoxin analogues active versus Trypanosoma brucei.
Bioorganic & medicinal chemistry letters 2010;20(5):1787-91.
2009: Jeremy P Mallari; Anang A Shelat; Aaron Kosinski; Conor R Caffrey; Michele Connelly; Fangyi Zhu; James H McKerrow; R Kiplin Guy
Structure-guided development of selective TbcatB inhibitors.
Journal of medicinal chemistry 2009;52(20):6489-93.
2009: Clémentine Féau; leggy arnold; Aaron Kosinski; Fangyi Zhu; Michele Connelly; R Kiplin Guy
Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription.
ACS chemical biology 2009;4(10):834-43.
2009: Tina Shahian; Gregory M Lee; Ana Lazic; Leggy Arnold; Priya Velusamy; Christina M Roels; R Kiplin Guy; Charles S Craik
Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Nature chemical biology 2009;5(9):640-6.
2009: Jong Yeon Hwang; Leggy Arnold; Fangyi Zhu; Aaron Kosinski; Thomas J Mangano; Vincent Setola; Bryan L Roth; R Kiplin Guy
Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.
Journal of medicinal chemistry 2009;52(13):3892-901.
2009: Jeremy P Mallari; Wendyam A Guiguemde; R Kiplin Guy
Antimalarial activity of thiosemicarbazones and purine derived nitriles.
Bioorganic & medicinal chemistry letters 2009;19(13):3546-9.
2009: Jeremy O Jones; Eric C Bolton; Yong Huang; Clementine Feau; R Kiplin Guy; Keith R Yamamoto; Byron Hann; Marc I Diamond
Non-competitive androgen receptor inhibition in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7233-8.
2009: Arnaud Teichert; Leggy Arnold; Steve Otieno; Yuko Oda; Indre Augustinaite; Tim R Geistlinger; Richard W Kriwacki; R Kiplin Guy; Daniel David Bikle
Quantification of the vitamin D receptor-coregulator interaction.
Biochemistry 2009;48(7):1454-61.
2009: Anang A Shelat; R Kiplin Guy
A road less traveled by: exploring a decade of Ellman chemistry.
Bioorganic & medicinal chemistry 2009;17(3):1088-93.
2009: Clémentine Féau; Leggy Arnold; Aaron Kosinski; R Kiplin Guy
A high-throughput ligand competition binding assay for the androgen receptor and other nuclear receptors.
Journal of biomolecular screening 2009;14(1):43-8.
2008: Leggy Arnold; Patricia Ranaivo; R Kiplin Guy
Synthesis and characterization of BODIPY-labeled colchicine.
Bioorganic & medicinal chemistry letters 2008;18(22):5867-70.
2008: Jeremy P Mallari; Anang A Shelat; Aaron Kosinski; Conor R Caffrey; Michele Connelly; Fangyi Zhu; James H McKerrow; R Kiplin Guy
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Bioorganic & medicinal chemistry letters 2008;18(9):2883-5.
2008: Xin Guo; Pradipta Bandyopadhyay; Birgit Schilling; Malin M Young; Naoaki Fujii; Tiba Aynechi; R Kiplin Guy; Irwin D Kuntz; Bradford W Gibson
Partial acetylation of lysine residues improves intraprotein cross-linking.
Analytical chemistry 2008;80(4):951-60.
2008: Jeremy P Mallari; Anang A Shelat; Terri Obrien; Conor R Caffrey; Aaron Kosinski; Michele Connelly; Michael Harbut; Doron C Greenbaum; James H McKerrow; R Kiplin Guy
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
Journal of medicinal chemistry 2008;51(3):545-52.
2007: Eva Estébanez-Perpiñá; Leggy Arnold; Natalia Jouravel; Marie Togashi; Justin Blethrow; Ellena Mar; Phuong Nguyen; Kevin J Phillips; John D Baxter; Paul Webb; R Kiplin Guy; Robert J Fletterick
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):2919-28.
2007: Janice L Hyatt; Randy M Wadkins; Lyudmila Tsurkan; Latorya D Hicks; M Jason Hatfield; Carol C Edwards; Charles R Ross; Stephanie A Cantalupo; Guy Crundwell; Mary K Danks; R Kiplin Guy; Philip Potter
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Journal of medicinal chemistry 2007;50(23):5727-34.
2007: Natalia Jouravel; Elena P Sablin; Leggy Arnold; R Kiplin Guy; Robert J Fletterick
Interaction between the androgen receptor and a segment of its corepressor SHP.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1198-200.
2007: Leggy Arnold; Aaron Kosinski; Eva Estébanez-Perpiñá; Robert J Fletterick; R Kiplin Guy
Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.
Journal of medicinal chemistry 2007;50(22):5269-80.
2007: Eva Estébanez-Perpiñá; Leggy Arnold; Alexander A Arnold; Phuong Nguyen; Edson Delgado Rodrigues; Ellena Mar; Raynard Bateman; Peter Pallai; Kevan M Shokat; John D Baxter; R Kiplin Guy; Paul Webb; Robert J Fletterick
A surface on the androgen receptor that allosterically regulates coactivator binding.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16074-9.
2007: Nicholas L Mills; Anang A Shelat; R Kiplin Guy
Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen.
Journal of biomolecular screening 2007;12(7):946-55.
2007: Anang A Shelat; R Kiplin Guy
Scaffold composition and biological relevance of screening libraries.
Nature chemical biology 2007;3(8):442-6.
2007: James Inglese; Caroline E Shamu; R Kiplin Guy
Reporting data from high-throughput screening of small-molecule libraries.
Nature chemical biology 2007;3(8):438-41.
2007: david charles warhurst; John C Craig; Ipemida S Adagu; R Kiplin Guy; Peter B Madrid; Quinton L Fivelman
Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.
Biochemical pharmacology 2007;73(12):1910-26.
2007: Anang A Shelat; R Kiplin Guy
The interdependence between screening methods and screening libraries.
Current opinion in chemical biology 2007;11(3):244-51.
2007: Naoaki Fujii; Liang You; Zhidong Xu; Kazutsugu Uematsu; Jufang Shan; Biao He; Iwao Mikami; Lillian R Edmondson; Geoffrey Neale; Jie Zheng; R Kiplin Guy; David M Jablons
An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.
Cancer research 2007;67(2):573-9.
2007: Naoaki Fujii; Anang A Shelat; Randy A Hall; R Kiplin Guy
Design of a selective chemical probe for class I PDZ domains.
Bioorganic & medicinal chemistry letters 2007;17(2):546-8.
2007: Naoaki Fujii; Jose J Haresco; Kathleen A P Novak; Robert M Gage; Nicoletta Pedemonte; David Stokoe; Irwin D Kuntz; R Kiplin Guy
Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.
Bioorganic & medicinal chemistry letters 2007;17(2):549-52.
2006: Jonathan Gray; Stacy L Donovan; Chie-Schin Shih; Jiakun Zhang; Nicholas Mills; Christine Fuller; Amina Teunisse; Suzanne Lam; Yolande Ramos; Adithi Mohan; Dianna Johnson; Matthew Wilson; Carlos Rodriguez-Galindo; Micaela Quarto; Sarah Francoz; Susan Mendrysa; R Kiplin Guy; Jean-Christophe Marine; Aart G Jochemsen; Michael A Dyer
Inactivation of the p53 pathway in retinoblastoma.
Nature 2006;444(7115):61-6.
2006: Barnaby C H May; Juanita Witkop; John Sherrill; Marc O Anderson; Peter B Madrid; Julie A Zorn; Stanley B Prusiner; Fred Cohen; R Kiplin Guy
Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
Bioorganic & medicinal chemistry letters 2006;16(18):4913-6.
2006: Moriz Mayer; P Therese Lang; Sabina Gerber; Peter B Madrid; Irene Gómez Pinto; R Kiplin Guy; Tom L James
Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA.
Chemistry & biology 2006;13(9):993-1000.
2006: Marc O Anderson; Hong Yu; Cristina Penaranda; Betty A Maddux; Ira D Goldfine; Jack F Youngren; R Kiplin Guy
Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.
Journal of combinatorial chemistry 2006;8(5):784-90.
2006: Peter B Madrid; Ally P Liou; Joe L DeRisi; R Kiplin Guy
Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.
Journal of medicinal chemistry 2006;49(15):4535-43.
2006: Leggy Arnold; Eva Estébanez-Perpiñá; Marie Togashi; Anang A Shelat; Cory Ocasio; Andrea C McReynolds; Phuong Nguyen; John D Baxter; Robert J Fletterick; Paul Webb; R Kiplin Guy
A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.
Science's STKE : signal transduction knowledge environment 2006;2006(341):pl3.
2006: Jennifer L Weisman; Ally P Liou; Anang A Shelat; Fred Cohen; R Kiplin Guy; Joe L DeRisi
Searching for new antimalarial therapeutics amongst known drugs.
Chemical biology & drug design 2006;67(6):409-16.
2006: Felice Lu; Seung-Wook Chi; Do-Hyoung Kim; Kyou-Hoon Han; Irwin D Kuntz; R Kiplin Guy
Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors.
Journal of combinatorial chemistry 2006;8(3):315-25.
2006: Nicholas L Mills; Matthew D Daugherty; Alan D Frankel; R Kiplin Guy
An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction.
Journal of the American Chemical Society 2006;128(11):3496-7.
2006: Marc O Anderson; John Sherrill; Peter B Madrid; Ally P Liou; Jennifer L Weisman; Joe L DeRisi; R Kiplin Guy
Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum.
Bioorganic & medicinal chemistry 2006;14(2):334-43.
2005: Leggy Arnold; Eva Estébanez-Perpiñá; Marie Togashi; Natalia Jouravel; Anang A Shelat; Andrea C McReynolds; Ellena Mar; Phuong Nguyen; John D Baxter; Robert J Fletterick; Paul Webb; R Kiplin Guy
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.
The Journal of biological chemistry 2005;280(52):43048-55.
2005: Brian Y Feng; Anang A Shelat; Thompson N Doman; R Kiplin Guy; Brian Shoichet
High-throughput assays for promiscuous inhibitors.
Nature chemical biology 2005;1(3):146-8.
2005: Marc O Anderson; Anang A Shelat; R Kiplin Guy
A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin.
The Journal of organic chemistry 2005;70(12):4578-84.
2005: Jamie M R Moore; R Kiplin Guy
Coregulator interactions with the thyroid hormone receptor.
Molecular & cellular proteomics : MCP 2005;4(4):475-82.
2005: Eva Estébanez-Perpiñá; Jamie M R Moore; Ellena Mar; Edson Delgado-Rodrigues; Phuong Nguyen; John D Baxter; Benjamin M Buehrer; Paul Webb; Robert J Fletterick; R Kiplin Guy
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
The Journal of biological chemistry 2005;280(9):8060-8.
2005: Peter B Madrid; John Sherrill; Ally P Liou; Jennifer L Weisman; Joe L DeRisi; R Kiplin Guy
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.
Bioorganic & medicinal chemistry letters 2005;15(4):1015-8.
2005: Naoaki Fujii; Jeremy P Mallari; Elizabeth Hansell; Zachary B Mackey; Patricia Doyle; Y M Zhou; Jiri Gut; Philip J Rosenthal; James H McKerrow; R Kiplin Guy
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Bioorganic & medicinal chemistry letters 2005;15(1):121-3.
2004: Leggy Arnold; Wenchen Luo; R Kiplin Guy
Synthesis of medium ring heterocycles using an intramolecular Heck reaction.
Organic letters 2004;6(17):3005-7.
2004: Jamie M R Moore; Sarah J Galicia; Andrea C McReynolds; Ngoc-Ha Nguyen; Thomas S Scanlan; R Kiplin Guy
Quantitative proteomics of the thyroid hormone receptor-coregulator interactions.
The Journal of biological chemistry 2004;279(26):27584-90.
2004: Peter B Madrid; Nathan T Wilson; Joe L DeRisi; R Kiplin Guy
Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.
Journal of combinatorial chemistry 2004;6(3):437-42.
2004: William Evans; R Kiplin Guy
Gene expression as a drug discovery tool.
Nature genetics 2004;36(3):214-5.
2004: Timothy Geistlinger; Andrea C McReynolds; R Kiplin Guy
Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms.
Chemistry & biology 2004;11(2):273-81.
2004: Naoaki Fujii; Richard B Jacobsen; Nichole L Wood; Joseph S Schoeniger; R Kiplin Guy
A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D).
Bioorganic & medicinal chemistry letters 2004;14(2):427-9.
2003: Christopher J Collins; Birgit Schilling; Malin Young; Gavin Dollinger; R Kiplin Guy
Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides.
Bioorganic & medicinal chemistry letters 2003;13(22):4023-6.
2003: Naoaki Fujii; Jose J Haresco; Kathleen A P Novak; David Stokoe; Irwin D Kuntz; R Kiplin Guy
A selective irreversible inhibitor targeting a PDZ protein interaction domain.
Journal of the American Chemical Society 2003;125(40):12074-5.
2003: Hong Yang; Anang A Shelat; R Kiplin Guy; Vadiraj S Gopinath; Tonghui Ma; Kai Du; Gergely L Lukacs; Alessandro Taddei; Chiara Folli; Nicoletta Pedemonte; Luis J V Galietta; Alan S Verkman
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.
The Journal of biological chemistry 2003;278(37):35079-85.
2003: Mark F Springsteel; Luis J V Galietta; Tonghui Ma; Kolbot By; Gideon O Berger; Hong Yang; Christopher W Dicus; Wonken Choung; Chao Quan; Anang A Shelat; R Kiplin Guy; Alan S Verkman; Mark J Kurth; Michael H Nantz
Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.
Bioorganic & medicinal chemistry 2003;11(18):4113-20.
2003: Timothy Geistlinger; R Kiplin Guy
Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2.
Journal of the American Chemical Society 2003;125(23):6852-3.
2003: Baruch Z Harris; Francis W Lau; Naoaki Fujii; R Kiplin Guy; Wendell A Lim
Role of electrostatic interactions in PDZ domain ligand recognition.
Biochemistry 2003;42(10):2797-805.
2003: Timothy Geistlinger; R Kiplin Guy
Steroid receptor coactivator peptidomimetics.
Methods in enzymology 2003;364():223-46.
2002: Kathleen A P Novak; Naoaki Fujii; R Kiplin Guy
Investigation of the PDZ domain ligand binding site using chemically modified peptides.
Bioorganic & medicinal chemistry letters 2002;12(17):2471-4.
2001: Timothy Geistlinger; R Kiplin Guy
An inhibitor of the interaction of thyroid hormone receptor beta and glucocorticoid interacting protein 1.
Journal of the American Chemical Society 2001;123(7):1525-6.
2000: P S Herradura; K A Pendola; R Kiplin Guy
Copper-mediated cross-coupling of aryl boronic acids and alkyl thiols.
Organic letters 2000;2(14):2019-22.