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Manuel Guzmán

Research Profile

Chemicals & Drugs

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Eduardo Pérez-Gómez; Miguel Quintanilla; C Andradas; J M Flores; Manuel Guzmán; J M Paramio; Cristina Sánchez
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.
Javier Díaz-Alonso; Manuel Guzmán; Ismael Galve-Roperh
Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development.
Javier Díaz-Alonso; Tania Aguado; Patricia Garcez; François Guillemot; Manuel Guzmán; Clementine Hofmann; Hui-Chen Lu; Beat Lutz; Javier Palazuelos; Chia-Shan Wu; Ismael Galve-Roperh
The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis.

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All Publications

2013: Eduardo Pérez-Gómez; Miguel Quintanilla; C Andradas; J M Flores; Manuel Guzmán; J M Paramio; Cristina Sánchez
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.
Oncogene 2013;32(20):2534-42.
2012: Javier Díaz-Alonso; Manuel Guzmán; Ismael Galve-Roperh
Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1607):3229-41.
2012: Javier Díaz-Alonso; Tania Aguado; Patricia Garcez; François Guillemot; Manuel Guzmán; Clementine Hofmann; Hui-Chen Lu; Beat Lutz; Javier Palazuelos; Chia-Shan Wu; Ismael Galve-Roperh
The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(47):16651-65.
2012: María Caffarel; Manuel Guzmán; Eduardo Pérez-Gómez; Clara Andradas; Cristina Sánchez
Cannabinoids: a new hope for breast cancer therapy?
Cancer treatment reviews 2012;38(7):911-8.
2011: Mar Lorente; Bárbara Meléndez; Manuela Mollejo; Fátima Rodríguez-Fornés; María Salazar; Sofia Torres; Juan A Barcia; Yolanda Campos-Martín; Arkaitz Carracedo; Elena García-Taboada; Manuel Guzmán; Sonia Hernández-Tiedra; Guillermo Velasco
Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death.
Autophagy 2011;7(9):1071-3.
2011: Javier Fernández-Ruiz; María Gómez-Cañas; Carmen Guaza; Manuel Guzmán; Raphael Mechoulam; Miguel Moreno-Martet; Cristina Palomo-Garo; Carmen Rodríguez-Cueto; Julián Romero; Sara Valdeolivas; José A Ramos
Prospects for cannabinoid therapies in basal ganglia disorders.
British journal of pharmacology 2011;163(7):1365-78.
2011: D Vara; Guillermo Velasco; Manuel Guzmán; N Olea-Herrero; M Salazar; Inés Díaz-Laviada
Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.
Cell death and differentiation 2011;18(7):1099-111.
2011: C Andradas; María Caffarel; E Pérez-Gómez; M Salazar; M Lorente; G Velasco; Manuel Guzmán; Cristina Sánchez
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
Oncogene 2011;30(2):245-52.
2011: María Salazar; Sonia Hernández-Tiedra; Sofía Torres; Mar Lorente; Manuel Guzmán; Guillermo Velasco
Detecting autophagy in response to ER stress signals in cancer.
Methods in enzymology 2011;489():297-317.
2011: Sofía Torres; Mar Lorente; Fátima Rodríguez-Fornés; Sonia Hernández-Tiedra; María Salazar; Elena García-Taboada; Juan Barcia; Manuel Guzmán; Guillermo Velasco
A combined preclinical therapy of cannabinoids and temozolomide against glioma.
Molecular cancer therapeutics 2011;10(1):90-103.
2011: Cristina Blázquez; Anna Chiarlone; Onintza Sagredo; Tania Aguado; María Ruth Pazos; Eva Resel; Javier Palazuelos; Boris Julien; María Salazar; Christine Börner; Cristina Benito; Carolina Carrasco; María Diez-Zaera; Paola Paoletti; Miguel Díaz-Hernández; Carolina Ruiz; Michael Sendtner; José J Lucas; Justo G de Yébenes; Giovanni Marsicano; Krisztina Monory; Beat Lutz; Julián Romero; Jordi Alberch; Silvia Ginés; Jürgen Kraus; Javier Fernández-Ruiz; Ismael Galve-Roperh; Manuel Guzmán
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.
Brain : a journal of neurology 2011;134(Pt 1):119-36.
2010: Manuel Guzmán
A new age for MAGL.
Chemistry & biology 2010;17(1):4-6.
2010: María Caffarel; Clara Andradas; Emilia Mira; Eduardo Pérez-Gómez; Camilla Cerutti; Gema Moreno-Bueno; Juana M Flores; Isabel García-Real; José Palacios; Santos Mañes; Manuel Guzmán; Cristina Sánchez
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.
Molecular cancer 2010;9():196.
2010: Adriana Barana; Irene Amorós; Ricardo Caballero; Ricardo Gómez; Lourdes Osuna; M Pilar Lillo; Cristina Blázquez; Manuel Guzmán; Eva Delpón; Juan Tamargo
Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner.
Cardiovascular research 2010;85(1):56-67.
2009: Javier Palazuelos; Tania Aguado; María Ruth Pazos; Boris Julien; Carolina Carrasco; Eva Resel; Onintza Sagredo; Cristina Benito; Julián Romero; Iñigo Azcoitia; Javier Fernández-Ruiz; Manuel Guzmán; Ismael Galve-Roperh
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.
Brain : a journal of neurology 2009;132(Pt 11):3152-64.
2009: María Salazar; Arkaitz Carracedo; Iñigo J Salanueva; Sonia Hernández-Tiedra; Ainara Egia; Mar Lorente; Patricia Vázquez; Sofia Torres; Juan L Iovanna; Manuel Guzmán; Patricia Boya; Guillermo Velasco
TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action.
Autophagy 2009;5(7):1048-9.
2009: Ismael Galve-Roperh; Javier Palazuelos; Tania Aguado; Manuel Guzmán
The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders.
European archives of psychiatry and clinical neuroscience 2009;259(7):371-82.
2009: Mar Lorente; Arkaitz Carracedo; Sofía Torres; Francesco Natali; Ainara Egia; Sonia Hernández-Tiedra; María Salazar; Cristina Blázquez; Manuel Guzmán; Guillermo Velasco
Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
Glia 2009;57(13):1374-85.
2009: María Salazar; Arkaitz Carracedo; Iñigo J Salanueva; Sonia Hernández-Tiedra; Mar Lorente; Ainara Egia; Patricia Vázquez; Cristina Blázquez; Sofía Torres; Stephane García; Jonathan Nowak; Gian María Fimia; Mauro Piacentini; Francesco Cecconi; Pier Paolo Pandolfi; Luis González-Feria; Juan L Iovanna; Manuel Guzmán; Patricia Boya; Guillermo Velasco
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
The Journal of clinical investigation 2009;119(5):1359-72.
2008: Javier Palazuelos; Nathalie Davoust; Boris Julien; Eric Hatterer; Tania Aguado; Urij Rampampam; Cristina Benito; Julian Romero; Augusto Silva; Manuel Guzmán; Serge Nataf; Ismael Galve-Roperh
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.
The Journal of biological chemistry 2008;283(19):13320-9.
2008: Cristina Blázquez; María Salazar; Arkaitz Carracedo; Mar Lorente; Ainara Egia; Luis González-Feria; Amador Haro; Guillermo Velasco; Manuel Guzmán
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Cancer research 2008;68(6):1945-52.
2008: Ismael Galve-Roperh; Tania Aguado; Javier Palazuelos; Manuel Guzmán
Mechanisms of control of neuron survival by the endocannabinoid system.
Current pharmaceutical design 2008;14(23):2279-88.
2008: Cristina Blázquez; Arkaitz Carracedo; María Salazar; Mar Lorente; Ainara Egia; Luis González-Feria; Amador Haro; Guillermo Velasco; Manuel Guzmán
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
Neuropharmacology 2008;54(1):235-43.
2007: Tania Aguado; Eva Romero; Krisztina Monory; Javier Palazuelos; Michael Sendtner; Giovanni Marsicano; Beat Lutz; Manuel Guzmán; Ismael Galve-Roperh
The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.
The Journal of biological chemistry 2007;282(33):23892-8.
2007: Guillermo Velasco; Arkaitz Carracedo; Cristina Blázquez; Mar Lorente; Tania Aguado; Amador Haro; Cristina Sánchez; Ismael Galve-Roperh; Manuel Guzmán
Cannabinoids and gliomas.
Molecular neurobiology 2007;36(1):60-7.
2007: Javier Fernández-Ruiz; Manuel Guzmán; José A Ramos
Preface: cannabinoids as new tools for the treatment of neurological disorders.
Molecular neurobiology 2007;36(1):1-2.
2007: Ismael Galve-Roperh; Tania Aguado; Javier Palazuelos; Manuel Guzmán
The endocannabinoid system and neurogenesis in health and disease.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2007;13(2):109-14.
2007: Tania Aguado; Arkaitz Carracedo; Boris Julien; Guillermo Velasco; Garry Milman; Urij Rampampam; Luis Alvarez; Manuel Guzmán; Ismael Galve-Roperh
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.
The Journal of biological chemistry 2007;282(9):6854-62.
2007: Javier Fernández-Ruiz; Julián Romero; Guillermo Velasco; Rosa M Tolón; José A Ramos; Manuel Guzmán
Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
Trends in pharmacological sciences 2007;28(1):39-45.
2006: Cristina Blázquez; Arkaitz Carracedo; Lucía Barrado; Pedro José Real; José Luis Fernández-Luna; Guillermo Velasco; Marcos Malumbres; Manuel Guzmán
Cannabinoid receptors as novel targets for the treatment of melanoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2633-5.
2006: Javier Palazuelos; Tania Aguado; Ainara Egia; Urij Rampampam; Manuel Guzmán; Ismael Galve-Roperh
Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2405-7.
2006: Manuel Guzmán; M J Duarte; Cristina Blázquez; J Ravina; M C Rosa; Ismael Galve-Roperh; Cristina Sánchez; Guillermo Velasco; Luis González-Feria
A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
British journal of cancer 2006;95(2):197-203.
2006: Arkaitz Carracedo; Meritxell Gironella; Mar Lorente; Stephane Garcia; Manuel Guzmán; Guillermo Velasco; Juan L Iovanna
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.
Cancer research 2006;66(13):6748-55.
2006: María Caffarel; David Sarrió; José Palacios; Manuel Guzmán; Cristina Sánchez
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.
Cancer research 2006;66(13):6615-21.
2006: Blanca Herrera; Arkaitz Carracedo; María Diez-Zaera; Teresa Gómez del Pulgar; Manuel Guzmán; Guillermo Velasco
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.
Experimental cell research 2006;312(11):2121-31.
2006: Arkaitz Carracedo; Mar Lorente; Ainara Egia; Cristina Blázquez; Stephane García; Valentin Giroux; Cedric Malicet; Raquel Villuendas; Meritxell Gironella; Luis González-Feria; Miguel Angel Piris; Juan L Iovanna; Manuel Guzmán; Guillermo Velasco
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.
Cancer cell 2006;9(4):301-12.
2006: Arkaitz Carracedo; Ainara Egia; Manuel Guzmán; Guillermo Velasco
p8 Upregulation sensitizes astrocytes to oxidative stress.
FEBS letters 2006;580(6):1571-5.
2006: Tania Aguado; Javier Palazuelos; Krisztina Monory; Nephi Stella; Benjamin F Cravatt; Beat Lutz; Giovanni Marsicano; Zaal Kokaia; Manuel Guzmán; Ismael Galve-Roperh
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1551-61.
2006: Ismael Galve-Roperh; Tania Aguado; Daniel Rueda; Guillermo Velasco; Manuel Guzmán
Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development.
Current pharmaceutical design 2006;12(18):2319-25.
2005: Tania Aguado; Krisztina Monory; Javier Palazuelos; Nephi Stella; Benjamin F Cravatt; Beat Lutz; Giovanni Marsicano; Zaal Kokaia; Manuel Guzmán; Ismael Galve-Roperh
The endocannabinoid system drives neural progenitor proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1704-6.
2005: Blanca Herrera; Arkaitz Carracedo; María Diez-Zaera; Manuel Guzmán; Guillermo Velasco
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.
FEBS letters 2005;579(22):5084-8.
2005: Guillermo Velasco; Ismael Galve-Roperh; Cristina Sánchez; Cristina Blázquez; Amador Haro; Manuel Guzmán
Cannabinoids and ceramide: two lipids acting hand-by-hand.
Life sciences 2005;77(14):1723-31.
2005: Belén G Ramírez; Cristina Blázquez; Teresa Gómez del Pulgar; Manuel Guzmán; María L de Ceballos
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(8):1904-13.
2005: Manuel Guzmán
Effects on cell viability.
Handbook of experimental pharmacology 2005;(168):627-42.
2004: Guillermo Velasco; Ismael Galve-Roperh; Cristina Sánchez; Cristina Blázquez; Manuel Guzmán
Hypothesis: cannabinoid therapy for the treatment of gliomas?
Neuropharmacology 2004;47(3):315-23.
2004: Cristina Blázquez; Luis González-Feria; Luis Alvarez; Amador Haro; M Llanos Casanova; Manuel Guzmán
Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas.
Cancer research 2004;64(16):5617-23.
2004: Arkaitz Carracedo; Math J H Geelen; María Diez; Kentaro Hanada; Manuel Guzmán; Guillermo Velasco
Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids.
The Biochemical journal 2004;380(Pt 2):435-40.
2004: Manuel Guzmán; Cristina Blázquez
Ketone body synthesis in the brain: possible neuroprotective effects.
Prostaglandins, leukotrienes, and essential fatty acids 2004;70(3):287-92.
2003: Manuel Guzmán
Cannabinoids: potential anticancer agents.
Nature reviews. Cancer 2003;3(10):745-55.
2003: Cristina Blázquez; M Llanos Casanova; Anna Planas; Teresa Gómez Del Pulgar; Concepción Villanueva; M Jesús Fernández-Aceñero; Julián Aragonés; John W Huffman; José L Jorcano; Manuel Guzmán
Inhibition of tumor angiogenesis by cannabinoids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):529-31.
2003: M Llanos Casanova; Cristina Blázquez; Jesús Martínez-Palacio; Concepción Villanueva; M Jesús Fernández-Aceñero; John W Huffman; José L Jorcano; Manuel Guzmán
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
The Journal of clinical investigation 2003;111(1):43-50.
2002: Ismael Galve-Roperh; Daniel Rueda; Teresa Gómez del Pulgar; Guillermo Velasco; Manuel Guzmán
Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.
Molecular pharmacology 2002;62(6):1385-92.
2002: Teresa Gómez del Pulgar; María L de Ceballos; Manuel Guzmán; Guillermo Velasco
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
The Journal of biological chemistry 2002;277(39):36527-33.
2002: Manuel Guzmán; Cristina Sánchez; Ismael Galve-Roperh
Cannabinoids and cell fate.
Pharmacology & therapeutics 2002;95(2):175-84.
2002: Teresa Gómez del Pulgar; Guillermo Velasco; Cristina Sánchez; Amador Haro; Manuel Guzmán
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.
The Biochemical journal 2002;363(Pt 1):183-8.
2001: Cristina Sánchez; María L de Ceballos; T Gomez del Pulgar; Daniel Rueda; C Corbacho; Guillermo Velasco; Ismael Galve-Roperh; John W Huffman; S Ramón y Cajal; Manuel Guzmán
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
Cancer research 2001;61(15):5784-9.
2001: Cristina Sánchez; Daniel Rueda; Bruno Ségui; Ismael Galve-Roperh; Thierry Levade; Manuel Guzmán
The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.
Molecular pharmacology 2001;59(5):955-9.
2001: Cristina Blázquez; Math J H Geelen; Guillermo Velasco; Manuel Guzmán
The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes.
FEBS letters 2001;489(2-3):149-53.
2001: Manuel Guzmán; Cristina Sánchez; Ismael Galve-Roperh
Control of the cell survival/death decision by cannabinoids.
Journal of molecular medicine (Berlin, Germany) 2001;78(11):613-25.
2001: Manuel Guzmán; Ismael Galve-Roperh; Cristina Sánchez
Ceramide: a new second messenger of cannabinoid action.
Trends in pharmacological sciences 2001;22(1):19-22.
2000: Cristina Blázquez; Ismael Galve-Roperh; Manuel Guzmán
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(14):2315-22.
2000: Daniel Rueda; Ismael Galve-Roperh; Amador Haro; Manuel Guzmán
The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase.
Molecular pharmacology 2000;58(4):814-20.
2000: Teresa Gómez del Pulgar; Guillermo Velasco; Manuel Guzmán
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.
The Biochemical journal 2000;347(Pt 2):369-73.
2000: Ismael Galve-Roperh; Cristina Sánchez; M L Cortés; T Gómez del Pulgar; M Izquierdo; Manuel Guzmán
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
Nature medicine 2000;6(3):313-9.
2000: Manuel Guzmán; Guillermo Velasco; Math J H Geelen
Do cytoskeletal components control fatty acid translocation into liver mitochondria?
Trends in endocrinology and metabolism: TEM 2000;11(2):49-53.
1999: Dominique Melck; Daniel Rueda; Ismael Galve-Roperh; Luciano De Petrocellis; Manuel Guzmán; Vincenzo Di Marzo
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.
FEBS letters 1999;463(3):235-40.
1999: Cristina Blázquez; A Woods; María L de Ceballos; David Carling; Manuel Guzmán
The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes.
Journal of neurochemistry 1999;73(4):1674-82.
1999: Manuel Guzmán; W Klein; T Gómez del Pulgar; Math J H Geelen
Metabolism of trans fatty acids by hepatocytes.
Lipids 1999;34(4):381-6.
1999: Cristina Blázquez; Cristina Sánchez; Argimiro Daza; Ismael Galve-Roperh; Manuel Guzmán
The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme.
Journal of neurochemistry 1999;72(4):1759-68.
1999: Guillermo Velasco; Math J H Geelen; Teresa Gómez del Pulgar; Manuel Guzmán
Possible involvement of cytoskeletal components in the control of hepatic carnitine palmitoyltransferase I activity.
Advances in experimental medicine and biology 1999;466():43-52.
1999: Manuel Guzmán; Cristina Sánchez
Effects of cannabinoids on energy metabolism.
Life sciences 1999;65(6-7):657-64.
1998: Guillermo Velasco; P Passilly; Manuel Guzmán; Norbert Latruffe
Loss of response of carnitine palmitoyltransferase I to okadaic acid in transformed hepatic cells.
Biochemical pharmacology 1998;56(11):1485-8.
1998: Guillermo Velasco; Teresa Gómez del Pulgar; David Carling; Manuel Guzmán
Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components.
FEBS letters 1998;439(3):317-20.
1998: Cristina Sánchez; Ismael Galve-Roperh; Daniel Rueda; Manuel Guzmán
Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.
Molecular pharmacology 1998;54(5):834-43.
1998: Cristina Blázquez; Cristina Sánchez; Guillermo Velasco; Manuel Guzmán
Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes.
Journal of neurochemistry 1998;71(4):1597-606.
1998: Cristina Sánchez; Ismael Galve-Roperh; C Canova; Philippe Brachet; Manuel Guzmán
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
FEBS letters 1998;436(1):6-10.
1998: Guillermo Velasco; Math J H Geelen; T Gómez del Pulgar; Manuel Guzmán
Malonyl-CoA-independent acute control of hepatic carnitine palmitoyltransferase I activity. Role of Ca2+/calmodulin-dependent protein kinase II and cytoskeletal components.
The Journal of biological chemistry 1998;273(34):21497-504.
1997: Cristina Sánchez; Guillermo Velasco; Manuel Guzmán
Delta9-tetrahydrocannabinol stimulates glucose utilization in C6 glioma cells.
Brain research 1997;767(1):64-71.
1997: Guillermo Velasco; Math J H Geelen; Manuel Guzmán
Control of hepatic fatty acid oxidation by 5'-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism.
Archives of biochemistry and biophysics 1997;337(2):169-75.
1997: Cristina Sánchez; Guillermo Velasco; Manuel Guzmán
Metabolic stimulation of mouse spleen lymphocytes by low doses of delta9-tetrahydrocannabinol.
Life sciences 1997;60(19):1709-17.
1997: Guillermo Velasco; Manuel Guzmán; V A Zammit; Math J H Geelen
Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes.
The Biochemical journal 1997;321 ( Pt 1)():211-6.
1996: G Velasco; Cristina Sánchez; Math J H Geelen; Manuel Guzmán
Are cytoskeletal components involved in the control of hepatic carnitine palmitoyltransferase I activity?
Biochemical and biophysical research communications 1996;224(3):754-9.
1996: Manuel Guzmán; G Velasco; J Castro
Effects of extracellular ATP on hepatic fatty acid metabolism.
The American journal of physiology 1996;270(4 Pt 1):G701-7.
1995: Manuel Guzmán; C Bijleveld; Math J H Geelen
Flexibility of zonation of fatty acid oxidation in rat liver.
The Biochemical journal 1995;311 ( Pt 3)():853-60.
1995: Manuel Guzmán; Javier Fernández-Ruiz; Cristina Sánchez; G Velasco; José A Ramos
Effects of anandamide on hepatic fatty acid metabolism.
Biochemical pharmacology 1995;50(6):885-8.
1994: Manuel Guzmán; G Velasco; J Castro; Victor A Zammit
Inhibition of carnitine palmitoyltransferase I by hepatocyte swelling.
FEBS letters 1994;344(2-3):239-41.
1993: Manuel Guzmán; J P Cortés; J Castro
Effects of lovastatin on hepatic fatty acid metabolism.
Lipids 1993;28(12):1087-93.
1993: Manuel Guzmán; Math J H Geelen; Robert Harris
Effects of proglycosyn (LY177507) on fatty acid metabolism in rat hepatocytes.
Archives of biochemistry and biophysics 1993;305(1):141-6.
1993: Manuel Guzmán; Math J H Geelen
Regulation of fatty acid oxidation in mammalian liver.
Biochimica et biophysica acta 1993;1167(3):227-41.
1992: Manuel Guzmán; Math J H Geelen
Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid.
The Biochemical journal 1992;287 ( Pt 2)():487-92.
1992: Manuel Guzmán; I R Azzolin; C C Moulin; Marcos L S Perry
Pre- and postnatal protein undernutrition increases hepatic carnitine palmitoyltransferase I activity and decreases enzyme sensitivity to inhibitors in the suckling rat.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1992;24(10):471-3.
1991: Manuel Guzmán; J Castro
Okadaic acid stimulates carnitine palmitoyltransferase I activity and palmitate oxidation in isolated rat hepatocytes.
FEBS letters 1991;291(1):105-8.
1991: J Castro; J P Cortés; Manuel Guzmán
Properties of the mitochondrial membrane and carnitine palmitoyltransferase in the periportal and the perivenous zone of the liver. Effects of chronic ethanol feeding.
Biochemical pharmacology 1991;41(12):1987-95.
1991: Manuel Guzmán; Ana Saborido; J Castro; F Molano; A Megias
Treatment with anabolic steroids increases the activity of the mitochondrial outer carnitine palmitoyltransferase in rat liver and fast-twitch muscle.
Biochemical pharmacology 1991;41(5):833-5.
1990: Manuel Guzmán; J Castro
Simultaneous stimulation of fatty acid synthesis and oxidation in rat hepatocytes by vanadate.
Archives of biochemistry and biophysics 1990;283(1):90-5.
1990: Manuel Guzmán; J Castro
Alterations in the regulatory properties of hepatic fatty acid oxidation and carnitine palmitoyltransferase I activity after ethanol feeding and withdrawal.
Alcoholism, clinical and experimental research 1990;14(3):472-7.
1989: Manuel Guzmán; J Castro
Zonation of fatty acid metabolism in rat liver.
The Biochemical journal 1989;264(1):107-13.
1989: Manuel Guzmán; J Castro
Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations.
Biochimica et biophysica acta 1989;1002(3):405-8.
1988: Manuel Guzmán; J Castro
Effects of endurance exercise on carnitine palmitoyltransferase I from rat heart, skeletal muscle and liver mitochondria.
Biochimica et biophysica acta 1988;963(3):562-5.
1988: Manuel Guzmán; Math J H Geelen
Effects of ethanol feeding on the activity and regulation of hepatic carnitine palmitoyltransferase I.
Archives of biochemistry and biophysics 1988;267(2):580-8.
1988: Manuel Guzmán; Math J H Geelen
Short-term inhibition of carnitine palmitoyltransferase I activity in rat hepatocytes incubated with ethanol.
Biochemical and biophysical research communications 1988;154(2):682-7.
1988: Manuel Guzmán; Math J H Geelen
Short-term regulation of carnitine palmitoyltransferase activity in isolated rat hepatocytes.
Biochemical and biophysical research communications 1988;151(2):781-7.
1988: A Maquedano; Manuel Guzmán; J Castro
Dependence with nutritional status of the ethanol effects on fatty acid metabolism in rat hepatocytes.
The International journal of biochemistry 1988;20(9):937-41.
1987: Manuel Guzmán; J Castro; A Maquedano
Ethanol feeding to rats reversibly decreases hepatic carnitine palmitoyltransferase activity and increases enzyme sensitivity to malonyl-CoA.
Biochemical and biophysical research communications 1987;149(2):443-8.
1987: J Castro; A Maquedano; Manuel Guzmán
Stimulation by ethanol of triglyceride synthesis in fasted rat hepatocytes is dependent on the increase of glycerol 3-phosphate levels.
Biochemistry international 1987;14(3):475-82.
1987: J Castro; A Maquedano; Manuel Guzmán
Short and long term effects of ethanol on glycerolipid synthesis from palmitate in fasted rat hepatocytes.
The International journal of biochemistry 1987;19(7):595-9.