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Steven Gygi

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TOP 3
Jin-Mi Heo; Jason R Nielson; Noah Dephoure; Steven P Gygi; Jared Rutter
Intramolecular interactions control Vms1 translocation to damaged mitochondria.
Shireen A Sarraf; Mathew E Sowa; Virginia Guarani-Pereira; Steven P Gygi; Edward L Huttlin; Malavika Raman; J Wade Harper
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Michael P Weekes; Robin Antrobus; Steven P Gygi; Christina Montag; Emma Poole; John H Sinclair; Duncan L Smith; Suzanne Talbot; Shireen Y L Tan; Paul J Lehner
Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection.

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All Publications

2013: Jin-Mi Heo; Jason R Nielson; Noah Dephoure; Steven P Gygi; Jared Rutter
Intramolecular interactions control Vms1 translocation to damaged mitochondria.
Molecular biology of the cell 2013;24(9):1263-73.
2013: Shireen A Sarraf; Mathew E Sowa; Virginia Guarani-Pereira; Steven P Gygi; Edward L Huttlin; Malavika Raman; J Wade Harper
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Nature 2013;496(7445):372-6.
2013: Michael P Weekes; Robin Antrobus; Steven P Gygi; Christina Montag; Emma Poole; John H Sinclair; Duncan L Smith; Suzanne Talbot; Shireen Y L Tan; Paul J Lehner
Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection.
Science (New York, N.Y.) 2013;340(6129):199-202.
2013: Xiaocui Zhang; Joseph Tcherkezian; Sebastien Carreno; Loic Fort; Jacob A Galan; Haihua Gu; Steven P Gygi; Edward L Huttlin; Genevieve Lavoie; Philippe Roux
Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.
Molecular and cellular biology 2013;33(8):1657-70.
2013: Sean M Armour; Eric J Bennett; Craig R Braun; Steven P Gygi; J Wade Harper; Steven B McMahon; Xiao-Yong Zhang; David A Sinclair
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology 2013;33(8):1487-502.
2013: Noah Dephoure; Kathleen L Gould; Steven P Gygi; Douglas R Kellogg
Mapping and analysis of phosphorylation sites: a quick guide for cell biologists.
Molecular biology of the cell 2013;24(5):535-42.
2013: Karla J Oldknow; Peter J O'Shaughnessy; Andrew A Pitsillides; Alan L Schneyer; Jan Seebacher; Judit Villen; Tapasree Goswami; Steven P Gygi; Abir Mukherjee
Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor β (TGFβ) signaling is essential for testicular aging and regulating testis size.
Endocrinology 2013;154(3):1310-20.
2013: Ingvild Aukrust; Lise Bjørkhaug; Torgeir Flatmark; Steven P Gygi; Wilhelm Haas; Bente B Johansson; Rohit N Kulkarni; Janne Molnes; Yvonne Müller; Maria Negahdar; Oddmund Søvik; Pål R Njølstad
SUMOylation of pancreatic glucokinase regulates its cellular stability and activity.
The Journal of biological chemistry 2013;288(8):5951-62.
2013: James A Nathan; Lily Ting; Hyoung Tae Kim; Steven P Gygi; Alfred L Goldberg
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?
The EMBO journal 2013;32(4):552-65.
2013: Helge Raeder; Mette Vesterhus; Abdelfattah El Ouaamari; Steven P Gygi; Jiang Hu; C Ronald Kahn; Dan Kawamori; Chong Wee Liew; Fiona E McAllister; Anders Molven; Pål R Njølstad; Joao A Paulo; Rohit N Kulkarni
Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young).
PloS one 2013;8(4):e60229.
2013: Mandana Arbab; Joel M Chick; Hyunjii Cho; David K Gifford; Steven P Gygi; Richard L Maas; Shaun Mahony; Viveca W S Morris; P Alexander Rolfe; John Peter van Hoff; Richard I Sherwood
A multi-parametric flow cytometric assay to analyze DNA-protein interactions.
Nucleic acids research 2013;41(2):e38.
2013: Chikwendu Ibebunjo; Tracee Kendall; Christine Li; QiCheng Ma; Judit Markovits; Jun Shi; Elizabeth Skuba; Michelle Steinkrauss; Chad Vickers; Zhidan Wu; Yunyu Zhang; Sophie Brachat; Michelle Broome; Joel M Chick; Brian A Clarke; Joseph Cruz; John K Eash; Brigitte Fournier; Jean-Rene Galarneau; Sabine Gutzwiller; Steven P Gygi; David J Glass
Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia.
Molecular and cellular biology 2013;33(2):194-212.
2012: John E Dominy; Jessica Feldman; Steven P Gygi; Mark P Jedrychowski; Michael J Jurczak; Yoonjin Lee; Raul Mostoslavsky; Kerry Pierce; Joao Paulo Camporez; Helen Chim; Clary B Clish; John M Denu; Hai-Bin Ruan; Gerald I Shulman; Xiaoyong Yang; Pere Puigserver
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Molecular cell 2012;48(6):900-13.
2012: David P Nusinow; Daniel J O'Connell; Yingzi Yue; Joel M Chick; Steven P Gygi; Adam Kiezun; Richard L Maas; Shamil Sunyaev
Network-based inference from complex proteomic mixtures using SNIPE.
Bioinformatics (Oxford, England) 2012;28(23):3115-22.
2012: Martin Wühr; Wilhelm Haas; Marc W Kirschner; Graeme C McAlister; Leonid Peshkin; Ramin Rad; Steven P Gygi
Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.
Analytical chemistry 2012;84(21):9214-21.
2012: Maja M Janas; Mike Aguiar; Mark A Behlke; Etienne Gagnon; Steven P Gygi; Abigail S Harris; Jonathan M Shaffer; Yerramilli V B K Subrahmanyam; Bingbing Wang; Kai W Wucherpfennig; Carl D Novina
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.
RNA (New York, N.Y.) 2012;18(11):2041-55.
2012: Marie Cargnello; Jonas F Dorn; Steven P Gygi; Edward L Huttlin; Paul S Maddox; Joseph Tcherkezian; Philippe Roux
Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.
Molecular and cellular biology 2012;32(22):4572-84.
2012: Kristin E Burns; Francisca Cerda-Maira; Steven P Gygi; Stevan R Hubbard; Fiona E McAllister; Francesco Melandri; Julian Mintseris; Elke E Noens; Huib Ovaa; Carsten Schwerdtfeger; Matthias Wilmanns; K Heran Darwin
Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase.
The Journal of biological chemistry 2012;287(44):37522-9.
2012: Guillaume Thibault; Markus R Wenk; Guanghou Shui; Steven P Gygi; Nurzian Ismail; Woong Kim; Graeme C McAlister; Davis T W Ng
The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network.
Molecular cell 2012;48(1):16-27.
2012: Graeme C McAlister; Ian Pike; John C Rogers; Lily Ting; Wilhelm Haas; Edward L Huttlin; Mark P Jedrychowski; Karsten Kuhn; Justin D Blethrow; Robert A Grothe; Steven P Gygi
Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.
Analytical chemistry 2012;84(17):7469-78.
2012: Wei-Chung Chiang; Mark Eckersdorff; Steven P Gygi; David Lombard; Travis Mazer; Daniel X Tishkoff; Joshua Wilson-Grady; Bo Yang; Xiaokun Yu; Ao-Lin Hsu
C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
PLoS genetics 2012;8(9):e1002948.
2012: Shenhav Cohen; Steven P Gygi; Bo Zhai; Alfred L Goldberg
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy.
The Journal of cell biology 2012;198(4):575-89.
2012: Ryan C Kunz; Fiona E McAllister; John Rush; Steven P Gygi
A high-throughput, multiplexed kinase assay using a benchtop orbitrap mass spectrometer to investigate the effect of kinase inhibitors on kinase signaling pathways.
Analytical chemistry 2012;84(14):6233-9.
2012: Hiroyuki Inuzuka; Alan W Lau; Keiko Nakayama; Pier Paolo Pandolfi; Shavali Shaik; Julie Teruya-Feldstein; Alex Toker; Lixin Wan; Zhiwei Wang; Y Rebecca Chin; Lydia W S Finley; Hidefumi Fukushima; Daming Gao; Steven P Gygi; Marcia Haigis; Wen Yang; Bo Zhai; Wenyi Wei
Acetylation-dependent regulation of Skp2 function.
Cell 2012;150(1):179-93.
2012: Daniel K Bricker; Michèle Brivet; Caleb M Cardon; Yu-Chan Chen; James E Cox; Noah Dephoure; Steven P Gygi; Thomas Orsak; Claire Redin; John C Schell; Eric B Taylor; Carl S Thummel; Jonathan G Van Vranken; Sihem Boudina; Audrey Boutron; Jared Rutter
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Science (New York, N.Y.) 2012;337(6090):96-100.
2012: Daniel R Calnan; Alexsandra Espejo; Tapasree Goswami; Or Gozani; Steven P Gygi; Xiaobing Shi; Timothy R Stowe; Ashley E Webb; Jamie L White; Mark T Bedford; Anne Brunet
Methylation by Set9 modulates FoxO3 stability and transcriptional activity.
Aging 2012;4(7):462-79.
2012: Shuzhen Chen; Steven P Gygi; Xiaodong Li; Xiaole Shirley Liu; Ruitu Lv; Honghui Ma; Jian Ma; Judit Villen; Feizhen Wu; Li-Jun Xiong; Wenqi Xu; Yang Shi
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Genes & development 2012;26(12):1364-75.
2012: Hidefumi Fukushima; Daming Gao; Steven P Gygi; Hiroyuki Inuzuka; Eijiro Jimi; Alan W Lau; Akinobu Matsumoto; Keiko Nakayama; Keiichi I Nakayama; Shavali Shaik; Lixin Wan; Min Yuan; Bo Zhai; John M Asara; Wenyi Wei
SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Cell reports 2012;1(5):434-43.
2012: Sharon M Blättler; Helen Chim; John T Cunningham; Steven P Gygi; Wilhelm Haas; Huifei Liu; Klaas Romanino; Markus A Rüegg; Yang Shi; Francisco Verdeguer; Pere Puigserver
Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.
Cell metabolism 2012;15(4):505-17.
2012: Noah Dephoure; Steven P Gygi
Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to rapamycin in yeast.
Science signaling 2012;5(217):rs2.
2012: Yu-Chan Chen; Nicolas C Denko; Noah Dephoure; Steven P Gygi; Jin-Mi Heo; Nandita Nath; Ioanna Papandreou; Eric B Taylor; Aline Tonhato; Jared Rutter
Identification of a protein mediating respiratory supercomplex stability.
Cell metabolism 2012;15(3):348-60.
2012: Nevena V Dimova; Daniel Finley; Steven P Gygi; Nathaniel A Hathaway; Donald S Kirkpatrick; Byung-Hoon Lee; Marie Lea Berkowitz; Randall W King
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
Nature cell biology 2012;14(2):168-76.
2012: Pontus Boström; Jang Hyun Choi; Saverio Cinti; Steven P Gygi; Kurt Højlund; Mark P Jedrychowski; Shingo Kajimura; Anisha Korde; James C Lo; Jonathan Z Long; Kyle A Rasbach; Hua Tu; Birgitte F Vind; Jun Wu; Li Ye; Maria Cristina Zingaretti; Elisabeth Almer Boström; Bruce M Spiegelman
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Nature 2012;481(7382):463-8.
2011: Kimberly Anderson; Xianlong Gao; Steven P Gygi; Kristin C Hicks; Kyle A Nordquist; Bo Zhai; Tarun B Patel
Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins.
The Journal of biological chemistry 2011;286(49):42027-36.
2011: Mark P Jedrychowski; Ramin Rad; Mathew E Sowa; Wilhelm Haas; Edward L Huttlin; Steven P Gygi
Evaluation of HCD- and CID-type fragmentation within their respective detection platforms for murine phosphoproteomics.
Molecular & cellular proteomics : MCP 2011;10(12):M111.009910.
2011: Geng Tian; Steven P Gygi; Christopher P Hill; Bettina Huck; Min Jae Lee; Fiona McAllister; Soyeon Park; Daniel Finley
An asymmetric interface between the regulatory and core particles of the proteasome.
Nature structural & molecular biology 2011;18(11):1259-67.
2011: Weiguo Zou; Roland Baron; Nicholas Brady; Roger J Davis; Matthew B Greenblatt; Steven P Gygi; Dorothy Zhang Hu; Dallas Jones; Shashi Kant; Sutada Lotinun; Jae-Hyuck Shim; Bo Zhai; Laurie H Glimcher
MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.
The Journal of clinical investigation 2011;121(11):4383-92.
2011: Lily Ting; Ramin Rad; Steven P Gygi; Wilhelm Haas
MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics.
Nature methods 2011;8(11):937-40.
2011: K G Guruharsha; Steven P Gygi; Bhaveen Kapadia; Emily McKillip; Julian Mintseris; Bob Obar; Bayan Parsa; David Y Rhee; Jean-François Rual; Saumini Shah; Mark Stapleton; Namita Vaidya; Pujita Vaidya; KV VijayRaghavan; Kenneth H Wan; Christina Wong; Charles Yu; Bo Zhai; Chapman Beekman; Joseph W Carlson; Susan E Celniker; Odise Cenaj; Xiao Chen; Spyros Artavanis-Tsakonas
A protein complex network of Drosophila melanogaster.
Cell 2011;147(3):690-703.
2011: Daming Gao; Steven P Gygi; J Wade Harper; Hiroyuki Inuzuka; Pengda Liu; Jason W Locasale; Costas A Lyssiotis; Shavali Shaik; Meng-Kwang Marcus Tan; Alex Toker; Lixin Wan; John M Asara; Lewis C Cantley; Y Rebecca Chin; Hidefumi Fukushima; Bo Zhai; Wenyi Wei
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Molecular cell 2011;44(2):290-303.
2011: Woong Kim; Jing Li; Anthony Possemato; Ramin Rad; John Rush; Mathew E Sowa; Eric J Bennett; Michael J Comb; Ailan Guo; J Wade Harper; Edward L Huttlin; Steven P Gygi
Systematic and quantitative assessment of the ubiquitin-modified proteome.
Molecular cell 2011;44(2):325-40.
2011: Soyeon Park; Geng Tian; Steven P Gygi; Woong Kim; Daniel Finley
Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response.
The Journal of biological chemistry 2011;286(42):36652-66.
2011: Stacy L Harvey; Noah Dephoure; Germán Enciso; Jeremy Gunawardena; Steven P Gygi; Doug R Kellogg
A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast.
Molecular biology of the cell 2011;22(19):3595-608.
2011: Pavel Ivanov; Judit Villen; Mohamed M Emara; Steven P Gygi; Paul Anderson
Angiogenin-induced tRNA fragments inhibit translation initiation.
Molecular cell 2011;43(4):613-23.
2011: Caroline H Yi; Bo Zhai; John M Asara; Lewis C Cantley; George Q Daley; Steven P Gygi; Gregory J Heffron; Sven G Hyberts; Il-Ho Jang; Fupeng Li; Chuan-Fa Liu; Jason W Locasale; Harry Luithardt; Heling Pan; Ricard Rodriguez-Mias; Jan Seebacher; Hadar Sharfi; Matthew G Vander Heiden; Gerhard Wagner; Renliang Yang; Junying Yuan
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
Cell 2011;146(4):607-20.
2011: Kelly N Nobles; Sudarshan Rajagopal; Sudha K Shenoy; arun shukla; Ryan T Strachan; Kunhong Xiao; Seungkirl Ahn; Erin A Bressler; Steven P Gygi; Makoto R Hara; Teng-Yi Huang; Christopher M Lam; Robert J Lefkowitz
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
Science signaling 2011;4(185):ra51.
2011: Peter C W Lee; Mathew E Sowa; Steven P Gygi; J Wade Harper
Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.
Molecular cell 2011;43(3):392-405.
2011: Francisca A Cerda-Maira; Nadine J Bode; Kristin E Burns; Steven P Gygi; Fiona McAllister; K Heran Darwin
Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
EMBO reports 2011;12(8):863-70.
2011: Sidharth V Puram; Joshua T Wilson-Grady; Steven P Gygi; Yoshiho Ikeuchi; Albert H Kim; Andreas Merdes; Azad Bonni
A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain.
Nature neuroscience 2011;14(8):973-83.
2011: Ronghu Wu; Bo Zhai; Noah Dephoure; Wilhelm Haas; Edward L Huttlin; Mathew E Sowa; Steven P Gygi
A large-scale method to measure absolute protein phosphorylation stoichiometries.
Nature methods 2011;8(8):677-83.
2011: Ronghu Wu; Bo Zhai; Noah Dephoure; Wilhelm Haas; Edward L Huttlin; Mathew E Sowa; Steven P Gygi
Correct interpretation of comprehensive phosphorylation dynamics requires normalization by protein expression changes.
Molecular & cellular proteomics : MCP 2011;10(8):M111.009654.
2011: Noah Dephoure; Steven P Gygi
A solid phase extraction-based platform for rapid phosphoproteomic analysis.
Methods (San Diego, Calif.) 2011;54(4):379-86.
2011: Dominique Helmlinger; Samuel Marguerat; Danielle L Swaney; Judit Villén; Jürg Bähler; Steven P Gygi; Fred Winston
Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
The EMBO journal 2011;30(14):2843-52.
2011: Yonghao Yu; Lewis C Cantley; Steven P Gygi; Gregory R Hoffman; Neil Kubica; Xiaoju Max Ma; George Poulogiannis; Judit Villén; Qian Yang; Sang-Oh Yoon; John Blenis
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Science (New York, N.Y.) 2011;332(6035):1322-6.
2011: Peter Mulligan; Luisa Di Stefano; Nicholas J Dyson; Grace Gill; Steven P Gygi; Jun-Yuan Ji; Madhura Kulkarni; Raul Mostoslavsky; S Hani Najafi-Shoushtari; Joy L Nishikawa; Jian Ouyang; Debra Toiber; Qun Wang; Fajun Yang; Anders M Näär
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
Molecular cell 2011;42(5):689-99.
2011: Siwanon Jirawatnotai; Thomas A Kunkel; David M Livingston; Wojciech Michowski; John Quackenbush; Tanja van Harn; Yaoyu E Wang; Bing Xia; Agnieszka Zagozdzon; Lisa Becks; Frederic Bienvenu; Alan B Clark; Mick Correll; Joshua E Elias; Tapasree Goswami; Steven P Gygi; Yiduo Hu; Piotr Sicinski
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.
Nature 2011;474(7350):230-4.
2011: Nadia Litterman; Yoshiho Ikeuchi; Gilbert Gallardo; Brenda C O'Connell; Mathew E Sowa; Steven P Gygi; J Wade Harper; Azad Bonni
An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
PLoS biology 2011;9(5):e1001060.
2011: Inbal Ziv; Yulia Matiuhin; Donald S Kirkpatrick; Zoi Erpapazoglou; Sebastien Leon; Marina Pantazopoulou; Woong Kim; Steven P Gygi; Rosine Haguenauer-Tsapis; Noa Reis; Michael H Glickman; Oded Kleifeld
A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.
Molecular & cellular proteomics : MCP 2011;10(5):M111.009753.
2011: Tingting Sun; Nicola Aceto; Kristen L Meerbrey; Jessica D Kessler; Chunshui Zhou; Ilenia Migliaccio; Don X Nguyen; Natalya N Pavlova; Maria Botero; Jian Huang; Ronald J Bernardi; Earlene Schmitt; Guang Hu; Mamie Z Li; Noah Dephoure; Steven P Gygi; Mitchell Rao; Chad J Creighton; Susan G Hilsenbeck; Chad A Shaw; Donna Muzny; Richard A Gibbs; David A Wheeler; C Kent Osborne; Rachel Schiff; Mohamed Bentires-Alj; Stephen J Elledge; Thomas F Westbrook
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Cell 2011;144(5):703-18.
2011: Hiroyuki Inuzuka; Shavali Shaik; Ichiro Onoyama; Daming Gao; Alan Tseng; richard s maser; Bo Zhai; Lixin Wan; Alejandro Gutierrez; Alan W Lau; Yonghong Xiao; Amanda L Christie; Jon Aster; Jeffrey Settleman; Steven P Gygi; Andrew L Kung; Thomas Look; Keiichi I Nakayama; Ronald A DePinho; Wenyi Wei
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Nature 2011;471(7336):104-9.
2011: Andrew C Tolonen; Wilhelm Haas; Amanda C Chilaka; John Aach; Steven P Gygi; George M Church
Proteome-wide systems analysis of a cellulosic biofuel-producing microbe.
Molecular systems biology 2011;7():461.
2011: Danielle A Sliter; Mike Aguiar; Steven P Gygi; Richard J H Wojcikiewicz
Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation.
The Journal of biological chemistry 2011;286(2):1074-82.
2011: Lydia W S Finley; Steven P Gygi; Wilhelm Haas; Vincent Procaccio; Douglas C Wallace; Valérie Desquiret-Dumas; Marcia Haigis
Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.
PloS one 2011;6(8):e23295.
2011: Jayachandran Gopalakrishnan; Steven P Gygi; Timothy L Megraw; Vito Mennella; Daniela Nicastro; Andrew H Smith; Bo Zhai; David A Agard; Stephanie Blachon; Tomer Avidor-Reiss
Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome.
Nature communications 2011;2():359.
2011: Ting-Lei Gu; Julie Nardone; Yi Wang; Marc Loriaux; Judit Villén; Sean Beausoleil; Meghan Tucker; Jon Kornhauser; Jianmin Ren; Joan MacNeill; Steven P Gygi; Brian J Druker; Michael C Heinrich; John Rush; Roberto D Polakiewicz
Survey of activated FLT3 signaling in leukemia.
PloS one 2011;6(4):e19169.
2010: Edward L Huttlin; Mark P Jedrychowski; Josh Elias; Tapasree Goswami; Ramin Rad; Sean A Beausoleil; Judit Villén; Wilhelm Haas; Mathew E Sowa; Steven P Gygi
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell 2010;143(7):1174-89.
2010: Craig R Braun; Julian Mintseris; Evripidis Gavathiotis; Gregory H Bird; Steven P Gygi; Loren D Walensky
Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
Chemistry & biology 2010;17(12):1325-33.
2010: Bryan F Shaw; Gerhard Wagner; Haribabu Arthanari; Basar Bilgicer; Armando Durazo; Dominique Frueh; Steven P Gygi; Andrew Lee; Max Narovlyansky; Michael P Pollastri; George M Whitesides
Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.
Journal of the American Chemical Society 2010;132(49):17411-25.
2010: Xue-Ming Xu; Anton A Turanov; Bradley A Carlson; Min-Hyuk Yoo; Robert A Everley; Renu Nandakumar; Irina Sorokina; Steven P Gygi; Vadim N Gladyshev; Dolph L Hatfield
Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21430-4.
2010: Eric J Bennett; John Rush; Steven P Gygi; J Wade Harper
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Cell 2010;143(6):951-65.
2010: Brenda C O'Connell; Britt Adamson; John R Lydeard; Mathew E Sowa; Alberto Ciccia; Andrea L Bredemeyer; Michael Schlabach; Steven P Gygi; Stephen J Elledge; J Wade Harper
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
Molecular cell 2010;40(4):645-57.
2010: Hyunju Ryu; Maiko Furuta; Donald Kirkpatrick; Steven P Gygi; Yoshiaki Azuma
PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.
The Journal of cell biology 2010;191(4):783-94.
2010: Neus Teixidó-Travesa; Judit Villén; Cristina Lacasa; Maria Teresa Bertran; Marco Archinti; Steven P Gygi; Carme Caelles; Joan Roig; Jens Lüders
The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8.
Molecular biology of the cell 2010;21(22):3963-72.
2010: Jin-Mi Heo; Nurit Livnat-Levanon; Eric B Taylor; Kevin T Jones; Noah Dephoure; Julia Ring; Jianxin Xie; Jeffrey L Brodsky; Frank Madeo; Steven P Gygi; Kaveh Ashrafi; Michael H Glickman; Jared Rutter
A stress-responsive system for mitochondrial protein degradation.
Molecular cell 2010;40(3):465-80.
2010: Danny M Chou; Britt Adamson; Noah E Dephoure; Xu Tan; Amanda C Nottke; Kristen E Hurov; Steven P Gygi; Monica P Colaiácovo; Stephen J Elledge
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18475-80.
2010: Eduardo M Torres; Noah Dephoure; Amudha Panneerselvam; Cheryl M Tucker; Charles A Whittaker; Steven P Gygi; Maitreya J Dunham; Angelika Amon
Identification of aneuploidy-tolerating mutations.
Cell 2010;143(1):71-83.
2010: Francisco Dieguez-Acuña; Shohta Kodama; Yoshiaki Okubo; Ana Cristina Paz; Steven P Gygi; Denise L Faustman
Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen.
The international journal of biochemistry & cell biology 2010;42(10):1651-60.
2010: Kobina Dufu; Michaela J Livingstone; Jan Seebacher; Steven P Gygi; Stuart A Wilson; Robin Reed
ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.
Genes & development 2010;24(18):2043-53.
2010: Daming Gao; Lixin Wan; Hiroyuki Inuzuka; Anders H Berg; Alan Tseng; Bo Zhai; Shavali Shaik; Eric Bennett; Adriana E Tron; Jessica A Gasser; Alan Lau; Steven P Gygi; J Wade Harper; James A DeCaprio; Alex Toker; Wenyi Wei
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Molecular cell 2010;39(5):797-808.
2010: Byung-Hoon Lee; Min Jae Lee; Soyeon Park; Dong-Chan Oh; Suzanne Elsasser; Ping-Chung Chen; Carlos Gartner; Nevena Dimova; John Hanna; Steven P Gygi; Scott M Wilson; Randall W King; Daniel Finley
Enhancement of proteasome activity by a small-molecule inhibitor of USP14.
Nature 2010;467(7312):179-84.
2010: Kunhong Xiao; Jinpeng Sun; Jihee Kim; Sudarshan Rajagopal; Bo Zhai; Judit Villén; Wilhelm Haas; Jeffrey J Kovacs; arun shukla; Makoto R Hara; Marylens Hernandez; Alexander Lachmann; Shan Zhao; Yuan Lin; Yishan Cheng; Kensaku Mizuno; Avi Ma'ayan; Steven P Gygi; Robert J Lefkowitz
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15299-304.
2010: Ho-Sup Lee; Yulia Komarova; Elena S Nadezhdina; Rana Anjum; John G Peloquin; Joseph M Schober; Oana Danciu; Jeffrey van Haren; Niels Galjart; Steven P Gygi; Anna Akhmanova; Gary G Borisy
Phosphorylation controls autoinhibition of cytoplasmic linker protein-170.
Molecular biology of the cell 2010;21(15):2661-73.
2010: Felipe R Teixeira; Sami Yokoo; Carlos A Gartner; Adriana O Manfiolli; Munira M A Baqui; Eliana M Assmann; Ana Leticia G C Maragno; Huijun Yu; Primal De Lanerolle; Jörg Kobarg; Steven P Gygi; Marcelo D Gomes
Identification of FBXO25-interacting proteins using an integrated proteomics approach.
Proteomics 2010;10(15):2746-57.
2010: Rachel H Roberts-Galbraith; Melanie D Ohi; Bryan A Ballif; Jun-Song Chen; Ian McLeod; W Hayes McDonald; Steven P Gygi; John R Yates; Kathleen L Gould
Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
Molecular cell 2010;39(1):86-99.
2010: Christian Behrends; Mathew E Sowa; Steven P Gygi; J Wade Harper
Network organization of the human autophagy system.
Nature 2010;466(7302):68-76.
2010: Hua Jin; Susan Roehl White; Toshinobu Shida; Stefan Schulz; Mike Aguiar; Steven P Gygi; J. Fernando Bazan; Maxence V Nachury
The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.
Cell 2010;141(7):1208-19.
2010: Marta Isasa; Elijah J Katz; Woong Kim; Verónica Yugo; Sheyla González; Donald S Kirkpatrick; Timothy M Thomson; Daniel Finley; Steven P Gygi; Bernat Crosas
Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome.
Molecular cell 2010;38(5):733-45.
2010: Mike Aguiar; Wilhelm Haas; Sean A Beausoleil; John Rush; Steven P Gygi
Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets.
Journal of proteome research 2010;9(6):3103-7.
2010: Hyunju Ryu; Gada Al-Ani; Katelyn Deckert; Donald Kirkpatrick; Steven P Gygi; Mary Dasso; Yoshiaki Azuma
PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes.
The Journal of biological chemistry 2010;285(19):14415-23.
2010: younghoon kee; Kailin Yang; Martin A Cohn; Wilhelm Haas; Steven P Gygi; Alan D D'Andrea
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.
The Journal of biological chemistry 2010;285(15):11252-7.
2010: Frédéric Bienvenu; Siwanon Jirawatnotai; Josh Elias; Clifford A Meyer; Karolina Mizeracka; Alexander Marson; Garrett M Frampton; Megan F Cole; Duncan T Odom; Junko Odajima; Yan Geng; Agnieszka Zagozdzon; Marie Jecrois; Richard A Young; X Shirley Liu; Constance L Cepko; Steven P Gygi; Piotr Sicinski
Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.
Nature 2010;463(7279):374-8.
2010: Melodie L Knowlton; Laura M Selfors; Carolyn N Wrobel; Ting-Lei Gu; Bryan A Ballif; Steven P Gygi; Roberto Polakiewicz; Joan S Brugge
Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.
PloS one 2010;5(10):e13587.
2010: Albrecht Moritz; Yu Li; Ailan Guo; Judit Villén; Yi Wang; Joan MacNeill; Jon Kornhauser; Kam Sprott; Jing Zhou; Anthony Possemato; Jian Min Ren; Peter Hornbeck; Lewis C Cantley; Steven P Gygi; John Rush; Michael J Comb
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.
Science signaling 2010;3(136):ra64.
2010: Richard A Festa; Fiona McAllister; Michael J Pearce; Julian Mintseris; Kristin E Burns; Steven P Gygi; K Heran Darwin
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
PloS one 2010;5(1):e8589.
2010: Josh Elias; Steven P Gygi
Target-decoy search strategy for mass spectrometry-based proteomics.
Methods in molecular biology (Clifton, N.J.) 2010;604():55-71.
2010: Mark P Jedrychowski; Carlos A Gartner; Steven P Gygi; Li Zhou; Joachim Herz; Konstantin V Kandror; Paul F Pilch
Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling.
The Journal of biological chemistry 2010;285(1):104-14.
2009: Hengyao Niu; Lihong Wan; Valeria Busygina; YoungHo Kwon; Jasmina A Allen; Xue Li; Ryan C Kunz; Kazuishi Kubota; Beatrice Wang; Patrick Sung; Kevan M Shokat; Steven P Gygi; Nancy M Hollingsworth
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.
Molecular cell 2009;36(3):393-404.
2009: Rachel Kaminsky; Carilee Denison; Ulrike Bening-Abu-Shach; Andrew D Chisholm; Steven P Gygi; Limor Broday
SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans.
Developmental cell 2009;17(5):724-35.
2009: Kazuishi Kubota; Rana Anjum; Yonghao Yu; Ryan C Kunz; Jannik N Andersen; Manfred Kraus; Heike Keilhack; Kumiko Nagashima; Stefan Krauss; Cloud Paweletz; Ronald C Hendrickson; Adam S Feldman; Chin-Lee Wu; John Rush; Judit Villén; Steven P Gygi
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification.
Nature biotechnology 2009;27(10):933-40.
2009: Huai-Xiang Hao; Oleh Khalimonchuk; Margit Schraders; Noah Dephoure; Jean-Pierre Bayley; Henricus Kunst; Peter Devilee; Cor W R J Cremers; Joshua Schiffman; Brandon G Bentz; Steven P Gygi; Dennis R Winge; Hannie Kremer; Jared Rutter
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Science (New York, N.Y.) 2009;325(5944):1139-42.
2009: Timothy J Kelly; Carles Lerin; Wilhelm Haas; Steven P Gygi; Pere Puigserver
GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.
The Journal of biological chemistry 2009;284(30):19945-52.
2009: Mathew E Sowa; Eric J Bennett; Steven P Gygi; J Wade Harper
Defining the human deubiquitinating enzyme interaction landscape.
Cell 2009;138(2):389-403.
2009: Yonghao Yu; Rana Anjum; Kazuishi Kubota; John Rush; Judit Villen; Steven P Gygi
A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(28):11606-11.
2009: Jennifer M Svendsen; Agata Smogorzewska; Mathew E Sowa; Brenda C. O'Connell; Steven P Gygi; Stephen J Elledge; J Wade Harper
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Cell 2009;138(1):63-77.
2009: Hyoung Tae Kim; kwang pyo kim; Tomoaki Uchiki; Steven P Gygi; Alfred L Goldberg
S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.
The EMBO journal 2009;28(13):1867-77.
2009: Shenhav Cohen; Jeffrey J Brault; Steven P Gygi; David J Glass; David M Valenzuela; Carlos Gartner; Esther Latres; Alfred L Goldberg
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.
The Journal of cell biology 2009;185(6):1083-95.
2009: Soyeon Park; Jeroen Roelofs; Woong Kim; Jessica Robert; Marion Schmidt; Steven P Gygi; Daniel Finley
Hexameric assembly of the proteasomal ATPases is templated through their C termini.
Nature 2009;459(7248):866-70.
2009: Jeroen Roelofs; Soyeon Park; Wilhelm Haas; Geng Tian; Fiona E McAllister; Ying Huo; Byung-Hoon Lee; Fan Zhang; Yigong Shi; Steven P Gygi; Daniel Finley
Chaperone-mediated pathway of proteasome regulatory particle assembly.
Nature 2009;459(7248):861-5.
2009: Yuki Abe; Sang-Oh Yoon; Kazuishi Kubota; Michelle C Mendoza; Steven P Gygi; John Blenis
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.
The Journal of biological chemistry 2009;284(22):14939-48.
2009: Zengqiang Yuan; Maria K Lehtinen; Paola Merlo; Judit Villén; Steven P Gygi; Azad Bonni
Regulation of neuronal cell death by MST1-FOXO1 signaling.
The Journal of biological chemistry 2009;284(17):11285-92.
2009: Jessica A Hurt; Bob Obar; Bo Zhai; Natalie G Farny; Steven P Gygi; Pamela A Silver
A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export.
The Journal of cell biology 2009;185(2):265-77.
2009: Henrike C Besche; Wilhelm Haas; Steven P Gygi; Alfred L Goldberg
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.
Biochemistry 2009;48(11):2538-49.
2009: Martin A Cohn; younghoon kee; Wilhelm Haas; Steven P Gygi; Alan D D'Andrea
UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
The Journal of biological chemistry 2009;284(8):5343-51.
2009: Matthew L Hemming; Josh Elias; Steven P Gygi; Dennis J Selkoe
Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
PloS one 2009;4(12):e8477.
2008: Mohammad R Motamedi; Eun-Jin Erica Hong; Xue Li; Scott Gerber; Carilee Denison; Steven P Gygi; Danesh Moazed
HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
Molecular cell 2008;32(6):778-90.
2008: Karim Mekhail; Jan Seebacher; Steven P Gygi; Danesh Moazed
Role for perinuclear chromosome tethering in maintenance of genome stability.
Nature 2008;456(7222):667-70.
2008: Lai Xu; Mathew E Sowa; Jing Chen; Xue Li; Steven P Gygi; J Wade Harper
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.
Molecular biology of the cell 2008;19(12):5059-71.
2008: Dominique Helmlinger; Samuel Marguerat; Judit Villén; Steven P Gygi; Jürg Bähler; fred winston
The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Genes & development 2008;22(22):3184-95.
2008: Michael J Pearce; Julian Mintseris; Jessica Ferreyra; Steven P Gygi; K Heran Darwin
Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.
Science (New York, N.Y.) 2008;322(5904):1104-7.
2008: Yulia Matiuhin; Donald Kirkpatrick; Inbal Ziv; Woong Kim; Arun Dakshinamurthy; Oded Kleifeld; Steven P Gygi; Noa Reis; Michael H Glickman
Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome.
Molecular cell 2008;32(3):415-25.
2008: Judit Villén; Sean A Beausoleil; Steven P Gygi
Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis.
Proteomics 2008;8(21):4444-52.
2008: Corey E Bakalarski; Josh Elias; Judit Villén; Wilhelm Haas; Scott A Gerber; Patrick A Everley; Steven P Gygi
The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses.
Journal of proteome research 2008;7(11):4756-65.
2008: Johannes R Buchberger; Megumi Onishi; Geng Li; Jan Seebacher; Adam D Rudner; Steven P Gygi; Danesh Moazed
Sir3-nucleosome interactions in spreading of silent chromatin in Saccharomyces cerevisiae.
Molecular and cellular biology 2008;28(22):6903-18.
2008: Matthew L Hemming; Josh Elias; Steven P Gygi; Dennis J Selkoe
Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.
PLoS biology 2008;6(10):e257.
2008: Daehyun Baek; Judit Villén; Chanseok Shin; Fernando D Camargo; Steven P Gygi; David P Bartel
The impact of microRNAs on protein output.
Nature 2008;455(7209):64-71.
2008: Noah Dephoure; Chunshui Zhou; Judit Villén; Sean A Beausoleil; Corey E Bakalarski; Stephen J Elledge; Steven P Gygi
A quantitative atlas of mitotic phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10762-7.
2008: Brendon J Monahan; Judit Villén; Samuel Marguerat; Jürg Bähler; Steven P Gygi; fred winston
Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.
Nature structural & molecular biology 2008;15(8):873-80.
2008: Elçin Unal; Jill M Heidinger-Pauli; Woong Kim; Vincent Guacci; Itay Onn; Steven P Gygi; Douglas Koshland
A molecular determinant for the establishment of sister chromatid cohesion.
Science (New York, N.Y.) 2008;321(5888):566-9.
2008: Jean-François Ménétret; Ramanujan S Hegde; Mike Aguiar; Steven P Gygi; Eunyong Park; Tom A Rapoport; Christopher W Akey
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.
Structure (London, England : 1993) 2008;16(7):1126-37.
2008: Marisa J Wainszelbaum; Audra J Charron; Chen Kong; Donald Kirkpatrick; Priya Srikanth; M Alejandro Barbieri; Steven P Gygi; Philip D Stahl
The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.
The Journal of biological chemistry 2008;283(19):13233-42.
2008: Bo Zhai; Judit Villén; Sean A Beausoleil; Julian Mintseris; Steven P Gygi
Phosphoproteome analysis of Drosophila melanogaster embryos.
Journal of proteome research 2008;7(4):1675-82.
2008: Philipp Selenko; Dominique Frueh; Simon J Elsaesser; Wilhelm Haas; Steven P Gygi; Gerhard Wagner
In situ observation of protein phosphorylation by high-resolution NMR spectroscopy.
Nature structural & molecular biology 2008;15(3):321-9.
2008: Joshua T Wilson-Grady; Judit Villén; Steven P Gygi
Phosphoproteome analysis of fission yeast.
Journal of proteome research 2008;7(3):1088-97.
2008: Sang-Oh Yoon; Sejeong Shin; Yuzhen Liu; Bryan A Ballif; Michele S Woo; Steven P Gygi; John Blenis
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport.
Molecular cell 2008;29(3):362-75.
2008: Jeanne Tan; Esther S P Wong; Donald Kirkpatrick; Olga Pletnikova; Han Seok Ko; Shiam-Peng Tay; Michelle W L Ho; Juan C Troncoso; Steven P Gygi; Michael K Lee; Valina Dawson; Ted M Dawson; Kah Leong Lim
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Human molecular genetics 2008;17(3):431-9.
2008: Ailan Guo; Judit Villén; Jon Kornhauser; Kimberly A Lee; Matthew P Stokes; Klarisa Rikova; Anthony Possemato; Julie Nardone; Gregory Innocenti; Randall Wetzel; Yi Wang; Joan MacNeill; Jeffrey Mitchell; Steven P Gygi; John Rush; Roberto D Polakiewicz; Michael J Comb
Signaling networks assembled by oncogenic EGFR and c-Met.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):692-7.
2008: Judit Villén; Steven P Gygi
The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry.
Nature protocols 2008;3(10):1630-8.
2008: Jessica L Dermody; Jonathan M Dreyfuss; Judit Villén; Babatunde Ogundipe; Steven P Gygi; Peter J Park; Alfred S Ponticelli; Claire L Moore; Stephen Buratowski; Miriam E Bucheli
Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.
PloS one 2008;3(9):e3273.
2008: Thea A Egelhofer; Judit Villén; Derek McCusker; Steven P Gygi; Doug R Kellogg
The septins function in G1 pathways that influence the pattern of cell growth in budding yeast.
PloS one 2008;3(4):e2022.
2008: Bryan A Ballif; G Richard Carey; Shamil Sunyaev; Steven P Gygi
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Journal of proteome research 2008;7(1):311-8.
2007: Jean-François Ménétret; Julia Schaletzky; William M Clemons; Andrew R Osborne; Sigrid S Skånland; Carilee Denison; Steven P Gygi; Donald Kirkpatrick; Eunyong Park; Steven J Ludtke; Tom A Rapoport; Christopher W Akey
Ribosome binding of a single copy of the SecY complex: implications for protein translocation.
Molecular cell 2007;28(6):1083-92.
2007: Klarisa Rikova; Ailan Guo; Qingfu Zeng; Anthony Possemato; Jian Yu; Herbert Haack; Julie Nardone; Kimberly Lee; Cynthia Reeves; Yu Li; Yerong Hu; Zhiping Tan; Matthew Stokes; Laura Sullivan; Jeffrey Mitchell; Randy Wetzel; Joan MacNeill; Jian Min Ren; Jin Yuan; Corey E Bakalarski; Judit Villen; Jon M Kornhauser; Bradley Smith; Daiqiang Li; Xinmin Zhou; Steven P Gygi; Ting-Lei Gu; Roberto D Polakiewicz; John Rush; Michael J Comb
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Cell 2007;131(6):1190-203.
2007: Martin A Cohn; Przemyslaw Kowal; Kailin Yang; Wilhelm Haas; Tony T Huang; Steven P Gygi; Alan D D'Andrea
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.
Molecular cell 2007;28(5):786-97.
2007: Matthew P Stokes; John Rush; Joan MacNeill; Jian Min Ren; Kam Sprott; Julie Nardone; Vicky Yang; Sean A Beausoleil; Steven P Gygi; Mark Livingstone; HUI ZHANG; Roberto D Polakiewicz; Michael J Comb
Profiling of UV-induced ATM/ATR signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19855-60.
2007: Corey E Bakalarski; Wilhelm Haas; Noah E Dephoure; Steven P Gygi
The effects of mass accuracy, data acquisition speed, and search algorithm choice on peptide identification rates in phosphoproteomics.
Analytical and bioanalytical chemistry 2007;389(5):1409-19.
2007: Eric L Greer; Philip R Oskoui; Max R Banko; Jay M Maniar; Melanie P Gygi; Steven P Gygi; Anne Brunet
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.
The Journal of biological chemistry 2007;282(41):30107-19.
2007: Eric L Greer; Dara Dowlatshahi; Max R Banko; Judit Villen; Kimmi Hoang; Daniel Blanchard; Steven P Gygi; Anne Brunet
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Current biology : CB 2007;17(19):1646-56.
2007: Eiji Morita; Virginie Sandrin; Hyo-Young Chung; Scott G Morham; Steven P Gygi; Christopher K Rodesch; Wesley I Sundquist
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
The EMBO journal 2007;26(19):4215-27.
2007: Patrick A Everley; Carlos A Gartner; Wilhelm Haas; Alan Saghatelian; Josh Elias; Benjamin F Cravatt; Bruce R Zetter; Steven P Gygi
Assessing enzyme activities using stable isotope labeling and mass spectrometry.
Molecular & cellular proteomics : MCP 2007;6(10):1771-7.
2007: Paul F Pilch; Ricardo P Souto; Libin Liu; Mark P Jedrychowski; Eric A Berg; Catherine E Costello; Steven P Gygi
Cellular spelunking: exploring adipocyte caveolae.
Journal of lipid research 2007;48(10):2103-11.
2007: Mauro D Zappaterra; Steven N Lisgo; Susan Lindsay; Steven P Gygi; Christopher Walsh; Bryan A Ballif
A comparative proteomic analysis of human and rat embryonic cerebrospinal fluid.
Journal of proteome research 2007;6(9):3537-48.
2007: Hengyao Niu; Xue Li; Emily Job; Caroline Park; Danesh Moazed; Steven P Gygi; Nancy M Hollingsworth
Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis.
Molecular and cellular biology 2007;27(15):5456-67.
2007: Eiji Morita; Virginie Sandrin; Steven L Alam; Debra M Eckert; Steven P Gygi; Wesley I Sundquist
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.
Cell host & microbe 2007;2(1):41-53.
2007: Michael P Kowalski; Anne Dubouix-Bourandy; Milan Bajmoczi; David E Golan; Tanweer Zaidi; Yamara S Coutinho-Sledge; Melanie P Gygi; Steven P Gygi; Erik A C Wiemer; Gerald B Pier
Host resistance to lung infection mediated by major vault protein in epithelial cells.
Science (New York, N.Y.) 2007;317(5834):130-2.
2007: Jianping Jin; Xue Li; Steven P Gygi; J Wade Harper
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
Nature 2007;447(7148):1135-8.
2007: Rita Das; Jiong Yu; Zuo Zhang; Melanie P Gygi; Adrian R Krainer; Steven P Gygi; Robin Reed
SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.
Molecular cell 2007;26(6):867-81.
2007: Hyoung Tae Kim; kwang pyo kim; Fernando Lledias; Alexei F Kisselev; kenneth Scaglione; Dorota Skowyra; Steven P Gygi; Alfred L Goldberg
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.
The Journal of biological chemistry 2007;282(24):17375-86.
2007: Walter Luiz Siqueira; Weimin Zhang; Eva J Helmerhorst; Steven P Gygi; Frank G Oppenheim
Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS.
Journal of proteome research 2007;6(6):2152-60.
2007: Bin Wang; Shuhei Matsuoka; Bryan A Ballif; Dong Zhang; Agata Smogorzewska; Steven P Gygi; Stephen J Elledge
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Science (New York, N.Y.) 2007;316(5828):1194-8.
2007: Shuhei Matsuoka; Bryan A Ballif; Agata Smogorzewska; E Robert McDonald; Kristen E Hurov; Ji Luo; Corey E Bakalarski; Zhenming Zhao; Nicole Solimini; Yaniv lerenthal; Yosef Shiloh; Steven P Gygi; Stephen J Elledge
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science (New York, N.Y.) 2007;316(5828):1160-6.
2007: Frank Stegmeier; Mathew E Sowa; Grzegorz Nalepa; Steven P Gygi; J Wade Harper; Stephen J Elledge
The tumor suppressor CYLD regulates entry into mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8869-74.
2007: Marc Bühler; Wilhelm Haas; Steven P Gygi; Danesh Moazed
RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.
Cell 2007;129(4):707-21.
2007: Derek McCusker; Carilee Denison; Scott Anderson; Thea A Egelhofer; John R Yates; Steven P Gygi; Doug R Kellogg
Cdk1 coordinates cell-surface growth with the cell cycle.
Nature cell biology 2007;9(5):506-15.
2007: Agata Smogorzewska; Shuhei Matsuoka; Patrizia Vinciguerra; E Robert McDonald; Kristen E Hurov; Ji Luo; Bryan A Ballif; Steven P Gygi; Kay Hofmann; Alan D D'Andrea; Stephen J Elledge
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Cell 2007;129(2):289-301.
2007: Fei Lan; Mikel Zaratiegui; Judit Villén; Matthew W Vaughn; André Verdel; Maite Huarte; Yujiang Shi; Steven P Gygi; Danesh Moazed; Robert A Martienssen; Yang Shi
S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription.
Molecular cell 2007;26(1):89-101.
2007: Carlos A Gartner; Josh Elias; Corey E Bakalarski; Steven P Gygi
Catch-and-release reagents for broadscale quantitative proteomics analyses.
Journal of proteome research 2007;6(4):1482-91.
2007: Yu May Ma; Emmanuel Boucrot; Judit Villén; El Bachir Affar; Steven P Gygi; Heinrich G Göttlinger; Tomas Kirchhausen
Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.
The Journal of biological chemistry 2007;282(13):9805-12.
2007: Xue Li; Scott A Gerber; Adam D Rudner; Sean A Beausoleil; Wilhelm Haas; Judit Villén; Josh Elias; Steven P Gygi
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
Journal of proteome research 2007;6(3):1190-7.
2007: Josh Elias; Steven P Gygi
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.
Nature methods 2007;4(3):207-14.
2007: Shane M Buker; Tetsushi Iida; Marc Bühler; Judit Villén; Steven P Gygi; Jun-Ichi Nakayama; Danesh Moazed
Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast.
Nature structural & molecular biology 2007;14(3):200-7.
2007: Atul K Johri; Immaculada Margarit; Mark Broenstrup; Cecilia Brettoni; Lei Hua; Steven P Gygi; John L Telford; Guido Grandi; Lawrence C Paoletti
Transcriptional and proteomic profiles of group B Streptococcus type V reveal potential adherence proteins associated with high-level invasion.
Infection and immunity 2007;75(3):1473-83.
2007: Judit Villén; Sean A Beausoleil; Scott A Gerber; Steven P Gygi
Large-scale phosphorylation analysis of mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1488-93.
2007: Maurits F Kleijnen; Donald Kirkpatrick; Steven P Gygi
The ubiquitin-proteasome system regulates membrane fusion of yeast vacuoles.
The EMBO journal 2007;26(2):275-87.
2007: Scott A Gerber; Arminja N Kettenbach; John Rush; Steven P Gygi
The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.
Methods in molecular biology (Clifton, N.J.) 2007;359():71-86.
2006: Bernat Crosas; John Hanna; Donald Kirkpatrick; Dan Phoebe Zhang; Yoshiko Tone; Nathaniel A Hathaway; Christa Buecker; David S Leggett; Marion Schmidt; Randall W King; Steven P Gygi; Daniel Finley
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.
Cell 2006;127(7):1401-13.
2006: Julie Huang; Ilana L Brito; Judit Villén; Steven P Gygi; Angelika Amon; Danesh Moazed
Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer.
Genes & development 2006;20(20):2887-901.
2006: John Hanna; Nathaniel A Hathaway; Yoshiko Tone; Bernat Crosas; Suzanne Elsasser; Donald Kirkpatrick; David S Leggett; Steven P Gygi; Randall W King; Daniel Finley
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.
Cell 2006;127(1):99-111.
2006: Sean A Beausoleil; Judit Villén; Scott A Gerber; John Rush; Steven P Gygi
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nature biotechnology 2006;24(10):1285-92.
2006: Libin Liu; Mark P Jedrychowski; Steven P Gygi; Paul F Pilch
Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes.
Molecular biology of the cell 2006;17(10):4249-56.
2006: Bryan A Ballif; Zhongwei Cao; Daniel Schwartz; Kermit L Carraway; Steven P Gygi
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Journal of proteome research 2006;5(9):2372-9.
2006: Donald Kirkpatrick; Nathaniel A Hathaway; John Hanna; Suzanne Elsasser; John Rush; Daniel Finley; Randall W King; Steven P Gygi
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.
Nature cell biology 2006;8(7):700-10.
2006: Wilhelm Haas; Brendan K Faherty; Scott A Gerber; Josh Elias; Sean A Beausoleil; Corey E Bakalarski; Xue Li; Judit Villén; Steven P Gygi
Optimization and use of peptide mass measurement accuracy in shotgun proteomics.
Molecular & cellular proteomics : MCP 2006;5(7):1326-37.
2006: Maria Lehtinen; Zengqiang Yuan; Peter R Boag; Yue Yang; Judit Villén; Esther B E Becker; Sara DiBacco; Núria de la Iglesia; Steven P Gygi; T Keith Blackwell; Azad Bonni
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
Cell 2006;125(5):987-1001.
2006: Patrick A Everley; Corey E Bakalarski; Josh Elias; Carol G Waghorne; Sean A Beausoleil; Scott A Gerber; Brendan K Faherty; Bruce R Zetter; Steven P Gygi
Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation.
Journal of proteome research 2006;5(5):1224-31.
2006: Saskia B Neher; Judit Villén; Elizabeth C Oakes; Corey E Bakalarski; Robert T Sauer; Steven P Gygi; Tania A Baker
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon.
Molecular cell 2006;22(2):193-204.
2006: Tony T Huang; Sebastian M B Nijman; Kanchan D Mirchandani; Paul J Galardy; Martin A Cohn; Wilhelm Haas; Steven P Gygi; Hidde L Ploegh; René Bernards; Alan D D'Andrea
Regulation of monoubiquitinated PCNA by DUB autocleavage.
Nature cell biology 2006;8(4):339-47.
2006: Orion D Weiner; Maike C Rentel; Alex Ott; Glenn E Brown; Mark Jedrychowski; Michael B Yaffe; Steven P Gygi; Lewis C Cantley; Henry R Bourne; Marc W Kirschner
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
PLoS biology 2006;4(2):e38.
2006: Danesh Moazed; Marc Bühler; Shane M Buker; Serafin U Colmenares; E L Gerace; Scott A Gerber; Eun-Jin Erica Hong; Mohammad R Motamedi; André Verdel; Judit Villén; Steven P Gygi
Studies on the mechanism of RNAi-dependent heterochromatin assembly.
Cold Spring Harbor symposia on quantitative biology 2006;71():461-71.
2005: Dawn L MacLellan; Hanno Steen; Rosalyn M Adam; Monica Garlick; David Zurakowski; Steven P Gygi; Michael R Freeman; Keith R Solomon
A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells.
Proteomics 2005;5(18):4733-42.
2005: Eric M Mortensen; Wilhelm Haas; Melanie Gygi; Steven P Gygi; Doug R Kellogg
Cdc28-dependent regulation of the Cdc5/Polo kinase.
Current biology : CB 2005;15(22):2033-7.
2005: Marina K Holz; Bryan A Ballif; Steven P Gygi; John Blenis
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.
Cell 2005;123(4):569-80.
2005: Daniel Schwartz; Steven P Gygi
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets.
Nature biotechnology 2005;23(11):1391-8.
2005: Jian Li; Bryan A Ballif; Aimee M Powelka; Jun Dai; Steven P Gygi; Victor W Hsu
Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration.
Developmental cell 2005;9(5):663-73.
2005: Rana Anjum; Philippe Roux; Bryan A Ballif; Steven P Gygi; John Blenis
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.
Current biology : CB 2005;15(19):1762-7.
2005: Francisco J Dieguez-Acuna; Scott A Gerber; Shohta Kodama; Josh Elias; Sean A Beausoleil; Denise L Faustman; Steven P Gygi
Characterization of mouse spleen cells by subtractive proteomics.
Molecular & cellular proteomics : MCP 2005;4(10):1459-70.
2005: Josh Elias; Wilhelm Haas; Brendan K Faherty; Steven P Gygi
Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations.
Nature methods 2005;2(9):667-75.
2005: Stacy L Harvey; Alyson Charlet; Wilhelm Haas; Steven P Gygi; Doug R Kellogg
Cdk1-dependent regulation of the mitotic inhibitor Wee1.
Cell 2005;122(3):407-20.
2005: Donald Kirkpatrick; Carilee Denison; Steven P Gygi
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics.
Nature cell biology 2005;7(8):750-7.
2005: Chen Zhao; Carilee Denison; Jon M Huibregtse; Steven P Gygi; Robert M Krug
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10200-5.
2005: Eun-Jin Erica Hong; Judit Villén; Erica L Gerace; Steven P Gygi; Danesh Moazed
A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.
RNA biology 2005;2(3):106-11.
2005: Jin Xu; Nan Zhong; Haoyong Wang; Josh Elias; Christina Y Kim; Irina Woldman; Christian Pifl; Steven P Gygi; Changiz Geula; Bruce A Yankner
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.
Human molecular genetics 2005;14(9):1231-41.
2005: Marion Schmidt; Wilhelm Haas; Bernat Crosas; Patricia G Santamaria; Steven P Gygi; Thomas Walz; Daniel Finley
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.
Nature structural & molecular biology 2005;12(4):294-303.
2005: Joseph T Rodgers; Carles Lerin; Wilhelm Haas; Steven P Gygi; Bruce M Spiegelman; Pere Puigserver
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Nature 2005;434(7029):113-8.
2005: Donald Kirkpatrick; Scott A Gerber; Steven P Gygi
The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications.
Methods (San Diego, Calif.) 2005;35(3):265-73.
2005: Carilee Denison; Adam D Rudner; Scott A Gerber; Corey E Bakalarski; Danesh Moazed; Steven P Gygi
A proteomic strategy for gaining insights into protein sumoylation in yeast.
Molecular & cellular proteomics : MCP 2005;4(3):246-54.
2005: Carlos A Gartner; Bo Wen; Jiandi Wan; Ralph Becker; Guilford Jones; Steven P Gygi; Sidney D Nelson
Photochromic agents as tools for protein structure study: lapachenole is a photoaffinity ligand of cytochrome P450 3A4.
Biochemistry 2005;44(6):1846-55.
2005: Carilee Denison; Donald Kirkpatrick; Steven P Gygi
Proteomic insights into ubiquitin and ubiquitin-like proteins.
Current opinion in chemical biology 2005;9(1):69-75.
2005: Bryan A Ballif; Philippe Roux; Scott A Gerber; Jeffrey P MacKeigan; John Blenis; Steven P Gygi
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):667-72.
2004: Mohammad R Motamedi; André Verdel; Serafin U Colmenares; Scott A Gerber; Steven P Gygi; Danesh Moazed
Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.
Cell 2004;119(6):789-802.
2004: Roy Auty; Hanno Steen; Lawrence C Myers; Jim Persinger; Blaine Bartholomew; Steven P Gygi; Stephen Buratowski
Purification of active TFIID from Saccharomyces cerevisiae. Extensive promoter contacts and co-activator function.
The Journal of biological chemistry 2004;279(48):49973-81.
2004: Jean G Sathish; Jenna Walters; Jin Cai Luo; Kenneth G Johnson; Frances G Leroy; Paul Brennan; kwang pyo kim; Steven P Gygi; Benjamin G Neel; Ruth J Matthews
CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.
The Journal of biological chemistry 2004;279(46):47783-91.
2004: Bryan A Ballif; Judit Villén; Sean A Beausoleil; Daniel Schwartz; Steven P Gygi
Phosphoproteomic analysis of the developing mouse brain.
Molecular & cellular proteomics : MCP 2004;3(11):1093-101.
2004: Tatsuro S Takahashi; Pannyun Yiu; Michael F Chou; Steven P Gygi; Johannes C Walter
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex.
Nature cell biology 2004;6(10):991-6.
2004: Lea M Starita; Yuka Machida; Satish Sankaran; Josh Elias; Karen Griffin; Brian P Schlegel; Steven P Gygi; Jeffrey D Parvin
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.
Molecular and cellular biology 2004;24(19):8457-66.
2004: Philippe Roux; Bryan A Ballif; Rana Anjum; Steven P Gygi; John Blenis
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13489-94.
2004: Celeste J Richardson; Mark Bröenstrup; Diane C Fingar; Kristina Jülich; Bryan A Ballif; Steven P Gygi; John Blenis
SKAR is a specific target of S6 kinase 1 in cell growth control.
Current biology : CB 2004;14(17):1540-9.
2004: Sean A Beausoleil; Mark Jedrychowski; Daniel Schwartz; Josh Elias; Judit Villén; Jiaxu Li; Martin A Cohn; Lewis C Cantley; Steven P Gygi
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12130-5.
2004: Jason Tanny; Donald Kirkpatrick; Scott A Gerber; Steven P Gygi; Danesh Moazed
Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions.
Molecular and cellular biology 2004;24(16):6931-46.
2004: Hsin-Yi Henry Ho; Rajat Rohatgi; Andres M Lebensohn; Jiaxu Li; Steven P Gygi; Marc W Kirschner
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.
Cell 2004;118(2):203-16.
2004: Patrick A Everley; Jeroen Krijgsveld; Bruce R Zetter; Steven P Gygi
Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research.
Molecular & cellular proteomics : MCP 2004;3(7):729-35.
2004: Frank Gibbons; Josh Elias; Steven P Gygi; Frederick P Roth
SILVER helps assign peptides to tandem mass spectra using intensity-based scoring.
Journal of the American Society for Mass Spectrometry 2004;15(6):910-2.
2004: Junmin Peng; Myung Jong Kim; Dongmei Cheng; Duc M Duong; Steven P Gygi; Morgan Sheng
Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry.
The Journal of biological chemistry 2004;279(20):21003-11.
2004: Alexis Gautreau; Hsin-Yi Henry Ho; Jiaxu Li; Hanno Steen; Steven P Gygi; Marc W Kirschner
Purification and architecture of the ubiquitous Wave complex.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4379-83.
2004: Anne Brunet; Lora B Sweeney; J Fitzhugh Sturgill; Katrin F Chua; Paul L Greer; Yingxi Lin; Hien Tran; Sarah E Ross; Raul Mostoslavsky; Haim Y Cohen; Linda S Hu; Hwei-Ling Cheng; Mark P Jedrychowski; Steven P Gygi; David A Sinclair; Frederick W Alt; Michael E Greenberg
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Science (New York, N.Y.) 2004;303(5666):2011-5.
2004: Hideki Shimura; Daniel Schwartz; Steven P Gygi; Kenneth S Kosik
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
The Journal of biological chemistry 2004;279(6):4869-76.
2004: Josh Elias; Frank Gibbons; Oliver D King; Frederick P Roth; Steven P Gygi
Intensity-based protein identification by machine learning from a library of tandem mass spectra.
Nature biotechnology 2004;22(2):214-9.
2004: André Verdel; Songtao Jia; Scott Gerber; Tomoyasu Sugiyama; Steven P Gygi; Shiv I S Grewal; Danesh Moazed
RNAi-mediated targeting of heterochromatin by the RITS complex.
Science (New York, N.Y.) 2004;303(5658):672-6.
2004: Alina M Vrabioiu; Scott A Gerber; Steven P Gygi; Christine M Field; Timothy J Mitchison
The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides.
The Journal of biological chemistry 2004;279(4):3111-8.
2003: Jiaxu Li; Hanno Steen; Steven P Gygi
Protein profiling with cleavable isotope-coded affinity tag (cICAT) reagents: the yeast salinity stress response.
Molecular & cellular proteomics : MCP 2003;2(11):1198-204.
2003: Amy L Hitchcock; Kathryn L Auld; Steven P Gygi; Pamela A Silver
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12735-40.
2003: Sudipto Das; John D Rafter; kwang pyo kim; Steven P Gygi; Wonhwa Cho
Mechanism of group IVA cytosolic phospholipase A(2) activation by phosphorylation.
The Journal of biological chemistry 2003;278(42):41431-42.
2003: Nika N Danial; Colette F Gramm; LUCA SCORRANO; Chen-Yu zhang; Stefan Krauss; Ann M Ranger; Sandeep Robert Datta; Michael E Greenberg; Lawrence J Licklider; Bradford B Lowell; Steven P Gygi; Stanley J Korsmeyer
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Nature 2003;424(6951):952-6.
2003: Bin Ye; Daniel W Cramer; Steven J Skates; Steven P Gygi; Vanessa Pratomo; Lanfei Fu; Nora K Horick; Lawrence J Licklider; John O Schorge; Ross S Berkowitz; Samuel C Mok
Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):2904-11.
2003: Junmin Peng; Daniel Schwartz; Josh Elias; Carson C Thoreen; Dongmei Cheng; Gerald Marsischky; Jeroen Roelofs; Daniel Finley; Steven P Gygi
A proteomics approach to understanding protein ubiquitination.
Nature biotechnology 2003;21(8):921-6.
2003: Aswini K Panigrahi; Thomas E Allen; Kenneth Stuart; Paul A Haynes; Steven P Gygi
Mass spectrometric analysis of the editosome and other multiprotein complexes in Trypanosoma brucei.
Journal of the American Society for Mass Spectrometry 2003;14(7):728-35.
2003: Scott A Gerber; John Rush; Olaf Stemman; Marc W Kirschner; Steven P Gygi
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):6940-5.
2003: Nagi Ayad; Susannah Rankin; Monica Murakami; Judith A Jebanathirajah; Steven P Gygi; Marc W Kirschner
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Cell 2003;113(1):101-13.
2003: Junmin Peng; Josh Elias; Carson C Thoreen; Lawrence J Licklider; Steven P Gygi
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Journal of proteome research 2003;2(1):43-50.
2002: Jiaxu Li; Danesh Moazed; Steven P Gygi
Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.
The Journal of biological chemistry 2002;277(51):49383-8.
2002: Zhaolan Zhou; Lawrence J Licklider; Steven P Gygi; Robin Reed
Comprehensive proteomic analysis of the human spliceosome.
Nature 2002;419(6903):182-5.
2002: Hookeun Lee; Timothy J Griffin; Steven P Gygi; Beate Rist; Ruedi Aebersold
Development of a multiplexed microcapillary liquid chromatography system for high-throughput proteome analysis.
Analytical chemistry 2002;74(17):4353-60.
2002: Jiaxu Li; Toshinori Kinoshita; Sona Pandey; Carl K-Y Ng; Steven P Gygi; Ken-ichiro Shimazaki; Sarah M Assmann
Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase.
Nature 2002;418(6899):793-7.
2002: Lawrence J Licklider; Carson C Thoreen; Junmin Peng; Steven P Gygi
Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column.
Analytical chemistry 2002;74(13):3076-83.
2002: Georg J Hoppe; Jason Tanny; Adam D Rudner; Scott A Gerber; Sherwin Danaie; Steven P Gygi; Danesh Moazed
Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.
Molecular and cellular biology 2002;22(12):4167-80.
2002: Eric A James; Steven P Gygi; Michael L Adams; Robert H Pierce; Nelson Fausto; Ruedi Aebersold; Sidney D Nelson; Sam A Bruschi
Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.
Biochemistry 2002;41(21):6789-97.
2002: Timothy J Griffin; Steven P Gygi; Trey Ideker; Beate Rist; Jimmy Eng; Leroy Hood; Ruedi Aebersold
Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae.
Molecular & cellular proteomics : MCP 2002;1(4):323-33.
2002: Jessica A Hamerman; Fumitaka Hayashi; Lea A Schroeder; Steven P Gygi; Arthur L Haas; Lynne Hampson; Paul B Coughlin; Ruedi Aebersold; Alan Aderem
Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2415-23.
2002: Steven P Gygi; Beate Rist; Timothy J Griffin; Jimmy Eng; Ruedi Aebersold
Proteome analysis of low-abundance proteins using multidimensional chromatography and isotope-coded affinity tags.
Journal of proteome research 2002;1(1):47-54.
2001: Olaf Stemmann; Hui Zou; Scott A Gerber; Steven P Gygi; Marc W Kirschner
Dual inhibition of sister chromatid separation at metaphase.
Cell 2001;107(6):715-26.
2001: Timothy J Griffin; D K Han; Steven P Gygi; Beate Rist; Hookeun Lee; Ruedi Aebersold; K C Parker
Toward a high-throughput approach to quantitative proteomic analysis: expression-dependent protein identification by mass spectrometry.
Journal of the American Society for Mass Spectrometry 2001;12(12):1238-46.
2001: Aswini K Panigrahi; Achim Schnaufer; Nicole Carmean; Robert P Igo; Steven P Gygi; Nancy Lewis Ernst; Setareh S Palazzo; David S Weston; R Aebersold; Reza Salavati; Kenneth D Stuart
Four related proteins of the Trypanosoma brucei RNA editing complex.
Molecular and cellular biology 2001;21(20):6833-40.
2001: M L Mayer; Steven P Gygi; R Aebersold; Philip Hieter
Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.
Molecular cell 2001;7(5):959-70.
2001: Timothy J Griffin; Steven P Gygi; Beate Rist; Ruedi Aebersold; Alexander Loboda; A Jilkine; Werner Ens; Kenneth G Standing
Quantitative proteomic analysis using a MALDI quadrupole time-of-flight mass spectrometer.
Analytical chemistry 2001;73(5):978-86.
2001: Aswini K Panigrahi; Steven P Gygi; Nancy Lewis Ernst; Robert P Igo; Setareh S Palazzo; Achim Schnaufer; David S Weston; Nicole Carmean; Reza Salavati; R Aebersold; Kenneth D Stuart
Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complex.
Molecular and cellular biology 2001;21(2):380-9.
2000: Steven P Gygi; Ruedi Aebersold
Mass spectrometry and proteomics.
Current opinion in chemical biology 2000;4(5):489-94.
2000: Steven P Gygi; Garry L Corthals; Y Zhang; YP Rochon; Ruedi Aebersold
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9390-5.
2000: Steven P Gygi; Beate Rist; Ruedi Aebersold
Measuring gene expression by quantitative proteome analysis.
Current opinion in biotechnology 2000;11(4):396-401.
2000: Ruedi Aebersold; Beate Rist; Steven P Gygi
Quantitative proteome analysis: methods and applications.
Annals of the New York Academy of Sciences 2000;919():33-47.
1999: Steven P Gygi; Beate Rist; SA Gerber; Frantisek Turecek; Michael H Gelb; Ruedi Aebersold
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags.
Nature biotechnology 1999;17(10):994-9.
1999: Steven P Gygi; YP Rochon; B R Franza; Ruedi Aebersold
Correlation between protein and mRNA abundance in yeast.
Molecular and cellular biology 1999;19(3):1720-30.
1999: Steven P Gygi; Ruedi Aebersold
Absolute quantitation of 2-D protein spots.
Methods in molecular biology (Clifton, N.J.) 1999;112():417-21.
1998: D Figeys; Steven P Gygi; G McKinnon; Ruedi Aebersold
An integrated microfluidics-tandem mass spectrometry system for automated protein analysis.
Analytical chemistry 1998;70(18):3728-34.
1998: Ruedi Aebersold; D Figeys; Steven P Gygi; Garry L Corthals; P Haynes; Beate Rist; J Sherman; Y Zhang; David R Goodlett
Towards an integrated analytical technology for the generation of multidimensional protein expression maps.
Journal of protein chemistry 1998;17(6):533-5.