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Claude Haan

Research Profile

Chemicals & Drugs

Physiology

Signal Transduction

Anatomy

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Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Karoline Gäbler; Iris Behrmann; Guy Berchem; René Eulenfeld; Jakub Kaczor; Sergio Álvarez Méndez; Valérie Palissot; Catherine Rolvering; Claude Haan
Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F.
Serge Haan; Claude Haan
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.
Claude Haan; Serge Haan
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.

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All Publications

2013: Karoline Gäbler; Iris Behrmann; Guy Berchem; René Eulenfeld; Jakub Kaczor; Sergio Álvarez Méndez; Valérie Palissot; Catherine Rolvering; Claude Haan
Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F.
Journal of cellular and molecular medicine 2013;17(2):265-76.
2013: Serge Haan; Claude Haan
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.
Methods in molecular biology (Clifton, N.J.) 2013;967():147-59.
2013: Claude Haan; Serge Haan
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.
Methods in molecular biology (Clifton, N.J.) 2013;967():21-38.
2010: Stefan Vollmer; Claude Haan; Iris Behrmann
Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells.
Biochemical pharmacology 2010;80(12):2066-73.
2010: Claude Haan; Iris Behrmann; Serge Haan
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Journal of cellular and molecular medicine 2010;14(3):504-27.
2009: Serge Haan; Stefan Wüller; J Kaczor; C Rolvering; T Nöcker; Iris Behrmann; Claude Haan
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Oncogene 2009;28(34):3069-80.
2009: Herdis Bender; Monique Y Wiesinger; Carolin Nordhoff; Caroline Schoenherr; Claude Haan; Stephan Ludwig; Ralf Weiskirchen; Nobuyuki Kato; Peter C Heinrich; Serge Haan
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Hepatology (Baltimore, Md.) 2009;50(2):585-91.
2009: Stefan Vollmer; Valérie Kappler; Jakub Kaczor; Daniela Flügel; Catherine Rolvering; Nobuyuki Kato; Thomas Kietzmann; Iris Behrmann; Claude Haan
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling.
Hepatology (Baltimore, Md.) 2009;50(1):253-60.
2009: Claude Haan; Daniela C Kroy; Stefan Wüller; Ulrike Sommer; Tanja Nöcker; Catherine Rolvering; Iris Behrmann; Peter C Heinrich; Serge Haan
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2969-77.
2008: Serge Haan; Christiane Margue; Arnaud Engrand; Catherine Rolvering; Hildegard Schmitz-Van De Leur; Peter C Heinrich; Iris Behrmann; Claude Haan
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):998-1007.
2007: Claude Haan; Iris Behrmann
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background.
Journal of immunological methods 2007;318(1-2):11-9.
2007: Stephanie Kreis; Demetra Philippidou; Christiane Margue; Catherine Rolvering; Claude Haan; Laure Dumoutier; Jean-Christophe Renauld; Iris Behrmann
Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.
PloS one 2007;2(12):e1300.
2006: Claude Haan; Stephanie Kreis; Christiane Margue; Iris Behrmann
Jaks and cytokine receptors--an intimate relationship.
Biochemical pharmacology 2006;72(11):1538-46.
2005: Serge Haan; Julia F Keller; Iris Behrmann; Peter C Heinrich; Claude Haan
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.
Cellular signalling 2005;17(12):1542-50.
2005: Simone Radtke; Serge Haan; Angela Jörissen; Heike M Hermanns; Sandra Diefenbach; Tanya Smyczek; Hildegard Schmitz-Vandeleur; Peter C Heinrich; Iris Behrmann; Claude Haan
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.
The Journal of biological chemistry 2005;280(27):25760-8.
2004: Iris Behrmann; Tanya Smyczek; Peter C Heinrich; Hildegard Schmitz-Van De Leur; Waraporn Komyod; Bernd Giese; Gerhard Müller-Newen; Serge Haan; Claude Haan
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.
The Journal of biological chemistry 2004;279(34):35486-93.
2003: Bernd Giese; Chi-King Au-Yeung; Andreas Herrmann; Sandra Diefenbach; Claude Haan; Andrea Küster; Saskia B Wortmann; Christoph Roderburg; Peter C Heinrich; Iris Behrmann; Gerhard Müller-Newen
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.
The Journal of biological chemistry 2003;278(40):39205-13.
2002: Simone Radtke; Heike M Hermanns; Claude Haan; Hildegard Schmitz-Van De Leur; Hugues Gascan; Peter C Heinrich; Iris Behrmann
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.
The Journal of biological chemistry 2002;277(13):11297-305.
2002: Claude Haan; Peter C Heinrich; Iris Behrmann
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.
The Biochemical journal 2002;361(Pt 1):105-11.
2001: Claude Haan; Hayaatun Is'harc; Heike M Hermanns; Hildegard Schmitz-Van De Leur; Ian M Kerr; Peter C Heinrich; Joachim Grötzinger; Iris Behrmann
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction.
The Journal of biological chemistry 2001;276(40):37451-8.
2000: Peter C Heinrich; Johannes Bode; Lutz Graeve; Claude Haan; Astrid S Martens; Gerhard Müller-Newen; Ariane Nimmesgern; Fred Schaper; Jochen Schmitz; Elmar Siewert
Modulation and termination of interleukin-6 signalling.
European cytokine network 2000;11(3):512-3.
2000: Iris Behrmann; Heike M Hermanns; Claude Haan; Marcin Kortylewski; Simone Radtke; J Greiser; Peter C Heinrich
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor.
European cytokine network 2000;11(3):491-2.
2000: Claude Haan; Heike M Hermanns; Peter C Heinrich; Iris Behrmann
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.
The Biochemical journal 2000;349(Pt 1):261-6.
2000: S Thiel; Ulrike Sommer; Marcin Kortylewski; Claude Haan; Iris Behrmann; Peter C Heinrich; Lutz Graeve
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis.
FEBS letters 2000;470(1):15-9.
1999: Heike M Hermanns; Simone Radtke; Claude Haan; Hildegard Schmitz-Van De Leur; Jan Tavernier; Peter C Heinrich; Iris Behrmann
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6651-8.