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Serge Haan

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Serge Haan; Claude Haan
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.
Claude Haan; Serge Haan
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.
Claude Haan; Iris Behrmann; Serge Haan
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.

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All Publications

2013: Serge Haan; Claude Haan
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.
Methods in molecular biology (Clifton, N.J.) 2013;967():147-59.
2013: Claude Haan; Serge Haan
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.
Methods in molecular biology (Clifton, N.J.) 2013;967():21-38.
2010: Claude Haan; Iris Behrmann; Serge Haan
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Journal of cellular and molecular medicine 2010;14(3):504-27.
2010: Caroline Schoenherr; Ralf Weiskirchen; Serge Haan
Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses.
Cell communication and signaling : CCS 2010;8():19.
2009: Serge Haan; Stefan Wüller; J Kaczor; C Rolvering; T Nöcker; Iris Behrmann; Claude Haan
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Oncogene 2009;28(34):3069-80.
2009: Herdis Bender; Monique Y Wiesinger; Carolin Nordhoff; Caroline Schoenherr; Claude Haan; Stephan Ludwig; Ralf Weiskirchen; Nobuyuki Kato; Peter C Heinrich; Serge Haan
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Hepatology (Baltimore, Md.) 2009;50(2):585-91.
2009: Monique Y Wiesinger; Serge Haan; Stefan Wüller; Maria-Elisabeth Kauffmann; Tobias Recker; Andrea Küster; Peter C Heinrich; Gerhard Müller-Newen
Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).
Chemistry & biology 2009;16(7):783-94.
2009: Claude Haan; Daniela C Kroy; Stefan Wüller; Ulrike Sommer; Tanja Nöcker; Catherine Rolvering; Iris Behrmann; Peter C Heinrich; Serge Haan
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2969-77.
2008: Serge Haan; Christiane Margue; Arnaud Engrand; Catherine Rolvering; Hildegard Schmitz-Van De Leur; Peter C Heinrich; Iris Behrmann; Claude Haan
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):998-1007.
2007: Stephanie Kreis; Georg A Munz; Serge Haan; Peter C Heinrich; Iris Behrmann
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.
Molecular cancer research : MCR 2007;5(12):1331-41.
2007: Andreas Herrmann; Michael Vogt; Martin Mönnigmann; Thomas Clahsen; Ulrike Sommer; Serge Haan; Valeria Poli; Peter C Heinrich; Gerhard Müller-Newen
Nucleocytoplasmic shuttling of persistently activated STAT3.
Journal of cell science 2007;120(Pt 18):3249-61.
2006: Ute Lehmann; Ulrike Sommer; Tanya Smyczek; Michael Hörtner; Wiltrud Frisch; Rudolf Volkmer-Engert; Peter C Heinrich; Fred Schaper; Serge Haan
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.
Cellular signalling 2006;18(1):40-9.
2005: Serge Haan; Julia F Keller; Iris Behrmann; Peter C Heinrich; Claude Haan
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.
Cellular signalling 2005;17(12):1542-50.
2005: Ulrike Sommer; Christine Schmid; Radoslaw M Sobota; Ute Lehmann; Nigel J Stevenson; James A Johnston; Fred Schaper; Peter C Heinrich; Serge Haan
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
The Journal of biological chemistry 2005;280(36):31478-88.
2005: Simone Radtke; Serge Haan; Angela Jörissen; Heike M Hermanns; Sandra Diefenbach; Tanya Smyczek; Hildegard Schmitz-Vandeleur; Peter C Heinrich; Iris Behrmann; Claude Haan
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.
The Journal of biological chemistry 2005;280(27):25760-8.
2005: Waraporn Komyod; Uta-Maria Bauer; Peter C Heinrich; Serge Haan; Iris Behrmann
Are STATS arginine-methylated?
The Journal of biological chemistry 2005;280(23):21700-5.
2005: Heike M Hermanns; Gerhard Müller-Newen; Peter C Heinrich; Serge Haan
Bow to your partner for signaling.
Nature structural & molecular biology 2005;12(6):476-8.
2004: Nigel J Stevenson; Serge Haan; Angela E McClurg; Michael J McGrattan; Marilyn A Armstrong; Peter C Heinrich; James A Johnston
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3243-9.
2004: Iris Behrmann; Tanya Smyczek; Peter C Heinrich; Hildegard Schmitz-Van De Leur; Waraporn Komyod; Bernd Giese; Gerhard Müller-Newen; Serge Haan; Claude Haan
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase.
The Journal of biological chemistry 2004;279(34):35486-93.
2004: Patrick Fischer; Ute Lehmann; Radoslaw M Sobota; Jochen Schmitz; Claudia Niemand; Sonja Linnemann; Serge Haan; Iris Behrmann; Akihiko Yoshimura; James A Johnston; Gerhard Müller-Newen; Peter C Heinrich; Fred Schaper
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
The Biochemical journal 2004;378(Pt 2):449-60.
2004: Andreas Herrmann; Ulrike Sommer; Albert L Pranada; Bernd Giese; Andrea Küster; Serge Haan; Walter Becker; Peter C Heinrich; Gerhard Müller-Newen
STAT3 is enriched in nuclear bodies.
Journal of cell science 2004;117(Pt 2):339-49.
2003: Serge Haan; Paul Ferguson; Ulrike Sommer; Meena Hiremath; Daniel W McVicar; Peter C Heinrich; James A Johnston; Nicholas A Cacalano
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
The Journal of biological chemistry 2003;278(34):31972-9.
2003: Peter C Heinrich; Iris Behrmann; Serge Haan; Heike M Hermanns; Gerhard Müller-Newen; Fred Schaper
Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
The Biochemical journal 2003;374(Pt 1):1-20.
2003: Cécile Ancey; Andrea Küster; Serge Haan; Andreas Herrmann; Peter C Heinrich; Gerhard Müller-Newen
A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.
The Journal of biological chemistry 2003;278(19):16968-72.
2003: Claudia Niemand; Ariane Nimmesgern; Serge Haan; Patrick Fischer; Fred Schaper; Rolf Rossaint; Peter C Heinrich; Gerhard Müller-Newen
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3263-72.
2002: Michael Hörtner; Ulrich Nielsch; Lorenz M Mayr; James A Johnston; Peter C Heinrich; Serge Haan
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1219-27.
2002: Michael Hörtner; Ulrich Nielsch; Lorenz M Mayr; Peter C Heinrich; Serge Haan
A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
European journal of biochemistry / FEBS 2002;269(10):2516-26.
2000: Jochen Schmitz; Manuela Weissenbach; Serge Haan; Peter C Heinrich; Fred Schaper
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
The Journal of biological chemistry 2000;275(17):12848-56.
2000: Serge Haan; Marcin Kortylewski; Iris Behrmann; W Müller-Esterl; Peter C Heinrich; Fred Schaper
Cytoplasmic STAT proteins associate prior to activation.
The Biochemical journal 2000;345 Pt 3():417-21.
1999: Serge Haan; U Hemmann; U Hassiepen; Fred Schaper; Jens Schneider-Mergener; Axel Wollmer; Peter C Heinrich; Joachim Grötzinger
Characterization and binding specificity of the monomeric STAT3-SH2 domain.
The Journal of biological chemistry 1999;274(3):1342-8.