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Christian Haass

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Chemicals & Drugs

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Alzheimer's Disease

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Daniel Fleck; Chiara Galante; Alessio Colombo; Dieter Edbauer; Heike Hampel; Elisabeth Kremmer; Stefan F Lichtenthaler; Bozidar Novak; Linnea Rabe; Bettina Schmid; Benjamin M Schwenk; Sabina Tahirovic; Frauke van Bebber; Michael Willem; Christian Haass
Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling.
Sebastian Hogl; Peer-Hendrik Kuhn; Bastian Dislich; Christian Haass; Bettina Schmid; Frauke van Bebber; Stefan F Lichtenthaler
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Benedikt Kretner; Peer-Hendrik Kuhn; Stefan F Lichtenthaler; Blanca I Pérez-Revuelta; Akio Fukumori; Christian Haass; Harald Steiner
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

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All Publications

2013: Daniel Fleck; Chiara Galante; Alessio Colombo; Dieter Edbauer; Heike Hampel; Elisabeth Kremmer; Stefan F Lichtenthaler; Bozidar Novak; Linnea Rabe; Bettina Schmid; Benjamin M Schwenk; Sabina Tahirovic; Frauke van Bebber; Michael Willem; Christian Haass
Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(18):7856-69.
2013: Sebastian Hogl; Peer-Hendrik Kuhn; Bastian Dislich; Christian Haass; Bettina Schmid; Frauke van Bebber; Stefan F Lichtenthaler
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Proteomics 2013;13(9):1519-27.
2013: Benedikt Kretner; Peer-Hendrik Kuhn; Stefan F Lichtenthaler; Blanca I Pérez-Revuelta; Akio Fukumori; Christian Haass; Harald Steiner
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
Journal of neurochemistry 2013;125(1):144-56.
2013: Bettina Schmid; Barbara Solchenberger; Katrin Strecker; Mathias Teucke; Frauke van Bebber; Christine Van Broeckhoven; Julie van der Zee; Julia Banzhaf-Strathmann; Marc Cruts; Dieter Edbauer; Stefan Eimer; Laura Hasenkamp; Jan Hegermann; Sebastian Hogl; Alexander Hruscha; Maike Kittelmann; Elisabeth Kremmer; Stefan F Lichtenthaler; Christian Haass
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):4986-91.
2013: Kohji Mori; Kristin Rentzsch; Bettina Schmid; Christine Van Broeckhoven; Shih-Ming Weng; Christian Haass; Elisabeth Kremmer; Hans A Kretzschmar; Stephanie May; Thomas Arzberger; Marc Cruts; Dieter Edbauer
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
Science (New York, N.Y.) 2013;339(6125):1335-8.
2013: Kohji Mori; Manuela Neumann; Christine Van Broeckhoven; Sonja Zilow; Thomas Arzberger; Marc Cruts; Dieter Edbauer; Ignasi Forné; Jochen Herms; Jonathan Janssens; Gernot Kleinberger; Hans A Kretzschmar; Sven Lammich; Ian R A Mackenzie; Christian Haass
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.
Acta neuropathologica 2013;125(3):413-23.
2013: Marjorie Poggi; Marie-Christine Alessi; Bernadette Bonardo; Jean-Michel Brunel; Regina Fluhrer; Roland Govers; Christian Haass; Imène Kara; Jean-François Landrier; Franck Peiretti
Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling.
Biochimica et biophysica acta 2013;1833(3):602-12.
2012: Matthias Voss; Akio Fukumori; Gudula Grammer; Christian Haass; Martina Haug-Kröper; Bärbel Klier; Elisabeth Kremmer; Peer-Hendrik Kuhn; Ulrike Künzel; Stefan F Lichtenthaler; Bernd Schröder; Harald Steiner; Regina Fluhrer
Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).
The Journal of biological chemistry 2012;287(52):43401-9.
2012: Richard M Page; Orly Reiner; Harald Steiner; Michael Boutros; Alessio Colombo; Thomas Horn; Peer-Hendrik Kuhn; Stefan F Lichtenthaler; Anna Münch; Christian Haass
Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(50):18204-14.
2012: Dorothee Dormann; Claudia Abou-Ajram; Olaf Ansorge; Eva Bentmann; Elisabeth Kremmer; Ian R A Mackenzie; Tobias Madl; Manuela Neumann; Sabina Tahirovic; Chiara F Valori; Christian Haass
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.
The EMBO journal 2012;31(22):4258-75.
2012: Nicole Exner; Christian Haass; Anne Kathrin Lutz; Konstanze F Winklhofer
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.
The EMBO journal 2012;31(14):3038-62.
2012: Peer-Hendrik Kuhn; Stefan Bräse; Alessio Colombo; Christian Haass; Albrecht Hoffmeister; Sebastian Hogl; Axel imhof; Katarzyna Koroniak; Steffen Rossner; Ute Schepers; Christiane Volbracht; Michael Willem; Ulrike Zeitschel; Stefan F Lichtenthaler
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
The EMBO journal 2012;31(14):3157-68.
2012: Kathrin Grundmann; Christian Haass; Till-Karsten Hauser; Jasmin Hettich; Giuseppina Martella; Huu-Phuc Nguyen; Brigitte Nuscher; Bernd Pichler; Antonio Pisani; Olaf Riess; Martin Schaller; Giuseppe Sciamanna; Libo Yu; Zhenyu Yue; Salvador Castaneda; Birgit Fehrenbacher; Nicola Glöckle; Thomas Ott
Generation of a novel rodent model for DYT1 dystonia.
Neurobiology of disease 2012;47(1):61-74.
2012: Eva Bentmann; Dorothee Dormann; Manuela Neumann; Ramona Rodde; Sabina Tahirovic; Christian Haass
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).
The Journal of biological chemistry 2012;287(27):23079-94.
2012: Kristina Leuner; Sören Mai; Angelo Occhipinti; Richard D Palmiter; Andreas S Reichert; Carola Schiller; Tanja Schütt; Michael Willem; Ilka Wittig; Ulrich Brandt; Stefan Dröse; Gunter P Eckert; Schamim H Eckert; Christian Haass; Marina Jendrach; Shane E Kruse; Christopher Kurz; Walter E Müller
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.
Antioxidants & redox signaling 2012;16(12):1421-33.
2012: Christina M Lang; Benjamin M Schwenk; Elisabeth Kremmer; Peer-Hendrik Kuhn; Anja Capell; Dieter Edbauer; Katrin Fellerer; Christian Haass
Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.
The Journal of biological chemistry 2012;287(23):19355-65.
2012: Christian Haass; Christoph Kaether; Gopal Thinakaran; Sangram Sisodia
Trafficking and proteolytic processing of APP.
Cold Spring Harbor perspectives in medicine 2012;2(5):a006270.
2012: Regina Fluhrer; Gudula Grammer; Martina Haug-Kröper; Bärbel Klier; Lucas Martin; Brigitte Nuscher; Christian Haass
The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b).
The Journal of biological chemistry 2012;287(7):5156-63.
2012: Daniel Fleck; Alistair Garratt; Christian Haass; Michael Willem
BACE1 dependent neuregulin processing: review.
Current Alzheimer research 2012;9(2):178-83.
2011: Regina Fluhrer; Gudula Grammer; Frits Kamp; Brigitte Nuscher; Harald Steiner; Klaus Beyer; Christian Haass
The Nicastrin ectodomain adopts a highly thermostable structure.
Biological chemistry 2011;392(11):995-1001.
2011: Amelie Ebke; Akio Fukumori; Christian Haass; Thomas Luebbers; Keiro Shirotani; Karlheinz Baumann; Harald Steiner
Novel γ-secretase enzyme modulators directly target presenilin protein.
The Journal of biological chemistry 2011;286(43):37181-6.
2011: Manuela Neumann; Rosa Rademakers; Sigrun Roeber; Osamu Yokota; David G Munoz; Lee Cyn Ang; Olaf Ansorge; Eva Bentmann; Juan Bilbao; Mariely DeJesus-Hernandez; Dorothee Dormann; Christian Haass; Ali Jawaid; Hans A Kretzschmar; Hirofumi Kusaka; Ian R A Mackenzie
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
Brain : a journal of neurology 2011;134(Pt 9):2595-609.
2011: Stefan F Lichtenthaler; Christian Haass; Harald Steiner
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing.
Journal of neurochemistry 2011;117(5):779-96.
2011: Harshvardhan Rolyan; Ann Caroline Feike; Ajeet Rijal Upadhaya; Andreas Waha; Tom Van Dooren; Christian Haass; Gerd Birkenmeier; Claus U Pietrzik; Fred Van Leuven; Dietmar R Thal
Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(5):699-712.
2011: Benedikt Kretner; Akio Fukumori; Amelie Gutsmiedl; Richard M Page; Thomas Luebbers; Guido Galley; Karlheinz Baumann; Christian Haass; Harald Steiner
Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.
The Journal of biological chemistry 2011;286(17):15240-51.
2011: Anja Capell; Sabine Liebscher; Katrin Fellerer; Nathalie Brouwers; Michael Willem; Sven Lammich; Ilse Gijselinck; Tobias Bittner; Aaron M Carlson; Florenz Sasse; Brigitte Kunze; Heinrich Steinmetz; Rolf Jansen; Dorothee Dormann; Kristel Sleegers; Marc Cruts; Jochen Herms; Christine Van Broeckhoven; Christian Haass
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(5):1885-94.
2010: hans förstl; Christian Haass; Bernhard Hemmer; Bernhard Meyer; Martin Halle
Boxing-acute complications and late sequelae: from concussion to dementia.
Deutsches Ärzteblatt international 2010;107(47):835-9.
2010: Christian Haass
Initiation and propagation of neurodegeneration.
Nature medicine 2010;16(11):1201-4.
2010: Frits Kamp; Nicole Exner; Anne Kathrin Lutz; Nora Wender; Jan Hegermann; Bettina Brunner; Brigitte Nuscher; Tim Bartels; Armin Giese; Klaus Beyer; Stefan Eimer; Konstanze F Winklhofer; Christian Haass
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
The EMBO journal 2010;29(20):3571-89.
2010: Tim Bartels; Logan S Ahlstrom; Avigdor Leftin; Frits Kamp; Christian Haass; Michael F Brown; Klaus Beyer
The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding.
Biophysical journal 2010;99(7):2116-24.
2010: Frauke van Bebber; Dominik Paquet; Alexander Hruscha; Bettina Schmid; Christian Haass
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
Neurobiology of disease 2010;39(3):265-71.
2010: Ulf Dettmer; Peer-Hendrik Kuhn; Claudia Abou-Ajram; Stefan F Lichtenthaler; Marcus Krüger; Elisabeth Kremmer; Christian Haass; Christof Haffner
Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.
The Journal of biological chemistry 2010;285(34):26174-81.
2010: Dorothee Dormann; Ramona Rodde; Dieter Edbauer; Eva Bentmann; Ingeborg Fischer; Alexander Hruscha; Manuel E Than; Ian R A Mackenzie; Anja Capell; Bettina Schmid; Manuela Neumann; Christian Haass
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
The EMBO journal 2010;29(16):2841-57.
2010: Christian Haass; Eckhard Mandelkow
Fyn-tau-amyloid: a toxic triad.
Cell 2010;142(3):356-8.
2010: Stefan Mitterreiter; Richard M Page; Frits Kamp; Jessika Hopson; Edith Winkler; Huy Riem Ha; Runa Hamid; Jochen Herms; Thomas U Mayer; Deborah J Nelson; Harald Steiner; Tobias Stahl; Ulrike Zeitschel; Steffen Rossner; Christian Haass; Stefan F Lichtenthaler
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(26):8974-83.
2010: Akio Fukumori; Regina Fluhrer; Harald Steiner; Christian Haass
Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(23):7853-62.
2010: Richard M Page; Amelie Gutsmiedl; Akio Fukumori; Edith Winkler; Christian Haass; Harald Steiner
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
The Journal of biological chemistry 2010;285(23):17798-810.
2010: Sven Lammich; Dominik Buell; Sonja Zilow; Ann-Katrin Ludwig; Brigitte Nuscher; Stefan F Lichtenthaler; Claudia Prinzen; Falk Fahrenholz; Christian Haass
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.
The Journal of biological chemistry 2010;285(21):15753-60.
2010: Martin Fuhrmann; Tobias Bittner; Christian K E Jung; Steffen Burgold; Richard M Page; Gerda Mitteregger; Christian Haass; Frank M LaFerla; Hans A Kretzschmar; Jochen Herms
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
Nature neuroscience 2010;13(4):411-3.
2010: Blanca I Pérez-Revuelta; Akio Fukumori; Sven Lammich; Aya Yamasaki; Christian Haass; Harald Steiner
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
Journal of neurochemistry 2010;112(4):940-50.
2010: Matthias Fassler; Michael Zocher; Sebastian Klare; Alerie Guzman de la Fuente; Johanna Scheuermann; Anja Capell; Christian Haass; Christina Valkova; Anbazhagan Veerappan; Dirk Schneider; Christoph Kaether
Masking of transmembrane-based retention signals controls ER export of gamma-secretase.
Traffic (Copenhagen, Denmark) 2010;11(2):250-8.
2010: Mareike E Fett; Anna Pilsl; Dominik Paquet; Frauke van Bebber; Christian Haass; Jörg Tatzelt; Bettina Schmid; Konstanze F Winklhofer
Parkin is protective against proteotoxic stress in a transgenic zebrafish model.
PloS one 2010;5(7):e11783.
2010: Dominik Paquet; Bettina Schmid; Christian Haass
Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo.
Neuro-degenerative diseases 2010;7(1-3):99-102.
2010: Konstanze F Winklhofer; Christian Haass
Mitochondrial dysfunction in Parkinson's disease.
Biochimica et biophysica acta 2010;1802(1):29-44.
2009: A Kathrin Lutz; Nicole Exner; Mareike E Fett; Julia S Schlehe; Karina Kloos; Kerstin Lämmermann; Bettina Brunner; Annerose Kurz-Drexler; Frank Vogel; Andreas S Reichert; Lena Bouman; Daniela Vogt Weisenhorn; Wolfgang Wurst; Jörg Tatzelt; Christian Haass; Konstanze F Winklhofer
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
The Journal of biological chemistry 2009;284(34):22938-51.
2009: Tobias Bittner; Martin Fuhrmann; Steffen Burgold; Christian K E Jung; Christiane Volbracht; Harald Steiner; Gerda Mitteregger; Hans A Kretzschmar; Christian Haass; Jochen Herms
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(33):10405-9.
2009: Dorothee Dormann; Anja Capell; Aaron M Carlson; Sunita S Shankaran; Ramona Rodde; Manuela Neumann; Elisabeth Kremmer; Takashi Matsuwaki; Keitaro Yamanouchi; Masugi Nishihara; Christian Haass
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry 2009;110(3):1082-94.
2009: Kanta Yanagida; Masayasu Okochi; Shinji Tagami; Taisuke Nakayama; Takashi S Kodama; Kouhei Nishitomi; Jingwei Jiang; Kohji Mori; Shin-Ichi Tatsumi; Tetsuaki Arai; Takeshi Ikeuchi; Kensaku Kasuga; Takahiko Tokuda; Masaki Kondo; Masaki Ikeda; Kentaro Deguchi; Hiroaki Kazui; Toshihisa Tanaka; Takashi Morihara; Ryota Hashimoto; Takashi Kudo; Harald Steiner; Christian Haass; Kuniaki Tsuchiya; Haruhiko Akiyama; Ryozo Kuwano; Masatoshi Takeda
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
EMBO molecular medicine 2009;1(4):223-35.
2009: Regina Fluhrer; Harald Steiner; Christian Haass
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.
The Journal of biological chemistry 2009;284(21):13975-9.
2009: Dominik Paquet; Ratan Bhat; Astrid Sydow; Eva-Maria Mandelkow; Stefan Berg; Sven Hellberg; Johanna Fälting; Martin Distel; Reinhard W Köster; Bettina Schmid; Christian Haass
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation.
The Journal of clinical investigation 2009;119(5):1382-95.
2009: Michael Willem; Sven Lammich; Christian Haass
Function, regulation and therapeutic properties of beta-secretase (BACE1).
Seminars in cell & developmental biology 2009;20(2):175-82.
2009: Lucas Martin; Regina Fluhrer; Christian Haass
Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis.
The Journal of biological chemistry 2009;284(9):5662-70.
2009: Edith Winkler; Scott Hobson; Akio Fukumori; Birgit Dümpelfeld; Thomas Luebbers; Karlheinz Baumann; Christian Haass; Carsten Hopf; Harald Steiner
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Biochemistry 2009;48(6):1183-97.
2009: Naohiro Itoh; Masayasu Okochi; Shinji Tagami; Kouhei Nishitomi; Taisuke Nakayama; Kanta Yanagida; Akio Fukumori; Jingwei Jiang; Kohji Mori; Motoko Hosono; Jyunko Kikuchi; Yuko Nakano; Yoshihiko Takinami; Keiji Dohi; Atsuko Nishigaki; Hiroshi Takemoto; Kazuyuki Minagawa; Takaaki Katoh; Michael Willem; Christian Haass; Takashi Morihara; Toshihisa Tanaka; Takashi Kudo; Hiroshi Hasegawa; Masaki Nishimura; Gaku Sakaguchi; Akira Kato; Masatoshi Takeda
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Neuro-degenerative diseases 2009;6(5-6):230-9.
2009: Margot Fournier; Jeremie Vitte; Jérôme Garrigue; Dominique Langui; Jean-Philippe Dullin; Françoise Saurini; Naïma Hanoun; Fernando Perez-Diaz; Fabien Cornilleau; Chantal Joubert; Héctor Ardila-Osorio; Sabine Traver; René Duchateau; Cécile Goujet-Zalc; Katerina Paleologou; Hilal A Lashuel; Christian Haass; Charles Duyckaerts; Charles Cohen-Salmon; Philipp J Kahle; Michel Hamon; Alexis Brice; Olga Corti
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy.
PloS one 2009;4(8):e6629.
2008: Tracy O'Connor; Katherine R Sadleir; Erika Maus; rod velliquette; Jie Zhao; Sarah L Cole; William A Eimer; Brian Hitt; Leslie A Bembinster; Sven Lammich; Stefan F Lichtenthaler; Sébastien S Hébert; Bart De Strooper; Christian Haass; David A Bennett; Robert Vassar
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron 2008;60(6):988-1009.
2008: Harald Steiner; Edith Winkler; Christian Haass
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
The Journal of biological chemistry 2008;283(50):34677-86.
2008: Regina Fluhrer; Akio Fukumori; Lucas Martin; Gudula Grammer; Martina Haug-Kröper; Bärbel Klier; Edith Winkler; Elisabeth Kremmer; Margaret M Condron; David B Teplow; Harald Steiner; Christian Haass
Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.
The Journal of biological chemistry 2008;283(44):30121-8.
2008: Harald Steiner; Regina Fluhrer; Christian Haass
Intramembrane proteolysis by gamma-secretase.
The Journal of biological chemistry 2008;283(44):29627-31.
2008: Marc Aurel Busche; Gerhard Eichhoff; Helmuth Adelsberger; Dorothee Abramowski; Karl-Heinz Wiederhold; Christian Haass; Matthias Staufenbiel; Arthur Konnerth; Olga Garaschuk
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.
Science (New York, N.Y.) 2008;321(5896):1686-9.
2008: T Dejaegere; L Serneels; M K Schäfer; J Van Biervliet; K Horré; C Depboylu; Daniel Alvarez Fischer; A Herreman; M Willem; Christian Haass; G U Höglinger; R D'Hooge; Bart De Strooper
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9775-80.
2008: Peter St George-Hyslop; Christian Haass
Regulatory RNA goes awry in Alzheimer's disease.
Nature medicine 2008;14(7):711-2.
2008: Susanne Schöbel; Stephanie Neumann; Maren Hertweck; Bastian Dislich; Peer-Hendrik Kuhn; Elisabeth Kremmer; Brian Seed; Ralf Baumeister; Christian Haass; Stefan F Lichtenthaler
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
The Journal of biological chemistry 2008;283(21):14257-68.
2008: Konstanze F Winklhofer; Jörg Tatzelt; Christian Haass
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.
The EMBO journal 2008;27(2):336-49.
2008: Sunita S Shankaran; Anja Capell; Alexander T Hruscha; Katrin Fellerer; Manuela Neumann; Bettina Schmid; Christian Haass
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry 2008;283(3):1744-53.
2008: Lucas Martin; Regina Fluhrer; Karina Reiss; Elisabeth Kremmer; Paul Saftig; Christian Haass
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
The Journal of biological chemistry 2008;283(3):1644-52.
2008: Richard M Page; Karlheinz Baumann; Masanori Tomioka; Blanca I Pérez-Revuelta; Akio Fukumori; Helmut Jacobsen; Alexander Flohr; Thomas Luebbers; Laurence Ozmen; Harald Steiner; Christian Haass
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
The Journal of biological chemistry 2008;283(2):677-83.
2007: Toru Sato; Thekla S Diehl; Saravanakumar Narayanan; Satoru Funamoto; Yasuo Ihara; Bart De Strooper; Harald Steiner; Christian Haass; Michael S Wolfe
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry 2007;282(47):33985-93.
2007: Nicole Exner; Bettina Treske; Dominik Paquet; Kira Holmström; Carola Schiesling; Suzana Gispert; Iria Carballo-Carbajal; Daniela Berg; Hans-Hermann Hoepken; Thomas Gasser; Rejko Krüger; Konstanze F Winklhofer; Frank Vogel; Andreas S Reichert; Georg Auburger; Philipp J Kahle; Bettina Schmid; Christian Haass
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(45):12413-8.
2007: Christian Freichel; Manuela Neumann; Theresa M Ballard; Veronika Müller; Marie Woolley; Laurence Ozmen; Edilio Borroni; Hans A Kretzschmar; Christian Haass; Will Spooren; Philipp J Kahle
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.
Neurobiology of aging 2007;28(9):1421-35.
2007: Runa Hamid; Ellen Kilger; Michael Willem; Neville Vassallo; Markus Kostka; Carsten Bornhövd; Andreas S Reichert; Hans A Kretzschmar; Christian Haass; Jochen Herms
Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.
Journal of neurochemistry 2007;102(4):1264-75.
2007: Christoph Kaether; Johanna Scheuermann; Matthias Fassler; Sonja Zilow; Keiro Shirotani; Christina Valkova; Bozidar Novak; Slavomir Kacmar; Harald Steiner; Christian Haass
Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.
EMBO reports 2007;8(8):743-8.
2007: Dietmar R Thal; Sergey Larionov; Dorothee Abramowski; Karl-Heinz Wiederhold; Tom Van Dooren; Haruyasu Yamaguchi; Christian Haass; Fred Van Leuven; Matthias Staufenbiel; Estibaliz Capetillo-Zarate
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging 2007;28(8):1221-30.
2007: Keiro Shirotani; Masanori Tomioka; Elisabeth Kremmer; Christian Haass; Harald Steiner
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Neurobiology of disease 2007;27(1):102-7.
2007: Kai Prager; Lihua Wang-Eckhardt; Regina Fluhrer; Richard Killick; Esther Barth; Heike Hampel; Christian Haass; Jochen Walter
A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling.
The Journal of biological chemistry 2007;282(19):14083-93.
2007: Karin Görner; Eve Holtorf; Jens Waak; Thu-Trang Pham; Daniela Vogt Weisenhorn; Wolfgang Wurst; Christian Haass; Philipp J Kahle
Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1.
The Journal of biological chemistry 2007;282(18):13680-91.
2007: Peer-Hendrik Kuhn; Els Marjaux; Axel imhof; Bart De Strooper; Christian Haass; Stefan F Lichtenthaler
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.
The Journal of biological chemistry 2007;282(16):11982-95.
2007: Christof Haffner; Ulf Dettmer; Timotheus Weiler; Christian Haass
The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex.
The Journal of biological chemistry 2007;282(14):10632-8.
2007: Niclas W Schiffer; Sarah A Broadley; Thomas Hirschberger; Paul Tavan; Hans A Kretzschmar; Armin Giese; Christian Haass; F Ulrich Hartl; Bettina Schmid
Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model.
The Journal of biological chemistry 2007;282(12):9195-203.
2007: Christian Haass; Dennis J Selkoe
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Nature reviews. Molecular cell biology 2007;8(2):101-12.
2007: Regina Fluhrer; Christian Haass
Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
Neuro-degenerative diseases 2007;4(2-3):112-6.
2007: Rajeshwar Narlawar; Blanca I Pérez-Revuelta; Karlheinz Baumann; Robert Schubenel; Christian Haass; Harald Steiner; Boris Schmidt
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.
Bioorganic & medicinal chemistry letters 2007;17(1):176-82.
2006: Rajeshwar Narlawar; Blanca I Pérez-Revuelta; Christian Haass; Harald Steiner; Boris Schmidt; Karlheinz Baumann
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
Journal of medicinal chemistry 2006;49(26):7588-91.
2006: Estibaliz Capetillo-Zarate; Matthias Staufenbiel; Dorothee Abramowski; Christian Haass; Angelika Escher; Christine Stadelmann; Haruyasu Yamaguchi; Otmar D Wiestler; Dietmar R Thal
Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.
Brain : a journal of neurology 2006;129(Pt 11):2992-3005.
2006: Michael Willem; Alistair Garratt; Bozidar Novak; Martin Citron; Steve Kaufmann; Andrea Rittger; Bart DeStrooper; Paul Saftig; Carmen Birchmeier; Christian Haass
Control of peripheral nerve myelination by the beta-secretase BACE1.
Science (New York, N.Y.) 2006;314(5799):664-6.
2006: Rebecca Radde; Tristan Bolmont; Stephan A Kaeser; Janaky Coomaraswamy; Dennis Lindau; Lars Stoltze; Michael E Calhoun; Fabienne Jäggi; Hartwig Wolburg; Simon Gengler; Christian Haass; Bernardino Ghetti; Christian Czech; Christian Hölscher; Paul Mathews; Mathias Jucker
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.
EMBO reports 2006;7(9):940-6.
2006: Harald Steiner; Manuel Than; Wolfram Bode; Christian Haass
Pore-forming scissors? A first structural glimpse of gamma-secretase.
Trends in biochemical sciences 2006;31(9):491-3.
2006: Christine Wild-Bode; Katrin Fellerer; Johanna Kugler; Christian Haass; Anja Capell
A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.
The Journal of biological chemistry 2006;281(33):23824-9.
2006: Regina Fluhrer; Gudula Grammer; Lars Israel; Margaret M Condron; Christof Haffner; Elena Friedmann; Claudia Böhland; Axel imhof; Bruno Martoglio; David B Teplow; Christian Haass
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.
Nature cell biology 2006;8(8):894-6.
2006: Jesús Avila; Roger M Nitsch; Christian Haass; Bart De Strooper
European Alzheimer disease funding.
Nature medicine 2006;12(7):776-7.
2006: Claire Goldsbury; Maria-Magdalena Mocanu; Edda Thies; Christoph Kaether; Christian Haass; Patrick Keller; Jacek Biernat; Eckhard Mandelkow; Eva-Maria Mandelkow
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.
Traffic (Copenhagen, Denmark) 2006;7(7):873-88.
2006: Christopher Böhm; Nicole M Seibel; Birgit Henkel; Harald Steiner; Christian Haass; Wolfgang Hampe
SorLA signaling by regulated intramembrane proteolysis.
The Journal of biological chemistry 2006;281(21):14547-53.
2006: Lars Anders; Philipp Mertins; Sven Lammich; Marta Murgia; Dieter Hartmann; Paul Saftig; Christian Haass; Axel Ullrich
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Molecular and cellular biology 2006;26(10):3917-34.
2006: Akio Fukumori; Masayasu Okochi; Shinji Tagami; Jingwei Jiang; Naohiro Itoh; Taisuke Nakayama; Kanta Yanagida; Yoshiko Ishizuka-Katsura; Takashi Morihara; Kouzin Kamino; Toshihisa Tanaka; Takashi Kudo; Hisashi Tanii; Akiko Ikuta; Christian Haass; Masatoshi Takeda
Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.
Biochemistry 2006;45(15):4907-14.
2006: Aya Yamasaki; Stefan Eimer; Masayasu Okochi; Agata Smialowska; Christoph Kaether; Ralf Baumeister; Christian Haass; Harald Steiner
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3821-8.
2006: Christoph Kaether; Stephanie Schmitt; Michael Willem; Christian Haass
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
Traffic (Copenhagen, Denmark) 2006;7(4):408-15.
2006: Masayasu Okochi; Akio Fukumori; Jingwei Jiang; Naohiro Itoh; Ryo Kimura; Harald Steiner; Christian Haass; Shinji Tagami; Masatoshi Takeda
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
The Journal of biological chemistry 2006;281(12):7890-8.
2006: Stephanie Neumann; Susanne Schöbel; Sebastian Jäger; Anna Trautwein; Christian Haass; Claus U Pietrzik; Stefan F Lichtenthaler
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.
The Journal of biological chemistry 2006;281(11):7583-94.
2006: Christof Haffner; Christian Haass
Cellular functions of gamma-secretase-related proteins.
Neuro-degenerative diseases 2006;3(4-5):284-9.
2006: Christoph Kaether; Christian Haass; Harald Steiner
Assembly, trafficking and function of gamma-secretase.
Neuro-degenerative diseases 2006;3(4-5):275-83.
2005: Peter Krawitz; Christof Haffner; Regina Fluhrer; Harald Steiner; Bettina Schmid; Christian Haass
Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.
The Journal of biological chemistry 2005;280(47):39515-23.
2005: Dietmar R Thal; Estibaliz Capetillo-Zarate; Christian Schultz; Udo Rüb; Takaomi C Saido; Haruyasu Yamaguchi; Christian Haass; W Sue T Griffin; Kelly Del Tredici; Heiko Braak; Estifanos Ghebremedhin
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Acta neuropathologica 2005;110(5):459-71.
2005: Tobias Straub; Martin F Neumann; Matthias Prestel; Elisabeth Kremmer; Christoph Kaether; Christian Haass; Peter B Becker
Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment.
Chromosoma 2005;114(5):352-64.
2005: Armin Giese; Benedikt Bader; Jan Bieschke; Gregor Schaffar; Sabine Odoy; Philipp J Kahle; Christian Haass; Hans A Kretzschmar
Single particle detection and characterization of synuclein co-aggregation.
Biochemical and biophysical research communications 2005;333(4):1202-10.
2005: Stefan Prokop; Christian Haass; Harald Steiner
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Journal of neurochemistry 2005;94(1):57-62.
2005: Tina Wahle; Kai Prager; Nikolai A Raffler; Christian Haass; Michael Famulok; Jochen Walter
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.
Molecular and cellular neurosciences 2005;29(3):453-61.
2005: Christian X Andersson; Julia Fernandez-Rodriguez; Sirle Laos; Dan Baeckström; Christian Haass; Gunnar Hansson
Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.
The Biochemical journal 2005;387(Pt 2):377-84.
2005: Nadia Stefanova; Markus Reindl; Manuela Neumann; Christian Haass; Werner Poewe; Philipp J Kahle; Gregor Wenning
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.
The American journal of pathology 2005;166(3):869-76.
2005: Anja Capell; Dirk Beher; Stefan Prokop; Harald Steiner; Christoph Kaether; Mark S Shearman; Christian Haass
Gamma-secretase complex assembly within the early secretory pathway.
The Journal of biological chemistry 2005;280(8):6471-8.
2005: Armgard Uelhoff; Jörg Tatzelt; Adriano Aguzzi; Konstanze F Winklhofer; Christian Haass
A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.
The Journal of biological chemistry 2005;280(7):5137-40.
2005: Ayako Yamamoto; Arno Friedlein; Yuzuru Imai; Ryosuke Takahashi; Philipp J Kahle; Christian Haass
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.
The Journal of biological chemistry 2005;280(5):3390-9.
2004: Gil G Westmeyer; Michael Willem; Stefan F Lichtenthaler; Glenn Lurman; Gerd Multhaup; Irmgard Assfalg-Machleidt; Karina Reiss; Paul Saftig; Christian Haass
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
The Journal of biological chemistry 2004;279(51):53205-12.
2004: Christoph Kaether; Anja Capell; Dieter Edbauer; Edith Winkler; Bozidar Novak; Harald Steiner; Christian Haass
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
The EMBO journal 2004;23(24):4738-48.
2004: Christoph Kaether; Christian Haass
A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation.
The Journal of cell biology 2004;167(5):809-12.
2004: Manuela Neumann; Veronika Müller; Hans A Kretzschmar; Christian Haass; Philipp J Kahle
Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.
Journal of neuropathology and experimental neurology 2004;63(12):1225-35.
2004: Uta Keil; Astrid Bonert; Celio A Marques; Isabel Scherping; Jörg Weyermann; Joanna B Strosznajder; Franz Müller-Spahn; Christian Haass; Christian Czech; Laurent Pradier; Walter E Müller; Anne Eckert
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis.
The Journal of biological chemistry 2004;279(48):50310-20.
2004: Michael Willem; Ilse Dewachter; Neil Smyth; Tom Van Dooren; Peter Borghgraef; Christian Haass; Fred Van Leuven
beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice.
The American journal of pathology 2004;165(5):1621-31.
2004: Keiro Shirotani; Dieter Edbauer; Stefan Prokop; Christian Haass; Harald Steiner
Identification of distinct gamma-secretase complexes with different APH-1 variants.
The Journal of biological chemistry 2004;279(40):41340-5.
2004: Ariane Schmechel; Markus Strauss; Andrea Schlicksupp; Rüdiger Pipkorn; Christian Haass; Thomas A Bayer; Gerd Multhaup
Human BACE forms dimers and colocalizes with APP.
The Journal of biological chemistry 2004;279(38):39710-7.
2004: Dieter Edbauer; Christoph Kaether; Harald Steiner; Christian Haass
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
The Journal of biological chemistry 2004;279(36):37311-5.
2004: Christof Haffner; Mélanie Frauli; Stephanie Topp; Martin Irmler; Kay Hofmann; Jörg T Regula; Laure Bally-Cuif; Christian Haass
Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.
The EMBO journal 2004;23(15):3041-50.
2004: Philipp J Kahle; Christian Haass
How does parkin ligate ubiquitin to Parkinson's disease?
EMBO reports 2004;5(7):681-5.
2004: Keiro Shirotani; Dieter Edbauer; Marcus Kostka; Harald Steiner; Christian Haass
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Journal of neurochemistry 2004;89(6):1520-7.
2004: Sven Lammich; Susanne Schöbel; Ann-Katrin Zimmer; Stefan F Lichtenthaler; Christian Haass
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.
EMBO reports 2004;5(6):620-5.
2004: Manuela Neumann; Veronika Müller; Karin Görner; Hans A Kretzschmar; Christian Haass; Philipp J Kahle
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.
Acta neuropathologica 2004;107(6):489-96.
2004: Stefan Prokop; Keiro Shirotani; Dieter Edbauer; Christian Haass; Harald Steiner
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.
The Journal of biological chemistry 2004;279(22):23255-61.
2004: Brigitte Nuscher; Frits Kamp; Thomas Mehnert; Sabine Odoy; Christian Haass; Philipp J Kahle; Klaus Beyer
Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.
The Journal of biological chemistry 2004;279(21):21966-75.
2004: Stefan F Lichtenthaler; Christian Haass
Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model.
The Journal of clinical investigation 2004;113(10):1384-7.
2004: Karin Görner; Eve Holtorf; Sabine Odoy; Brigitte Nuscher; Ayako Yamamoto; Jörg T Regula; Klaus Beyer; Christian Haass; Philipp J Kahle
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.
The Journal of biological chemistry 2004;279(8):6943-51.
2004: Christian Haass
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.
The EMBO journal 2004;23(3):483-8.
2004: Regina Fluhrer; Arno Friedlein; Christian Haass; Jochen Walter
Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.
The Journal of biological chemistry 2004;279(3):1585-93.
2004: Christof Haffner; Christian Haass
The biochemical and genetic odyssey to the function of a nicastrin-like protein.
Neuro-degenerative diseases 2004;1(4-5):192-5.
2003: Anja Capell; Christoph Kaether; Dieter Edbauer; Keiro Shirotani; Sabine Merkl; Harald Steiner; Christian Haass
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.
The Journal of biological chemistry 2003;278(52):52519-23.
2003: Stefan F Lichtenthaler; Diana-Ines Dominguez; Gil G Westmeyer; Karina Reiss; Christian Haass; Paul Saftig; Bart De Strooper; Brian Seed
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
The Journal of biological chemistry 2003;278(49):48713-9.
2003: Adriano Aguzzi; Christian Haass
Games played by rogue proteins in prion disorders and Alzheimer's disease.
Science (New York, N.Y.) 2003;302(5646):814-8.
2003: Celio A Marques; Uta Keil; Astrid Bonert; Barbara Steiner; Christian Haass; Walter E Muller; Anne Eckert
Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.
The Journal of biological chemistry 2003;278(30):28294-302.
2003: Toru Sato; Naoshi Dohmae; Yue Qi; Nobuto Kakuda; Hiroaki Misono; Rie Mitsumori; Hiroko Maruyama; Edward H Koo; Christian Haass; Koji Takio; Maho Morishima-Kawashima; Shoichi Ishiura; Yasuo Ihara
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(27):24294-301.
2003: Keiro Shirotani; Dieter Edbauer; Anja Capell; Julia Schmitz; Harald Steiner; Christian Haass
Gamma-secretase activity is associated with a conformational change of nicastrin.
The Journal of biological chemistry 2003;278(19):16474-7.
2003: Dieter Edbauer; Edith Winkler; Joerg T Regula; Brigitte Pesold; Harald Steiner; Christian Haass
Reconstitution of gamma-secretase activity.
Nature cell biology 2003;5(5):486-8.
2003: Regina Fluhrer; Gerd Multhaup; Andrea Schlicksupp; Masayasu Okochi; Masatoshi Takeda; Sven Lammich; Michael Willem; Gil G Westmeyer; Wolfram Bode; Jochen Walter; Christian Haass
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
The Journal of biological chemistry 2003;278(8):5531-8.
2003: Robert Ehehalt; Patrick Keller; Christian Haass; Christoph Thiele; Kai Simons
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts.
The Journal of cell biology 2003;160(1):113-23.
2002: Christian Haass; Harald Steiner
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
Trends in cell biology 2002;12(12):556-62.
2002: Sven Lammich; Masayasu Okochi; Masatoshi Takeda; Christoph Kaether; Anja Capell; Ann-Katrin Zimmer; Dieter Edbauer; Jochen Walter; Harald Steiner; Christian Haass
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
The Journal of biological chemistry 2002;277(47):44754-9.
2002: Manuela Neumann; Philipp J Kahle; Benoit I Giasson; Laurence Ozmen; Edilio Borroni; Will Spooren; Veronika Müller; Sabine Odoy; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; John Q Trojanowski; Hans A Kretzschmar; Christian Haass
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
The Journal of clinical investigation 2002;110(10):1429-39.
2002: Christian Haass
New hope for Alzheimer disease vaccine.
Nature medicine 2002;8(11):1195-6.
2002: Harald Steiner; Edith Winkler; Dieter Edbauer; Stefan Prokop; Gabriele Basset; Aya Yamasaki; Marcus Kostka; Christian Haass
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
The Journal of biological chemistry 2002;277(42):39062-5.
2002: Masayasu Okochi; Harald Steiner; Akio Fukumori; Hisashi Tanii; Taisuke Tomita; Toshihisa Tanaka; Takeshi Iwatsubo; Takashi Kudo; Masatoshi Takeda; Christian Haass
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
The EMBO journal 2002;21(20):5408-16.
2002: Christoph Kaether; Sven Lammich; Dieter Edbauer; Michaela Ertl; Jens Rietdorf; Anja Capell; Harald Steiner; Christian Haass
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
The Journal of cell biology 2002;158(3):551-61.
2002: Philipp J Kahle; Christian Haass; Hans A Kretzschmar; Manuela Neumann
Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases.
Journal of neurochemistry 2002;82(3):449-57.
2002: Andrea Geling; Harald Steiner; Michael Willem; Laure Bally-Cuif; Christian Haass
A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.
EMBO reports 2002;3(7):688-94.
2002: Dieter Edbauer; Edith Winkler; Christian Haass; Harald Steiner
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8666-71.
2002: Tobias Moehlmann; Edith Winkler; Xuefeng Xia; Dieter Edbauer; Jill Murrell; Anja Capell; Christoph Kaether; Hui Zheng; Bernardino Ghetti; Christian Haass; Harald Steiner
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8025-30.
2002: Regina Fluhrer; Anja Capell; Gil G Westmeyer; Michael Willem; Bianka Hartung; Margaret M Condron; David B Teplow; Christian Haass; Jochen Walter
A non-amyloidogenic function of BACE-2 in the secretory pathway.
Journal of neurochemistry 2002;81(5):1011-20.
2002: Steffen Leutz; Barbara Steiner; Celio A Marques; Christian Haass; Walter E Müller; Anne Eckert
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death.
Journal of molecular neuroscience : MN 2002;18(3):189-201.
2002: Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Veronika Muller; Helmut Jacobsen; Will Spooren; Babette Fuss; Barbara S Mallon; Wendy B Macklin; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; Hans A Kretzschmar; Christian Haass
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
EMBO reports 2002;3(6):583-8.
2002: Dieter Edbauer; Michael Willem; Sven Lammich; Harald Steiner; Christian Haass
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).
The Journal of biological chemistry 2002;277(16):13389-93.
2002: Anja Capell; Liane Meyn; Regina Fluhrer; David B Teplow; Jochen Walter; Christian Haass
Apical sorting of beta-secretase limits amyloid beta-peptide production.
The Journal of biological chemistry 2002;277(7):5637-43.
2002: Dietmar R Thal; Estifanos Ghebremedhin; Christian Haass; Christian Schultz
UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain.
Clinical neuropathology 2002;21(1):35-40.
2001: Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Veronika Müller; Sabine Odoy; N Okamoto; Helmut Jacobsen; Takeshi Iwatsubo; John Q Trojanowski; H Takahashi; K Wakabayashi; Nenad Bogdanovic; Peter Riederer; Hans A Kretzschmar; Christian Haass
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.
The American journal of pathology 2001;159(6):2215-25.
2001: Harald Steiner; Christian Haass
Nuclear signaling: a common function of presenilin substrates?
Journal of molecular neuroscience : MN 2001;17(2):193-8.
2001: J Walter; Christoph Kaether; H Steiner; Christian Haass
The cell biology of Alzheimer's disease: uncovering the secrets of secretases.
Current opinion in neurobiology 2001;11(5):585-90.
2001: Christian Haass; H Steiner
Protofibrils, the unifying toxic molecule of neurodegenerative disorders?
Nature neuroscience 2001;4(9):859-60.
2001: M Sastre; Harald Steiner; K Fuchs; Anja Capell; Gerd Multhaup; Margaret M Condron; David B Teplow; Christian Haass
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.
EMBO reports 2001;2(9):835-41.
2001: Harald Steiner; E Winkler; M S Shearman; R Prywes; Christian Haass
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Neurobiology of disease 2001;8(4):717-22.
2001: Christian Haass; Philipp J Kahle
Neuroscience. Parkin and its substrates.
Science (New York, N.Y.) 2001;293(5528):224-5.
2001: Jochen Walter; Regina Fluhrer; B Hartung; Michael Willem; Christoph Kaether; Anja Capell; Sven Lammich; Gerd Multhaup; Christian Haass
Phosphorylation regulates intracellular trafficking of beta-secretase.
The Journal of biological chemistry 2001;276(18):14634-41.
2001: Silvia Rathke-Hartlieb; Philipp J Kahle; Manuela Neumann; Laurence Ozmen; S Haid; Masayasu Okochi; Christian Haass; Jörg B Schulz
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.
Journal of neurochemistry 2001;77(4):1181-4.
2001: Anne Eckert; Barbara Steiner; C Marques; Steffen Leutz; H Romig; Christian Haass; Walter E Müller
Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.
Journal of neuroscience research 2001;64(2):183-92.
2001: Harald Steiner; Tamas Revesz; M Neumann; H Romig; MG Grim; B Pesold; Hans A Kretzschmar; John Hardy; Janice L Holton; Ralf Baumeister; Henry Houlden; Christian Haass
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
The Journal of biological chemistry 2001;276(10):7233-9.
2001: Michael S Wolfe; Christian Haass
The Role of presenilins in gamma-secretase activity.
The Journal of biological chemistry 2001;276(8):5413-6.
2001: Tadashi Yamazaki; T Y Chang; Christian Haass; Yasuo Ihara
Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells.
The Journal of biological chemistry 2001;276(6):4454-60.
2001: Philipp J Kahle; Christian Haass
The emerging utility of animal models of chronic neurodegenerative diseases.
Expert opinion on therapeutic targets 2001;5(1):125-32.
2000: Masayasu Okochi; Stefan Eimer; A Bottcher; Ralf Baumeister; H Romig; Jochen Walter; Anja Capell; Harald Steiner; Christian Haass
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.
The Journal of biological chemistry 2000;275(52):40925-32.
2000: Harald Steiner; Christian Haass
Intramembrane proteolysis by presenilins.
Nature reviews. Molecular cell biology 2000;1(3):217-24.
2000: Oliver Wirths; S Weickert; K Majtenyi; L Havas; Philipp J Kahle; Masayasu Okochi; Christian Haass; Gerd Multhaup; Konrad Beyreuther; Thomas A Bayer
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.
Neuroreport 2000;11(17):3737-41.
2000: Philipp J Kahle; U Leimer; Christian Haass
Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
Trends in biochemical sciences 2000;25(11):524-7.
2000: Harald Steiner; Marcus Kostka; H Romig; G Basset; B Pesold; John Hardy; Anja Capell; Liane Meyn; M L Grim; Ralf Baumeister; K Fechteler; Christian Haass
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
Nature cell biology 2000;2(11):848-51.
2000: Anja Capell; Harald Steiner; Michael Willem; H Kaiser; C Meyer; Jochen Walter; Sven Lammich; Gerd Multhaup; Christian Haass
Maturation and pro-peptide cleavage of beta-secretase.
The Journal of biological chemistry 2000;275(40):30849-54.
2000: Paul Mathews; Anne M Cataldo; B H Kao; A G Rudnicki; X Qin; J L Yang; Ying Jiang; M Picciano; Christine M Hulette; Carol F Lippa; Thomas D Bird; David Nochlin; J Walter; Christian Haass; L Lévesque; Paul E Fraser; Athena Andreadis; Ralph A. Nixon
Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
Molecular medicine (Cambridge, Mass.) 2000;6(10):878-91.
2000: Philipp J Kahle; Manuela Neumann; Laurence Ozmen; V Muller; Helmut Jacobsen; A Schindzielorz; Masayasu Okochi; U Leimer; H van Der Putten; A Probst; Elisabeth Kremmer; Hans A Kretzschmar; Christian Haass
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6365-73.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.
The Journal of biological chemistry 2000;275(35):27348-53.
2000: J Walter; A Schindzielorz; B Hartung; Christian Haass
Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.
The Journal of biological chemistry 2000;275(31):23523-9.
2000: L Kulic; Jochen Walter; Gerd Multhaup; David B Teplow; Ralf Baumeister; H Romig; Anja Capell; Harald Steiner; Christian Haass
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5913-8.
2000: Anja Capell; Harald Steiner; H Romig; S Keck; Miriam Baader; MG Grim; Ralf Baumeister; Christian Haass
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch.
Nature cell biology 2000;2(4):205-11.
2000: Christian Haass; P J Kahle
Parkinson's pathology in a fly.
Nature 2000;404(6776):341, 343.
2000: Masayasu Okochi; Jochen Walter; A Koyama; S Nakajo; M Baba; Takeshi Iwatsubo; L Meijer; Philipp J Kahle; Christian Haass
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.
The Journal of biological chemistry 2000;275(1):390-7.
2000: H Hayashi; T Mizuno; Makoto Michikawa; Christian Haass; Katsuhiko Yanagisawa
Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains.
Biochimica et biophysica acta 2000;1483(1):81-90.
2000: Jochen Walter; Christian Haass
Posttranslational modifications of amyloid precursor protein : ectodomain phosphorylation and sulfation.
Methods in molecular medicine 2000;32():149-68.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.
Acta neurologica Scandinavica. Supplementum 2000;176():6-11.
2000: Philipp J Kahle; Manuela Neumann; Laurence Ozmen; Christian Haass
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.
Annals of the New York Academy of Sciences 2000;920():33-41.
2000: Christian Haass
Presenilin proteins and their function during embryonic development and Alzheimer's disease.
Ernst Schering Research Foundation workshop 2000;(29):57-64.
1999: Harald Steiner; B Pesold; Christian Haass
An in vivo assay for the identification of target proteases which cleave membrane-associated substrates.
FEBS letters 1999;463(3):245-9.
1999: Harald Steiner; H Romig; B Pesold; U Philipp; Miriam Baader; Martin Citron; Hansruedi Loetscher; Helmut Jacobsen; Christian Haass
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
Biochemistry 1999;38(44):14600-5.
1999: Daniele Sandmann-Keil; Heiko Braak; M Okochi; Christian Haass; Eva Braak
Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique.
Acta neuropathologica 1999;98(5):461-4.
1999: Christian Haass; Bart De Strooper
The presenilins in Alzheimer's disease--proteolysis holds the key.
Science (New York, N.Y.) 1999;286(5441):916-9.
1999: U Leimer; K Lun; H Romig; Jochen Walter; J Grünberg; M Brand; Christian Haass
Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
Biochemistry 1999;38(41):13602-9.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: Suzanne Y Guénette; J Chen; A Ferland; Christian Haass; A Capell; Rudolph E Tanzi
hFE65L influences amyloid precursor protein maturation and secretion.
Journal of neurochemistry 1999;73(3):985-93.
1999: Christian Haass; Eckhard Mandelkow
Proteolysis by presenilins and the renaissance of tau.
Trends in cell biology 1999;9(6):241-4.
1999: T Mizuno; M Nakata; H Naiki; Makoto Michikawa; Rong Wang; Christian Haass; Katsuhiko Yanagisawa
Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture.
The Journal of biological chemistry 1999;274(21):15110-4.
1999: Christian Haass
Apoptosis. Dead end for neurodegeneration?
Nature 1999;399(6733):204-5, 207.
1999: A Diehlmann; N Ida; Sascha Weggen; J Grünberg; Christian Haass; Colin L Masters; Thomas A Bayer; Konrad Beyreuther
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
Journal of neuroscience research 1999;56(4):405-19.
1999: S Lammich; Elzbieta Kojro; Rolf Postina; Sandra Gilbert; R Pfeiffer; M Jasionowski; Christian Haass; Falk Fahrenholz
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3922-7.
1999: Harald Steiner; H Romig; MG Grim; U Philipp; B Pesold; Martin Citron; Ralf Baumeister; Christian Haass
The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing.
The Journal of biological chemistry 1999;274(12):7615-8.
1999: Jochen Walter; A Schindzielorz; J Grünberg; Christian Haass
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1391-6.
1999: Harald Steiner; Anja Capell; Christian Haass
Proteolytic processing and degradation of Alzheimer's disease relevant proteins.
Biochemical Society transactions 1999;27(2):234-42.
1999: Dietmar R Thal; I Sassin; Christian Schultz; Christian Haass; Eva Braak; Heiko Braak
Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta.
Journal of neuropathology and experimental neurology 1999;58(2):210-6.
1999: Christian Haass; Ralf Baumeister
The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research.
European archives of psychiatry and clinical neuroscience 1999;249 Suppl 3():23-7.
1999: Harald Steiner; Anja Capell; U Leimer; Christian Haass
Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
European archives of psychiatry and clinical neuroscience 1999;249(6):266-70.
1999: Christian Haass
Biology of Alzheimer's disease.
European archives of psychiatry and clinical neuroscience 1999;249(6):265.
1998: Harald Steiner; Anja Capell; B Pesold; Martin Citron; P M Kloetzel; Dennis J Selkoe; H Romig; Klaus Mendla; Christian Haass
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
The Journal of biological chemistry 1998;273(48):32322-31.
1998: J Grünberg; Jochen Walter; Christopher B Eckman; Anja Capell; A Schindzielorz; Steven G Younkin; N Mehta; John Hardy; Christian Haass
Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40.
Neuroreport 1998;9(14):3293-9.
1998: T Mizuno; Christian Haass; Makoto Michikawa; Katsuhiko Yanagisawa
Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells.
Biochimica et biophysica acta 1998;1373(1):119-30.
1998: Fumitaka Oyama; N Sawamura; K Kobayashi; Maho Morishima-Kawashima; T Kuramochi; Mie Ito; Taisuke Tomita; Kei Maruyama; Takaomi C Saido; Takeshi Iwatsubo; Anja Capell; Jochen Walter; J Grünberg; Yoshito Ueyama; Christian Haass; Yasuo Ihara
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: Manfred Brockhaus; J Grünberg; S Röhrig; Hansruedi Loetscher; N Wittenburg; Ralf Baumeister; Helmut Jacobsen; Christian Haass
Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.
Neuroreport 1998;9(7):1481-6.
1998: Jochen Walter; J Grünberg; A Schindzielorz; Christian Haass
Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
Biochemistry 1998;37(17):5961-7.
1998: J Grunberg; Jochen Walter; Hansruedi Loetscher; Ulrich Deuschle; Helmut Jacobsen; Christian Haass
Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
Biochemistry 1998;37(8):2263-70.
1998: Anja Capell; J Grünberg; B Pesold; A Diehlmann; Martin Citron; Ralph A. Nixon; Konrad Beyreuther; Dennis J Selkoe; Christian Haass
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Christian Haass; Dennis J Selkoe
Alzheimer's disease. A technical KO of amyloid-beta peptide.
Nature 1998;391(6665):339-40.
1998: Christian Haass; Ralf Baumeister
What do we learn from a few familial Alzheimer's disease cases?
Journal of neural transmission. Supplementum 1998;54():137-45.
1998: Christian Haass; J Grünberg; Anja Capell; Christine Wild-Bode; U Leimer; Jochen Walter; T Yamazaki; I Ihara; I Zweckbronner; C Jakubek; Ralf Baumeister
Proteolytic processing of Alzheimer's disease associated proteins.
Journal of neural transmission. Supplementum 1998;53():159-67.
1997: Anja Capell; Rainer Saffrich; JC Olivo; Liane Meyn; Jochen Walter; J Grünberg; Paul Mathews; Ralph A. Nixon; Carlos G Dotti; Christian Haass
Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.
Journal of neurochemistry 1997;69(6):2432-40.
1997: S H Kim; Y K Kim; S J Jeong; Christian Haass; Yung-Hi Kim; Yoo-Hun Suh
Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine.
Molecular pharmacology 1997;52(3):430-6.
1997: Hansruedi Loetscher; Ulrich Deuschle; Manfred Brockhaus; D Reinhardt; Peter Nelboeck; Jan Mous; J Grünberg; Christian Haass; Helmut Jacobsen
Presenilins are processed by caspase-type proteases.
The Journal of biological chemistry 1997;272(33):20655-9.
1997: T Yamazaki; Christian Haass; Takaomi C Saido; S Omura; Yasuo Ihara
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Biochemistry 1997;36(27):8377-83.
1997: Christine Wild-Bode; T Yamazaki; Anja Capell; U Leimer; Harald Steiner; Yasuo Ihara; Christian Haass
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
The Journal of biological chemistry 1997;272(26):16085-8.
1997: Jochen Walter; J Grünberg; Anja Capell; B Pesold; A Schindzielorz; Martin Citron; Klaus Mendla; Peter St George-Hyslop; Gerd Multhaup; Dennis J Selkoe; Christian Haass
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: Christian Haass
Presenilins: genes for life and death.
Neuron 1997;18(5):687-90.
1997: Ralf Baumeister; U Leimer; I Zweckbronner; C Jakubek; J Grünberg; Christian Haass
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
Genes and function 1997;1(2):149-59.
1997: Weiming Xia; Jimin Zhang; Dora Kholodenko; Martin Citron; Marcia B Podlisny; David B Teplow; Christian Haass; Peter Seubert; Edward H Koo; Dennis J Selkoe
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
The Journal of biological chemistry 1997;272(12):7977-82.
1997: Taisuke Tomita; Kei Maruyama; Takaomi C Saido; H Kume; K Shinozaki; S Tokuhiro; Anja Capell; Jochen Walter; J Grünberg; Christian Haass; Takeshi Iwatsubo; Kunihiko Obata
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1997: Jochen Walter; Anja Capell; A Y Hung; H Langen; M Schnölzer; Gopal Thinakaran; Sangram S Sisodia; Dennis J Selkoe; Christian Haass
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry 1997;272(3):1896-903.
1997: Marcia B Podlisny; Martin Citron; P Amarante; R Sherrington; Weiming Xia; Jimin Zhang; Thekla S Diehl; Georges Levesque; Paul E Fraser; Christian Haass; Edward H Koo; Peter Seubert; Peter St George-Hyslop; David B Teplow; Dennis J Selkoe
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Neurobiology of disease 1997;3(4):325-37.
1996: Jochen Walter; Anja Capell; J Grünberg; B Pesold; A Schindzielorz; R Prior; Marcia B Podlisny; Paul E Fraser; Peter St George-Hyslop; Dennis J Selkoe; Christian Haass
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Molecular medicine (Cambridge, Mass.) 1996;2(6):673-91.
1996: Christian Haass
Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease.
Current opinion in neurology 1996;9(4):254-9.
1996: Martin Citron; Thekla S Diehl; Anja Capell; Christian Haass; David B Teplow; Dennis J Selkoe
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
Neuron 1996;17(1):171-9.
1996: Wei Qiao Qiu; W Borth; Z Ye; Christian Haass; David B Teplow; Dennis J Selkoe
Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.
The Journal of biological chemistry 1996;271(14):8443-51.
1996: Dennis J Selkoe; T Yamazaki; Martin Citron; Marcia B Podlisny; Edward H Koo; David B Teplow; Christian Haass
The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.
Annals of the New York Academy of Sciences 1996;777():57-64.
1996: Christian Haass
The molecular significance of amyloid beta-peptide for Alzheimer's disease.
European archives of psychiatry and clinical neuroscience 1996;246(3):118-23.
1995: Christian Haass; Cynthia A Lemere; Anja Capell; Martin Citron; Peter Seubert; Dale Schenk; Lars Lannfelt; Dennis J Selkoe
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine 1995;1(12):1291-6.
1995: J S Munger; Christian Haass; Cynthia A Lemere; Guo-Ping Shi; W S Wong; David B Teplow; Dennis J Selkoe; Harold A Chapman
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
The Biochemical journal 1995;311 ( Pt 1)():299-305.
1995: Cynthia A Lemere; J S Munger; Guo-Ping Shi; L Natkin; Christian Haass; Harold A Chapman; Dennis J Selkoe
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
The American journal of pathology 1995;146(4):848-60.
1995: Christian Haass; Anja Capell; Martin Citron; David B Teplow; Dennis J Selkoe
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
The Journal of biological chemistry 1995;270(11):6186-92.
1995: Christian Haass; Edward H Koo; Anja Capell; David B Teplow; Dennis J Selkoe
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
The Journal of cell biology 1995;128(4):537-47.
1994: Amy Lo; Christian Haass; S L Wagner; David B Teplow; Sangram S Sisodia
Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1994;269(49):30966-73.
1994: Christian Haass; A Y Hung; Dennis J Selkoe; David B Teplow
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
The Journal of biological chemistry 1994;269(26):17741-8.
1994: Christian Haass; Edward H Koo; David B Teplow; Dennis J Selkoe
Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1564-8.
1993: Christian Haass; Dennis J Selkoe
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.
Cell 1993;75(6):1039-42.
1993: A Y Hung; Christian Haass; Roger M Nitsch; Wei Qiao Qiu; Martin Citron; Richard Jay Wurtman; John H Growdon; Dennis J Selkoe
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
The Journal of biological chemistry 1993;268(31):22959-62.
1993: Martin Citron; Christian Haass; Dennis J Selkoe
Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596.
Neurobiology of aging 1993;14(6):571-3.
1993: Christian Haass; A Y Hung; Michael G Schlossmacher; Tilman Oltersdorf; David B Teplow; Dennis J Selkoe
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Annals of the New York Academy of Sciences 1993;695():109-16.
1993: Christian Haass; A Y Hung; Michael G Schlossmacher; David B Teplow; Dennis J Selkoe
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
The Journal of biological chemistry 1993;268(5):3021-4.
1992: Martin Citron; Tilman Oltersdorf; Christian Haass; Lisa McConlogue; A Y Hung; Peter Seubert; C Vigo-Pelfrey; I Lieberburg; Dennis J Selkoe
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature 1992;360(6405):672-4.
1992: A Y Hung; Edward H Koo; Christian Haass; Dennis J Selkoe
Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9439-43.
1992: Christian Haass; Michael G Schlossmacher; A Y Hung; C Vigo-Pelfrey; A Mellon; Beth L Ostaszewski; I Lieberburg; Edward H Koo; Dale Schenk; David B Teplow
Amyloid beta-peptide is produced by cultured cells during normal metabolism.
Nature 1992;359(6393):322-5.
1992: Christian Haass; Edward H Koo; A Mellon; A Y Hung; Dennis J Selkoe
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
Nature 1992;357(6378):500-3.
1992: Michael G Schlossmacher; Beth L Ostaszewski; L I Hecker; A Celi; Christian Haass; D Chin; I Lieberburg; B C Furie; B Furie; Dennis J Selkoe
Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
Neurobiology of aging 1992;13(3):421-34.
1992: S Frentzel; M Troxell; Christian Haass; B Pesold-Hurt; K H Glätzer; Peter-M Kloetzel
Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35.
European journal of biochemistry / FEBS 1992;205(3):1043-51.
1991: Christian Haass; A Y Hung; Dennis J Selkoe
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(12):3783-93.
1991: Peter-M Kloetzel; S Frentzel; M Gernold; Christian Haass; U Klein; B Pesold-Hurt; Anna Seelig
The proteasome of Drosophila and features of the evolutionarily conserved PROS-gene family.
Biomedica biochimica acta 1991;50(4-6):451-7.
1990: Christian Haass; B Pesold-Hurt; Peter-M Kloetzel
The Drosophila PROS-29 gene is a new member of the PROS-gene family.
Nucleic acids research 1990;18(13):4018.
1990: Christian Haass; U Klein; P M Kloetzel
Developmental expression of Drosophila melanogaster small heat-shock proteins.
Journal of cell science 1990;96 ( Pt 3)():413-8.
1990: Christian Haass; B Pesold-Hurt; Gerd Multhaup; Konrad Beyreuther; Peter-M Kloetzel
The Drosophila PROS-28.1 gene is a member of the proteasome gene family.
Gene 1990;90(2):235-41.
1990: Christian Haass; P M Kloetzel
Molecular analysis of alpha ecdysone induced 16S complexes in Drosophila Schneider's S3 cells.
Biochemical and biophysical research communications 1990;168(1):314-9.
1989: Christian Haass; B Pesold-Hurt; Gerd Multhaup; Konrad Beyreuther; Peter-M Kloetzel
The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.
The EMBO journal 1989;8(8):2373-9.
1989: Christian Haass; Peter-M Kloetzel
The Drosophila proteasome undergoes changes in its subunit pattern during development.
Experimental cell research 1989;180(1):243-52.
1988: P E Falkenburg; Christian Haass; Peter-M Kloetzel; B Niedel; Friedrich Kopp; L Kuehn; Burkhardt Dahlmann
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase.
Nature 1988;331(6152):190-2.