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Christian Haass

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Disorders

Alzheimer Disease

Anatomy

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Physiology

Living Beings

Mice

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Co-Publications
Name
47
Steiner, Harald
37
Capell, Anja
29
Selkoe, Dennis
24
Walter, Jochen
23
Kahle, Philipp
20
Teplow, David
16
Kaether, Christoph
16
Citron, Martin
15
Grünberg, J
14
Edbauer, Dieter
14
Fluhrer, Regina
14
Baumeister, Ralf
11
Kretzschmar, Hans
11
Multhaup, Gerd
11
Neumann, Manuela

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Publications

TOP 3
Bittner Tobias; Fuhrmann Martin; Burgold Steffen; Jung Christian K E; Volbracht Christiane; Steiner Harald; Mitteregger Gerda; Kretzschmar Hans A; Haass Christian; Herms Jochen
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.
Dormann Dorothee; Capell Anja; Carlson Aaron M; Shankaran Sunita S; Rodde Ramona; Neumann Manuela; Kremmer Elisabeth; Matsuwaki Takashi; Yamanouchi Keitaro; Nishihara Masugi; Haass Christian
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Fluhrer Regina; Steiner Harald; Haass Christian
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.

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All Publications

2009: Bittner Tobias; Fuhrmann Martin; Burgold Steffen; Jung Christian K E; Volbracht Christiane; Steiner Harald; Mitteregger Gerda; Kretzschmar Hans A; Haass Christian; Herms Jochen
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(33):10405-9.
2009: Dormann Dorothee; Capell Anja; Carlson Aaron M; Shankaran Sunita S; Rodde Ramona; Neumann Manuela; Kremmer Elisabeth; Matsuwaki Takashi; Yamanouchi Keitaro; Nishihara Masugi; Haass Christian
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry 2009;110(3):1082-94.
2009: Fluhrer Regina; Steiner Harald; Haass Christian
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.
The Journal of biological chemistry 2009;284(21):13975-9.
2009: Winkler Edith; Hobson Scott; Fukumori Akio; Dümpelfeld Birgit; Luebbers Thomas; Baumann Karlheinz; Haass Christian; Hopf Carsten; Steiner Harald
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Biochemistry 2009;48(6):1183-97.
2009: Martin Lucas; Fluhrer Regina; Haass Christian
Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis.
The Journal of biological chemistry 2009;284(9):5662-70.
2008: O'Connor Tracy; Sadleir Katherine R; Maus Erika; Velliquette Rodney A; Zhao Jie; Cole Sarah L; Eimer William A; Hitt Brian; Bembinster Leslie A; Lammich Sven; Lichtenthaler Stefan F; Hébert Sébastien S; De Strooper Bart; Haass Christian; Bennett David A; Vassar Robert
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron 2008;60(6):988-1009.
2008: Steiner Harald; Winkler Edith; Haass Christian
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
The Journal of biological chemistry 2008;283(50):34677-86.
2008: Fluhrer Regina; Fukumori Akio; Martin Lucas; Grammer Gudula; Haug-Kröper Martina; Klier Bärbel; Winkler Edith; Kremmer Elisabeth; Condron Margaret M; Teplow David B; Steiner Harald; Haass Christian
Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.
The Journal of biological chemistry 2008;283(44):30121-8.
2008: Steiner Harald; Fluhrer Regina; Haass Christian
Intramembrane proteolysis by gamma-secretase.
The Journal of biological chemistry 2008;283(44):29627-31.
2008: Busche Marc Aurel; Eichhoff Gerhard; Adelsberger Helmuth; Abramowski Dorothee; Wiederhold Karl-Heinz; Haass Christian; Staufenbiel Matthias; Konnerth Arthur; Garaschuk Olga
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.
Science (New York, N.Y.) 2008;321(5896):1686-9.
2008: Dejaegere T; Serneels L; Schäfer M K; Van Biervliet J; Horré K; Depboylu C; Alvarez-Fischer D; Herreman A; Willem M; Haass C; Höglinger G U; D'Hooge R; De Strooper B
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9775-80.
2008: St George-Hyslop Peter; Haass Christian
Regulatory RNA goes awry in Alzheimer's disease.
Nature medicine 2008;14(7):711-2.
2008: Schöbel Susanne; Neumann Stephanie; Hertweck Maren; Dislich Bastian; Kuhn Peer-Hendrik; Kremmer Elisabeth; Seed Brian; Baumeister Ralf; Haass Christian; Lichtenthaler Stefan F
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
The Journal of biological chemistry 2008;283(21):14257-68.
2008: Winklhofer Konstanze F; Tatzelt Jörg; Haass Christian
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.
The EMBO journal 2008;27(2):336-49.
2008: Shankaran Sunita S; Capell Anja; Hruscha Alexander T; Fellerer Katrin; Neumann Manuela; Schmid Bettina; Haass Christian
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry 2008;283(3):1744-53.
2008: Martin Lucas; Fluhrer Regina; Reiss Karina; Kremmer Elisabeth; Saftig Paul; Haass Christian
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
The Journal of biological chemistry 2008;283(3):1644-52.
2008: Page Richard M; Baumann Karlheinz; Tomioka Masanori; Pérez-Revuelta Blanca I; Fukumori Akio; Jacobsen Helmut; Flohr Alexander; Luebbers Thomas; Ozmen Laurence; Steiner Harald; Haass Christian
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
The Journal of biological chemistry 2008;283(2):677-83.
2007: Exner Nicole; Treske Bettina; Paquet Dominik; Holmström Kira; Schiesling Carola; Gispert Suzana; Carballo-Carbajal Iria; Berg Daniela; Hoepken Hans-Hermann; Gasser Thomas; Krüger Rejko; Winklhofer Konstanze F; Vogel Frank; Reichert Andreas S; Auburger Georg; Kahle Philipp J; Schmid Bettina; Haass Christian
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(45):12413-8.
2007: Sato Toru; Diehl Thekla S; Narayanan Saravanakumar; Funamoto Satoru; Ihara Yasuo; De Strooper Bart; Steiner Harald; Haass Christian; Wolfe Michael S
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry 2007;282(47):33985-93.
2007: Freichel Christian; Neumann Manuela; Ballard Theresa; Müller Veronika; Woolley Marie; Ozmen Laurence; Borroni Edilio; Kretzschmar Hans A; Haass Christian; Spooren Will; Kahle Philipp J
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.
Neurobiology of aging 2007;28(9):1421-35.
2007: Hamid Runa; Kilger Ellen; Willem Michael; Vassallo Neville; Kostka Markus; Bornhövd Carsten; Reichert Andreas S; Kretzschmar Hans A; Haass Christian; Herms Jochen
Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.
Journal of neurochemistry 2007;102(4):1264-75.
2007: Kaether Christoph; Scheuermann Johanna; Fassler Matthias; Zilow Sonja; Shirotani Keiro; Valkova Christina; Novak Bozidar; Kacmar Slavomir; Steiner Harald; Haass Christian
Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.
EMBO reports 2007;8(8):743-8.
2007: Thal Dietmar Rudolf; Larionov Sergey; Abramowski Dorothee; Wiederhold Karl-Heinz; Van Dooren Tom; Yamaguchi Haruyasu; Haass Christian; Van Leuven Fred; Staufenbiel Matthias; Capetillo-Zarate Estibaliz
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging 2007;28(8):1221-30.
2007: Shirotani Keiro; Tomioka Masanori; Kremmer Elisabeth; Haass Christian; Steiner Harald
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Neurobiology of disease 2007;27(1):102-7.
2007: Prager Kai; Wang-Eckhardt Lihua; Fluhrer Regina; Killick Richard; Barth Esther; Hampel Heike; Haass Christian; Walter Jochen
A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling.
The Journal of biological chemistry 2007;282(19):14083-93.
2007: Görner Karin; Holtorf Eve; Waak Jens; Pham Thu-Trang; Vogt-Weisenhorn Daniela M; Wurst Wolfgang; Haass Christian; Kahle Philipp J
Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1.
The Journal of biological chemistry 2007;282(18):13680-91.
2007: Kuhn Peer-Hendrik; Marjaux Els; Imhof Axel; De Strooper Bart; Haass Christian; Lichtenthaler Stefan F
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.
The Journal of biological chemistry 2007;282(16):11982-95.
2007: Haffner Christof; Dettmer Ulf; Weiler Timotheus; Haass Christian
The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex.
The Journal of biological chemistry 2007;282(14):10632-8.
2007: Schiffer Niclas W; Broadley Sarah A; Hirschberger Thomas; Tavan Paul; Kretzschmar Hans A; Giese Armin; Haass Christian; Hartl F Ulrich; Schmid Bettina
Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model.
The Journal of biological chemistry 2007;282(12):9195-203.
2007: Haass Christian; Selkoe Dennis J
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Nature reviews. Molecular cell biology 2007;8(2):101-12.
2007: Narlawar Rajeshwar; Pérez Revuelta Blanca I; Baumann Karlheinz; Schubenel Robert; Haass Christian; Steiner Harald; Schmidt Boris
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.
Bioorganic & medicinal chemistry letters 2007;17(1):176-82.
2007: Fluhrer Regina; Haass Christian
Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
Neuro-degenerative diseases 2007;4(2-3):112-6.
2006: Narlawar Rajeshwar; Pérez Revuelta Blanca I; Haass Christian; Steiner Harald; Schmidt Boris; Baumann Karlheinz
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
Journal of medicinal chemistry 2006;49(26):7588-91.
2006: Capetillo-Zarate Estibaliz; Staufenbiel Matthias; Abramowski Dorothee; Haass Christian; Escher Angelika; Stadelmann Christine; Yamaguchi Haruyasu; Wiestler Otmar D; Thal Dietmar Rudolf
Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.
Brain : a journal of neurology 2006;129(Pt 11):2992-3005.
2006: Willem Michael; Garratt Alistair N; Novak Bozidar; Citron Martin; Kaufmann Steve; Rittger Andrea; DeStrooper Bart; Saftig Paul; Birchmeier Carmen; Haass Christian
Control of peripheral nerve myelination by the beta-secretase BACE1.
Science (New York, N.Y.) 2006;314(5799):664-6.
2006: Radde Rebecca; Bolmont Tristan; Kaeser Stephan A; Coomaraswamy Janaky; Lindau Dennis; Stoltze Lars; Calhoun Michael E; Jäggi Fabienne; Wolburg Hartwig; Gengler Simon; Haass Christian; Ghetti Bernardino; Czech Christian; Hölscher Christian; Mathews Paul M; Jucker Mathias
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.
EMBO reports 2006;7(9):940-6.
2006: Steiner Harald; Than Manuel; Bode Wolfram; Haass Christian
Pore-forming scissors? A first structural glimpse of gamma-secretase.
Trends in biochemical sciences 2006;31(9):491-3.
2006: Fluhrer Regina; Grammer Gudula; Israel Lars; Condron Margaret M; Haffner Christof; Friedmann Elena; Böhland Claudia; Imhof Axel; Martoglio Bruno; Teplow David B; Haass Christian
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.
Nature cell biology 2006;8(8):894-6.
2006: Wild-Bode Christine; Fellerer Katrin; Kugler Johanna; Haass Christian; Capell Anja
A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.
The Journal of biological chemistry 2006;281(33):23824-9.
2006: Avila Jesús; Nitsch Roger M; Haass Christian; De Strooper Bart
European Alzheimer disease funding.
Nature medicine 2006;12(7):776-7.
2006: Goldsbury Claire; Mocanu Maria-Magdalena; Thies Edda; Kaether Christoph; Haass Christian; Keller Patrick; Biernat Jacek; Mandelkow Eckhard; Mandelkow Eva-Maria
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.
Traffic (Copenhagen, Denmark) 2006;7(7):873-88.
2006: Anders Lars; Mertins Philipp; Lammich Sven; Murgia Marta; Hartmann Dieter; Saftig Paul; Haass Christian; Ullrich Axel
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Molecular and cellular biology 2006;26(10):3917-34.
2006: Böhm Christopher; Seibel Nicole M; Henkel Birgit; Steiner Harald; Haass Christian; Hampe Wolfgang
SorLA signaling by regulated intramembrane proteolysis.
The Journal of biological chemistry 2006;281(21):14547-53.
2006: Fukumori Akio; Okochi Masayasu; Tagami Shinji; Jiang Jingwei; Itoh Naohiro; Nakayama Taisuke; Yanagida Kanta; Ishizuka-Katsura Yoshiko; Morihara Takashi; Kamino Kojin; Tanaka Toshihisa; Kudo Takashi; Tanii Hisashi; Ikuta Akiko; Haass Christian; Takeda Masatoshi
Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.
Biochemistry 2006;45(15):4907-14.
2006: Yamasaki Aya; Eimer Stefan; Okochi Masayasu; Smialowska Agata; Kaether Christoph; Baumeister Ralf; Haass Christian; Steiner Harald
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3821-8.
2006: Kaether Christoph; Schmitt Stephanie; Willem Michael; Haass Christian
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
Traffic (Copenhagen, Denmark) 2006;7(4):408-15.
2006: Okochi Masayasu; Fukumori Akio; Jiang Jingwei; Itoh Naohiro; Kimura Ryo; Steiner Harald; Haass Christian; Tagami Shinji; Takeda Masatoshi
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
The Journal of biological chemistry 2006;281(12):7890-8.
2006: Neumann Stephanie; Schöbel Susanne; Jäger Sebastian; Trautwein Anna; Haass Christian; Pietrzik Claus U; Lichtenthaler Stefan F
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.
The Journal of biological chemistry 2006;281(11):7583-94.
2006: Haffner Christof; Haass Christian
Cellular functions of gamma-secretase-related proteins.
Neuro-degenerative diseases 2006;3(4-5):284-9.
2006: Kaether Christoph; Haass Christian; Steiner Harald
Assembly, trafficking and function of gamma-secretase.
Neuro-degenerative diseases 2006;3(4-5):275-83.
2005: Thal Dietmar Rudolf; Capetillo-Zarate Estibaliz; Schultz Christian; Rüb Udo; Saido Takaomi C; Yamaguchi Haruyasu; Haass Christian; Griffin W Sue T; Del Tredici Kelly; Braak Heiko; Ghebremedhin Estifanos
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Acta neuropathologica 2005;110(5):459-71.
2005: Straub Tobias; Neumann Martin F; Prestel Matthias; Kremmer Elisabeth; Kaether Christoph; Haass Christian; Becker Peter B
Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment.
Chromosoma 2005;114(5):352-64.
2005: Krawitz Peter; Haffner Christof; Fluhrer Regina; Steiner Harald; Schmid Bettina; Haass Christian
Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.
The Journal of biological chemistry 2005;280(47):39515-23.
2005: Giese Armin; Bader Benedikt; Bieschke Jan; Schaffar Gregor; Odoy Sabine; Kahle Philipp J; Haass Christian; Kretzschmar Hans
Single particle detection and characterization of synuclein co-aggregation.
Biochemical and biophysical research communications 2005;333(4):1202-10.
2005: Prokop Stefan; Haass Christian; Steiner Harald
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Journal of neurochemistry 2005;94(1):57-62.
2005: Wahle Tina; Prager Kai; Raffler Nikolai; Haass Christian; Famulok Michael; Walter Jochen
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.
Molecular and cellular neurosciences 2005;29(3):453-61.
2005: Andersson Christian X; Fernandez-Rodriguez Julia; Laos Sirle; Baeckström Dan; Haass Christian; Hansson Gunnar C
Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.
The Biochemical journal 2005;387(Pt 2):377-84.
2005: Stefanova Nadia; Reindl Markus; Neumann Manuela; Haass Christian; Poewe Werner; Kahle Philipp J; Wenning Gregor K
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.
The American journal of pathology 2005;166(3):869-76.
2005: Uelhoff Armgard; Tatzelt Jörg; Aguzzi Adriano; Winklhofer Konstanze F; Haass Christian
A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.
The Journal of biological chemistry 2005;280(7):5137-40.
2005: Capell Anja; Beher Dirk; Prokop Stefan; Steiner Harald; Kaether Christoph; Shearman Mark S; Haass Christian
Gamma-secretase complex assembly within the early secretory pathway.
The Journal of biological chemistry 2005;280(8):6471-8.
2005: Yamamoto Ayako; Friedlein Arno; Imai Yuzuru; Takahashi Ryosuke; Kahle Philipp J; Haass Christian
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.
The Journal of biological chemistry 2005;280(5):3390-9.
2004: Neumann Manuela; Müller Veronika; Kretzschmar Hans A; Haass Christian; Kahle Philipp J
Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.
Journal of neuropathology and experimental neurology 2004;63(12):1225-35.
2004: Kaether Christoph; Haass Christian
A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation.
The Journal of cell biology 2004;167(5):809-12.
2004: Kaether Christoph; Capell Anja; Edbauer Dieter; Winkler Edith; Novak Bozidar; Steiner Harald; Haass Christian
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
The EMBO journal 2004;23(24):4738-48.
2004: Westmeyer Gil G; Willem Michael; Lichtenthaler Stefan F; Lurman Glenn; Multhaup Gerd; Assfalg-Machleidt Irmgard; Reiss Karina; Saftig Paul; Haass Christian
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
The Journal of biological chemistry 2004;279(51):53205-12.
2004: Willem Michael; Dewachter Ilse; Smyth Neil; Van Dooren Tom; Borghgraef Peter; Haass Christian; Van Leuven Fred
beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice.
The American journal of pathology 2004;165(5):1621-31.
2004: Keil Uta; Bonert Astrid; Marques Celio A; Scherping Isabel; Weyermann Jörg; Strosznajder Joanna B; Müller-Spahn Franz; Haass Christian; Czech Christian; Pradier Laurent; Müller Walter E; Eckert Anne
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis.
The Journal of biological chemistry 2004;279(48):50310-20.
2004: Shirotani Keiro; Edbauer Dieter; Prokop Stefan; Haass Christian; Steiner Harald
Identification of distinct gamma-secretase complexes with different APH-1 variants.
The Journal of biological chemistry 2004;279(40):41340-5.
2004: Schmechel Ariane; Strauss Markus; Schlicksupp Andrea; Pipkorn Rüdiger; Haass Christian; Bayer Thomas A; Multhaup Gerd
Human BACE forms dimers and colocalizes with APP.
The Journal of biological chemistry 2004;279(38):39710-7.
2004: Edbauer Dieter; Kaether Christoph; Steiner Harald; Haass Christian
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
The Journal of biological chemistry 2004;279(36):37311-5.
2004: Haffner Christof; Frauli Mélanie; Topp Stephanie; Irmler Martin; Hofmann Kay; Regula Jörg T; Bally-Cuif Laure; Haass Christian
Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.
The EMBO journal 2004;23(15):3041-50.
2004: Kahle Philipp J; Haass Christian
How does parkin ligate ubiquitin to Parkinson's disease?
EMBO reports 2004;5(7):681-5.
2004: Shirotani Keiro; Edbauer Dieter; Kostka Marcus; Steiner Harald; Haass Christian
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Journal of neurochemistry 2004;89(6):1520-7.
2004: Lammich Sven; Schöbel Susanne; Zimmer Ann-Katrin; Lichtenthaler Stefan F; Haass Christian
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.
EMBO reports 2004;5(6):620-5.
2004: Neumann Manuela; Müller Veronika; Görner Karin; Kretzschmar Hans A; Haass Christian; Kahle Philipp J
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.
Acta neuropathologica 2004;107(6):489-96.
2004: Lichtenthaler Stefan F; Haass Christian
Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model.
The Journal of clinical investigation 2004;113(10):1384-7.
2004: Prokop Stefan; Shirotani Keiro; Edbauer Dieter; Haass Christian; Steiner Harald
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.
The Journal of biological chemistry 2004;279(22):23255-61.
2004: Nuscher Brigitte; Kamp Frits; Mehnert Thomas; Odoy Sabine; Haass Christian; Kahle Philipp J; Beyer Klaus
Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.
The Journal of biological chemistry 2004;279(21):21966-75.
2004: Haass Christian
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.
The EMBO journal 2004;23(3):483-8.
2004: Görner Karin; Holtorf Eve; Odoy Sabine; Nuscher Brigitte; Yamamoto Ayako; Regula Jörg T; Beyer Klaus; Haass Christian; Kahle Philipp J
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.
The Journal of biological chemistry 2004;279(8):6943-51.
2004: Fluhrer Regina; Friedlein Arno; Haass Christian; Walter Jochen
Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.
The Journal of biological chemistry 2004;279(3):1585-93.
2004: Haffner Christof; Haass Christian
The biochemical and genetic odyssey to the function of a nicastrin-like protein.
Neuro-degenerative diseases 2004;1(4-5):192-5.
2003: Capell Anja; Kaether Christoph; Edbauer Dieter; Shirotani Keiro; Merkl Sabine; Steiner Harald; Haass Christian
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.
The Journal of biological chemistry 2003;278(52):52519-23.
2003: Lichtenthaler Stefan F; Dominguez Diana-Ines; Westmeyer Gil G; Reiss Karina; Haass Christian; Saftig Paul; De Strooper Bart; Seed Brian
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
The Journal of biological chemistry 2003;278(49):48713-9.
2003: Aguzzi Adriano; Haass Christian
Games played by rogue proteins in prion disorders and Alzheimer's disease.
Science (New York, N.Y.) 2003;302(5646):814-8.
2003: Marques Celio A; Keil Uta; Bonert Astrid; Steiner Barbara; Haass Christian; Muller Walter E; Eckert Anne
Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.
The Journal of biological chemistry 2003;278(30):28294-302.
2003: Sato Toru; Dohmae Naoshi; Qi Yue; Kakuda Nobuto; Misonou Hiroaki; Mitsumori Rie; Maruyama Hiroko; Koo Edward H; Haass Christian; Takio Koji; Morishima-Kawashima Maho; Ishiura Shoichi; Ihara Yasuo
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(27):24294-301.
2003: Edbauer Dieter; Winkler Edith; Regula Joerg T; Pesold Brigitte; Steiner Harald; Haass Christian
Reconstitution of gamma-secretase activity.
Nature cell biology 2003;5(5):486-8.
2003: Shirotani Keiro; Edbauer Dieter; Capell Anja; Schmitz Julia; Steiner Harald; Haass Christian
Gamma-secretase activity is associated with a conformational change of nicastrin.
The Journal of biological chemistry 2003;278(19):16474-7.
2003: Fluhrer Regina; Multhaup Gerd; Schlicksupp Andrea; Okochi Masayasu; Takeda Masatoshi; Lammich Sven; Willem Michael; Westmeyer Gil; Bode Wolfram; Walter Jochen; Haass Christian
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
The Journal of biological chemistry 2003;278(8):5531-8.
2003: Ehehalt Robert; Keller Patrick; Haass Christian; Thiele Christoph; Simons Kai
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts.
The Journal of cell biology 2003;160(1):113-23.
2002: Haass Christian; Steiner Harald
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
Trends in cell biology 2002;12(12):556-62.
2002: Neumann Manuela; Kahle Philipp J; Giasson Benoit I; Ozmen Laurence; Borroni Edilio; Spooren Will; Müller Veronika; Odoy Sabine; Fujiwara Hideo; Hasegawa Masato; Iwatsubo Takeshi; Trojanowski John Q; Kretzschmar Hans A; Haass Christian
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
The Journal of clinical investigation 2002;110(10):1429-39.
2002: Haass Christian
New hope for Alzheimer disease vaccine.
Nature medicine 2002;8(11):1195-6.
2002: Lammich Sven; Okochi Masayasu; Takeda Masatoshi; Kaether Christoph; Capell Anja; Zimmer Ann-Katrin; Edbauer Dieter; Walter Jochen; Steiner Harald; Haass Christian
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
The Journal of biological chemistry 2002;277(47):44754-9.
2002: Okochi Masayasu; Steiner Harald; Fukumori Akio; Tanii Hisashi; Tomita Taisuke; Tanaka Toshihisa; Iwatsubo Takeshi; Kudo Takashi; Takeda Masatoshi; Haass Christian
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
The EMBO journal 2002;21(20):5408-16.
2002: Steiner Harald; Winkler Edith; Edbauer Dieter; Prokop Stefan; Basset Gabriele; Yamasaki Aya; Kostka Marcus; Haass Christian
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
The Journal of biological chemistry 2002;277(42):39062-5.
2002: Kahle Philipp J; Haass Christian; Kretzschmar Hans A; Neumann Manuela
Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases.
Journal of neurochemistry 2002;82(3):449-57.
2002: Kaether Christoph; Lammich Sven; Edbauer Dieter; Ertl Michaela; Rietdorf Jens; Capell Anja; Steiner Harald; Haass Christian
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
The Journal of cell biology 2002;158(3):551-61.
2002: Geling Andrea; Steiner Harald; Willem Michael; Bally-Cuif Laure; Haass Christian
A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.
EMBO reports 2002;3(7):688-94.
2002: Fluhrer Regina; Capell Anja; Westmeyer Gil; Willem Michael; Hartung Bianka; Condron Margaret M; Teplow David B; Haass Christian; Walter Jochen
A non-amyloidogenic function of BACE-2 in the secretory pathway.
Journal of neurochemistry 2002;81(5):1011-20.
2002: Leutz Steffen; Steiner Barbara; Marques Celio A; Haass Christian; Müller Walter E; Eckert Anne
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death.
Journal of molecular neuroscience : MN 2002;18(3):189-201.
2002: Edbauer Dieter; Winkler Edith; Haass Christian; Steiner Harald
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8666-71.
2002: Moehlmann Tobias; Winkler Edith; Xia Xuefeng; Edbauer Dieter; Murrell Jill; Capell Anja; Kaether Christoph; Zheng Hui; Ghetti Bernardino; Haass Christian; Steiner Harald
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8025-30.
2002: Kahle Philipp J; Neumann Manuela; Ozmen Laurence; Muller Veronika; Jacobsen Helmut; Spooren Will; Fuss Babette; Mallon Barbara; Macklin Wendy B; Fujiwara Hideo; Hasegawa Masato; Iwatsubo Takeshi; Kretzschmar Hans A; Haass Christian
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
EMBO reports 2002;3(6):583-8.
2002: Edbauer Dieter; Willem Michael; Lammich Sven; Steiner Harald; Haass Christian
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).
The Journal of biological chemistry 2002;277(16):13389-93.
2002: Capell Anja; Meyn Liane; Fluhrer Regina; Teplow David B; Walter Jochen; Haass Christian
Apical sorting of beta-secretase limits amyloid beta-peptide production.
The Journal of biological chemistry 2002;277(7):5637-43.
2002: Thal D R; Ghebremedhin E; Haass C; Schultz C
UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain.
Clinical neuropathology 2002;21(1):35-40.
2001: Kahle P J; Neumann M; Ozmen L; Müller V; Odoy S; Okamoto N; Jacobsen H; Iwatsubo T; Trojanowski J Q; Takahashi H; Wakabayashi K; Bogdanovic N; Riederer P; Kretzschmar H A; Haass C
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.
The American journal of pathology 2001;159(6):2215-25.
2001: Steiner H; Haass C
Nuclear signaling: a common function of presenilin substrates?
Journal of molecular neuroscience : MN 2001;17(2):193-8.
2001: Walter J; Kaether C; Steiner H; Haass C
The cell biology of Alzheimer's disease: uncovering the secrets of secretases.
Current opinion in neurobiology 2001;11(5):585-90.
2001: Haass C; Steiner H
Protofibrils, the unifying toxic molecule of neurodegenerative disorders?
Nature neuroscience 2001;4(9):859-60.
2001: Sastre M; Steiner H; Fuchs K; Capell A; Multhaup G; Condron M M; Teplow D B; Haass C
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.
EMBO reports 2001;2(9):835-41.
2001: Steiner H; Winkler E; Shearman M S; Prywes R; Haass C
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Neurobiology of disease 2001;8(4):717-22.
2001: Haass C; Kahle P J
Neuroscience. Parkin and its substrates.
Science (New York, N.Y.) 2001;293(5528):224-5.
2001: Rathke-Hartlieb S; Kahle P J; Neumann M; Ozmen L; Haid S; Okochi M; Haass C; Schulz J B
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.
Journal of neurochemistry 2001;77(4):1181-4.
2001: Walter J; Fluhrer R; Hartung B; Willem M; Kaether C; Capell A; Lammich S; Multhaup G; Haass C
Phosphorylation regulates intracellular trafficking of beta-secretase.
The Journal of biological chemistry 2001;276(18):14634-41.
2001: Eckert A; Steiner B; Marques C; Leutz S; Romig H; Haass C; Müller W E
Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.
Journal of neuroscience research 2001;64(2):183-92.
2001: Steiner H; Revesz T; Neumann M; Romig H; Grim M G; Pesold B; Kretzschmar H A; Hardy J; Holton J L; Baumeister R; Houlden H; Haass C
A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
The Journal of biological chemistry 2001;276(10):7233-9.
2001: Kahle P J; Haass C
The emerging utility of animal models of chronic neurodegenerative diseases.
Expert opinion on therapeutic targets 2001;5(1):125-32.
2001: Wolfe M S; Haass C
The Role of presenilins in gamma-secretase activity.
The Journal of biological chemistry 2001;276(8):5413-6.
2001: Yamazaki T; Chang T Y; Haass C; Ihara Y
Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells.
The Journal of biological chemistry 2001;276(6):4454-60.
2000: Steiner H; Haass C
Intramembrane proteolysis by presenilins.
Nature reviews. Molecular cell biology 2000;1(3):217-24.
2000: Okochi M; Eimer S; Bottcher A; Baumeister R; Romig H; Walter J; Capell A; Steiner H; Haass C
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.
The Journal of biological chemistry 2000;275(52):40925-32.
2000: Wirths O; Weickert S; Majtenyi K; Havas L; Kahle P J; Okochi M; Haass C; Multhaup G; Beyreuther K; Bayer T A
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.
Neuroreport 2000;11(17):3737-41.
2000: Kahle P J; Leimer U; Haass C
Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
Trends in biochemical sciences 2000;25(11):524-7.
2000: Steiner H; Kostka M; Romig H; Basset G; Pesold B; Hardy J; Capell A; Meyn L; Grim M L; Baumeister R; Fechteler K; Haass C
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
Nature cell biology 2000;2(11):848-51.
2000: Mathews P M; Cataldo A M; Kao B H; Rudnicki A G; Qin X; Yang J L; Jiang Y; Picciano M; Hulette C; Lippa C F; Bird T D; Nochlin D; Walter J; Haass C; Lévesque L; Fraser P E; Andreadis A; Nixon R A
Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
Molecular medicine (Cambridge, Mass.) 2000;6(10):878-91.
2000: Capell A; Steiner H; Willem M; Kaiser H; Meyer C; Walter J; Lammich S; Multhaup G; Haass C
Maturation and pro-peptide cleavage of beta-secretase.
The Journal of biological chemistry 2000;275(40):30849-54.
2000: Kahle P J; Neumann M; Ozmen L; Muller V; Jacobsen H; Schindzielorz A; Okochi M; Leimer U; van Der Putten H; Probst A; Kremmer E; Kretzschmar H A; Haass C
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6365-73.
2000: Yu G; Chen F; Nishimura M; Steiner H; Tandon A; Kawarai T; Arawaka S; Supala A; Song Y Q; Rogaeva E; Holmes E; Zhang D M; Milman P; Fraser P E; Haass C; George-Hyslop P S
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.
The Journal of biological chemistry 2000;275(35):27348-53.
2000: Walter J; Schindzielorz A; Hartung B; Haass C
Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.
The Journal of biological chemistry 2000;275(31):23523-9.
2000: Kulic L; Walter J; Multhaup G; Teplow D B; Baumeister R; Romig H; Capell A; Steiner H; Haass C
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5913-8.
2000: Capell A; Steiner H; Romig H; Keck S; Baader M; Grim M G; Baumeister R; Haass C
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch.
Nature cell biology 2000;2(4):205-11.
2000: Haass C; Kahle P J
Parkinson's pathology in a fly.
Nature 2000;404(6776):341, 343.
2000: Okochi M; Walter J; Koyama A; Nakajo S; Baba M; Iwatsubo T; Meijer L; Kahle P J; Haass C
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.
The Journal of biological chemistry 2000;275(1):390-7.
2000: Hayashi H; Mizuno T; Michikawa M; Haass C; Yanagisawa K
Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains.
Biochimica et biophysica acta 2000;1483(1):81-90.
2000: Yu G; Chen F; Nishimura M; Steiner H; Tandon A; Kawarai T; Arawaka S; Supala A; Song Y Q; Rogaeva E; Holmes E; Zhang D M; Milman P; Fraser P; Haass C; St George-Hyslop P
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.
Acta neurologica Scandinavica. Supplementum 2000;176():6-11.
2000: Kahle P J; Neumann M; Ozmen L; Haass C
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.
Annals of the New York Academy of Sciences 2000;920():33-41.
2000: Haass C
Presenilin proteins and their function during embryonic development and Alzheimer's disease.
Ernst Schering Research Foundation workshop 2000;(29):57-64.
1999: Steiner H; Pesold B; Haass C
An in vivo assay for the identification of target proteases which cleave membrane-associated substrates.
FEBS letters 1999;463(3):245-9.
1999: Steiner H; Romig H; Pesold B; Philipp U; Baader M; Citron M; Loetscher H; Jacobsen H; Haass C
Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
Biochemistry 1999;38(44):14600-5.
1999: Sandmann-Keil D; Braak H; Okochi M; Haass C; Braak E
Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique.
Acta neuropathologica 1999;98(5):461-4.
1999: Haass C; De Strooper B
The presenilins in Alzheimer's disease--proteolysis holds the key.
Science (New York, N.Y.) 1999;286(5441):916-9.
1999: Leimer U; Lun K; Romig H; Walter J; Grünberg J; Brand M; Haass C
Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
Biochemistry 1999;38(41):13602-9.
1999: Steiner H; Duff K; Capell A; Romig H; Grim M G; Lincoln S; Hardy J; Yu X; Picciano M; Fechteler K; Citron M; Kopan R; Pesold B; Keck S; Baader M; Tomita T; Iwatsubo T; Baumeister R; Haass C
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: Guénette S Y; Chen J; Ferland A; Haass C; Capell A; Tanzi R E
hFE65L influences amyloid precursor protein maturation and secretion.
Journal of neurochemistry 1999;73(3):985-93.
1999: Haass C; Mandelkow E
Proteolysis by presenilins and the renaissance of tau.
Trends in cell biology 1999;9(6):241-4.
1999: Haass C
Apoptosis. Dead end for neurodegeneration?
Nature 1999;399(6733):204-5, 207.
1999: Diehlmann A; Ida N; Weggen S; Grünberg J; Haass C; Masters C L; Bayer T A; Beyreuther K
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
Journal of neuroscience research 1999;56(4):405-19.
1999: Mizuno T; Nakata M; Naiki H; Michikawa M; Wang R; Haass C; Yanagisawa K
Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture.
The Journal of biological chemistry 1999;274(21):15110-4.
1999: Lammich S; Kojro E; Postina R; Gilbert S; Pfeiffer R; Jasionowski M; Haass C; Fahrenholz F
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3922-7.
1999: Steiner H; Romig H; Grim M G; Philipp U; Pesold B; Citron M; Baumeister R; Haass C
The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing.
The Journal of biological chemistry 1999;274(12):7615-8.
1999: Steiner H; Capell A; Haass C
Proteolytic processing and degradation of Alzheimer's disease relevant proteins.
Biochemical Society transactions 1999;27(2):234-42.
1999: Thal D R; Sassin I; Schultz C; Haass C; Braak E; Braak H
Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta.
Journal of neuropathology and experimental neurology 1999;58(2):210-6.
1999: Walter J; Schindzielorz A; Grünberg J; Haass C
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1391-6.
1999: Haass C; Baumeister R
The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research.
European archives of psychiatry and clinical neuroscience 1999;249 Suppl 3():23-7.
1999: Steiner H; Capell A; Leimer U; Haass C
Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
European archives of psychiatry and clinical neuroscience 1999;249(6):266-70.
1999: Haass C
Biology of Alzheimer's disease.
European archives of psychiatry and clinical neuroscience 1999;249(6):265.
1998: Steiner H; Capell A; Pesold B; Citron M; Kloetzel P M; Selkoe D J; Romig H; Mendla K; Haass C
Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
The Journal of biological chemistry 1998;273(48):32322-31.
1998: Grünberg J; Walter J; Eckman C; Capell A; Schindzielorz A; Younkin S; Mehta N; Hardy J; Haass C
Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40.
Neuroreport 1998;9(14):3293-9.
1998: Mizuno T; Haass C; Michikawa M; Yanagisawa K
Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells.
Biochimica et biophysica acta 1998;1373(1):119-30.
1998: Oyama F; Sawamura N; Kobayashi K; Morishima-Kawashima M; Kuramochi T; Ito M; Tomita T; Maruyama K; Saido T C; Iwatsubo T; Capell A; Walter J; Grünberg J; Ueyama Y; Haass C; Ihara Y
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: Brockhaus M; Grünberg J; Röhrig S; Loetscher H; Wittenburg N; Baumeister R; Jacobsen H; Haass C
Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.
Neuroreport 1998;9(7):1481-6.
1998: Walter J; Grünberg J; Schindzielorz A; Haass C
Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.
Biochemistry 1998;37(17):5961-7.
1998: Grunberg J; Walter J; Loetscher H; Deuschle U; Jacobsen H; Haass C
Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family.
Biochemistry 1998;37(8):2263-70.
1998: Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe D J; Haass C
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Haass C; Selkoe D J
Alzheimer's disease. A technical KO of amyloid-beta peptide.
Nature 1998;391(6665):339-40.
1998: Haass C; Baumeister R
What do we learn from a few familial Alzheimer's disease cases?
Journal of neural transmission. Supplementum 1998;54():137-45.
1998: Haass C; Grünberg J; Capell A; Wild-Bode C; Leimer U; Walter J; Yamazaki T; Ihara I; Zweckbronner I; Jakubek C; Baumeister R
Proteolytic processing of Alzheimer's disease associated proteins.
Journal of neural transmission. Supplementum 1998;53():159-67.
1997: Capell A; Saffrich R; Olivo J C; Meyn L; Walter J; Grünberg J; Mathews P; Nixon R; Dotti C; Haass C
Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.
Journal of neurochemistry 1997;69(6):2432-40.
1997: Kim S H; Kim Y K; Jeong S J; Haass C; Kim Y H; Suh Y H
Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine.
Molecular pharmacology 1997;52(3):430-6.
1997: Loetscher H; Deuschle U; Brockhaus M; Reinhardt D; Nelboeck P; Mous J; Grünberg J; Haass C; Jacobsen H
Presenilins are processed by caspase-type proteases.
The Journal of biological chemistry 1997;272(33):20655-9.
1997: Yamazaki T; Haass C; Saido T C; Omura S; Ihara Y
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Biochemistry 1997;36(27):8377-83.
1997: Wild-Bode C; Yamazaki T; Capell A; Leimer U; Steiner H; Ihara Y; Haass C
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
The Journal of biological chemistry 1997;272(26):16085-8.
1997: Haass C
Presenilins: genes for life and death.
Neuron 1997;18(5):687-90.
1997: Walter J; Grünberg J; Capell A; Pesold B; Schindzielorz A; Citron M; Mendla K; George-Hyslop P S; Multhaup G; Selkoe D J; Haass C
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: Baumeister R; Leimer U; Zweckbronner I; Jakubek C; Grünberg J; Haass C
Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.
Genes and function 1997;1(2):149-59.
1997: Xia W; Zhang J; Kholodenko D; Citron M; Podlisny M B; Teplow D B; Haass C; Seubert P; Koo E H; Selkoe D J
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
The Journal of biological chemistry 1997;272(12):7977-82.
1997: Tomita T; Maruyama K; Saido T C; Kume H; Shinozaki K; Tokuhiro S; Capell A; Walter J; Grünberg J; Haass C; Iwatsubo T; Obata K
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2025-30.
1997: Walter J; Capell A; Hung A Y; Langen H; Schnölzer M; Thinakaran G; Sisodia S S; Selkoe D J; Haass C
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry 1997;272(3):1896-903.
1997: Podlisny M B; Citron M; Amarante P; Sherrington R; Xia W; Zhang J; Diehl T; Levesque G; Fraser P; Haass C; Koo E H; Seubert P; St George-Hyslop P; Teplow D B; Selkoe D J
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Neurobiology of disease 1997;3(4):325-37.
1996: Walter J; Capell A; Grünberg J; Pesold B; Schindzielorz A; Prior R; Podlisny M B; Fraser P; Hyslop P S; Selkoe D J; Haass C
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Molecular medicine (Cambridge, Mass.) 1996;2(6):673-91.
1996: Haass C
Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease.
Current opinion in neurology 1996;9(4):254-9.
1996: Citron M; Diehl T S; Capell A; Haass C; Teplow D B; Selkoe D J
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
Neuron 1996;17(1):171-9.
1996: Qiu W Q; Borth W; Ye Z; Haass C; Teplow D B; Selkoe D J
Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.
The Journal of biological chemistry 1996;271(14):8443-51.
1996: Selkoe D J; Yamazaki T; Citron M; Podlisny M B; Koo E H; Teplow D B; Haass C
The role of APP processing and trafficking pathways in the formation of amyloid beta-protein.
Annals of the New York Academy of Sciences 1996;777():57-64.
1996: Haass C
The molecular significance of amyloid beta-peptide for Alzheimer's disease.
European archives of psychiatry and clinical neuroscience 1996;246(3):118-23.
1995: Haass C; Lemere C A; Capell A; Citron M; Seubert P; Schenk D; Lannfelt L; Selkoe D J
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Nature medicine 1995;1(12):1291-6.
1995: Munger J S; Haass C; Lemere C A; Shi G P; Wong W S; Teplow D B; Selkoe D J; Chapman H A
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
The Biochemical journal 1995;311 ( Pt 1)():299-305.
1995: Lemere C A; Munger J S; Shi G P; Natkin L; Haass C; Chapman H A; Selkoe D J
The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study.
The American journal of pathology 1995;146(4):848-60.
1995: Haass C; Capell A; Citron M; Teplow D B; Selkoe D J
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
The Journal of biological chemistry 1995;270(11):6186-92.
1995: Haass C; Koo E H; Capell A; Teplow D B; Selkoe D J
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
The Journal of cell biology 1995;128(4):537-47.
1994: Lo A C; Haass C; Wagner S L; Teplow D B; Sisodia S S
Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1994;269(49):30966-73.
1994: Haass C; Hung A Y; Selkoe D J; Teplow D B
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
The Journal of biological chemistry 1994;269(26):17741-8.
1994: Haass C; Koo E H; Teplow D B; Selkoe D J
Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1564-8.
1993: Haass C; Selkoe D J
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.
Cell 1993;75(6):1039-42.
1993: Citron M; Haass C; Selkoe D J
Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596.
Neurobiology of aging 1993;14(6):571-3.
1993: Hung A Y; Haass C; Nitsch R M; Qiu W Q; Citron M; Wurtman R J; Growdon J H; Selkoe D J
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
The Journal of biological chemistry 1993;268(31):22959-62.
1993: Haass C; Hung A Y; Schlossmacher M G; Oltersdorf T; Teplow D B; Selkoe D J
Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Annals of the New York Academy of Sciences 1993;695():109-16.
1993: Haass C; Hung A Y; Schlossmacher M G; Teplow D B; Selkoe D J
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
The Journal of biological chemistry 1993;268(5):3021-4.
1992: Citron M; Oltersdorf T; Haass C; McConlogue L; Hung A Y; Seubert P; Vigo-Pelfrey C; Lieberburg I; Selkoe D J
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Nature 1992;360(6405):672-4.
1992: Hung A Y; Koo E H; Haass C; Selkoe D J
Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9439-43.
1992: Haass C; Schlossmacher M G; Hung A Y; Vigo-Pelfrey C; Mellon A; Ostaszewski B L; Lieberburg I; Koo E H; Schenk D; Teplow D B
Amyloid beta-peptide is produced by cultured cells during normal metabolism.
Nature 1992;359(6393):322-5.
1992: Haass C; Koo E H; Mellon A; Hung A Y; Selkoe D J
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.
Nature 1992;357(6378):500-3.
1992: Schlossmacher M G; Ostaszewski B L; Hecker L I; Celi A; Haass C; Chin D; Lieberburg I; Furie B C; Furie B; Selkoe D J
Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
Neurobiology of aging 1992;13(3):421-34.
1992: Frentzel S; Troxell M; Haass C; Pesold-Hurt B; Glätzer K H; Kloetzel P M
Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35.
European journal of biochemistry / FEBS 1992;205(3):1043-51.
1991: Haass C; Hung A Y; Selkoe D J
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(12):3783-93.
1991: Kloetzel P M; Frentzel S; Gernold M; Haass C; Klein U; Pesold-Hurt B; Seelig A
The proteasome of Drosophila and features of the evolutionarily conserved PROS-gene family.
Biomedica biochimica acta 1991;50(4-6):451-7.
1990: Haass C; Pesold-Hurt B; Kloetzel P M
The Drosophila PROS-29 gene is a new member of the PROS-gene family.
Nucleic acids research 1990;18(13):4018.
1990: Haass C; Klein U; Kloetzel P M
Developmental expression of Drosophila melanogaster small heat-shock proteins.
Journal of cell science 1990;96 ( Pt 3)():413-8.
1990: Haass C; Pesold-Hurt B; Multhaup G; Beyreuther K; Kloetzel P M
The Drosophila PROS-28.1 gene is a member of the proteasome gene family.
Gene 1990;90(2):235-41.
1990: Haass C; Kloetzel P M
Molecular analysis of alpha ecdysone induced 16S complexes in Drosophila Schneider's S3 cells.
Biochemical and biophysical research communications 1990;168(1):314-9.
1989: Haass C; Pesold-Hurt B; Multhaup G; Beyreuther K; Kloetzel P M
The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.
The EMBO journal 1989;8(8):2373-9.
1989: Haass C; Kloetzel P M
The Drosophila proteasome undergoes changes in its subunit pattern during development.
Experimental cell research 1989;180(1):243-52.
1988: Falkenburg P E; Haass C; Kloetzel P M; Niedel B; Kopp F; Kuehn L; Dahlmann B
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase.
Nature 1988;331(6152):190-2.

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