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Daniel Haber

Research Profile

Physiology

Disorders

Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Wilms' Tumor Genes

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Min Yu; Aditya Bardia; Jose Baselga; Elena F Brachtel; Jordan C Ciciliano; Kyle F Concannon; Maria C Donaldson; Daniel A Haber; Steven J Isakoff; Sridhar Ramaswamy; Lecia V Sequist; Dennis Sgroi; Ajay M Shah; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Marissa N Wells; Ben S Wittner; Shyamala Maheswaran
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Devarati Mitra; Ann Morgan; Kathleen C Robinson; Jillian C Vanover; Jin Wang; Yinsheng Wang; Jennifer A Wargo; Marcus W Bosenberg; Suprabha P Devi; John A D'Orazio; Candace R Guerrero; Daniel A Haber; Kevin Haigis; Mai P Hoang; Jochen K Lennerz; Jennifer Lo; Xi Luo; Martin McMahon; Martin C Mihm; David E Fisher
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.
David T Miyamoto; Sridhar Ramaswamy; Lecia V Sequist; Malgorzata E Smas; Matthew R Smith; Shannon L Stott; David T Ting; Mehmet Toner; Julie Trautwein; Matthew Ulman; Ben S Wittner; Chin-Lee Wu; Neil H Bander; Brian W Brannigan; Richard J Lee; Jenna B Lord; Shyamala Maheswaran; Daniel A Haber
Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.

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All Publications

2013: Min Yu; Aditya Bardia; Jose Baselga; Elena F Brachtel; Jordan C Ciciliano; Kyle F Concannon; Maria C Donaldson; Daniel A Haber; Steven J Isakoff; Sridhar Ramaswamy; Lecia V Sequist; Dennis Sgroi; Ajay M Shah; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Marissa N Wells; Ben S Wittner; Shyamala Maheswaran
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Science (New York, N.Y.) 2013;339(6119):580-4.
2012: Devarati Mitra; Ann Morgan; Kathleen C Robinson; Jillian C Vanover; Jin Wang; Yinsheng Wang; Jennifer A Wargo; Marcus W Bosenberg; Suprabha P Devi; John A D'Orazio; Candace R Guerrero; Daniel A Haber; Kevin Haigis; Mai P Hoang; Jochen K Lennerz; Jennifer Lo; Xi Luo; Martin McMahon; Martin C Mihm; David E Fisher
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.
Nature 2012;491(7424):449-53.
2012: David T Miyamoto; Sridhar Ramaswamy; Lecia V Sequist; Malgorzata E Smas; Matthew R Smith; Shannon L Stott; David T Ting; Mehmet Toner; Julie Trautwein; Matthew Ulman; Ben S Wittner; Chin-Lee Wu; Neil H Bander; Brian W Brannigan; Richard J Lee; Jenna B Lord; Shyamala Maheswaran; Daniel A Haber
Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.
Cancer discovery 2012;2(11):995-1003.
2012: Min Yu; Brinda Alagesan; Nabeel Bardeesy; Brian W Brannigan; Jordan C Ciciliano; Gianmarco Contino; Anna J Gilman; Shyamala Maheswaran; Patrice M Milos; Fatih Ozsolak; Suchismita Paul; Sridhar Ramaswamy; David P Ryan; Lecia V Sequist; Malgorzata E Smas; Shannon L Stott; David T Ting; Mehmet Toner; Matthew J Ulman; Daniel Winokur; Ben S Wittner; Kristina Xega; Daniel A Haber
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
Nature 2012;487(7408):510-3.
2012: Ajay M Shah; Shannon L Stott; Matthew Ulman; Min Yu; Jordan Ciciliano; Daniel A Haber; Kenneth Kotz; Shyamala Maheswaran; Zev Nakamura; Mehmet Toner
Biopolymer system for cell recovery from microfluidic cell capture devices.
Analytical chemistry 2012;84(8):3682-8.
2012: Woo Jae Kim; Miguel N Rivera; Erik J Coffman; Daniel A Haber
The WTX tumor suppressor enhances p53 acetylation by CBP/p300.
Molecular cell 2012;45(5):587-97.
2012: Naokazu Chiba; Valentine Comaills; Daniel A Haber; Tetsu Hayashida; Elena F Brachtel; Toshiyuki Shimada; Bunsyo Shiotani; Ken Tajima; Fumiyuki Takahashi; Maria d M Vivanco; Henning Willers; Daniel Winokur; Lee Zou; Shyamala Maheswaran
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2760-5.
2012: Anurag Singh; Michael F Sweeney; Min Yu; Cyril Benes; Alexa Burger; Patricia Greninger; Daniel A Haber; Jeff Settleman
TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.
Cell 2012;148(4):639-50.
2011: Annie Moisan; Miguel N Rivera; Sutada Lotinun; Sara Akhavanfard; Erik J Coffman; Edward B Cook; Svetlana Stoykova; Siddhartha Mukherjee; Jesse A Schoonmaker; Alexa Burger; Woo Jae Kim; Henry M Kronenberg; Roland Baron; Daniel A Haber; Nabeel Bardeesy
The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.
Developmental cell 2011;20(5):583-96.
2011: Daniel A Haber; Nathanael S Gray; Jose Baselga
The evolving war on cancer.
Cell 2011;145(1):19-24.
2011: Min Yu; Shannon Stott; Mehmet Toner; Shyamala Maheswaran; Daniel A Haber
Circulating tumor cells: approaches to isolation and characterization.
The Journal of cell biology 2011;192(3):373-82.
2011: David T Ting; Doron Lipson; Suchismita Paul; Brian W Brannigan; Sara Akhavanfard; Erik J Coffman; Gianmarco Contino; Vikram Deshpande; A John Iafrate; Stan Letovsky; Miguel N Rivera; Nabeel Bardeesy; Shyamala Maheswaran; Daniel A Haber
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
Science (New York, N.Y.) 2011;331(6017):593-6.
2010: Gromoslaw A Smolen; Jianmin Zhang; Matthew J Zubrowski; Elena J Edelman; Biao Luo; Min Yu; Lydia W Ng; Cally M Scherber; Benjamin J Schott; Sridhar Ramaswamy; daniel irimia; David E Root; Daniel A Haber
A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration.
Genes & development 2010;24(23):2654-65.
2010: Shannon L Stott; Chia-Hsien Hsu; Dina Tsukrov; Min Yu; David T Miyamoto; Belinda A Waltman; S Michael Rothenberg; Ajay M Shah; Malgorzata E Smas; George K Korir; Frederick P Floyd; Anna J Gilman; Jenna B Lord; Daniel Winokur; Simeon Springer; daniel irimia; Sunitha Nagrath; Lecia V Sequist; Richard J Lee; Kurt J Isselbacher; Shyamala Maheswaran; Daniel A Haber; Mehmet Toner
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18392-7.
2010: Julie Wells; Miguel N Rivera; Woo Jae Kim; Kristen Starbuck; Daniel A Haber
The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes.
Molecular cancer research : MCR 2010;8(7):975-85.
2010: Aviva Presser Aiden; Miguel N Rivera; Esther Rheinbay; Manching Ku; Erik J Coffman; Thanh T Truong; Sara O Vargas; Eric S Lander; Daniel A Haber; Bradley E Bernstein
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.
Cell stem cell 2010;6(6):591-602.
2010: Dora Dias-Santagata; Sara Akhavanfard; Serena S David; Kathy Vernovsky; Georgiana Kuhlmann; Susan L Boisvert; Hannah Stubbs; Ultan McDermott; Jeffrey Settleman; Eunice L Kwak; Jeffrey W Clark; Steven J Isakoff; Lecia V Sequist; Jeffrey A Engelman; Thomas J Lynch; Daniel A Haber; David N Louis; Leif W Ellisen; Darrell R Borger; A John Iafrate
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.
EMBO molecular medicine 2010;2(5):146-58.
2010: Sreenath V Sharma; Daniel A Haber; Jeff Settleman
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents.
Nature reviews. Cancer 2010;10(4):241-53.
2010: Shannon L Stott; Richard J Lee; Sunitha Nagrath; Min Yu; David T Miyamoto; Lindsey Ulkus; Elizabeth J Inserra; Matthew Ulman; Simeon Springer; Zev Nakamura; Alessandra L Moore; Dina Tsukrov; Maria E Kempner; Douglas M Dahl; Chin-Lee Wu; A John Iafrate; Matthew R Smith; Ronald G Tompkins; Lecia V Sequist; Mehmet Toner; Daniel A Haber; Shyamala Maheswaran
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.
Science translational medicine 2010;2(25):25ra23.
2010: S Michael Rothenberg; Gayatry Mohapatra; Miguel N Rivera; Daniel Winokur; Patricia Greninger; Mai Nitta; Peter M Sadow; Gaya Sooriyakumar; Brian W Brannigan; Matthew J Ulman; Rushika M Perera; Rui Wang; Angela Tam; Xiao-Jun Ma; Mark Erlander; Dennis C Sgroi; James William Rocco; Mark W Lingen; Ezra E W Cohen; David N Louis; Jeffrey Settleman; Daniel A Haber
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer research 2010;70(6):2158-64.
2010: Shyamala Maheswaran; Daniel A Haber
Circulating tumor cells: a window into cancer biology and metastasis.
Current opinion in genetics & development 2010;20(1):96-9.
2009: Jianmin Zhang; Jun-Yuan Ji; Min Yu; Michael Overholtzer; Gromoslaw A Smolen; Rebecca Wang; Joan S Brugge; Nicholas J Dyson; Daniel A Haber
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.
Nature cell biology 2009;11(12):1444-50.
2009: Jianmin Zhang; Young-Han Song; Brian W Brannigan; Doke C R Wahrer; Taryn A Schiripo; Patricia L Harris; Sara M Haserlat; Lindsey E Ulkus; Kristen M Shannon; Judy E Garber; Matthew L Freedman; Brian E Henderson; Lee Zou; Dennis C Sgroi; Daniel A Haber; Daphne W Bell
Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin.
Molecular cancer research : MCR 2009;7(9):1510-6.
2009: Min Yu; Gromoslaw A Smolen; Jianmin Zhang; Ben Wittner; Benjamin J Schott; Elena Brachtel; Sridhar Ramaswamy; Shyamala Maheswaran; Daniel A Haber
A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.
Genes & development 2009;23(15):1737-42.
2009: Miguel N Rivera; Woo Jae Kim; Julie Wells; Amanda Stone; Alexa Burger; Erik J Coffman; Jianmin Zhang; Daniel A Haber
The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(20):8338-43.
2009: Ultan McDermott; Rachel Y Ames; A John Iafrate; Shyamala Maheswaran; Hannah Stubbs; Patricia Greninger; Kaitlin McCutcheon; Randy Milano; Angela Tam; Diana Y Lee; Laury Lucien; Brian W Brannigan; Lindsey Ulkus; Xiao-Jun Ma; Mark G Erlander; Daniel A Haber; Sreenath V Sharma; Jeffrey Settleman
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors.
Cancer research 2009;69(9):3937-46.
2009: Lecia V Sequist; Sunitha Nagrath; Mehmet Toner; Daniel A Haber; Thomas J Lynch
The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(3):281-3.
2008: Tan Min Chin; Margaret P Quinlan; Anurag Singh; Lecia V Sequist; Thomas J Lynch; Daniel A Haber; Sreenath V Sharma; Jeffrey Settleman
Reduced Erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6867-76.
2008: S Kim; Gayatry Mohapatra; Daniel A Haber
In vitro phosphorylation of BRCA2 by the checkpoint kinase CHEK2.
British journal of cancer 2008;99(8):1302-6.
2008: S Michael Rothenberg; Jeffrey A Engelman; Sheila Le; David J Riese; Daniel A Haber; Jeffrey Settleman
Modeling oncogene addiction using RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12480-4.
2008: Shyamala Maheswaran; Lecia V Sequist; Sunitha Nagrath; Lindsey Ulkus; Brian Brannigan; Chey V Collura; Elizabeth Inserra; Sven Diederichs; A John Iafrate; Daphne W Bell; Subba R Digumarthy; Alona Muzikansky; daniel irimia; Jeffrey Settleman; Ronald G Tompkins; Thomas J Lynch; Mehmet Toner; Daniel A Haber
Detection of mutations in EGFR in circulating lung-cancer cells.
The New England journal of medicine 2008;359(4):366-77.
2008: Sven Diederichs; Stephanie Jung; S Michael Rothenberg; Gromoslaw A Smolen; Barbara G Mlody; Daniel A Haber
Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(27):9284-9.
2008: Daphne W Bell; Brian W Brannigan; Keitaro Matsuo; Dianne M Finkelstein; Raffaella Sordella; Jeffrey Settleman; Tetsuya Mitsudomi; Daniel A Haber
Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4079-84.
2008: Clara Montagut; Sreenath V Sharma; Toshi Shioda; Ultan McDermott; Matthew Ulman; Lindsey Ulkus; Dora Dias-Santagata; Hannah Stubbs; Diana Y Lee; Anurag Singh; Lisa Drew; Daniel A Haber; Jeffrey Settleman
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.
Cancer research 2008;68(12):4853-61.
2008: Lecia V Sequist; Renato G Martins; David Spigel; Steven M Grunberg; Alexander Spira; Pasi A Janne; Victoria A Joshi; David McCollum; Tracey L Evans; Alona Muzikansky; Georgiana L Kuhlmann; Moon Han; Jonathan S Goldberg; Jeffrey Settleman; A John Iafrate; Jeffrey A Engelman; Daniel A Haber; Bruce E Johnson; Thomas J Lynch
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(15):2442-9.
2008: Ben S Wittner; Dennis C Sgroi; Paula D Ryan; Tako J Bruinsma; Annuska M Glas; Anitha Male; Sonika Dahiya; Karleen Habin; Rene Bernards; Daniel A Haber; Laura J Van't Veer; Sridhar Ramaswamy
Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(10):2988-93.
2008: Ultan McDermott; A John Iafrate; Nathanael S Gray; Toshi Shioda; Marie Classon; Shyamala Maheswaran; Wenjun Zhou; Hwan Geun Choi; Shannon L Smith; Lori Dowell; Lindsey Ulkus; Georgiana Kuhlmann; Patricia Greninger; James G Christensen; Daniel A Haber; Jeffrey Settleman
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.
Cancer research 2008;68(9):3389-95.
2008: Woo Jae Kim; Ross A Okimoto; Louise E Purton; Meagan Goodwin; Sara M Haserlat; Farshid Dayyani; David A Sweetser; Andrea I McClatchey; Olivier A Bernard; A Thomas Look; Daphne W Bell; David T Scadden; Daniel A Haber
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.
Blood 2008;111(9):4716-22.
2008: Jianmin Zhang; Gromoslaw A Smolen; Daniel A Haber
Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway.
Cancer research 2008;68(8):2789-94.
2008: Nadia Godin-Heymann; Lindsey Ulkus; Brian W Brannigan; Ultan McDermott; Jennifer Lamb; Shyamala Maheswaran; Jeffrey Settleman; Daniel A Haber
The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor.
Molecular cancer therapeutics 2008;7(4):874-9.
2008: Hongjie Li; Gromoslaw A Smolen; Lisa F Beers; Li Xia; William Gerald; Joanne Wang; Daniel A Haber; Sean Bong Lee
Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor.
PloS one 2008;3(6):e2353.
2007: Sunitha Nagrath; Lecia V Sequist; Shyamala Maheswaran; Daphne W Bell; daniel irimia; Lindsey Ulkus; Matthew R Smith; Eunice L Kwak; Subba Digumarthy; Alona Muzikansky; Paula Ryan; Ulysses J Balis; Ronald G Tompkins; Daniel A Haber; Mehmet Toner
Isolation of rare circulating tumour cells in cancer patients by microchip technology.
Nature 2007;450(7173):1235-9.
2007: Daphne W Bell; Sang H Kim; Andrew K Godwin; Taryn A Schiripo; Patricia Neal; Sara M Haserlat; Doke C R Wahrer; Christopher A Haiman; Mary B Daly; Kristin B Niendorf; Matthew R Smith; Dennis C Sgroi; Judy E Garber; Olufunmilayo I Olopade; Loïc Le Marchand; Brian Henderson; David Altshuler; Daniel A Haber; Matthew L Freedman
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
International journal of cancer. Journal international du cancer 2007;121(12):2661-7.
2007: Sven Diederichs; Daniel A Haber
Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.
Cell 2007;131(6):1097-108.
2007: Ultan McDermott; Sreenath V Sharma; Lori Dowell; Patricia Greninger; Clara Montagut; Jennifer Lamb; Heidi Archibald; Raul Raudales; Angela Tam; Diana Lee; S Michael Rothenberg; Jeffrey G Supko; Raffaella Sordella; Lindsey Ulkus; A John Iafrate; Shyamala Maheswaran; Ching-Ni Njauw; Hensin Tsao; Lisa Drew; Jeff H Hanke; Xiao-Jun Ma; Mark G Erlander; Nathanael S Gray; Daniel A Haber; Jeffrey Settleman
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19936-41.
2007: Moonjoo Han; Miguel N Rivera; Julie M Batten; Daniel A Haber; Paola Dal Cin; A John Iafrate
Wilms' tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene.
Genes, chromosomes & cancer 2007;46(10):909-13.
2007: Gromoslaw A Smolen; Benjamin J Schott; Rodney A Stewart; Sven Diederichs; Beth Muir; Heather Provencher; A Thomas Look; Dennis C Sgroi; Randall T Peterson; Daniel A Haber
A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.
Genes & development 2007;21(17):2131-6.
2007: Nadia Godin-Heymann; Ianthe Bryant; Miguel N Rivera; Lindsey Ulkus; Daphne W Bell; David J Riese; Jeffrey Settleman; Daniel A Haber
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation.
Cancer research 2007;67(15):7319-26.
2007: Hannele Erkko; Bing Xia; Jenni Nikkilä; Johanna Schleutker; Kirsi Syrjäkoski; Arto Mannermaa; Anne Kallioniemi; Katri Pylkäs; Sanna-Maria Karppinen; Katrin Rapakko; alexander miron; Qing Sheng; Guilan Li; Henna Mattila; Daphne W Bell; Daniel A Haber; Mervi Grip; Mervi Reiman; Arja Jukkola-Vuorinen; Aki Mustonen; Juha Kere; Lauri A Aaltonen; Veli-Matti Kosma; Vesa Kataja; Ylermi Soini; Ronny Drapkin; David M Livingston; Robert Winqvist
A recurrent mutation in PALB2 in Finnish cancer families.
Nature 2007;446(7133):316-9.
2007: Roseann Mulloy; Audrey Ferrand; Youngjoo Kim; Raffaella Sordella; Daphne W Bell; Daniel A Haber; Karen S Anderson; Jeffrey Settleman
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.
Cancer research 2007;67(5):2325-30.
2007: Sreenath V Sharma; Daphne W Bell; Jeffrey Settleman; Daniel A Haber
Epidermal growth factor receptor mutations in lung cancer.
Nature reviews. Cancer 2007;7(3):169-81.
2007: Lecia V Sequist; Daphne W Bell; Thomas J Lynch; Daniel A Haber
Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(5):587-95.
2007: Miguel N Rivera; Woo Jae Kim; Julie Wells; David R Driscoll; Brian W Brannigan; Moonjoo Han; James C Kim; Andrew P Feinberg; William L Gerald; Sara O Vargas; Lynda Chin; A John Iafrate; Daphne W Bell; Daniel A Haber
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
Science (New York, N.Y.) 2007;315(5812):642-5.
2007: Lecia V Sequist; Victoria A Joshi; Pasi A Janne; Alona Muzikansky; Panos Fidias; Matthew Meyerson; Daniel A Haber; Raju Kucherlapati; Bruce E Johnson; Thomas J Lynch
Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing.
The oncologist 2007;12(1):90-8.
2006: Sreenath V Sharma; Patrycja Gajowniczek; Inna P Way; Diana Y Lee; Jane Jiang; Yuki Yuza; Marie Classon; Daniel A Haber; Jeffrey Settleman
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.
Cancer cell 2006;10(5):425-35.
2006: Michael Overholtzer; Jianmin Zhang; Gromoslaw A Smolen; Beth Muir; Wenmei Li; Dennis C Sgroi; Chu-Xia Deng; Joan S Brugge; Daniel A Haber
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12405-10.
2006: Lecia V Sequist; Victoria A Joshi; Pasi A Janne; Daphne W Bell; Panos Fidias; Neal Lindeman; David N Louis; Jeffrey C Lee; Eugene J Mark; Janina Longtine; Peter Verlander; Raju Kucherlapati; Matthew Meyerson; Daniel A Haber; Bruce E Johnson; Thomas J Lynch
Epidermal growth factor receptor mutation testing in the care of lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4403s-4408s.
2006: Sreenath V Sharma; Michael A Fischbach; Daniel A Haber; Jeffrey Settleman
"Oncogenic shock": explaining oncogene addiction through differential signal attenuation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4392s-4395s.
2006: Thomas J Lynch; Alex A. Adjei; Paul A Bunn; Tim G Eisen; Jeffrey A Engelman; Glenwood Goss; Daniel A Haber; John V Heymach; Pasi A Janne; Bruce E Johnson; David H Johnson; Rogerio Lilenbaum; Matthew Meyerson; Alan B Sandler; Lecia V Sequist; Jeffrey Settleman; Kwok-Kin Wong; Carol S Hart
Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4365s-4371s.
2006: Eunice L Kwak; Janusz Jankowski; Sarah P Thayer; Gregory Y Lauwers; Brian W Brannigan; Patricia Neal; Ross A Okimoto; Sara M Haserlat; David R Driscoll; David Ferry; Beth Muir; Jeffrey Settleman; Charlie S Fuchs; Matthew H Kulke; David P Ryan; jeffrey clark; Dennis C Sgroi; Daniel A Haber; Daphne W Bell
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4283-7.
2006: David M Jackman; Beow Y Yeap; Lecia V Sequist; Neal Lindeman; Alison J Holmes; Victoria A Joshi; Daphne W Bell; Mark S Huberman; Balazs Halmos; Michael S Rabin; Daniel A Haber; Thomas J Lynch; Matthew Meyerson; Bruce E Johnson; Pasi A Janne
Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(13):3908-14.
2006: Sven Diederichs; Daniel A Haber
Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing.
Cancer research 2006;66(12):6097-104.
2006: Gromoslaw A Smolen; Beth Muir; Gayatry Mohapatra; Anne Barmettler; Woo J Kim; Miguel N Rivera; Sara M Haserlat; Ross A Okimoto; Eunice L Kwak; Sonika Dahiya; Judy E Garber; Daphne W Bell; Dennis C Sgroi; Lynda Chin; Chu-Xia Deng; Daniel A Haber
Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
Cancer research 2006;66(7):3452-5.
2006: Eunice L Kwak; Sang Kim; Jianmin Zhang; Robert Cardiff; Emmett V Schmidt; Daniel A Haber
Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant.
Cancer research 2006;66(4):1923-8.
2006: Gromoslaw A Smolen; Raffaella Sordella; Beth Muir; Gayatry Mohapatra; Anne Barmettler; Heidi Archibald; Woo J Kim; Ross A Okimoto; Daphne W Bell; Dennis C Sgroi; James G Christensen; Jeffrey Settleman; Daniel A Haber
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2316-21.
2005: Daphne W Bell; Ira Gore; Ross A Okimoto; Nadia Godin-Heymann; Raffaella Sordella; Roseann Mulloy; Sreenath V Sharma; Brian W Brannigan; Gayatry Mohapatra; Jeffrey Settleman; Daniel A Haber
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
Nature genetics 2005;37(12):1315-6.
2005: Ezra E W Cohen; Mark W Lingen; Leslie E Martin; Patricia Neal; Brian W Brannigan; Sara M Haserlat; Ross A Okimoto; Dennis C Sgroi; Sonika Dahiya; Beth Muir; John R Clark; James William Rocco; Everett E Vokes; Daniel A Haber; Daphne W Bell
Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):8105-8.
2005: Daphne W Bell; Thomas J Lynch; Sara M Haserlat; Patricia Neal; Ross A Okimoto; Brian W Brannigan; Dennis C Sgroi; Beth Muir; Markus J Riemenschneider; Renee Bailey Iacona; Annetta D Krebs; David H Johnson; Giuseppe Giaccone; Roy S Herbst; Christian Manegold; Masahiro Fukuoka; Mark G Kris; José Baselga; Judith S Ochs; Daniel A Haber
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):8081-92.
2005: Miguel N Rivera; Daniel A Haber
Wilms' tumour: connecting tumorigenesis and organ development in the kidney.
Nature reviews. Cancer 2005;5(9):699-712.
2005: Lecia V Sequist; Daniel A Haber; Thomas J Lynch
Epidermal growth factor receptor mutations in non-small cell lung cancer: predicting clinical response to kinase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5668-70.
2005: Daniel A Haber; Jeffrey Settleman
Overcoming acquired resistance to Iressa/Tarceva with inhibitors of a different class.
Cell cycle (Georgetown, Tex.) 2005;4(8):1057-9.
2005: Eunice L Kwak; Kenneth H Moberg; Doke C R Wahrer; Jennifer E Quinn; Paula M Gilmore; Colin A Graham; Iswar K Hariharan; D Paul Harkin; Daniel A Haber; Daphne W Bell
Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer.
Gynecologic oncology 2005;98(1):124-8.
2005: William L Gerald; Daniel A Haber
The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
Seminars in cancer biology 2005;15(3):197-205.
2005: Eunice L Kwak; Raffaella Sordella; Daphne W Bell; Nadia Godin-Heymann; Ross A Okimoto; Brian W Brannigan; Patricia Neal; David R Driscoll; Panos Fidias; Thomas J Lynch; Sridhar K Rabindran; John P McGinnis; Allan Wissner; Sreenath V Sharma; Kurt J Isselbacher; Jeffrey Settleman; Daniel A Haber
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7665-70.
2005: Markus J Riemenschneider; Daphne W Bell; Daniel A Haber; David N Louis
Pulmonary adenocarcinomas with mutant epidermal growth factor receptors.
The New England journal of medicine 2005;352(16):1724-5.
2005: Daniel A Haber; Daphne W Bell; Raffaella Sordella; Eunice L Kwak; Nadia Godin-Heymann; Sreenath V Sharma; Thomas J Lynch; Jeffrey Settleman
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors.
Cold Spring Harbor symposia on quantitative biology 2005;70():419-26.
2004: Dennis C Sgroi; Daniel A Haber; Paula D Ryan; Xiao-Jun Ma; Mark G Erlander
RE: A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
Cancer cell 2004;6(5):445.
2004: Gromoslaw A Smolen; Maria T Vassileva; Julie Wells; Michael J Matunis; Daniel A Haber
SUMO-1 modification of the Wilms' tumor suppressor WT1.
Cancer research 2004;64(21):7846-51.
2004: Raffaella Sordella; Daphne W Bell; Daniel A Haber; Jeffrey Settleman
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways.
Science (New York, N.Y.) 2004;305(5687):1163-7.
2004: Young-Han Song; Gladys Mirey; Martha Betson; Daniel A Haber; Jeffrey Settleman
The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.
Current biology : CB 2004;14(15):1354-9.
2004: Hong Zhang; Andrea Christoforou; L Aravind; Scott W Emmons; Sander van den Heuvel; Daniel A Haber
The C. elegans Polycomb gene SOP-2 encodes an RNA binding protein.
Molecular cell 2004;14(6):841-7.
2004: Xiao-Jun Ma; Zuncai Wang; Paula D Ryan; Steven J Isakoff; Anne Barmettler; Andrew Fuller; Beth Muir; Gayatry Mohapatra; Ranelle Salunga; J Todd Tuggle; Yen Tran; Diem Tran; Ana Tassin; Paul Amon; Wilson Wang; Wei Wang; Edward Enright; Kimberly Stecker; Eden Estepa-Sabal; Barbara Smith; Jerry Younger; Ulysses J Balis; James Michaelson; Atul Bhan; Karleen Habin; Thomas Baer; Joan S Brugge; Daniel A Haber; Mark G Erlander; Dennis C Sgroi
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
Cancer cell 2004;5(6):607-16.
2004: Thomas J Lynch; Daphne W Bell; Raffaella Sordella; Sarada Gurubhagavatula; Ross A Okimoto; Brian W Brannigan; Patricia Neal; Sara M Haserlat; Jeffrey G Supko; Frank G Haluska; David N Louis; David C Christiani; Jeffrey Settleman; Daniel A Haber
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
The New England journal of medicine 2004;350(21):2129-39.
2004: Hong Zhang; Gromoslaw A Smolen; Rachel Palmer; Andrea Christoforou; Sander van den Heuvel; Daniel A Haber
SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
Nature genetics 2004;36(5):507-11.
2003: Daniel A Haber
The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis.
Cell 2003;115(5):507-8.
2003: Hong Zhang; Rachel Palmer; Xiaobo Gao; Jordan A Kreidberg; William Gerald; Lili Hsiao; Roderick V Jensen; Steven R Gullans; Daniel A Haber
Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1.
Current biology : CB 2003;13(18):1625-9.
2003: Paula D Ryan; Daniel A Haber; Kristen M Shannon; Barbara L Smith; Melinda J Fan
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 28-2003. A 51-year-old premenopausal woman with newly diagnosed breast cancer and a strong family history of breast cancer.
The New England journal of medicine 2003;349(11):1076-82.
2003: Paul A Reynolds; Gromoslaw A Smolen; Rachel E Palmer; Dennis C Sgroi; Vijay Yajnik; William L Gerald; Daniel A Haber
Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein.
Genes & development 2003;17(17):2094-107.
2003: Byeong-Chel Lee; Tao Cheng; Gregor B Adams; Eyal C Attar; Nobuyuki Miura; Sean Bong Lee; Yoriko Saito; Ivona T Olszak; David Dombkowski; Douglas P Olson; Julie Hancock; Peter S Choi; Daniel A Haber; Andrew D Luster; David T Scadden
P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.
Genes & development 2003;17(13):1592-604.
2003: Iswar K Hariharan; Daniel A Haber
Yeast, flies, worms, and fish in the study of human disease.
The New England journal of medicine 2003;348(24):2457-63.
2003: Vijay Yajnik; Charles A Paulding; Raffaella Sordella; Andrea I McClatchey; Mako Saito; Doke C R Wahrer; Paul Reynolds; Daphne W Bell; Robert Lake; Sander van den Heuvel; Jeffrey Settleman; Daniel A Haber
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
Cell 2003;112(5):673-84.
2003: Charles A Paulding; Maryellen Ruvolo; Daniel A Haber
The Tre2 (USP6) oncogene is a hominoid-specific gene.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2507-11.
2002: Rachel E Palmer; Sean Bong Lee; Jenise C Wong; Paul A Reynolds; Hong Zhang; Vivi Truong; Jonathan D Oliner; William L Gerald; Daniel A Haber
Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis.
Cancer cell 2002;2(6):497-505.
2002: Leif W Ellisen; Kate D Ramsayer; Cory Johannessen; Annie Yang; Hideyuki Beppu; Karolina Minda; Jonathan D Oliner; Frank McKeon; Daniel A Haber
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.
Molecular cell 2002;10(5):995-1005.
2002: Nicolas Tapon; Kieran F Harvey; Daphne W Bell; Doke C R Wahrer; Taryn A Schiripo; Daniel A Haber; Iswar K Hariharan
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.
Cell 2002;110(4):467-78.
2002: Heather N Andrews; Paul B Mullan; Stewart McWilliams; Sarka Sebelova; Jennifer E Quinn; Paula M Gilmore; Nuala McCabe; Amy Pace; Beverly H Koller; Patrick G Johnston; Daniel A Haber; D Paul Harkin
BRCA1 regulates the interferon gamma-mediated apoptotic response.
The Journal of biological chemistry 2002;277(29):26225-32.
2002: Daphne W Bell; John K Erban; Dennis C Sgroi; Daniel A Haber
Selective loss of heterozygosity in multiple breast cancers from a carrier of mutations in both BRCA1 and BRCA2.
Cancer research 2002;62(10):2741-3.
2002: Jenise C Wong; Sean B Lee; Moshe D Bell; Paul A Reynolds; Emilio Fiore; Ivan Stamenkovic; Vivi Truong; Jonathan D Oliner; William L Gerald; Daniel A Haber
Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product.
Oncogene 2002;21(13):2009-19.
2001: Sean Bong Lee; S H Kim; Daphne W Bell; Doke C R Wahrer; Taryn A Schiripo; M M Jorczak; Dennis C Sgroi; Judy E Garber; Frederick P Li; Kim E Nichols; J M Varley; A K Godwin; K M Shannon; Ed Harlow; Daniel A Haber
Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
Cancer research 2001;61(22):8062-7.
2001: Rachel E Palmer; A Kotsianti; B Cadman; T Boyd; William Gerald; Daniel A Haber
WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin.
Current biology : CB 2001;11(22):1805-9.
2001: Paul B Mullan; Jennifer E Quinn; Paula M Gilmore; Stewart McWilliams; Heather N Andrews; C Gervin; Nuala McCabe; S McKenna; P White; Y H Song; Shyamala Maheswaran; E Liu; Daniel A Haber; Patrick G Johnston; D Paul Harkin
BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents.
Oncogene 2001;20(43):6123-31.
2001: Kenneth H Moberg; Daphne W Bell; Doke C R Wahrer; Daniel A Haber; Iswar K Hariharan
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Nature 2001;413(6853):311-6.
2001: W Wang; Sean B Lee; Rachel Palmer; Leif W Ellisen; Daniel A Haber
A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1.
The Journal of biological chemistry 2001;276(20):16810-6.
2001: Leif W Ellisen; Rachel E Palmer; ROBERT G MAKI; Vivi Truong; P Tamayo; Jonathan D Oliner; Daniel A Haber
Cascades of transcriptional induction during human lymphocyte activation.
European journal of cell biology 2001;80(5):321-8.
2001: Leif W Ellisen; Nadia Carlesso; T Cheng; David T Scadden; Daniel A Haber
The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells.
The EMBO journal 2001;20(8):1897-909.
2001: Sharon B Cantor; Daphne W Bell; Shridar Ganesan; E M Kass; Ronny Drapkin; Steven R Grossman; Doke C R Wahrer; Dennis C Sgroi; William Stratton Lane; Daniel A Haber; David M Livingston
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Cell 2001;105(1):149-60.
2001: Sean B Lee; Daniel A Haber
Wilms tumor and the WT1 gene.
Experimental cell research 2001;264(1):74-99.
2000: S Chaudhuri; Annaiah Cariappa; M Tang; D Bell; Daniel A Haber; Kurt J Isselbacher; D Finkelstein; D Forcione; Shiv Pillai
Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11451-4.
2000: TD Shafman; S Levitz; A J Nixon; L A Gibans; Kim E Nichols; Daphne W Bell; Chikashi Ishioka; Kurt J Isselbacher; Rebecca Gelman; Judy E Garber; Jay R Harris; Daniel A Haber
Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contralateral tumor.
Genes, chromosomes & cancer 2000;27(2):124-9.
1999: Daphne W Bell; J M Varley; T E Szydlo; D H Kang; Doke C R Wahrer; KE Shannon; M Lubratovich; Sigitas Verselis; Kurt J Isselbacher; Joseph Fraumeni; Jillian M Birch; Frederick P Li; Judy E Garber; Daniel A Haber
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
Science (New York, N.Y.) 1999;286(5449):2528-31.
1999: Masaki Okano; Daphne W Bell; Daniel A Haber; En Li
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Cell 1999;99(3):247-57.
1999: Sean B Lee; K Huang; Rachel Palmer; Vivi Truong; D Herzlinger; KA Kolquist; J Wong; Charles A Paulding; S K Yoon; William Gerald; Jonathan D Oliner; Daniel A Haber
The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin.
Cell 1999;98(5):663-73.
1999: Daphne W Bell; Doke C R Wahrer; D H Kang; M S MacMahon; MG FitzGerald; Chikashi Ishioka; Kurt J Isselbacher; michael krainer; Daniel A Haber
Common nonsense mutations in RAD52.
Cancer research 1999;59(16):3883-8.
1999: D Paul Harkin; J M Bean; D Miklos; Y H Song; Vivi Truong; C Englert; F C Christians; Leif W Ellisen; Shyamala Maheswaran; Jonathan D Oliner; Daniel A Haber
Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.
Cell 1999;97(5):575-86.
1999: Kim E Nichols; S Levitz; KE Shannon; Doke C R Wahrer; Daphne W Bell; G Chang; S Hegde; Donna Neuberg; TD Shafman; Nancy J Tarbell; Peter M Mauch; Chikashi Ishioka; Daniel A Haber; Lisa Diller
Heterozygous germline ATM mutations do not contribute to radiation-associated malignancies after Hodgkin's disease.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(4):1259.
1998: Kim E Nichols; D P Harkin; S Levitz; michael krainer; KA Kolquist; C Genovese; A Bernard; M Ferguson; L Zuo; Eric Snyder; AJ Buckler; C Wise; J Ashley; Michael Lovett; M B Valentine; A Thomas Look; William Gerald; David E Housman; Daniel A Haber
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13765-70.
1998: MG FitzGerald; Deborah J Marsh; Doke C R Wahrer; D Bell; S Caron; KE Shannon; Chikashi Ishioka; Kurt J Isselbacher; Judy E Garber; Charis Eng; Daniel A Haber
Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer.
Oncogene 1998;17(6):727-31.
1998: KA Kolquist; Leif W Ellisen; CM Counter; Matthew Meyerson; L K Tan; Robert A. Weinberg; Daniel A Haber; William L Gerald
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.
Nature genetics 1998;19(2):182-6.
1998: Patricia Dahia; MG FitzGerald; X Zhang; Deborah J Marsh; Z Zheng; T Pietsch; A von Deimling; Frank G Haluska; Daniel A Haber; Charis Eng
A highly conserved processed PTEN pseudogene is located on chromosome band 9p21.
Oncogene 1998;16(18):2403-6.
1998: Daniel A Haber; Eric R Fearon
The promise of cancer genetics.
Lancet 1998;351 Suppl 2():SII1-8.
1998: Shyamala Maheswaran; C Englert; Sean B Lee; R M Ezzel; Jeffrey Settleman; Daniel A Haber
E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells.
Oncogene 1998;16(16):2041-50.
1998: Shyamala Maheswaran; C Englert; G Zheng; Sean B Lee; J Wong; D Paul Harkin; J Bean; Robert Ezzell; A J Garvin; Robert T McCluskey; James A DeCaprio; Daniel A Haber
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
Genes & development 1998;12(8):1108-20.
1998: CM Counter; Matthew Meyerson; Elinor Ng Eaton; Leif W Ellisen; SD Caddle; Daniel A Haber; Robert A. Weinberg
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase.
Oncogene 1998;16(9):1217-22.
1998: Leif W Ellisen; Daniel A Haber
Hereditary breast cancer.
Annual review of medicine 1998;49():425-36.
1997: Daniel A Haber
Splicing into senescence: the curious case of p16 and p19ARF.
Cell 1997;91(5):555-8.
1997: Sean B Lee; KA Kolquist; K Nichols; C Englert; Shyamala Maheswaran; Marc Ladanyi; William L Gerald; Daniel A Haber
The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour.
Nature genetics 1997;17(3):309-13.
1997: Matthew Meyerson; CM Counter; Elinor Ng Eaton; Leif W Ellisen; P Steiner; SD Caddle; L Ziaugra; RL Beijersbergen; M J Davidoff; Q Liu; S Bacchetti; Daniel A Haber; Robert A. Weinberg
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
Cell 1997;90(4):785-95.
1997: michael krainer; S Silva-Arrieta; MG FitzGerald; Akira Shimada; Chikashi Ishioka; Ryunosuke Kanamaru; Deborah MacDonald; H Unsal; D M Finkelstein; A Bowcock; Kurt J Isselbacher; Daniel A Haber
Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer.
The New England journal of medicine 1997;336(20):1416-21.
1997: C Englert; Shyamala Maheswaran; A J Garvin; Jordan A Kreidberg; Daniel A Haber
Induction of p21 by the Wilms' tumor suppressor gene WT1.
Cancer research 1997;57(8):1429-34.
1997: MG FitzGerald; J M Bean; S R Hegde; H Unsal; Deborah MacDonald; D Paul Harkin; D M Finkelstein; Kurt J Isselbacher; Daniel A Haber
Heterozygous ATM mutations do not contribute to early onset of breast cancer.
Nature genetics 1997;15(3):307-10.
1996: Ricky Johnstone; R H See; Stephen F Sells; J Wang; S Muthukkumar; C Englert; Daniel A Haber; Jonathan D Licht; S P Sugrue; T Roberts; Vivek M Rangnekar; Yang Shi
A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.
Molecular and cellular biology 1996;16(12):6945-56.
1996: Patricia N Tonin; Barbara Weber; Kenneth Offit; Fergus J. Couch; Timothy R Rebbeck; Susan L Neuhausen; A K Godwin; Mary Daly; J Wagner-Costalos; D Berman; G Grana; E Fox; Michael F Kane; R D Kolodner; michael krainer; Daniel A Haber; Jeffery Struewing; Ellen Warner; B Rosen; Caryn Lerman; Beth N Peshkin; Larry Norton; OM Serova; William D Foulkes; Judy E Garber
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families.
Nature medicine 1996;2(11):1179-83.
1996: Daniel A Haber; C Englert; Shyamala Maheswaran
Functional properties of WT1.
Medical and pediatric oncology 1996;27(5):453-5.
1996: MG FitzGerald; D Paul Harkin; S Silva-Arrieta; Deborah MacDonald; L C Lucchina; H Unsal; E O'Neill; James Koh; D M Finkelstein; Kurt J Isselbacher; A J Sober; Daniel A Haber
Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8541-5.
1996: MG FitzGerald; Deborah MacDonald; michael krainer; I Hoover; E O'Neil; H Unsal; S Silva-Arrieto; D M Finkelstein; P Beer-Romero; C Englert; D C Sgroi; B L Smith; J W Younger; Judy E Garber; R B Duda; K A Mayzel; Kurt J Isselbacher; S H Friend; Daniel A Haber
Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer.
The New England journal of medicine 1996;334(3):143-9.
1996: J Lamartine; K E Nichols; Luo Yin; michael krainer; F Heitzmann; A Bernard; S Gaudi; Gilbert M Lenoir; J L Sullivan; J E Ikeda; G Porta; David Schlessinger; Giovanni Romeo; Daniel A Haber; Bakary S Sylla; D Paul Harkin
Physical map and cosmid contig encompassing a new interstitial deletion of the X-linked lymphoproliferative syndrome region.
European journal of human genetics : EJHG 1996;4(6):342-51.
1995: C Englert; Marc Vidal; Shyamala Maheswaran; Y Ge; Robert Ezzell; Kurt J Isselbacher; Daniel A Haber
Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):11960-4.
1995: K E Nichols; Gian G Re; Y X Yan; A Julian Garvin; Daniel A Haber
WT1 induces expression of insulin-like growth factor 2 in Wilms' tumor cells.
Cancer research 1995;55(20):4540-3.
1995: C Englert; X Hou; Shyamala Maheswaran; P Bennett; C Ngwu; Gian G Re; A Julian Garvin; M R Rosner; Daniel A Haber
WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.
The EMBO journal 1995;14(19):4662-75.
1995: Shyamala Maheswaran; C Englert; P Bennett; G Heinrich; Daniel A Haber
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.
Genes & development 1995;9(17):2143-56.
1993: Daniel A Haber; S Park; Shyamala Maheswaran; C Englert; Gian G Re; Debra J Hazen-Martin; Donald A Sens; A Julian Garvin
WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.
Science (New York, N.Y.) 1993;262(5142):2057-9.
1993: S Park; A Bernard; K E Bove; Donald A Sens; Debra J Hazen-Martin; A Julian Garvin; Daniel A Haber
Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour.
Nature genetics 1993;5(4):363-7.
1993: S Park; Gail Tomlinson; P Nisen; Daniel A Haber
Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.
Cancer research 1993;53(20):4757-60.
1993: Shyamala Maheswaran; S Park; A Bernard; J F Morris; F J Rauscher; David E Hill; Daniel A Haber
Physical and functional interaction between WT1 and p53 proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5100-4.
1992: P N Baird; N Groves; Daniel A Haber; David E Housman; John Kenneth Cowell
Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.
Oncogene 1992;7(11):2141-9.
1992: Daniel A Haber; H T Timmers; J Pelletier; Phillip A Sharp; David E Housman
A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6010-4.
1992: Daniel A Haber; AJ Buckler
WT1: a novel tumor suppressor gene inactivated in Wilms' tumor.
The New biologist 1992;4(2):97-106.
1992: Daniel A Haber; David E Housman
The genetics of Wilms' tumor.
Advances in cancer research 1992;59():41-68.
1992: Daniel A Haber; David E Housman
Role of the WT1 gene in Wilms' tumour.
Cancer surveys 1992;12():105-17.
1991: Daniel A Haber; R L Sohn; AJ Buckler; J Pelletier; K M Call; David E Housman
Alternative splicing and genomic structure of the Wilms tumor gene WT1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(21):9618-22.
1991: J Pelletier; W Bruening; Frederick P Li; Daniel A Haber; Thomas M Glaser; David E Housman
WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.
Nature 1991;353(6343):431-4.
1991: J Pelletier; Martin Schalling; AJ Buckler; A Rogers; Daniel A Haber; D Housman
Expression of the Wilms' tumor gene WT1 in the murine urogenital system.
Genes & development 1991;5(8):1345-56.
1991: AJ Buckler; D D Chang; Sharon L Graw; J David Brook; Daniel A Haber; Phillip A Sharp; David E Housman
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):4005-9.
1991: Vicki Huff; H Miwa; Daniel A Haber; K M Call; D Housman; Louise C Strong; Grady F Saunders
Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT.
American journal of human genetics 1991;48(5):997-1003.
1991: John Kenneth Cowell; R B Wadey; Daniel A Haber; K M Call; David E Housman; Jon Pritchard
Structural rearrangements of the WT1 gene in Wilms' tumour cells.
Oncogene 1991;6(4):595-9.
1991: AJ Buckler; J Pelletier; Daniel A Haber; Thomas M Glaser; David E Housman
Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development.
Molecular and cellular biology 1991;11(3):1707-12.
1991: Daniel A Haber; David E Housman
Rate-limiting steps: the genetics of pediatric cancers.
Cell 1991;64(1):5-8.
1990: Daniel A Haber; AJ Buckler; Thomas M Glaser; K M Call; J Pelletier; R L Sohn; E C Douglass; David E Housman
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.
Cell 1990;61(7):1257-69.
1990: K M Call; Thomas M Glaser; C Y Ito; AJ Buckler; J Pelletier; Daniel A Haber; E A Rose; A Kral; Herman Yeger; W H Lewis
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.
Cell 1990;60(3):509-20.