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Salima Hacein-Bey-Abina

Research Profile

Procedures

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Gene Transfer Techniques

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Publications

TOP 3
Marina Cavazzana-Calvo; Alain Fischer; Salima Hacein-Bey-Abina; Alessandro Aiuti
Gene therapy for primary immunodeficiencies: Part 1.
Fabien Touzot; Virginie Verkarre; Stéphane Blanche; Marina Cavazzana-Calvo; Anne Crucis-Armengaud; Liliane Dal Cortivo; Pierre Frange; Salima Hacein-Bey-Abina; Sébastien Héritier; Sophie Kaltenbach; Annick Lim; Despina Moshous; Capucine Picard; Alain Fischer
Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl.
J C M van der Loo; David A Williams; M Cavazzana-Calvo; E Grassman; Salima Hacein-Bey-Abina; T Higashimoto; D L Nordling; Lilith Reeves; Axel Schambach; W P Swaney; A Terwilliger; A J Thrasher; P Malik
Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency.

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All Publications

2012: Marina Cavazzana-Calvo; Alain Fischer; Salima Hacein-Bey-Abina; Alessandro Aiuti
Gene therapy for primary immunodeficiencies: Part 1.
Current opinion in immunology 2012;24(5):580-4.
2012: Fabien Touzot; Virginie Verkarre; Stéphane Blanche; Marina Cavazzana-Calvo; Anne Crucis-Armengaud; Liliane Dal Cortivo; Pierre Frange; Salima Hacein-Bey-Abina; Sébastien Héritier; Sophie Kaltenbach; Annick Lim; Despina Moshous; Capucine Picard; Alain Fischer
Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl.
Blood 2012;120(9):1957-9.
2012: J C M van der Loo; David A Williams; M Cavazzana-Calvo; E Grassman; Salima Hacein-Bey-Abina; T Higashimoto; D L Nordling; Lilith Reeves; Axel Schambach; W P Swaney; A Terwilliger; A J Thrasher; P Malik
Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency.
Gene therapy 2012;19(8):872-6.
2012: Nathalie Cartier; Marina Cavazzana-Calvo; Alain Fischer; Salima Hacein-Bey-Abina; Manfred Schmidt; Christof von Kalle; Cynthia C Bartholomae; Pierre Bougnères; Patrick Aubourg
Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy.
Methods in enzymology 2012;507():187-98.
2012: Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
Strategies for retrovirus-based correction of severe, combined immunodeficiency (SCID).
Methods in enzymology 2012;507():15-27.
2011: Annette Deichmann; Cynthia E Dunbar; Alain Fischer; Richard Gabriel; H Bobby Gaspar; Hanno Glimm; Manuel Grez; Salima Hacein-Bey-Abina; Dieter Hoelzer; Steven J Howe; Fulvio Mavilio; Marion G Ott; Anna Paruzynski; Manfred Schmidt; Kerstin Schwarzwaelder; Reinhard Seger; Adrian J Thrasher; Monique M A Verstegen; Christof von Kalle; Ulrich Abel; Alessandro Aiuti; Anne Arens; Cynthia C Bartholomae; Christopher Baum; Martijn Brugman; Barbara Cassani; Claudia Cattoglio; Marina Cavazzana-Calvo; Gerard Wagemaker
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):2031-9.
2011: Karin Pike-Overzet; M Rodijk; A Schambach; Adrian J Thrasher; J J M van Dongen; F Zhang; M R M Baert; Christopher Baum; R G M Bredius; M Cavazzana-Calvo; G J A Driessen; Salima Hacein-Bey-Abina; Rob Hoeben; C Lagresle-Peyrou; Arjan C Lankester; Yuk Yin Ng; Frank Staal
Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Leukemia 2011;25(9):1471-83.
2011: Julia Hauer; Sven Kracker; Marc Lelorc'h; Estelle Morillon; Charles G Mullighan; Serge Romana; Daniela Tiedau; Gary Wang; Arndt Borkhardt; Amine Boudil; Nicole Brousse; Julie Bruneau; Frederic D Bushmann; Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.
Blood 2011;118(3):544-53.
2011: Emmanuelle M Six; Fatine Benjelloun; Alexandrine Garrigue; Delphine Bonhomme; Estelle Morillon; Julien Rouiller; Laure Cacavelli; Johanna Blondeau; Kheira Beldjord; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo; Isabelle André-Schmutz
Cytokines and culture medium have a major impact on human in vitro T-cell differentiation.
Blood cells, molecules & diseases 2011;47(1):72-8.
2011: Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
Gene therapy for primary adaptive immune deficiencies.
The Journal of allergy and clinical immunology 2011;127(6):1356-9.
2011: Marina Cavazzana-Calvo; Alain Fischer; Frederic D Bushman; Emmanuel Payen; Salima Hacein-Bey-Abina; Philippe Leboulch
Is normal hematopoiesis maintained solely by long-term multipotent stem cells?
Blood 2011;117(17):4420-4.
2011: Alain Fischer; Salima Hacein-Bey-Abina; M Cavazzana-Calvo
Gene therapy for primary immunodeficiencies.
Hematology/oncology clinics of North America 2011;25(1):89-100.
2010: Sheng Zhou; Disha Mody; Suk See DeRavin; Julia Hauer; Taihe Lu; Zhijun Ma; Salima Hacein-Bey-Abina; John T Gray; Michael R Greene; Marina Cavazzana-Calvo; Harry L Malech; Brian P Sorrentino
A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.
Blood 2010;116(6):900-8.
2010: Salima Hacein-Bey-Abina; Julia Hauer; Annick Lim; Capucine Picard; Gary P Wang; Charles C Berry; Chantal Martinache; Frédéric Rieux-Laucat; Sylvain Latour; Bernd H Belohradsky; Lily Leiva; Ricardo Sorensen; Marianne Debré; Jean-Laurent Casanova; Stéphane Blanche; Anne Durandy; Frederic D Bushman; Alain Fischer; Marina Cavazzana-Calvo
Efficacy of gene therapy for X-linked severe combined immunodeficiency.
The New England journal of medicine 2010;363(4):355-64.
2010: Christian Reimann; Liliane Dal Cortivo; Salima Hacein-Bey-Abina; Alain Fischer; Isabelle André-Schmutz; Marina Cavazzana-Calvo
Advances in adoptive immunotherapy to accelerate T-cellular immune reconstitution after HLA-incompatible hematopoietic stem cell transplantation.
Immunotherapy 2010;2(4):481-96.
2010: Gary P Wang; Charles C Berry; Nirav Malani; Philippe Leboulch; Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo; Frederic D Bushman
Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial.
Blood 2010;115(22):4356-66.
2010: Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
20 years of gene therapy for SCID.
Nature immunology 2010;11(6):457-60.
2010: Alain Fischer; Salima Hacein-Bey-Abina; M Cavazzana-Calvo; M Cavazanna-Calvo
Gene therapy for primary immunodeficiencies.
Immunology and allergy clinics of North America 2010;30(2):237-48.
2010: Nathalie Cartier; Salima Hacein-Bey-Abina; Christof von Kalle; Pierre Bougnères; Alain Fischer; Marina Cavazzana-Calvo; Patrick Aubourg
[Gene therapy of x-linked adrenoleukodystrophy using hematopoietic stem cells and a lentiviral vector].
Bulletin de l'Académie nationale de médecine 2010;194(2):255-64; discussion 264-8.
2010: Marina Cavazzana-Calvo; Salima Hacein-Bey-Abina; Alain Fischer
[Ten years of gene therapy: thoughts and perspectives].
Médecine sciences : M/S 2010;26(2):115-8.
2009: Nathalie Cartier; Salima Hacein-Bey-Abina; Cynthia C Bartholomae; Gabor Veres; Manfred Schmidt; Ina Kutschera; Michel Vidaud; Ulrich Abel; Liliane Dal Cortivo; Laure Caccavelli; Nizar Mahlaoui; veronique kiermer; Denice Mittelstaedt; Céline Bellesme; Najiba Lahlou; François Lefrère; Stéphane Blanche; Muriel Audit; Emmanuel Payen; Philippe Leboulch; Bruno l'Homme; Pierre Bougnères; Christof von Kalle; Alain Fischer; Marina Cavazzana-Calvo; Patrick Aubourg
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.
Science (New York, N.Y.) 2009;326(5954):818-23.
2009: Marina Cavazzana-Calvo; Isabelle André-Schmutz; Liliane Dal Cortivo; Bénédicte Neven; Salima Hacein-Bey-Abina; Alain Fischer
Immune reconstitution after haematopoietic stem cell transplantation: obstacles and anticipated progress.
Current opinion in immunology 2009;21(5):544-8.
2009: Bénédicte Neven; Sandrine Leroy; Hélène Decaluwe; Françoise Le Deist; Capucine Picard; Despina Moshous; Nizar Mahlaoui; Marianne Debré; Jean-Laurent Casanova; Liliane Dal Cortivo; Yoann Madec; Salima Hacein-Bey-Abina; Geneviève de Saint Basile; Jean-Pierre De Villartay; Stéphane Blanche; Marina Cavazzana-Calvo; Alain Fischer
Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency.
Blood 2009;113(17):4114-24.
2008: Salima Hacein-Bey-Abina; Alexandrine Garrigue; Gary P Wang; Jean Soulier; Annick Lim; Estelle Morillon; Emmanuelle Clappier; Laure Caccavelli; Eric Delabesse; Kheira Beldjord; Vahid Asnafi; Elizabeth Macintyre; Liliane Dal Cortivo; Isabelle Radford; Nicole Brousse; François Sigaux; Despina Moshous; Julia Hauer; Arndt Borkhardt; Bernd H Belohradsky; Uwe Wintergerst; Maria C Velez; Lily Leiva; Ricardo Sorensen; Nicolas Wulffraat; Stéphane Blanche; Frederic D Bushman; Alain Fischer; Marina Cavazzana-Calvo
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.
The Journal of clinical investigation 2008;118(9):3132-42.
2008: Gary P Wang; Alexandrine Garrigue; Angela Ciuffi; Keshet Ronen; Jeremy Leipzig; Charles Berry; Chantal Lagresle-Peyrou; Fatine Benjelloun; Salima Hacein-Bey-Abina; Alain Fischer; Marina Cavazzana-Calvo; Frederic D Bushman
DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer.
Nucleic acids research 2008;36(9):e49.
2008: Chantal Lagresle-Peyrou; Fatine Benjelloun; Christophe Hue; Isabelle Andre-Schmutz; Delphine Bonhomme; Monique Forveille; Kheira Beldjord; Salima Hacein-Bey-Abina; Jean-Pierre De Villartay; Pierre Charneau; Anne Durandy; Alain Fischer; Marina Cavazzana-Calvo
Restoration of human B-cell differentiation into NOD-SCID mice engrafted with gene-corrected CD34+ cells isolated from Artemis or RAG1-deficient patients.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):396-403.
2007: Marina Cavazzana-Calvo; Liliane Dal Cortivo; Isabelle André-Schmutz; Salima Hacein-Bey-Abina; Alain Fischer
[Cell therapy for inherited diseases of the hematopoietic system].
Comptes rendus biologies 2007;330(6-7):538-42.
2007: Marina Cavazzana-Calvo; Frédérique Carlier; Françoise Le Deist; Estelle Morillon; Pierre Taupin; David Gautier; Isabelle Radford-Weiss; Sophie Caillat-Zucman; Bénédicte Neven; Stéphane Blanche; remi cheynier; Alain Fischer; Salima Hacein-Bey-Abina
Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell-immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype.
Blood 2007;109(10):4575-81.
2007: Ulrich Abel; Annette Deichmann; Cynthia Bartholomae; Kerstin Schwarzwaelder; Hanno Glimm; Steven J Howe; Adrian J Thrasher; Alexandrine Garrigue; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo; Alain Fischer; Dirk Jaeger; Christof von Kalle; Manfred Schmidt
Real-time definition of non-randomness in the distribution of genomic events.
PloS one 2007;2(6):e570.
2006: A C Bester; Michal Schwartz; Manfred Schmidt; Alexandrine Garrigue; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo; Neta Ben-Porat; Christof von Kalle; Alain Fischer; Batsheva Kerem
Fragile sites are preferential targets for integrations of MLV vectors in gene therapy.
Gene therapy 2006;13(13):1057-9.
2006: Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
Gene therapy of metabolic diseases.
Journal of inherited metabolic disease 2006;29(2-3):409-12.
2005: Adrian J Thrasher; Salima Hacein-Bey-Abina; H Bobby Gaspar; Stéphane Blanche; E Graham Davies; Kathryn L Parsley; Kimberly C Gilmour; Douglas King; Steven J Howe; Joanna Sinclair; Christophe Hue; Frédérique Carlier; Christof von Kalle; Geneviève de Saint Basile; Françoise Le Deist; Alain Fischer; Marina Cavazzana-Calvo
Failure of SCID-X1 gene therapy in older patients.
Blood 2005;105(11):4255-7.
2005: Samantha L Ginn; Julie A Curtin; Belinda Kramer; Christine M Smyth; Melanie Wong; Alyson Kakakios; Geoffrey B McCowage; Debbie Watson; Stephen I Alexander; Margot Latham; Sharon C Cunningham; Maolin Zheng; Linda Hobson; Peter B Rowe; Alain Fischer; Marina Cavazzana-Calvo; Salima Hacein-Bey-Abina; Ian E Alexander
Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia.
The Medical journal of Australia 2005;182(9):458-63.
2005: Alain Fischer; Salima Hacein-Bey-Abina; Chantal Lagresle; Alexandrine Garrigue; Marina Cavazana-Calvo
[Gene therapy of severe combined immunodeficiency disease: proof of principle of efficiency and safety issues. Gene therapy, primary immunodeficiencies, retrovirus, lentivirus, genome].
Bulletin de l'Académie nationale de médecine 2005;189(5):779-85; discussion 786-8.
2005: Manfred Schmidt; Salima Hacein-Bey-Abina; Manuela Wissler; Frédérique Carlier; Annick Lim; Claudia Prinz; Hanno Glimm; Isabelle Andre-Schmutz; Christophe Hue; Alexandrine Garrigue; Françoise Le Deist; Chantal Lagresle; Alain Fischer; Marina Cavazzana-Calvo; Christof von Kalle
Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial.
Blood 2005;105(7):2699-706.
2005: Alain Fischer; Françoise Le Deist; Salima Hacein-Bey-Abina; Isabelle André-Schmutz; Geneviève de Saint Basile; Jean-Pierre De Villartay; Marina Cavazzana-Calvo
Severe combined immunodeficiency. A model disease for molecular immunology and therapy.
Immunological reviews 2005;203():98-109.
2005: Marina Cavazzana-Calvo; Chantal Lagresle; Salima Hacein-Bey-Abina; Alain Fischer
Gene therapy for severe combined immunodeficiency.
Annual review of medicine 2005;56():585-602.
2004: Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
Gene therapy for immunodeficiency diseases.
Seminars in hematology 2004;41(4):272-8.
2004: Sophie Caillat-Zucman; Françoise Le Deist; Elie Haddad; monique Gannagé; Liliane Dal Cortivo; Nada Jabado; Salima Hacein-Bey-Abina; Stéphane Blanche; Jean-Laurent Casanova; A Fischer; Marina Cavazzana-Calvo
Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases: a single-center comparative analysis of genoidentical, haploidentical or unrelated donors.
Bone marrow transplantation 2004;33(11):1089-95.
2004: Marina Cavazzana-Calvo; Chantal Lagresle; Isabelle André-Schmutz; Salima Hacein-Bey-Abina
[The bone marrow: a reserve of stem cells able to repair various tissues?].
Annales de biologie clinique 2004;62(2):131-8.
2004: Salima Hacein-Bey-Abina
[Gene therapy, where does it stand today].
Le Journal médical libanais. The Lebanese medical journal 2004;52(1):32.
2004: Alain Fischer; Salima Hacein-Bey-Abina; Marina Cavazzana-Calvo
[Gene therapy of children with X-linked severe combined immune deficiency: efficiency and complications].
Médecine sciences : M/S 2004;20(1):115-7.
2003: Salima Hacein-Bey-Abina; Christof von Kalle; Manfred Schmidt; Françoise Le Deist; Nico M Wulffraat; Elisabeth McIntyre; Isabelle Radford; Jean-Luc Villeval; Christopher C Fraser; Marina Cavazzana-Calvo; Alain Fischer
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.
The New England journal of medicine 2003;348(3):255-6.
2003: Salima Hacein-Bey-Abina; Geneviève de Saint Basile; Marina Cavazzana-Calvo
Gene therapy of X-linked severe combined immunodeficiency.
Methods in molecular biology (Clifton, N.J.) 2003;215():247-59.
2002: Marina Cavazzana-Calvo; Salima Hacein-Bey-Abina; Alain Fischer
Gene therapy of X-linked severe combined immunodeficiency.
Current opinion in allergy and clinical immunology 2002;2(6):507-9.
2002: Salima Hacein-Bey-Abina; Alain Fischer; Marina Cavazzana-Calvo
Gene therapy of X-linked severe combined immunodeficiency.
International journal of hematology 2002;76(4):295-8.
2002: Isabelle André-Schmutz; Françoise Le Deist; Salima Hacein-Bey-Abina; Ellen S Vitetta; John Schindler; Gaëlle Chedeville; Etienne Vilmer; Alain Fischer; Marina Cavazzana-Calvo
Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study.
Lancet 2002;360(9327):130-7.
2002: Salima Hacein-Bey-Abina; Françoise Le Deist; Frédérique Carlier; Cécile Bouneaud; Christophe Hue; Jean-Pierre De Villartay; Adrian J Thrasher; Nico M Wulffraat; Ricardo U Sorensen; Sophie Dupuis-Girod; Alain Fischer; E Graham Davies; Wietse Kuis; Lilly Leiva; Marina Cavazzana-Calvo
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
The New England journal of medicine 2002;346(16):1185-93.
2002: Marina Cavazzana-Calvo; Isabelle André-Schmutz; Salima Hacein-Bey-Abina; Danielle Bensoussan; Françoise Le Deist; Alain Fischer
Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantation.
Seminars in hematology 2002;39(1):32-40.
2001: Marina Cavazzana-Calvo; Salima Hacein-Bey-Abina
Correction of genetic blood defects by gene transfer.
Current opinion in hematology 2001;8(6):360-7.