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Tilman Hackeng

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Physiology

Blood Coagulation

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TOP 3
Kristien Winckers; Hugo ten Cate; Tilman M Hackeng
The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis.
Martijn Wolters; Tilman M Hackeng; Marianne E Kooi; Seyede G Mohades; Mark J Post; Walter H Backes
Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy.
S Peraramelli; Jan Rosing; Friedrich Scheiflinger; S Thomassen; Tilman M Hackeng; R Hartmann; A Heinzmann; Michael Dockal
Direct inhibition of factor VIIa by TFPI and TFPI constructs.

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All Publications

2013: Kristien Winckers; Hugo ten Cate; Tilman M Hackeng
The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis.
Blood reviews 2013;27(3):119-32.
2013: Martijn Wolters; Tilman M Hackeng; Marianne E Kooi; Seyede G Mohades; Mark J Post; Walter H Backes
Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy.
Investigative radiology 2013;48(5):341-50.
2013: S Peraramelli; Jan Rosing; Friedrich Scheiflinger; S Thomassen; Tilman M Hackeng; R Hartmann; A Heinzmann; Michael Dockal
Direct inhibition of factor VIIa by TFPI and TFPI constructs.
Journal of thrombosis and haemostasis : JTH 2013;11(4):704-14.
2013: Timo Rademakers; Judith Sluimer; Erik A L Biessen; Mat J A P Daemen; Kim Douma; Tilman M Hackeng; Sylvia Heeneman; Mark J Post; Marc A M J van Zandvoort
Plaque-associated vasa vasorum in aged apolipoprotein E-deficient mice exhibit proatherogenic functional features in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(2):249-56.
2013: Julian I. Borissoff; Mat J A P Daemen; Jay L Degen; Charles T Esmon; Tilman M Hackeng; Karly Hamulyák; Sylvia Heeneman; Peter Leenders; Sarah T B G Loubele; Jeroen J T Otten; Oliver Soehnlein; Henri M H Spronk; René Van Oerle; Joanne van Ryn; Hartmut Weiler; Erik A L Biessen; Hugo ten Cate
Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
PloS one 2013;8(2):e55784.
2012: Ties A Mulders; Coen D A Stehouwer; Christel van der Donk; Isabel Ferreira; Tilman M Hackeng; Marijn Hameeteman; Abraham A Kroon; Lisbeth F A Maurissen; Zainna Meyer; Sara-Joan Pinto-Sietsma
A positive family history for premature cardiovascular disease identifies patients prone to recurrent arterial thrombotic events.
European journal of preventive cardiology 2012;19(6):1465-73.
2012: Pieter Van de Vijver; John H Griffin; Rory R Koenen; Liesbeth Scheer; Martin Schmitt; Leon J Schurgers; Dennis Suylen; M Christella L G D Thomassen; Tilman M Hackeng
Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S.
Journal of the American Chemical Society 2012;134(47):19318-21.
2012: Matthijs G Compeer; Tilman M Hackeng; Dennis P L Suylen; Jo G R De Mey
Endothelin-1 and -2: two amino acids matter.
Life sciences 2012;91(13-14):607-12.
2012: K Winckers; K C M M Beekers; P Erkens; Karly Hamulyák; Hugo ten Cate; A J Ten Cate-Hoek; Tilman M Hackeng
Impaired tissue factor pathway inhibitor function is associated with recurrent venous thromboembolism in patients with first unprovoked deep venous thrombosis.
Journal of thrombosis and haemostasis : JTH 2012;10(10):2208-11.
2012: Pieter Van de Vijver; Arjan Griffioen; Liesbeth Scheer; Judy van Beijnum; Tilman M Hackeng
Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain.
Chemical communications (Cambridge, England) 2012;48(75):9403-5.
2012: Sameera Peraramelli; Jan Rosing; Dennis P L Suylen; Tilman M Hackeng
The Kunitz 1 and Kunitz 3 domains of tissue factor pathway inhibitor are required for efficient inhibition of factor Xa.
Thrombosis and haemostasis 2012;108(2):266-76.
2012: Martijn L L Chatrou; Tilman M Hackeng; Chris P Reutelingsperger; Kristien Winckers; Leon J Schurgers
Vascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonists.
Blood reviews 2012;26(4):155-66.
2012: Sameera Peraramelli; Jan Rosing; Tilman M Hackeng
TFPI-dependent activities of protein S.
Thrombosis research 2012;129 Suppl 2():S23-6.
2012: J Grommes; Tilman M Hackeng; Michael Jacobs; Rory R Koenen; Wolfgang M Kuebler; Philipp Markart; Matthias Mörgelin; Klaus T Preissner; Philipp von Hundelshausen; Sarawuth Wantha; Christian Weber; Malgorzata Wygrecka; Jean-Eric Alard; Maik Drechsler; Oliver Soehnlein
Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.
American journal of respiratory and critical care medicine 2012;185(6):628-36.
2011: K Winckers; A Algra; Elisabetta Castoldi; C Duckers; Tilman M Hackeng; L F Maurissen; B Siegerink; Henri M H Spronk; Guido Tans; Hugo ten Cate; Frits R Rosendaal
Increased tissue factor pathway inhibitor activity is associated with myocardial infarction in young women: results from the RATIO study.
Journal of thrombosis and haemostasis : JTH 2011;9(11):2243-50.
2011: Hilde Laeremans; Harry C J Ottenheijm; Jos F M Smits; Victor L J L Thijssen; Marc A M J van Zandvoort; Tilman M Hackeng; Ben J A Janssen; W Matthijs Blankesteijn
Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction.
Circulation 2011;124(15):1626-35.
2011: Oliver Soehnlein; Marc A M J van Zandvoort; Santosh Vijayan; Sarawuth Wantha; Stefan Weinandy; Alma Zernecke; Birgitta Agerberth; Yvonne Döring; Maik Drechsler; Richard L Gallo; Thomas Gries; Tilman M Hackeng; Stefan Jockenhoevel; Doris Klee; Elisa A Liehn; Sebastian F Mause; remco TA megens; Martin Möller; Christine T Pham; Fabian Schreiber; Sakine Simsekyilmaz; Ralf Smeets; Christian Weber
Neutrophil-derived cathelicidin protects from neointimal hyperplasia.
Science translational medicine 2011;3(103):103ra98.
2011: Peter Panizzi; Mikael J Pittet; Olaf Schneewind; Filip K Swirski; Peter Waterman; Elena Aikawa; Paul E Bock; Jose-Luiz Figueiredo; Pablo Fuentes-Prior; Tilman M Hackeng; Yoshiko Iwamoto; Edmund Keliher; Heather K Kroh; Florian Leuschner; Ashoka A Maddur; Brett Marinelli; Matthias Nahrendorf; Jennifer Panizzi; Ralph Weissleder
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.
Nature medicine 2011;17(9):1142-6.
2011: Michal S Shoshan; Deborah E Shalev; Wencke Adriaens; Maarten Merkx; Tilman M Hackeng; Edit Y Tshuva
NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine.
Chemical communications (Cambridge, England) 2011;47(22):6407-9.
2011: Maartje M C Bastings; Brett A Helms; Ingrid van Baal; Tilman M Hackeng; Maarten Merkx; EW Meijer
From phage display to dendrimer display: insights into multivalent binding.
Journal of the American Chemical Society 2011;133(17):6636-41.
2011: A Sarabi; B K Kramp; Maik Drechsler; Tilman M Hackeng; O Soehnlein; Christian Weber; Rory R Koenen; Philipp von Hundelshausen
CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment.
Journal of thrombosis and haemostasis : JTH 2011;9(1):209-19.
2010: Elisabetta Castoldi; Lisbeth F A Maurissen; Daniela Tormene; Luca Spiezia; Sabrina Gavasso; Claudia Radu; Tilman M Hackeng; Jan Rosing; Paolo Simioni
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency.
Haematologica 2010;95(9):1563-71.
2010: Julian I. Borissoff; Sylvia Heeneman; Evren Kilinç; Peter Kassák; René Van Oerle; Kristien Winckers; José W P Govers-Riemslag; Karly Hamulyák; Tilman M Hackeng; Mat J A P Daemen; Hugo ten Cate; Henri M H Spronk
Early atherosclerosis exhibits an enhanced procoagulant state.
Circulation 2010;122(8):821-30.
2010: Victor L Thijssen; Batya Barkan; Hiroki Shoji; Ingrid M Aries; Véronique Mathieu; Louise Deltour; Tilman M Hackeng; Robert Kiss; Yoel Kloog; Françoise Poirier; Arjan W Griffioen
Tumor cells secrete galectin-1 to enhance endothelial cell activity.
Cancer research 2010;70(15):6216-24.
2010: Marlies Oostendorp; Kim Douma; Tilman M Hackeng; Mark J Post; Marc A M J van Zandvoort; Walter H Backes
Gadolinium-labeled quantum dots for molecular magnetic resonance imaging: R1 versus R2 mapping.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2010;64(1):291-8.
2010: Elisabetta Castoldi; Lisbeth F A Maurissen; Daniela Tormene; Luca Spiezia; Sabrina Gavasso; Claudia Radu; Tilman M Hackeng; Jan Rosing; Paolo Simioni
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from mixed type I/III families.
Haematologica 2010;():.
2010: L F A Maurissen; Elisabetta Castoldi; Paolo Simioni; Jan Rosing; Tilman M Hackeng
Thrombin generation-based assays to measure the activity of the TFPI-protein S pathway in plasma from normal and protein S-deficient individuals.
Journal of thrombosis and haemostasis : JTH 2010;8(4):750-8.
2010: Marlies Oostendorp; Kim Douma; Allard Wagenaar; Jos M G M Slenter; Tilman M Hackeng; Marc A M J van Zandvoort; Mark J Post; Walter H Backes
Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction.
Circulation 2010;121(6):775-83.
2010: Elisabetta Castoldi; P Simioni; D Tormene; Jan Rosing; Tilman M Hackeng
Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma.
Journal of thrombosis and haemostasis : JTH 2010;8(2):294-300.
2010: Pieter Van de Vijver; Dennis Suylen; Anouk Dirksen; Philip E Dawson; Tilman M Hackeng
Nepsilon-(thiaprolyl)-lysine as a handle for site-specific protein conjugation.
Biopolymers 2010;94(4):465-74.
2010: Merlijn Meens; Matthijs G Compeer; Tilman M Hackeng; Marc A M J van Zandvoort; Ben J A Janssen; Jo De Mey
Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ET(A)-receptor complexes.
PloS one 2010;5(6):e10917.
2010: Marlies Oostendorp; Kim Douma; Tilman M Hackeng; Marc A M J van Zandvoort; Mark J Post; Walter H Backes
Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging.
Contrast media & molecular imaging 2010;5(1):9-17.
2009: Tilman M Hackeng; Jan Rosing
Protein S as cofactor for TFPI.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(12):2015-20.
2009: Lucie Khemtémourian; Gemma Lahoz Casarramona; Dennis P L Suylen; Tilman M Hackeng; Johannes D Meeldijk; Ben de Kruijff; Jo W M Höppener; J Antoinette Killian
Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro.
Biochemistry 2009;48(46):10918-25.
2009: François Saller; Anne C Brisset; Svetlana N Tchaikovski; Monica Azevedo; Roman Chrast; José A Fernández; Marc Schapira; Tilman M Hackeng; John H Griffin; Anne Angelillo-Scherrer
Generation and phenotypic analysis of protein S-deficient mice.
Blood 2009;114(11):2307-14.
2009: Edith H M Lempens; Ingrid van Baal; Joost L J van Dongen; Tilman M Hackeng; Maarten Merkx; EW Meijer
Noncovalent synthesis of protein dendrimers.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(35):8760-7.
2009: Robbert-Jan J H M Miserus; M Veronica Herías; Lenneke Prinzen; Marc B I Lobbes; Robert-Jan Van Suylen; Anouk Dirksen; Tilman M Hackeng; Johan W M Heemskerk; Jos M A van Engelshoven; Mat J A P Daemen; Marc A M J van Zandvoort; Sylvia Heeneman; Marianne Eline Kooi
Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent.
JACC. Cardiovascular imaging 2009;2(8):987-96.
2009: Tilman M Hackeng; L F A Maurissen; Elisabetta Castoldi; Jan Rosing
Regulation of TFPI function by protein S.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():165-8.
2009: Rory R Koenen; Jessica Pruessmeyer; Oliver Soehnlein; Line Fraemohs; Alma Zernecke; Nicole Schwarz; Karina Reiss; Alisina Sarabi; Lennart Lindbom; Tilman M Hackeng; Christian Weber; Andreas Ludwig
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Blood 2009;113(19):4799-809.
2009: Kim Douma; Lenneke Prinzen; Dick W Slaaf; Chris P M Reutelingsperger; Erik A L Biessen; Tilman M Hackeng; Mark J Post; Marc A M J van Zandvoort
Nanoparticles for optical molecular imaging of atherosclerosis.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(5):544-57.
2009: Rory R Koenen; Philipp von Hundelshausen; Irina V Nesmelova; Alma Zernecke; Elisa A Liehn; Alisina Sarabi; Birgit K Kramp; Anna Maria Piccinini; Søren R Paludan; M Anna Kowalska; Andreas J Kungl; Tilman M Hackeng; Kevin H Mayo; Christian Weber
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.
Nature medicine 2009;15(1):97-103.
2008: Subramanian Yegneswaran; Tilman M Hackeng; Philip E Dawson; John H Griffin
The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa.
The Journal of biological chemistry 2008;283(48):33046-52.
2008: Marlies Oostendorp; Kim Douma; Tilman M Hackeng; Anouk Dirksen; Mark J Post; Marc A M J van Zandvoort; Walter H Backes
Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots.
Cancer research 2008;68(18):7676-83.
2008: Coen Maas; Bettina Schiks; Remo D Strangi; Tilman M Hackeng; Bonno N Bouma; Martijn F B G Gebbink; Barend Bouma
Identification of fibronectin type I domains as amyloid-binding modules on tissue-type plasminogen activator and three homologs.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2008;15(3):166-80.
2008: Elisabetta Castoldi; Tilman M Hackeng
Regulation of coagulation by protein S.
Current opinion in hematology 2008;15(5):529-36.
2008: Kitty B J M Cleutjens; Birgit C G Faber; Mat Rousch; Ruben van Doorn; Tilman M Hackeng; Cornelis Vink; Piet Geusens; Hugo ten Cate; Johannes Waltenberger; Vadim Tchaikovski; Marc Lobbes; Veerle Somers; Anneke Sijbers; Darcey Black; Peter J E H M Kitslaar; Mat J A P Daemen
Noninvasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profiling.
The Journal of clinical investigation 2008;118(8):2979-85.
2008: Lisbeth F A Maurissen; M Christella L G D Thomassen; Gerry A F Nicolaes; Björn Dahlbäck; Guido Tans; Jan Rosing; Tilman M Hackeng
Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.
Blood 2008;111(6):3034-41.
2008: Jan Rosing; L F A Maurissen; S N Tchaikovski; Guido Tans; Tilman M Hackeng
Protein S is a cofactor for tissue factor pathway inhibitor.
Thrombosis research 2008;122 Suppl 1():S60-3.
2008: Ellen C M Cranenburg; Cees Vermeer; Ralf Koos; Marie-Louise Boumans; Tilman M Hackeng; Freek G Bouwman; Martijn Kwaijtaal; Vincent M Brandenburg; Markus Ketteler; Leon J Schurgers
The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.
Journal of vascular research 2008;45(5):427-36.
2007: Leon J Schurgers; Henri M H Spronk; J N Skepper; Tilman M Hackeng; C M Shanahan; Cees Vermeer; P L Weissberg; Diane Proudfoot
Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification.
Journal of thrombosis and haemostasis : JTH 2007;5(12):2503-11.
2007: Hugo Aerts; Ludwig Dubois; Tilman M Hackeng; Roel Straathof; Roland K Chiu; Natasja Lieuwes; Barry Jutten; Sherry A Weppler; Guido Lammering; Bradly G Wouters; Philippe Lambin
Development and evaluation of a cetuximab-based imaging probe to target EGFR and EGFRvIII.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007;83(3):326-32.
2007: Lenneke Prinzen; Robbert-Jan J H M Miserus; Anouk Dirksen; Tilman M Hackeng; Niko Deckers; Nicole J Bitsch; remco TA megens; Kim Douma; Johan W M Heemskerk; M Eline Kooi; Peter M Frederik; Dick W Slaaf; Marc A M J van Zandvoort; Chris P M Reutelingsperger
Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dots.
Nano letters 2007;7(1):93-100.
2006: Anouk Dirksen; Sjoerd Dirksen; Tilman M Hackeng; Philip E Dawson
Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry.
Journal of the American Chemical Society 2006;128(49):15602-3.
2006: Alexandra Buehler; Marc A M J van Zandvoort; Bram J Stelt; Tilman M Hackeng; Bianca H G J Schrans-Stassen; Abdelkader Bennaghmouch; Leo Hofstra; Jack P M Cleutjens; Adriaan Duijvestijn; Mirjam B Smeets; Dominique P V de Kleijn; Mark J Post; Ebo D de Muinck
cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2681-7.
2006: Anouk Dirksen; Tilman M Hackeng; Philip E Dawson
Nucleophilic catalysis of oxime ligation.
Angewandte Chemie (International ed. in English) 2006;45(45):7581-4.
2006: Gerry A F Nicolaes; Tilman M Hackeng; Kenneth Segers; Jan Rosing
A structural model of the SHBG domain of human variant protein S Heerlen.
Thrombosis and haemostasis 2006;96(4):538-40.
2006: Anouk Dirksen; EW Meijer; Wencke Adriaens; Tilman M Hackeng
Strategy for the synthesis of multivalent peptide-based nonsymmetric dendrimers by native chemical ligation.
Chemical communications (Cambridge, England) 2006;(15):1667-9.
2006: Tilman M Hackeng; Kristin M Seré; Guido Tans; Jan Rosing
Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3106-11.
2006: Kristin M Seré; George M Willems; Jan Rosing; Tilman M Hackeng
Protein S multimers are generated in vitro and affect protein S structure-function analyses.
Seminars in hematology 2006;43(1 Suppl 1):S111-20.
2005: Cécile V Denis; Sarah J Roberts; Tilman M Hackeng; Peter J Lenting
In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2209-15.
2005: Ingrid van Baal; Hinke Malda; Silvia A Synowsky; Joost L J van Dongen; Tilman M Hackeng; Maarten Merkx; EW Meijer
Multivalent peptide and protein dendrimers using native chemical ligation.
Angewandte Chemie (International ed. in English) 2005;44(32):5052-7.
2005: Jeffrey F W Keuren; Simone J H Wielders; Hans Ulrichts; Tilman M Hackeng; Johan W M Heemskerk; Hans Deckmyn; Edouard M Bevers; Theo Lindhout
Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):1499-505.
2005: Anouk Dirksen; Sander Langereis; Bas F M de Waal; Marcel H P van Genderen; Tilman M Hackeng; EW Meijer
A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis.
Chemical communications (Cambridge, England) 2005;(22):2811-3.
2005: Rory R Koenen; M Christella; L G D Thomassen; Guido Tans; Jan Rosing; Tilman M Hackeng
Effect of oral contraceptives on the anticoagulant activity of protein S in plasma.
Thrombosis and haemostasis 2005;93(5):853-9.
2005: Susana Ravassa; Abdelkader Bennaghmouch; Heidi Kenis; Theo Lindhout; Tilman M Hackeng; Jagat Narula; Leo Hofstra; Chris P M Reutelingsperger
Annexin A5 down-regulates surface expression of tissue factor: a novel mechanism of regulating the membrane receptor repertoir.
The Journal of biological chemistry 2005;280(7):6028-35.
2005: Philipp von Hundelshausen; Rory R Koenen; Markus Sack; Sebastian F Mause; Wencke Adriaens; Amanda E I Proudfoot; Tilman M Hackeng; Christian Weber
Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium.
Blood 2005;105(3):924-30.
2004: Anouk Dirksen; Sander Langereis; Bas F M de Waal; Marcel H P van Genderen; EW Meijer; Quido G de Lussanet; Tilman M Hackeng
Design and synthesis of a bimodal target-specific contrast agent for angiogenesis.
Organic letters 2004;6(26):4857-60.
2004: Kristin M Seré; Jan Rosing; Tilman M Hackeng
Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance.
Blood 2004;104(12):3624-30.
2004: Mary J Heeb; Rory R Koenen; José A Fernández; Tilman M Hackeng
Direct anticoagulant activity of protein S-C4b binding protein complex in Heerlen heterozygotes and normals.
Journal of thrombosis and haemostasis : JTH 2004;2(10):1766-73.
2004: Rory R Koenen; Lucio Gomes; Guido Tans; Jan Rosing; Tilman M Hackeng
The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities.
Thrombosis and haemostasis 2004;91(6):1105-14.
2004: Berry A M Soute; Da-Yun Jin; Henri M H Spronk; Vasantha P Mutucumarana; P-J Lin; Tilman M Hackeng; Darrel W Stafford; Cees Vermeer
Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase.
Journal of thrombosis and haemostasis : JTH 2004;2(4):597-604.
2003: Rory R Koenen; Guido Tans; René Van Oerle; Karly Hamulyák; Jan Rosing; Tilman M Hackeng
The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation.
Blood 2003;102(5):1686-92.
2003: Kristin M Seré; Tilman M Hackeng
Basic mechanisms of hemostasis.
Seminars in vascular medicine 2003;3(1):3-12.
2001: Kristin M Seré; Marie P Janssen; George M Willems; Guido Tans; Jan Rosing; Tilman M Hackeng
Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity.
Biochemistry 2001;40(30):8852-60.
2001: Tilman M Hackeng; Jan Rosing; Henri M H Spronk; Cees Vermeer
Total chemical synthesis of human matrix Gla protein.
Protein science : a publication of the Protein Society 2001;10(4):864-70.
2000: Tilman M Hackeng; José A Fernández; Philip E Dawson; SB Kent; John H Griffin
Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14074-8.
2000: Tilman M Hackeng; Subramanian Yegneswaran; A E Johnson; John H Griffin
Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S.
The Biochemical journal 2000;349 Pt 3():757-64.
2000: Pauline F Marx; Tilman M Hackeng; Philip E Dawson; J H Griffin; Joost C M Meijers; Bonno N Bouma
Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage.
The Journal of biological chemistry 2000;275(17):12410-5.
2000: José A Fernández; K Kojima; Jari Petäjä; Tilman M Hackeng; John H Griffin
Cardiolipin enhances protein C pathway anticoagulant activity.
Blood cells, molecules & diseases 2000;26(2):115-23.
2000: Hiroshi Deguchi; J A Fernandez; Tilman M Hackeng; Carole L Banka; John H Griffin
Cardiolipin is a normal component of human plasma lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1743-8.
1999: Tilman M Hackeng; John H Griffin; Philip E Dawson
Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10068-73.
1998: Carine M Mounier; Tilman M Hackeng; Francis Schaeffer; Grazyna FAURE; Cassian Bon; John H Griffin
Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa.
The Journal of biological chemistry 1998;273(37):23764-72.
1998: Tilman M Hackeng; Philip E Dawson; SB Kent; John H Griffin
Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module.
Biopolymers 1998;46(2):53-63.
1998: Yumi Kojima; Mary J Heeb; Andrew J Gale; Tilman M Hackeng; John H Griffin
Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va.
The Journal of biological chemistry 1998;273(24):14900-5.
1997: Tilman M Hackeng; Carine M Mounier; C Bon; Philip E Dawson; John H Griffin; SB Kent
Total chemical synthesis of enzymatically active human type II secretory phospholipase A2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7845-50.
1997: José A Fernández; Tilman M Hackeng; K Kojima; John H Griffin
The carbohydrate moiety of factor V modulates inactivation by activated protein C.
Blood 1997;89(12):4348-54.
1996: Mary J Heeb; Yumi Kojima; Tilman M Hackeng; John H Griffin
Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.
Protein science : a publication of the Protein Society 1996;5(9):1883-9.
1995: John H Griffin; Mary J Heeb; Yumi Kojima; José A Fernández; K Kojima; Tilman M Hackeng; J S Greengard
Activated protein C resistance: molecular mechanisms.
Thrombosis and haemostasis 1995;74(1):444-8.
1994: José A Fernández; Bruno Villoutreix; Tilman M Hackeng; John H Griffin; Bonno N Bouma
Analysis of protein S C4b-binding protein interactions by homology modeling and inhibitory antibodies.
Biochemistry 1994;33(37):11073-8.