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Fiona Hackett

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Christine R Collins; Fiona Hackett; Maria Penzo; M Strath; Chrislaine Withers-Martinez; David A Baker; Michael J Blackman
Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress.
Christine R Collins; Sujaan Das; Fiona Hackett; Jean-Paul Herman; Markus Meissner; Sylke Müller; Robert Stallmach; Eleanor H Wong; Nicole Andenmatten; Michael J Blackman
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Andrea Ruecker; Michael Shea; Catherine Suarez; Chrislaine Withers-Martinez; Fiona Hackett; Elizabeth M A Hirst; Katarina Milutinovic; Michael J Blackman
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.

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All Publications

2013: Christine R Collins; Fiona Hackett; Maria Penzo; M Strath; Chrislaine Withers-Martinez; David A Baker; Michael J Blackman
Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress.
PLoS pathogens 2013;9(5):e1003344.
2013: Christine R Collins; Sujaan Das; Fiona Hackett; Jean-Paul Herman; Markus Meissner; Sylke Müller; Robert Stallmach; Eleanor H Wong; Nicole Andenmatten; Michael J Blackman
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Molecular microbiology 2013;88(4):687-701.
2012: Andrea Ruecker; Michael Shea; Catherine Suarez; Chrislaine Withers-Martinez; Fiona Hackett; Elizabeth M A Hirst; Katarina Milutinovic; Michael J Blackman
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
The Journal of biological chemistry 2012;287(45):37949-63.
2012: Chrislaine Withers-Martinez; Jean-Paul Ebejer; Paul Finn; Simone Fulle; Fiona Hackett; Aigars Jirgensons; Samir Kher; Kostas Koussis; Maria Penzo; Catherine Suarez; Michael J Blackman
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
International journal for parasitology 2012;42(6):597-612.
2011: Natalie C Silmon de Monerri; Helen R Flynn; Marta G Campos; Fiona Hackett; Konstantinos Koussis; Chrislaine Withers-Martinez; J Mark Skehel; Michael J Blackman
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.
Infection and immunity 2011;79(3):1086-97.
2009: Konstantinos Koussis; Chrislaine Withers-Martinez; Sharon Yeoh; Matthew Child; Fiona Hackett; Ellen Knuepfer; Luiz Juliano; Ute Woehlbier; Hermann Bujard; Michael J Blackman
A multifunctional serine protease primes the malaria parasite for red blood cell invasion.
The EMBO journal 2009;28(6):725-35.
2009: Christine R Collins; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman
An inhibitory antibody blocks interactions between components of the malarial invasion machinery.
PLoS pathogens 2009;5(1):e1000273.
2008: Chrislaine Withers-Martinez; Lesley F Haire; Fiona Hackett; Philip A Walker; Steven A Howell; Stephen John Smerdon; Guy G Dodson; Michael J Blackman
Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.
Journal of molecular biology 2008;375(3):773-81.
2007: Sharon Yeoh; Rebecca A O'Donnell; Konstantinos Koussis; Anton R Dluzewski; Keith H Ansell; Simon A Osborne; Fiona Hackett; Chrislaine Withers-Martinez; Graham H Mitchell; Lawrence H Bannister; Justin S Bryans; Catherine A Kettleborough; Michael J Blackman
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Cell 2007;131(6):1072-83.
2006: Rebecca A O'Donnell; Fiona Hackett; Steven A Howell; Moritz Treeck; Nicole Struck; Zita Krnajski; Chrislaine Withers-Martinez; Tim-Wolf Gilberger; Michael J Blackman
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.
The Journal of cell biology 2006;174(7):1023-33.
2005: Létitia Jean; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman
Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity.
Molecular and biochemical parasitology 2005;144(2):187-97.
2005: Philippa K Harris; Sharon Yeoh; Anton R Dluzewski; Rebecca A O'Donnell; Chrislaine Withers-Martinez; Fiona Hackett; Lawrence H Bannister; Graham H Mitchell; Michael J Blackman
Molecular identification of a malaria merozoite surface sheddase.
PLoS pathogens 2005;1(3):241-51.
2005: Steven A Howell; Fiona Hackett; Artemio M Jongco; Chrislaine Withers-Martinez; Kami Kim; Vernon Bruce Carruthers; Michael J Blackman
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.
Molecular microbiology 2005;57(5):1342-56.
2005: Juan Carlos Pizarro; Brigitte Vulliez-Le Normand; Marie-Laure Chesne-seck; Christine R Collins; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman; Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Alan Thomas; Graham A Bentley
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.
Science (New York, N.Y.) 2005;308(5720):408-11.
2004: Karolina Ersmark; Isabella Feierberg; Sinisa Bjelic; Elizabeth Hamelink; Fiona Hackett; Michael J Blackman; Johan Hultén; Bertil Samuelsson; Johan Aqvist; Anders Hallberg
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.
Journal of medicinal chemistry 2004;47(1):110-22.
2003: Létitia Jean; Fiona Hackett; Stephen Martin; Michael J Blackman
Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1.
The Journal of biological chemistry 2003;278(31):28572-9.
2002: Chrislaine Withers-Martinez; José W Saldanha; Barry Ely; Fiona Hackett; Tony O'Connor; Michael J Blackman
Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.
The Journal of biological chemistry 2002;277(33):29698-709.
2002: Clemens H M Kocken; Chrislaine Withers-Martinez; Martin A Dubbeld; Annemarie van der Wel; Fiona Hackett; Augusto Valderrama; Michael J Blackman; Alan Thomas
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.
Infection and immunity 2002;70(8):4471-6.
1999: Chrislaine Withers-Martinez; E P Carpenter; Fiona Hackett; B Ely; M Sajid; Munira Grainger; Michael J Blackman
PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.
Protein engineering 1999;12(12):1113-20.
1999: Fiona Hackett; M Sajid; Chrislaine Withers-Martinez; Munira Grainger; Michael J Blackman
PfSUB-2: a second subtilisin-like protein in Plasmodium falciparum merozoites.
Molecular and biochemical parasitology 1999;103(2):183-95.
1998: Michael J Blackman; H Fujioka; W H Stafford; M Sajid; Barbara Clough; Suzanne L Fleck; M Aikawa; Munira Grainger; Fiona Hackett
A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites.
The Journal of biological chemistry 1998;273(36):23398-409.
1993: Louis Schofield; L Vivas; Fiona Hackett; Peter Gerold; Ralph T Schwarz; SD Tachado
Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.
Annals of tropical medicine and parasitology 1993;87(6):617-26.
1993: Louis Schofield; Fiona Hackett
Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.
The Journal of experimental medicine 1993;177(1):145-53.
1993: Fiona Hackett
The culture of Schistosoma mansoni and production of life cycle stages.
Methods in molecular biology (Clifton, N.J.) 1993;21():89-99.
1991: P O Ali; S A Jeffs; H M Meadows; T Hollyer; C A Owen; F G Abath; R Allen; Fiona Hackett; S R Smithers; Andrew J G Simpson
Structure of Sm25, an antigenic integral membrane glycoprotein of adult Schistosoma mansoni.
Molecular and biochemical parasitology 1991;45(2):215-22.
1990: Andrew J G Simpson; P Hagan; Fiona Hackett; P Omer Ali; S R Smithers
Epitopes expressed on very low Mr Schistosoma mansoni adult tegumental antigens conform to a general pattern of life-cycle cross-reactivity.
Parasitology 1990;100 Pt 1():73-81.
1990: S R Smithers; Fiona Hackett; V Braga; Andrew J G Simpson
Immunoblotting identifies additional antigens recognised by mice protectively vaccinated with adult Schistosoma mansoni tegumental membranes.
Parasitology research 1990;76(5):454-6.
1989: S R Smithers; Fiona Hackett; P O Ali; Andrew J G Simpson
Protective immunization of mice against Schistosoma mansoni with purified adult worm surface membranes.
Parasite immunology 1989;11(4):301-18.
1989: P Omer Ali; P Hagan; Fiona Hackett; S R Smithers; Andrew J G Simpson
Variable species and stage specificity of schistosomulum surface epitopes recognized by mice vaccinated with highly irradiated cercariae.
Parasite immunology 1989;11(3):257-67.
1987: C Kelly; P Hagan; M Knight; J Hodgson; Andrew J G Simpson; Fiona Hackett; H A Wilkins; S R Smithers
Surface and species-specific antigens of Schistosoma haematobium.
Parasitology 1987;95 ( Pt 2)():253-66.
1987: Andrew J G Simpson; M Knight; C Kelly; Fiona Hackett; P Omer-Ali; S R Smithers
The cloning of schistosome antigens.
Acta tropica. Supplementum 1987;12():83-9.
1987: Fiona Hackett; Andrew J G Simpson; P Omer-Ali; S R Smithers
Surface antigens of and cross-protection between two geographical isolates of Schistosoma mansoni.
Parasitology 1987;94 ( Pt 2)():301-12.
1986: Andrew J G Simpson; Fiona Hackett; C Kelly; M Knight; gilberto payares; P Omer-Ali; J Lillywhite; S L Fleck; S R Smithers
The recognition of Schistosoma mansoni surface antigens by antibodies from patients infected with S. mansoni and S. haematobium.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1986;80(2):261-70.
1985: Fiona Hackett; Andrew J G Simpson; M Knight; P Ali; gilberto payares; S R Smithers
Schistosoma mansoni: antigen preparations which induce antibodies to schistosomula surface antigens.
Experimental parasitology 1985;60(3):294-303.
1985: Andrew J G Simpson; Fiona Hackett; T Walker; R de Rossi; S R Smithers
Antibody response against schistosomulum surface antigens and protective immunity following immunization with highly irradiated cercariae of Schistosoma mansoni.
Parasite immunology 1985;7(2):133-52.