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Guy Haegeman

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TOP 3
Wim Vanden Berghe; Guy Haegeman; Mary Kaileh; Linde Sabbe; Karen Heyninck
Molecular insight in the multifunctional activities of Withaferin A.
Evelien Gellynck; Guy Haegeman; Finn Olav Levy; Béatrice Lintermans; Kjetil Wessel Andressen; Peter Vanhoenacker; Kathleen Van Craenenbroeck
Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor.
Anne Matthys; Kathleen Van Craenenbroeck; Guy Haegeman; Béatrice Lintermans; Peter Vanhoenacker
RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.

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All Publications

2012: Wim Vanden Berghe; Guy Haegeman; Mary Kaileh; Linde Sabbe; Karen Heyninck
Molecular insight in the multifunctional activities of Withaferin A.
Biochemical pharmacology 2012;84(10):1282-91.
2012: Evelien Gellynck; Guy Haegeman; Finn Olav Levy; Béatrice Lintermans; Kjetil Wessel Andressen; Peter Vanhoenacker; Kathleen Van Craenenbroeck
Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor.
The FEBS journal 2012;279(11):1994-2003.
2012: Anne Matthys; Kathleen Van Craenenbroeck; Guy Haegeman; Béatrice Lintermans; Peter Vanhoenacker
RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.
Cellular signalling 2012;24(5):1053-63.
2011: Sarah Gerlo; Krzysztof Kolmus; Ron Kooijman; Anneleen Spooren; Ilse M Beck; Guy Haegeman
Cyclic AMP: a selective modulator of NF-κB action.
Cellular and molecular life sciences : CMLS 2011;68(23):3823-41.
2011: Wim Vanden Berghe; Jean-Pierre David; Denis De Keukeleire; An De Naeyer; Nathalie Dijsselbloem; Guy Haegeman
Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.
Endocrine, metabolic & immune disorders drug targets 2011;11(3):247-61.
2011: Anneleen Spooren; Krzysztof Kolmus; Guy Laureys; Ralph Clinckers; Jacques De Keyser; Guy Haegeman; Sarah Gerlo
Interleukin-6, a mental cytokine.
Brain research reviews 2011;67(1-2):157-83.
2011: Anne Matthys; Guy Haegeman; Kathleen Van Craenenbroeck; Peter Vanhoenacker
Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.
Molecular neurobiology 2011;43(3):228-53.
2011: Anneleen Spooren; Pieter Mestdagh; Pieter Rondou; Krzysztof Kolmus; Guy Haegeman; Sarah Gerlo
IL-1β potently stabilizes IL-6 mRNA in human astrocytes.
Biochemical pharmacology 2011;81(8):1004-15.
2011: Kathleen Van Craenenbroeck; Dasiel Borroto-Escuela; Wilber Romero-Fernandez; Kamila Skieterska; Pieter Rondou; Béatrice Lintermans; Peter Vanhoenacker; Kjell Fuxe; Francisco Ciruela; Guy Haegeman
Dopamine D4 receptor oligomerization--contribution to receptor biogenesis.
The FEBS journal 2011;278(8):1333-44.
2011: Alexander Rauch; Valerie Gossye; Debby Bracke; Elien Gevaert; Peggy Jacques; Katrien van Beneden; Bernard Vandooren; Martina Rauner; Lorenz C Hofbauer; Guy Haegeman; Dirk Elewaut; Jan P Tuckermann; Karolien De Bosscher
An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1323-32.
2010: Katarzyna Szarc vel Szic; Matladi N Ndlovu; Guy Haegeman; Wim Vanden Berghe
Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders.
Biochemical pharmacology 2010;80(12):1816-32.
2010: Karolien De Bosscher; Ilse M Beck; Guy Haegeman
Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?
Brain, behavior, and immunity 2010;24(7):1035-42.
2010: Karolien De Bosscher; Guy Haegeman; Dirk Elewaut
Targeting inflammation using selective glucocorticoid receptor modulators.
Current opinion in pharmacology 2010;10(4):497-504.
2010: Wim Vanden Berghe; Guy Haegeman
Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?
Current drug metabolism 2010;11(5):436-50.
2010: Pieter Rondou; Guy Haegeman; Kathleen Van Craenenbroeck
The dopamine D4 receptor: biochemical and signalling properties.
Cellular and molecular life sciences : CMLS 2010;67(12):1971-86.
2010: Pieter Rondou; Kamila Skieterska; Ann Packeu; Béatrice Lintermans; Peter Vanhoenacker; Georges Vauquelin; Guy Haegeman; Kathleen Van Craenenbroeck
KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation.
Cellular signalling 2010;22(6):900-13.
2010: Anneleen Spooren; Ron Kooijman; Béatrice Lintermans; Kathleen Van Craenenbroeck; Linda Vermeulen; Guy Haegeman; Sarah Gerlo
Cooperation of NFkappaB and CREB to induce synergistic IL-6 expression in astrocytes.
Cellular signalling 2010;22(5):871-81.
2010: Anneleen Spooren; Pieter Rondou; Katarzyna Debowska; Béatrice Lintermans; Linda Vermeulen; Bart Samyn; Kamila Skieterska; GRIET DEBYSER; Bart Devreese; Peter Vanhoenacker; Urszula Wojda; Guy Haegeman; Kathleen Van Craenenbroeck
Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation.
Cellular signalling 2010;22(4):600-9.
2010: Steven Robertson; Fatima Allie-Reid; Wim Vanden Berghe; Koch Visser; Anke Binder; Donita Africander; Michael Vismer; Karolien De Bosscher; Janet Hapgood; Guy Haegeman; Ann Louw
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a.
The Journal of biological chemistry 2010;285(11):8061-75.
2010: Geert Van Loo; Mozes Sze; Nadia Bougarne; Jelle Praet; Conor Mc Guire; Andrea Ullrich; Guy Haegeman; Marco Prinz; Rudi Beyaert; Karolien De Bosscher
Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis.
Molecular endocrinology (Baltimore, Md.) 2010;24(2):310-22.
2010: Wipob Suttana; Samlee Mankhetkorn; Wilart Poompimon; Ajay Palagani; Sergey Zhokhov; Sarah Gerlo; Guy Haegeman; Wim Vanden Berghe
Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.
Molecular cancer 2010;9():99.
2010: Anneleen Spooren; Krzysztof Kolmus; Linda Vermeulen; Karlien Van Wesemael; Guy Haegeman; Sarah Gerlo
Hunting for serine 276-phosphorylated p65.
Journal of biomedicine & biotechnology 2010;2010():275892.
2010: V Gossye; Dirk Elewaut; Katrien van Beneden; pieter dewint; Guy Haegeman; Karolien De Bosscher
A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance.
Annals of the rheumatic diseases 2010;69(1):291-6.
2009: Ilse M E Beck; Wim Vanden Berghe; Linda Vermeulen; Keith R Yamamoto; Guy Haegeman; Karolien De Bosscher
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases.
Endocrine reviews 2009;30(7):830-82.
2009: Valerie Gossye; Dirk Elewaut; Nadia Bougarne; Debby Bracke; Serge Van Calenbergh; Guy Haegeman; Karolien De Bosscher
Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2009;60(11):3241-50.
2009: Sofie Lust; Barbara Vanhoecke; Mireille Van Gele; Jerina Boelens; Heleen VAN Melckebeke; Mary Kaileh; Wim Vanden Berghe; Guy Haegeman; Jan Philippé; Marc Bracke; Fritz Offner
Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia.
Anticancer research 2009;29(10):3797-805.
2009: 'Matladi N Ndlovu; Carine Van Lint; Karlien Van Wesemael; Pieter Callebert; Dany Chalbos; Guy Haegeman; Wim Vanden Berghe
Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells.
Molecular and cellular biology 2009;29(20):5488-504.
2009: Marjan Van Cleemput; Arne Heyerick; Claude Libert; Katrien Swerts; Jan Philippé; Denis De Keukeleire; Guy Haegeman; Karolien De Bosscher
Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma.
Molecular nutrition & food research 2009;53(9):1143-55.
2009: Nadia Bougarne; Réjane Paumelle; Guy Haegeman; Bart Staels; Karolien De Bosscher
Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.
Cell cycle (Georgetown, Tex.) 2009;8(15):2311-2.
2009: Marjan Van Cleemput; Ko Cattoor; Karolien De Bosscher; Guy Haegeman; Denis De Keukeleire; Arne Heyerick
Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.
Journal of natural products 2009;72(6):1220-30.
2009: Linda Vermeulen; Wim Vanden Berghe; Ilse M E Beck; Karolien De Bosscher; Guy Haegeman
The versatile role of MSKs in transcriptional regulation.
Trends in biochemical sciences 2009;34(6):311-8.
2009: Nadia Bougarne; Réjane Paumelle; Sandrine Caron; Nathalie Hennuyer; Roxane Mansouri; Philippe Gervois; Bart Staels; Guy Haegeman; Karolien De Bosscher
PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7397-402.
2009: Karolien De Bosscher; Guy Haegeman
Minireview: latest perspectives on antiinflammatory actions of glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):281-91.
2008: Evelien Gellynck; Koen Laenen; Kjetil Wessel Andressen; Béatrice Lintermans; Kim De Martelaere; Anne Matthys; Finn Olav Levy; Guy Haegeman; Peter Vanhoenacker; Kathleen Van Craenenbroeck
Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain.
Gene 2008;426(1-2):23-31.
2008: Sarah Gerlo; Guy Haegeman; Wim Vanden Berghe
Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells.
Cellular signalling 2008;20(8):1489-96.
2008: Ilse M E Beck; Wim Vanden Berghe; Linda Vermeulen; Nadia Bougarne; Bert Vander Cruyssen; Guy Haegeman; Karolien De Bosscher
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition.
The EMBO journal 2008;27(12):1682-93.
2008: Pieter Rondou; Guy Haegeman; Peter Vanhoenacker; Kathleen Van Craenenbroeck
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase.
The Journal of biological chemistry 2008;283(17):11083-96.
2008: Karolien De Bosscher; Kathleen Van Craenenbroeck; Onno C Meijer; Guy Haegeman
Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems.
European journal of pharmacology 2008;583(2-3):290-302.
2008: pieter dewint; Valerie Gossye; Karolien De Bosscher; Wim Vanden Berghe; Katrien van Beneden; Dieter Deforce; Serge Van Calenbergh; Ulf Müller-Ladner; Bert Vander Cruyssen; Gust Verbruggen; Guy Haegeman; Dirk Elewaut
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2608-15.
2008: Valerie Gossye; Guy Haegeman; Karolien De Bosscher
Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk.
Frontiers in bioscience : a journal and virtual library 2008;13():4122-43.
2007: Mary Kaileh; Wim Vanden Berghe; Elke Boone; Tamer Essawi; Guy Haegeman
Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity.
Journal of ethnopharmacology 2007;113(3):510-6.
2007: Mathias Laga; Anneleen Cottyn; Franky Van Herreweghe; Wim Vanden Berghe; Guy Haegeman; Patrick Van Oostveldt; Joël Vandekerckhove; Katia Vancompernolle
Methylglyoxal suppresses TNF-alpha-induced NF-kappaB activation by inhibiting NF-kappaB DNA-binding.
Biochemical pharmacology 2007;74(4):579-89.
2007: Frauke Coppieters; Bart P Leroy; Diane Beysen; Jan Hellemans; Karolien De Bosscher; Guy Haegeman; Kirsten Robberecht; Wim Wuyts; Paul J Coucke; Elfride De Baere
Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa.
American journal of human genetics 2007;81(1):147-57.
2007: Julie Horion; Geoffrey Gloire; Nadia El Mjiyad; Vincent Quivy; Linda Vermeulen; Wim Vanden Berghe; Guy Haegeman; Carine Van Lint; Jacques Piette; Yvette Habraken
Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.
The Journal of biological chemistry 2007;282(21):15383-93.
2007: Nathalie Dijsselbloem; Stanislas Goriely; Valentina Albarani; Sarah Gerlo; Sarah Francoz; Jean-Christophe Marine; Michel Goldman; Guy Haegeman; Wim Vanden Berghe
A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5048-57.
2007: Koen Laenen; Guy Haegeman; Peter Vanhoenacker
Structure of the human 5-HT7 receptor gene and characterization of its promoter region.
Gene 2007;391(1-2):252-63.
2007: Mary Kaileh; Wim Vanden Berghe; Arne Heyerick; Julie Horion; Jacques Piette; Claude Libert; Denis De Keukeleire; Tamer Essawi; Guy Haegeman
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.
The Journal of biological chemistry 2007;282(7):4253-64.
2007: Kim De Martelaere; Béatrice Lintermans; Guy Haegeman; Peter Vanhoenacker
Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k.
Cellular signalling 2007;19(2):278-88.
2006: Kathleen Van Craenenbroeck; Evelien Gellynck; Béatrice Lintermans; Josée E Leysen; Hubert H M Van Tol; Guy Haegeman; Peter Vanhoenacker
Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor.
Life sciences 2006;80(1):74-81.
2006: Karolien De Bosscher; Wim Vanden Berghe; Guy Haegeman
Cross-talk between nuclear receptors and nuclear factor kappaB.
Oncogene 2006;25(51):6868-86.
2006: Wim Vanden Berghe; Matladi N Ndlovu; Ruben Hoya-Arias; Nathalie Dijsselbloem; Sarah Gerlo; Guy Haegeman
Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
Biochemical pharmacology 2006;72(9):1114-31.
2006: Wim Vanden Berghe; Nathalie Dijsselbloem; Linda Vermeulen; 'Matladi N Ndlovu; Elke Boone; Guy Haegeman
Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity.
Cancer research 2006;66(9):4852-62.
2006: Linda Vermeulen; Wim Vanden Berghe; Guy Haegeman
Regulation of NF-kappaB transcriptional activity.
Cancer treatment and research 2006;130():89-102.
2005: Kathleen Van Craenenbroeck; Karolien De Bosscher; Wim Vanden Berghe; Peter Vanhoenacker; Guy Haegeman
Role of glucocorticoids in dopamine-related neuropsychiatric disorders.
Molecular and cellular endocrinology 2005;245(1-2):10-22.
2005: Karolien De Bosscher; Wim Vanden Berghe; Ilse M E Beck; Wim Van Molle; Nathalie Hennuyer; Janet Patricia Hapgood; Claude Libert; Bart Staels; Ann Louw; Guy Haegeman
A fully dissociated compound of plant origin for inflammatory gene repression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15827-32.
2005: Ezra Aksoy; Wim Vanden Berghe; Sophie Detienne; Zoulikha Amraoui; Kathrine A Fitzgerald; Guy Haegeman; Michel Goldman; Fabienne Willems
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.
European journal of immunology 2005;35(7):2200-9.
2005: Vladimir T Todorov; Simon Völkl; Juergen Friedrich; Leoni A Kunz-Schughart; Thomas Hehlgans; Linda Vermeulen; Guy Haegeman; M Lienhard Schmitz; Armin Kurtz
Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}.
The Journal of biological chemistry 2005;280(26):24356-62.
2005: Simone de Haij; Astrid C Bakker; Reinier N van der Geest; Guy Haegeman; Wim Vanden Berghe; Jamil Aarbiou; Mohamed R Daha; Cees van Kooten
NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase.
Journal of the American Society of Nephrology : JASN 2005;16(6):1603-11.
2004: Cristina Aguilera; Ruben Hoya-Arias; Guy Haegeman; Lluís Espinosa; Anna Bigas
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16537-42.
2004: An De Naeyer; Wim Vanden Berghe; Victoria Pocock; Stuart Milligan; Guy Haegeman; Denis De Keukeleire
Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens.
Journal of natural products 2004;67(11):1829-32.
2004: Nathalie Dijsselbloem; Wim Vanden Berghe; An De Naeyer; Guy Haegeman
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy.
Biochemical pharmacology 2004;68(6):1171-85.
2004: Dominique Koubovec; Wim Vanden Berghe; Linda Vermeulen; Guy Haegeman; Janet Patricia Hapgood
Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells.
Molecular and cellular endocrinology 2004;221(1-2):75-85.
2004: Adelheid De Ketelaere; Linda Vermeulen; Jorge Vialard; Inez Van de Weyer; Jean Van Wauwe; Guy Haegeman; Inge Moelans
Involvement of GSK-3beta in TWEAK-mediated NF-kappaB activation.
FEBS letters 2004;566(1-3):60-4.
2004: Greet Brouckaert; Michael Kalai; Dmitri V Krysko; Xavier Saelens; Dominique Vercammen; 'Matladi Ndlovu; Guy Haegeman; Katharina D'Herde; Matladi N Ndlovu; Peter Vandenabeele
Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production.
Molecular biology of the cell 2004;15(3):1089-100.
2003: Kathleen Van Craenenbroeck; Peter Vanhoenacker; Inge Roman; Guy Haegeman
Orientation-dependent gene expression with Epstein-Barr virus-derived vectors.
FEBS letters 2003;555(3):489-94.
2003: Karolien De Bosscher; Wim Vanden Berghe; Guy Haegeman
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.
Endocrine reviews 2003;24(4):488-522.
2003: Linda Vermeulen; Gert De Wilde; Petra Van Damme; Wim Vanden Berghe; Guy Haegeman
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
The EMBO journal 2003;22(6):1313-24.
2003: Sabrina Devos; Karolien De Bosscher; Bart Staels; Ellinor Bauer; Frank Roels; Wim Vanden Berghe; Guy Haegeman; Robert Hooghe; Elisabeth L Hooghe-Peters
Inhibition of cytokine production by the herbicide atrazine. Search for nuclear receptor targets.
Biochemical pharmacology 2003;65(2):303-8.
2003: Wim Vanden Berghe; Linda Vermeulen; Philippe Delerive; Karolien De Bosscher; Bart Staels; Guy Haegeman
A paradigm for gene regulation: inflammation, NF-kappaB and PPAR.
Advances in experimental medicine and biology 2003;544():181-96.
2002: Linda Vermeulen; Gert De Wilde; Sofie Notebaert; Wim Vanden Berghe; Guy Haegeman
Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.
Biochemical pharmacology 2002;64(5-6):963-70.
2002: Philippe Delerive; Karolien De Bosscher; Wim Vanden Berghe; Jean-Charles Fruchart; Guy Haegeman; Bart Staels
DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1029-39.
2002: Wim Vanden Berghe; Karolien De Bosscher; Linda Vermeulen; Gert De Wilde; Guy Haegeman
Induction and repression of NF-kappa B-driven inflammatory genes.
Ernst Schering Research Foundation workshop 2002;(40):233-78.
2001: Gert De Wilde; Nico Mertens; Elke Boone; B De Vreese; J Van Beeumen; Walter Fiers; Guy Haegeman
Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.
Protein expression and purification 2001;23(2):226-32.
2001: Kathleen Van Craenenbroeck; Peter Vanhoenacker; Josée E Leysen; Guy Haegeman
Evaluation of the tetracycline- and ecdysone-inducible systems for expression of neurotransmitter receptors in mammalian cells.
The European journal of neuroscience 2001;14(6):968-76.
2001: Gert De Wilde; Judith Murray-Rust; Elke Boone; D Olerenshaw; Neil McDonald; C Ibanez; Guy Haegeman; Axel Wollmer; M Federwisch
Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.
European journal of biochemistry / FEBS 2001;268(5):1382-91.
2001: Karolien De Bosscher; Wim Vanden Berghe; Guy Haegeman
Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators.
Molecular endocrinology (Baltimore, Md.) 2001;15(2):219-27.
2000: Elke Boone; Tom Vanden Berghe; Geert Van Loo; Gert De Wilde; N De Wael; Dominique Vercammen; Walter Fiers; Guy Haegeman; Peter Vandenabeele
Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.
The Journal of biological chemistry 2000;275(48):37596-603.
2000: Wim Vanden Berghe; Linda Vermeulen; Gert De Wilde; Karolien De Bosscher; Elke Boone; Guy Haegeman
Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.
Biochemical pharmacology 2000;60(8):1185-95.
2000: Kathleen Van Craenenbroeck; Peter Vanhoenacker; Guy Haegeman
Episomal vectors for gene expression in mammalian cells.
European journal of biochemistry / FEBS 2000;267(18):5665-78.
2000: Karolien De Bosscher; Wim Vanden Berghe; Guy Haegeman
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors.
Journal of neuroimmunology 2000;109(1):16-22.
2000: Kathleen Van Craenenbroeck; Peter Vanhoenacker; H Duchau; Guy Haegeman
Molecular integrity and usefulness of episomal expression vectors derived from BK and Epstein-Barr virus.
Gene 2000;253(2):293-301.
2000: Karolien De Bosscher; Wim Vanden Berghe; Linda Vermeulen; Stephane Plaisance; Elke Boone; Guy Haegeman
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3919-24.
2000: Peter Vanhoenacker; Guy Haegeman; Josée E Leysen
5-HT7 receptors: current knowledge and future prospects.
Trends in pharmacological sciences 2000;21(2):70-7.
1999: Wim Vanden Berghe; Karolien De Bosscher; Elke Boone; Stephane Plaisance; Guy Haegeman
The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.
The Journal of biological chemistry 1999;274(45):32091-8.
1999: Philippe Delerive; Karolien De Bosscher; S Besnard; Wim Vanden Berghe; J M Peters; F J Gonzalez; Jean-Charles Fruchart; Alain Tedgui; Guy Haegeman; Bart Staels
Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1.
The Journal of biological chemistry 1999;274(45):32048-54.
1999: Wim Vanden Berghe; E Francesconi; Karolien De Bosscher; M Resche-Rigon; Guy Haegeman
Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism.
Molecular pharmacology 1999;56(4):797-806.
1999: Karen Heyninck; D De Valck; Wim Vanden Berghe; Wim van Criekinge; R Contreras; Walter Fiers; Guy Haegeman; Rudi Beyaert
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
The Journal of cell biology 1999;145(7):1471-82.
1999: Valérie Verhasselt; Wim Vanden Berghe; Nathalie Vanderheyde; Fabienne Willems; Guy Haegeman; Michel Goldman
N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2569-74.
1999: Maikel Peppelenbosch; Elke Boone; G E Jones; S J van Deventer; Guy Haegeman; Walter Fiers; Johan Grooten; Anne J Ridley
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):837-45.
1998: Elke Boone; V Vandevoorde; Gert De Wilde; Guy Haegeman
Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor.
FEBS letters 1998;441(2):275-80.
1998: Peter Vanhoenacker; I Van den Bogerd; W Gommeren; Walter H M L Luyten; Josée E Leysen; Guy Haegeman
Efficient expression of neurotransmitter receptors in mammalian cells: use of inducible expression systems.
Annals of the New York Academy of Sciences 1998;861():236-7.
1998: K De Vos; Vera Goossens; Elke Boone; Dominique Vercammen; Katia Vancompernolle; Peter Vandenabeele; Guy Haegeman; Walter Fiers; Johan Grooten
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
The Journal of biological chemistry 1998;273(16):9673-80.
1998: Anne Lesage; Ria Wouters; Paul van Gompel; Lieve I Heylen; Peter Vanhoenacker; Guy Haegeman; Walter H M L Luyten; Josée E Leysen
Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.
British journal of pharmacology 1998;123(8):1655-65.
1998: Wim Vanden Berghe; Stephane Plaisance; Elke Boone; Karolien De Bosscher; M Lienhard Schmitz; Walter Fiers; Guy Haegeman
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.
The Journal of biological chemistry 1998;273(6):3285-90.
1998: E Decoster; B Vanhaesebroeck; Elke Boone; Stephane Plaisance; K De Vos; Guy Haegeman; Johan Grooten; Walter Fiers
Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
The Journal of biological chemistry 1998;273(6):3271-7.
1997: Karolien De Bosscher; M Lienhard Schmitz; Wim Vanden Berghe; Stephane Plaisance; Walter Fiers; Guy Haegeman
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13504-9.
1997: E Decoster; V Vandevoorde; Rudi Beyaert; Guy Haegeman; Walter Fiers
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.
FEBS letters 1997;416(2):183-6.
1997: Stephane Plaisance; Wim Vanden Berghe; Elke Boone; Walter Fiers; Guy Haegeman
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.
Molecular and cellular biology 1997;17(7):3733-43.
1997: V Vandevoorde; Guy Haegeman; Walter Fiers
Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.
The Journal of cell biology 1997;137(7):1627-38.
1997: Peter Vanhoenacker; W Gommeren; Walter H M L Luyten; Josée E Leysen; Guy Haegeman
Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system.
Receptors & channels 1997;5(3-4):125-37.
1996: Josée E Leysen; W Gommeren; L Heylen; Walter H M L Luyten; Inez Van de Weyer; Peter Vanhoenacker; Guy Haegeman; A Schotte; P Van Gompel; R Wouters; A S Lesage
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.
Molecular pharmacology 1996;50(6):1567-80.
1996: Rudi Beyaert; A Cuenda; Wim Vanden Berghe; Stephane Plaisance; J C Lee; Guy Haegeman; P Cohen; Walter Fiers
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
1995: Walter Fiers; Rudi Beyaert; Elke Boone; Sigrid Cornelis; Wim Declercq; E Decoster; Geertrui Denecker; B Depuydt; D De Valck; G De Wilde; Vera Goossens; Johan Grooten; Guy Haegeman; Karen Heyninck; Louis C Penning; Stephane Plaisance; Katia Vancompernolle; Wim van Criekinge; Peter Vandenabeele; Wim Vanden Berghe; M Van de Craen; V Vandevoorde; Dominique Vercammen
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
1994: Peter Vanhoenacker; Walter Fiers; Guy Haegeman
Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.
European cytokine network 1994;5(3):283-91.
1993: K Schulze-Osthoff; Rudi Beyaert; V Vandevoorde; Guy Haegeman; Walter Fiers
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
The EMBO journal 1993;12(8):3095-104.
1993: Rudi Beyaert; B Vanhaesebroeck; Karen Heyninck; Elke Boone; D De Valck; K Schulze-Osthoff; Guy Haegeman; Frans van Roy; Walter Fiers
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
1993: N P Patestos; Guy Haegeman; V Vandevoorde; Walter Fiers
Activation of the nuclear factor kappa B is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression.
Biochimie 1993;75(11):1007-18.
1992: Johan Van Lint; Patrizia Agostinis; V Vandevoorde; Guy Haegeman; Walter Fiers; Wilfried Merlevede; Jackie R Vandenheede
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
The Journal of biological chemistry 1992;267(36):25916-21.
1992: V Vandevoorde; Guy Haegeman; Walter Fiers
TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells.
FEBS letters 1992;302(3):235-8.
1992: N P Patestos; Guy Haegeman; Walter Fiers
TNF-induced, cytotoxicity-linked IL6 gene expression in L929 cells may require factors other than NF-kappa B.
Biochemical Society transactions 1992;20(1):80S.
1991: V Vandevoorde; Guy Haegeman; Walter Fiers
Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells.
Biochemical and biophysical research communications 1991;178(3):993-1001.
1991: Y Guisez; B Tison; Joël Vandekerckhove; J Demolder; Guy Bauw; Guy Haegeman; Walter Fiers; Roland Contreras
Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1991;198(1):217-22.
1987: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; Guy Haegeman; P Suffys; Jan Tavernier; Peter Vandenabeele; B Vanhaesebroeck; X Van Ostade
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins.
Immunology letters 1987;16(3-4):219-26.
1987: P Poupart; P Vandenabeele; S Cayphas; J Van Snick; Guy Haegeman; Véronique Kruys; W Fiers; J Content
B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF).
The EMBO journal 1987;6(5):1219-24.