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Guy Haegeman
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39
Vanden Berghe, Wim
29
De Bosscher, Karolien
23
Fiers, Walter
16
Boone, Elke
16
Vanhoenacker, Peter
13
Vermeulen, Linda
9
Van Craenenbroeck, Kathleen
8
Plaisance, Stephane
8
De Wilde, Gert
7
Beyaert, Rudi
7
Staels, Bart
7
Leysen, Josée
5
Vandenabeele, Peter
4
Vercammen, Dominique
4
De Keukeleire, Denis
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All Publications
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2009: Gossye Valerie; Elewaut Dirk; Bougarne Nadia; Bracke Debby; Van Calenbergh Serge; Haegeman Guy; De Bosscher Karolien
Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts.
Arthritis and rheumatism 2009;60(11):3241-50.
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2009: Lust Sofie; Vanhoecke Barbara; VAN Gele Mireille; Boelens Jerina; VAN Melckebeke Heleen; Kaileh Mary; Vanden Berghe Wim; Haegeman Guy; Philippé Jan; Bracke Marc; Offner Fritz
Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia.
Anticancer research 2009;29(10):3797-805.
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2009: Ndlovu 'matladi N; Van Lint Carine; Van Wesemael Karlien; Callebert Pieter; Chalbos Dany; Haegeman Guy; Vanden Berghe Wim
Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells.
Molecular and cellular biology 2009;29(20):5488-504.
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2009: Van Cleemput Marjan; Heyerick Arne; Libert Claude; Swerts Katrien; Philippé Jan; De Keukeleire Denis; Haegeman Guy; De Bosscher Karolien
Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma.
Molecular nutrition & food research 2009;53(9):1143-55.
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2009: Bougarne Nadia; Paumelle Réjane; Haegeman Guy; Staels Bart; De Bosscher Karolien
Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.
Cell cycle (Georgetown, Tex.) 2009;8(15):2311-2.
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2009: Van Cleemput Marjan; Cattoor Ko; De Bosscher Karolien; Haegeman Guy; De Keukeleire Denis; Heyerick Arne
Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds.
Journal of natural products 2009;72(6):1220-30.
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2009: Vermeulen Linda; Berghe Wim Vanden; Beck Ilse M E; De Bosscher Karolien; Haegeman Guy
The versatile role of MSKs in transcriptional regulation.
Trends in biochemical sciences 2009;34(6):311-8.
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2009: Bougarne Nadia; Paumelle Réjane; Caron Sandrine; Hennuyer Nathalie; Mansouri Roxane; Gervois Philippe; Staels Bart; Haegeman Guy; De Bosscher Karolien
PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7397-402.
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2009: De Bosscher Karolien; Haegeman Guy
Minireview: latest perspectives on antiinflammatory actions of glucocorticoids.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):281-91.
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2008: Gellynck Evelien; Laenen Koen; Andressen Kjetil Wessel; Lintermans Béatrice; De Martelaere Kim; Matthys Anne; Levy Finn Olav; Haegeman Guy; Vanhoenacker Peter; Van Craenenbroeck Kathleen
Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain.
Gene 2008;426(1-2):23-31.
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2008: Gerlo Sarah; Haegeman Guy; Vanden Berghe Wim
Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells.
Cellular signalling 2008;20(8):1489-96.
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2008: Beck Ilse M E; Vanden Berghe Wim; Vermeulen Linda; Bougarne Nadia; Vander Cruyssen Bert; Haegeman Guy; De Bosscher Karolien
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition.
The EMBO journal 2008;27(12):1682-93.
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2008: Rondou Pieter; Haegeman Guy; Vanhoenacker Peter; Van Craenenbroeck Kathleen
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase.
The Journal of biological chemistry 2008;283(17):11083-96.
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2008: De Bosscher Karolien; Van Craenenbroeck Kathleen; Meijer Onno C; Haegeman Guy
Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems.
European journal of pharmacology 2008;583(2-3):290-302.
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2008: Dewint Pieter; Gossye Valerie; De Bosscher Karolien; Vanden Berghe Wim; Van Beneden Katrien; Deforce Dieter; Van Calenbergh Serge; Müller-Ladner Ulf; Vander Cruyssen Bert; Verbruggen Gust; Haegeman Guy; Elewaut Dirk
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2608-15.
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2008: Gossye Valerie; Haegeman Guy; De Bosscher Karolien
Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk.
Frontiers in bioscience : a journal and virtual library 2008;13():4122-43.
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2007: Kaileh Mary; Berghe Wim Vanden; Boone Elke; Essawi Tamer; Haegeman Guy
Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity.
Journal of ethnopharmacology 2007;113(3):510-6.
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2007: Laga Mathias; Cottyn Anneleen; Van Herreweghe Franky; Vanden Berghe Wim; Haegeman Guy; Van Oostveldt Patrick; Vandekerckhove Joël; Vancompernolle Katia
Methylglyoxal suppresses TNF-alpha-induced NF-kappaB activation by inhibiting NF-kappaB DNA-binding.
Biochemical pharmacology 2007;74(4):579-89.
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2007: Coppieters Frauke; Leroy Bart P; Beysen Diane; Hellemans Jan; De Bosscher Karolien; Haegeman Guy; Robberecht Kirsten; Wuyts Wim; Coucke Paul J; De Baere Elfride
Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa.
American journal of human genetics 2007;81(1):147-57.
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2007: Horion Julie; Gloire Geoffrey; El Mjiyad Nadia; Quivy Vincent; Vermeulen Linda; Vanden Berghe Wim; Haegeman Guy; Van Lint Carine; Piette Jacques; Habraken Yvette
Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.
The Journal of biological chemistry 2007;282(21):15383-93.
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2007: Dijsselbloem Nathalie; Goriely Stanislas; Albarani Valentina; Gerlo Sarah; Francoz Sarah; Marine Jean-Christophe; Goldman Michel; Haegeman Guy; Vanden Berghe Wim
A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5048-57.
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2007: Laenen Koen; Haegeman Guy; Vanhoenacker Peter
Structure of the human 5-HT7 receptor gene and characterization of its promoter region.
Gene 2007;391(1-2):252-63.
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2007: Kaileh Mary; Vanden Berghe Wim; Heyerick Arne; Horion Julie; Piette Jacques; Libert Claude; De Keukeleire Denis; Essawi Tamer; Haegeman Guy
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.
The Journal of biological chemistry 2007;282(7):4253-64.
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2007: De Martelaere Kim; Lintermans Béatrice; Haegeman Guy; Vanhoenacker Peter
Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k.
Cellular signalling 2007;19(2):278-88.
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2006: Van Craenenbroeck Kathleen; Gellynck Evelien; Lintermans Béatrice; Leysen Josée E; Van Tol Hubert H M; Haegeman Guy; Vanhoenacker Peter
Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor.
Life sciences 2006;80(1):74-81.
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2006: De Bosscher K; Vanden Berghe W; Haegeman G
Cross-talk between nuclear receptors and nuclear factor kappaB.
Oncogene 2006;25(51):6868-86.
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2006: Vanden Berghe Wim; Ndlovu Matladi N; Hoya-Arias Ruben; Dijsselbloem Nathalie; Gerlo Sarah; Haegeman Guy
Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
Biochemical pharmacology 2006;72(9):1114-31.
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2006: Vanden Berghe Wim; Dijsselbloem Nathalie; Vermeulen Linda; Ndlovu 'matladi N; Boone Elke; Haegeman Guy
Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity.
Cancer research 2006;66(9):4852-62.
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2006: Vermeulen Linda; Vanden Berghe Wim; Haegeman Guy
Regulation of NF-kappaB transcriptional activity.
Cancer treatment and research 2006;130():89-102.
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2005: Van Craenenbroeck Kathleen; De Bosscher Karolien; Vanden Berghe Wim; Vanhoenacker Peter; Haegeman Guy
Role of glucocorticoids in dopamine-related neuropsychiatric disorders.
Molecular and cellular endocrinology 2005;245(1-2):10-22.
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2005: De Bosscher Karolien; Vanden Berghe Wim; Beck Ilse M E; Van Molle Wim; Hennuyer Nathalie; Hapgood Janet; Libert Claude; Staels Bart; Louw Ann; Haegeman Guy
A fully dissociated compound of plant origin for inflammatory gene repression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15827-32.
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2005: Aksoy Ezra; Vanden Berghe Wim; Detienne Sophie; Amraoui Zoulikha; Fitzgerald Kathrine A; Haegeman Guy; Goldman Michel; Willems Fabienne
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.
European journal of immunology 2005;35(7):2200-9.
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2005: Todorov Vladimir T; Völkl Simon; Friedrich Jürgen; Kunz-Schughart Leoni A; Hehlgans Thomas; Vermeulen Linda; Haegeman Guy; Schmitz M Lienhard; Kurtz Armin
Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}.
The Journal of biological chemistry 2005;280(26):24356-62.
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2005: de Haij Simone; Bakker Astrid C; van der Geest Reinier N; Haegeman Guy; Vanden Berghe Wim; Aarbiou Jamil; Daha Mohamed R; van Kooten Cees
NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase.
Journal of the American Society of Nephrology : JASN 2005;16(6):1603-11.
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2004: De Naeyer An; Vanden Berghe Wim; Pocock Victoria; Milligan Stuart; Haegeman Guy; De Keukeleire Denis
Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens.
Journal of natural products 2004;67(11):1829-32.
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2004: Aguilera Cristina; Hoya-Arias Ruben; Haegeman Guy; Espinosa Lluís; Bigas Anna
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16537-42.
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2004: Dijsselbloem Nathalie; Vanden Berghe Wim; De Naeyer An; Haegeman Guy
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy.
Biochemical pharmacology 2004;68(6):1171-85.
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2004: Koubovec Dominique; Berghe Wim Vanden; Vermeulen Linda; Haegeman Guy; Hapgood Janet Patricia
Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells.
Molecular and cellular endocrinology 2004;221(1-2):75-85.
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2004: De Ketelaere Adelheid; Vermeulen Linda; Vialard Jorge; Van De Weyer Inez; Van Wauwe Jean; Haegeman Guy; Moelans Inge
Involvement of GSK-3beta in TWEAK-mediated NF-kappaB activation.
FEBS letters 2004;566(1-3):60-4.
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2004: Brouckaert Greet; Kalai Michael; Krysko Dmitri V; Saelens Xavier; Vercammen Dominique; Ndlovu 'Matladi; Haegeman Guy; D'Herde Katharina; Vandenabeele Peter
Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production.
Molecular biology of the cell 2004;15(3):1089-100.
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2003: Van Craenenbroeck Kathleen; Vanhoenacker Peter; Roman Inge; Haegeman Guy
Orientation-dependent gene expression with Epstein-Barr virus-derived vectors.
FEBS letters 2003;555(3):489-94.
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2003: De Bosscher Karolien; Vanden Berghe Wim; Haegeman Guy
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.
Endocrine reviews 2003;24(4):488-522.
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2003: Vermeulen Linda; De Wilde Gert; Van Damme Petra; Vanden Berghe Wim; Haegeman Guy
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
The EMBO journal 2003;22(6):1313-24.
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2003: Devos Sabrina; De Bosscher Karolien; Staels Bart; Bauer Ellinor; Roels Frank; Berghe WimVanden; Haegeman Guy; Hooghe Robert; Hooghe-Peters Elisabeth L
Inhibition of cytokine production by the herbicide atrazine. Search for nuclear receptor targets.
Biochemical pharmacology 2003;65(2):303-8.
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2003: Vanden Berghe Wim; Vermeulen Linda; Delerive Philippe; De Bosscher Karolien; Staels Bart; Haegeman Guy
A paradigm for gene regulation: inflammation, NF-kappaB and PPAR.
Advances in experimental medicine and biology 2003;544():181-96.
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2002: Vermeulen Linda; De Wilde Gert; Notebaert Sofie; Vanden Berghe Wim; Haegeman Guy
Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.
Biochemical pharmacology 2002;64(5-6):963-70.
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2002: Delerive Philippe; De Bosscher Karolien; Vanden Berghe Wim; Fruchart Jean-Charles; Haegeman Guy; Staels Bart
DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1029-39.
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2002: Vanden Berghe W; De Bosscher K; Vermeulen L; De Wilde G; Haegeman G
Induction and repression of NF-kappa B-driven inflammatory genes.
Ernst Schering Research Foundation workshop 2002;(40):233-78.
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2001: De Wilde G; Mertens N; Boone E; De Vreese B; Van Beeumen J; Fiers W; Haegeman G
Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.
Protein expression and purification 2001;23(2):226-32.
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2001: Van Craenenbroeck K; Vanhoenacker P; Leysen J E; Haegeman G
Evaluation of the tetracycline- and ecdysone-inducible systems for expression of neurotransmitter receptors in mammalian cells.
The European journal of neuroscience 2001;14(6):968-76.
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2001: De Wilde G; Murray-Rust J; Boone E; Olerenshaw D; McDonald N Q; Ibanez C; Haegeman G; Wollmer A; Federwisch M
Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.
European journal of biochemistry / FEBS 2001;268(5):1382-91.
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2001: De Bosscher K; Vanden Berghe W; Haegeman G
Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators.
Molecular endocrinology (Baltimore, Md.) 2001;15(2):219-27.
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2000: Boone E; Vanden Berghe T; Van Loo G; De Wilde G; De Wael N; Vercammen D; Fiers W; Haegeman G; Vandenabeele P
Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.
The Journal of biological chemistry 2000;275(48):37596-603.
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2000: Vanden Berghe W; Vermeulen L; De Wilde G; De Bosscher K; Boone E; Haegeman G
Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.
Biochemical pharmacology 2000;60(8):1185-95.
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2000: Van Craenenbroeck K; Vanhoenacker P; Haegeman G
Episomal vectors for gene expression in mammalian cells.
European journal of biochemistry / FEBS 2000;267(18):5665-78.
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2000: De Bosscher K; Vanden Berghe W; Haegeman G
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors.
Journal of neuroimmunology 2000;109(1):16-22.
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2000: Van Craenenbroeck K; Vanhoenacker P; Duchau H; Haegeman G
Molecular integrity and usefulness of episomal expression vectors derived from BK and Epstein-Barr virus.
Gene 2000;253(2):293-301.
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2000: De Bosscher K; Vanden Berghe W; Vermeulen L; Plaisance S; Boone E; Haegeman G
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3919-24.
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2000: Vanhoenacker P; Haegeman G; Leysen J E
5-HT7 receptors: current knowledge and future prospects.
Trends in pharmacological sciences 2000;21(2):70-7.
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1999: Vanden Berghe W; De Bosscher K; Boone E; Plaisance S; Haegeman G
The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.
The Journal of biological chemistry 1999;274(45):32091-8.
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1999: Delerive P; De Bosscher K; Besnard S; Vanden Berghe W; Peters J M; Gonzalez F J; Fruchart J C; Tedgui A; Haegeman G; Staels B
Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1.
The Journal of biological chemistry 1999;274(45):32048-54.
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1999: Vanden Berghe W; Francesconi E; De Bosscher K; Resche-Rigon M; Haegeman G
Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism.
Molecular pharmacology 1999;56(4):797-806.
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1999: Heyninck K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
The Journal of cell biology 1999;145(7):1471-82.
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1999: Verhasselt V; Vanden Berghe W; Vanderheyde N; Willems F; Haegeman G; Goldman M
N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2569-74.
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1999: Peppelenbosch M; Boone E; Jones G E; van Deventer S J; Haegeman G; Fiers W; Grooten J; Ridley A J
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):837-45.
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1998: Vanhoenacker P; Van den Bogerd I; Gommeren W; Luyten W H; Leysen J E; Haegeman G
Efficient expression of neurotransmitter receptors in mammalian cells: use of inducible expression systems.
Annals of the New York Academy of Sciences 1998;861():236-7.
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1998: Boone E; Vandevoorde V; De Wilde G; Haegeman G
Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor.
FEBS letters 1998;441(2):275-80.
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1998: Lesage A S; Wouters R; Van Gompel P; Heylen L; Vanhoenacker P; Haegeman G; Luyten W H; Leysen J E
Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.
British journal of pharmacology 1998;123(8):1655-65.
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1998: De Vos K; Goossens V; Boone E; Vercammen D; Vancompernolle K; Vandenabeele P; Haegeman G; Fiers W; Grooten J
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
The Journal of biological chemistry 1998;273(16):9673-80.
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1998: Vanden Berghe W; Plaisance S; Boone E; De Bosscher K; Schmitz M L; Fiers W; Haegeman G
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.
The Journal of biological chemistry 1998;273(6):3285-90.
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1998: Decoster E; Vanhaesebroeck B; Boone E; Plaisance S; De Vos K; Haegeman G; Grooten J; Fiers W
Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
The Journal of biological chemistry 1998;273(6):3271-7.
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1997: De Bosscher K; Schmitz M L; Vanden Berghe W; Plaisance S; Fiers W; Haegeman G
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13504-9.
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1997: Decoster E; Vandevoorde V; Beyaert R; Haegeman G; Fiers W
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.
FEBS letters 1997;416(2):183-6.
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1997: Plaisance S; Vanden Berghe W; Boone E; Fiers W; Haegeman G
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.
Molecular and cellular biology 1997;17(7):3733-43.
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1997: Vandevoorde V; Haegeman G; Fiers W
Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.
The Journal of cell biology 1997;137(7):1627-38.
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1997: Vanhoenacker P; Gommeren W; Luyten W H; Leysen J E; Haegeman G
Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system.
Receptors & channels 1997;5(3-4):125-37.
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1996: Leysen J E; Gommeren W; Heylen L; Luyten W H; Van de Weyer I; Vanhoenacker P; Haegeman G; Schotte A; Van Gompel P; Wouters R; Lesage A S
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.
Molecular pharmacology 1996;50(6):1567-80.
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1996: Beyaert R; Cuenda A; Vanden Berghe W; Plaisance S; Lee J C; Haegeman G; Cohen P; Fiers W
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
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1995: Fiers W; Beyaert R; Boone E; Cornelis S; Declercq W; Decoster E; Denecker G; Depuydt B; De Valck D; De Wilde G; Goossens V; Grooten J; Haegeman G; Heyninck K; Penning L; Plaisance S; Vancompernolle K; Van Criekinge W; Vandenabeele P; Vanden Berghe W; Van de Craen M; Vandevoorde V; Vercammen D
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
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1994: Vanhoenacker P; Fiers W; Haegeman G
Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.
European cytokine network 1994;5(3):283-91.
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1993: Schulze-Osthoff K; Beyaert R; Vandevoorde V; Haegeman G; Fiers W
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
The EMBO journal 1993;12(8):3095-104.
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1993: Beyaert R; Vanhaesebroeck B; Heyninck K; Boone E; De Valck D; Schulze-Osthoff K; Haegeman G; Van Roy F; Fiers W
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
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1993: Patestos N P; Haegeman G; Vandevoorde V; Fiers W
Activation of the nuclear factor kappa B is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression.
Biochimie 1993;75(11):1007-18.
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1992: Van Lint J; Agostinis P; Vandevoorde V; Haegeman G; Fiers W; Merlevede W; Vandenheede J R
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
The Journal of biological chemistry 1992;267(36):25916-21.
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1992: Vandevoorde V; Haegeman G; Fiers W
TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells.
FEBS letters 1992;302(3):235-8.
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1992: Patestos N P; Haegeman G; Fiers W
TNF-induced, cytotoxicity-linked IL6 gene expression in L929 cells may require factors other than NF-kappa B.
Biochemical Society transactions 1992;20(1):80S.
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1991: Vandevoorde V; Haegeman G; Fiers W
Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells.
Biochemical and biophysical research communications 1991;178(3):993-1001.
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1991: Guisez Y; Tison B; Vandekerckhove J; Demolder J; Bauw G; Haegeman G; Fiers W; Contreras R
Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1991;198(1):217-22.
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1987: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Haegeman G; Suffys P; Tavernier J; Vandenabeele P; Vanhaesebroeck B; Van Ostade X
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins.
Immunology letters 1987;16(3-4):219-26.
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1987: Poupart P; Vandenabeele P; Cayphas S; Van Snick J; Haegeman G; Kruys V; Fiers W; Content J
B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF).
The EMBO journal 1987;6(5):1219-24.
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