FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jesper Haeggström

Research Profile

Chemicals & Drugs

Concepts & Ideas

Co-author Network

Publications

TOP 3
J Sun; Birgitta Agerberth; Barbro Dahlén; Jesper Z Haeggström
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.
Jesper Z Haeggström; Mats Hamberg
Resolving resolvins.
Susanna L Lundström; Gunnar Nilsson; Rohit Saluja; Mikael Adner; Jesper Z Haeggström; Craig E Wheelock
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jesper Haeggström (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: J Sun; Birgitta Agerberth; Barbro Dahlén; Jesper Z Haeggström
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.
Allergy 2013;68(3):304-11.
2013: Jesper Z Haeggström; Mats Hamberg
Resolving resolvins.
Chemistry & biology 2013;20(2):138-40.
2013: Susanna L Lundström; Gunnar Nilsson; Rohit Saluja; Mikael Adner; Jesper Z Haeggström; Craig E Wheelock
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations.
Journal of lipid research 2013;54(1):116-26.
2012: M Dolores Salvado; Arántzazu Alfranca; Jesper Z Haeggström; Juan Miguel Redondo
Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2.
Trends in molecular medicine 2012;18(4):233-43.
2012: Agnes Rinaldo-Matthis; Anders Wetterholm; Shabbir Ahmad; Peter Lachmann; Ralf Morgenstern; Jesper Z Haeggström
Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C₄ synthase.
Biochemistry 2012;51(4):848-56.
2012: Antonio Di Gennaro; Jesper Z Haeggström
The leukotrienes: immune-modulating lipid mediators of disease.
Advances in immunology 2012;116():51-92.
2012: Elena Nobili; M Dolores Salvado; Luigi Sironi; Elena Tremoli; Anders Wetterholm; Laura Castiglioni; Lasse Folkersen; Jesper Z Haeggström; Göran K Hansson; Jens Kastrup; Anders Gabrielsen
Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.
PloS one 2012;7(7):e41786.
2012: Susanna L Lundström; Sarah Thunberg; Marianne van Hage; Anders Eklund; Guro Gafvelin; Reidar Grönneberg; Johan Grunewald; Jesper Z Haeggström; Bruce D Hammock; Henrik J Källberg; Jun Yang; Asa M Wheelock; Craig E Wheelock
Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.
PloS one 2012;7(3):e33780.
2011: Jesper Z Haeggström; Colin D Funk
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.
Chemical reviews 2011;111(10):5866-98.
2011: Susanna L Lundström; David Balgoma; Sven-Erik Dahlén; Jesper Z Haeggström; Asa M Wheelock; Craig E Wheelock
Lipid mediator profiling in pulmonary disease.
Current pharmaceutical biotechnology 2011;12(7):1026-52.
2011: Min Wan; Catherine Godson; Patrick J Guiry; Birgitta Agerberth; Jesper Z Haeggström
Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(5):1697-705.
2011: Karl Gertow; Elena Nobili; Lasse Folkersen; John William Newman; Theresa L Pedersen; Johan Ekstrand; Jesper Swedenborg; Hartmut Kühn; Craig E Wheelock; Göran K Hansson; Ulf Hedin; Jesper Z Haeggström; Anders Gabrielsen
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.
Atherosclerosis 2011;215(2):411-6.
2011: Julia Esser; Ulf Gehrmann; M Dolores Salvado; Anders Wetterholm; Jesper Z Haeggström; Bengt Samuelsson; Susanne Gabrielsson; Annika Scheynius; Olof Rådmark
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(4):1417-27.
2011: Anne-Sofie Johansson; Jesper Z Haeggström; Jan Palmblad
Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells: Effects on calcium transients, adhesive events and mediator release.
Prostaglandins, leukotrienes, and essential fatty acids 2011;84(3-4):109-12.
2011: Charlotte Helgstrand; Mahmudul Hasan; Hüseyin Uysal; Jesper Z Haeggström; Marjolein M G M Thunnissen
A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding.
Journal of molecular biology 2011;406(1):120-34.
2011: Susanna L Lundström; Malin Nording; Magnus Sköld; Magnus Svartengren; Anders Eklund; Johan Grunewald; Jesper Z Haeggström; Bruce D Hammock; Anna Klepczynska-Nyström; Britt-Marie Larsson; Bettina Levänen; Asa M Wheelock; Craig E Wheelock
Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure.
PloS one 2011;6(8):e23864.
2010: Agnes Rinaldo-Matthis; Anders Wetterholm; Daniel Martinez Molina; Johanna Holm; Damian Niegowski; Eva Ohlson; Pär Nordlund; Ralf Morgenstern; Jesper Z Haeggström
Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
The Journal of biological chemistry 2010;285(52):40771-6.
2010: Antonio Di Gennaro; Dick Wågsäter; Mikko I Mäyränpää; Anders Gabrielsen; Jesper Swedenborg; Anders Hamsten; Bengt Samuelsson; Per Eriksson; Jesper Z Haeggström
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(49):21093-7.
2010: Anne-Sofie Johansson; Jesper Z Haeggström; Kjell Hultenby; Jan Palmblad
Subcellular localization of leukotriene receptors in human endothelial cells.
Experimental cell research 2010;316(17):2790-6.
2010: Fredrik Tholander; Bernard-Pierre Roques; Marie-Claude Fournié-Zaluski; Marjolein M G M Thunnissen; Jesper Z Haeggström
Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors.
FEBS letters 2010;584(15):3446-51.
2010: Anders Gabrielsen; Hong Qiu; Magnus Bäck; Mats Hamberg; Anne-Louise Hemdahl; Hanna Agardh; Lasse Folkersen; Jesper Swedenborg; Ulf Hedin; Gabrielle Paulsson-Berne; Jesper Z Haeggström; Göran K Hansson
Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion.
Journal of molecular medicine (Berlin, Germany) 2010;88(8):795-806.
2010: Agnes Rinaldo-Matthis; Jesper Z Haeggström
Structures and mechanisms of enzymes in the leukotriene cascade.
Biochimie 2010;92(6):676-81.
2010: Jesper Z Haeggström; Agnes Rinaldo-Matthis; Craig E Wheelock; Anders Wetterholm
Advances in eicosanoid research, novel therapeutic implications.
Biochemical and biophysical research communications 2010;396(1):135-9.
2010: Diego Diez; Asa M Wheelock; Susumu Goto; Jesper Z Haeggström; Gabrielle Paulsson-Berne; Göran K Hansson; Ulf Hedin; Anders Gabrielsen; Craig E Wheelock
The use of network analyses for elucidating mechanisms in cardiovascular disease.
Molecular bioSystems 2010;6(2):289-304.
2009: Lasse Folkersen; Diego Diez; Craig E Wheelock; Jesper Z Haeggström; Susumu Goto; Per Eriksson; Anders Gabrielsen
GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome.
Bioinformatics (Oxford, England) 2009;25(15):1978-9.
2009: M Dolores Salvado; Arántzazu Alfranca; Amelia Escolano; Jesper Z Haeggström; Juan Miguel Redondo
COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1131-7.
2009: Craig E Wheelock; Asa M Wheelock; Shuichi Kawashima; Diego Diez; Minoru Kanehisa; Marjan van Erk; Robert Kleemann; Jesper Z Haeggström; Susumu Goto
Systems biology approaches and pathway tools for investigating cardiovascular disease.
Molecular bioSystems 2009;5(6):588-602.
2009: Antonio Di Gennaro; Ellinor Kenne; Min Wan; Oliver Soehnlein; Lennart Lindbom; Jesper Z Haeggström
Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(6):1750-7.
2009: Tove Hammarberg; Mats Hamberg; Anders Wetterholm; Henrik Hansson; Bengt Samuelsson; Jesper Z Haeggström
Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha.
The Journal of biological chemistry 2009;284(1):301-5.
2009: Susanna L Lundström; Fabio L D'Alexandri; Kasem Nithipatikom; Jesper Z Haeggström; Asa M Wheelock; Craig E Wheelock
HPLC/MS/MS-based approaches for detection and quantification of eicosanoids.
Methods in molecular biology (Clifton, N.J.) 2009;579():161-87.
2008: Adrienne L Huston; Jesper Z Haeggström; Georges Feller
Cold adaptation of enzymes: structural, kinetic and microcalorimetric characterizations of an aminopeptidase from the Arctic psychrophile Colwellia psychrerythraea and of human leukotriene A(4) hydrolase.
Biochimica et biophysica acta 2008;1784(11):1865-72.
2008: Baldur Sveinbjörnsson; Agnes Rasmuson; Ninib Baryawno; Min Wan; Ingvild Pettersen; Frida Ponthan; Abiel Orrego; Jesper Z Haeggström; John Inge Johnsen; Per Kogner
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3525-36.
2008: Fredrik Tholander; Ayumo Muroya; Bernard-Pierre Roques; Marie-Claude Fournié-Zaluski; Marjolein M G M Thunnissen; Jesper Z Haeggström
Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.
Chemistry & biology 2008;15(9):920-9.
2008: Anders Wetterholm; Daniel Martinez Molina; Pär Nordlund; Said Eshaghi; Jesper Z Haeggström
High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris.
Protein expression and purification 2008;60(1):1-6.
2008: Thomas A Kirkland; Marc Adler; John G Bauman; Ming Chen; Jesper Z Haeggström; Beverly King; Monica J Kochanny; Amy M Liang; Lisa Mendoza; Gary B Phillips; Marjolein Thunnissen; Lan Trinh; Marc Whitlow; Bin Ye; Hong Ye; John Parkinson; William J Guilford
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorganic & medicinal chemistry 2008;16(9):4963-83.
2008: Daniel Martinez Molina; Tobias Cornvik; Said Eshaghi; Jesper Z Haeggström; Pär Nordlund; Marina Ignatushchenko Sabet
Engineering membrane protein overproduction in Escherichia coli.
Protein science : a publication of the Protein Society 2008;17(4):673-80.
2008: Hong Qiu; Klas Strååt; Afsar Rahbar; Min Wan; Cecilia Söderberg-Nauclér; Jesper Z Haeggström
Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells.
The Journal of experimental medicine 2008;205(1):19-24.
2007: Min Wan; Alan Sabirsh; Anders Wetterholm; Birgitta Agerberth; Jesper Z Haeggström
Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2897-905.
2007: Daniel Martinez Molina; Anders Wetterholm; Andreas Kohl; Andrew A McCarthy; Damian Niegowski; Eva Ohlson; Tove Hammarberg; Said Eshaghi; Jesper Z Haeggström; Pär Nordlund
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.
Nature 2007;448(7153):613-6.
2007: Fredrik Tholander; Jesper Z Haeggström
Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase.
Proteins 2007;67(4):1113-8.
2007: Magnus Bäck; Kiyoto Sakata; Hong Qiu; Jesper Z Haeggström; Sven-Erik Dahlén
Endothelium-dependent vascular responses induced by leukotriene B4.
Prostaglandins & other lipid mediators 2007;83(3):209-12.
2007: Jesper Z Haeggström; Fredrik Tholander; Anders Wetterholm
Structure and catalytic mechanisms of leukotriene A4 hydrolase.
Prostaglandins & other lipid mediators 2007;83(3):198-202.
2006: Sébastien Albrecht; Albert Defoin; Emmanuel Salomon; Céline Tarnus; Anders Wetterholm; Jesper Z Haeggström
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.
Bioorganic & medicinal chemistry 2006;14(21):7241-57.
2006: Hong Qiu; Anders Gabrielsen; Hanna E Agardh; Min Wan; Anders Wetterholm; Chi-Huey Wong; Ulf Hedin; Jesper Swedenborg; Göran K Hansson; Bengt Samuelsson; Gabrielle Paulsson-Berne; Jesper Z Haeggström
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8161-6.
2006: Alan Sabirsh; Robert P Bywater; Jesper Bristulf; Christer Owman; Jesper Z Haeggström
Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1.
Biochemistry 2006;45(18):5733-44.
2006: Hong Qiu; Anne-Sofie Johansson; Mattias Sjöström; Min Wan; Oliver Schröder; Jan Palmblad; Jesper Z Haeggström
Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6913-8.
2006: Oliver Schröder; Yulyana Yudina; Alan Sabirsh; Nadine Zahn; Jesper Z Haeggström; Jürgen Stein
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
Journal of lipid research 2006;47(5):1071-80.
2005: Alan Sabirsh; Jesper Bristulf; Ulf Karlsson; Christer Owman; Jesper Z Haeggström
Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology.
Prostaglandins, leukotrienes, and essential fatty acids 2005;73(6):431-40.
2005: Fredrik Tholander; Filippa Kull; Eva Ohlson; Jawed Shafqat; Marjolein M G M Thunnissen; Jesper Z Haeggström
Leukotriene A4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(39):33477-86.
2005: Alan Sabirsh; Anders Wetterholm; Jesper Bristulf; Hakon Leffler; Jesper Z Haeggström; Christer Owman
Fluorescent leukotriene B4: potential applications.
Journal of lipid research 2005;46(6):1339-46.
2005: Oliver Schröder; Mattias Sjöström; Hong Qiu; Per-Johan Jakobsson; Jesper Z Haeggström
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis.
Cellular and molecular life sciences : CMLS 2005;62(1):87-94.
2004: Jesper Z Haeggström
Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis.
The Journal of biological chemistry 2004;279(49):50639-42.
2004: Rossella Ramires; Maria Filomena Caiaffa; Alfredo Tursi; Jesper Z Haeggström; Luigi Macchia
Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast.
Biochemical and biophysical research communications 2004;324(2):815-21.
2004: Santosh Nigam; Shankarnarayanan Patabhiraman; Roberto Ciccoli; Ganchimeg Ishdorj; Kristin Schwarz; Branka Petrucev; Hartmut Kühn; Jesper Z Haeggström
The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity.
The Journal of biological chemistry 2004;279(28):29023-30.
2004: Magnus Bäck; Hong Qiu; Jesper Z Haeggström; Kiyoto Sakata
Leukotriene B4 is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor.
American journal of physiology. Heart and circulatory physiology 2004;287(1):H419-24.
2004: Peter C Rudberg; Fredrik Tholander; Martina Andberg; Marjolein M G M Thunnissen; Jesper Z Haeggström
Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.
The Journal of biological chemistry 2004;279(26):27376-82.
2003: Oliver Schröder; Mattias Sjöström; Hong Qiu; Jürgen Stein; Per-Johan Jakobsson; Jesper Z Haeggström
Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs.
Biochemical and biophysical research communications 2003;312(2):271-6.
2003: Mattias Sjöström; Anne-Sofie Johansson; Oliver Schröder; Hong Qiu; Jan Palmblad; Jesper Z Haeggström
Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):e37-41.
2003: Björn Andersson; Filippa Kull; Jesper Z Haeggström; Marjolein M G M Thunnissen
Crystallization and X-ray diffraction data analysis of leukotriene A4 hydrolase from Saccharomyces cerevisiae.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 6):1093-5.
2002: Marjolein M G M Thunnissen; Björn Andersson; Bengt Samuelsson; Chi-Huey Wong; Jesper Z Haeggström
Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(12):1648-50.
2002: Jesper Z Haeggström; Filippa Kull; Peter C Rudberg; Fredrik Tholander; Marjolein M G M Thunnissen
Leukotriene A4 hydrolase.
Prostaglandins & other lipid mediators 2002;68-69():495-510.
2002: Jesper Z Haeggström; Pär Nordlund; Marjolein M G M Thunnissen
Functional properties and molecular architecture of leukotriene A4 hydrolase, a pivotal catalyst of chemotactic leukotriene formation.
TheScientificWorldJournal 2002;2():1734-49.
2002: Mattias Sjöström; Per-Johan Jakobsson; Mikael Juremalm; Ahmed Ahmed; Gunnar Nilsson; Luigi Macchia; Jesper Z Haeggström
Human mast cells express two leukotriene C(4) synthase isoenzymes and the CysLT(1) receptor.
Biochimica et biophysica acta 2002;1583(1):53-62.
2002: Jesper Z Haeggström; Anders Wetterholm
Enzymes and receptors in the leukotriene cascade.
Cellular and molecular life sciences : CMLS 2002;59(5):742-53.
2002: Peter C Rudberg; Fredrik Tholander; Marjolein M G M Thunnissen; Jesper Z Haeggström
Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.
The Journal of biological chemistry 2002;277(2):1398-404.
2002: Sergueï O Fetissov; O Schröder; P-J Jakobsson; Bengt Samuelsson; Jesper Z Haeggström; Tomas Hökfelt
Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system.
Neuroscience 2002;115(3):891-7.
2001: Filippa Kull; Eva Ohlson; B Lind; Jesper Z Haeggström
Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues.
Biochemistry 2001;40(42):12695-703.
2001: Mattias Sjöström; Per-Johan Jakobsson; M Heimburger; Jan Palmblad; Jesper Z Haeggström
Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.
European journal of biochemistry / FEBS 2001;268(9):2578-86.
2001: Marjolein M G M Thunnissen; Pär Nordlund; Jesper Z Haeggström
Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nature structural biology 2001;8(2):131-5.
2000: Jesper Z Haeggström
Structure, function, and regulation of leukotriene A4 hydrolase.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S25-31.
2000: Martina Andberg; Anders Wetterholm; J F Medina; Jesper Z Haeggström
Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin.
The Biochemical journal 2000;345 Pt 3():621-5.
2000: Jesper Z Haeggström; Anders Wetterholm
Leukotriene-A4 hydrolase: probing the active sites and catalytic mechanisms by site-directed mutagenesis.
Ernst Schering Research Foundation workshop 2000;(31):85-96.
1999: Filippa Kull; Eva Ohlson; Jesper Z Haeggström
Cloning and characterization of a bifunctional leukotriene A(4) hydrolase from Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(49):34683-90.
1999: T Colamorea; R Di Paola; F Macchia; M C Guerrese; Alfredo Tursi; J H Butterfield; Maria Filomena Caiaffa; Jesper Z Haeggström; Luigi Macchia
5-Lipoxygenase upregulation by dexamethasone in human mast cells.
Biochemical and biophysical research communications 1999;265(3):617-24.
1999: Jesper Z Haeggström
Leukotriene A4 hydrolase and the committed step in leukotriene B4 biosynthesis.
Clinical reviews in allergy & immunology 1999;17(1-2):111-31.
1999: Martina Andberg; Mats Hamberg; Jesper Z Haeggström
Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4.
Advances in experimental medicine and biology 1999;469():319-25.
1998: F Strömberg-Kull; Jesper Z Haeggström
Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes.
FEBS letters 1998;433(3):219-22.
1998: M J Mueller; Martina Andberg; Jesper Z Haeggström
Analysis of the molecular mechanism of substrate-mediated inactivation of leukotriene A4 hydrolase.
The Journal of biological chemistry 1998;273(19):11570-5.
1997: Martina Andberg; Mats Hamberg; Jesper Z Haeggström
Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism.
The Journal of biological chemistry 1997;272(37):23057-63.
1997: F Strömberg; U Rosenqvist; Sven-Erik Dahlén; Jesper Z Haeggström
Leukotriene A4 hydrolase activity in Xenopus laevis.
Advances in experimental medicine and biology 1997;433():375-8.
1997: Martina Andberg; Anders Wetterholm; Jesper Z Haeggström
Mutation of Tyr-383 in leukotriene A4 hydrolase: effects on enzyme activities.
Advances in experimental medicine and biology 1997;433():149-52.
1997: Anders Wetterholm; Jesper Z Haeggström
Leukotriene A4 hydrolase: differential inhibition of the catalytic activities by divalent cations.
Advances in experimental medicine and biology 1997;400A():153-7.
1997: F Strömberg; Jesper Z Haeggström
Enzymatic conversion of leukotriene A4 into 5(S),12(R)-diHETE in frog tissues.
Advances in experimental medicine and biology 1997;407():555-9.
1997: Anders Wetterholm; M J Mueller; M Blomster; Bengt Samuelsson; Jesper Z Haeggström
Studies on the active site of leukotriene A4 hydrolase.
Advances in experimental medicine and biology 1997;407():1-7.
1996: M J Mueller; Martina Andberg; Bengt Samuelsson; Jesper Z Haeggström
Leukotriene A4 hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A4 into an isomer of leukotriene B4.
The Journal of biological chemistry 1996;271(40):24345-8.
1996: M J Mueller; M Blomster; Udo Oppermann; Hans Jörnvall; Bengt Samuelsson; Jesper Z Haeggström
Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5931-5.
1995: J H Hogg; I R Ollmann; Jesper Z Haeggström; Anders Wetterholm; Bengt Samuelsson; Chi-Huey Wong
Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase.
Bioorganic & medicinal chemistry 1995;3(10):1405-15.
1995: Anders Wetterholm; Jesper Z Haeggström; Bengt Samuelsson; W Yuan; B Munoz; Chi-Huey Wong
Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes.
The Journal of pharmacology and experimental therapeutics 1995;275(1):31-7.
1995: M J Mueller; Anders Wetterholm; M Blomster; Hans Jörnvall; Bengt Samuelsson; Jesper Z Haeggström
Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8383-7.
1995: M Blomster; Anders Wetterholm; M J Mueller; Jesper Z Haeggström
Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase.
European journal of biochemistry / FEBS 1995;231(3):528-34.
1995: I R Ollmann; J H Hogg; B Muñoz; Jesper Z Haeggström; Bengt Samuelsson; Chi-Huey Wong
Investigation of the inhibition of leukotriene A4 hydrolase.
Bioorganic & medicinal chemistry 1995;3(7):969-95.
1995: Luigi Macchia; M Hamberg; Maria Kumlin; J H Butterfield; Jesper Z Haeggström
Arachidonic acid metabolism in the human mast cell line HMC-1: 5-lipoxygenase gene expression and biosynthesis of thromboxane.
Biochimica et biophysica acta 1995;1257(1):58-74.
1995: M J Mueller; Bengt Samuelsson; Jesper Z Haeggström
Chemical modification of leukotriene A4 hydrolase. Indications for essential tyrosyl and arginyl residues at the active site.
Biochemistry 1995;34(11):3536-43.
1995: Anders Wetterholm; Luigi Macchia; Jesper Z Haeggström
Metal inhibition of LTA4 hydrolase and cellular 5-lipoxygenase activity.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():179-81.
1994: Anders Wetterholm; Luigi Macchia; Jesper Z Haeggström
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
Archives of biochemistry and biophysics 1994;311(2):263-71.
1994: Jesper Z Haeggström; Anders Wetterholm; J F Medina; Bengt Samuelsson
Novel structural and functional properties of leukotriene A4 hydrolase. Implications for the development of enzyme inhibitors.
Advances in prostaglandin, thromboxane, and leukotriene research 1994;22():3-12.
1993: T Watanabe; Jesper Z Haeggström
Rat 12-lipoxygenase: mutations of amino acids implicated in the positional specificity of 15- and 12-lipoxygenases.
Biochemical and biophysical research communications 1993;192(3):1023-9.
1993: T Watanabe; J F Medina; Jesper Z Haeggström; O Rådmark; Bengt Samuelsson
Molecular cloning of a 12-lipoxygenase cDNA from rat brain.
European journal of biochemistry / FEBS 1993;212(2):605-12.
1993: Jesper Z Haeggström; Anders Wetterholm; J F Medina; Bengt Samuelsson
Leukotriene A4 hydrolase: structural and functional properties of the active center.
Journal of lipid mediators 1993;6(1-3):1-13.
1993: W Yuan; B Munoz; Chi-Huey Wong; Jesper Z Haeggström; Anders Wetterholm; Bengt Samuelsson
Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.
Journal of medicinal chemistry 1993;36(2):211-20.
1992: Anders Wetterholm; J F Medina; O Rådmark; R Shapiro; Jesper Z Haeggström; Bert L Vallee; Bengt Samuelsson
Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9141-5.
1992: Anders Wetterholm; Jesper Z Haeggström
Leukotriene A4 hydrolase: an anion activated peptidase.
Biochimica et biophysica acta 1992;1123(3):275-81.
1991: Anders Wetterholm; J F Medina; O Rådmark; R Shapiro; Jesper Z Haeggström; Bert L Vallee; Bengt Samuelsson
Recombinant mouse leukotriene A4 hydrolase: a zinc metalloenzyme with dual enzymatic activities.
Biochimica et biophysica acta 1991;1080(2):96-102.
1991: J F Medina; Anders Wetterholm; O Rådmark; R Shapiro; Jesper Z Haeggström; Bert L Vallee; Bengt Samuelsson
Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7620-4.
1991: B Odlander; Hans-Erik Claesson; T Bergman; O Rådmark; H Jörnvall; Jesper Z Haeggström
Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme.
Archives of biochemistry and biophysics 1991;287(1):167-74.
1991: J F Medina; O Rådmark; C D Funk; Jesper Z Haeggström
Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA.
Biochemical and biophysical research communications 1991;176(3):1516-24.
1991: Bengt Samuelsson; Jesper Z Haeggström; Anders Wetterholm
Leukotriene biosynthesis.
Annals of the New York Academy of Sciences 1991;629():89-99.
1991: O Rådmark; J F Medina; L Macchia; C Barrios; C D Funk; O Larsson; Jesper Z Haeggström
Leukotriene A4-hydrolase in two human cell lines.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():41-4.
1991: B Odlander; Jesper Z Haeggström; T Bergman; O Rådmark; Anders Wetterholm; Hans-Erik Claesson
Leukotriene A4 hydrolase in the B-lymphocytic cell line Raji.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():133-6.
1991: Hans-Erik Claesson; Jesper Z Haeggström; B Odlander; J F Medina; Anders Wetterholm; Per-Johan Jakobsson; O Rådmark
The role of leukotriene A4 hydrolase in cells and tissues lacking 5-lipoxygenase.
Advances in experimental medicine and biology 1991;314():307-15.
1990: Jesper Z Haeggström; Anders Wetterholm; Bert L Vallee; Bengt Samuelsson
Leukotriene A4 hydrolase: an epoxide hydrolase with peptidase activity.
Biochemical and biophysical research communications 1990;173(1):431-7.
1990: Jesper Z Haeggström; Anders Wetterholm; R Shapiro; Bert L Vallee; Bengt Samuelsson
Leukotriene A4 hydrolase: a zinc metalloenzyme.
Biochemical and biophysical research communications 1990;172(3):965-70.
1990: J F Medina; C Barrios; C D Funk; O Larsson; Jesper Z Haeggström; O Rådmark
Human fibroblasts show expression of the leukotriene-A4-hydrolase gene, which is increased after simian-virus-40 transformation.
European journal of biochemistry / FEBS 1990;191(1):27-31.
1990: O Rådmark; Jesper Z Haeggström
Properties of leukotriene A4-hydrolase.
Advances in prostaglandin, thromboxane, and leukotriene research 1990;20():35-45.
1989: J Y Fu; Jesper Z Haeggström; P Collins; J Meijer; O Rådmark
Leukotriene A4 hydrolase: analysis of some human tissues by radioimmunoassay.
Biochimica et biophysica acta 1989;1006(1):121-6.
1989: O Rådmark; C D Funk; J Y Fu; T Matsumoto; H Jörnvall; T Shimizu; J F Medina; Jesper Z Haeggström; Maria Kumlin; Bengt Samuelsson
Leukotriene A4-hydrolase, cloning of the human enzyme and tissue distribution in the rat.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():484-7.
1988: C Edenius; Jesper Z Haeggström; Jan Ake Lindgren
Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions.
Biochemical and biophysical research communications 1988;157(2):801-7.
1988: J F Medina; Jesper Z Haeggström; Maria Kumlin; O Rådmark
Leukotriene A4: metabolism in different rat tissues.
Biochimica et biophysica acta 1988;961(2):203-12.
1988: Jesper Z Haeggström; T Bergman; H Jörnvall; O Rådmark
Guinea-pig liver leukotriene A4 hydrolase. Purification, characterization and structural properties.
European journal of biochemistry / FEBS 1988;174(4):717-24.
1988: Anders Wetterholm; Jesper Z Haeggström; M Hamberg; J Meijer; O Rådmark
14,15-Dihydroxy-5,8,10,12-eicosatetraenoic acid. Enzymatic formation from 14,15-leukotriene A4.
European journal of biochemistry / FEBS 1988;173(3):531-6.
1988: Hans-Erik Claesson; Jesper Z Haeggström
Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4.
European journal of biochemistry / FEBS 1988;173(1):93-100.
1988: Jesper Z Haeggström; Anders Wetterholm; M Hamberg; J Meijer; R Zipkin; O Rådmark
Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: kinetics of the reaction and stereochemistry of the product.
Biochimica et biophysica acta 1988;958(3):469-76.
1987: J F Medina; Jesper Z Haeggström; Anders Wetterholm; Alf Wallin; O Rådmark
Enzymatic hydrolysis of leukotriene A4 into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid and LTB4 by mammalian kidney.
Biochemical and biophysical research communications 1987;143(2):697-703.
1987: Charles N Serhan; K C Nicolaou; S E Webber; C A Veale; Jesper Z Haeggström; T J Puustinen; Bengt Samuelsson
Stereochemistry and biosynthesis of lipoxins.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():90-3.
1987: Jesper Z Haeggström; J Meijer; O Rådmark
Enzymatic transformation of leukotriene A4 into 5,6-dihydroxy-7,9,11, 14-eicosatetraenoic acid.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():134-9.
1987: Hans-Erik Claesson; Jesper Z Haeggström
Metabolism of leukotriene A4 by human endothelial cells: evidence for leukotriene C4 and D4 formation by leukocyte-endothelial cell interaction.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():115-9.