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Guido Haenen

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Reyhan Nergiz-Ünal; Sylvia Heeneman; Marijke J E Kuijpers; Erik A L Biessen; Judith M E M Cosemans; Susanne M de Witt; Marion A H Feijge; Sonia C Garcia Caraballo; Guido R M M Haenen; Johan W M Heemskerk
Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.
Kimberly Vanhees; Jacob J Briedé; Guido R M M Haenen; Armelle Munnia; Marco Peluso; Stefan van Helden; Frederik J Van Schooten; Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Roger Godschalk
Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage.
Mohamed Moalin; Gino P F van Strijdonck; Aalt Bast; Guido R M M Haenen
Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin, 4'O-methylquercetin, has the lowest thiol reactivity.

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2013: Reyhan Nergiz-Ünal; Sylvia Heeneman; Marijke J E Kuijpers; Erik A L Biessen; Judith M E M Cosemans; Susanne M de Witt; Marion A H Feijge; Sonia C Garcia Caraballo; Guido R M M Haenen; Johan W M Heemskerk
Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.
Thrombosis research 2013;131(5):411-7.
2013: Kimberly Vanhees; Jacob J Briedé; Guido R M M Haenen; Armelle Munnia; Marco Peluso; Stefan van Helden; Frederik J Van Schooten; Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Roger Godschalk
Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage.
Free radical biology & medicine 2013;57():154-61.
2012: Mohamed Moalin; Gino P F van Strijdonck; Aalt Bast; Guido R M M Haenen
Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin, 4'O-methylquercetin, has the lowest thiol reactivity.
Journal of agricultural and food chemistry 2012;60(36):9292-7.
2012: Agnes W Boots; Kirsten Gerloff; Guido R M M Haenen; Kirstin Ledermann; Catrin Albrecht; Roger Bartholomé; Aalt Bast; Damien van Berlo; Frederik-Jan van Schooten; Roel P F Schins
Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells.
Biochimica et biophysica acta 2012;1823(7):1151-62.
2012: Nuria Mateo Anson; Youna M Hemery; Aalt Bast; Guido R M M Haenen
Optimizing the bioactive potential of wheat bran by processing.
Food & function 2012;3(4):362-75.
2011: H Jacobs; Ger H Koek; M Moalin; R Peters; J Tack; Wim J F van der Vijgh; Aalt Bast; Guido R M M Haenen
Differences in pharmacological activities of the antioxidant flavonoid monoHER in humans and mice are caused by variations in its metabolic profile.
Clinical pharmacology and therapeutics 2011;90(6):852-9.
2011: Hilde Jacobs; Mohamed Moalin; Wim J F van der Vijgh; Marike W van Gisbergen; Aalt Bast; Guido R M M Haenen
An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin.
Free radical biology & medicine 2011;51(11):2118-23.
2011: M G J Snoeijs; Lauri Vaahtera; L W Ernest van Heurn; Carine J Peutz-Kootstra; Geert Willem H Schurink; Wim A Buurman; Eva E de Vries; Guido R M M Haenen; Jaakko Parkkinen
Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation.
Transplantation 2011;92(3):296-302.
2011: Agnes W Boots; Vincent C J de Boer; Marjolein Drent; Aalt Bast; Guido R M M Haenen
Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis.
Clinical nutrition (Edinburgh, Scotland) 2011;30(4):506-12.
2011: Joost O Linschooten; Ville E Sipinen; Frederik J Van Schooten; Guido R M M Haenen; Julian Laubenthal; Diana Anderson; Adolf Baumgartner; Jacob J Briedé; Gunnar Brunborg; Eduardo Cemeli; Eleni Fthenou; Roger Godschalk
Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress.
Reproductive toxicology (Elmsford, N.Y.) 2011;32(1):106-11.
2011: Hilde Jacobs; Ron Peters; Gertjan J M den Hartog; Wim J F van der Vijgh; Aalt Bast; Guido R M M Haenen
Identification of the metabolites of the antioxidant flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside in mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(5):750-6.
2011: Maarten G J Snoeijs; Annemarie van Bijnen; Els Swennen; Guido R M M Haenen; L Jackson Roberts; Maarten H L Christiaans; Arnoud G Peppelenbosch; Wim A Buurman; L W Ernest van Heurn
Tubular epithelial injury and inflammation after ischemia and reperfusion in human kidney transplantation.
Annals of surgery 2011;253(3):598-604.
2011: Mohamed Moalin; Gino P F van Strijdonck; Geja Hagemen; Aalt Bast; Maud Beckers; Paul Borm; Guido R M M Haenen
A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives.
Molecules (Basel, Switzerland) 2011;16(11):9636-50.
2011: Nuria Mateo Anson; Anna-Marja Aura; Emilia Selinheimo; Ismo Mattila; Kaisa Poutanen; Robin van den Berg; Robert Havenaar; Aalt Bast; Guido R M M Haenen
Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts antiinflammatory effects ex vivo.
The Journal of nutrition 2011;141(1):137-43.
2010: Aalt Bast; Antje R Weseler; Guido R M M Haenen; Gertjan J M den Hartog
Oxidative stress and antioxidants in interstitial lung disease.
Current opinion in pulmonary medicine 2010;16(5):516-20.
2010: Gertjan J M den Hartog; Agnes W Boots; Aline Adam-Perrot; Fred Brouns; Inge W C M Verkooijen; Antje R Weseler; Guido R M M Haenen; Aalt Bast
Erythritol is a sweet antioxidant.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(4):449-58.
2010: Christiaan P Beljaars; Jiska M Balk; Aalt Bast; Guido R M M Haenen
Prevention of a systematic underestimation of antioxidant activity in competition assays. The impact of unspecific reactions of the reactive species.
Biochemical and biophysical research communications 2010;392(3):346-50.
2010: Hilde Jacobs; Mohamed Moalin; Aalt Bast; Wim J F van der Vijgh; Guido R M M Haenen
An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network.
PloS one 2010;5(11):e13880.
2009: Nuria Mateo Anson; Emilia Selinheimo; Rob Havenaar; Anna-Marja Aura; Ismo Mattila; Pekka Lehtinen; Aalt Bast; Kaisa Poutanen; Guido R M M Haenen
Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds.
Journal of agricultural and food chemistry 2009;57(14):6148-55.
2009: Jiska M Balk; Aalt Bast; Guido R M M Haenen
Evaluation of the accuracy of antioxidant competition assays: incorrect assumptions with major impact.
Free radical biology & medicine 2009;47(2):135-44.
2009: Agnes W Boots; Milena Hristova; David I Kasahara; Guido R M M Haenen; Aalt Bast; Albert van der Vliet
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.
The Journal of biological chemistry 2009;284(26):17858-67.
2009: Hilde Jacobs; Wim J F van der Vijgh; Ger H Koek; Guy J J Draaisma; Mohamed Moalin; Gino P F van Strijdonck; Aalt Bast; Guido R M M Haenen
Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER.
Free radical biology & medicine 2009;46(12):1567-73.
2009: Agnes W Boots; Marjolein Drent; Els L R Swennen; Harald J J Moonen; Aalt Bast; Guido R M M Haenen
Antioxidant status associated with inflammation in sarcoidosis: a potential role for antioxidants.
Respiratory medicine 2009;103(3):364-72.
2009: Rik de Jongh; Miriam Dambros; Guido R M M Haenen; Gertjan J M den Hartog; Aalt Bast; Philip van Kerrebroeck; Gommert A van Koeveringe
Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder.
Neurourology and urodynamics 2009;28(5):461-7.
2008: Nuria Mateo Anson; Robin van den Berg; Rob Havenaar; Aalt Bast; Guido R M M Haenen
Ferulic acid from aleurone determines the antioxidant potency of wheat grain (Triticum aestivum L.).
Journal of agricultural and food chemistry 2008;56(14):5589-94.
2008: Agnes W Boots; Lonneke C Wilms; Els L R Swennen; Jos C S Kleinjans; Aalt Bast; Guido R M M Haenen
In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers.
Nutrition (Burbank, Los Angeles County, Calif.) 2008;24(7-8):703-10.
2008: Agnes W Boots; Guido R M M Haenen; Aalt Bast
Health effects of quercetin: from antioxidant to nutraceutical.
European journal of pharmacology 2008;585(2-3):325-37.
2008: Rik de Jongh; Guido R M M Haenen; Gommert A van Koeveringe; Miriam Dambros; Philip van Kerrebroeck
Lipid peroxidation product 4-hydroxynonenal contributes to bladder smooth muscle damage.
Urology 2008;71(5):974-8.
2008: Petal A H M Wijnen; Marjolein Drent; Patty J Nelemans; Petra M J C Kuijpers; Ger H Koek; Cees Neef; Guido R M M Haenen; Otto Bekers
Role of cytochrome P450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands.
Drug safety : an international journal of medical toxicology and drug experience 2008;31(12):1125-34.
2007: Saskia J Rietjens; Milou Beelen; René Koopman; Luc van Loon; Aalt Bast; Guido R M M Haenen
A single session of resistance exercise induces oxidative damage in untrained men.
Medicine and science in sports and exercise 2007;39(12):2145-51.
2007: Saskia J Rietjens; Aalt Bast; Guido R M M Haenen
New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol.
Journal of agricultural and food chemistry 2007;55(18):7609-14.
2007: Mariken J T J Arts; Christoph Grun; Ruud L de Jong; Hans-Peter Voss; Aalt Bast; Martin J Mueller; Guido R M M Haenen
Oxidative degradation of lipids during mashing.
Journal of agricultural and food chemistry 2007;55(17):7010-4.
2007: Lonneke C Wilms; Agnes W Boots; Vincent C J de Boer; Lou M Maas; Daniëlle M F A Pachen; Ralph W H Gottschalk; Hans B Ketelslegers; Roger Godschalk; Guido R M M Haenen; Frederik J Van Schooten; Jos C S Kleinjans
Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers.
Carcinogenesis 2007;28(8):1800-6.
2007: Agnes W Boots; Hui Li; Roel P F Schins; Rodger Duffin; Johan W M Heemskerk; Aalt Bast; Guido R M M Haenen
The quercetin paradox.
Toxicology and applied pharmacology 2007;222(1):89-96.
2007: Saskia J Rietjens; Aalt Bast; J de Vente; Guido R M M Haenen
The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NObullet response of isolated rat aorta.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1931-6.
2007: Michael D Coleman; Georgina S E Rimmer; Guido R M M Haenen
Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro.
Basic & clinical pharmacology & toxicology 2007;100(2):139-44.
2007: Aalt Bast; Guido R M M Haenen; Anna M E Bruynzeel; Wim J F van der Vijgh
Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials.
Cardiovascular toxicology 2007;7(2):154-9.
2007: Bashir M Rezk; Wim J F van der Vijgh; Aalt Bast; Guido R M M Haenen
Alpha-tocopheryl phosphate is a novel apoptotic agent.
Frontiers in bioscience : a journal and virtual library 2007;12():2013-9.
2007: Aalt Bast; Helena Kaiserová; Gertjan J M den Hartog; Guido R M M Haenen; Wim J F van der Vijgh
Protectors against doxorubicin-induced cardiotoxicity: flavonoids.
Cell biology and toxicology 2007;23(1):39-47.
2007: Rik de Jongh; Guido R M M Haenen; Gommert A van Koeveringe; Miriam Dambros; Jo De Mey; Philip van Kerrebroeck
Oxidative stress reduces the muscarinic receptor function in the urinary bladder.
Neurourology and urodynamics 2007;26(2):302-8.
2006: Nachum Vaisman; Guido R M M Haenen; Yahalomit Zaruk; Carin Verduyn; Jacques G Bindels; Sjors Verlaan; Erwin P Meijer
Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients.
Clinical nutrition (Edinburgh, Scotland) 2006;25(6):897-905.
2006: Michael D Coleman; Charlotte Williams; Guido R M M Haenen
Effects of lipoic acid and dihydrolipoic acid on 4-aminophenol-mediated erythrocytic toxicity in vitro.
Basic & clinical pharmacology & toxicology 2006;99(3):225-9.
2006: Freddy J Troost; Robert-Jan M Brummer; Guido R M M Haenen; Aalt Bast; Rachel I M van Haaften; Chris T A Evelo; Wim H M Saris
Gene expression in human small intestinal mucosa in vivo is mediated by iron-induced oxidative stress.
Physiological genomics 2006;25(2):242-9.
2006: Guido R M M Haenen; Mariken J T J Arts; Aalt Bast; Michael D Coleman
Structure and activity in assessing antioxidant activity in vitro and in vivo A critical appraisal illustrated with the flavonoids.
Environmental toxicology and pharmacology 2006;21(2):191-8.
2005: Agnes W Boots; Jiska M Balk; Aalt Bast; Guido R M M Haenen
The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity.
Biochemical and biophysical research communications 2005;338(2):923-9.
2005: Agnes W Boots; Aalt Bast; Guido R M M Haenen
No role of DT-diaphorase (NQO1) in the protection against oxidized quercetin.
FEBS letters 2005;579(3):677-82.
2005: Marc A J G Fischer; Theo J M Gransier; Lenie M G Beckers; Otto Bekers; Aalt Bast; Guido R M M Haenen
Determination of the antioxidant capacity in blood.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(7):735-40.
2005: Harry R Gosker; Aalt Bast; Guido R M M Haenen; Marc A J G Fischer; Ger J van der Vusse; Emiel F M Wouters; Annemie M W J Schols
Altered antioxidant status in peripheral skeletal muscle of patients with COPD.
Respiratory medicine 2005;99(1):118-25.
2004: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
The extraordinary antioxidant activity of vitamin E phosphate.
Biochimica et biophysica acta 2004;1683(1-3):16-21.
2004: Gudrun Michels; Guido R M M Haenen; Wim Wätjen; Saskia J Rietjens; Aalt Bast
The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids.
Toxicology letters 2004;151(1):105-11.
2004: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.
The Journal of biological chemistry 2004;279(11):9693-7.
2004: Gertjan J M den Hartog; Guido R M M Haenen; Epie Boven; Wim J F van der Vijgh; Aalt Bast
Lecithinized copper,zinc-superoxide dismutase as a protector against doxorubicin-induced cardiotoxicity in mice.
Toxicology and applied pharmacology 2004;194(2):180-8.
2004: Mariken J T J Arts; Guido R M M Haenen; Hans-Peter Voss; Aalt Bast
Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(1):45-9.
2003: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore.
FEBS letters 2003;555(3):601-5.
2003: Agnes W Boots; Guido R M M Haenen; Aalt Bast
Oxidant metabolism in chronic obstructive pulmonary disease.
The European respiratory journal. Supplement 2003;46():14s-27s.
2003: Mohamed A I Abou El Hassan; Marc A Kedde; Ursula T H Zwiers; E Tourn; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
Bioavailability and pharmacokinetics of the cardioprotecting flavonoid 7-monohydroxyethylrutoside in mice.
Cancer chemotherapy and pharmacology 2003;52(5):371-6.
2003: Agnes W Boots; Nard Kubben; Guido R M M Haenen; Aalt Bast
Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation.
Biochemical and biophysical research communications 2003;308(3):560-5.
2003: Freddy J Troost; Wim H M Saris; Guido R M M Haenen; Aalt Bast; Robert-Jan M Brummer
New method to study oxidative damage and antioxidants in the human small bowel: effects of iron application.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(2):G354-9.
2003: Geja J Hageman; Ingrid Larik; Herman-Jan Pennings; Guido R M M Haenen; Emiel F M Wouters; Aalt Bast
Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients.
Free radical biology & medicine 2003;35(2):140-8.
2003: Rachel I M van Haaften; Guido R M M Haenen; Peter J van Bladeren; Jan J P Bogaards; Chris T A Evelo; Aalt Bast
Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(3):245-51.
2003: Rachel I M van Haaften; Guido R M M Haenen; Chris T A Evelo; Aalt Bast
Effect of vitamin E on glutathione-dependent enzymes.
Drug metabolism reviews 2003;35(2-3):215-53.
2003: Gertjan J M den Hartog; Agnes W Boots; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Lack of inhibition of endothelial nitric oxide synthase in the isolated rat aorta by doxorubicin.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(2):165-7.
2003: Gertjan J M den Hartog; Guido R M M Haenen; Erik Vegt; Wim J F van der Vijgh; Aalt Bast
Superoxide dismutase: the balance between prevention and induction of oxidative damage.
Chemico-biological interactions 2003;145(1):33-9.
2003: Theo M C M De Kok; I Zwingman; Edwin J C Moonen; P A E L Schilderman; EH Rhijnsburger; Guido R M M Haenen; Jos C S Kleinjans
Analysis of oxidative DNA damage after human dietary supplementation with linoleic acid.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(3):351-8.
2003: Aalt Bast; Guido R M M Haenen
Lipoic acid: a multifunctional antioxidant.
BioFactors (Oxford, England) 2003;17(1-4):207-13.
2002: Agnes W Boots; Guido R M M Haenen; Gertjan J M den Hartog; Aalt Bast
Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.
Biochimica et biophysica acta 2002;1583(3):279-84.
2002: Rachel I M van Haaften; Guido R M M Haenen; Chris T A Evelo; Aalt Bast
Tocotrienols inhibit human glutathione S-transferase P1-1.
IUBMB life 2002;54(2):81-4.
2002: Bashir M Rezk; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.
Biochemical and biophysical research communications 2002;295(1):9-13.
2002: Aalt Bast; Guido R M M Haenen
The toxicity of antioxidants and their metabolites.
Environmental toxicology and pharmacology 2002;11(3-4):251-8.
2002: Jan W Dallinga; Guido R M M Haenen; Aalt Bast; Frederik J Van Schooten
The effect of the trolox equivalent antioxidant capacity (TEAC) in plasma on the formation of 4-aminobiphenylhaemoglobin adducts in smokers.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2002;7(4):291-8.
2002: Ad M Knaapen; Catrin Albrecht; Andrea Becker; Doris Höhr; Astrid Winzer; Guido R M M Haenen; Paul J A Borm; Roel P F Schins
DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation.
Carcinogenesis 2002;23(7):1111-20.
2002: Gertjan J M den Hartog; Erik Vegt; Wim J F van der Vijgh; Guido R M M Haenen; Aalt Bast
Hypochlorous acid is a potent inhibitor of acetylcholinesterase.
Toxicology and applied pharmacology 2002;181(3):228-32.
2002: Chantal G M Heijnen; Guido R M M Haenen; R Minou Oostveen; Eva M Stalpers; Aalt Bast
Protection of flavonoids against lipid peroxidation: the structure activity relationship revisited.
Free radical research 2002;36(5):575-81.
2002: Guido R M M Haenen; A Bast
The use of vitamin supplements in self-medication.
Thérapie 2002;57(2):119-22.
2002: Gertjan J M den Hartog; Guido R M M Haenen; Erik Vegt; Wim J F van der Vijgh; Aalt Bast
Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?
Biological chemistry 2002;383(3-4):709-13.
2002: Mariken J T J Arts; Guido R M M Haenen; Lonneke C Wilms; Sasja A J N Beetstra; Chantal G M Heijnen; Hans-Peter Voss; Aalt Bast
Interactions between flavonoids and proteins: effect on the total antioxidant capacity.
Journal of agricultural and food chemistry 2002;50(5):1184-7.
2002: Frederik J Van Schooten; Ahmad Besaratinia; Ahmad Besarati Nia; Silvio De Flora; Francesco D'Agostini; Alberto Izzotti; Anna Camoirano; Alfons J M Balm; Jan W Dallinga; Aalt Bast; Guido R M M Haenen; Laura Van't Veer; Paul Baas; Harumasa Sakai; nico van zandwijk
Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(2):167-75.
2001: Rachel I M van Haaften; Gertjan J M den Hartog; Chris T A Evelo; Guido R M M Haenen; Aalt Bast
Hypochlorous acid is a potent inhibitor of GST P1-1.
Chemico-biological interactions 2001;138(1):77-83.
2001: C G Heijnen; J A Vekemans; Guido R M M Haenen; Aalt Bast
Peroxynitrite scavenging of flavonoids: structure activity relationship.
Environmental toxicology and pharmacology 2001;10(4):199-206.
2001: Mariken J T J Arts; Guido R M M Haenen; Hans-Peter Voss; Aalt Bast
Masking of antioxidant capacity by the interaction of flavonoids with protein.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(8):787-91.
2001: Rachel I M van Haaften; Chris T A Evelo; John Penders; M P Eijnwachter; Guido R M M Haenen; Aalt Bast
Inhibition of human glutathione S-transferase P1-1 by tocopherols and alpha-tocopherol derivatives.
Biochimica et biophysica acta 2001;1548(1):23-8.
2001: FA van Acker; Janneke W Hulshof; Guido R M M Haenen; Wiro M P B Menge; Wim J F van der Vijgh; Aalt Bast
New synthetic flavonoids as potent protectors against doxorubicin-induced cardiotoxicity.
Free radical biology & medicine 2001;31(1):31-7.
2001: JP Rhemrev; Jan P W Vermeiden; Guido R M M Haenen; J J De Bruijne; Lyset T M Rekers-Mombarg; Aalt Bast
Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.
Andrologia 2001;33(3):151-8.
2001: FA van Acker; Epie Boven; Klaas Kramer; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
Frederine, a new and promising protector against doxorubicin-induced cardiotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1378-84.
2001: Rachel I M van Haaften; Chris T A Evelo; Guido R M M Haenen; Aalt Bast
No reduction of alpha-tocopherol quinone by glutathione in rat liver microsomes.
Biochemical pharmacology 2001;61(6):715-9.
2001: Ahmad Besaratinia; A Besarati Nia; Frederik J Van Schooten; P A E L Schilderman; Theo M C M De Kok; Guido R M M Haenen; Marcel H M van Herwijnen; Ebienus van Agen; Daniëlle M F A Pachen; Jos C S Kleinjans
A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms.
Carcinogenesis 2001;22(3):395-401.
2001: C G Heijnen; Guido R M M Haenen; FA van Acker; Wim J F van der Vijgh; Aalt Bast
Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(1):3-6.
2001: Rachel I M van Haaften; Chris T A Evelo; Guido R M M Haenen; Aalt Bast
alpha-Tocopherol inhibits human glutathione S-transferase pi.
Biochemical and biophysical research communications 2001;280(3):631-3.
2000: FA van Acker; Saskia van Acker; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
In vitro screening of antitumour agents for cardiotoxicity by means of isolated mouse left atria.
Anticancer research 2000;20(6B):4483-7.
2000: JP Rhemrev; FW van Overveld; Guido R M M Haenen; T Teerlink; Aalt Bast; Jan P W Vermeiden
Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contributions of various seminal compounds.
Journal of andrology 2000;21(6):913-20.
2000: JB Paquay; Guido R M M Haenen; G Stender; Sheila A Wiseman; Lilian B M Tijburg; Aalt Bast
Protection against nitric oxide toxicity by tea.
Journal of agricultural and food chemistry 2000;48(11):5768-72.
2000: FA van Acker; J A Hageman; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast; Wiro M P B Menge
Synthesis of novel 3,7-substituted-2-(3',4'-dihydroxyphenyl)flavones with improved antioxidant activity.
Journal of medicinal chemistry 2000;43(20):3752-60.
2000: L A van Vliet; Nienke Rodenhuis; Håkan V Wikström; Thomas A Pugsley; Kevin A Serpa; Leonard T Meltzer; Thomas G Heffner; Lawrence D Wise; ME Lajiness; Rita M Huff; Kjell A Svensson; Guido R M M Haenen; Aalt Bast
Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.
Journal of medicinal chemistry 2000;43(19):3549-57.
2000: FW van Overveld; Guido R M M Haenen; JP Rhemrev; Jan P W Vermeiden; Aalt Bast
Tyrosine as important contributor to the antioxidant capacity of seminal plasma.
Chemico-biological interactions 2000;127(2):151-61.
2000: FA van Acker; O Schouten; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Flavonoids can replace alpha-tocopherol as an antioxidant.
FEBS letters 2000;473(2):145-8.
2000: FA van Acker; Saskia van Acker; Klaas Kramer; Guido R M M Haenen; Aalt Bast; Wim J F van der Vijgh
7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1337-41.
1998: GP Biewenga; D H Veening-Griffioen; A J Nicastia; Guido R M M Haenen; Aalt Bast
Effects of dihydrolipoic acid on peptide methionine sulfoxide reductase. Implications for antioxidant drugs.
Arzneimittel-Forschung 1998;48(2):144-8.
1997: M F Vriesman; Guido R M M Haenen; GJ Westerveld; JB Paquay; HP Voss; Aalt Bast
A method for measuring nitric oxide radical scavenging activity. Scavenging properties of sulfur-containing compounds.
Pharmacy world & science : PWS 1997;19(6):283-6.
1997: GP Biewenga; Guido R M M Haenen; Aalt Bast
The role of lipoic acid in the treatment of diabetic polyneuropathy.
Drug metabolism reviews 1997;29(4):1025-54.
1997: GP Biewenga; Guido R M M Haenen; Aalt Bast
The pharmacology of the antioxidant lipoic acid.
General pharmacology 1997;29(3):315-31.
1997: Guido R M M Haenen; JB Paquay; R E Korthouwer; Aalt Bast
Peroxynitrite scavenging by flavonoids.
Biochemical and biophysical research communications 1997;236(3):591-3.
1996: Aalt Bast; R M van der Plas; H van den Berg; Guido R M M Haenen
Beta-carotene as antioxidant.
European journal of clinical nutrition 1996;50 Suppl 3():S54-6.
1996: G P Biewenga; M A Dorstijn; J V Verhagen; Guido R M M Haenen; Aalt Bast
Reduction of lipoic acid by lipoamide dehydrogenase.
Biochemical pharmacology 1996;51(3):233-8.
1995: Saskia van Acker; M N Tromp; Guido R M M Haenen; Wim J F van der Vijgh; Aalt Bast
Flavonoids as scavengers of nitric oxide radical.
Biochemical and biophysical research communications 1995;214(3):755-9.
1993: T L Ching; Guido R M M Haenen; Aalt Bast
Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers.
Chemico-biological interactions 1993;86(2):119-27.
1991: Guido R M M Haenen; Aalt Bast
Scavenging of hypochlorous acid by lipoic acid.
Biochemical pharmacology 1991;42(11):2244-6.
1991: Aalt Bast; Guido R M M Haenen; C J Doelman
Oxidants and antioxidants: state of the art.
The American journal of medicine 1991;91(3C):2S-13S.
1991: Guido R M M Haenen; Frank Jansen; Nico P E Vermeulen; Aalt Bast
Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa.
Archives of biochemistry and biophysics 1991;287(1):48-52.
1990: Guido R M M Haenen; B M De Rooij; Nico P E Vermeulen; Aalt Bast
Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.
Molecular pharmacology 1990;37(3):412-22.
1990: Aalt Bast; Guido R M M Haenen
Regulation of lipid peroxidation by glutathione and lipoic acid: involvement of liver microsomal vitamin E free radical reductase.
Advances in experimental medicine and biology 1990;264():111-6.
1990: Guido R M M Haenen; M Veerman; Aalt Bast
Reduction of beta-adrenoceptor function by oxidative stress in the heart.
Free radical biology & medicine 1990;9(4):279-88.
1989: Guido R M M Haenen; B M de Rooij; H Timmerman; Aalt Bast
Beta-adrenoceptor agonists do not reduce hydrogen peroxide production from superoxide radicals.
Archives internationales de pharmacodynamie et de thérapie 1989;300():68-75.
1989: Guido R M M Haenen; Nico P E Vermeulen; H Timmerman; Aalt Bast
Effect of thiols on lipid peroxidation in rat liver microsomes.
Chemico-biological interactions 1989;71(2-3):201-12.
1989: Guido R M M Haenen; H J Plug; Nico P E Vermeulen; H Timmerman; Aalt Bast
Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of beta-adrenoceptor function in the heart by oxidative stress.
Life sciences 1989;45(1):71-6.
1988: Aalt Bast; Guido R M M Haenen
Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation.
Biochimica et biophysica acta 1988;963(3):558-61.
1988: A R Goeptar; Guido R M M Haenen; H Timmerman; Aalt Bast
The effects of beta-adrenergic receptor agonists on the H2O2 formation in alveolar macrophage suspensions are not mediated by beta-receptors.
Agents and actions 1988;25(3-4):375-7.
1988: Guido R M M Haenen; Nico P E Vermeulen; J N Tai Tin Tsoi; H M Ragetli; H Timmerman; A Blast
Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein.
Biochemical pharmacology 1988;37(10):1933-8.
1988: Guido R M M Haenen; P Van Dansik; Nico P E Vermeulen; H Timmerman; Aalt Bast
The effect of hydrogen peroxide on beta-adrenoceptor function in the heart.
Free radical research communications 1988;4(4):243-9.
1987: Guido R M M Haenen; J N Tai Tin Tsoi; Nico P E Vermeulen; H Timmerman; Aalt Bast
4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection.
Archives of biochemistry and biophysics 1987;259(2):449-56.