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David Hafler

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Multiple Sclerosis

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Markus Kleinewietfeld; Heda Kvakan; Ralf A Linker; Arndt Manzel; Dominik N Muller; Jens Titze; Nir Yosef; David A Hafler
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Chris Cotsapas; David A Hafler
Immune-mediated disease genetics: the shared basis of pathogenesis.
Youjin Lee; Anneli Peters; Francisco J Quintana; Aviv Regev; Raymond A Sobel; Chuan Wu; Sheng Xiao; Nir Yosef; Amit Awasthi; David A Hafler; Markus Kleinewietfeld; Sharon Kunder; Vijay K Kuchroo
Induction and molecular signature of pathogenic TH17 cells.

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All Publications

2013: Markus Kleinewietfeld; Heda Kvakan; Ralf A Linker; Arndt Manzel; Dominik N Muller; Jens Titze; Nir Yosef; David A Hafler
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Nature 2013;496(7446):518-22.
2013: Chris Cotsapas; David A Hafler
Immune-mediated disease genetics: the shared basis of pathogenesis.
Trends in immunology 2013;34(1):22-6.
2012: Youjin Lee; Anneli Peters; Francisco J Quintana; Aviv Regev; Raymond A Sobel; Chuan Wu; Sheng Xiao; Nir Yosef; Amit Awasthi; David A Hafler; Markus Kleinewietfeld; Sharon Kunder; Vijay K Kuchroo
Induction and molecular signature of pathogenic TH17 cells.
Nature immunology 2012;13(10):991-9.
2012: Linda Ottoboni; Pablo Tamayo; Howard L Weiner; Guy J Buckle; David A Hafler; Brendan T Keenan; Samia J Khoury; Manik Kuchroo; Jill P Mesirov; Philip De Jager
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.
Science translational medicine 2012;4(153):153ra131.
2012: Daniel E Lowther; David A Hafler
Regulatory T cells in the central nervous system.
Immunological reviews 2012;248(1):156-69.
2012: Karoline Kickler; Kathryn Maltby; Siobhán Ni Choileain; Jillian Stephen; Sheila Wright; David A Hafler; Henry N Jabbour; Anne L Astier
Prostaglandin E2 affects T cell responses through modulation of CD46 expression.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5303-10.
2012: Ester Lozano; Vijay Kuchroo; Margarita Dominguez-Villar; David A Hafler
The TIGIT/CD226 axis regulates human T cell function.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3869-75.
2012: David A Hafler
Perspective: Deconstructing a disease.
Nature 2012;484(7393):S6.
2012: Alyssa Nylander; David A Hafler
Multiple sclerosis.
The Journal of clinical investigation 2012;122(4):1180-8.
2012: Qing Han; Douglas A Lauffenburger; Neda Bagheri; Elizabeth M Bradshaw; David A Hafler; J Christopher Love
Polyfunctional responses by human T cells result from sequential release of cytokines.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1607-12.
2012: Daniel Pelletier; David A Hafler
Fingolimod for multiple sclerosis.
The New England journal of medicine 2012;366(4):339-47.
2012: Cristina Maria Costantino; Hidde L Ploegh; Eric Spooner; David A Hafler
Class II MHC self-antigen presentation in human B and T lymphocytes.
PloS one 2012;7(1):e29805.
2011: David M Kofler; Narine Mousissian; Christopher A Severson; Philip L De Jager; David A Hafler
The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3286-91.
2011: Rebecca L Zuvich; Lisa F Barcellos; Ashley H Beecham; William S Bush; Alastair Compston; Philip L De Jager; David A Hafler; Stephen L Hauser; Adrian J Ivinson; Jacob McCauley; Douglas P Mortlock; Margaret Pericak-Vance; Stephen Sawcer; Jonathan L Haines
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.
Human molecular genetics 2011;20(17):3517-24.
2011: Chris Cotsapas; Mark J Daly; Philip L De Jager; James T Elder; Robert R Graham; Peter Gregersen; David A Hafler; Lars Klareskog; Kasper Lage; Benjamin M Neale; Stephen S Rich; Elizabeth Rossin; Katherine A Siminovitch; John A Todd; David A van Heel; Benjamin F Voight; chris wallace; Cisca Wijmenga; Jane Worthington; Gonçalo R Abecasis; Jeffrey C Barrett; Timothy Behrens; Judy Cho
Pervasive sharing of genetic effects in autoimmune disease.
PLoS genetics 2011;7(8):e1002254.
2011: Khadir Raddassi; Vicki Seyfert-Margolis; Junbao Yang; Kasia Bourcier; Elizabeth M Bradshaw; Sally C Kent; William W Kwok; Gerald T Nepom; David A Hafler
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):1039-46.
2011: Margarita Dominguez-Villar; Clare M Baecher-Allan; David A Hafler
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.
Nature medicine 2011;17(6):673-5.
2011: Margarita Dominguez-Villar; David A Hafler
Immunology. An innate role for IL-17.
Science (New York, N.Y.) 2011;332(6025):47-8.
2011: Birgit Obermeier; Laura Lovato; Reinhard Mentele; Wolfgang Brück; Ignasi Forné; Axel Imhof; Friedrich Lottspeich; Katherine W Turk; Simon N Willis; Hartmut Wekerle; Reinhard Hohlfeld; David A Hafler; Kevin C O'Connor; Klaus Dornmair
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.
Journal of neuroimmunology 2011;233(1-2):245-8.
2011: Robert Gross; Brian C Healy; Sabine Cepok; Tanuja Chitnis; Samia J Khoury; Bernard Hemmer; Howard L Weiner; David A Hafler; Philip De Jager
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.
Journal of neuroimmunology 2011;233(1-2):168-74.
2011: Clare M Baecher-Allan; Cristina M Costantino; Gregory L Cvetanovich; Charles W Ashley; Gaëlle Beriou; Margarita Dominguez-Villar; David A Hafler
CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(6):3317-26.
2011: Laura Lovato; Simon N Willis; Scott J Rodig; Tyler Caron; Stefany E Almendinger; Owain W Howell; Richard Reynolds; Kevin C O'Connor; David A Hafler
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.
Brain : a journal of neurology 2011;134(Pt 2):534-41.
2011: Tania Konry; Margarita Dominguez-Villar; Clare Baecher-Allan; David A Hafler; Martin L Yarmush
Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.
Biosensors & bioelectronics 2011;26(5):2707-10.
2011: Amanda A Fox; David A Hafler; Daniel S Herman; Kuang-Yu Liu; Jochen Muehlschlegel; Tjorvi E Perry; Mias Pretorius; Dan M Roden; Simon Body; Charles Collard; Dawood Darbar; Philip De Jager; Steven R Depalma; Brian S Donahue; Jonathan G Seidman; Stanton K Shernan; Christine E Seidman
Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery.
PloS one 2011;6(9):e24593.
2011: Joanne H Wang; Derek Pappas; Daniel Pelletier; Chris H Polman; Sergio E Baranzini; Lori B Chibnik; Paul Iw de Bakker; Philip De Jager; David A Hafler; Stephen L Hauser; Ludwig Kappos; Paul M Matthews; Jorge R Oksenberg
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.
Genome medicine 2011;3(1):3.
2010: Gregory L Cvetanovich; David A Hafler
Human regulatory T cells in autoimmune diseases.
Current opinion in immunology 2010;22(6):753-60.
2010: Farren B S Briggs; Selena Bartlett; Benjamin A Goldstein; Joanne Wang; Jacob McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen L Hauser; Jorge R Oksenberg; Stephen Sawcer; Margaret Pericak-Vance; Jonathan L Haines; Lisa F Barcellos
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.
Human molecular genetics 2010;19(21):4286-95.
2010: Samia J Khoury; Brian C Healy; Pia Kivisäkk; Vissia Viglietta; Svetlana Egorova; Charles R G Guttmann; Josiah F Wedgwood; David A Hafler; Howard L Weiner; Guy Buckle; Sandra Cook; Susheel Reddy
A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.
Archives of neurology 2010;67(9):1055-61.
2010: B C Healy; Maria Liguori; D Tran; Tanuja Chitnis; B Glanz; C Wolfish; S Gauthier; Guy J Buckle; M Houtchens; L Stazzone; S Khoury; R Hartzmann; M Fernandez-Vina; David A Hafler; Howard L Weiner; Charles R G Guttmann; Philip De Jager
HLA B*44: protective effects in MS susceptibility and MRI outcome measures.
Neurology 2010;75(7):634-40.
2010: Farren B S Briggs; Benjamin A Goldstein; Jacob McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen L Hauser; Jorge R Oksenberg; Stephen Sawcer; Margaret Pericak-Vance; Jonathan L Haines; Lisa F Barcellos
Variation within DNA repair pathway genes and risk of multiple sclerosis.
American journal of epidemiology 2010;172(2):217-24.
2010: Shimon Sakaguchi; Makoto Miyara; Cristina M Costantino; David A Hafler
FOXP3+ regulatory T cells in the human immune system.
Nature reviews. Immunology 2010;10(7):490-500.
2010: Gaëlle Beriou; Elizabeth M Bradshaw; Ester Lozano; Cristina M Costantino; William D Hastings; Tihamer Orban; Wassim Elyaman; Samia J Khoury; Vijay K Kuchroo; Clare Baecher-Allan; David A Hafler
TGF-beta induces IL-9 production from human Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):46-54.
2010: Qing Han; Elizabeth M Bradshaw; Björn Nilsson; David A Hafler; J Christopher Love
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving.
Lab on a chip 2010;10(11):1391-400.
2010: Paola G Bronson; Stacy J Caillier; Patricia P Ramsay; Jacob McCauley; Rebecca L Zuvich; Philip L De Jager; John D Rioux; Adrian J Ivinson; Alastair Compston; David A Hafler; Stephen Sawcer; Margaret Pericak-Vance; Jonathan L Haines; Stephen L Hauser; Jorge R Oksenberg; Lisa F Barcellos
CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
Human molecular genetics 2010;19(11):2331-40.
2010: Rebecca L Zuvich; Jacob McCauley; Jorge R Oksenberg; Stephen Sawcer; Philip L De Jager; Cristin Aubin; Anne H Cross; Laura Piccio; Neelum T Aggarwal; Denis Evans; David A Hafler; Alastair Compston; Stephen L Hauser; Margaret Pericak-Vance; Jonathan L Haines
Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.
Human genetics 2010;127(5):525-35.
2010: Eveliina Jakkula; Virpi Leppä; Anna-Maija Sulonen; Teppo Varilo; Suvi Kallio; Anu Kemppinen; Shaun Purcell; Keijo Koivisto; Pentti J Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Arpo Aromaa; Annette Bang Oturai; Helle Bach Søndergaard; Hanne F Harbo; Inger-Lise Mero; Stacey B Gabriel; Daniel B Mirel; Stephen L Hauser; Ludwig Kappos; Chris Polman; Philip L De Jager; David A Hafler; Mark J Daly; Aarno Palotie; Janna Saarela; Leena Peltonen
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
American journal of human genetics 2010;86(2):285-91.
2010: Anne L Astier; Gaëlle Beriou; Thomas M Eisenhaure; Stephen M Anderton; David A Hafler; Nir Hacohen
RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):685-93.
2010: Qing Song; Qing Han; Elizabeth M Bradshaw; Sally C Kent; Khadir Raddassi; Björn Nilsson; Gerald Nepom; David A Hafler; J Christopher Love
On-chip activation and subsequent detection of individual antigen-specific T cells.
Analytical chemistry 2010;82(2):473-7.
2010: Alok K Sharma; Yan Ling; Allison B Greer; David A Hafler; Sally C Kent; Yong Zhang; Alan C Rigby
Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry.
The journal of physical chemistry. B 2010;114(1):585-91.
2010: Bruce A C Cree; John D Rioux; Jacob McCauley; Pierre-Antoine Gourraud; Philippe Goyette; Joseph McElroy; Philip De Jager; Adam Santaniello; Timothy J Vyse; Peter K Gregersen; Daniel Mirel; David A Hafler; Jonathan L Haines; Margaret Pericak-Vance; Alastair Compston; Stephen Sawcer; Jorge R Oksenberg; Stephen L Hauser
A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
PloS one 2010;5(6):e11296.
2010: Christopher Severson; David A Hafler
T-cells in multiple sclerosis.
Results and problems in cell differentiation 2010;51():75-98.
2009: Philip De Jager; Lori B Chibnik; Jing Cui; Joachim Reischl; Stephan Lehr; K Claire Simon; Cristin Aubin; David Bauer; Jürgen F Heubach; Rupert Sandbrink; Michaela Tyblova; Petra Lelkova; Eva Havrdova; Christoph Pohl; Dana Horakova; Alberto Ascherio; David A Hafler; Elizabeth W Karlson
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.
Lancet neurology 2009;8(12):1111-9.
2009: Simon N Willis; Christine Stadelmann; Scott J Rodig; Tyler Caron; Stefan Gattenloehner; Scott S Mallozzi; Jill E Roughan; Stefany E Almendinger; Megan M Blewett; Wolfgang Brück; David A Hafler; Kevin C O'Connor
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.
Brain : a journal of neurology 2009;132(Pt 12):3318-28.
2009: John D Rioux; Philippe Goyette; Timothy J Vyse; Lennart Hammarström; Michelle M A Fernando; Todd Green; Philip L De Jager; Sylvain Foisy; Joanne Wang; Paul I W de Bakker; Stephen Leslie; Gilean McVean; Leonid Padyukov; Lars Alfredsson; Vito Annese; David A Hafler; Qiang Pan-Hammarstrom; Ritva Matell; Stephen J Sawcer; Alastair D Compston; Bruce A C Cree; Daniel B Mirel; Mark J Daly; timothy wayne behrens; Lars Klareskog; Peter K Gregersen; Jorge R Oksenberg; Stephen L Hauser
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18680-5.
2009: David V Liu; Lisa M Maier; David A Hafler; K Dane Wittrup
Engineered interleukin-2 antagonists for the inhibition of regulatory T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(9):887-94.
2009: Elizabeth M Bradshaw; Khadir Raddassi; Wassim Elyaman; Tihamer Orban; Peter A Gottlieb; Sally C Kent; David A Hafler
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4432-9.
2009: Katherine McLaughlin; Tanuja Chitnis; Jia Newcombe; Bettina Franz; Julia Kennedy; Shannon McArdel; Jens Kuhle; Ludwig Kappos; Kevin Rostasy; Daniela Pohl; Donald Gagne; Jayne M Ness; Silvia Tenembaum; Kevin C O'Connor; Vissia Viglietta; Susan J Wong; Norma P Tavakoli; Jerome de Seze; Zhannat Idrissova; Samia J Khoury; Amit Bar-Or; David A Hafler; Brenda Banwell; Kai W Wucherpfennig
Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):4067-76.
2009: William D Hastings; David E Anderson; Nasim Kassam; Ken Koguchi; Edward Greenfield; Sally C Kent; Xin Xiao Zheng; Terry B Strom; David A Hafler; Vijay K Kuchroo
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.
European journal of immunology 2009;39(9):2492-501.
2009: Steven C Greenway; Alexandre C Pereira; Jennifer C Lin; Steven R Depalma; Samuel J Israel; Sonia M Mesquita; Emel Ergul; Jessie H Conta; Joshua M Korn; Steven A McCarroll; Joshua M Gorham; Stacey Gabriel; David Altshuler; Maria de Lourdes Quintanilla-Dieck; Maria Alexandra Artunduaga; Roland D Eavey; Robert M Plenge; Nancy A Shadick; Michael E Weinblatt; Philip De Jager; David A Hafler; Roger E Breitbart; Jonathan G Seidman; Christine E Seidman
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
Nature genetics 2009;41(8):931-5.
2009: Cristina Maria Costantino; Hidde L Ploegh; David A Hafler
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):945-52.
2009: Gregory P Owens; Jeffrey Bennett; Hans Lassmann; Kevin C O'Connor; Alanna M Ritchie; Andrew Shearer; Chiwah Lam; Xiaoli Yu; Marius Birlea; Cecily DuPree; R Anthony Williamson; David A Hafler; Mark P Burgoon; Don Gilden
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.
Annals of neurology 2009;65(6):639-49.
2009: Saumyadipta Pyne; Xinli Hu; Kui Wang; Elizabeth Rossin; Tsung-I Lin; Lisa M Maier; Clare Baecher-Allan; Geoffrey J McLachlan; Pablo Tamayo; David A Hafler; Philip L De Jager; Jill P Mesirov
Automated high-dimensional flow cytometric data analysis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8519-24.
2009: Lisa M Maier; David A Hafler
Autoimmunity risk alleles in costimulation pathways.
Immunological reviews 2009;229(1):322-36.
2009: Suvi P Kallio; Eveliina Jakkula; Shaun Purcell; Minna Suvela; Keijo Koivisto; Pentti J Tienari; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Denis Bronnikov; Markku Viander; Seppo Meri; Jan Hillert; Frida Lundmark; Hanne F Harbo; Aslaug R Lorentzen; Philip L De Jager; Mark J Daly; David A Hafler; Aarno Palotie; Leena Peltonen; Janna Saarela
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
Human molecular genetics 2009;18(9):1670-83.
2009: Gaëlle Beriou; Cristina M Costantino; Charles W Ashley; Li Yang; Vijay K Kuchroo; Clare Baecher-Allan; David A Hafler
IL-17-producing human peripheral regulatory T cells retain suppressive function.
Blood 2009;113(18):4240-9.
2009: Lisa M Maier; David E Anderson; Christopher A Severson; Clare Baecher-Allan; Brian Healy; David V Liu; K Dane Wittrup; Philip De Jager; David A Hafler
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1541-7.
2009: Lisa M Maier; Christopher E Lowe; Jason Cooper; Kate Downes; David E Anderson; Christopher Severson; Pamela M Clark; Brian Healy; Neil Walker; Cristin Aubin; Jorge R Oksenberg; Stephen L Hauser; Alistair Compston; Stephen Sawcer; Philip De Jager; Linda S Wicker; John A Todd; David A Hafler
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
PLoS genetics 2009;5(1):e1000322.
2008: David A Hafler; Vijay K Kuchroo
TIMs: central regulators of immune responses.
The Journal of experimental medicine 2008;205(12):2699-701.
2008: Cristina Maria Costantino; Clare Baecher-Allan; David A Hafler
Multiple sclerosis and regulatory T cells.
Journal of clinical immunology 2008;28(6):697-706.
2008: Elizabeth M Bradshaw; Sally C Kent; Vinay Tripuraneni; Tihamer Orban; Hidde L Ploegh; David A Hafler; J Christopher Love
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.
Clinical immunology (Orlando, Fla.) 2008;129(1):10-8.
2008: Vissia Viglietta; K Bourcier; Guy J Buckle; B Healy; Howard L Weiner; David A Hafler; S Egorova; Charles R G Guttmann; J R Rusche; Samia J Khoury
CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.
Neurology 2008;71(12):917-24.
2008: Li Yang; David E Anderson; Clare Baecher-Allan; William D Hastings; Estelle Bettelli; Mohamed Oukka; Vijay K Kuchroo; David A Hafler
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.
Nature 2008;454(7202):350-2.
2008: Rex Smith; Sally C Kent; Julie Nagle; Martin Selig; A John Iafrate; Nader Najafian; David A Hafler; Hugh Auchincloss; Tihamer Orban; Enrico Cagliero
Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss.
Transplantation 2008;86(1):54-62.
2008: Philip De Jager; Elizabeth Rossin; Saumyadipta Pyne; Pablo Tamayo; Linda Ottoboni; Vissia Viglietta; Mira Weiner; Dulce Soler; Elena Izmailova; Lauren Faron-Yowe; Carmeline O'Brien; Sam Freeman; Susana Granados; Alex Parker; Ronenn Roubenoff; Jill P Mesirov; Samia J Khoury; David A Hafler; Howard L Weiner
Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells.
Brain : a journal of neurology 2008;131(Pt 7):1701-11.
2008: Cristina M Costantino; Clare M Baecher-Allan; David A Hafler
Human regulatory T cells and autoimmunity.
European journal of immunology 2008;38(4):921-4.
2008: Roselynn Rodriguez-Manzanet; Jennifer Hartt Meyers; Savithri Balasubramanian; Jacqueline Slavik; Nasim Kassam; Valerie Dardalhon; Edward Greenfield; Ana C Anderson; Raymond A Sobel; David A Hafler; Terry B Strom; Vijay K Kuchroo
TIM-4 expressed on APCs induces T cell expansion and survival.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4706-13.
2008: Li Yang; David E Anderson; Juhi Kuchroo; David A Hafler
Lack of TIM-3 immunoregulation in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4409-14.
2008: Philip De Jager; K C Simon; K L Munger; John D Rioux; David A Hafler; A Ascherio
Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.
Neurology 2008;70(13 Pt 2):1113-8.
2008: Adi Vaknin-Dembinsky; Gopal Murugaiyan; David A Hafler; Anne L Astier; Howard L Weiner
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.
Journal of neuroimmunology 2008;195(1-2):140-5.
2008: Cristina M Costantino; Howard C Hang; Sally C Kent; David A Hafler; Hidde L Ploegh
Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2876-85.
2008: Lisa M Maier; David A Hafler
The developing mosaic of autoimmune disease risk.
Nature genetics 2008;40(2):131-2.
2007: Lisa M Maier; David E Anderson; Philip De Jager; Linda S Wicker; David A Hafler
Allelic variant in CTLA4 alters T cell phosphorylation patterns.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18607-12.
2007: Ana C Anderson; David E Anderson; Lisa Bregoli; William D Hastings; Nasim Kassam; Charles Lei; Rucha Chandwaskar; Jozsef Karman; Ee W Su; Mitsuomi Hirashima; Jeffrey N Bruce; Lawrence P Kane; Vijay K Kuchroo; David A Hafler
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Science (New York, N.Y.) 2007;318(5853):1141-3.
2007: Anne L Astier; David A Hafler
Abnormal Tr1 differentiation in multiple sclerosis.
Journal of neuroimmunology 2007;191(1-2):70-8.
2007: David A Hafler; Alastair Compston; Stephen Sawcer; Eric S Lander; Mark J Daly; Philip De Jager; Paul I W de Bakker; Stacey B Gabriel; Daniel B Mirel; Adrian J Ivinson; Margaret Pericak-Vance; Simon G Gregory; John D Rioux; Jacob McCauley; Jonathan L Haines; Lisa F Barcellos; Bruce A C Cree; Jorge R Oksenberg; Stephen L Hauser
Risk alleles for multiple sclerosis identified by a genomewide study.
The New England journal of medicine 2007;357(9):851-62.
2007: Kai W Wucherpfennig; Paul M Allen; Franco Celada; Irun R Cohen; Rob De Boer; K Christopher Garcia; Byron Goldstein; Ralph Greenspan; David A Hafler; Philip Hodgkin; Erik S Huseby; David C Krakauer; David Nemazee; Alan S Perelson; Clemencia Pinilla; Roland K Strong; Eli E Sercarz
Polyspecificity of T cell and B cell receptor recognition.
Seminars in immunology 2007;19(4):216-24.
2007: Shalina S Ousman; Beren H Tomooka; Johannes M van Noort; Eric F Wawrousek; Kevin C O'Connor; David A Hafler; Raymond A Sobel; William H Robinson; Lawrence Steinman
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.
Nature 2007;448(7152):474-9.
2007: Philip De Jager; Denis Franchimont; Alicja Waliszewska; Alain Bitton; Albert Cohen; Diane Langelier; J Belaiche; Severine Vermeire; Lisa Farwell; An Goris; Cecile Libioulle; NIRAJ JANI; Themistocles Dassopoulos; Gillian P Bromfield; Bruno Dubois; J H Cho; Steven R Brant; Richard H Duerr; Haifeng Yang; J I Rotter; M S Silverberg; A Hillary Steinhart; Mark J Daly; Daniel K Podolsky; E Louis; David A Hafler; John D Rioux
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.
Genes and immunity 2007;8(5):387-97.
2007: Guifang Cai; David A Hafler
Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes.
European journal of immunology 2007;37(3):602-12.
2007: Tai Wai Yeo; Philip De Jager; Simon G Gregory; Lisa F Barcellos; Amie Walton; An Goris; Chiara Fenoglio; Maria Ban; Craig J Taylor; Reyna S Goodman; Emily Walsh; Cara S Wolfish; Roger HORTON; James A Traherne; Stephan Beck; John Trowsdale; Stacy J Caillier; Adrian J Ivinson; Todd Green; Susan Pobywajlo; Eric S Lander; Margaret Pericak-Vance; Jonathan L Haines; Mark J Daly; Jorge R Oksenberg; Stephen L Hauser; Alastair Compston; David A Hafler; John D Rioux; Stephen Sawcer
A second major histocompatibility complex susceptibility locus for multiple sclerosis.
Annals of neurology 2007;61(3):228-36.
2007: Kevin C O'Connor; Katherine McLaughlin; Philip De Jager; Tanuja Chitnis; Estelle Bettelli; Chenqi Xu; William H Robinson; Sunil V Cherry; Amit Bar-Or; Brenda L Banwell; Hikoaki Fukaura; Toshiyuki Fukazawa; Silvia Tenembaum; Susan J Wong; Norma P Tavakoli; Zhannat Idrissova; Vissia Viglietta; Kevin Rostasy; Daniela Pohl; Russell C Dale; Mark Freedman; Lawrence Steinman; Guy J Buckle; Vijay K Kuchroo; David A Hafler; Kai W Wucherpfennig
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.
Nature medicine 2007;13(2):211-7.
2007: Philip De Jager; David A Hafler
New therapeutic approaches for multiple sclerosis.
Annual review of medicine 2007;58():417-32.
2007: Elizabeth M Bradshaw; Ana Orihuela; Shannon L McArdel; Mohammad Salajegheh; Anthony A Amato; David A Hafler; Steven A Greenberg; Kevin C O'Connor
A local antigen-driven humoral response is present in the inflammatory myopathies.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):547-56.
2006: Anne L Astier; Gregory Meiffren; Samuel Freeman; David A Hafler
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.
The Journal of clinical investigation 2006;116(12):3252-7.
2006: Paul I W de Bakker; Gil McVean; Pardis C Sabeti; Marcos M Miretti; Todd Green; Jonathan Marchini; Xiayi Ke; Alienke J Monsuur; Pamela Whittaker; Marcos Delgado; Jonathan Morrison; Angela Richardson; Emily C Walsh; Xiaojiang Gao; Luana Galver; John Hart; David A Hafler; Margaret Pericak-Vance; John A Todd; Mark J Daly; John Trowsdale; Cisca Wijmenga; Timothy J Vyse; Stephan Beck; Sarah Shaw Murray; Mary Carrington; Simon Gregory; Panos Deloukas; John D Rioux
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.
Nature genetics 2006;38(10):1166-72.
2006: Arnon Karni; Michal Abraham; Alon Monsonego; Guifang Cai; Gordon J Freeman; David A Hafler; Samia J Khoury; Howard L Weiner
Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):4196-202.
2006: Clare Baecher-Allan; David A Hafler
Human regulatory T cells and their role in autoimmune disease.
Immunological reviews 2006;212():203-16.
2006: Ken Koguchi; David E Anderson; Li Yang; Kevin C O'Connor; Vijay K Kuchroo; David A Hafler
Dysregulated T cell expression of TIM3 in multiple sclerosis.
The Journal of experimental medicine 2006;203(6):1413-8.
2006: Philip De Jager; R Graham; Lisa Farwell; Stephen Sawcer; A Richardson; timothy wayne behrens; Alastair Compston; David A Hafler; Juha Kere; Timothy J Vyse; John D Rioux
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.
Genes and immunity 2006;7(4):327-34.
2006: Clare M Baecher-Allan; David A Hafler
The purification and functional analysis of human CD4+CD25high regulatory T cells.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2006;Chapter 7():Unit 7.4B.
2006: Clare Baecher-Allan; Elizabeth Wolf; David A Hafler
MHC class II expression identifies functionally distinct human regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4622-31.
2006: Philip De Jager; Stephen Sawcer; Alicja Waliszewska; Lisa Farwell; Gary Wild; Albert Cohen; Diane Langelier; Alain Bitton; Alastair Compston; David A Hafler; John D Rioux
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
European journal of human genetics : EJHG 2006;14(3):317-21.
2006: Kevin C O'Connor; Sushmita Mimi Roy; Christopher H Becker; David A Hafler; Aaron B Kantor
Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers.
Disease markers 2006;22(4):213-25.
2005: Clare M Baecher-Allan; David A Hafler
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells.
Clinical immunology (Orlando, Fla.) 2005;117(2):192; discussion 193.
2005: David Reich; Nick Patterson; Philip De Jager; Gavin J McDonald; Alicja Waliszewska; Arti Tandon; Robin R Lincoln; Cari DeLoa; Scott A Fruhan; Philippe Cabre; Odile Bera; Gilbert Semana; M Ann Kelly; David A Francis; Kristin G Ardlie; OA Khan; Bruce A C Cree; Stephen L Hauser; Jorge R Oksenberg; David A Hafler
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
Nature genetics 2005;37(10):1113-8.
2005: Sally C Kent; Yahua Chen; Sue M Clemmings; Vissia Viglietta; Norma S Kenyon; Camillo Ricordi; Bernhard J Hering; David A Hafler
Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4458-64.
2005: Kevin C O'Connor; Heiner Appel; Lisa Bregoli; Matthew E Call; Ingrid Catz; Jennifer A Chan; Nicole H Moore; Kenneth G Warren; Susan J Wong; David A Hafler; Kai W Wucherpfennig
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1974-82.
2005: Lara J Ausubel; Kevin C O'Connor; Clare Baecher-Allen; Christina Trollmo; Benedikt Kessler; Brian Hekking; David Merritt; Abbie L Meyer; Bill Kwok; Hidde L Ploegh; Brigitte T Huber; David A Hafler
Characterization of in vivo expanded OspA-specific human T-cell clones.
Clinical immunology (Orlando, Fla.) 2005;115(3):313-22.
2005: Sally C Kent; Yahua Chen; Lisa Bregoli; Sue M Clemmings; Norma S Kenyon; Camillo Ricordi; Bernhard J Hering; David A Hafler
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
Nature 2005;435(7039):224-8.
2005: Clare Baecher-Allan; Elizabeth Wolf; David A Hafler
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells.
Clinical immunology (Orlando, Fla.) 2005;115(1):10-8.
2005: David A Hafler; Jacqueline Slavik; David E Anderson; Kevin C O'Connor; Philip De Jager; Clare Baecher-Allan
Multiple sclerosis.
Immunological reviews 2005;204():208-31.
2005: Stephan Ellmerich; Marcin P Mycko; Katalin Takacs; Hanspeter Waldner; Faisal Wahid; Rosemary J Boyton; Rosalind H M King; Paul A Smith; Sandra Amor; Amy H Herlihy; Rachel E Hewitt; Mark Jutton; David A Price; David A Hafler; Vijay K Kuchroo; Daniel M Altmann
High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1938-46.
2005: David A Hafler; Philip De Jager
Applying a new generation of genetic maps to understand human inflammatory disease.
Nature reviews. Immunology 2005;5(1):83-91.
2004: Stephen Sawcer; Mel Maranian; Sara Singlehurst; Taiwai Yeo; Alastair Compston; Mark J Daly; Philip De Jager; Stacey Gabriel; David A Hafler; Adrian J Ivinson; Eric S Lander; John D Rioux; Emily Walsh; Simon G Gregory; Silke Schmidt; Margaret Pericak-Vance; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.
Human molecular genetics 2004;13(17):1943-9.
2004: Clare Baecher-Allan; David A Hafler
Suppressor T cells in human diseases.
The Journal of experimental medicine 2004;200(3):273-6.
2004: Guifang Cai; Arnon Karni; Enedina M L Oliveira; Howard L Weiner; David A Hafler; Gordon J Freeman
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.
Cellular immunology 2004;230(2):89-98.
2004: Philip De Jager; Emily C Walsh; John D Rioux; David A Hafler
Re: GAMES issue study: Are international genetic consortia functional?
Journal of neuroimmunology 2004;153(1-2):5-6.
2004: Marcin P Mycko; Hanspeter Waldner; David E Anderson; Katarzyna D Bourcier; Kai W Wucherpfennig; Vijay K Kuchroo; David A Hafler
Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1689-98.
2004: Stephan Ellmerich; Katalin Takacs; Marcin P Mycko; Hanspeter Waldner; Faisal Wahid; Rosemary J Boyton; Paul A Smith; Sandra Amor; David Baker; David A Hafler; Vijay K Kuchroo; Daniel M Altmann
Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis.
European journal of immunology 2004;34(7):1839-48.
2004: Mohsen Khademi; Zsolt Illés; Alexander W Gielen; Monica Marta; Naruhiko Takazawa; Claire Baecher-Allan; Lou Brundin; Jan Hannerz; Claes Martin; Robert A Harris; David A Hafler; Vijay K Kuchroo; Tomas Olsson; Fredrik Piehl; Erik Wallström
T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7169-76.
2004: Lalitha Vijayakrishnan; Jacqueline Slavik; Zsolt Illés; Rebecca J Greenwald; Dan Rainbow; Bernhard Greve; Laurence B Peterson; David A Hafler; Gordon J Freeman; Arlene H Sharpe; Linda S Wicker; Vijay K Kuchroo
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
Immunity 2004;20(5):563-75.
2004: Philip De Jager; David A Hafler
Gene expression profiling in MS: what is the clinical relevance?
Lancet neurology 2004;3(5):269.
2004: Nick Patterson; Neil Hattangadi; Barton Lane; Kirk E Lohmueller; David A Hafler; Jorge R Oksenberg; Stephen L Hauser; Michael W Smith; Stephen J O'Brien; David Altshuler; Mark J Daly; David Reich
Methods for high-density admixture mapping of disease genes.
American journal of human genetics 2004;74(5):979-1000.
2004: Vissia Viglietta; Clare Baecher-Allan; Howard L Weiner; David A Hafler
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.
The Journal of experimental medicine 2004;199(7):971-9.
2004: Clare Baecher-Allan; Vissia Viglietta; David A Hafler
Human CD4+CD25+ regulatory T cells.
Seminars in immunology 2004;16(2):89-98.
2004: David A Hafler
Multiple sclerosis.
The Journal of clinical investigation 2004;113(6):788-94.
2004: Jacqueline Slavik; Dong-Gyun Lim; Steven J Burakoff; David A Hafler
Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity.
The Journal of biological chemistry 2004;279(2):910-9.
2003: Emily C Walsh; Sheila Guschwan-McMahon; Mark J Daly; David A Hafler; John D Rioux
Genetic analysis of multiple sclerosis.
Journal of autoimmunity 2003;21(2):111-6.
2003: Dong-Gyun Lim; Jacqueline Slavik; Katarzyna Bourcier; Kathrine J Smith; David A Hafler
Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.
The Journal of experimental medicine 2003;198(1):99-109.
2003: MC Schmied; PW Duda; Jeffrey I Krieger; Christina Trollmo; David A Hafler
In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis.
Clinical immunology (Orlando, Fla.) 2003;106(3):163-74.
2003: Kevin C O'Connor; Tanuja Chitnis; Diane E Griffin; Sucheep Piyasirisilp; Amit Bar-Or; Samia Khoury; Kai W Wucherpfennig; David A Hafler
Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.
Journal of neuroimmunology 2003;136(1-2):140-8.
2003: Guy J Buckle; Per Höllsberg; David A Hafler
Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.
Neurology 2003;60(4):702-5.
2003: Enedina M L Oliveira; Amit Bar-Or; Alicja I Waliszewska; Guifang Cai; David E Anderson; Jeffrey I Krieger; David A Hafler
CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls.
Journal of autoimmunity 2003;20(1):71-81.
2003: Clare Baecher-Allan; Julia A Brown; Gordon J Freeman; David A Hafler
CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo.
Novartis Foundation symposium 2003;252():67-88; discussion 88-91, 106-14.
2003: Duojia Cao; Vivianne Malmström; Clare Baecher-Allan; David A Hafler; Lars Klareskog; Christina Trollmo
Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis.
European journal of immunology 2003;33(1):215-23.
2003: Orhun H Kantarci; David D Hebrink; Sara J Achenbach; Elizabeth J Atkinson; Alicja Waliszewska; Guy J Buckle; Cynthia T McMurray; Mariza de Andrade; David A Hafler; Brian G Weinshenker
CTLA4 is associated with susceptibility to multiple sclerosis.
Journal of neuroimmunology 2003;134(1-2):133-41.
2002: Clare Baecher-Allan; Vissia Viglietta; David A Hafler
Inhibition of human CD4(+)CD25(+high) regulatory T cell function.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6210-7.
2002: Dong-Gyun Lim; Per Höllsberg; David A Hafler
Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells.
Cellular immunology 2002;217(1-2):36-46.
2002: Vissia Viglietta; Sally C Kent; Tihamer Orban; David A Hafler
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes.
The Journal of clinical investigation 2002;109(7):895-903.
2002: David A Hafler
Degeneracy, as opposed to specificity, in immunotherapy.
The Journal of clinical investigation 2002;109(5):581-4.
2001: Amit Bar-Or; Enedina M L Oliveira; David E Anderson; Jeffrey I Krieger; Martin Duddy; Kevin C O'Connor; David A Hafler
Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5669-77.
2001: K D Bourcier; Dong-Gyun Lim; Y H Ding; K J Smith; Kai W Wucherpfennig; David A Hafler
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure.
Journal of virology 2001;75(20):9836-43.
2001: Clare Baecher-Allan; Julia A Brown; Gordon J Freeman; David A Hafler
CD4+CD25high regulatory cells in human peripheral blood.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1245-53.
2001: Christina Trollmo; Abbie L Meyer; AC Steere; David A Hafler; Brigitte T Huber
Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5286-91.
2001: Kevin C O'Connor; Amit Bar-Or; David A Hafler
The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis.
Journal of clinical immunology 2001;21(2):81-92.
2001: Jacqueline Slavik; Dong-Gyun Lim; Steven J Burakoff; David A Hafler
Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3201-9.
2001: Tihamer Orban; Sally C Kent; P Malik; J D Milner; K Schuster; Rebecca A Jackson; David A Hafler
Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset.
Autoimmunity 2001;34(4):247-64.
2001: David E Anderson; David A Hafler
Immune tolerance and the nervous system.
Advances in experimental medicine and biology 2001;490():79-98.
2001: R Gausling; C Trollmo; David A Hafler
Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis.
Clinical immunology (Orlando, Fla.) 2001;98(1):11-7.
2000: PW Duda; Jeffrey I Krieger; MC Schmied; C Balentine; David A Hafler
Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7300-7.
2000: Dong-Gyun Lim; K Bieganowska Bourcier; Gordon J Freeman; David A Hafler
Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6214-20.
2000: Abbie L Meyer; Christina Trollmo; F Crawford; P Marrack; AC Steere; Brigitte T Huber; J Kappler; David A Hafler
Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11433-8.
2000: B Kipp; Amit Bar-Or; R Gausling; Enedina M L Oliveira; S A Fruhan; W H Stuart; David A Hafler
A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis.
European journal of immunology 2000;30(7):2092-100.
2000: S Brian Wilson; Sally C Kent; Heidi F Horton; A A Hill; Paul L Bollyky; David A Hafler; Jack L Strominger; Michael C Byrne
Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7411-6.
2000: PW Duda; MC Schmied; S L Cook; Jeffrey I Krieger; David A Hafler
Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis.
The Journal of clinical investigation 2000;105(7):967-76.
2000: David E Anderson; K D Bieganowska; Amit Bar-Or; Enedina M L Oliveira; B Carreno; M Collins; David A Hafler
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population.
Nature medicine 2000;6(2):211-4.
1999: Amit Bar-Or; Enedina M L Oliveira; David E Anderson; David A Hafler
Molecular pathogenesis of multiple sclerosis.
Journal of neuroimmunology 1999;100(1-2):252-9.
1999: Sally C Kent; David A Hafler; Jack L Strominger; S Brian Wilson
Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d.
Human immunology 1999;60(11):1080-9.
1999: J D Milner; Sally C Kent; T A Ashley; S Brian Wilson; Jack L Strominger; David A Hafler
Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2522-9.
1999: Jin-Xiong She; Tamir M Ellis; S Brian Wilson; clive wasserfall; MP Marron; S Reimsneider; Sally C Kent; David A Hafler; D S Neuberg; Andrew Muir; Jack L Strominger; Mark A Atkinson
Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8116-9.
1999: G Semana; R Gausling; Rebecca A Jackson; David A Hafler
T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects.
Journal of autoimmunity 1999;12(4):259-67.
1999: A Pohl-Koppe; Eric L Logigian; Allen C Steere; David A Hafler
Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis.
Cellular immunology 1999;194(1):118-23.
1999: D Smith; Guy J Buckle; David A Hafler; D A Frank; Per Höllsberg
HTLV-I-infected T cells evade the antiproliferative action of IFN-beta.
Virology 1999;257(2):314-21.
1999: Lara J Ausubel; KD Bieganowska; David A Hafler
Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein.
Cellular immunology 1999;193(1):99-107.
1999: KD Bieganowska; Per Höllsberg; Guy J Buckle; Dong-Gyun Lim; T F Greten; Jonathan P Schneck; John D Altman; S Jacobson; S L Ledis; Barrie Hanchard; J Chin; Owen Morgan; P A Roth; David A Hafler
Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1765-71.
1998: A Pohl-Koppe; S K Burchett; Elizabeth A Thiele; David A Hafler
Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis.
Journal of neuroimmunology 1998;91(1-2):19-27.
1998: A Windhagen; David E Anderson; A Carrizosa; Konstantin Balashov; Howard L Weiner; David A Hafler
Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis.
Journal of neuroimmunology 1998;91(1-2):1-9.
1998: H Takashima; D R Smith; Hikoaki Fukaura; Samia J Khoury; David A Hafler; Howard L Weiner
Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients.
Clinical immunology and immunopathology 1998;88(1):28-34.
1998: O Mandelboim; S Kent; DM Davis; S Brian Wilson; T Okazaki; R Jackson; David A Hafler; Jack L Strominger
Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3798-803.
1998: A Pohl-Koppe; Konstantin Balashov; Allen C Steere; Eric L Logigian; David A Hafler
Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1804-10.
1998: C Scholz; K T Patton; David E Anderson; Gordon J Freeman; David A Hafler
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1532-8.
1998: S Brian Wilson; Sally C Kent; K T Patton; Tihamer Orban; Rebecca A Jackson; Mark A Exley; Steven A Porcelli; Desmond A Schatz; M A Atkinson; Steven P Balk; Jack L Strominger; David A Hafler
Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.
Nature 1998;391(6663):177-81.
1997: David A Hafler; Sally C Kent; M J Pietrusewicz; Samia J Khoury; Howard L Weiner; Hikoaki Fukaura
Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis.
Annals of the New York Academy of Sciences 1997;835():120-31.
1997: A Dressel; J L Chin; A Sette; R Gausling; Per Höllsberg; David A Hafler
Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4943-51.
1997: Per Höllsberg; C Scholz; David E Anderson; Edward Greenfield; Vijay K Kuchroo; Gordon J Freeman; David A Hafler
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4799-805.
1997: DR Smith; Konstantin Balashov; David A Hafler; Samia J Khoury; Howard L Weiner
Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia.
Annals of neurology 1997;42(3):313-8.
1997: Lara J Ausubel; Jeffrey I Krieger; David A Hafler
Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2502-12.
1997: David E Anderson; Lara J Ausubel; J Krieger; Per Höllsberg; Gordon J Freeman; David A Hafler
Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1669-75.
1997: F Dangond; A Windhagen; C J Groves; David A Hafler
Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity.
Journal of neuroimmunology 1997;76(1-2):132-8.
1997: KD Bieganowska; Lara J Ausubel; Y Modabber; E Slovik; Wells A Messersmith; David A Hafler
Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease.
The Journal of experimental medicine 1997;185(9):1585-94.
1997: Sally C Kent; Hikoaki Fukaura; M J Pietrusewicz; Samia J Khoury; Howard L Weiner; David A Hafler
Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients.
Annals of the New York Academy of Sciences 1997;815():412-22.
1997: Edward Greenfield; E Howard; T Paradis; K Nguyen; F Benazzo; P McLean; Per Höllsberg; G Davis; David A Hafler; A H Sharpe; Gordon J Freeman; Vijay K Kuchroo
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2025-34.
1997: Konstantin Balashov; DR Smith; Samia J Khoury; David A Hafler; Howard L Weiner
Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):599-603.
1996: Lara J Ausubel; C K Kwan; Alessandro Sette; Vijay K Kuchroo; David A Hafler
Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15317-22.
1996: Per Höllsberg; V Batra; A Dressel; David A Hafler
Induction of anergy in CD8 T cells by B cell presentation of antigen.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5269-76.
1996: C Scholz; G J Freeman; Edward Greenfield; David A Hafler; Per Höllsberg
Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):2932-8.
1996: C Scholz; David A Hafler; Per Höllsberg
Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells.
Journal of neuroscience research 1996;45(6):786-94.
1996: Hikoaki Fukaura; Sally C Kent; M J Pietrusewicz; Samia J Khoury; Howard L Weiner; David A Hafler
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.
The Journal of clinical investigation 1996;98(1):70-7.
1996: David A Hafler; M G Saadeh; Vijay K Kuchroo; E Milford; L Steinman
TCR usage in human and experimental demyelinating disease.
Immunology today 1996;17(4):152-9.
1996: M Matsui; David A Hafler; Howard L Weiner
Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency.
Annals of the New York Academy of Sciences 1996;778():398-404.
1996: Hikoaki Fukaura; Sally C Kent; M J Pietrusewicz; Samia J Khoury; Howard L Weiner; David A Hafler
Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis.
Annals of the New York Academy of Sciences 1996;778():251-7.
1996: MJ Hohol; Samia J Khoury; S L Cook; E J Orav; David A Hafler; Howard L Weiner
Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial.
Annals of the New York Academy of Sciences 1996;778():243-50.
1996: A Windhagen; Lindsay B Nicholson; Howard L Weiner; Vijay K Kuchroo; David A Hafler
Role of Th1 and Th2 cells in neurologic disorders.
Chemical immunology 1996;63():171-86.
1996: Guy J Buckle; David A Hafler; Per Höllsberg
HTLV-I-induced T-cell activation.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;13 Suppl 1():S107-13.
1995: A Windhagen; J Newcombe; F Dangond; C Strand; M Nicola Woodroofe; M L Cuzner; David A Hafler
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.
The Journal of experimental medicine 1995;182(6):1985-96.
1995: Silva Markovic-Plese; H Fukaura; J Zhang; A al-Sabbagh; S Southwood; Alessandro Sette; Vijay K Kuchroo; David A Hafler
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):982-92.
1995: Kai W Wucherpfennig; David A Hafler
A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide.
Annals of the New York Academy of Sciences 1995;756():241-58.
1995: Konstantin Balashov; Samia J Khoury; David A Hafler; Howard L Weiner
Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.
The Journal of clinical investigation 1995;95(6):2711-9.
1995: Per Höllsberg; W E Weber; F Dangond; V Batra; Alessandro Sette; David A Hafler
Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):4036-40.
1995: A Windhagen; C Scholz; Per Höllsberg; Hikoaki Fukaura; Alessandro Sette; David A Hafler
Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand.
Immunity 1995;2(4):373-80.
1995: F Dangond; J S Daza; A Rosania; M J Quin; V Zaninovic; B Chaplin; R Marlink; David A Hafler
Tropical spastic paraparesis on the Caribbean coast of Colombia.
The American journal of tropical medicine and hygiene 1995;52(2):155-8.
1995: Howard L Weiner; MJ Hohol; Samia J Khoury; D M Dawson; David A Hafler
Therapy for multiple sclerosis.
Neurologic clinics 1995;13(1):173-96.
1995: David A Hafler; Howard L Weiner
Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease.
Chemical immunology 1995;60():126-49.
1994: Yahua Chen; Vijay K Kuchroo; J Inobe; David A Hafler; Howard L Weiner
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.
Science (New York, N.Y.) 1994;265(5176):1237-40.
1994: Per Höllsberg; Lara J Ausubel; David A Hafler
Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):566-73.
1994: S Zoubak; J H Richardson; A Rynditch; Per Höllsberg; David A Hafler; E Boeri; Andrew M L Lever; G Bernardi
Regional specificity of HTLV-I proviral integration in the human genome.
Gene 1994;143(2):155-63.
1994: Janine M LaSalle; David A Hafler
T cell anergy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(9):601-8.
1994: Kai W Wucherpfennig; J Zhang; C Witek; M Matsui; Y Modabber; K Ota; David A Hafler
Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5581-92.
1994: Vijay K Kuchroo; M Collins; A al-Sabbagh; Raymond A Sobel; M J Whitters; Scott S Zamvil; Martin E Dorf; David A Hafler; Jonathan G Seidman; Howard L Weiner
T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.
The Journal of experimental medicine 1994;179(5):1659-64.
1994: J Zhang; Silva Markovic-Plese; B Lacet; J Raus; Howard L Weiner; David A Hafler
Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.
The Journal of experimental medicine 1994;179(3):973-84.
1994: Howard L Weiner; A Friedman; A Miller; Samia J Khoury; A al-Sabbagh; L Santos; M Sayegh; Robert B Nussenblatt; D E Trentham; David A Hafler
Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens.
Annual review of immunology 1994;12():809-37.
1993: Janine M LaSalle; F Toneguzzo; M Saadeh; D E Golan; R Taber; David A Hafler
T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):649-57.
1993: Per Höllsberg; J Melinek; D Benjamin; David A Hafler
Increased protein kinase C activity in human memory T cells.
Cellular immunology 1993;149(1):170-9.
1993: Howard L Weiner; G A Mackin; E J Orav; David A Hafler; D M Dawson; Y LaPierre; R Herndon; J R Lehrich; Stephen L Hauser; A Turel
Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group.
Neurology 1993;43(5):910-8.
1993: H F Oettinger; A al-Sabbagh; Z Jingwu; Janine M LaSalle; Howard L Weiner; David A Hafler
Biological activity of recombinant human myelin basic protein.
Journal of neuroimmunology 1993;44(2):157-62.
1993: Per Höllsberg; David A Hafler
Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection.
The New England journal of medicine 1993;328(16):1173-82.
1993: David A Hafler; J W Zhang; Janine M LaSalle; C Donnelly; Howard L Weiner; K Wucherpfeffnig
The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis.
Clinical and experimental rheumatology 1993;11 Suppl 8():S39-40.
1993: Howard L Weiner; G A Mackin; M Matsui; E J Orav; Samia J Khoury; D M Dawson; David A Hafler
Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis.
Science (New York, N.Y.) 1993;259(5099):1321-4.
1992: Gordon J Freeman; David Lombard; C D Gimmi; S A Brod; K Lee; J C Laning; David A Hafler; M E Dorf; GS Gray; H Reiser
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):3795-801.
1992: Janine M LaSalle; P J Tolentino; Gordon J Freeman; Lee M Nadler; David A Hafler
Early signaling defects in human T cells anergized by T cell presentation of autoantigen.
The Journal of experimental medicine 1992;176(1):177-86.
1992: Kai W Wucherpfennig; J Newcombe; H Li; C Keddy; M L Cuzner; David A Hafler
Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4588-92.
1992: Per Höllsberg; Kai W Wucherpfennig; Lara J Ausubel; V Calvo; B E Bierer; David A Hafler
Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3256-63.
1992: Kai W Wucherpfennig; J Newcombe; H Li; C Keddy; M L Cuzner; David A Hafler
T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.
The Journal of experimental medicine 1992;175(4):993-1002.
1992: Kai W Wucherpfennig; Per Höllsberg; J H Richardson; D Benjamin; David A Hafler
T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2110-4.
1992: David A Hafler; I Cohen; D S Benjamin; Howard L Weiner
T cell vaccination in multiple sclerosis: a preliminary report.
Clinical immunology and immunopathology 1992;62(3):307-13.
1992: J Zhang; Howard L Weiner; David A Hafler
Autoreactive T cells in multiple sclerosis.
International reviews of immunology 1992;9(3):183-201.
1991: David A Hafler; M Matsui; Kai W Wucherpfennig; K Ota; Howard L Weiner
The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis.
Annals of the New York Academy of Sciences 1991;636():251-65.
1991: Janine M LaSalle; David A Hafler
The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle.
Cellular immunology 1991;138(1):197-206.
1991: S A Brod; D Benjamin; David A Hafler
Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):810-5.
1991: A Miller; David A Hafler; Howard L Weiner
Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(11):2560-6.
1991: Kai W Wucherpfennig; Howard L Weiner; David A Hafler
T-cell recognition of myelin basic protein.
Immunology today 1991;12(8):277-82.
1991: Janine M LaSalle; K Ota; David A Hafler
Presentation of autoantigen by human T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):774-80.
1991: S A Brod; A al-Sabbagh; Raymond A Sobel; David A Hafler; Howard L Weiner
Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig.
Annals of neurology 1991;29(6):615-22.
1991: David A Hafler; John Orav; R Gertz; L Stazzone; Howard L Weiner
Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis.
Journal of neuroimmunology 1991;32(2):149-58.
1991: Sandra Lee; Kai W Wucherpfennig; S A Brod; D Benjamin; Howard L Weiner; David A Hafler
Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.
Annals of neurology 1991;29(1):33-40.
1991: David A Hafler; M Chofflon; E Kurt-Jones; Howard L Weiner
Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis.
Clinical immunology and immunopathology 1991;58(1):115-25.
1990: S A Brod; M Purvee; D Benjamin; David A Hafler
T-T cell interactions are mediated by adhesion molecules.
European journal of immunology 1990;20(10):2259-68.
1990: K Ota; M Matsui; E L Milford; G A Mackin; Howard L Weiner; David A Hafler
T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis.
Nature 1990;346(6280):183-7.
1990: Kai W Wucherpfennig; K Ota; N Endo; Jonathan G Seidman; A Rosenzweig; Howard L Weiner; David A Hafler
Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein.
Science (New York, N.Y.) 1990;248(4958):1016-9.
1990: S A Brod; M Purvee; D Benjamin; David A Hafler
Frequency analysis of CD4+CD8+ T cells cloned with IL-4.
Cellular immunology 1990;125(2):426-36.
1990: N H Dang; David A Hafler; Stuart F Schlossman; J B Breitmeyer
FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation.
Cellular immunology 1990;125(1):42-57.
1989: S A Brod; C E Rudd; M Purvee; David A Hafler
Lymphokine regulation of CD45R expression on human T cell clones.
The Journal of experimental medicine 1989;170(6):2147-52.
1989: M Chofflon; V González; Howard L Weiner; David A Hafler
Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells.
European journal of immunology 1989;19(10):1791-5.
1989: M Chofflon; Howard L Weiner; C Morimoto; David A Hafler
Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid.
Annals of neurology 1989;25(5):494-9.
1989: David A Hafler; M Chofflon; D Benjamin; N H Dang; J Breitmeyer
Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2590-6.
1989: A D Duby; Howard L Weiner; D S Benjamin; Jonathan G Seidman; David A Hafler
Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis.
Journal of neuroimmunology 1989;22(1):63-8.
1989: David A Hafler; S A Brod; Howard L Weiner
Immunoregulation in multiple sclerosis.
Research in immunology 1989;140(2):233-9; discussion 245-8.
1988: M Chofflon; Howard L Weiner; C Morimoto; David A Hafler
Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis.
Annals of neurology 1988;24(2):185-91.
1988: David A Hafler; Howard L Weiner
Immunosuppression with monoclonal antibodies in multiple sclerosis.
Neurology 1988;38(7 Suppl 2):42-7.
1988: J L Carter; David A Hafler; D M Dawson; John Orav; Howard L Weiner
Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.
Neurology 1988;38(7 Suppl 2):9-14.
1988: David A Hafler; Jerome Ritz; S F Schlossman; Howard L Weiner
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):131-8.
1988: David A Hafler; A D Duby; Sandra Lee; D Benjamin; Jonathan G Seidman; Howard L Weiner
Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.
The Journal of experimental medicine 1988;167(4):1313-22.
1988: Howard L Weiner; David A Hafler
Immunotherapy of multiple sclerosis.
Annals of neurology 1988;23(3):211-22.
1988: M L Blue; David A Hafler; J F Daley; H Levine; K A Craig; J B Breitmeyer; Stuart F Schlossman
Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):376-83.
1988: David A Hafler; Howard L Weiner
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses.
Annals of the New York Academy of Sciences 1988;540():557-9.
1988: M Chofflon; Howard L Weiner; David A Hafler
Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis.
Annals of the New York Academy of Sciences 1988;540():330-2.
1988: J L Carter; D M Dawson; David A Hafler; R J Fallis; L Stazzone; John Orav; Howard L Weiner
Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis.
Annals of the New York Academy of Sciences 1988;540():535-6.
1987: M L Blue; David A Hafler; K A Craig; H Levine; Stuart F Schlossman
Phosphorylation of CD4 and CD8 molecules following T cell triggering.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(12):3949-54.
1986: David A Hafler; R J Fallis; D M Dawson; S F Schlossman; Ellis L Reinherz; Howard L Weiner
Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.
Neurology 1986;36(6):777-84.
1984: Howard L Weiner; David A Hafler; R J Fallis; D Johnson; K A Ault; Stephen L Hauser
Altered blood T-cell subsets in patients with multiple sclerosis.
Journal of neuroimmunology 1984;6(2):115-21.
1984: Howard L Weiner; David A Hafler; R J Fallis; D Johnson; K A Ault; Stephen L Hauser
T cell subsets in patients with multiple sclerosis. An overview.
Annals of the New York Academy of Sciences 1984;436():281-93.
1984: Howard L Weiner; Stephen L Hauser; David A Hafler; R J Fallis; J R Lehrich; D M Dawson
The use of cyclophosphamide in the treatment of multiple sclerosis.
Annals of the New York Academy of Sciences 1984;436():373-81.